Search our Database of Scientific Publications and Authors

I’m looking for a

    4090 results match your criteria Adrenal Disease and Pregnancy

    1 OF 82

    Newborn genome-wide DNA methylation in association with pregnancy anxiety reveals a potential role for GABBR1.
    Clin Epigenetics 2017 3;9:107. Epub 2017 Oct 3.
    Department of Neurosciences, Genetic Research About Stress and Psychiatry (GRASP), KU Leuven, Leuven, Belgium.
    Background: There is increasing evidence for the role of prenatal stress in shaping offspring DNA methylation and disease susceptibility. In the current study, we aimed to identify genes and pathways associated with pregnancy anxiety using a genome-wide DNA methylation approach.

    Methods: We selected 22 versus 23 newborns from our Prenatal Early Life Stress (PELS) cohort, exposed to the lowest or highest degree of maternal pregnancy anxiety, respectively. Read More

    The highs and lows of programmed cardiovascular disease by developmental hypoxia: studies in the chicken embryo.
    J Physiol 2017 Oct 5. Epub 2017 Oct 5.
    Department of Physiology, Development & Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK.
    It is now established that adverse conditions during pregnancy can trigger a fetal origin of cardiovascular dysfunction and/or increase the risk of heart disease in later life. Sub-optimal environmental conditions during early life that may promote the development of cardiovascular dysfunction in the offspring include alterations in fetal oxygenation and nutrition as well as fetal exposure to stress hormones, such as glucocorticoids. There has been growing interest in identifying the partial contributions of each of these stressors to programming of cardiovascular dysfunction. Read More

    Sensitive Monogenic Noninvasive Prenatal Diagnosis by Targeted Haplotyping.
    Am J Hum Genet 2017 Sep 24;101(3):326-339. Epub 2017 Aug 24.
    Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands. Electronic address:
    During pregnancy, cell-free DNA (cfDNA) in maternal blood encompasses a small percentage of cell-free fetal DNA (cffDNA), an easily accessible source for determination of fetal disease status in risk families through non-invasive procedures. In case of monogenic heritable disease, background maternal cfDNA prohibits direct observation of the maternally inherited allele. Non-invasive prenatal diagnostics (NIPD) of monogenic diseases therefore relies on parental haplotyping and statistical assessment of inherited alleles from cffDNA, techniques currently unavailable for routine clinical practice. Read More

    Adrenal Cushing's syndrome during pregnancy.
    Eur J Endocrinol 2017 Nov 17;177(5):K13-K20. Epub 2017 Aug 17.
    Department of Internal MedicineErasmus Medical Center, Rotterdam, The Netherlands.
    Cushing syndrome (CS) during pregnancy is a rare condition with only a few cases reported in the literature. Misdiagnosis of CS is common because of overlapping features like fatigue, weight gain, striae and emotional changes that can occur during normal pregnancy. Changes in maternal hormones and their binding proteins complicate assessment of glucocorticoid hormone levels during gestation. Read More

    Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy.
    Neurosci Biobehav Rev 2017 Jul 28. Epub 2017 Jul 28.
    Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany. Electronic address:
    Accumulating research shows that prenatal exposure to maternal stress increases the risk for behavioral and mental health problems later in life. This review systematically analyzes the available human studies to identify harmful stressors, vulnerable periods during pregnancy, specificities in the outcome and biological correlates of the relation between maternal stress and offspring outcome. Effects of maternal stress on offspring neurodevelopment, cognitive development, negative affectivity, difficult temperament and psychiatric disorders are shown in numerous epidemiological and case-control studies. Read More

    The use of a unique co-culture model of fetoplacental steroidogenesis as a screening tool for endocrine disruptors: The effects of neonicotinoids on aromatase activity and hormone production.
    Toxicol Appl Pharmacol 2017 Oct 24;332:15-24. Epub 2017 Jul 24.
    INRS - Institut Armand-Frappier, Laval, QC H7V 1B7, Canada. Electronic address:
    Estrogen biosynthesis during pregnancy is dependent on the collaboration between the fetus producing the androgen precursors, and the placenta expressing the enzyme aromatase (CYP19). Disruption of estrogen production by contaminants may result in serious pregnancy outcomes. We used our recently developed in vitro co-culture model of fetoplacental steroidogenesis to screen the effects of three neonicotinoid insecticides on the catalytic activity of aromatase and the production of steroid hormones. Read More

