4,212 results match your criteria Adrenal Disease and Pregnancy


Gestational Stress Augments Postpartum β-Amyloid Pathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease.

Cereb Cortex 2018 Oct 1. Epub 2018 Oct 1.

Department of Neuroscience, Canadian Centre for Behavioural Neuroscience (CCBN), University of Lethbridge, Lethbridge, AB, Canada.

Besides well-known risk factors for Alzheimer's disease (AD), stress, and in particular noise stress (NS), is a lifestyle risk factor common today. It is known that females are at a significantly greater risk of developing AD than males, and given that stress is a common adversity in females during pregnancy, we hypothesized that gestational noise exposure could exacerbate the postpartum development of the AD-like neuropathological changes during the life span. Pregnant APPNL-G-F/NL-G-F mice were randomly assigned to either the stress condition or control group. Read More

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http://dx.doi.org/10.1093/cercor/bhy251DOI Listing
October 2018

Primary hypophysitis and other autoimmune disorders of the sellar and suprasellar regions.

Rev Endocr Metab Disord 2018 Dec 13. Epub 2018 Dec 13.

Medicover GmbH, Berlin/Hannover, Germany.

The pituitary gland and the hypothalamus can be affected by autoimmune-mediated structural and functional disruption. These autoimmune-mediated diseases occur more commonly in females and are often found during pregnancy or in the post-partum period. Autoimmune diseases can either affect parts of the pituitary or hypothalamus, or can involve both sellar and suprasellar structures. Read More

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http://link.springer.com/10.1007/s11154-018-9480-1
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http://dx.doi.org/10.1007/s11154-018-9480-1DOI Listing
December 2018
4 Reads

Against the Odds.

Authors:
Emily M Bucholz

JAMA 2018 Dec;320(22):2313-2314

Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jama.2018.17821DOI Listing
December 2018

Surgery for Cushing's disease in pregnancy: our experience and a literature review.

Ann R Coll Surg Engl 2019 Jan 5;101(1):e26-e31. Epub 2018 Oct 5.

Department of Endocrinology, University Hospital Birmingham , Birmingham , UK.

Cushing's syndrome in pregnancy is a rare phenomenon and there is limited literature on its management. Cushing's disease in pregnancy is even less common and there is little guidance to help in the treatment for this patient group. Diagnosis of Cushing's syndrome in pregnancy is often delayed due to overlap of symptoms. Read More

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http://dx.doi.org/10.1308/rcsann.2018.0175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303815PMC
January 2019
10 Reads

Gestational chronodisruption leads to persistent changes in the rat fetal and adult adrenal clock and function.

J Physiol 2018 Dec 17;596(23):5839-5857. Epub 2018 Sep 17.

Laboratorio de Cronobiología del Desarrollo, Instituto de Anatomía, Histología y Patología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile.

Key Points: Light at night is essential to a 24/7 society, but it has negative consequences on health. Basically, light at night induces an alteration of our biological clocks, known as chronodisruption, with effects even when this occurs during pregnancy. Here we explored the developmental impact of gestational chronodisruption (chronic photoperiod shift, CPS) on adult and fetal adrenal biorhythms and function. Read More

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http://dx.doi.org/10.1113/JP276083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265531PMC
December 2018
7 Reads
5.040 Impact Factor

Successful Management of Pheochromocytoma Detected in Pregnancy by Interval Adrenalectomy in a VHL Patient.

Case Rep Endocrinol 2018 19;2018:9014585. Epub 2018 Jul 19.

Colombo South Teaching Hospital, Kalubowila, Sri Lanka.

A 34-year-old mother with diabetes mellitus for 6 years presented in the late second trimester of her third pregnancy with new onset hypertension and characteristic hyperadrenergic spells. Clinical examination was unremarkable except a blood pressure of 170/110 mmhg. She had an elevated 24 hour urinary normetanephrine level with ultrasonic evidence of a hyperechoic hypervascular well-defined right supra renal mass of 6 x 5 cm in size which was very suggestive of a pheochromocytoma. Read More

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http://dx.doi.org/10.1155/2018/9014585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076903PMC
July 2018
3 Reads

Programming Bugs: Microbiota and the Developmental Origins of Brain Health and Disease.

