Search our Database of Scientific Publications and Authors

I’m looking for a

    4068 results match your criteria Adrenal Disease and Pregnancy

    1 OF 82

    Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy.
    Neurosci Biobehav Rev 2017 Jul 28. Epub 2017 Jul 28.
    Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany. Electronic address:
    Accumulating research shows that prenatal exposure to maternal stress increases the risk for behavioral and mental health problems later in life. This review systematically analyzes the available human studies to identify harmful stressors, vulnerable periods during pregnancy, specificities in the outcome and biological correlates of the relation between maternal stress and offspring outcome. Effects of maternal stress on offspring neurodevelopment, cognitive development, negative affectivity, difficult temperament and psychiatric disorders are shown in numerous epidemiological and case-control studies. Read More

    Corticotropin-Releasing Hormone As the Homeostatic Rheostat of Feto-Maternal Symbiosis and Developmental Programming In Utero and Neonatal Life.
    Front Endocrinol (Lausanne) 2017 11;8:161. Epub 2017 Jul 11.
    Translational Medicine, Warwick Medical School, Coventry, United Kingdom.
    A balanced interaction between the homeostatic mechanisms of mother and the developing organism during pregnancy and in early neonatal life is essential in order to ensure optimal fetal development, ability to respond to various external and internal challenges, protection from adverse programming, and safeguard maternal care availability after parturition. In the majority of pregnancies, this relationship is highly effective resulting in successful outcomes. However, in a number of pathological settings, perturbations of the maternal homeostasis disrupt this symbiosis and initiate adaptive responses with unpredictable outcomes for the fetus or even the neonate. Read More

    Exposure to intimate partner violence in utero and infant internalizing behaviors: Moderation by salivary cortisol-alpha amylase asymmetry.
    Early Hum Dev 2017 Jul 20;113:40-48. Epub 2017 Jul 20.
    Department of Psychology, Michigan State University, USA.
    Guided by the main tenets of contemporary models of the developmental origins of health and disease, this study evaluated whether individual differences in reactivity of the hypothalamic-pituitary-adrenal (HPA) axis and Sympathetic Nervous System (SNS) moderate the effect of prenatal exposure to trauma on internalizing and externalizing behaviors during infancy. Participants were a community sample of 182 mothers (M age=25years, 43% Caucasian, 33% Black/African American, 24% Biracial/Other) and their infants (59% girls; M age=11.8months). Read More

    Non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency revisited: an update with a special focus on adolescent and adult women.
    Hum Reprod Update 2017 Jun 5:1-20. Epub 2017 Jun 5.
    Departments of Obstetrics/Gynecology, and Medicine, Augusta University, Augusta, GA, USA.
    Background: Non-classic congenital hyperplasia (NCAH) due to 21-hydroxylase deficiency is a common autosomal recessive disorder characterized by androgen excess.

    Objective And Rationale: We conducted a systematic review and critical assessment of the available evidence pertaining to the epidemiology, pathophysiology, diagnosis and management of NCAH. A meta-analysis of epidemiological data was also performed. Read More

    Mechanisms of Glucocorticoid Action During Development.
    Curr Top Dev Biol 2017 16;125:147-170. Epub 2017 Jan 16.
    Molecular Endocrinology Group, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, United States. Electronic address:
    Glucocorticoids are primary stress hormones produced by the adrenal cortex. The concentration of serum glucocorticoids in the fetus is low throughout most of gestation but surge in the weeks prior to birth. While their most well-known function is to stimulate differentiation and functional development of the lungs, glucocorticoids also play crucial roles in the development of several other organ systems. Read More

    Neurobehavioral risks of SSRIs in pregnancy: Comparing human and animal data.
    Reprod Toxicol 2017 May 8. Epub 2017 May 8.
    Laboratory of Teratology, Department of Medical Neurobiology, Hebrew University Hadassah Medical School, Jerusalem, Israel. Electronic address:
    During the last twenty years, in spite of extensive literature regarding the use of SSRIs in pregnancy, confusion still exists as to possible long-term risks of these drugs on the offspring. Possible negative effects relate to neurodevelopmental outcome and association with Autism Spectrum Disorder (ASD). Most neurodevelopmental follow up studies did not find significant cognitive impairment except from some apparently transient, gross motor delay and slight impairment of language abilities. Read More

