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Tech Vasc Interv Radiol 2020 Jun 25;23(2):100676. Epub 2020 May 25.

Miami Cardiac and Vascular Institute, Miami Cancer Institute, Miami, FL. Electronic address:

Incidental adrenal masses are common and are found in 4% of the CT scans. While clinical history, laboratory results, and imaging characteristics are typically sufficient for diagnosis of an adrenal lesion, a biopsy is sometimes warranted. In some cases, adrenal mass ablation is subsequently indicated. Read More

Ann Surg 2020 Jun 11. Epub 2020 Jun 11.

Department of Endocrine Surgery, Cleveland Clinic, Cleveland, OH.

Objective: The aim of this study was to analyze the incidence of and risk factors for adrenocortical carcinoma (ACC) in adrenal incidentaloma (AI).

Summary Of Background Data: AI guidelines are based on data obtained with old-generation imaging and predominantly use tumor size to stratify risk for ACC. There is a need to analyze the incidence and risk factors from a contemporary series. Read More

BMC Surg 2020 Jun 10;20(1):128. Epub 2020 Jun 10.

Department of Hepatobiliary Surgery, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China, 325000.

Background: Hepatic adrenal ectopia is a common clinical diagnosis, whereas adrenal tumors developed from hepatic adrenal ectopia are rare. Hepatic adrenal tumors are easily misdiagnosed as hepatic carcinoma and frequently treated by unnecessary operations.

Case Presentation: A 50-year-old female patient was hospitalized due to B-ultrasonic detection of "right focal liver lesions. Read More

Endocrine 2020 May 10. Epub 2020 May 10.

Department of Endocrinology, Aix-Marseille University, INSERM U1251, Endo-ERN Reference Center for Rare Genetic Tumor Syndromes, Assistance Publique-Hopitaux de Marseille, Marseille, France.

Multiple endocrine neoplasia type 2 (MEN2) is a rare hereditary syndrome due to mutations of the proto-oncogene REarranged during Transfection (RET), defined by the association of medullary thyroid carcinoma (MTC) in almost 100% cases, and pheochromocytoma in roughly 50% (primary hyperparathyroidism can be seen in 10-20% of patients with MEN2A). Early thyroidectomy and the efficacy of novel tyrosine kinase inhibitors modified the natural history of MTC, with possibilities of cure or long-term control. The second main compound, pheochromocytoma, is reported with a variable penetrance, from 10 to 80% cases, depending on the mutation of RET. Read More

Gan To Kagaku Ryoho 2020 Feb;47(2):304-306

Dept. of Surgery, Kansai Rosai Hospital.

Hepatocellular carcinoma with bile duct invasion is rare, with a reported incidence of 3.4%. A 71-year-old man with hepatocellular carcinoma underwent radiofrequency ablation(RFA)(S6, S7, S8)and required readmission 22 months after the RFA for hepatocellular carcinoma recurrence detected by gadoxetic acid-enhanced magnetic resonance imaging. Read More

Eur Rev Med Pharmacol Sci 2020 Apr;24(8):4172-4179

Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.

Objective: Hepatocellular carcinoma (HCC) is one of the most common fatal cancer in the world and androgens are among the possible etiological factors. Congenital adrenal hyperplasia (CAH) is a group of inherited diseases caused by enzyme failure in the steroid biosynthesis of the adrenal cortex, resulting in an augmented 17-hydroxyprogesterone, androstenedione and testosterone production. While the occurrence of testicular adrenal rest tumors and adrenocortical tumors in congenital adrenal hyperplasia is well described in the literature, no data on HCC occurrence are available. Read More

Circ Cardiovasc Imaging 2020 May 6;13(5):e010058. Epub 2020 May 6.

Department of Cardiology (N.A.-S.), Royal Cornwall Hospital NHS Trust.

J Card Surg 2020 Jun 30;35(6):1380-1382. Epub 2020 Apr 30.

Department of Thoracic and Cardiovascular Surgery, Evangelismos General Hospital, Athens, Greece.