Biol Psychiatry 2019 Jan 27;85(2):150-163. Epub 2018 Jun 27.

APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland. Electronic address:

It has been nearly 30 years since Dr. David Barker first highlighted the importance of prenatal factors in contributing to the developmental origins of adult disease. This concept was later broadened to include postnatal events. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.06.014DOI Listing
January 2019
12 Reads

Developmental origins of the human hypothalamic-pituitary-adrenal axis.

Expert Rev Endocrinol Metab 2017 09 2;12(5):321-339. Epub 2017 Aug 2.

a Department of Psychiatry and Human Behavior , University of California , Irvine , CA , USA.

Introduction: The developmental origins of disease or fetal programming model predicts that intrauterine exposures have life long consequences for physical and psychological health. Prenatal programming of the fetal hypothalamic-pituitary-adrenal (HPA) axis is proposed as a primary mechanism by which early experiences are linked to later disease risk. Areas covered: This review describes the development of the fetal HPA axis, which is determined by an intricately timed cascade of endocrine events during gestation and is regulated by an integrated maternal-placental-fetal steroidogenic unit. Read More

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http://dx.doi.org/10.1080/17446651.2017.1356222DOI Listing
September 2017
2 Reads

[A case of pheochromocytoma discovered during a twin pregnancy: a diagnosis not to be misunderstood and literature review].

Pan Afr Med J 2018 23;29:168. Epub 2018 Mar 23.

Service d'Endocrinologie, Diabétologie et Maladies Métaboliques, Hôpital Arrazi, CHU Mohammed VI, Laboratoire de Recherche de Pneumo-Cardio-Immunopathologie et Métabolisme (PCIM), Faculté de Médecine et de Pharmacie de Marrakech, Université Cadi Ayad, Marrakech, Maroc.

The pheochromocytoma is a rare, but potentially serious, which can be revealed by pregnancy. Less than 250 cases described in the literature .The rarity of this association and similarity with pregnancy-induced hypertension explains the frequency of unknown diagnoses during pregnancy. Read More

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http://dx.doi.org/10.11604/pamj.2018.29.168.13901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057585PMC
August 2018
3 Reads

Dehydroepiandrosterone Research: Past, Current, and Future.

Vitam Horm 2018 16;108:1-28. Epub 2018 Mar 16.

Department of Biochemistry and Molecular Genetics, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY, United States. Electronic address:

The discovery of "oestrus-producing" hormones was a major research breakthrough in biochemistry and pharmacology during the early part of the 20th century. The elucidation of the molecular weight and chemical structure of major oxidative metabolites of dehydroepiandrosterone (DHEA) led to the award of the Nobel Prize in 1939 to Adolf Frederick Johann Butenandt and Leopold Ruzicka. Considered a bulk androgen in the circulation, DHEA and its sulfated metabolite DHEA-S can be taken up by most tissues where the sterols are metabolized to active androgenic and estrogenic compounds needed for growth and development. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00836729183003
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http://dx.doi.org/10.1016/bs.vh.2018.02.002DOI Listing
November 2018
32 Reads

Clinical and Etiological Aspects of Gynecomastia in Adult Males: A Multicenter Study.

Biomed Res Int 2018 29;2018:8364824. Epub 2018 May 29.

Servicio de Endocrinología, Metabolismo y Medicina Nuclear, Hospital Italiano, Buenos Aires, Argentina.

Objectives: To evaluate the characteristics of presentation, biochemical profile, and etiology of gynecomastia in adults.

Methods: Medical records of 237 men aged 18-85 years with gynecomastia were evaluated.

Results: Highest prevalence of gynecomastia was observed between 21 and 30 years (n = 74; 31. Read More

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http://dx.doi.org/10.1155/2018/8364824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996435PMC
January 2019
26 Reads

Pheochromocytoma and Paraganglioma in Neurofibromatosis type 1: frequent surgeries and cardiovascular crises indicate the need for screening.

Clin Diabetes Endocrinol 2018 22;4:15. Epub 2018 Jun 22.

2Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan Health System, Medical Science Research Building II, Office # 2560e, 1150 West Medical Center Drive, Ann Arbor, MI 48109 USA.