    Management of a multiple endocrine neoplasia type 1 during pregnancy: A case report and review of the literature.
    J Exp Ther Oncol 2016 Jul;11(3):217-220
    Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
    Multiple Endocrine Neoplasia Type 1 (MEN1) or Wermer's syndrome is a rare hereditary endocrine syndrome with high penetrance caused by mutations in MEN1 tumor suppressor gene. MEN1 is characterized by hyperplasia or tumoral enlargement in a number of endocrine organs (parathyroid glands, pancreas, pituitary gland, adrenal gland) and it could be hormonally active or inactive. MEN1 is a significant cause of morbidity due to hormone secretion and mass effect. Read More

    Pregnancy outcomes in women with different doses of corticosteroid supplementation during labor and delivery.
    J Obstet Gynaecol Res 2017 Jul 19;43(7):1132-1138. Epub 2017 Apr 19.
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.
    Aim: The aim of this study was to report the pregnancy outcomes of women who received different doses of corticosteroid supplementation during labor and delivery.

    Methods: We conducted a retrospective review of 102 pregnant women who received oral corticosteroid therapy, delivered at Osaka University Hospital, and were administered intravenous corticosteroid supplementation during labor and delivery. From January 2008 to May 2012, 47 women were administered a high dose of corticosteroids (HD group). Read More

    Life-threatening endocrine emergencies during pregnancy - management and therapeutic features.
    Gynecol Endocrinol 2017 Mar 31:1-5. Epub 2017 Mar 31.
    b Department of Medicine II , University of Lübeck , Lübeck , Germany.
    Endocrine emergencies during pregnancy may be life-threatening events for both mother and fetus. Besides pregnancy-associated endocrine disorders, several pre-existing endocrinopathies such as type-1 diabetes and Grave's disease or adrenal failure may acutely deteriorate during pregnancy. Since "classical" signs are often modified by pregnancy, early diagnosis and management may be hampered. Read More

    Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.
    Cochrane Database Syst Rev 2017 03 21;3:CD004454. Epub 2017 Mar 21.
    Liggins Institute, The University of Auckland, Park Rd, Grafton, Auckland, New Zealand, 1142.
    Background: Respiratory morbidity including respiratory distress syndrome (RDS) is a serious complication of preterm birth and the primary cause of early neonatal mortality and disability. While researching the effects of the steroid dexamethasone on premature parturition in fetal sheep in 1969, Liggins found that there was some inflation of the lungs of lambs born at gestations at which the lungs would be expected to be airless. Liggins and Howie published the first randomised controlled trial in humans in 1972 and many others followed. Read More

    A successful case of pregnancy in a woman with ACTH-independent Cushing's syndrome treated with ketoconazole and metyrapone.
    Gynecol Endocrinol 2017 May 26;33(5):349-352. Epub 2017 Feb 26.
    b Department of Clinical Endocrinology and Metabolic Disease , Polish Mother's Memorial Hospital Research Institute , Lodz , Poland.
    Cushing's syndrome (CS) is a rare disease caused by a chronic excess of cortisol. Hypercortisolaemia may affect reproductive system leading to infertility in women. However, some of the patients remain fertile, although pregnancy is uncommon. Read More

    Transfer of maternal psychosocial stress to the fetus.
    Neurosci Biobehav Rev 2017 Feb 22. Epub 2017 Feb 22.
    Hans Berger Department of Neurology, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany. Electronic address:
    Psychosocial maternal stress experienced during different vulnerable periods throughout gestation is thought to increase the individual's risk to develop neuropsychiatric, cardiovascular and metabolic disease in later life. Cortisol has generally been identified as the major mediator of maternal stress transfer to the fetus. Its lipophilic nature allows a trans-placental passage and thus excessive maternal cortisol could persistently impair the development of the fetal hypothalamic-pituitary-adrenal axis (HPAA). Read More

