1,539 results match your criteria Adrenal Crisis


Β-Adrenergic agonist administration is not associated with secondary carcinoid crisis in patients with carcinoid tumor.

Am J Surg 2019 Jan 3. Epub 2019 Jan 3.

Division of Surgical Oncology, Oregon Health & Science University, United States. Electronic address:

Background: Patients with carcinoid tumors are at risk for profound intraoperative hypotension known as carcinoid crisis, which catecholamines are traditionally believed to trigger. However, data supporting this are lacking.

Methods: Anesthesia records were retrospectively reviewed for carcinoid patients treated with vasopressors. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2018.12.070DOI Listing
January 2019

Takotsubo Cardiomyopathy: Is It Due to Adrenal Crisis or Sjogren's Flare?

Cardiol Res 2018 Dec 7;9(6):378-380. Epub 2018 Dec 7.

University of Kansas School of Medicine-Wichita, 1010 N Kansas, Wichita, KS 67214, USA.

Takotsubo cardiomyopathy is a form of reversible cardiomyopathy. It is usually due to sudden emotional or physical stress. It is associated with excessive sympathetic stimulation and catecholamine release. Read More

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http://dx.doi.org/10.14740/cr759wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306119PMC
December 2018

An unusual altered biodistribution of F-FDG on PET/CT: diffuse perimuscular uptake in the setting of acute adrenal crisis.

Eur J Nucl Med Mol Imaging 2019 Jan 7. Epub 2019 Jan 7.

Department of Radiology, Nuclear Medicine Section, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1007/s00259-018-4247-1DOI Listing
January 2019

Adrenal hypoplasia congenita in identical twins.

Saudi Med J 2019 Jan;40(1):87-92

Unit of Pediatric Endocrinology and Diabetes, Maternity and Children Hospital, Dammam, Kingdom of Saudi Arabia. E-mail.

We are presenting a monozygotic twin brothers presented at different ages with different presentations. Twin-A presented at age of 18 days with salt losing crisis. Investigations revealed high plasma renin with low-normal aldosterone. Read More

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http://dx.doi.org/10.15537/smj.2019.1.23337DOI Listing
January 2019

Management of Adrenal Insufficiency Risk After Long-term Systemic Glucocorticoid Therapy in Duchenne Muscular Dystrophy: Clinical Practice Recommendations.

J Neuromuscul Dis 2019 Jan 2. Epub 2019 Jan 2.

Department of Pediatrics, Division of Endocrinology, University of Colorado School of Medicine, Aurora, Colorado, USA.

Long-term glucocorticoid therapy has improved outcomes in patients with Duchenne muscular dystrophy. However, the recommended glucocorticoid dosage suppresses the hypothalamic-pituitary-adrenal axis, leading to adrenal insufficiency that may develop during severe illness, trauma or surgery, and after discontinuation of glucocorticoid therapy. The purpose of this review is to highlight the risk of adrenal insufficiency in this patient population, and provide practical recommendations for management of adrenal insufficiency, glucocorticoid withdrawal, and adrenal function testing. Read More

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https://www.medra.org/servlet/aliasResolver?alias=iospress&a
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http://dx.doi.org/10.3233/JND-180346DOI Listing
January 2019
1 Read

Pheochromocytoma presenting with severe hyperglycemia and metabolic acidosis following intra-articular glucocorticoid administration: a case report.

J Med Case Rep 2019 Jan 5;13(1). Epub 2019 Jan 5.

Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8555, Japan.

Background: There are several reports of pheochromocytoma crisis triggered by systemic glucocorticoid administration. However, pheochromocytoma crisis after intra-articular glucocorticoid administration has been rarely reported.

Case Presentation: A 45-year-old Japanese man presented to our hospital with a sudden, severe headache. Read More

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http://dx.doi.org/10.1186/s13256-018-1945-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320610PMC
January 2019
1 Read

Graves' Thyrotoxicosis Leading to Adrenal Decompensation and Hyperandrogenemia in a Pediatric Patient with Salt-Wasting Congenital Adrenal Hyperplasia.

Case Rep Endocrinol 2018 22;2018:2359205. Epub 2018 Nov 22.

Pediatric Endocrinology, Rhode Island Hospital/The Warren Alpert Medical School of Brown University, 111 Plain Street, 3rd Floor, Providence, RI 02903, USA.