Background: Pheochromocytomas and Paragangliomas (PCC/PGL) are rare endocrine tumors that are mostly benign, but often hormone producing, causing significant morbidity and mortality due to excess catecholamine secretion and cardiovascular crises. It is estimated that 30% of PCC/PGL are due to germline mutations, including Neurofibromatosis type 1 (). There is little published data describing the phenotype of NF1-associated PCC/PGL and there are no established recommendations for PCC/PGL screening in NF1. Read More

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http://dx.doi.org/10.1186/s40842-018-0065-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013983PMC
June 2018
5 Reads

Syncope caused by complete heart block and ventricular arrhythmia as early manifestation of systemic lupus erythematosus in a pregnant patient: a case report.

Lupus 2018 Sep 28;27(10):1729-1731. Epub 2018 Jun 28.

1 Division of Cardiology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung City, Taiwan.

Systemic lupus erythematosus (SLE) can affect all heart structures including the conduction system, with either reversible or permanent derangement. However, only a few cases of adult SLE and complete atrioventricular (AV) block have been reported. We describe a young pregnant woman who initially presented with complete AV block on electrocardiography before the diagnosis of SLE. Read More

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http://dx.doi.org/10.1177/0961203318782425DOI Listing
September 2018
1 Read

Trelegy Ellipta--a three-drug inhaler for COPD.

Authors:

Med Lett Drugs Ther 2018 05;60(1547):86-88

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May 2018
10 Reads

Early-Life Stress: From Neuroendocrine Mechanisms to Stress-Related Disorders.

Horm Res Paediatr 2018 8;89(5):372-379. Epub 2018 Jun 8.

Stress exposure is highly prevalent in the general population; however, the experience of stress during vulnerable periods of development has substantial and permanent effects on brain structure and function and physical health in adulthood. Stress, the state of threatened homeostasis, is generally associated with a time-limited activation of the stress system, i.e. Read More

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http://dx.doi.org/10.1159/000488468DOI Listing
October 2018
11 Reads

An Ω-3 fatty acid-deficient diet during gestation induces depressive-like behavior in rats: the role of the hypothalamo-pituitary-adrenal (HPA) system.

Food Funct 2018 Jun;9(6):3481-3488

Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China.

Low intake of omega-3 (Ω-3) polyunsaturated fatty acids (PUFAs) especially docosahexaenoic acid (DHA) is associated with postpartum depression. DHA deficiency is accompanied by impaired attention and cognition, and will precipitate psychiatric symptoms. However, the effects of dietary DHA on postpartum depression remain unclear. Read More

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http://dx.doi.org/10.1039/c7fo01714fDOI Listing
June 2018
6 Reads

Long QT syndrome KCNH2 mutation with sequential fetal and maternal sudden death.

Forensic Sci Med Pathol 2018 09 8;14(3):367-371. Epub 2018 Jun 8.

Section of Forensic Pediatric Medicine, Clinic of Laboratory Medicine, Oslo University Hospital, Oslo, Norway.

We report a case of a woman who experienced intrauterine fetal death at full term pregnancy, and then died suddenly soon after learning about the death of her fetus. At autopsy, previously undiagnosed neurofibromatosis and an adrenal gland pheochromocytoma were discovered in the mother. Genetic screening also revealed a novel KCNH2mutation in both fetus and mother indicating type 2 congenital long-QT syndrome (LQTS). Read More

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http://dx.doi.org/10.1007/s12024-018-9989-3DOI Listing
September 2018
2 Reads

The Hypothalamic-Pituitary-Adrenal Axis and the Fetus.

Horm Res Paediatr 2018 6;89(5):380-387. Epub 2018 Jun 6.

Division of Pediatric Endocrinology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Glucocorticoids (GCs), cortisol in humans, influence multiple essential maturational events during gestation. In the human fetus, fetal hypothalamic-pituitary-adrenal (HPA) axis function, fetal adrenal steroidogenesis, placental 11β- hydroxysteroid dehydrogenase type 2 activity, maternal cortisol concentrations, and environmental factors impact fetal cortisol exposure. The beneficial effects of synthetic glucocorticoids (sGCs), such as dexamethasone and betamethasone, on fetal lung maturation have significantly shifted the management of preterm labor and threatened preterm birth. Read More

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http://dx.doi.org/10.1159/000488106DOI Listing
October 2018
2 Reads

Hyperkalaemic periodic paralysis in pregnancy.

