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Asia Ocean J Nucl Med Biol 2019 ;7(1):89-94

Tabriz University of Medical Sciences, Tabriz, Iran.

Colorectal carcinoma is one of the most common causes of cancer-related death, worldwide. Recently, due to the introduction of novel imaging and therapeutic techniques, five-year survival of patients has increased. However, distant metastasis is still expected in half of the patients. Read More

J Postgrad Med 2019 Jan-Mar;65(1):44-46

Division of Cardiology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

We report a 49-year-old woman who presented with a hypertensive crisis and acute heart failure and reduced left ventricular systolic function. An abdominal ultrasonography revealed a huge lobulated heterogeneous mass at the lower pole of the right kidney and a mass over the left suprarenal area, which were further delineated by magnetic resonance imaging. The patient underwent laparoscopic right radical nephrectomy and left adrenalectomy. Read More

J Magn Reson Imaging 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.

This article proposes a consensus nomenclature for fat-containing renal and adrenal masses at MRI to reduce variability, improve understanding, and enhance communication when describing imaging findings. The MRI appearance of "macroscopic fat" occurs due to a sufficient number of aggregated adipocytes and results in one or more of: 1) intratumoral signal intensity (SI) loss using fat-suppression techniques, or 2) chemical shift artifact of the second kind causing linear or curvilinear India-ink (etching) artifact within or at the periphery of a mass at macroscopic fat-water interfaces. "Macroscopic fat" is most commonly observed in adrenal myelolipoma and renal angiomyolipoma (AML) and only rarely encountered in other adrenal cortical tumors and renal cell carcinomas (RCC). Read More

Nanomedicine (Lond) 2019 Jan 29. Epub 2019 Jan 29.

Pós-graduação em Engenharia de Bioprocessos e Biotecnologia, Curitiba, Brazil.

Aim: To develop a monoclonal antibody against dehydroepiandrosterone (DHEA) and miniaturize it, generating a single-chain antibody variable fragment (scFv) against DHEA as an adrenocortical carcinoma (ACC) marker.

Material & Methods: DHEA conjugated to keyhole limpet hemocyanin was used as an immunogen to obtain anti-DHEA hybridomas. Variable fragments were cloned from hybridoma 5B7 total RNA, and used to detect DHEA in normal adrenal tissue and ACC cells. Read More

BMC Endocr Disord 2019 Jan 23;19(1):14. Epub 2019 Jan 23.

Department of Endocrinology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, 310003, Hangzhou, China.

Background: Hyperandrogenemia is more common in puberty and reproductive age, but relatively rare in postmenopausal women. Postmenopausal virilization may result from androgen-producing tumors. Androgen-secreting adrenal tumors are rare in clinical practice and are diagnosed as adrenocortical carcinoma, most of which can co-secrete androgen and cortisol. Read More

Medicine (Baltimore) 2019 Jan;98(3):e13770

Department of Gastroenterology, The Affiliated Drum Tower Hospital of Nanjing University, Medical School.

Rationale: Cancer recurrence and metastasis after liver transplantation (LT) is common in some hepatocellular carcinoma (HCC) patients. The most common sites of extrahepatic metastases are lung, regional lymph node, adrenal gland, and bone. To our knowledge, HCC metastasis to the seminal vesicle after LT has not been reported in the literature. Read More

Zhonghua Gan Zang Bing Za Zhi 2018 Nov;26(11):835-841

Department of Radiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.

To study the clinical value of transcatheter arterial chemoembolization (TACE) therapy for hepatocellular carcinoma with blood supply from right adrenal artery. An imaging and clinical data of HCC patients with blood supply from right adrenal artery were collected from 2012 to 2016 after TACE treatment in the Second Affiliated Hospital of Chongqing Medical University and the safety and therapeutic efficacy of complete embolization therapy was analyzed retrospectively. Twenty hepatocellular carcinoma patients with blood supply from right adrenal artery had received 23 times treatment. Read More

Endocr J 2018 Dec 19. Epub 2018 Dec 19.

Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China.

Cushing's syndrome (CS) is a clinical syndrome characterized by hypercortisolemia. Cyclic Cushing's syndrome (CCS), which exhibits a periodic or irregular increasing pattern in cortisol, is a rare type of Cushing's syndrome. A 37-year-old man came to our hospital because of repeated dizzy spells, weakness and hypercortisolemia lasting two weeks. Read More

BMJ Case Rep 2018 Dec 13;11(1). Epub 2018 Dec 13.