    Sex-Specific Neurodevelopmental Programming by Placental Insulin Receptors on Stress Reactivity and Sensorimotor Gating.
    Biol Psychiatry 2017 Jul 30;82(2):127-138. Epub 2016 Dec 30.
    Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
    Background: Diabetes, obesity, and overweight are prevalent pregnancy complications that predispose offspring to neurodevelopmental disorders, including autism, attention-deficit/hyperactivity disorder, and schizophrenia. Although male individuals are three to four times more likely than female individuals to develop these disorders, the mechanisms driving the sex specificity of disease vulnerability remain unclear. Because defective placental insulin receptor (InsR) signaling is a hallmark of pregnancy metabolic dysfunction, we hypothesized that it may be an important contributor and novel mechanistic link to sex-specific neurodevelopmental changes underlying disease risk. Read More

    [Tetraparesis revealing Conn adenoma in a pregnant woman].
    Pan Afr Med J 2016 27;25:24. Epub 2016 Sep 27.
    Service de Médecine Interne, Hôpital Militaire d'Instruction Mohammed V, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.
    We report the case of Conn adenoma revealed by tetraparesis in a 33-year old pregnant woman at the 16(th)week of amenorrhea. The patient had a blood pressure of 147/87 mmHg, which was considered high-normal, hypokalemia at 1.1 mmol/l. Read More

    Case Report: Acute Flair of Ulcerative Colitis during Pregnancy Is Still a Major Problem.
    Dig Dis 2017 1;35(1-2):134-138. Epub 2017 Feb 1.
    Department of Gastroenterology, University Hospital Zvezdara, Belgrade, Serbia.
    Although severe flare of ulcerative colitis (UC) is uncommon, it significantly increases the risk of preterm delivery, low birth weight and other adverse fetal outcomes. It is critical to optimize aggressive medical treatment with both mother and fetal health. Here, we present a case of a 30-year-old woman with a severe flare of UC at the 16th gestational week. Read More

    Combined Effects of Gestational Phthalate Exposure and Zinc Deficiency on Steroid Metabolism and Growth.
    Toxicol Sci 2017 Apr;156(2):469-479
    Departments of Nutrition and of Environmental Toxicology, University of California, Davis, California 95616.
    Disruption of steroid hormone signaling has been implicated independently in the developmental abnormalities resulting from maternal phthalate plasticizer exposure and developmental zinc deficiency. This study investigated if secondary zinc deficiency may result from dietary exposure to a low level of di-2-ethylhexyl phthalate (DEHP) through gestation and if this could be associated with altered steroid metabolism. The interaction between marginal zinc nutrition and DEHP exposure to affect pregnancy outcome, zinc status, and steroid metabolism was also assessed. Read More

    Hypertension: The role of biochemistry in the diagnosis and management.
    Clin Chim Acta 2017 Feb 19;465:131-143. Epub 2016 Dec 19.
    Dept. of Clinical Biochemistry & Diagnostic Endocrinology, Mater Misericordiae University Hospital, Dublin, Ireland.
    Hypertension is defined as a persistently elevated blood pressure ≥140/90mmHg. It is an important treatable risk factor for cardiovascular disease, with a high prevalence in the general population. The most common cause, essential hypertension, is a widespread disease - however, secondary hypertension is under investigated and under diagnosed. Read More

    Former Very Preterm Infants Show an Unfavorable Cardiovascular Risk Profile at a Preschool Age.
    PLoS One 2016 13;11(12):e0168162. Epub 2016 Dec 13.
    Department of Pediatrics, Pediatrics II (Neonatology), Medical University of Innsbruck, Innsbruck, Austria.
    Cardiovascular disease is the leading cause of death worldwide. Evidence points towards an unfavorable cardiovascular risk profile of former preterm infants in adolescence and adulthood. The aim of this study was to determine whether cardiovascular risk predictors are detectable in former very preterm infants at a preschool age. Read More

    Mortality in patients with diabetes mellitus and Addison's disease: a nationwide, matched, observational cohort study.
    Eur J Endocrinol 2017 Jan;176(1):31-39
    Department of Internal Medicine and Clinical NutritionInstitute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Objective: Our hypothesis was that patients with diabetes mellitus obtain an additional risk of death if they develop Addison's disease (AD).