BMJ Case Rep 2018 Jun 4;2018. Epub 2018 Jun 4.

Department of Obstetrics and Gynaecology, Sarikei Hospital, Sarikei, Sarawak, Malaysia.

Hyperkalaemic periodic paralysis is a rare skeletal muscle disorder which is characterised by episodic muscle paralysis associated with hyperkalaemia. Although it is an autosomal-dominant disease, cases of de novo mutations have been reported. We report the case of a 30-year-old woman, gravida 5 para 3+1, who was planned for an elective repeated caesarean section at 38 weeks and 3 days of pregnancy. Read More

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http://dx.doi.org/10.1136/bcr-2017-223588DOI Listing
June 2018
14 Reads

Maternal hypothalamus-pituitary-adrenal (HPA) system activity and stress during pregnancy: Effects on gestational age and infant's anthropometric measures at birth.

Psychoneuroendocrinology 2018 Aug 22;94:152-161. Epub 2018 Apr 22.

Department of Psychiatry and Psychotherapy, RG Stress, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.

Background: Prenatal maternal stress might be a risk for the developing fetus and may have long-lasting effects on child and adult vulnerability to somatic and psychiatric disease. Over-exposure of the unborn to excess glucocorticoids and subsequent alteration of fetal development is hypothesized to be one of the key mechanisms linking prenatal stress with negative child outcome.

Methods: In this prospective longitudinal study, mothers-to-be (n = 405) in late pregnancy (36. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2018.04.022DOI Listing
August 2018
3 Reads

Urticarial Lesions in a Pregnant Woman.

Acta Dermatovenerol Croat 2018 Apr;26(1):71-72

Sergio Santos-Alarcon, MD, Department of Dermatology, , Hospital Universitario Doctor Peset, Avinguda Gaspar Aguilar Nº 90, 4601 Valencia, Spain;

Dear Editor, Gestational pemphigoid (GP) is a rare autoimmune bullous dermatosis in pregnancy. GP usually occurs during the second or third month of pregnancy. It clinically manifests as the development of either early-onset urticarial lesions or late-onset subepidermal blisters that may linger for weeks or even months. Read More

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April 2018
6 Reads

Validation of an Expanded Carrier Screen that Optimizes Sensitivity via Full-Exon Sequencing and Panel-wide Copy Number Variant Identification.

Clin Chem 2018 Jul 14;64(7):1063-1073. Epub 2018 May 14.

Counsyl, Inc., South San Francisco, CA.

Background: By identifying pathogenic variants across hundreds of genes, expanded carrier screening (ECS) enables prospective parents to assess the risk of transmitting an autosomal recessive or X-linked condition. Detection of at-risk couples depends on the number of conditions tested, the prevalence of the respective diseases, and the screen's analytical sensitivity for identifying disease-causing variants. Disease-level analytical sensitivity is often <100% in ECS tests because copy number variants (CNVs) are typically not interrogated because of their technical complexity. Read More

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http://dx.doi.org/10.1373/clinchem.2018.286823DOI Listing
July 2018
3 Reads

Prenatal Treatment of Congenital Adrenal Hyperplasia: Long-Term Effects of Excess Glucocorticoid Exposure.

Horm Res Paediatr 2018 9;89(5):362-371. Epub 2018 May 9.

Prenatal treatment of congenital adrenal hyperplasia with dexamethasone (DEX) has been in use since the mid-1980s and has proven effective at reducing virilization of external genitalia in affected girls. However, multiple experimental studies on animals and clinical studies on humans show that prenatal administration of glucocorticoids may cause unwanted adverse effects which have raised concerns about the long-term safety of the treatment. The long-term outcome of prenatal DEX treatment on cognition has been investigated, but the results are still conflicting. Read More

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http://dx.doi.org/10.1159/000485100DOI Listing
October 2018
3 Reads

Gestational Hypoxia and Developmental Plasticity.

Physiol Rev 2018 07;98(3):1241-1334

The Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine , Loma Linda, California.