Urology, King George's Medical University, Lucknow, India.

J Adv Pract Oncol 2018 Jan-Feb;9(1):67-76. Epub 2018 Jan 1.

Duke Prostate Center, Durham, North Carolina.

Tom, a 75-year-old white male, was recently diagnosed with metastatic renal cell carcinoma (RCC; Tom's case is not an actual clinical case but has been developed by the authors as an exemplar). Two years prior, he had undergone a left partial (laparoscopic) nephrectomy for clear cell RCC. At that time, he had a stage 3 disease (the tumor extended into perinephric tissues but not into the ipsilateral adrenal gland and not beyond Gerota's fascia [Cancer. Read More

Cancers (Basel) 2018 Dec 15;10(12). Epub 2018 Dec 15.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Building 10, Room 1E-3140, Bethesda, MD 20892, USA.

Adrenocortical carcinoma (ACC) and pheochromocytoma and paraganglioma (PPGL) are defined by clinicopathological criteria and can be further sub-divided based on different molecular features. Whether differences between these molecular subgroups are significant enough to re-challenge their current clinicopathological classification is currently unknown. It is also not fully understood to which other cancers ACC and PPGL show similarity to. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13469

Department of Emergency Surgery, Union Hospital.

Rationale: About 50% of patients with a diagnosis of nonsmall cell lung carcinoma exhibit metastatic disease at the time of diagnosis. The preferential sites of extrapulmonary spread are the lymph nodes, liver, brain, adrenal glands, and bones; gastrointestinal tract perforation secondary to metastatic lung cancer is extremely rare.

Patient Concerns: A 60-year-old male nonsmoker patient presented with a 20-day history of facial, neck, and right upper limb edema. Read More

Hinyokika Kiyo 2018 Nov;64(11):435-438

The Department of Urology, Osaka National Hospital.

A 69-year-old woman was admitted to the previous hospital because of a right adrenal tumor detected by a medical checkup. Although the tumor was diagnosed as non-functional adrenal adenoma, abdominal computed tomography (CT) revealed a left renal mass which was suspected to be renal cell carcinoma. Chest CT seeking for metastatic lesions revealed lung cancer of the left lung. Read More

Pol Merkur Lekarski 2018 Nov;45(269):189-191

Maria Skłodowska-Curie Institute - Oncology Center of Warsaw, Poland: Department of Soft Tissue/Bone Sarcoma and Melanoma.

Primary adrenal leiomyosarcomas are very rare adrenal mesenchymal tumours, only few dozen has been reported in the English language literature so far. We present two cases of patients with primary adrenal leiomyoosarcomas. 80 year-old female admitted with left adrenal tumour with presumptive diagnosis of nonadenoma, laparoscopic adrenalectomy was performed and 85 year-old man who underwent surgical resection by laparotomy of adrenal tumour suspected for adrenal carcinoma. Read More

J Cancer Res Ther 2018 Oct-Dec;14(6):1422-1424

Department of Medical Oncology, Gazi University Faculty of Medicine, Ankara, Turkey.

Ewing's family of tumors is aggressive tumors and frequently arises from bone and soft tissue. They might also arise from nonosseous structures such as gastrointestinal tract, adrenal glands, or kidney. Primary renal Ewing's sarcoma (ES)/primitive neuroectodermal tumor is an extremely rare entity which has aggressive clinical course. Read More

Eur J Endocrinol 2018 Nov 1. Epub 2018 Nov 1.

M Kroiss, Department of Internal Medicine I, Division of Endocrinology and Diabetology, University Hospital Würzburg, Würzburg, Germany.

Objective: Current workup for the pre-operative distinction between frequent adrenocortical adenomas (ACA) and rare but aggressive adrenocortical carcinomas (ACC) combines imaging and biochemical testing. We here investigated the potential of plasma steroid hormone profiling by liquid chromatography tandem mass spectrometry (LC-MS/MS) for the diagnosis of malignancy in adrenocortical tumours.

Design: Retrospective cohort study of prospectively collected EDTA-plasma samples in a single tertiary reference center. Read More

Prog Urol 2018 Nov 27;28(12S):S175-S193. Epub 2018 Oct 27.

Service d'urologie, hôpital d'instruction des armées Sainte-Anne, BP 600, 83800 Toulon cedex 09, France; Service d'urologie, hôpital européen Georges-Pompidou, université Paris Descartes, AP-HP, 75015 Paris, France. Electronic address:

Objective: To update French oncology guidelines concerning adrenal cancer.