    Design And Methods: Nationwide, matched, observational cohort study cross-referencing the Swedish National Diabetes Register with Inpatient, Cancer and Cause of Death Registers in patients with diabetes (type 1 and 2) and AD and matched controls with diabetes. Clinical characteristics at baseline, overall, and cause-specific mortality were assessed. Read More

    Adrenalectomy for Cushing's syndrome: do's and don'ts.
    J Med Life 2016 Oct-Dec;9(4):334-341
    "I. Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Endocrinology, Clinical County Hospital, Cluj-Napoca, Romania.
    Aim. To present specific aspects of adrenalectomy for Cushing's syndrome (CS) by introducing well established aspects ("do's") and less known aspects ("don'ts"). Material and Method. Read More

    Thirty-Eight-Year Follow-Up of Two Sibling Lipoid Congenital Adrenal Hyperplasia Patients Due to Homozygous Steroidogenic Acute Regulatory (STARD1) Protein Mutation. Molecular Structure and Modeling of the STARD1 L275P Mutation.
    Front Neurosci 2016 21;10:527. Epub 2016 Nov 21.
    Department of Biochemistry, Faculty of Medicine, University of Sherbrooke Sherbrooke, QC, Canada.
    Objective: Review the impact of StAR (STARD1) mutations on steroidogenesis and fertility in LCAH patients. Examine the endocrine mechanisms underlying the pathology of the disorder and the appropriate therapy for promoting fertility and pregnancies. Design: Published data in the literature and a detailed 38-year follow-up of two sibling LCAH patients. Read More

    Pheochromocytoma in neurofibromatosis type 1 during pregnancy.
    Gynecol Endocrinol 2017 Feb 2;33(2):93-95. Epub 2016 Dec 2.
    a Department of Endocrinology and Nutrition , Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla , Seville , Spain.
    Pregnant women with neurofibromatosis type 1 (NF-1) have increased complications during gestation, including hypertensive disorders that are sometimes caused by pheochromocytoma. Pheochromocytoma is an extremely rare condition during pregnancy, and the main clinical manifestation is hypertension. If not properly treated, pheochromocytoma has high maternal and fetal mortality rates. Read More

    Maternal epigenetics and fetal and neonatal growth.
    Curr Opin Endocrinol Diabetes Obes 2017 Feb;24(1):43-46
    Department of Medical Genetics, Medical School, National and Kapodistrian University of Athens, Greece.
    Purpose Of Review: The article provides an update on new insights of factors altering inherited maternal epigenome that ultimately affect fetal and neonatal growth.

    Recent Findings: A number of new publications have identified mechanisms through which maternal nutrition, environmental exposures such as stress and toxic substances altering expression of imprinted genes during pregnancy can influence fetal and neonatal phenotype and susceptibility to disease development later in life. The possible causes of metabolic syndrome by in-utero epigenetic alterations of genes involved in energy metabolism (PPARγ and PPARα), microRNAs, arginine methyltransferases, lysine demethylases, and histone deacetylaces have been elucidated. Read More

    [Adrenocortical oncocytoma presenting as Cushing´s syndrome in pregnancy with spontaneous postpartum uterine rupture].
    Ceska Gynekol 2016 ;81(3):228-232
    Objective: The description of rare case of the Cushings syndrome in pregnancy resulting in the spontaneous rupture of uterus.

    Designs: A case report.

    Setting: Department of Gynecology and Obstetrics, 1st Medical Faculty of Charles University and Hospital Na Bulovce. Read More

    Fetal Exposure to Low Levels of the Plasticizer DEHP Predisposes the Adult Male Adrenal Gland to Endocrine Disruption.
    Endocrinology 2017 02;158(2):304-318
    Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada
    In utero exposure to endocrine disrupting chemicals (EDCs) may affect adult health. Di-(2-ethylhexyl) phthalate (DEHP) is an EDC widely used in the production of polyvinyl chloride products and an ubiquitous environmental contaminant. We used a rat model system to show that fetal exposure to DEHP decreased levels of major steroid hormones in adulthood and that environmentally-relevant levels of DEHP affected both gene expression and epigenomic loci that were affected by exposure to high levels. Read More