Hypoxia is one of the most common and severe challenges to the maintenance of homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is multidimensional involving complicated intracellular networks concerned with the transduction of hypoxia-induced responses. Of all the stresses to which the fetus and newborn infant are subjected, perhaps the most important and clinically relevant is that of hypoxia. Read More

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http://dx.doi.org/10.1152/physrev.00043.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088145PMC

A Novel Mutation c.153 C>A in a Tunisian Girl With Wolman Disease and Unusual Presentation: Hemophagocytic Lymphohistiocytosis.

J Pediatr Hematol Oncol 2018 Apr 26. Epub 2018 Apr 26.

Departments of Pediatrics B.

Wolman disease is an ultrarare lysosomal storage disease caused by a mutation in the LIPA gene. The clinical features of Wolman disease include early onset of vomiting, diarrhea, failure to thrive, hepatosplenomegaly, and bilateral adrenal calcification. We report the case of a 3-month-old infant who presented clinical features of hemophagocytic lymphohistiocytosis. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001192DOI Listing
April 2018
7 Reads

Treatment of Addison's disease during pregnancy.

Endocrinol Diabetes Metab Case Rep 2018 12;2018. Epub 2018 Apr 12.

Endocrinology, Diabetes and Metabolism Department, Coimbra Hospital and University Center, Coimbra, Portugal.

Addison's disease, or primary adrenocortical insufficiency, is a long-term, potentially severe, rare endocrine disorder. In pregnancy, it is even rarer. We report the case of a 30-year-old pregnant patient with Addison's disease, referred to Obstetrics-Endocrinology specialty consult at 14 weeks gestation. Read More

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http://dx.doi.org/10.1530/EDM-17-0179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900459PMC
April 2018
3 Reads

MANAGEMENT OF ENDOCRINE DISEASE: Management of Cushing's syndrome during pregnancy: solved and unsolved questions.

Eur J Endocrinol 2018 Jun 9;178(6):R259-R266. Epub 2018 Mar 9.

Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale (INSERM), U1251, Marseille Medical Genetics, Marseille, France.

With fewer than 200 reported cases, Cushing's syndrome (CS) in pregnancy remains a diagnostic and therapeutic challenge. In normal pregnancies, misleading signs may be observed such as striae or hypokalemia, while plasma cortisol and urinary free cortisol may rise up to 2- to 3-fold. While the dexamethasone suppression test is difficult to use, reference values for salivary cortisol appear valid. Read More

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http://dx.doi.org/10.1530/EJE-17-1058DOI Listing
June 2018
15 Reads

Pyoderma Gangrenosum of the Scalp: A Rare Clinical Variant.

Wounds 2018 Feb;30(2):E16-E20

Oregon Health & Sciences University, Department of Dermatology, Portland, OR.

Pyoderma gangrenosum (PG) is a rare, neutrophil-predominant dermatosis that usually presents as a papule or pustule and progresses into a painful ulcer. Clinical and histopathological features are nonspecific, making PG a challenging condition to diagnose. Lesions may occur anywhere on the body; however, the lower extremity is the most common location. Read More

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February 2018
8 Reads

Acute pituitary disease in pregnancy: how to handle hypophysitis and Sheehan's syndrome.

Minerva Endocrinol 2018 Dec 19;43(4):465-475. Epub 2018 Feb 19.

Department of Neurosurgery, University of Tübingen, Tübingen, Germany.

Pregnancy-related hypophysitis (PR-Hy) that typically occurs during late pregnancy and the early postpartum period is considered an autoimmune disorder. Knowledge and awareness of characteristic clinical symptoms and specific endocrine and neuroradiological features mostly enables a correct diagnosis and guarantees best possible management. In the presence of mild clinical symptoms, a "wait-and-watch" approach is recommended. Read More

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http://dx.doi.org/10.23736/S0391-1977.18.02814-6DOI Listing
December 2018
1 Read

Cushing's disease: major difficulties in diagnosis and management during pregnancy.

Minerva Endocrinol 2018 Dec 13;43(4):435-445. Epub 2018 Feb 13.

Department of Endocrinology, Sant Pau Hospital, Barcelona, Spain -

Pregnancy in women with a diagnosis of Cushing' syndrome (CS) is an extremely rare event and its diagnosis and treatment are a real medical challenge. During pregnancy, the hypothalamus-pituitary-adrenal axis undergoes major changes leading to a significant increase in plasma cortisol levels throughout gestation. The difficulties in diagnosis are related to the resemblance of symptoms of CS and those of pregnancy, and to the complex interpretation of the screening tests. Read More

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http://dx.doi.org/10.23736/S0391-1977.18.02803-1DOI Listing
December 2018
3 Reads
1.320 Impact Factor

A rare presentation of pheochromocytoma in pregnancy: a case report.