Methods: Comprehensive Medline search between 2016 and 2018 upon diagnosis, treatment and follow-up of adrenal cancer to update 2013 guidelines. Level of evidence was evaluated according to AGREE-II. Read More

Ann Surg Oncol 2019 Feb 15;26(2):531-538. Epub 2018 Nov 15.

Department of General, Viszeral, and Thoracic Surgery, Kreisklinik Altötting, Altötting, Germany.

Background: In the surgical treatment of adrenocortical carcinoma (ACC), lymphadenectomy may improve oncologic outcome. However, patterns of metastatic lymphatic spread in ACC are unknown.

Methods: Clinical data of patients included in the European Network for the Study of Adrenal Tumors (ENSAT) registry were retrospectively reviewed. Read More

Acta Clin Croat 2018 Jun;57(2):372-376

Department of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.

Papillary thyroid carcinoma (PTC) is considered one of the most favorable tumors, indolent, with rare distant dissemination. Lungs and bones are the most common metastatic sites. Unusual sites of PTC distant metastases are extremely rare. Read More

Medicine (Baltimore) 2018 Nov;97(46):e13200

Department of Radiology, Jinshan TCM-Integrated Hospital of Shanghai City, Shanghai.

Rationale: Clear cell renal cell carcinoma (CCRCC) metastasis to pancreas is clinically rare. Misdiagnosis for these cases is frequently due to the low incidence, lack of specific clinical symptoms, and laboratory results.

Patient Concerns: Three female patients aged 47 years, 69 years, and 76 years, respectively, were admitted to hospital for routine examination after resection of clear cell carcinoma of kidney for 69 months, 57 months, and 123 months, respectively. Read More

World J Clin Cases 2018 Nov;6(13):694-702

Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.

We report a case of natural killer (NK)/T-cell lymphoma with concomitant syndrome of inappropriate antidiuretic hormone secretion (SIADH). The patient was a 64-year-old woman with a history of nasopharyngeal carcinoma of over 30 years. She was admitted with a chief complaint of intermittent fever for 2 mo. Read More

Exp Clin Endocrinol Diabetes 2018 Nov 14. Epub 2018 Nov 14.

Department of Internal Medicine I, Endocrine and Diabetes Unit, University Hospital Würzburg, University of Würzburg, Germany.

Objective: Adrenocortical carcinoma (ACC) is a rare malignancy with a dismal prognosis. In advanced stages, tumour control by mitotane and cytotoxic chemotherapy is often temporary and salvage treatments are warranted.

Methods: Retrospective cohort study of participants in the prospective European Networks for the Study of Adrenal Tumours (ENSAT) registry. Read More

Case Rep Gastrointest Med 2018 3;2018:8196051. Epub 2018 Oct 3.

Division of Gastroenterology and Hepatology, University of Florida and Malcom Randall VA Medical Center, Gainesville, FL, USA.

Primary adrenal leiomyosarcoma (PAL) is an extremely rare mesenchymal tumor with only a few isolated case reports in the medical literature. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) or endoscopic ultrasound-guided core biopsy (EUS-CB) is a safe, effective modality for sampling lesions in the gastrointestinal tract and adjacent organs, including the adrenal glands. We describe the case of a 50-year-old male presenting with abdominal pain and unintentional weight loss over the course of one year. Read More

Indian J Nucl Med 2018 Oct-Dec;33(4):345-347

Department of Radiology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

A good percentage of adrenal masses in patients with known malignancy may be benign; thus, noninvasive characterization is important in preventing unnecessary biopsy. This case report represents a patient with papillary thyroid carcinoma and known lung metastasis for which she was followed up with whole-body fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) postradioactive iodine therapy. During the follow-up, she had developed an adrenal mass lesion seen by FDG PET/CT and further characterized by magnetic resonance imaging (MRI). Read More

J Surg Oncol 2018 Dec 27;118(8):1271-1276. Epub 2018 Oct 27.

Department of Urology, School of Medicine, Kyungpook National University, Daegu, Korea.

Background And Objectives: The adrenal gland is a frequent site for metastasis, and a solitary adrenal mass is often observed during staging workup or imaging follow-up in patients with extra-adrenal malignancy. To create an appropriate management plan, it is essential to distinguish between benign adrenal lesions and metastasis in patients with extra-adrenal cancer having solitary adrenal masses. Therefore, here we evaluated the predictive factors for adrenal metastasis in patients with extra-adrenal malignancy having solitary adrenal mass. Read More

Oncotarget 2018 Oct 2;9(77):34641. Epub 2018 Oct 2.

Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

[This corrects the article DOI: 10.18632/oncotarget.19945. Read More

Acta Med Indones 2018 Jul;50(3):257-259

Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran - Hasan Sadikin Hospital, Bandung, Indonesia.

Adrenocortical carcinoma (ACC) is a rare solid tumor with an incidence of 0.5 to 2 cases per million per year. It affects women more commonly than men with a ratio of 1. Read More

Quant Imaging Med Surg 2018 Sep;8(8):853-875

Department of Radiology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China.

Besides ultrasound and nuclear medicine techniques, computed tomography (CT) and magnetic resonance imaging (MRI) are commonly used to examine adrenal lesions in both symptomatic and asymptomatic patients. Some adrenal lesions have characteristic radiological features. If an adrenal nodule is discovered incidentally, determining whether the lesion is benign or malignant is of great importance. Read More

Eur J Endocrinol 2018 10 1;179(4):G1-G46. Epub 2018 Oct 1.

Department of Clinical and Biological Sciences, Internal Medicine, San Luigi Hospital, University of Turin, Orbassano, Italy

Adrenocortical carcinoma (ACC) is a rare and in most cases steroid hormone-producing tumor with variable prognosis. The purpose of these guidelines is to provide clinicians with best possible evidence-based recommendations for clinical management of patients with ACC based on the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system. We predefined four main clinical questions, which we judged as particularly important for the management of ACC patients and performed systematic literature searches: (A) What is needed to diagnose an ACC by histopathology? (B) Which are the best prognostic markers in ACC? (C) Is adjuvant therapy able to prevent recurrent disease or reduce mortality after radical resection? (D) What is the best treatment option for macroscopically incompletely resected, recurrent or metastatic disease? Other relevant questions were discussed within the group. Read More

Exp Oncol 2018 Oct;40(3):251-253

O.O. Bogomolets National Medical University, Kyiv 01601, Ukraine.

Adrenocortical cancer is an extremely rare tumor presenting with extensive locoregional spread at the time of diagnosis. Due to the diagnostic difficulties preoperatively and a lack of effective treatment options, patients have poor prognosis. Patients succumb to metastases within a couple of months. Read More

Endokrynol Pol 2018 27;69(6):682-687. Epub 2018 Sep 27.

Department of Internal Medicine, Division of Endocrinology and Metabolism, Kastamonu State Hospital, Kastamonu, Turkey.

Introduction: Oncocytomas of adrenal glands are extremely rare and usually present as incidentally detected masses. We aimed to present a series of patients with adrenal oncocytomas and review the literature.

Material And Methods: Electronic database of patients with adrenal tumours, who were admitted to the internal medicine and endocrinology and metabolism outpatient clinics of Uludag University Medical Faculty between January 2005 and November 2016, were assessed retrospectively. Read More

Ann Surg Oncol 2018 Nov 18;25(12):3460-3468. Epub 2018 Sep 18.

Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University, Nashville, TN, USA.

This is the first of a two-part review on adrenocortical carcinoma (ACC), a rare and aggressive malignancy that often presents at an advanced stage. Most patients present with symptoms related to cortisol and/or androgen excess. Appropriate biochemical evaluation and imaging is important in assessing the extent of disease, operative planning, and oncologic surveillance for patients with ACC. Read More

Mayo Clin Proc Innov Qual Outcomes 2018 Mar 21;2(1):30-39. Epub 2017 Dec 21.

Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN.

Objective: To characterize large adrenal tumors (≥4 cm in diameter) and to identify features associated with malignancy.

Patients And Methods: We investigated the clinical, biochemical, and imaging characteristics in a large retrospective single-center cohort of patients with adrenal tumors of 4 cm or more in diameter during the period of January 1, 2000, through December 31, 2014.

Results: Of 4085 patients with adrenal tumors, 705 (17%) had adrenal masses measuring 4 cm or more in diameter; of these, 373 (53%) were women, with a median age of 59 years (range, 18-91 years) and median tumor size of 5. Read More

Am J Case Rep 2018 Sep 15;19:1096-1102. Epub 2018 Sep 15.

Department of General Surgery, Istituto Clinico Sant'Ambrogio, Milan, Italy.