    Surfactant Protein A and B Gene Polymorphisms and Risk of Respiratory Distress Syndrome in Late-Preterm Neonates.
    PLoS One 2016 11;11(11):e0166516. Epub 2016 Nov 11.
    Neonatal Intensive Care Unit, Department of Pediatrics, Faculty of Medicine, University of Patras, Rio, Patras, Greece.
    Background And Objectives: Newborns delivered late-preterm (between 340/7 and 366/7 weeks of gestation) are at increased risk of respiratory distress syndrome (RDS). Polymorphisms within the surfactant protein (SP) A and B gene have been shown to predispose to RDS in preterm neonates. The aim of this study was to investigate whether specific SP-A and/or SP-B genetic variants are also associated with RDS in infants born late-preterm. Read More

    A successfully treated case of cardiac arrest after Caesarean section complicated by pheochromocytoma crisis and amniotic fluid embolism.
    J Anesth 2017 Feb 10;31(1):140-143. Epub 2016 Nov 10.
    Department of Intensive Care Unit, University of Fukui Hospital, 23-3 Matsuoka Shimoaizuki, Eiheijicho, Yoshidagun, Fukui, 910-1193, Japan.
    Both pheochromocytoma and amniotic fluid embolism (AFE) are important causes of maternal mortality. We present a case of a 29-year-old woman who developed cardiac arrest after Caesarean section, complicated by both pheochromocytoma crisis and AFE. After resuscitation, the patient developed multiple organ dysfunction, rhabdomyolysis and disseminated intravascular coagulation (DIC). Read More

    A design thinking approach to primary ovarian insufficiency.
    Panminerva Med 2017 Mar 9;59(1):15-32. Epub 2016 Nov 9.
    Division of Intramural Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA -
    Most clinicians are not prepared to provide integrated personal care to address all the clinical needs of women with primary ovarian insufficiency. Design thinking is an engineering methodology used to develop and evaluate novel concepts for systems operation. Here we articulate the need for a seamlessly integrated mobile health system to support genomic research as well as patient care. Read More

    Preconception management of endocrine disorders.
    J Pak Med Assoc 2016 Nov;66(11):1494-1496
    Department of Endocrinology, Bharti Hospital, Karnal, All India Institute of Medical Sciences, New Delhi, India.
    Endocrine function is closely interlinked with pregnancy. Maternal and foetal outcomes can be improved if optimal endocrine function is achieved, and maintained prior to conception. This needs a systematic approach which includes rational screening, appropriate management, and pragmatic counseling. Read More

    Recurrence of phaeochromocytoma in pregnancy in a patient with multiple endocrine neoplasia 2A: a case report and review of literature.
    Gynecol Endocrinol 2016 Nov 3;32(11):875-880. Epub 2016 Nov 3.
    d Consultant in Obstetrics and Gynaecology, Wrexham Maelor Hospital , Wales , UK.
    Multiple endocrine neoplasia type 2A (MEN 2A) is an autosomal dominant inherited condition with a prevalence of one in 40 000 individuals. It causes the development of tumours in endocrine glands, such as medullary thyroid cancer, pheochromocytomas, as well as primary hyperparathyroidism. MEN 2A in pregnancy is very rare with only 29 cases reported in the literature. Read More

    Long-term metabolic risk among children born premature or small for gestational age.
    Nat Rev Endocrinol 2017 Jan 19;13(1):50-62. Epub 2016 Aug 19.
    Dutch Growth Research Foundation, 3001 KB Rotterdam, The Netherlands.
    Accumulating evidence suggests that both the intrauterine environment and growth during early life can influence the development of chronic noncommunicable diseases, such as type 2 diabetes mellitus and cardiovascular disease, in adulthood. Here, we review the available human data supporting increased metabolic risk among children born premature or small for gestational age; the adrenal and pubertal modifications that contribute to this risk; metabolic changes that occur during adolescence and early adulthood; and approaches to potentially modify or decrease risk of metabolic disease. The risks associated with delivery at term or preterm are compared for each period of life. Read More