J Med Case Rep 2018 Feb 9;12(1):37. Epub 2018 Feb 9.

Obstetrics and Gynecology Department, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Early diagnosis of pheochromocytoma and its proper management can lessen its mortality and morbidity. This case report describes a 24-year-old pregnant woman with an unusual presentation of pheochromocytoma.

Case Presentation: An Iranian 24-year-old primigravid woman from Kordistan province was referred to our center with left flank pain at 37 weeks of gestation. Read More

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http://dx.doi.org/10.1186/s13256-017-1549-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806440PMC
February 2018
5 Reads

Laparoscopic approach to pheochromocytoma in pregnancy: case report.

Int Braz J Urol 2018 May-Jun;44(3):629-633

Hospital Regional do Câncer de Presidente Prudente, Presidente Prudente, SP, Brasil.

A 32-year-old 22-week pregnant hypertensive woman with sporadic episodes of headaches, sweating, and facial flushing was diagnosed with pheochromocytoma through biochemical and imaging tests. Perioperative management included a multidisciplinary approach, symptom stabilization with ɑ blockade followed by β blockade, and tumor resection by laparoscopic adrenalectomy at 24 weeks gestation. The diagnosis was confirmed by histopathological examination and immunohistochemistry tests. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2017.0540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996791PMC
July 2018
3 Reads

A human exposure based mixture of persistent organic pollutants affects the stress response in female mice and their offspring.

Chemosphere 2018 Apr 18;197:585-593. Epub 2018 Jan 18.

Section for Experimental Biomedicine, Department of Production Animal Clinical Sciences, Norwegian University of Life Sciences, Norway.

Persistent organic pollutants (POPs) are found in the food chain of both humans and animals and exert a wide spectrum of potentially adverse effects. The present experiment aimed to investigate whether a defined mixture of 29 POPs, based on the dietary intake of Scandinavians, could affect the stress response in female mice exposed through ingestion, and in their offspring. Female mice 129:C57BL/6F0 hybrids were exposed from weaning, throughout pregnancy, and up until necropsy, to either 5000 × or 100 000 × the estimated daily intake for Scandinavians. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.01.085DOI Listing
April 2018
5 Reads

Prenatal testosterone and theory of mind development: Findings from disorders of sex development.

Psychoneuroendocrinology 2018 03 14;89:250-255. Epub 2017 Dec 14.

Department of Medical Psychology (Gender and Sexology), VU University Medical Center, Amsterdam, The Netherlands; Department of Plastic, Reconstructive and Hand Surgery, VU University Medical Center, Amsterdam, The Netherlands.

Women on average perform better than men on the "Reading the Mind in the Eyes" test (RMET) which is a measure of Theory of Mind (ToM). The aim of this study was to assess whether these sex differences are influenced by differences in prenatal testosterone levels through a study on individuals with Disorders of Sex Development and matched controls. ToM performance was examined using the RMET in female-assigned-at-birth individuals with increased prenatal testosterone exposure (Congenital Adrenal Hyperplasia (CAH) and 5-alpha Reductase type-2 Deficiency (5α-RD-2)), female-assigned-at-birth individuals with testosterone insensitivity (Complete Androgen Insensitivity Syndrome (CAIS)), and their age-matched unaffected male and female relatives. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064530173126
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http://dx.doi.org/10.1016/j.psyneuen.2017.12.008DOI Listing
March 2018
5 Reads

Postpartum depression and vitamin D: A systematic review.

Crit Rev Food Sci Nutr 2018 Feb 2:1-7. Epub 2018 Feb 2.

c Food Security Research Center, Isfahan University of Medical Sciences , Isfahan , Iran.

