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    4021 results match your criteria Adrenal Disease and Pregnancy

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    Sex-Specific Neurodevelopmental Programming by Placental Insulin Receptors on Stress Reactivity and Sensorimotor Gating.
    Biol Psychiatry 2016 Dec 30. Epub 2016 Dec 30.
    Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
    Background: Diabetes, obesity, and overweight are prevalent pregnancy complications that predispose offspring to neurodevelopmental disorders, including autism, attention-deficit/hyperactivity disorder, and schizophrenia. Although male individuals are three to four times more likely than female individuals to develop these disorders, the mechanisms driving the sex specificity of disease vulnerability remain unclear. Because defective placental insulin receptor (InsR) signaling is a hallmark of pregnancy metabolic dysfunction, we hypothesized that it may be an important contributor and novel mechanistic link to sex-specific neurodevelopmental changes underlying disease risk. Read More

    Case Report: Acute Flair of Ulcerative Colitis during Pregnancy Is Still a Major Problem.
    Dig Dis 2017 1;35(1-2):134-138. Epub 2017 Feb 1.
    Department of Gastroenterology, University Hospital Zvezdara, Belgrade, Serbia.
    Although severe flare of ulcerative colitis (UC) is uncommon, it significantly increases the risk of preterm delivery, low birth weight and other adverse fetal outcomes. It is critical to optimize aggressive medical treatment with both mother and fetal health. Here, we present a case of a 30-year-old woman with a severe flare of UC at the 16th gestational week. Read More

    Combined Effects of Gestational Phthalate Exposure and Zinc Deficiency on Steroid Metabolism and Growth.
    Toxicol Sci 2017 Jan 23. Epub 2017 Jan 23.
    Departments of Nutrition and of Environmental Toxicology, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
    Disruption of steroid hormone signaling has been implicated independently in the developmental abnormalities resulting from maternal phthalate plasticizer exposure and developmental zinc deficiency. This study investigated if secondary zinc deficiency may result from dietary exposure to a low level of DEHP through gestation and if this could be associated with altered steroid metabolism. The interaction between marginal zinc nutrition and DEHP exposure to affect pregnancy outcome, zinc status, and steroid metabolism was also assessed. Read More

    Hypertension: The role of biochemistry in the diagnosis and management.
    Clin Chim Acta 2017 Feb 19;465:131-143. Epub 2016 Dec 19.
    Dept. of Clinical Biochemistry & Diagnostic Endocrinology, Mater Misericordiae University Hospital, Dublin, Ireland.
    Hypertension is defined as a persistently elevated blood pressure ≥140/90mmHg. It is an important treatable risk factor for cardiovascular disease, with a high prevalence in the general population. The most common cause, essential hypertension, is a widespread disease - however, secondary hypertension is under investigated and under diagnosed. Read More

    Mortality in patients with diabetes mellitus and Addison's disease: a nationwide, matched, observational cohort study.
    Eur J Endocrinol 2017 Jan;176(1):31-39
    Department of Internal Medicine and Clinical NutritionInstitute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Objective: Our hypothesis was that patients with diabetes mellitus obtain an additional risk of death if they develop Addison's disease (AD).

    Design And Methods: Nationwide, matched, observational cohort study cross-referencing the Swedish National Diabetes Register with Inpatient, Cancer and Cause of Death Registers in patients with diabetes (type 1 and 2) and AD and matched controls with diabetes. Clinical characteristics at baseline, overall, and cause-specific mortality were assessed. Read More

    Thirty-Eight-Year Follow-Up of Two Sibling Lipoid Congenital Adrenal Hyperplasia Patients Due to Homozygous Steroidogenic Acute Regulatory (STARD1) Protein Mutation. Molecular Structure and Modeling of the STARD1 L275P Mutation.
    Front Neurosci 2016 21;10:527. Epub 2016 Nov 21.
    Department of Biochemistry, Faculty of Medicine, University of Sherbrooke Sherbrooke, QC, Canada.
    Objective: Review the impact of StAR (STARD1) mutations on steroidogenesis and fertility in LCAH patients. Examine the endocrine mechanisms underlying the pathology of the disorder and the appropriate therapy for promoting fertility and pregnancies. Design: Published data in the literature and a detailed 38-year follow-up of two sibling LCAH patients. Read More

    Maternal epigenetics and fetal and neonatal growth.
    Curr Opin Endocrinol Diabetes Obes 2017 Feb;24(1):43-46
    Department of Medical Genetics, Medical School, National and Kapodistrian University of Athens, Greece.
    Purpose Of Review: The article provides an update on new insights of factors altering inherited maternal epigenome that ultimately affect fetal and neonatal growth.