Intravascular tumor extension in the inferior vena cava (IVC) is known to occur with abdominal tumors, such as renal cell, hepatocellular, adrenal cell carcinoma, and Wilm's tumor. We encountered a 53-year-old male patient presenting with pulmonary embolism and a right atrial mass with imaging evidence of an adrenal tumor extending into the IVC, up to the right atrium. The patient underwent surgery for the resection of the tumor using cardiopulmonary bypass by a team of cardiothoracic surgeons and urologists. Read More

Hinyokika Kiyo 2020 Mar;66(3):91-96

The Department of Urology, Miyazaki University Hospital.

A 73-year-old Japanese man visited the urology clinic with the chief complaint of gross hematuria in June 2015. His prostate specific antigen (PSA) level was 146.7 ng/ml and he was diagnosed with prostate adenocarcinoma with a Gleason Score of 5+4. Read More

Cancers (Basel) 2020 Apr 10;12(4). Epub 2020 Apr 10.

Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia at ASST Spedali Civili, 25123 Brescia, Italy.

Etoposide, doxorubicin and cisplatin plus oral mitotane (EDP-M) comprise the reference regimen in the management of patients with adrenocortical carcinoma (ACC). In this paper, we described the outcome of 58 patients with advanced/metastatic ACC consecutively treated with EDP-M in a reference center for this rare disease in Italy. In this series, EDP-M obtained a partial response in 50% of patients; median progression free survival (PFS) and overall survival were 10. Read More

Endocr J 2020 Apr 4. Epub 2020 Apr 4.

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Adrenocortical carcinoma (ACC) is a rare aggressive tumor originating from adrenocortical parenchymal cells and its incidence is approximately 1 per million population per year. An oncocytic ACC is a recently identified entity among the several known histopathological variants of ACC, which is characterized by oncocytic cells, and only a few cases in the available literature have reported this tumor. In contrast to conventional ACCs, oncocytic ACCs usually manifest as solitary lesions presenting in adults without any sex predilection. Read More

Urol Case Rep 2020 Jul 26;31:101148. Epub 2020 Feb 26.

Division of Urology, UConn Health, 263 Farmington Avenue, Farmington, CT, 06030-8073, USA.

Androgen-secreting adrenal neoplasms have a low incidence, usually secrete multiple hormones, and may present with hirsutism, acne, and alopecia. We report an exceedingly rare case of a purely dehydroepiandrosterone-sulfate (DHEA-S) secreting adrenal neoplasm found incidentally on cross sectional imaging. The clinical, biochemical, and pathologic findings of this neoplasm are described. Read More

Mol Clin Oncol 2020 Apr 24;12(4):317-320. Epub 2020 Jan 24.

Second Department of Surgery, School of Medicine, National and Kapodistrian University of Athens, Aretaieion University Hospital, 11528 Athens, Greece.

Adrenal leiomyosarcomas are rare mesenchymal tumors of the suprarenal region that are usually diagnosed after they have reached a large size. We report the case of a 62-year-old male with an incidentally found left adrenal mass. Magnetic resonance imaging of the retroperitoneal space showed a heterogeneously enhanced mass, measuring 10x8. Read More

Abdom Radiol (NY) 2020 04;45(4):1001-1010

Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

The evaluation and management of adrenal disease is a complex endeavor that relies on an expert knowledge of human physiology and anatomy. Careful and proper patient assessment mandates a balanced approach which marries the disciplines of endocrinology, surgery, and radiology. Any of these three specialties may be on the front line in performing the initial workup when an adrenal neoplasm is discovered. Read More

J Immunother Cancer 2020 03;8(1)

Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: Patients with advanced rare cancers have poor prognosis and few treatment options. As immunotherapy is effective across multiple cancer types, we aimed to assess pembrolizumab (programmed cell death 1 (PD-1) inhibitor) in patients with advanced rare cancers.

Methods: In this open-label, phase 2 trial, patients with advanced rare cancers whose tumors had progressed on standard therapies, if available, within the previous 6 months were enrolled in nine tumor-specific cohorts and a 10th cohort for other rare histologies. Read More

Cell Death Dis 2020 Mar 17;11(3):192. Epub 2020 Mar 17.

Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Würzburg, Würzburg, Germany.