    Corticotropin-Releasing Hormone As the Homeostatic Rheostat of Feto-Maternal Symbiosis and Developmental Programming In Utero and Neonatal Life.
    Front Endocrinol (Lausanne) 2017 11;8:161. Epub 2017 Jul 11.
    Translational Medicine, Warwick Medical School, Coventry, United Kingdom.
    A balanced interaction between the homeostatic mechanisms of mother and the developing organism during pregnancy and in early neonatal life is essential in order to ensure optimal fetal development, ability to respond to various external and internal challenges, protection from adverse programming, and safeguard maternal care availability after parturition. In the majority of pregnancies, this relationship is highly effective resulting in successful outcomes. However, in a number of pathological settings, perturbations of the maternal homeostasis disrupt this symbiosis and initiate adaptive responses with unpredictable outcomes for the fetus or even the neonate. Read More

    Exposure to intimate partner violence in utero and infant internalizing behaviors: Moderation by salivary cortisol-alpha amylase asymmetry.
    Early Hum Dev 2017 Jul 20;113:40-48. Epub 2017 Jul 20.
    Department of Psychology, Michigan State University, USA.
    Guided by the main tenets of contemporary models of the developmental origins of health and disease, this study evaluated whether individual differences in reactivity of the hypothalamic-pituitary-adrenal (HPA) axis and Sympathetic Nervous System (SNS) moderate the effect of prenatal exposure to trauma on internalizing and externalizing behaviors during infancy. Participants were a community sample of 182 mothers (M age=25years, 43% Caucasian, 33% Black/African American, 24% Biracial/Other) and their infants (59% girls; M age=11.8months). Read More

    Fetal and neonatal alloimmune thrombocytopenia: evidence based antenatal and postnatal management strategies.
    Expert Rev Hematol 2017 Aug 29;10(8):729-737. Epub 2017 Jun 29.
    c Division of Neonatology, Department of Pediatrics , Leiden University Medical Center , Leiden , The Netherlands.
    Introduction: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a relatively rare but potentially lethal disease, leading to severe bleeding complications in 1 in 11.000 newborns. It is the leading cause of thrombocytopenia in healthy term-born neonates. Read More

    Non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency revisited: an update with a special focus on adolescent and adult women.
    Hum Reprod Update 2017 Sep;23(5):580-599
    Departments of Obstetrics/Gynecology, and Medicine, Augusta University, Augusta, GA, USA.
    Background: Non-classic congenital hyperplasia (NCAH) due to 21-hydroxylase deficiency is a common autosomal recessive disorder characterized by androgen excess.

    Objective And Rationale: We conducted a systematic review and critical assessment of the available evidence pertaining to the epidemiology, pathophysiology, diagnosis and management of NCAH. A meta-analysis of epidemiological data was also performed. Read More

    Mechanisms of Glucocorticoid Action During Development.
    Curr Top Dev Biol 2017 16;125:147-170. Epub 2017 Jan 16.
    Molecular Endocrinology Group, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, United States. Electronic address:
    Glucocorticoids are primary stress hormones produced by the adrenal cortex. The concentration of serum glucocorticoids in the fetus is low throughout most of gestation but surge in the weeks prior to birth. While their most well-known function is to stimulate differentiation and functional development of the lungs, glucocorticoids also play crucial roles in the development of several other organ systems. Read More

    Anxiety and Epigenetics.
    Adv Exp Med Biol 2017 ;978:145-166
    Department of Psychology, University of Massachusetts, 100 Morrissey Blvd, Boston, MA, 02125, USA.
    Anxiety disorders are highly prevalent psychiatric disorders often comorbid with depression and substance abuse. Twin studies have shown that anxiety disorders are moderately heritable. Yet, genome-wide association studies (GWASs) have failed to identify gene(s) significantly associated with diagnosis suggesting a strong role for environmental factors and the epigenome. Read More