    Recent Findings: A number of new publications have identified mechanisms through which maternal nutrition, environmental exposures such as stress and toxic substances altering expression of imprinted genes during pregnancy can influence fetal and neonatal phenotype and susceptibility to disease development later in life. The possible causes of metabolic syndrome by in-utero epigenetic alterations of genes involved in energy metabolism (PPARγ and PPARα), microRNAs, arginine methyltransferases, lysine demethylases, and histone deacetylaces have been elucidated. Read More

    [Adrenocortical oncocytoma presenting as Cushing´s syndrome in pregnancy with spontaneous postpartum uterine rupture].
    Ceska Gynekol 2016 ;81(3):228-232
    Objective: The description of rare case of the Cushings syndrome in pregnancy resulting in the spontaneous rupture of uterus.

    Designs: A case report.

    Setting: Department of Gynecology and Obstetrics, 1st Medical Faculty of Charles University and Hospital Na Bulovce. Read More

    Preconception management of endocrine disorders.
    J Pak Med Assoc 2016 Nov;66(11):1494-1496
    Department of Endocrinology, Bharti Hospital, Karnal, All India Institute of Medical Sciences, New Delhi, India.
    Endocrine function is closely interlinked with pregnancy. Maternal and foetal outcomes can be improved if optimal endocrine function is achieved, and maintained prior to conception. This needs a systematic approach which includes rational screening, appropriate management, and pragmatic counseling. Read More

    Prenatal maternal depression is associated with offspring inflammation at 25 years: a prospective longitudinal cohort study.
    Transl Psychiatry 2016 Nov 1;6(11):e936. Epub 2016 Nov 1.
    Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
    Animal studies and a handful of prospective human studies have demonstrated that young offspring exposed to maternal prenatal stress show abnormalities in immune parameters and hypothalamic-pituitary-adrenal (HPA) axis function. No study has examined the effect of maternal prenatal depression on offspring inflammation and HPA axis activity in adulthood, nor the putative role of child maltreatment in inducing these abnormalities. High-sensitivity C-reactive protein (hs-CRP) and awakening cortisol were measured at age 25 in 103 young-adult offspring of the South London Child Development Study (SLCDS), a prospective longitudinal birth cohort of mother-offspring dyads recruited in pregnancy in 1986. Read More

    Sex-Specific Metabolic Outcomes in Offspring of Female Rats Born Small or Exposed to Stress During Pregnancy.
    Endocrinology 2016 Nov 29;157(11):4104-4120. Epub 2016 Aug 29.
    Department of Physiology (J.N.C., A.J.J., K.A., M.E.W.), Faculty of Medicine, Dentistry and Health Sciences, School of Biomedical Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia; School of Biomedical Sciences (J..S.M.C., K.M.M.), University of Queensland, St. Lucia, Queensland 4072, Australia; School of Medical Science (J.S.M.C.), Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia; and Department of Physiology (K.A.), Anatomy and Microbiology, La Trobe University, Bundoora, Victoria, 3086, Australia.
    Low birth weight increases adult metabolic disease risk in both the first (F1) and second (F2) generation. Physiological stress during pregnancy in F1 females that were born small induces F2 fetal growth restriction, but the long-term metabolic health of these F2 offspring is unknown. Uteroplacental insufficiency (restricted) or sham (control) surgery was performed in F0 rats. Read More