Introduction: Thyroid hormone is known to accelerate glucocorticoid turnover. In a thyrotoxic state, individuals with adrenal insufficiency are unable to increase endogenous cortisol production to compensate for increased turnover, placing them at risk for symptoms of glucocorticoid deficiency and adrenal crisis. In patients with salt-wasting congenital adrenal hyperplasia (SW-CAH), hyperandrogenemia is a measurable reflection of relative glucocorticoid insufficiency. Read More

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http://dx.doi.org/10.1155/2018/2359205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282132PMC
November 2018
1 Read

Return to the Emergency Room with or without Readmission after Endoscopic Transsphenoidal Surgery in Socioeconomically Disadvantaged Patients at an Urban Medical Center.

World Neurosurg 2018 Dec 19. Epub 2018 Dec 19.

Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA; Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, New Jersey, USA; Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA. Electronic address:

Background: Although reducing 30-day hospital readmission is now a priority in neurosurgical quality improvement, postoperative emergency room (ER) visits remain poorly understood, particularly in populations with limited access to outpatient care. After endoscopic transsphenoidal surgery (ETS), the unique pathologies treated may engender a variety of surgical and metabolic complications-often dangerous, delayed, and non-specific in presentation.

Objective: To characterize the causes and timing of ER visits-with or without readmission-in this socioeconomically disadvantaged population. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183286
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http://dx.doi.org/10.1016/j.wneu.2018.12.039DOI Listing
December 2018
2 Reads

Computed tomography-guided cryoablation for adrenal metastases: local control and survival.

Medicine (Baltimore) 2018 Dec;97(51):e13885

Department of Oncology, Second Affiliated Hospital of Suzhou University, Suzhou.

To evaluate the feasibility, local control, and survival after computed tomography (CT)-guided cryoablation for adrenal metastases.This study included 31 consecutive patients with adrenal metastases who were treated by CT-guided cryoablation in our center from July 2011 to October 2017. The technical success rate, local progression rate, local progression-free survival (LPFS), systemic progression-free survival (SPFS), and overall survival were assessed. Read More

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http://dx.doi.org/10.1097/MD.0000000000013885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320079PMC
December 2018
5.723 Impact Factor

An Update on Addison's Disease.

Exp Clin Endocrinol Diabetes 2018 Dec 18. Epub 2018 Dec 18.

Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany.

Addison's disease - the traditional term for primary adrenal insufficiency (PAI) - is defined as the clinical manifestation of chronic glucocorticoid- and/or mineralocorticoid deficiency due to failure of the adrenal cortex which may result in an adrenal crisis with potentially life-threatening consequences. Even though efficient and safe pharmaceutical preparations for the substitution of endogenous gluco- and mineralocorticoids are established in therapy, the mortality in patients with PAI is still increased and the health-related quality of life (HRQoL) is often reduced.PAI is a rare disease but recent data report an increasing prevalence. Read More

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http://dx.doi.org/10.1055/a-0804-2715DOI Listing
December 2018
7 Reads
1.760 Impact Factor

Prolonged adrenal insufficiency after high-dose glucocorticoid in infants with leukemia.

Pediatr Hematol Oncol 2018 Nov 20:1-7. Epub 2018 Nov 20.

a Department of Pediatrics , Ehime University Graduate School of Medicine , Ehime , Japan.

Although outcomes for infant leukemia have improved recently, transient adrenal insufficiency is commonly observed during treatment, especially after glucocorticoid administration. We identified three infants with acute leukemia who suffered from prolonged adrenal insufficiency requiring long-term (from 15 to 66 months) hydrocortisone replacement. All infants showed life-threatening symptoms associated with adrenal crisis after viral infections or other stress. Read More

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https://www.tandfonline.com/doi/full/10.1080/08880018.2018.1
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http://dx.doi.org/10.1080/08880018.2018.1539148DOI Listing
November 2018
15 Reads

Adrenal crisis presented as acute onset of hypercalcemia and hyponatremia triggered by acute pyelonephritis in a patient with partial hypopituitarism and pre-dialysis chronic kidney disease.

CEN Case Rep 2018 Nov 19. Epub 2018 Nov 19.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.

A 57-year-old woman with pre-dialysis chronic kidney disease (CKD) was hospitalized because of fever and fatigue. On admission, increased inflammatory response and pyuria with bacteriuria were observed. Pyelonephritis was successfully treated with antibiotics, whereas her fatigue continued and she developed progressive hypercalcemia and hyponatremia; serum sodium level, 116 mEq/L and corrected serum calcium level, 13. Read More

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http://link.springer.com/10.1007/s13730-018-0371-9
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http://dx.doi.org/10.1007/s13730-018-0371-9DOI Listing
November 2018
13 Reads

Polyglandular endocrine emergency: lessons from a patient, which a book cannot teach.