    Neurobehavioral risks of SSRIs in pregnancy: Comparing human and animal data.
    Reprod Toxicol 2017 Sep 8;72:191-200. Epub 2017 May 8.
    Laboratory of Teratology, Department of Medical Neurobiology, Hebrew University Hadassah Medical School, Jerusalem, Israel. Electronic address:
    During the last twenty years, in spite of extensive literature regarding the use of SSRIs in pregnancy, confusion still exists as to possible long-term risks of these drugs on the offspring. Possible negative effects relate to neurodevelopmental outcome and association with Autism Spectrum Disorder (ASD). Most neurodevelopmental follow up studies did not find significant cognitive impairment except from some apparently transient, gross motor delay and slight impairment of language abilities. Read More

    Antenatal corticosteroids for neonates born before 25 Weeks-A systematic review and meta-analysis.
    PLoS One 2017 9;12(5):e0176090. Epub 2017 May 9.
    Department of Neonatal Pediatrics, King Edward Memorial Hospital, Perth, Western Australia.
    Background: Efficacy of antenatal corticosteroids before 25 weeks of gestation is unclear.

    Objective: To assess and compare neonatal outcomes following ANC exposure at 22, 23 and 24 weeks of gestation by conducting systematic review and meta- analysis.

    Methods: A systematic review of randomised controlled trials (RCT) and non-RCTs reporting on neonatal outcomes after exposure to ANC up to 246 weeks of gestation using the Cochrane systematic review methodology. Read More

    Management of a multiple endocrine neoplasia type 1 during pregnancy: A case report and review of the literature.
    J Exp Ther Oncol 2016 Jul;11(3):217-220
    Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
    Multiple Endocrine Neoplasia Type 1 (MEN1) or Wermer's syndrome is a rare hereditary endocrine syndrome with high penetrance caused by mutations in MEN1 tumor suppressor gene. MEN1 is characterized by hyperplasia or tumoral enlargement in a number of endocrine organs (parathyroid glands, pancreas, pituitary gland, adrenal gland) and it could be hormonally active or inactive. MEN1 is a significant cause of morbidity due to hormone secretion and mass effect. Read More

    Pregnancy outcomes in women with different doses of corticosteroid supplementation during labor and delivery.
    J Obstet Gynaecol Res 2017 Jul 19;43(7):1132-1138. Epub 2017 Apr 19.
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.
    Aim: The aim of this study was to report the pregnancy outcomes of women who received different doses of corticosteroid supplementation during labor and delivery.

    Methods: We conducted a retrospective review of 102 pregnant women who received oral corticosteroid therapy, delivered at Osaka University Hospital, and were administered intravenous corticosteroid supplementation during labor and delivery. From January 2008 to May 2012, 47 women were administered a high dose of corticosteroids (HD group). Read More

    ENDOCRINOLOGY IN PREGNANCY: Pheochromocytoma in pregnancy: case series and review of literature.
    Eur J Endocrinol 2017 Aug 5;177(2):R49-R58. Epub 2017 Apr 5.
    Department of Internal MedicineErasmus MC, University Medical Center, Rotterdam, The Netherlands
    Pheochromocytoma in pregnancy is extremely rare. Early recognition is crucial as antepartum diagnosis can largely decrease maternal and fetal mortality rates. As symptoms of pheochromocytoma are rather similar to those of other far more common causes of hypertension during pregnancy, timely diagnosis is a challenge. Read More

    Prenatal diagnosis of Bartter syndrome: amniotic fluid aldosterone.
    Ann Biol Clin (Paris) 2017 Apr;75(2):204-208
    Service de biochimie-hormonologie, Hôpital Robert Debré, AP-HP, Paris, France, Service de biochimie, Université Versailles Saint-Quentin-en-Yvelines, France.
    Bartter syndrome is a severe inherited tubulopathy characterized at birth by salt wasting, severe polyuria, dehydration, growth retardation and secondary hyperaldosteronism. Prenatally, the disease is usually discovered following onset of severe polyhydramnios. We studied amniotic fluid aldosterone concentration in cases of Bartter syndrome and in control groups. Read More