    Extracorporeal Membrane Oxygenation for Treatment of Acute Inverted Takotsubo-Like Cardiomyopathy From Hemorrhagic Pheochromocytoma in Late Pregnancy.
    A A Case Rep 2016 Nov;7(9):196-199
    From the *Institute for Anesthesiology & Intensive Care Medicine, Triemli Hospital, Zürich, Switzerland; and †Clinic for Cardiac Surgery, Triemli Hospital, Zürich, Switzerland.
    We describe the first case of a pregnant woman presenting with an acute inverted takotsubo-like cardiomyopathy caused by a postpartum diagnosed hemorrhagic pheochromocytoma, successfully treated with percutaneous venoarterial extracorporeal membrane oxygenation (va-ECMO). During admission, an emergency cesarean delivery had to be performed. The fetus needed resuscitation for 5 minutes. Read More

    Preadolescent Adversity Programs a Disrupted Maternal Stress Reactivity in Humans and Mice.
    Biol Psychiatry 2016 Aug 26. Epub 2016 Aug 26.
    Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Penn PROMOTES Research on Sex and Gender in Health, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
    Background: Adverse childhood experiences (ACEs) are one of the greatest predictors of affective disorders for women. Periods of dynamic hormonal flux, including pregnancy, exacerbate the risk for affective disturbance and promote hypothalamic-pituitary-adrenal (HPA) axis dysregulation, a key feature of affective disorders. Little is understood as to how stress experienced in late childhood, defined as preadolescence, alters the programming unique to this period of brain maturation and its interaction with the hormonal changes of pregnancy and postpartum. Read More

    J Hypertens 2016 Sep;34 Suppl 1 - ISH 2016 Abstract Book:e14-e15
    Yokohama City University Graduate School of Medicine, Japan.
    Primary aldosteronism (PA) is a heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most frequent endocrine cause of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension.Here I review the recent progress in understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA. Read More

    Cushing's syndrome and pregnancy outcomes: a systematic review of published cases.
    Endocrine 2017 Feb 4;55(2):555-563. Epub 2016 Oct 4.
    Endocrinology/Medicine Departments, Hospital Sant Pau, Barcelona, Spain.
    Pregnancy in Cushing's syndrome (CS) is extremely rare due to the influence of hypercortisolism on the reproductive axis. Purpose of this study is to investigate whether the etiology of CS in pregnancy determines a different impact on the fetal/newborn and maternal outcomes. We performed a systematic review of cases published in the literature from January 1952 to April 2015 including the words "Cushing AND pregnancy". Read More

    Impact of maternal steroids during pregnancy.
    Ann Endocrinol (Paris) 2016 Dec 16;77(6):677-679. Epub 2016 Sep 16.
    Endocrinology unit, centre for cardiovascular science, Queen's medical research institute, 47, Little France Crescent, EH16 4TJ Edinburgh, United Kingdom. Electronic address:
    Increased fetal exposure to glucocorticoids is a key mechanism thought to underlie the early life programming of later life disease. There is substantial experimental data in animal models in support of this hypothesis. Emerging evidence suggests glucocorticoid programming may also occur in humans with some studies now linking maternal endogenous cortisol levels with size at birth and gestation at delivery. Read More

    [Gene mutation analysis and prenatal diagnosis of a family with Bartter syndrome].
    Zhongguo Dang Dai Er Ke Za Zhi 2016 Aug;18(8):746-50
    Xiangya School of Medicine, Central South University, Changsha 410008, China.
    Objective: To investigate the mutation of related genes and prenatal diagnosis of a family with Bartter syndrome (BS).

    Methods: The high-throughput capture sequencing technique and PCR-Sanger sequencing were used to detect pathogenic genes in the proband of this family and analyze the whole family at the genomic level. After the genetic cause was clarified, the amniotic fluid was collected from the proband's mother who was pregnant for 5 months for prenatal diagnosis. Read More

    Diagnosis and treatment of adrenal insufficiency including adrenal crisis: a Japan Endocrine Society clinical practice guideline [Opinion].
    Endocr J 2016 Sep 24;63(9):765-784. Epub 2016 Jun 24.
    Department of Endocrinology and Diabetes Mellitus, Faculty of Medicine, Fukuoka University, Fukuoa 814-0180, Japan.
    This clinical practice guideline of the diagnosis and treatment of adrenal insufficiency (AI) including adrenal crisis was produced on behalf of the Japan Endocrine Society. This evidence-based guideline was developed by a committee including all authors, and was reviewed by a subcommittee of the Japan Endocrine Society. The Japanese version has already been published, and the essential points have been summarized in this English language version. Read More