Conditions of impaired adrenal function and tissue destruction, such as in Addison's disease, and treatment resistance of adrenocortical carcinoma (ACC) necessitate improved understanding of the pathophysiology of adrenal cell death. Due to relevant oxidative processes in the adrenal cortex, our study investigated the role of ferroptosis, an iron-dependent cell death mechanism and found high adrenocortical expression of glutathione peroxidase 4 (GPX4) and long-chain-fatty-acid CoA ligase 4 (ACSL4) genes, key factors in the initiation of ferroptosis. By applying MALDI mass spectrometry imaging to normal and neoplastic adrenocortical tissue, we detected high abundance of arachidonic and adrenic acid, two long chain polyunsaturated fatty acids which undergo peroxidation during ferroptosis. Read More

Am J Case Rep 2020 Mar 15;21:e921353. Epub 2020 Mar 15.

Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.

BACKGROUND Microscopic tumor foci have been detected incidentally on renal biopsy, including renal cell carcinoma and renomedullary interstitial cell tumor (medullary fibroma). A report is presented of a case of an incidental finding of microscopic renal angiomyolipoma that was diagnosed and completely excised on core needle biopsy. CASE REPORT A 44-year-old woman was referred to our hospital for evaluation of persistent mild proteinuria. Read More

J Vet Intern Med 2020 Mar 11;34(2):626-635. Epub 2020 Mar 11.

Department of Veterinary Medical Science, Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Background: Percutaneous ultrasound (US)-guided fine-needle aspiration (FNA) of adrenal gland lesions is controversial in veterinary medicine.

Objective: To evaluate the frequency and radiologists' perception of the risk of the procedure as well as determining the incidence of complications.

Methods: Retrospective study. Read More

Gan To Kagaku Ryoho 2019 Dec;46(13):2312-2314

Dept. of Surgery, Fukuoka Tokushukai Hospital.

A 55-year-old man was admitted to our hospital for jaundice. Magnetic resonance cholangiopancreatography showed a mass in the pancreatic head as well as biliary obstruction. We strongly suspected invasive ductal carcinoma of the pancreas. Read More

Wideochir Inne Tech Maloinwazyjne 2020 Mar 15;15(1):106-111. Epub 2019 May 15.

Department of Surgery, Faculty of Medicine, Aydin University, VM Medical Park Florya Hospital, Istanbul, Turkey.

Introduction: The laparoscopic adrenalectomy (LA) has become the gold standard since the transperitoneal laparoscopic approach was first reported.

Aim: To evaluate the applicability, safety and short-term results of laparoscopic surgery in adrenal masses over 6 cm.

Material And Methods: Demographic data, hormonal activities, imaging modalities, operative findings, operation time, conversion rates, complications, duration of hospital stay and histopathologic results of 128 patients who underwent laparoscopic adrenalectomy were evaluated retrospectively. Read More

Clin Radiol 2020 Jun 20;75(6):479.e17-479.e22. Epub 2020 Feb 20.

Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

Aim: To determine the value of contrast-enhanced computed tomography (CT)-derived radiomic features in the preoperative prediction of Ki-67 expression in adrenocortical carcinoma (ACC) and to detect significant associations between radiomic features and Ki-67 expression in ACC.

Materials And Methods: For this retrospective analysis, patients with histopathologically proven ACC were reviewed. Radiomic features were extracted for all patients from the preoperative contrast-enhanced abdominal CT images. Read More

Endocrine 2020 Apr 22;68(1):203-209. Epub 2020 Feb 22.

Division of Endocrinology, Department of Medicine, Research Center, Centre hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada.

Purpose: Recent guidelines on adrenal incidentalomas suggested in patients with an indeterminate adrenal mass and no significant hormone excess that follow up with a repeat noncontrast CT or MRI after 6-12 months may be an option.

Methods: We report the case of a 32-year-old woman who presented with a 2.9 × 1. Read More

Middle East J Dig Dis 2020 Jan;12(1):48-51

Department of Pathology, University of Pennsylvania, Philadelphia, PA, USA.

Hepatocellular carcinoma (HCC) is the commontumor of the liver and the third most common cause of cancer-related mortality worldwide. Patients with HCC may have metastasis to different sites. Intrahepatic and extrahepatic metastases are found in (~50-75%). Read More

Int Urol Nephrol 2020 Jun 18;52(6):1057-1071. Epub 2020 Feb 18.

Department of Urology, The Fifth Affiliated Hospital, Sun Yat-Sen University, No. 52, Meihua East Road, Zhuhai, 519000, Guangdong, China.