    Life-threatening endocrine emergencies during pregnancy - management and therapeutic features.
    Gynecol Endocrinol 2017 Jul 31;33(7):510-514. Epub 2017 Mar 31.
    b Department of Medicine II , University of Lübeck , Lübeck , Germany.
    Endocrine emergencies during pregnancy may be life-threatening events for both mother and fetus. Besides pregnancy-associated endocrine disorders, several pre-existing endocrinopathies such as type-1 diabetes and Grave's disease or adrenal failure may acutely deteriorate during pregnancy. Since "classical" signs are often modified by pregnancy, early diagnosis and management may be hampered. Read More

    Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.
    Cochrane Database Syst Rev 2017 03 21;3:CD004454. Epub 2017 Mar 21.
    Liggins Institute, The University of Auckland, Park Rd, Grafton, Auckland, New Zealand, 1142.
    Background: Respiratory morbidity including respiratory distress syndrome (RDS) is a serious complication of preterm birth and the primary cause of early neonatal mortality and disability. While researching the effects of the steroid dexamethasone on premature parturition in fetal sheep in 1969, Liggins found that there was some inflation of the lungs of lambs born at gestations at which the lungs would be expected to be airless. Liggins and Howie published the first randomised controlled trial in humans in 1972 and many others followed. Read More

    A successful case of pregnancy in a woman with ACTH-independent Cushing's syndrome treated with ketoconazole and metyrapone.
    Gynecol Endocrinol 2017 May 26;33(5):349-352. Epub 2017 Feb 26.
    b Department of Clinical Endocrinology and Metabolic Disease , Polish Mother's Memorial Hospital Research Institute , Lodz , Poland.
    Cushing's syndrome (CS) is a rare disease caused by a chronic excess of cortisol. Hypercortisolaemia may affect reproductive system leading to infertility in women. However, some of the patients remain fertile, although pregnancy is uncommon. Read More

    Transfer of maternal psychosocial stress to the fetus.
    Neurosci Biobehav Rev 2017 Feb 22. Epub 2017 Feb 22.
    Hans Berger Department of Neurology, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany. Electronic address:
    Psychosocial maternal stress experienced during different vulnerable periods throughout gestation is thought to increase the individual's risk to develop neuropsychiatric, cardiovascular and metabolic disease in later life. Cortisol has generally been identified as the major mediator of maternal stress transfer to the fetus. Its lipophilic nature allows a trans-placental passage and thus excessive maternal cortisol could persistently impair the development of the fetal hypothalamic-pituitary-adrenal axis (HPAA). Read More

    Sex-Specific Neurodevelopmental Programming by Placental Insulin Receptors on Stress Reactivity and Sensorimotor Gating.
    Biol Psychiatry 2017 Jul 30;82(2):127-138. Epub 2016 Dec 30.
    Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
    Background: Diabetes, obesity, and overweight are prevalent pregnancy complications that predispose offspring to neurodevelopmental disorders, including autism, attention-deficit/hyperactivity disorder, and schizophrenia. Although male individuals are three to four times more likely than female individuals to develop these disorders, the mechanisms driving the sex specificity of disease vulnerability remain unclear. Because defective placental insulin receptor (InsR) signaling is a hallmark of pregnancy metabolic dysfunction, we hypothesized that it may be an important contributor and novel mechanistic link to sex-specific neurodevelopmental changes underlying disease risk. Read More

    Safety of treatments for inflammatory bowel disease: Clinical practice guidelines of the Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD).
    Dig Liver Dis 2017 04 17;49(4):338-358. Epub 2017 Jan 17.
    San Giuseppe Hospital, Gastroenterology, Milan, Italy.
    Inflammatory bowel diseases are chronic conditions of unknown etiology, showing a growing incidence and prevalence in several countries, including Italy. Although the etiology of Crohn's disease and ulcerative colitis is unknown, due to the current knowledge regarding their pathogenesis, effective treatment strategies have been developed. Several guidelines are available regarding the efficacy and safety of available drug treatments for inflammatory bowel diseases. Read More