    Isolated subdiaphragmatic extralobar pulmonary sequestration: masquerading as suprarenal mass with spontaneous resolution.
    Clin Exp Obstet Gynecol 2016 ;43(3):457-9
    Sub-diaphragmatic extralobar pulmonary sequestration (PS) is an extremely rare malformation defined as a portion of lung tissue that is totally discontinuous from the tracheobronchial tree and usually has its own pleural covering with an anomalous systemic blood supply. It is usually associated with other congenital malformations. The authors present an extremely rare case of isolated sub-diaphragmatic PS which was antenatally detected and followed up with postnatal ultrasound, where it masqueraded as a suprarenal mass; it was totally asymptomatic with spontaneous resolution at age of two years. Read More

    Diagnosis of antenatal Bartter syndrome.
    Clin Exp Obstet Gynecol 2016 ;43(3):453-4
    Established Facts: Bartter syndrome is a rare heterogeneous group of autosomal-recessive salt-losing renal tubular disorders that can present in fetal life (antenatal Bartter syndrome; ABS) as "unexplained" early-onset polyhydramnios, often associated with growth restriction. Prenatal diagnosis of the condition involves assessment of amniotic fluid biochemistry in a setting of polyuric polyhydramnios; with elevated chloride levels considered a consistent and diagnostic finding. Other amniotic fluid biochemical markers have been described, notably increased aldosterone levels, and low total protein levels. Read More

    [Pheochromocytoma and pregnancy. A case report].
    Ginecol Obstet Mex 2015 Nov;83(11):735-42
    Background: Pheochromocytoma is a tumor originating in the chromaffin cells. These tumors secrete catecholamines which act on target organs and cause hypertensive crises. They are rare during pregnancy, and a differential diagnosis must be carried out mainly with pregnancy-induced hypertension. Read More

    New Insights into the Management of Patients with Autoimmune Diseases or Inflammatory Disorders During Pregnancy.
    Scand J Immunol 2016 Sep;84(3):146-9
    Department of medical microbiology, school of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    The treatment of autoimmune diseases remains a serious problem. Current therapies can lead to adverse effects in patients. One of the most vulnerable patient groups is pregnant women. Read More

    Pulmonary hypoplasia and anasarca syndrome in Cika cattle.
    Acta Vet Scand 2016 Jun 6;58(1):36. Epub 2016 Jun 6.
    Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
    Background: Hydrops foetalis is defined as excessive fluid accumulation within the foetal extravascular compartments and body cavities. It has been described in human and veterinary medicine, but despite several descriptive studies its aetiology is still not fully clarified. Pulmonary hypoplasia and anasarca (PHA) syndrome is a rare congenital abnormality in cattle that is characterised by hydrops foetalis including extreme subcutaneous oedema (anasarca) and undeveloped or poorly formed lungs (pulmonary hypoplasia). Read More

    Is plasminogen activator inhibitor-1 a physiological bottleneck bridging major depressive disorder and cardiovascular disease?
    Acta Physiol (Oxf) 2016 Jun 1. Epub 2016 Jun 1.
    Women's Health Concerns Clinic, St. Joseph's Healthcare, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
    Major depressive disorder (MDD) is estimated to affect one in twenty people worldwide. MDD is highly comorbid with cardiovascular disease (CVD), itself one of the single largest causes of mortality worldwide. A number of pathological changes observed in MDD are believed to contribute to the development of cardiovascular disease, although no single mechanism has been identified. Read More

    Successful vaginal delivery following spontaneous adrenal haemorrhage at term.
    BMJ Case Rep 2016 May 17;2016. Epub 2016 May 17.
    University of Queensland School of Medicine, Herston, Queensland, Australia University of Queensland Centre for Clinical Research, Herston, Queensland, Australia Department of Obstetric and Internal Medicine, University of Queensland School of Medicine, Herston, Queensland, Australia.
    Spontaneous adrenal haemorrhage (SAH) is a rare event in the general population, estimated to be around 0.3-1.8%. Read More