BMJ Case Rep 2018 Nov 8;2018. Epub 2018 Nov 8.

Department of Diabetes and Endocrinology, Royal Glamorgan Hospital, Llantrisant, UK.

A 30-year-old woman with polyglandular autoimmune type 2 syndrome was found collapsed at home with a cardiac arrest, which required direct current cardioversion. On admission, she was hypothermic, hypotensive and bradycardic. Initial biochemical investigations were consistent with a pre-renal acute kidney injury, metabolic acidosis and a possible sepsis. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22650
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http://dx.doi.org/10.1136/bcr-2018-226503DOI Listing
November 2018
18 Reads

Long-term follow-up in a Chinese child with congenital lipoid adrenal hyperplasia due to a StAR gene mutation.

BMC Endocr Disord 2018 Nov 6;18(1):78. Epub 2018 Nov 6.

Department of Endocrinology, Shenzhen Children's Hospital, 7019# Yitian Road, Futian District, Shenzhen, 518038, Guangdong Province, China.

Background: Congenital lipoid adrenal hyperplasia (CLAH) is an extremely rare and the most severe form of congenital adrenal hyperplasia. Typical features include disorder of sex development, early-onset adrenal crisis and enlarged adrenal glands with fatty accumulation.

Case Presentation: We report a case of CLAH caused by mutations in the steroidogenic acute regulatory protein (StAR) gene. Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-018-0307-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219181PMC
November 2018
6 Reads
1.673 Impact Factor

Hemodynamic instability during percutaneous ablation of extra-adrenal metastases of pheochromocytoma and paragangliomas: a case series.

BMC Anesthesiol 2018 Nov 6;18(1):158. Epub 2018 Nov 6.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine and Science, 200 First Street SW, Rochester, MN, 55905, USA.

Background: Surgical manipulation of pheochromocytomas and paragangliomas (PPGLs) may induce large hemodynamic oscillations due to catecholamine release. Little is known regarding hemodynamic instability during percutaneous ablation of PPGLs. We examined intraprocedural hemodynamic variability and postoperative complications related to percutaneous ablation of extra-adrenal metastases of PPGL. Read More

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https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12871-018-0626-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220566PMC
November 2018
7 Reads

Increasing Immunization Rates in Infants with Severe Chronic Lung Disease: A Quality Improvement Initiative.

Hosp Pediatr 2018 Nov;8(11):693-698

Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Objectives: Immunizations provide important protection from serious childhood illnesses. Infant chronic lung disease (CLD) is a serious complication of prematurity and predisposes premature infants to respiratory morbidity, rehospitalization, and mortality. This high-risk group is especially vulnerable to infections, such as invasive pneumococcal disease, influenza, and bronchiolitis. Read More

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http://dx.doi.org/10.1542/hpeds.2018-0046DOI Listing
November 2018
14 Reads

Pheochromocytoma in Congenital Cyanotic Heart Disease.

Case Rep Endocrinol 2018 25;2018:2091257. Epub 2018 Sep 25.

Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.

Studies on genome-wide transcription patterns have shown that many genetic alterations implicated in pheochromocytoma-paraganglioma (P-PGL) syndromes cluster in a common cellular pathway leading to aberrant activation of molecular response to hypoxia in normoxic conditions (the pseudohypoxia hypothesis). Several cases of P-PGL have been reported in patients with cyanotic congenital heart disease (CCHD). Patients affected with CCHD have an increased likelihood of P-PGL compared to those affected with noncyanotic congenital heart disease. Read More

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https://www.hindawi.com/journals/crie/2018/2091257/
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http://dx.doi.org/10.1155/2018/2091257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176301PMC
September 2018
3 Reads

Intracerebral hemorrhage as a first sign of pheochromocytoma: case report and review of the literature.

Endokrynol Pol 2018 Oct 23. Epub 2018 Oct 23.

Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center, Belgrade, Serbia; Medical Faculty, University of Belgrade, Belgrade, Serbia.

Pheochromocytomas and sympathetic paragangliomas are rare catecholamine-secreting tumors and represent very rare causes of intracerebral hemorrhage in young, with only few cases reported. A 32-year-old man presented to our emergency department because of sudden onset of severe headache. He had a six months history of paroxysmal headache, palpitations and sweating. Read More

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http://dx.doi.org/10.5603/EP.a2018.0075DOI Listing
October 2018
9 Reads

Russell's Viper Envenomation-Associated Addisonian Crisis.

Wilderness Environ Med 2018 Dec 8;29(4):504-507. Epub 2018 Oct 8.

Department of Internal Medicine, Trichy SRM Medical College Hospital and Research Center, Irungalur, Trichy, India (Prof Thirumalaikolundusubramanian).