Background: Predicting the prognosis of patients with adrenocortical carcinoma (ACC) is difficult, due to its unpredictable behavior. The aim of this study is to develop and validate a nomogram to predict survival outcomes in patients with ACC.

Methods: Nomograms were established using the data collected from the Surveillance, Epidemiology, and End Results (SEER) database. Read More

G Chir 2019 Jul-Aug;40(4):348-354

Background: Laparoscopic adrenalectomy is the standard management of benign adrenal tumors. Open adrenalectomy is still the gold standard surgical treatment for adrenocortical carcinoma and malignant pheochromocytoma, while the role of minimal invasive surgery is still controversial. Laparoscopic adrenalectomy is associated with low morbidity rate, short hospital stay and rapid recovery to work. Read More

Medicine (Baltimore) 2020 Jan;99(3):e18812

Breast Center, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, PR China.

Rationale: Breast cancer is the most commonly diagnosed malignancies in females. The most common sites of metastasis are bone, lung, liver, and brain. Gastrointestinal and adrenal gland metastasis from breast cancer are rare. Read More

Curr Med Imaging Rev 2019 ;15(5):435-442

Department of Radiology I, Maria Skłodowska-Curie Memorial Cancer Centre, Institute of Oncology, Ul. Roentgena 5, 02-781 Warszawa, Poland.

Background: Fat can be identified in numerous liver lesions, and usually is not a specific finding. Distinguishing between different kinds of fatty deposits is an important part of differential diagnosis. Magnetic Resonance Imaging (MRI) is superior to other imaging techniques because it allows distinguishing intracellular from macroscopic fat. Read More

World Neurosurg 2020 Jun 30;138:723-731. Epub 2020 Jan 30.

Department of Radiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou City, Fujian Province, China. Electronic address:

We selected 992 patients who presented to our hospital for treatment and were diagnosed with a neuroendocrine tumor (NET) between January 1, 2008, and December 31, 2018, of whom 17 were diagnosed with primary hepatic neuroendocrine neoplasm. The clinical data were analyzed to study the clinical value of computed tomography (CT) and magnetic resonance imaging data in the diagnosis of the disease. Nine tumors (52. Read More

Invest New Drugs 2020 Jan 27. Epub 2020 Jan 27.

Department of Investigational Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with very limited treatment options. Nevanimibe HCl (formerly ATR-101), a novel adrenal-specific sterol O-acyltransferase 1 (SOAT1) inhibitor, has been shown in nonclinical studies to decrease adrenal steroidogenesis at lower doses and to cause apoptosis of adrenocortical cells at higher doses. Methods This phase 1, multicenter, open-label study assessed the safety and pharmacokinetics (PK) of nevanimibe in adults with metastatic ACC (NCT01898715). Read More

Case Rep Urol 2019 21;2019:9794345. Epub 2019 Dec 21.

Advanced Urology Associates, Silvercross Hospital, New Lenox, IL, USA.

Background: Surgical resection remains the standard treatment for adrenocortical carcinoma. Higher rates of local and peritoneal recurrence have been reported with the laparoscopic approach compared to open resection, although the evidence is limited. A dilemma occurs when tumors appear benign in nature, measure >5 cm, or when patients request a minimally invasive surgical approach. Read More

Clin Diabetes Endocrinol 2020 6;6. Epub 2020 Jan 6.

1Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, 30-1 Kamicho, Oyaguchi, Itabashi-ku, Tokyo, 173-8610 Japan.

Background: The programmed cell death 1 (PD-1) inhibitor pembrolizumab is a promising agent for treatment of several different malignancies, but as with all immunotherapy there is a potential risk of immune-related adverse events. Adrenocorticotropic hormone (ACTH) deficiency and hypophysitis have been reported in patients treated with a different PD-1 inhibitor, nivolumab. However, clinical characteristics of these side effects associated with pembrolizumab have yet to be described in detail. Read More

Int J Surg Case Rep 2020 26;66:330-333. Epub 2019 Dec 26.

Faculty of Medicine, Department of Urology, Lebanese University, Beirut, Lebanon. Electronic address:

Background: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy, often with an unfavorable prognosis. Radical adrenalectomy is the gold standard of treatment of localized disease.

Case Description: We report a case of a 23-year-old male patient who presented with persistent left flank pain and urticaria for 3 months. Read More

Endocrinol Diabetes Metab Case Rep 2020 Jan 8;2020. Epub 2020 Jan 8.