    [Adrenocortical carcinoma and pregnancy].
    Ann Endocrinol (Paris) 2016 Jun 9;77(2):139-47. Epub 2016 May 9.
    Department of Endocrinology, Cochin University Hospital, AP-HP, French Adrenal Cancer Network COMETE-Cancer, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France; UMR 8104, institut Cochin, Paris, France.
    Adrenocortical carcinoma is a rare cancer with a poor but heterogeneous prognosis. These tumours are more frequently encountered in women, sometimes very young and may be diagnosed in women in their child bearing years or already pregnant. Several clinical data have indicated that the secretion and or proliferation of adrenocortical tumors may be affected by the hormonal context of pregnancy. Read More

    MAGE-D2 and the Regulation of Renal Salt Transporters.
    N Engl J Med 2016 May 27;374(19):1888-90. Epub 2016 Apr 27.
    From the Department of Genetics and Center for Molecular Medicine, University Medical Center Utrecht, Utrecht (N.V.A.M.K.), and the Department of Physiology and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen (R.J.B.) - both in the Netherlands.

    Organ-specific systemic lupus erythematosus activity during pregnancy is associated with adverse pregnancy outcomes.
    Clin Rheumatol 2016 Jul 11;35(7):1725-32. Epub 2016 May 11.
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
    Systemic lupus erythematosus (SLE) is a disease of reproductive-age women, and thus questions regarding how disease influences pregnancy outcomes arise. We investigated whether five specific types of SLE activity during the 6 months before conception or during pregnancy (nephritis, cytopenias, skin disease, arthritis, serositis) were associated with adverse pregnancy outcomes. We performed a retrospective cohort study of pregnancy outcomes among women with SLE at the Brigham and Women's Hospital Lupus Center. Read More

    Primary aldosteronism and pregnancy.
    Ann Endocrinol (Paris) 2016 Jun 6;77(2):148-60. Epub 2016 May 6.
    Hypertension Unit, Assistance Publique-Hôpitaux de Paris, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France. Electronic address:
    Hypertension (HT) is a complication of 8% of all pregnancies and 10% of HT cases are due to primary aldosteronism (PA). There is very little data on PA and pregnancy. Given the changes in the renin angiotensin system during pregnancy, the diagnosis of PA is difficult to establish during gestation. Read More

    Polyhydramnios, Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations.
    N Engl J Med 2016 May 27;374(19):1853-63. Epub 2016 Apr 27.
    From INSERM, Centre de Recherche des Cordeliers, Unité 1138, Centre National de la Recherche Scientifique, ERL8228 Université Pierre et Marie Curie and Université Paris-Descartes, Paris (K.L., E.S., S.D.); Institute of Human Genetics (B.B.B., A.W., B.R., J.A., G.Y.), Department of Pathology (H.G.), Cologne Center for Genomics and Center for Molecular Medicine (H.T., J.A., P.N.), Department II of Internal Medicine and Center for Molecular Medicine Cologne (M.P.B., T.B., M.M.R.), and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases and Systems Biology of Aging Cologne (T.B., M.M.R.) - all at the University of Cologne, Cologne, the Department of Cellular and Integrative Physiology, University Medical Center Hamburg, Hamburg (H.V.), University Children's Hospital, Philipps University Marburg (H.W.S.), and Kuratorium für Heimdialyse, Pediatric Kidney Center (G.K.), Marburg, the Institute of Human Genetics, University Health Services Göttingen, Göttingen (G.Y.), and the Department of General Pediatrics, University Hospital Münster, Münster (K.P.S., M. Konrad) - all in Germany; the Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center (S.-S.Y., S.-H.L.), and Institute of BioMedical Sciences, Academia Sinica (S.-S.Y.) - both in Taipei, Taiwan; the Department of Biomedical Molecular Biology, Inflammation Research Center, VIB/Ghent University, Ghent (D.P., M.J.M.B.), Unité de Recherche en Physiologie Moléculaire, University of Namur, Namur (C.D., O.B.), and the Division of Nephrology, University Children's Hospital Leuven (E.L.) - all in Belgium; the Divisions of Neonatology (K.B.) and Nephrology (M. Kömhoff), Beatrix Children's Hospital, and the Departments of Obstetrics and Gynecology (L.K.D., S.A.S.), Pathology and Medical Biology (A.T.), and Genetics (T.J.K.) - all at University Medical Center Groningen, Groningen, the Netherlands; and University Children's Hospital Graz
    Background: Three pregnancies with male offspring in one family were complicated by severe polyhydramnios and prematurity. One fetus died; the other two had transient massive salt-wasting and polyuria reminiscent of antenatal Bartter's syndrome.