    [Tetraparesis revealing Conn adenoma in a pregnant woman].
    Pan Afr Med J 2016 27;25:24. Epub 2016 Sep 27.
    Service de Médecine Interne, Hôpital Militaire d'Instruction Mohammed V, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.
    We report the case of Conn adenoma revealed by tetraparesis in a 33-year old pregnant woman at the 16(th)week of amenorrhea. The patient had a blood pressure of 147/87 mmHg, which was considered high-normal, hypokalemia at 1.1 mmol/l. Read More

    Case Report: Acute Flair of Ulcerative Colitis during Pregnancy Is Still a Major Problem.
    Dig Dis 2017 1;35(1-2):134-138. Epub 2017 Feb 1.
    Department of Gastroenterology, University Hospital Zvezdara, Belgrade, Serbia.
    Although severe flare of ulcerative colitis (UC) is uncommon, it significantly increases the risk of preterm delivery, low birth weight and other adverse fetal outcomes. It is critical to optimize aggressive medical treatment with both mother and fetal health. Here, we present a case of a 30-year-old woman with a severe flare of UC at the 16th gestational week. Read More

    Bell's facial nerve palsy in pregnancy: a clinical review.
    J Obstet Gynaecol 2017 May 31;37(4):409-415. Epub 2017 Jan 31.
    a Corneoplastic Unit , Queen Victoria Hospital NHS Foundation Trust , East Grinstead , UK.
    Bell's facial nerve palsy (FNP) during pregnancy and the puerperium can present significant challenges for the patient and clinician. Presentation and prognosis can be worse in this group of patients. This article reviews the background, manifestation and management options of FNP. Read More

    Combined Effects of Gestational Phthalate Exposure and Zinc Deficiency on Steroid Metabolism and Growth.
    Toxicol Sci 2017 Apr;156(2):469-479
    Departments of Nutrition and of Environmental Toxicology, University of California, Davis, California 95616.
    Disruption of steroid hormone signaling has been implicated independently in the developmental abnormalities resulting from maternal phthalate plasticizer exposure and developmental zinc deficiency. This study investigated if secondary zinc deficiency may result from dietary exposure to a low level of di-2-ethylhexyl phthalate (DEHP) through gestation and if this could be associated with altered steroid metabolism. The interaction between marginal zinc nutrition and DEHP exposure to affect pregnancy outcome, zinc status, and steroid metabolism was also assessed. Read More

    Neonatal neuroblastoma with adrenal primary and metastasis to the liver: A case report and a review of literature.
    Afr J Paediatr Surg 2016 Oct-Dec;13(4):217-222
    Department of Radiodiagnosis, Lagos University Teaching Hospital, Lagos, Nigeria.
    We report the case of a 23-day-old neonate with neuroblastoma (NBL) in the right adrenal gland and widespread metastases to the liver. This raises the possibility of foetal NBL, which was missed during periodic ultrasonography done during the mother's pregnancy. We hope that this report would increase the awareness of physicians about foetal, congenital and neonatal NBL; and of sonographers about space-occupying lesions in the foetus. Read More

    Hypertension: The role of biochemistry in the diagnosis and management.
    Clin Chim Acta 2017 Feb 19;465:131-143. Epub 2016 Dec 19.
    Dept. of Clinical Biochemistry & Diagnostic Endocrinology, Mater Misericordiae University Hospital, Dublin, Ireland.
    Hypertension is defined as a persistently elevated blood pressure ≥140/90mmHg. It is an important treatable risk factor for cardiovascular disease, with a high prevalence in the general population. The most common cause, essential hypertension, is a widespread disease - however, secondary hypertension is under investigated and under diagnosed. Read More

    Former Very Preterm Infants Show an Unfavorable Cardiovascular Risk Profile at a Preschool Age.
    PLoS One 2016 13;11(12):e0168162. Epub 2016 Dec 13.
    Department of Pediatrics, Pediatrics II (Neonatology), Medical University of Innsbruck, Innsbruck, Austria.
    Cardiovascular disease is the leading cause of death worldwide. Evidence points towards an unfavorable cardiovascular risk profile of former preterm infants in adolescence and adulthood. The aim of this study was to determine whether cardiovascular risk predictors are detectable in former very preterm infants at a preschool age. Read More

    Mortality in patients with diabetes mellitus and Addison's disease: a nationwide, matched, observational cohort study.
    Eur J Endocrinol 2017 Jan;176(1):31-39
    Department of Internal Medicine and Clinical NutritionInstitute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Objective: Our hypothesis was that patients with diabetes mellitus obtain an additional risk of death if they develop Addison's disease (AD).