Pediatric Oncology Branch, Rare Tumor Initiative, Center for Cancer Research, National Cancer Institute, Clinical Center.

Summary: Adrenocortical carcinoma (ACC) is an aggressive cancer that originates in the cortex of the adrenal gland and generally has a poor prognosis. ACC is rare but can be more commonly seen in those with cancer predisposition syndromes (e.g. Read More

Orv Hetil 2020 Jan;161(2):75-79

Belgyógyászati Intézet, Endokrinológia Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar Debrecen, Nagyerdei krt. 98., 4032.

The authors present the case of a multiplex endocrine neoplasia type 2A (MEN2A). The 55-year-old woman underwent detailed examinations for abdominal complaints. Bilateral adrenal masses and thyroid nodular goiter were found. Read More

Abdom Radiol (NY) 2020 04;45(4):945-963

Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77030, USA.

Adrenocortical carcinoma (ACC) is a rare tumor with a poor prognosis. Most tumors are either metastatic or locally invasive at the time of diagnosis. Differentiation between ACC and other adrenal masses depends on clinical, biochemical, and imaging factors. Read More

BMJ Case Rep 2019 Dec 30;12(12). Epub 2019 Dec 30.

Endocrinology and Metabolism, Sir Mortimer B Davis Jewish General Hospital, Montreal, Québec, Canada.

Hirsutism is a common medical presentation to family physicians, internists and endocrinologists. Although the cause is commonly benign, a more serious or life-threatening one should not be missed. Here we report a 58-year-old woman, assessed for hirsutism and 15-pound weight gain, with associated easy bruising and mood swings. Read More

BMC Cancer 2019 Dec 30;19(1):1265. Epub 2019 Dec 30.

Division of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, No.386, Ta-Chung 1st Rd, 81362, Kaohsiung, Taiwan.

Background: Ganglioneuromas (GNs) are composed of mature ganglion cells and Schwann cells with a fibrous stroma; GNs are most often observed in children and young adults. The majority of non-cranial GNs are located in the retroperitoneum and posterior mediastinum. Other reported rare sites include the adrenal gland, small intestine, colon and urinary bladder. Read More

Medicine (Baltimore) 2019 Dec;98(50):e18310

Department of Radiotherapy oncology, Shandong Provincial Qianfoshan Hospital, the First Hospital Affiliated with Shandong First Medical University.

Purpose: We designed the study to investigate the incidence risk of Programmed Cell Death-1 (PD-1) or Ligand 1 (PD-L1) inhibitor-related endocrine dysfunction in patients with lung cancer.

Method: All the data were collected by 1 primary reviewer and then independently reviewed by 2 secondary reviewers according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISM) guidelines. Incidence risk of all-grade and grade 3-5 PD-1/PD-L1 inhibitors related endocrine dysfunction in patients with lung cancer were taken into account. Read More

World J Surg Oncol 2019 Dec 16;17(1):220. Epub 2019 Dec 16.

Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

Background: To describe the pathological distribution, imaging manifestations, and surgical managements and prognosis of large adrenal tumors (LATs) ≥ 5 cm METHODS: A total of 251 patients with LATs were analyzed on the basis of pathological or clinical diagnosis. Regarding surgery, open adrenalectomy was performed on 89 patients, and laparoscopic adrenalectomy was performed on 89 patients. Thirty-two patients with bilateral tumors were analyzed in terms of clinical characteristics. Read More

Medicine (Baltimore) 2019 Dec;98(49):e18259

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences.

Rationale: Adrenocortical carcinoma is a rare aggressive type of cancer whose prognosis is poor, particularly for metastatic entities. Metastatic adrenocortical carcinoma in the spine is a rare disease with no standard curative managements yet. The objective of this study is to report a very rare case of spinal metastases of adrenocortical carcinoma successfully managed by combination of cement augmentation, radiotherapy together with adjuvant programmed cell death 1 (PD-1) therapy. Read More

Clin Nucl Med 2020 Apr;45(4):e192-e194

From the Departments of Radiology.

Hepatic adrenal rest include ectopic adrenal tissue in the liver and adrenohepatic fusion. Long-lasting hyperstimulation of that tissue induces hyperplasia sometimes simulating true tumors. True autonomic tumors originating from ectopic adrenal tissue with or without hyperfunction are rare. Read More

Case Rep Pathol 2019 20;2019:9137120. Epub 2019 Oct 20.