    Methods: To uncover the molecular cause of this possibly X-linked disease, we performed whole-exome sequencing of DNA from two members of the index family and targeted gene analysis of other members of this family and of six additional families with affected male fetuses. Read More

    [Diagnosis and treatment of pheochromocytoma in pregnancy: a case report].
    Beijing Da Xue Xue Bao 2016 Apr;48(2):370-2
    Department of Pathology, Peking University People's Hospital, Beijing 100044, China.
    Pheochromocytoma is rare in pregn'ancy. Clinical features of a case of pheochromocytoma during pregnancy in the Peking University People's Hospital was investigated and the literature reviewed to discuss the diagnosis and treatment of this disease. The patient manifested with hypertension and proteinuria, who was easily misdiagnosed with gestational hypertension disease. Read More

    Nonylphenol-induced hyperadrenalism can be reversed/alleviated by inhibiting of 11-β hydroxysteroid dehydrogenase type 1.
    Environ Toxicol Pharmacol 2016 Jun 26;44:1-12. Epub 2016 Mar 26.
    Department of Physiology, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan, ROC; Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei 11217, Taiwan, ROC; Medical Center of Aging Research, China Medical University Hospital, Taichung 40402, Taiwan, ROC; Department of Biotechnology, Asia University, Taichung 41354, Taiwan, ROC. Electronic address:
    We previously observed that nonylphenol (NP) exposure during development resulted in increases in body weight and hyperadrenalism in adult male offspring. The mechanism of hyperadrenalism includes the primary activation of the adrenal gland and the conversion of inactive glucocorticoids to active glucocorticoids by 11β-HSD1. The inhibition of 11β-HSD1 is investigated as a new therapeutic approach. Read More

    Prognostic Factors of the Efficacy of High-dose Corticosteroid Therapy in Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome During Pregnancy: A Meta-analysis.
    Medicine (Baltimore) 2016 Mar;95(13):e3203
    From the Department of Gynecology & Obstetrics (LY, CR, SC), The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan; and West Zone (MM), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
    The aim of this study was to identify the factors which can affect the efficacy of corticosteroid (CORT) therapy in the management of hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. Research articles reporting the efficacy of CORT therapy to HELLP syndrome patients were searched in several electronic databases including EMBASE, Google Scholar, Ovid SP, PubMed, and Web of Science. Study selection was based on predefined eligibility criteria. Read More

    Activity of the Hypothalamic-Pituitary-Adrenal System in Prenatally Stressed Male Rats on the Experimental Model of Post-Traumatic Stress Disorder.
    Bull Exp Biol Med 2016 Mar 29;160(5):601-4. Epub 2016 Mar 29.
    Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
    Using the experimental model of post-traumatic stress disorder (stress-restress paradigm), we studied the dynamics of activity of the hypothalamic-pituitary-adrenal system (HPAS) in adult male rats, whose mothers were daily subjected to restraint stress on days 15-19 of pregnancy. Prenatally stressed males that were subjected to combined stress and subsequent restress exhibited not only increased sensitivity of HPAS to negative feedback signals (manifested under restress conditions), but also enhanced stress system reactivity. These changes persisted to the 30th day after restress. Read More