    Prenatal maternal depression is associated with offspring inflammation at 25 years: a prospective longitudinal cohort study.
    Transl Psychiatry 2016 Nov 1;6(11):e936. Epub 2016 Nov 1.
    Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
    Animal studies and a handful of prospective human studies have demonstrated that young offspring exposed to maternal prenatal stress show abnormalities in immune parameters and hypothalamic-pituitary-adrenal (HPA) axis function. No study has examined the effect of maternal prenatal depression on offspring inflammation and HPA axis activity in adulthood, nor the putative role of child maltreatment in inducing these abnormalities. High-sensitivity C-reactive protein (hs-CRP) and awakening cortisol were measured at age 25 in 103 young-adult offspring of the South London Child Development Study (SLCDS), a prospective longitudinal birth cohort of mother-offspring dyads recruited in pregnancy in 1986. Read More

    Sex-Specific Metabolic Outcomes in Offspring of Female Rats Born Small or Exposed to Stress During Pregnancy.
    Endocrinology 2016 Nov 29;157(11):4104-4120. Epub 2016 Aug 29.
    Department of Physiology (J.N.C., A.J.J., K.A., M.E.W.), Faculty of Medicine, Dentistry and Health Sciences, School of Biomedical Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia; School of Biomedical Sciences (J..S.M.C., K.M.M.), University of Queensland, St. Lucia, Queensland 4072, Australia; School of Medical Science (J.S.M.C.), Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia; and Department of Physiology (K.A.), Anatomy and Microbiology, La Trobe University, Bundoora, Victoria, 3086, Australia.
    Low birth weight increases adult metabolic disease risk in both the first (F1) and second (F2) generation. Physiological stress during pregnancy in F1 females that were born small induces F2 fetal growth restriction, but the long-term metabolic health of these F2 offspring is unknown. Uteroplacental insufficiency (restricted) or sham (control) surgery was performed in F0 rats. Read More

    Extracorporeal Membrane Oxygenation for Treatment of Acute Inverted Takotsubo-Like Cardiomyopathy From Hemorrhagic Pheochromocytoma in Late Pregnancy.
    A A Case Rep 2016 Nov;7(9):196-199
    From the *Institute for Anesthesiology & Intensive Care Medicine, Triemli Hospital, Zürich, Switzerland; and †Clinic for Cardiac Surgery, Triemli Hospital, Zürich, Switzerland.
    We describe the first case of a pregnant woman presenting with an acute inverted takotsubo-like cardiomyopathy caused by a postpartum diagnosed hemorrhagic pheochromocytoma, successfully treated with percutaneous venoarterial extracorporeal membrane oxygenation (va-ECMO). During admission, an emergency cesarean delivery had to be performed. The fetus needed resuscitation for 5 minutes. Read More

    Postpartum hypothalamic adrenal insufficiency with remission: A rare case.
    Endocr J 2017 Feb 25;64(2):157-162. Epub 2016 Oct 25.
    Department of Endocrinology and Diabetes Mellitus, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
    A 37-year-old female patient was hospitalized because of general fatigue and loss of axillary and pubic hair after massive bleeding at delivery of her third child. The basal levels of both plasma adrenocorticotropin hormone (ACTH) and serum cortisol were very low, 5.2 pg/mL and 1. Read More

    Preadolescent Adversity Programs a Disrupted Maternal Stress Reactivity in Humans and Mice.
    Biol Psychiatry 2017 Apr 26;81(8):693-701. Epub 2016 Aug 26.
    Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Penn PROMOTES Research on Sex and Gender in Health, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
    Background: Adverse childhood experiences (ACEs) are one of the greatest predictors of affective disorders for women. Periods of dynamic hormonal flux, including pregnancy, exacerbate the risk for affective disturbance and promote hypothalamic-pituitary-adrenal (HPA) axis dysregulation, a key feature of affective disorders. Little is understood as to how stress experienced in late childhood, defined as preadolescence, alters the programming unique to this period of brain maturation and its interaction with the hormonal changes of pregnancy and postpartum. Read More