Postpartum depression (PPD) is a prevalent mood disorder estimated to affect 20%-40% of women worldwide after childbirth. In recent studies, the effect of vitamin D on prevention of mood disorders and depression has been investigated, but it is still unclear how vitamin D may affect PPD. The evidence on the relevance between vitamin D deficiency and PPD is inconsistent, and assessment of the recent literature has not previously been carried out. Read More

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http://dx.doi.org/10.1080/10408398.2017.1423276DOI Listing
February 2018
6 Reads

IGF1/MAPK/ERK signaling pathway-mediated programming alterations of adrenal cortex cell proliferation by prenatal caffeine exposure in male offspring rats.

Toxicol Appl Pharmacol 2018 02 16;341:64-76. Epub 2018 Jan 16.

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address:

Our previous study proposed a glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming mechanism for prenatal caffeine exposure (PCE)-induced adrenal developmental dysfunction. Here, we focused on PCE-induced cell proliferation changes of the adrenal cortex in male offspring rats before and after birth and clarified the intrauterine programming mechanism. On gestational day (GD) 20, the PCE group had an elevated serum corticosterone level reduced fetal bodyweight, maximum adrenal sectional area, and elevated adrenal corticosterone and aldosterone contents. Read More

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http://dx.doi.org/10.1016/j.taap.2018.01.008DOI Listing
February 2018
8 Reads

Osmotic Demyelination Unrelated to Hyponatremia.

Am J Kidney Dis 2018 Mar 23;71(3):436-440. Epub 2017 Dec 23.

Division of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, TX; Division of Nephrology, Department of Medicine, Methodist Hospital, Houston, TX; Renal Section, Veterans Affairs Medical Center, Houston, TX.

Osmotic demyelination unrelated to hyponatremia is rarely reported. We present a case of osmotic demyelination in a patient with hypernatremia in the absence of preceding hyponatremia and review previously reported cases of osmotic demyelination in nonhyponatremic patients. We conclude that a rapid increase in serum sodium concentration and plasma tonicity even in the absence of preceding hyponatremia may surpass the brain's capacity for adaptation to hypertonicity and lead to osmotic demyelination in predisposed individuals. Read More

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http://dx.doi.org/10.1053/j.ajkd.2017.10.010DOI Listing
March 2018
16 Reads

A rare cause of neonatal persistent jaundice.

BMJ Case Rep 2017 Dec 22;2017. Epub 2017 Dec 22.

Department of Paediatric Endocrinology, Diabetes and Growth, Hospital Pediátrico de Coimbra, Coimbra, Portugal.

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http://dx.doi.org/10.1136/bcr-2017-223306DOI Listing
December 2017
7 Reads

Fetal adrenal gland enlargement - prenatal and postnatal management.

Neuro Endocrinol Lett 2017 Nov;38(Suppl1):31-34

St. Elisabeth University of Health and Social Sciences, Bratislava, Slovakia.

Background: The enlargement of suprarenal gland is related to preterm birth and the birth weight. The ultrasound measurement of fetal adrenal gland volume may identify women at risk for impending preterm birth. The aim of our study was to investigate the newborns in the region of western Slovakia followed up due to suprarenal gland enlargement. Read More

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November 2017
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Co-culture of H295R Adrenocortical Carcinoma and BeWo Choriocarcinoma Cells to Study Feto-placental Interactions: Focus on Estrogen Biosynthesis.

Methods Mol Biol 2018 ;1710:295-304

INRS - Institut Armand-Frappier, 531, Boulevard des Prairies, Laval, QC, Canada, H7V 1B7.

Estrogens are produced in large amounts during pregnancy, as a result of a tightly regulated cooperation between the maternal and fetal adrenal cortex, which produce androgen precursors, and the placental villous trophoblast, which transforms these precursors into estrogens. These estrogens play an important role in proper placental function, in adaptation of the mother to pregnancy, as well as in adequate fetal development. Disruption of estrogen production is associated with poor pregnancy outcomes and fetal malformation or altered fetal programming. Read More

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http://dx.doi.org/10.1007/978-1-4939-7498-6_23DOI Listing
July 2018
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MANAGEMENT OF ENDOCRINE DISEASE: Fertility, pregnancy and lactation in women with adrenal insufficiency.

Eur J Endocrinol 2018 Feb 30;178(2):R45-R53. Epub 2017 Nov 30.