Department of Anatomic Pathology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.

Oncocytic adrenocortical neoplasms (OANs) are very rare. Although most cases have benign behavior, the risk of recurrence/metastasis is variable. Based on Lin-Weiss-Bisceglia (LWB) system criteria, OANs can be classified as benign, borderline, or malignant. Read More

Endocrinol Diabetes Metab Case Rep 2019 Nov 25;2019. Epub 2019 Nov 25.

Section on Endocrinology & Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.

Summary: Adrenococortical carcinoma (ACC) is a rare cancer, occurring at the rate of one case in two million person years. Cushing syndrome or a mixed picture of excess androgen and glucocorticoid production are the most common presentations of ACC. Other uncommon presentations include abdominal pain and adrenal incidentalomas. Read More

Diagn Pathol 2019 Nov 20;14(1):130. Epub 2019 Nov 20.

Gastroenterology Department, The First Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Background: Distant metastases from follicular thyroid carcinoma are mainly hematogenous and are commonly observed in the lungs and bones. Other rare sites are the parotid gland, skin, brain, ovary, adrenal gland, kidney, pancreas and breast, with chest wall lymph node metastasis being even more rare.

Case Presentation: Over the past 10 years, three surgeries were performed on a 69-year-old women with a history of follicular thyroid cancer and its metastatic lesions. Read More

J Endocr Soc 2019 Dec 11;3(12):2295-2304. Epub 2019 Oct 11.

Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora Colorado.

Adrenocortical carcinoma (ACC) is a rare orphan disease with a dismal prognosis. Surgery remains the first-line treatment, but most patients eventually develop metastatic disease. Mitotane is often used with chemotherapy with modest success. Read More

Cancers (Basel) 2019 Nov 9;11(11). Epub 2019 Nov 9.

Endocrinology, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome 00189, Italy.

Mitotane (MTT) is an adrenolytic drug used in adjuvant and advanced treatments of adrenocortical carcinoma (ACC). Ionizing radiation (IR) is also used in adrenal cancer treatment, even though its biological action remains unknown. To provide a reliable in vivo preclinical model of ACC, we used mouse xenografts bearing human ACC to test the effects of MTT and IR alone and in combination. Read More

Am J Respir Crit Care Med 2020 04;201(8):e52-e53

Department of Molecular and Internal Medicine, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2019 Oct;41(5):658-662

Department of Ultrasound,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

Objective To analyze the clinical features of Von-Hippel-Lindau(VHL)syndrome and explore the diagnostic value of abdominal ultrasound for this disease.Methods The clinical features including age at first diagnosis,symptoms,signs,affected organs,number of operations,and diagnostic examinations of 35 patients with VHL syndrome admitted to our center from January 1994 to December 2017 were retrospectively analyzed.The diagnostic value of abdominal ultrasound for VHL syndrome was analyzed. Read More

Abdom Radiol (NY) 2020 04;45(4):1057-1068

Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital and Women's College Hospital, University of Toronto, Toronto, ON, Canada.

Extension of tumor tissue within a vein is a recognized prognostic factor in abdominal malignancy because of its influence on tumor staging and selection of therapeutic management. With the advent of newer surgical techniques, and variable treatment strategies, imaging plays a crucial role in categorizing patients according to the tumor resectability and vascular reconstruction techniques during surgery. Understanding the clinical impact of tumor thrombus increases the awareness of the radiologist about the key findings in tumor staging and decision-making of surgical approach. Read More

Pan Afr Med J 2019 11;33:188. Epub 2019 Jul 11.

Radiothérapie-oncologie, Faculté de Médecine et de Pharmacie, Université Cadi Ayyad, Marrakech, Maroc.

Brain radionecrosis is a rare but life-threatening complication of external-beam radiotherapy for ENT cancers, in particular of the nasopharynx, and for brain tumors. Very few studies were conducted on this complication in the African population as well as in the Maghreb population. Therefore our study aims to describe the demographic, clinical, paraclinical, therapeutic and evolutionary features of cerebral radionecrosis in the Department of Neurology at the Mohammed V Military Teaching Hospital in Rabat over a period of 18 years (2000-2017). Read More