    Design And Methods: Nationwide, matched, observational cohort study cross-referencing the Swedish National Diabetes Register with Inpatient, Cancer and Cause of Death Registers in patients with diabetes (type 1 and 2) and AD and matched controls with diabetes. Clinical characteristics at baseline, overall, and cause-specific mortality were assessed. Read More

    Adrenalectomy for Cushing's syndrome: do's and don'ts.
    J Med Life 2016 Oct-Dec;9(4):334-341
    "I. Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Endocrinology, Clinical County Hospital, Cluj-Napoca, Romania.
    Aim. To present specific aspects of adrenalectomy for Cushing's syndrome (CS) by introducing well established aspects ("do's") and less known aspects ("don'ts"). Material and Method. Read More

    Thirty-Eight-Year Follow-Up of Two Sibling Lipoid Congenital Adrenal Hyperplasia Patients Due to Homozygous Steroidogenic Acute Regulatory (STARD1) Protein Mutation. Molecular Structure and Modeling of the STARD1 L275P Mutation.
    Front Neurosci 2016 21;10:527. Epub 2016 Nov 21.
    Department of Biochemistry, Faculty of Medicine, University of Sherbrooke Sherbrooke, QC, Canada.
    Objective: Review the impact of StAR (STARD1) mutations on steroidogenesis and fertility in LCAH patients. Examine the endocrine mechanisms underlying the pathology of the disorder and the appropriate therapy for promoting fertility and pregnancies. Design: Published data in the literature and a detailed 38-year follow-up of two sibling LCAH patients. Read More

    Pheochromocytoma in neurofibromatosis type 1 during pregnancy.
    Gynecol Endocrinol 2017 Feb 2;33(2):93-95. Epub 2016 Dec 2.
    a Department of Endocrinology and Nutrition , Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla , Seville , Spain.
    Pregnant women with neurofibromatosis type 1 (NF-1) have increased complications during gestation, including hypertensive disorders that are sometimes caused by pheochromocytoma. Pheochromocytoma is an extremely rare condition during pregnancy, and the main clinical manifestation is hypertension. If not properly treated, pheochromocytoma has high maternal and fetal mortality rates. Read More

    Maternal epigenetics and fetal and neonatal growth.
    Curr Opin Endocrinol Diabetes Obes 2017 Feb;24(1):43-46
    Department of Medical Genetics, Medical School, National and Kapodistrian University of Athens, Greece.
    Purpose Of Review: The article provides an update on new insights of factors altering inherited maternal epigenome that ultimately affect fetal and neonatal growth.

    Recent Findings: A number of new publications have identified mechanisms through which maternal nutrition, environmental exposures such as stress and toxic substances altering expression of imprinted genes during pregnancy can influence fetal and neonatal phenotype and susceptibility to disease development later in life. The possible causes of metabolic syndrome by in-utero epigenetic alterations of genes involved in energy metabolism (PPARγ and PPARα), microRNAs, arginine methyltransferases, lysine demethylases, and histone deacetylaces have been elucidated. Read More

    [Adrenocortical oncocytoma presenting as Cushing´s syndrome in pregnancy with spontaneous postpartum uterine rupture].
    Ceska Gynekol 2016 ;81(3):228-232
    Objective: The description of rare case of the Cushings syndrome in pregnancy resulting in the spontaneous rupture of uterus.

    Designs: A case report.