Klinik für EndokrinologieDiabetologie und Klinische Ernährung, UniversitätsSpital Zürich, Zürich, Switzerland

With the introduction of hormonal substitution therapy in the 1950s, adrenal insufficiency (AI) has been turned into a manageable disease in pregnant women. In fact, in the light of glucocorticoid replacement therapy and improved obstetric care, it is realistic to expect good maternal and fetal outcomes in patients with AI. However, there are still a number of challenges such as establishing the diagnosis of AI in pregnant women and optimizing the treatment of AI and related comorbidities prior to as well as during pregnancy. Read More

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http://dx.doi.org/10.1530/EJE-17-0975DOI Listing
February 2018
22 Reads

A Case of Cushing's Syndrome in Pregnancy.

Iran J Med Sci 2017 Nov;42(6):607-610

Department of Obstetrics and Gynecology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Cushing's syndrome (CS) occurs rarely during pregnancy. CS can be caused by prolonged abnormal exposure to excess glucocorticoids leading to special and significant signs and symptoms. It is often difficult to diagnose pathological hypercortisolism in pregnant women since some symptoms of the disease might be due to a complicated pregnancy, including preeclampsia or gestational diabetes. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684384PMC
November 2017
7 Reads

Effects and Interactions of Prenatal Ethanol Exposure, a Post-Weaning High-Fat Diet and Gender on Adult Hypercholesterolemia Occurrence in Offspring Rats.

Cell Physiol Biochem 2017 23;44(2):657-670. Epub 2017 Nov 23.

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, China.

Background/aims: Prenatal ethanol exposure (PEE) could induce intrauterine programming of hypothalamic-pituitary-adrenal axis-associated neuroendocrine metabolism, resulting in intrauterine growth retardation and susceptibility to adult hypercholesterolemia in offspring. This study aimed to analyse the effects and interactions of PEE, a post-weaning high-fat diet (HFD) and gender on the occurrence of adult hypercholesterolemia in offspring rats.

Methods: Wistar female rats were treated with ethanol (4 g/kg. Read More

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http://dx.doi.org/10.1159/000485277DOI Listing
January 2018
8 Reads

Antenatal Bartter syndrome presenting with vomiting and constipation mimicking subacute intestinal obstruction in a 20-day-old neonate.

BMJ Case Rep 2017 Nov 14;2017. Epub 2017 Nov 14.

Hamad Medical Corporation, Doha, Qatar.

Antenatal Bartter syndrome is a rare condition that can present with different clinical features. These features include early onset maternal polyhydramnios, failure to thrive, prematurity and nephrocalcinosis.We are presenting this 20-day-old girl who had an antenatal history of polyhydramnios. Read More

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http://dx.doi.org/10.1136/bcr-2017-221062DOI Listing
November 2017
17 Reads

High expression of hippocampal glutamic acid decarboxylase 67 mediates hypersensitivity of the hypothalamic-pituitary-adrenal axis in response to prenatal caffeine exposure in rats.

Toxicol Lett 2018 02 27;283:39-51. Epub 2017 Oct 27.

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03784274173144
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http://dx.doi.org/10.1016/j.toxlet.2017.10.019DOI Listing
February 2018
13 Reads

Current and future treatment options for pemphigus: Is it time to move towards more effective treatments?

Int Immunopharmacol 2017 Dec;53:133-142

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Systemic administration of corticosteroid (CS) remains the standard gold treatment for pemphigus. However, because of several long-term adverse effects, steroid-sparing agents are usually prescribed in combination with CSs. Despite the high number of available studies, the choice of best drugs to treat pemphigus remains controversial. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769173040
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http://dx.doi.org/10.1016/j.intimp.2017.10.027DOI Listing
December 2017
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Malignant pheochromocytoma with multiple vertebral metastases causing acute incomplete paralysis during pregnancy: Literature review with one case report.

Medicine (Baltimore) 2017 Nov;96(44):e8535

aDepartment of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences bDepartment of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College cDepartment of Neurosurgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China dDepartment of Neurosurgery, Wayne State University School of Medicine, Detroit, MI.

Rationale: We present a rare case of malignant pheochromocytoma with thoracic metastases during pregnancy that presented with symptoms of myelopathy and was treated with circumferential decompression, stabilization, and radiation. The management of this unique case is not well documented. The clinical manifestations, imaging results, pathological characteristics, treatment and prognosis of the case were analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000008535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682838PMC
November 2017
14 Reads