    Disorders of Sexual Development in Adult Women.
    Obstet Gynecol 2016 Nov;128(5):1162-1173
    MedStar Washington Hospital Center/Children's National Medical Center, Washington, DC; and the University of Washington School of Medicine, Seattle, Washington.
    Disorders (differences) of sexual development encompass a variety of conditions with atypical development of chromosomal, gonadal, or anatomic sex. Three of the most common differences of sex development conditions include congenital adrenal hyperplasia, complete androgen insensitivity, and Turner syndrome. Obstetrician-gynecologists who care for affected individuals in their practice must be familiar with the genetic, endocrine, and anatomic considerations of the most common conditions to provide optimal care. Read More

    Prenatal corticosterone exposure programs sex-specific adrenal adaptations in mouse offspring.
    J Endocrinol 2017 Jan 17;232(1):37-48. Epub 2016 Oct 17.
    School of Biomedical ScienceThe University of Queensland, St Lucia, Queensland, Australia
    Maternal stress can impair foetal development and program sex-specific disease outcomes in offspring through the actions of maternally produced glucocorticoids, predominantly corticosterone (Cort) in rodents. We have demonstrated in mice that male but not female offspring prenatally exposed to Cort (33 µg/kg/h for 60 h beginning at E12.5) develop cardiovascular/renal dysfunction at 12 months. Read More

    A novel variant in the SLC12A1 gene in two families with antenatal Bartter syndrome.
    Acta Paediatr 2017 Jan;106(1):161-167
    Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.
    Aim: Bartter syndrome is an autosomal-recessive inherited disease in which patients present with hypokalaemia and metabolic alkalosis. We present two apparently nonrelated cases with antenatal Bartter syndrome type I, due to a novel variant in the SLC12A1 gene encoding the bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 in the thick ascending limb of the loop of Henle.

    Methods: Blood samples were received from the two cases and 19 of their relatives, and deoxyribonucleic acid was extracted. Read More

    Preterm birth in women with inflammatory bowel disease - the association with disease activity and drug treatment.
    Scand J Gastroenterol 2016 Dec 18;51(12):1462-1469. Epub 2016 Jul 18.
    a Unit of Clinical Epidemiology , Centre for Pharmacoepidemiology, Karolinska Institutet , Stockholm , Sweden.
    Background: The inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC) have been associated with an increased risk of preterm birth.

    Material And Methods: We identified all 246 singleton preterm births among women with IBD between July 2006 and December 2010 as cases and an equal number of controls with IBD from the Swedish national health registers, matched by maternal age, parity and IBD diagnosis (CD/UC). From register data and medical charts, we obtained information on reproductive history, comorbidity, disease activity and drug treatment (corticosteroids, 5-aminosalicylates, sulfasalazine, thiopurines and anti-TNF) as risk factors for preterm birth. Read More

    Cushing's syndrome and pregnancy outcomes: a systematic review of published cases.
    Endocrine 2017 Feb 4;55(2):555-563. Epub 2016 Oct 4.
    Endocrinology/Medicine Departments, Hospital Sant Pau, Barcelona, Spain.
    Pregnancy in Cushing's syndrome (CS) is extremely rare due to the influence of hypercortisolism on the reproductive axis. Purpose of this study is to investigate whether the etiology of CS in pregnancy determines a different impact on the fetal/newborn and maternal outcomes. We performed a systematic review of cases published in the literature from January 1952 to April 2015 including the words "Cushing AND pregnancy". Read More

    Impact of maternal steroids during pregnancy.
    Ann Endocrinol (Paris) 2016 Dec 16;77(6):677-679. Epub 2016 Sep 16.
    Endocrinology unit, centre for cardiovascular science, Queen's medical research institute, 47, Little France Crescent, EH16 4TJ Edinburgh, United Kingdom. Electronic address:
    Increased fetal exposure to glucocorticoids is a key mechanism thought to underlie the early life programming of later life disease. There is substantial experimental data in animal models in support of this hypothesis. Emerging evidence suggests glucocorticoid programming may also occur in humans with some studies now linking maternal endogenous cortisol levels with size at birth and gestation at delivery. Read More

    [Gene mutation analysis and prenatal diagnosis of a family with Bartter syndrome].
    Zhongguo Dang Dai Er Ke Za Zhi 2016 Aug;18(8):746-50
    Xiangya School of Medicine, Central South University, Changsha 410008, China.
    Objective: To investigate the mutation of related genes and prenatal diagnosis of a family with Bartter syndrome (BS).