    Setting: Department of Gynecology and Obstetrics, 1st Medical Faculty of Charles University and Hospital Na Bulovce. Read More

    Fetal Exposure to Low Levels of the Plasticizer DEHP Predisposes the Adult Male Adrenal Gland to Endocrine Disruption.
    Endocrinology 2017 02;158(2):304-318
    Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada
    In utero exposure to endocrine disrupting chemicals (EDCs) may affect adult health. Di-(2-ethylhexyl) phthalate (DEHP) is an EDC widely used in the production of polyvinyl chloride products and an ubiquitous environmental contaminant. We used a rat model system to show that fetal exposure to DEHP decreased levels of major steroid hormones in adulthood and that environmentally-relevant levels of DEHP affected both gene expression and epigenomic loci that were affected by exposure to high levels. Read More

    Surfactant Protein A and B Gene Polymorphisms and Risk of Respiratory Distress Syndrome in Late-Preterm Neonates.
    PLoS One 2016 11;11(11):e0166516. Epub 2016 Nov 11.
    Neonatal Intensive Care Unit, Department of Pediatrics, Faculty of Medicine, University of Patras, Rio, Patras, Greece.
    Background And Objectives: Newborns delivered late-preterm (between 340/7 and 366/7 weeks of gestation) are at increased risk of respiratory distress syndrome (RDS). Polymorphisms within the surfactant protein (SP) A and B gene have been shown to predispose to RDS in preterm neonates. The aim of this study was to investigate whether specific SP-A and/or SP-B genetic variants are also associated with RDS in infants born late-preterm. Read More

    A successfully treated case of cardiac arrest after Caesarean section complicated by pheochromocytoma crisis and amniotic fluid embolism.
    J Anesth 2017 Feb 10;31(1):140-143. Epub 2016 Nov 10.
    Department of Intensive Care Unit, University of Fukui Hospital, 23-3 Matsuoka Shimoaizuki, Eiheijicho, Yoshidagun, Fukui, 910-1193, Japan.
    Both pheochromocytoma and amniotic fluid embolism (AFE) are important causes of maternal mortality. We present a case of a 29-year-old woman who developed cardiac arrest after Caesarean section, complicated by both pheochromocytoma crisis and AFE. After resuscitation, the patient developed multiple organ dysfunction, rhabdomyolysis and disseminated intravascular coagulation (DIC). Read More

    A design thinking approach to primary ovarian insufficiency.
    Panminerva Med 2017 Mar 9;59(1):15-32. Epub 2016 Nov 9.
    Division of Intramural Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA -
    Most clinicians are not prepared to provide integrated personal care to address all the clinical needs of women with primary ovarian insufficiency. Design thinking is an engineering methodology used to develop and evaluate novel concepts for systems operation. Here we articulate the need for a seamlessly integrated mobile health system to support genomic research as well as patient care. Read More

    Preconception management of endocrine disorders.
    J Pak Med Assoc 2016 Nov;66(11):1494-1496
    Department of Endocrinology, Bharti Hospital, Karnal, All India Institute of Medical Sciences, New Delhi, India.
    Endocrine function is closely interlinked with pregnancy. Maternal and foetal outcomes can be improved if optimal endocrine function is achieved, and maintained prior to conception. This needs a systematic approach which includes rational screening, appropriate management, and pragmatic counseling. Read More

    Recurrence of phaeochromocytoma in pregnancy in a patient with multiple endocrine neoplasia 2A: a case report and review of literature.
    Gynecol Endocrinol 2016 Nov 3;32(11):875-880. Epub 2016 Nov 3.
    d Consultant in Obstetrics and Gynaecology, Wrexham Maelor Hospital , Wales , UK.
    Multiple endocrine neoplasia type 2A (MEN 2A) is an autosomal dominant inherited condition with a prevalence of one in 40 000 individuals. It causes the development of tumours in endocrine glands, such as medullary thyroid cancer, pheochromocytomas, as well as primary hyperparathyroidism. MEN 2A in pregnancy is very rare with only 29 cases reported in the literature. Read More

    Long-term metabolic risk among children born premature or small for gestational age.
    Nat Rev Endocrinol 2017 Jan 19;13(1):50-62. Epub 2016 Aug 19.
    Dutch Growth Research Foundation, 3001 KB Rotterdam, The Netherlands.
    Accumulating evidence suggests that both the intrauterine environment and growth during early life can influence the development of chronic noncommunicable diseases, such as type 2 diabetes mellitus and cardiovascular disease, in adulthood. Here, we review the available human data supporting increased metabolic risk among children born premature or small for gestational age; the adrenal and pubertal modifications that contribute to this risk; metabolic changes that occur during adolescence and early adulthood; and approaches to potentially modify or decrease risk of metabolic disease. The risks associated with delivery at term or preterm are compared for each period of life. Read More