Snakebite envenomation is an important public health problem in tropical countries. We report a case of bilateral adrenal hemorrhage in a 28-y-old man with Russell's viper bite that occurred in the Sathyamangalam forest range in the Indian state of Tamil Nadu. In this case, a combination of early bite recognition, hospital-based supportive care, corticosteroid therapy, and timely administration of polyvalent antivenom resulted in a favorable clinical outcome. Read More

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http://dx.doi.org/10.1016/j.wem.2018.06.001DOI Listing
December 2018
4 Reads

Adrenoleukodystrophy: Guidance for Adrenal Surveillance in Males Identified by Newborn Screen.

J Clin Endocrinol Metab 2018 Nov;103(11):4324-4331

Pediatric Endocrine Unit, Massachusetts General Hospital for Children and Harvard Medical School, Boston, Massachusetts.

Context: Adrenoleukodystrophy (ALD) is a peroxisomal disorder associated with neurologic decompensation and adrenal insufficiency. Newborn screening for ALD has recently been implemented in five states with plans to expand to all 50 states in the United States. Adrenal insufficiency ultimately develops in most males with ALD, but the earliest age of onset is not well established. Read More

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
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http://dx.doi.org/10.1210/jc.2018-00920DOI Listing
November 2018
11 Reads

Posaconazole-induced hypertension and hypokalemia due to inhibition of the 11β-hydroxylase enzyme.

Clin Kidney J 2018 Oct 30;11(5):691-693. Epub 2018 Jan 30.

Department of Pediatrics, Division of Endocrinology, Washington University, St. Louis, MO, USA.

Posaconazole is an antifungal therapy reported to cause incident hypertension. Hypokalemia is also a known side effect. The combination of hypertension and hypokalemia suggests mineralocorticoid excess. Read More

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http://dx.doi.org/10.1093/ckj/sfx156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165748PMC
October 2018
9 Reads

Involvement of DHH and GLI1 in adrenocortical autograft regeneration in rats.

Sci Rep 2018 Sep 28;8(1):14542. Epub 2018 Sep 28.

Department of Anatomy and Cell Science, Kansai Medical University, Hirakata, Osaka, 573-1010, Japan.

Bilateral adrenalectomy forces the patient to undergo glucocorticoid replacement therapy and bear a lifetime risk of adrenal crisis. Adrenal autotransplantation is considered useful to avoid adrenal crisis and glucocorticoid replacement therapy. However, the basic process of regeneration in adrenal autografts is poorly understood. Read More

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http://dx.doi.org/10.1038/s41598-018-32870-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162278PMC
September 2018
2 Reads

Outcomes of Adrenal Venous Sampling in Patients with Bilateral Adrenal Masses and ACTH-Independent Cushing's Syndrome.

World J Surg 2019 Feb;43(2):527-533

Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA, USA.

Background: Management of patients with bilateral adrenal masses and ACTH-independent Cushing's syndrome (AICS) is challenging, as bilateral adrenalectomy can lead to steroid dependence and lifelong risk of adrenal crisis. Adrenal venous sampling (AVS) has been previously reported to facilitate lateralization for guiding adrenalectomy. The aim of the current study was to investigate the utility of AVS using protocol from study by Young et al. Read More

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http://dx.doi.org/10.1007/s00268-018-4788-2DOI Listing
February 2019
5 Reads

Vanishing of ruptured adrenal mass with takotsubo cardiomyopathy.

Endocr J 2018 Dec 8;65(12):1155-1159. Epub 2018 Sep 8.

Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8640, Japan.

A 45-year-old male suddenly experienced left-flank abdominal pain. Echocardiography revealed akinesis of the 'takotsubo cardiomyopathy' type. He experienced a sudden haemodynamic collapse (blood pressure, 324/154 mmHg; pulse rate, 180 beats/min) during emergency cardiac catheterisation. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0119DOI Listing
December 2018
4 Reads

Masking and misleading: concomitant actinomycosis and B-cell lymphoma - a case report and review of literature.

Scott Med J 2018 Aug 30:36933018789312. Epub 2018 Aug 30.

2 Consultant Infectious Diseases Physician, Infectious Diseases Unit, Penang General Hospital, Penang, Malaysia.

We report a 72-year-old patient who presented with an ulcerated palatal mass, weight loss and adrenal insufficiency. Repeated biopsies from the mass revealed actinomycosis with no features of malignancy, while computed tomography scanning revealed a left maxillary sinus mass with invasive features and bilateral large adrenal masses. Blood and urine investigations showed adrenal insufficiency. Read More

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http://dx.doi.org/10.1177/0036933018789312DOI Listing
August 2018
5 Reads

A Sarcoidosis Patient Presents with Adrenal Insufficiency: A Standardized Patient Scenario for Medical Students and Residents.