BACKGROUND Adrenocortical oncocytic neoplasms (AONs) are extremely rare tumors. AONs are classified as: oncocytoma (AO), oncocytic neoplasm of uncertain malignant potential (AONUMP), and oncocytic carcinoma (AOC). Among the 162 reported cases of AONs in the literature, 30 cases were classified as malignant. Read More

Ann Hepatobiliary Pancreat Surg 2018 Aug 31;22(3):287-291. Epub 2018 Aug 31.

Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.

The incidence of combined hepatocellular carcinoma-cholangiocarcinoma (cHCC-CC) in a single patient accounts for only 0.4 to 14% of all primary liver cancer. However, the prognosis of its intrahepatic cholangiocarcinoma (ICC) component is poor. Read More

BMJ Case Rep 2018 Sep 4;2018. Epub 2018 Sep 4.

Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.

Endocrinol Diabetes Metab Case Rep 2018 23;2018. Epub 2018 Aug 23.

Starship Children's Health, Auckland District Health Board, Auckland, New Zealand.

Adrenocortical carcinoma (ACC) during childhood is a rare malignant tumor that frequently results in glucocorticoid and/or androgen excess. When there are signs of microscopic or macroscopic residual disease, adjuvant therapy is recommended with mitotane, an adrenolytic and cytotoxic drug. In addition to the anticipated side effect of adrenal insufficiency, mitotane is known to cause gynecomastia and hypothyroidism in adults. Read More

Thorac Cancer 2018 Nov 24;9(11):1513-1518. Epub 2018 Aug 24.

Department of Medical Oncology, The First Hospital, China Medical University, Shenyang, China.

Distant metastases of pulmonary adenocarcinoma are regularly observed in the bones, brain, adrenal gland, and liver, but rarely in the breast or cervix. In this report, we describe a novel case of concurrent cervix and breast metastases from lung adenocarcinoma, with ALK rearrangements that were strongly consistent between the primary and metastatic cancers. A 44-year-old Chinese woman with a chief complaint of abdominal discomfort was referred to our hospital. Read More

Ann Nucl Med 2018 Dec 17;32(10):658-668. Epub 2018 Aug 17.

Department of Urology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.

Purpose: To compare findings obtained with C-choline and FDG PET/CT scanning for renal cell carcinoma staging and restaging.

Materials And Methods: Twenty-eight renal cell carcinoma patients whose histological subtype was clear cell type in 26 and papillary type in 2, while Fuhrman nuclear grade was G1,2 in 16 and G3,4 in 12, underwent both C-choline and FDG PET/CT examinations before (n = 10) and/or after (n = 18) treatment, then those scanning modalities were compared in regard to patient- and lesion-based diagnostic performance using 5 grading scores. Final diagnosis in each case was obtained based on histopathology, conventional radiological imaging, and clinical follow-up findings. Read More

BMJ Case Rep 2018 Aug 16;2018. Epub 2018 Aug 16.

Department of Urology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

In patients with prostate cancer, metastases mostly develop in bone, lung, liver, pleura and adrenal glands. Prostate carcinoma metastases to the ureter are very rare, and the peritoneum is an even rarer site of prostate metastases. We present two cases of ureteral metastases of prostate cancer, of which one patient also developed malignant ascites and peritoneal metastases. Read More

BMJ Case Rep 2018 Aug 16;2018. Epub 2018 Aug 16.

Internal Medicine Department, Hospital Garcia de Orta, Almada, Portugal.

Ectopic adrenocorticotropic hormone (ACTH) secretion represents 5%-10% of cases of Cushing's syndrome (CS), and approximately 50%-60% of these arise from neuroendocrine lung tumours, including small-cell lung cancer (SCLC). We report a 42-year-old man admitted with hypertension, metabolic alkalosis and severe hypokalaemia. On physical examination, centripetal obesity with 'moon face' and 'buffalo's hump' were identified, and wheezing on left lung was heard. Read More

Radiol Case Rep 2018 Oct 3;13(5):949-951. Epub 2018 Aug 3.

Institute for Advanced Biomedical Technologies, Via Luigi Polacchi, 11, 66100 Chieti, Italy.

A 47-year-old female diagnosed with well-differentiated papillary thyroid carcinoma was referred to our center for a Iodine whole body scintigraphy as follow-up. The patient had been previously treated with total thyroidectomy and ablative dose of 175mCi I three years ago. Diagnostic I scan showed a zone of radioiodine uptake in posterior aspect of the left upper quadrant of the abdomen. Read More

J Pak Med Assoc 2018 Aug;68(8):1267-1269

Jinnah Postgraduate Medical Center, Karachi.