    Methods: The high-throughput capture sequencing technique and PCR-Sanger sequencing were used to detect pathogenic genes in the proband of this family and analyze the whole family at the genomic level. After the genetic cause was clarified, the amniotic fluid was collected from the proband's mother who was pregnant for 5 months for prenatal diagnosis. Read More

    Sex-Dimorphic Effects of Prenatal Treatment With Dexamethasone.
    J Clin Endocrinol Metab 2016 Oct 2;101(10):3838-3846. Epub 2016 Aug 2.
    Department of Women's and Children's Health (L.W., M.Z., M.T.S., A.G., A.N., S.L.), Karolinska Institutet, Pediatric Endocrinology Unit (Q2:08), Karolinska University Hospital, and Department of Women's and Children's Health (T.H.), Karolinska Institutet, Center of Neurodevelopmental Disorders at Karolinska Institutet (KIND), Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
    Context: Dexamethasone (DEX) is used to prevent virilization in female fetuses at risk of congenital adrenal hyperplasia (CAH). Given that treatment has to be started before the genotype is known, 7 out of 8 fetuses will be exposed to DEX without benefit.

    Objective: To evaluate long-term cognitive effects of prenatal DEX therapy in healthy (non-CAH) DEX-treated children. Read More

    Steroid 21-hydroxylase deficiency in congenital adrenal hyperplasia.
    J Steroid Biochem Mol Biol 2017 Jan 2;165(Pt A):2-11. Epub 2016 Jul 2.
    Adrenal Steroid Disorders Program, Icahn School of Medicine at Mount Sinai, Manhattan, NY, United States.
    Congenital adrenal hyperplasia (CAH) refers to a group of inherited genetic disorders involving deficiencies in enzymes that convert cholesterol to cortisol within the adrenal cortex. There are five key enzymes involved in the production of cortisol. Of these key enzymes, deficiency of 21-hydroxylase is the most commonly defective enzyme leading to CAH representing more than 90% of cases. Read More

    New developments in prenatal diagnosis of congenital adrenal hyperplasia.
    J Steroid Biochem Mol Biol 2017 Jan 1;165(Pt A):121-123. Epub 2016 Jul 1.
    Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1055, New York, NY 10029, USA. Electronic address:
    Congenital adrenal hyperplasia (CAH) owing to 21-hydroxylase deficiency is an autosomal recessive disorder caused by mutations in the CYP21A2 gene. Females affected with classical CAH are at risk for genital ambiguity, but can be treated in utero with dexamethasone before 9 gestational weeks to prevent virilization. Early genetic diagnosis is unavailable through current invasive methods of chorionic villus sampling and amniocentesis. Read More

    Diagnosis and treatment of adrenal insufficiency including adrenal crisis: a Japan Endocrine Society clinical practice guideline [Opinion].
    Endocr J 2016 Sep 24;63(9):765-784. Epub 2016 Jun 24.
    Department of Endocrinology and Diabetes Mellitus, Faculty of Medicine, Fukuoka University, Fukuoa 814-0180, Japan.
    This clinical practice guideline of the diagnosis and treatment of adrenal insufficiency (AI) including adrenal crisis was produced on behalf of the Japan Endocrine Society. This evidence-based guideline was developed by a committee including all authors, and was reviewed by a subcommittee of the Japan Endocrine Society. The Japanese version has already been published, and the essential points have been summarized in this English language version. Read More

    Isolated subdiaphragmatic extralobar pulmonary sequestration: masquerading as suprarenal mass with spontaneous resolution.
    Clin Exp Obstet Gynecol 2016 ;43(3):457-9
    Sub-diaphragmatic extralobar pulmonary sequestration (PS) is an extremely rare malformation defined as a portion of lung tissue that is totally discontinuous from the tracheobronchial tree and usually has its own pleural covering with an anomalous systemic blood supply. It is usually associated with other congenital malformations. The authors present an extremely rare case of isolated sub-diaphragmatic PS which was antenatally detected and followed up with postnatal ultrasound, where it masqueraded as a suprarenal mass; it was totally asymptomatic with spontaneous resolution at age of two years. Read More

    1 OF 82