Cureus 2018 Jun 18;10(6):e2833. Epub 2018 Jun 18.

Emergency Medicine/ Medical Simulation, Mayo Clinic, Jacksonville, USA.

Introduction The widespread use of corticosteroids for treatment of inflammatory conditions has resulted in the need to promptly recognize drug-induced adrenal insufficiency. This scenario was inspired by an actual case and aims to enhance critical thinking. Our case is unique as we use a case-based format with written tests to track progress. Read More

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http://dx.doi.org/10.7759/cureus.2833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101462PMC
June 2018
14 Reads

What about my daughter's future? Parental concerns when considering female genital restoration surgery in girls with congenital adrenal hyperplasia.

J Pediatr Urol 2018 Oct 23;14(5):417.e1-417.e5. Epub 2018 Jul 23.

Division of Pediatric Urology, Riley Hospital for Children at IU Health, IN, USA.

Purpose: The parental decision-making process regarding female genital restoration surgery (FGRS) for girls with congenital adrenal hyperplasia (CAH) is controversial and poorly understood. The aim of the study aim was to evaluate parental concerns related to their child's future and parental plans about disclosure prior to FGRS.

Materials And Methods: The authors performed an online survey of consecutive parents presenting at a tertiary referral center for consultation regarding FGRS for their daughter with CAH before 3 years of age (2016-2018). Read More

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http://dx.doi.org/10.1016/j.jpurol.2018.07.010DOI Listing
October 2018
1 Read

Extreme and Cyclical Blood Pressure Elevation in a Pheochromocytoma Hypertensive Crisis.

Case Rep Endocrinol 2018 15;2018:4073536. Epub 2018 Jul 15.

Division of General Surgery, McGill University Health Centre, Montréal, QC, Canada.

Pheochromocytomas are rare adrenal neoplasms characterized by excess secretion of catecholamines. We describe the case of a 65-year-old man, known for hypertension, with no family history of hereditary pheochromocytoma syndromes. He reported a two-year history of flushing, systolic blood pressure surges to 200 mmHg, headaches, tremors, and syncope. Read More

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http://dx.doi.org/10.1155/2018/4073536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077531PMC
July 2018
1 Read

Bilateral adrenal hemorrhage in antiphospholipid syndrome. Anticoagulation for the treatment of hemorrhage.

Saudi Med J 2018 Aug;39(8):829-833

Department of Internal Medicine, King Fahad Military Medical Complex, Dhahran, Kingdom of Saudi Arabia. E-mail.

A 43-year-old man with Hashimoto's thyroiditis and previous thromboembolic events treated with warfarin for 6 months, presented with right flank pain accompanied with vomiting, dizziness, and altered mental status 2 weeks after discontinuation of warfarin. His clinical examination findings were unremarkable. Routine blood work showed lymphopenia, thrombocytopenia, and hypoosmolar hyponatremia. Read More

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http://dx.doi.org/10.15537/smj.2018.8.22437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194995PMC
August 2018
3 Reads

Diagnostic and surgical challenges of a giant pheochromocytoma in a resource limited setting-A case report.

Int J Surg Case Rep 2018 1;50:111-115. Epub 2018 Aug 1.

Department of Pathology, College of Health Sciences, University of Zimbabwe. Electronic address:

Introduction: Pheochromocytomas are catecholamine producing tumours which arise from chromaffin cells within the adrenal medulla. Patients with these tumours commonly present with a triad of headache, palpitations and hypertension.

Case Presentation: We present a case of a 37-year-old male patient who presented with dull left sided abdominal pain and discomfort for 6 weeks. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.07.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091315PMC
August 2018
3 Reads

A Case of Brugada Pattern Associated with Adrenal Insufficiency.

Cureus 2018 Jun 6;10(6):e2752. Epub 2018 Jun 6.

Internal Medicine, Yale New Haven Health at Bridgeport Hospital, Bridgeport, USA.

Brugada syndrome (BrS) is an inherited channelopathy disease, caused by genetic changes in transmembrane ion channels. It has an increased risk of sudden cardiac death (SCD) in the absence of a structural heart disease. We report a case in which the presenting electrocardiogram (EKG) exhibited a type 1 Brugada-like pattern during an adrenal crisis with transformation into a type 2 Brugada-like pattern as the crisis improved. Read More

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http://dx.doi.org/10.7759/cureus.2752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080736PMC
June 2018
2 Reads

Smith-Lemli-Opitz syndrome presenting as acute adrenal crisis in a child: a case report.