28 years old, male patient was diagnosed with Metastatic Adrenocortical Carcinoma after extensive investigation. Patient's primary concern was only his right hip and right shoulder pain. On imaging investigations, the patient was diagnosed with Avascular Necrosis of the right hip joint. Read More

Nihon Shokakibyo Gakkai Zasshi 2018 ;115(8):755-759

Department of Surgery, Tsu Seikyo Hospital.

A 78-year-old woman had undergone total gastrectomy and chemotherapy for gastric cancer (pT4N3bM0 Stage IIIC, poorly differentiated adenocarcinoma). She received S-1 monotherapy 3 times weekly (S-1 at 80mg twice daily for 14 days, every 3 weeks). She underwent routine examinations, including tumor markers and computed tomography. Read More

Cancer Imaging 2018 Jul 31;18(1):24. Epub 2018 Jul 31.

Department of Interventional Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, People's Republic of China.

Background: This study investigated the safety and efficacy of transcatheter arterial chemoembolization (TACE) with simultaneous radiofrequency ablation (RFA) as treatment for adrenal metastases (AM) from hepatocellular carcinoma(HCC).

Methods: The records of 63 patients with AM who were treated at our Hospital between February 2013 and August 2016 were retrospectively reviewed. Patients were divided into a TACE+RFA group (n = 38) and a control group that received TACE alone (n = 25) according to different treatment methods. Read More

Eur J Endocrinol 2018 Jul 24. Epub 2018 Jul 24.

M Terzolo, San Luigi Hospital, University of Turino, Orbassano, Italy.

Adrenocortical carcinoma (ACC) is a rare and in most cases steroid hormone producing tumor with variable prognosis. The purpose of these guidelines is to provide clinicians with best possible evidence-based recommendations for clinical management of patients with ACC based on the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system. We predefined four main clinical questions, which we judged as particularly important for the management of ACC patients and performed systematic literature searches: (A) What is needed to diagnose an ACC by histopathology? (B) Which are the best prognostic markers in ACC? (C) Is adjuvant therapy able to prevent recurrent disease or reduce mortality after radical resection? (D) What is the best treatment option for macroscopically incompletely resected, recurrent or metastatic disease? Other relevant questions were discussed within the group. Read More

Congenit Heart Dis 2018 Jul 22;13(4):608-616. Epub 2018 Jul 22.

Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Objective: Pheochromocytoma and paraganglioma (extra-adrenal pheochromocytoma) are rare neuroendocrine tumors that arise from the neuroendocrine cells. Chronic hypoxia is known as a possible cause, and a strong link between cyanotic congenital heart disease and these tumors has been reported. However, reports of phechromocytoma/paraganglioma in Fontan patients were scarce. Read More

Urol Clin North Am 2018 Aug;45(3):365-387

Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street Unit 1473, Houston, TX 77030, USA.

Various pathologies can affect the adrenal gland. Noninvasive cross-sectional imaging is used for evaluating adrenal masses. Accurate diagnosis of adrenal lesions is critical, especially in cancer patients; the presence of adrenal metastasis changes prognosis and treatment. Read More

Asia Ocean J Nucl Med Biol 2018 ;6(2):179-185

Department of Pathology and Genetics, Dubai Hospital, Dubai Health Authority, Dubai, UAE.

F-18 FDG is the most widely used tracer in molecular imaging and it is applied for many purposes mainly in malignant diseases. Incidental finding are common in FDG-PET/CT imaging and includes benign and malignant lesions. Among the rare tumors‎, adrenal oncocytomas are uncommon findings and incidental findings of thyroid malignancies are not rare. Read More

Case Rep Surg 2018 7;2018:9607972. Epub 2018 Jun 7.

Division of Surgical Oncology, Department of Surgery, Eastern Virginia Medical School, 825 Fairfax Ave, Norfolk VA 23507, USA.

Objective: We present a case of an adrenal hemangioma, an uncommon cause of an adrenal mass, and review the clinical presentation, work-up, and management of adrenal incidentalomas.

Background: A 64-year-old male was found to have a right adrenal incidentaloma during work-up for elevated liver transaminase levels, later found to be from hepatitis C. The mass was suspicious for adrenocortical carcinoma on CT imaging. Read More