    Protein Restriction During the Last Third of Pregnancy Malprograms the Neuroendocrine Axes to Induce Metabolic Syndrome in Adult Male Rat Offspring.
    Endocrinology 2016 May 23;157(5):1799-812. Epub 2016 Mar 23.
    Laboratory of Secretion Cell Biology, Department of Biotechnology, Cell Biology and Genetics (J.C.deO., R.M.G., R.A.M., L.F.B., A.M., I.P.M., C.C.S.F., A.P., P.C.F.M.), State University of Maringa, Maringá, 87020-900, PR, Brazil; Department of Physiological Sciences (J.C.deO., P.C.L., E.G.deM.), Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, 20551-030, RJ, Brazil; Institute of Health Sciences (J.C.deO.), Federal University of Mato Grosso, Sinop, 78557-267, MT, Brazil; Department of Physiological Sciences (R.M.G., R.T.), State University of Maringa, Maringá, 87020-900, PR, Brazil; Molecular Signaling Section, Laboratory of Bioorganic Chemistry (L.F.B.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892; and Department of Morphological Sciences (M.R.M.N.), State University of Maringa, Maringá, 87020-900, PR, Brazil.
    Metabolic malprogramming has been associated with low birth weight; however, the interplay between insulin secretion disruption and adrenal function upon lipid metabolism is unclear in adult offspring from protein-malnourished mothers during the last third of gestation. Thus, we aimed to study the effects of a maternal low-protein diet during the last third of pregnancy on adult offspring metabolism, including pancreatic islet function and morphophysiological aspects of the liver, adrenal gland, white adipose tissue, and pancreas. Virgin female Wistar rats (age 70 d) were mated and fed a protein-restricted diet (4%, intrauterine protein restricted [IUPR]) from day 14 of pregnancy until delivery, whereas control dams were fed a 20. Read More

    Renal tubular acidosis type 4 in pregnancy.
    BMJ Case Rep 2016 Mar 17;2016. Epub 2016 Mar 17.
    Women's Directorate Office, Guy's and St Thomas' NHS Foundation Trust, London, UK.
    We describe the clinical course of renal tubular acidosis (RTA) type 4 in pregnancy, which has not been previously published. Renal tubular acidosis type 4 is a condition associated with increased urinary ammonia secondary to hypoaldosteronism or pseudohypoaldosteronism. Pregnancy may worsen the hyperkalaemia and acidosis of renal tubular acidosis type 4, possibly through an antialdosterone effect. Read More

    Clinical Spectrum of Disorders of Sexual Differentiation.
    J Coll Physicians Surg Pak 2016 Mar;26(3):199-203
    Medical Unit II, Jinnah Postgraduate Medical Centre (JPMC), Karachi.
    Objective: To describe the mode of presentation and causes of the disorders of sexual differentiation in patients presenting in the Endocrine Clinic.

    Study Design: Observational study.

    Place And Duration Of Study: The Endocrine and Diabetes Unit of Jinnah Postgraduate Medical Centre (JPMC), Karachi, from July 2012 to July 2014. Read More

    Gastroschisis in a fetus with a congenital neuroblastoma: Association or coincidence?
    Birth Defects Res A Clin Mol Teratol 2016 Mar 15;106(3):208-12. Epub 2016 Feb 15.
    Clinical Genetics, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA) and Complexo Hospitalar Santa Casa de Porto Alegre (CHSCPA), RS, Brazil.
    Background: Gastroschisis is the most common abdominal wall defect. It is characterized by herniation of the intestine and other abdominal organs through a defect in the abdominal wall. Neuroblastoma is the most common malignant tumor observed during the neonatal period. Read More

    Sperm retrieval and concomitant tumor resection in azoospermic men with congenital adrenal hyperplasia and bilateral testicular adrenal rest tumors: a case report.
    J Assist Reprod Genet 2016 Apr 9;33(4):545-8. Epub 2016 Feb 9.
    Austin Fertility & Reproductive Medicine/Westlake IVF, 300 Beardsley Lane, Building B, Suite 200, Austin, TX, 78746, USA.
    Purpose: The objective of this study was to offer a new treatment approach for sperm retrieval simultaneously with tumor resection in azoospermic men with congenital adrenal hyperplasia (CAH), orchialgia, and bilateral testicular adrenal rest tumors (TARTs) who fail to respond to medical treatment.