J Med Case Rep 2018 Aug 10;12(1):217. Epub 2018 Aug 10.

University Paediatric Unit, Colombo North Teaching Hospital, Ragama, Sri Lanka.

Background: Smith-Lemli-Opitz syndrome is a rare autosomal recessive disorder of cholesterol biosynthesis which is characterized by multiple congenital malformations and global developmental delay. Here we report the case of a 3-year-old, previously undiagnosed, child with Smith-Lemli-Opitz syndrome presenting with acute adrenal crisis, which is an extremely rare and atypical presentation of this disease.

Case Presentation: A 3-year-old Sri Lankan Sinhalese boy without evidence of infection presented with circulatory collapse. Read More

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http://dx.doi.org/10.1186/s13256-018-1738-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085650PMC
August 2018
2 Reads

Variations in the management of acute illness in children with congenital adrenal hyperplasia: An audit of three paediatric hospitals.

Clin Endocrinol (Oxf) 2018 Nov 24;89(5):577-585. Epub 2018 Sep 24.

School of Medicine, Sydney, The University of Notre Dame Australia, Darlinghurst, New South Wales, Australia.

Objective: Episodes of acute adrenal insufficiency (AI)/adrenal crises (AC) are a serious consequence of congenital adrenal hyperplasia (CAH). This study aimed to assess morbidity from acute illness in CAH and identify factors associated with use of IV hydrocortisone, admission and diagnosis of an AC.

Method: An audit of acute illness presentations among children with CAH to paediatric hospitals in New South Wales, Australia, between 2000 and 2015. Read More

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http://dx.doi.org/10.1111/cen.13826DOI Listing
November 2018
19 Reads
3.460 Impact Factor

Latent Adrenal Insufficiency: Concept, Clues to Detection, and Diagnosis.

Endocr Pract 2018 08 7;24(8):746-755. Epub 2018 Aug 7.

In 1855, Thomas Addison described an illness now known as Addison disease (AD) caused by damage to the adrenal cortex and manifesting in weakness, weight loss, hypotension, gastrointestinal disturbances, and brownish pigmentation of the skin and mucous membranes. Corticosteroid supplementation, corticotropin (adrenocorticotropic hormone [ACTH] of medicinal use) test, and anti-adrenal auto-antibodies (AA) have come into use in the 100 years since Addison's death. Following the methodological innovations, 4 disorders which share impaired response to corticotropin in common have been discovered (i. Read More

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http://dx.doi.org/10.4158/EP-2018-0114DOI Listing
August 2018
2 Reads

Lesson of the month 2: Blunt abdominal trauma: atypical presentation of phaeochromocytoma.

Clin Med (Lond) 2018 Aug;18(4):345-347

Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

A 26-year-old man presented following blunt abdominal trauma to a regional major trauma centre for emergency embolisation of a retroperitoneal bleed from a presumed renal laceration. Imaging had also revealed a large right suprarenal mass. Embolisation resulted in a hypertensive crisis raising the suspicion of a metabolically active adrenal tumour. Read More

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http://dx.doi.org/10.7861/clinmedicine.18-4-345DOI Listing
August 2018
5 Reads

Surgical outcomes of patients with primary aldosteronism lateralized with I-131-6 β-iodomethyl-norcholesterol single photon emission/computed tomography without discontinuation or modification of antihypertensive medications.

Ci Ji Yi Xue Za Zhi 2018 Jul-Sep;30(3):169-175

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan.

Objectives: Adrenocortical scintigraphy for patients with primary aldosteronism (PA) without discontinuation or modification of antihypertensive medications is of concern because of drug interference with the renin-angiotensin-aldosterone system. We report the surgical outcomes of patients with PA lateralized with adrenocortical scintigraphy without drug discontinuation or modification.

Materials And Methods: We retrospectively reviewed 34 patients with PA with computed tomography (CT)-documented adrenal tumors who had undergoing subsequent I-131-6 β-iodomethyl-norcholesterol (NP-59) single photon emission CT (SPECT)/CT followed by unilateral adrenalectomy according to the results of NP-59 uptake between May 2005 and December 2014. Read More

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http://dx.doi.org/10.4103/tcmj.tcmj_106_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047325PMC
August 2018
2 Reads

Tuberculous Adrenal Abscess Presenting as Adrenal Insufficiency in a 4-Year-Old Boy.

J Trop Pediatr 2018 Jul 27. Epub 2018 Jul 27.