    Prenatal maternal depression is associated with offspring inflammation at 25 years: a prospective longitudinal cohort study.
    Transl Psychiatry 2016 Nov 1;6(11):e936. Epub 2016 Nov 1.
    Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
    Animal studies and a handful of prospective human studies have demonstrated that young offspring exposed to maternal prenatal stress show abnormalities in immune parameters and hypothalamic-pituitary-adrenal (HPA) axis function. No study has examined the effect of maternal prenatal depression on offspring inflammation and HPA axis activity in adulthood, nor the putative role of child maltreatment in inducing these abnormalities. High-sensitivity C-reactive protein (hs-CRP) and awakening cortisol were measured at age 25 in 103 young-adult offspring of the South London Child Development Study (SLCDS), a prospective longitudinal birth cohort of mother-offspring dyads recruited in pregnancy in 1986. Read More

    Sex-Specific Metabolic Outcomes in Offspring of Female Rats Born Small or Exposed to Stress During Pregnancy.
    Endocrinology 2016 Nov 29;157(11):4104-4120. Epub 2016 Aug 29.
    Department of Physiology (J.N.C., A.J.J., K.A., M.E.W.), Faculty of Medicine, Dentistry and Health Sciences, School of Biomedical Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia; School of Biomedical Sciences (J..S.M.C., K.M.M.), University of Queensland, St. Lucia, Queensland 4072, Australia; School of Medical Science (J.S.M.C.), Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia; and Department of Physiology (K.A.), Anatomy and Microbiology, La Trobe University, Bundoora, Victoria, 3086, Australia.
    Low birth weight increases adult metabolic disease risk in both the first (F1) and second (F2) generation. Physiological stress during pregnancy in F1 females that were born small induces F2 fetal growth restriction, but the long-term metabolic health of these F2 offspring is unknown. Uteroplacental insufficiency (restricted) or sham (control) surgery was performed in F0 rats. Read More

    Extracorporeal Membrane Oxygenation for Treatment of Acute Inverted Takotsubo-Like Cardiomyopathy From Hemorrhagic Pheochromocytoma in Late Pregnancy.
    A A Case Rep 2016 Nov;7(9):196-199
    From the *Institute for Anesthesiology & Intensive Care Medicine, Triemli Hospital, Zürich, Switzerland; and †Clinic for Cardiac Surgery, Triemli Hospital, Zürich, Switzerland.
    We describe the first case of a pregnant woman presenting with an acute inverted takotsubo-like cardiomyopathy caused by a postpartum diagnosed hemorrhagic pheochromocytoma, successfully treated with percutaneous venoarterial extracorporeal membrane oxygenation (va-ECMO). During admission, an emergency cesarean delivery had to be performed. The fetus needed resuscitation for 5 minutes. Read More

    Postpartum hypothalamic adrenal insufficiency with remission: A rare case.
    Endocr J 2017 Feb 25;64(2):157-162. Epub 2016 Oct 25.
    Department of Endocrinology and Diabetes Mellitus, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
    A 37-year-old female patient was hospitalized because of general fatigue and loss of axillary and pubic hair after massive bleeding at delivery of her third child. The basal levels of both plasma adrenocorticotropin hormone (ACTH) and serum cortisol were very low, 5.2 pg/mL and 1. Read More

    Preadolescent Adversity Programs a Disrupted Maternal Stress Reactivity in Humans and Mice.
    Biol Psychiatry 2017 Apr 26;81(8):693-701. Epub 2016 Aug 26.
    Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Penn PROMOTES Research on Sex and Gender in Health, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
    Background: Adverse childhood experiences (ACEs) are one of the greatest predictors of affective disorders for women. Periods of dynamic hormonal flux, including pregnancy, exacerbate the risk for affective disturbance and promote hypothalamic-pituitary-adrenal (HPA) axis dysregulation, a key feature of affective disorders. Little is understood as to how stress experienced in late childhood, defined as preadolescence, alters the programming unique to this period of brain maturation and its interaction with the hormonal changes of pregnancy and postpartum. Read More

    1 OF 82