    Methods: This is a retrospective chart review from a couple's fertility center.

    Results: Between May 2013 and May 2015, two azoospermic men with CAH and bilateral TARTs, with orchialgia, and desire to conceive underwent bilateral TART resection in the same surgical setting as sperm retrieval after remaining azoospermic with normalization of gonadotropins with treatment with human chorionic gonadotropin (hCG). Read More

    Neonatal proinflammatory challenge in male Wistar rats: Effects on behavior, synaptic plasticity, and adrenocortical stress response.
    Behav Brain Res 2016 May 3;304:1-10. Epub 2016 Feb 3.
    Department of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow 117485, Russia. Electronic address:
    Effects of neonatal proinflammatory stress (NPS) on the development of anxiety and depressive-like behavior, stress responsiveness, hippocampal plasticity and conditioned fear response were studied in adolescent and adult male Wistar rats. On PND 3 and PND 5, the pups were subcutaneously injected with bacterial lipopolysaccharide (LPS, 50 μg/kg). In the open field test, signs of increased anxiety were demonstrated in adolescent (PND 32), but not in adult (PND 101) rats. Read More

    The Effects of Electromagnetic Field on the Endocrine System in Children and Adolescents.
    Pediatr Endocrinol Rev 2015 Dec;13(2):531-45
    Children are exposed to various kind of non-ionizan radiation in their daily life involuntarily. The potential sensitivity of developing organism to the effects of radiofrequency (RF) signals, the higher estimated specific absorption rate (SAR) values of children and greater lifetime cumulative risk raised the scientific interest for children's vulnerability to electromagnetic fields (EMFs). In modern societies, children are being exposed to EMFs in very early ages. Read More

    [Sheehan's syndrome--a forgotten disease with 100 years' history].
    Przegl Lek 2015 ;72(6):313-20
    Although named after Harold Sheehan, postpartum ischemic pituitary necrosis was reported for the first time 100 years ago in Przeglad Lekarski by Leon Konrad Gliński. In the majority of cases, the syndrome is a consequence of severe postpartum bleeding episode resulting in severe hypotension or hemorrhagic shock. The frequency of Sheehan's syndrome has decreased in developed countries as a result of improved obstetrical care, but this clinical entity remains a common cause of hypopituitarism in developing countries. Read More

    Management of rhinosinusitis during pregnancy: systematic review and expert panel recommendations.
    Rhinology 2016 Jun;54(2):99-104
    Royal National Throat, Nose and Ear Hospital, University College London Hospitals, London, United Kingdom.
    Background: Management of rhinosinusitis during pregnancy requires special considerations.

    Objectives: 1. Conduct a systematic literature review for acute and chronic rhinosinusitis (CRS) management during pregnancy. Read More

    Post-partum hypoglycemia and hypothermia as first manifestations of lymphocytic adenohypophysitis: A case report.
    J Obstet Gynaecol Res 2016 Apr 19;42(4):467-70. Epub 2016 Jan 19.
    Department of Obstetrics and Gynecology, Osaka Rosai Hospital, Sakai, Japan.
    Lymphocytic adenohypophysitis is a very rare autoimmune disease characterized by an anterior pituitary infiltration of lymphocytes that cause various symptoms, such as headache, visual disturbance, and hypopituitarism. Lymphocytic adenohypophysitis is more common in women and has a remarkable association with the perinatal period. Recently, we experienced a case of lymphocytic adenohypophysitis shortly after delivery. Read More

    Late-Pregnancy Salivary Cortisol Concentrations of Ghanaian Women Participating in a Randomized Controlled Trial of Prenatal Lipid-Based Nutrient Supplements.
    J Nutr 2016 Feb 13;146(2):343-52. Epub 2016 Jan 13.
    Departments of Nutrition and.
    Background: High circulating cortisol is associated with miscarriage, preterm birth, and low birth weight. Research in nonpregnant individuals suggests that improved nutrition may lower cortisol concentrations. It is unknown whether nutritional supplementation during pregnancy lowers cortisol. Read More

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