Division of Pediatric Endocrinology, Bai Jerbai Wadia Hospital for Children, Mumbai, India.

We describe the case of a 4.8-year-old boy who presented with adrenal crisis. The advent of symptoms of adrenal insufficiency in the patient was at around 2 years of age. Read More

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http://dx.doi.org/10.1093/tropej/fmy046DOI Listing
July 2018
5 Reads
0.860 Impact Factor

Functional Pituitary Tissue Generation from Human Embryonic Stem Cells.

Curr Protoc Neurosci 2018 04;83(1):e48

Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.

The anterior pituitary gland produces several hormones essential for regulation of the somatic endocrine system. Deficiency of these hormones can cause life-threatening diseases, including adrenal crisis. Pituitary tissue generated from human pluripotent stem cells is expected to provide better treatment than current hormone replacement therapy. Read More

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http://dx.doi.org/10.1002/cpns.48DOI Listing
April 2018
2 Reads

Acute Adrenal Insufficiency in the Perioperative Period: A Case Report.

A A Pract 2018 Jul 16. Epub 2018 Jul 16.

From the Department of Anesthesiology & Perioperative Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania.

Acute adrenal insufficiency is a rare but potentially life-threatening event during the perioperative period. The usual manifestations of an acute adrenal crisis can mimic common postoperative complications and a high index of suspicion is required for the diagnosis. Early diagnosis and prompt treatment can be lifesaving. Read More

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http://dx.doi.org/10.1213/XAA.0000000000000846DOI Listing
July 2018
12 Reads

[The 464th case: sudden convulsion and coma in a patient with acute leukemia].

Zhonghua Nei Ke Za Zhi 2018 Jul;57(7):539-541

Peking University People's Hospital, Peking University Institute of Hematology, Beijing 100044, China.

A 46-year-old female patient was diagnosed as mixed phenotype acute leukemia with chief complaints of intermittent gingival swelling and bleeding for 1 week. The induction chemotherapy was not effective. During the second course chemotherapy, the patient had sudden convulsion and coma. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2018.07.017DOI Listing
July 2018
5 Reads

Heterozygous mutations in the cholesterol side-chain cleavage enzyme gene (CYP11A1) can cause transient adrenal insufficiency and life-threatening failure to thrive.

Hormones (Athens) 2018 Jul 11. Epub 2018 Jul 11.

Division of Pediatric Endocrinology, Third Department of Pediatrics, Attikon University Hospital, Haidari, Athens, Greece.

The first and rate-limited step of steroidogenesis in all steroidogenic tissues is the conversion of cholesterol to pregnenolone, catalysed by P450scc side-chain cleavage enzyme (CYP11A1 gene-SCC). SCC deficiency has been characterised as an autosomal recessive disorder, although it may also be inherited as an autosomal dominant trait in humans. Here, we describe a family of three members carrying the same novel heterozygous CYP11A1 mutation, a c. Read More

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http://dx.doi.org/10.1007/s42000-018-0048-yDOI Listing
July 2018
7 Reads

Retro-peritoneal paraganglioma, diagnosis and management.

Prog Urol 2018 Sep 5;28(10):488-494. Epub 2018 Jul 5.

Urology department, Charles Nicolle hospital, Faculty of Medecine of Tunis, Tunis El Manar University, Tunis, Tunisia. Electronic address:

Introduction: Paragangliomas, defined as extra-adrenal chromaffin-cells tumors, are rarely located in the retro-peritoneum. Clinical presentation is similar to pheochromocytoma, and mainly depends on the producing character of the tumor. Positive diagnosis requires plasmatic and urinary hormonal assays. Read More

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http://dx.doi.org/10.1016/j.purol.2018.06.003DOI Listing
September 2018

Adrenal Insufficiency in Young Children: a Mixed Methods Study of Parents' Experiences.

J Genet Couns 2018 Dec 7;27(6):1447-1458. Epub 2018 Jul 7.

Genetic Alliance UK, 49-51 East Road, London, N1 6AH, UK.

Research into adrenal insufficiency (AI) and congenital adrenal hyperplasia (CAH) in children has focused largely on clinical consequences for patients; and until recently, the wider experience of the condition from the perspective of other family members has been neglected. In a mixed methods study, we captured the experiences of parents of young children affected by AI/CAH, including their views on the psychosocial impact of living with and managing the condition. Semi-structured interviews were carried out in the UK and an online survey was developed, translated and disseminated through support groups (UK and the Netherlands) and outpatient endocrinology clinics (Germany). Read More

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http://dx.doi.org/10.1007/s10897-018-0278-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209050PMC
December 2018
2 Reads

Predictive Factors of Operative Hemodynamic Instability for Pheochromocytoma.

Am Surg 2018 Jun;84(6):920-923

Pheochromocytoma is an uncommon catecholamine-secreting tumor in which resection is often associated with hemodynamic instability (HI). In this study, we aim to clarify the factors affecting surgical HI in patients who underwent surgery with the diagnosis of pheochromocytoma. All patients who underwent surgery with the diagnosis of pheochromocytoma between 2008 and 2015 were analyzed retrospectively. Read More

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June 2018
12 Reads

Pheochromocytoma and Paraganglioma in Neurofibromatosis type 1: frequent surgeries and cardiovascular crises indicate the need for screening.

Clin Diabetes Endocrinol 2018 22;4:15. Epub 2018 Jun 22.

2Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan Health System, Medical Science Research Building II, Office # 2560e, 1150 West Medical Center Drive, Ann Arbor, MI 48109 USA.

Background: Pheochromocytomas and Paragangliomas (PCC/PGL) are rare endocrine tumors that are mostly benign, but often hormone producing, causing significant morbidity and mortality due to excess catecholamine secretion and cardiovascular crises. It is estimated that 30% of PCC/PGL are due to germline mutations, including Neurofibromatosis type 1 (). There is little published data describing the phenotype of NF1-associated PCC/PGL and there are no established recommendations for PCC/PGL screening in NF1. Read More

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http://dx.doi.org/10.1186/s40842-018-0065-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013983PMC
June 2018
5 Reads

Study of adrenal function in patients with tuberculosis.

Indian J Tuberc 2018 Jul 7;65(3):241-245. Epub 2017 Oct 7.

Professor and Head, Department of Biochemistry, Sri Guru Ram Das Institute of Medical Sciences & Research, Vallah, Amritsar, India.

Background: Although subclinical adrenal insufficiency has been documented in tuberculosis but it has been neglected in mainstream management of TB due to inconclusive data on its prevalence in TB. The fact that adrenal insufficiency may result not only in poor general condition of the patient but also sudden death due to adrenal crisis, makes it all the more important to address this issue seriously. In this non-randomized interventional study comprising of 100 cases of TB, our aim was to assess the adreno-cortical functions in patients with pulmonary TB (50 cases) and extra-pulmonary TB (50 cases) in an attempt to determine if there is any compromise of adrenal function. Read More

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http://dx.doi.org/10.1016/j.ijtb.2017.08.033DOI Listing
July 2018
10 Reads

Pheochromocytoma crisis presenting with hypotension, hemoptysis, and abnormal liver function: A case report.

Medicine (Baltimore) 2018 Jun;97(25):e11054

Division of Endocrinology and Metabolism.

Rationale: Pheochromocytomas are rare catecholamine-secreting tumors arising from adrenomedullary chromaffin cells, usually causing hypertension, palpitation and headache. However, pheochromocytoma crisis, on the contrary, might present with hypotension, multiple organ dysfunction or even mimicking other diseases, leaving physician with diagnostic difficulties. In this study, we present a case featured hypotension, shock and multiple organ dysfunction syndrome on admission, which nearly lead us to miss the diagnosis of pheochromocytoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000011054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023654PMC
June 2018
5 Reads

[CME: Adrenal Insufficiency].

Authors:
Stefan Fischli

Praxis (Bern 1994) 2018 Jun;107(13):717-725

1 Abteilung Endokrinologie, Diabetologie und Klinische Ernährung, Departement Innere Medizin, Luzerner Kantonsspital.

CME: Adrenal Insufficiency Abstract. Patients suffering from adrenal insufficiency (AI) often present with unspecific symptoms. Therefore, the diagnosis of AI, a potential life-threatening condition, can be missed. Read More

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http://dx.doi.org/10.1024/1661-8157/a002982DOI Listing
June 2018
10 Reads

Adrenal crisis in a 14-year-old boy 12 years after hematopoietic stem cell transplantation.

Endocrinol Diabetes Metab Case Rep 2018 6;2018. Epub 2018 Jun 6.

Divisions of Pediatric Endocrinology, Department of Pediatric and Adolescent Medicine, University Hospital of Erlangen, Erlangen, Germany.

We report on a boy of Albanian descent with the history of juvenile myelomonocytic leukemia (JMML). JMML was diagnosed at the age of 17 months and treated by hematopoietic stem cell transplantation (HSCT). At the age of 14. Read More

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http://dx.doi.org/10.1530/EDM-18-0034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993059PMC
June 2018
11 Reads