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    1 OF 190

    Multiples of Median-Transformed, Normalized Reference Ranges of Steroid Profiling Data Independent of Age, Sex, and Units.
    Horm Res Paediatr 2018 Apr 25:1-10. Epub 2018 Apr 25.
    Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University Medical Center SH, Campus Kiel, Kiel, Germany.
    Background/aims: The high complexity of pediatric reference ranges across age, sex, and units impairs clinical application and comparability of steroid hormone data, e.g., in congenital adrenal hyperplasia (CAH). Read More

    Indocyanine green identification for tumor infiltration or metastasis originating from hepatocellular carcinoma.
    Int J Surg Case Rep 2018 Apr 16;46:56-61. Epub 2018 Apr 16.
    Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
    Introduction: The indocyanine green-photodynamic eye (ICG-PDE) system is useful to detect small hypervascular liver tumors, hepatocellular carcinoma (HCC), on the liver surface. This system may be also applied to improve determining the location of metastasis or tumor thrombus (TT). We herein report three case reports. Read More

    Ghrelin as a potential molecular marker of adrenal carcinogenesis: in vivo and in vitro evidence.
    Clin Endocrinol (Oxf) 2018 Apr 23. Epub 2018 Apr 23.
    Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Science, Poznan, Poland.
    Context: Adrenal tumors belong to one of the most prevalent neoplasms. It is a heterogeneous group with different etiology, clinical manifestation, and prognosis. Its histopathologic diagnosis is difficult and identification of differentiation markers for tumorigenesis is extremely valuable for diagnosis. Read More

    Interobserver agreement in distinguishing large adrenal adenomas and adrenocortical carcinomas on computed tomography.
    Abdom Radiol (NY) 2018 Apr 19. Epub 2018 Apr 19.
    Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Purpose: Large adrenal masses pose a diagnostic dilemma. The purpose of this study was twofold: first, to assess the degree of interobserver agreement in evaluating the morphology of pathologically proven adrenal adenomas and adrenocortical carcinomas larger than 4 cm in diameter; and second, to identify morphologic characteristics that correlated with the pathologic diagnosis.

    Materials And Methods: For this blinded, retrospective study, we collected cases of 25 adrenal adenomas and 33 adrenocortical carcinomas measuring larger than 4 cm. Read More

    β-Catenin-driven adrenocortical carcinoma is characterized with immune exclusion.
    Onco Targets Ther 2018 9;11:2029-2036. Epub 2018 Apr 9.
    Department of Urology, Huashan Hospital, Shanghai, China.
    Aim: Adrenocortical carcinoma (ACC) is characterized by overexpressed , which is reported to modulate immune exclusion. Cross talk between and cancer immunity in ACC remains unclear.

    Materials And Methods: In silico reproduction of TCGA-ACC dataset (N = 92) and external validation using tissue samples were performed (N = 16). Read More

    A rare cause of dysregulated metabolic syndrome: cortisol-producing adrenocortical carcinoma.
    Neth J Med 2018 Apr;76(3):129-131
    Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
    Adrenocortical carcinoma is a rare and highly malignant disease which can cause hypercortisolism leading to dysregulation of blood pressure and glucose levels. Most patients present with advanced disease. We describe the classic presentation of a functional adrenocortical carcinoma in a patient with metabolic syndrome. Read More

    Histopathologic Findings in Canine Pituitary Glands.
    Vet Pathol 2018 Jan 1:300985818766211. Epub 2018 Jan 1.
    6 Department of Internal Medicine, Small Animal Hospital of Veterinary Faculty, University of Tehran, Tehran, Iran.
    To optimize the histologic evaluation of hypophysectomy specimens, sections of 207 canine pituitary glands (196 postmortem, 11 hypophysectomy specimens) were reviewed. Adenohypophyseal proliferation was the most common (n = 79) lesion. Proliferative lesions were sparsely to densely granulated; the granules were usually basophilic to chromophobic and periodic acid-Schiff-positive. Read More

    PAX8-Positive B-Cell Lymphoma in Adrenal Gland Masquerading as Metastatic Renal Cell Carcinoma.
    Int J Surg Pathol 2018 Apr 1:1066896918770022. Epub 2018 Apr 1.
    1 University of Washington Medical Center, Seattle, WA, USA.
    Extranodal lymphomas involve adrenal glands as a mass lesion in 3% to 5% of cases as identified by imaging studies. Definitive diagnosis of the neoplasm is provided by morphological and immunophenotypical evaluation on limited tissue obtained by fine needle aspiration or core biopsy. We report a diagnostically challenging case that presented as masses involving adrenal gland and lung in the setting of a concurrent primary renal cell carcinoma. Read More

    Pedunculated Hepatocellular Carcinoma Mimicking Right Adrenal Tumor on FDG PET/CT.
    Clin Nucl Med 2018 Apr 13. Epub 2018 Apr 13.
    Pedunculated hepatocellular carcinoma is an unusual form of hepatocellular carcinoma protruding from the liver with or without a pedicle. We present a case of pedunculated hepatocellular carcinoma misdiagnosed as right adrenal tumor on MRI and FDG PET/CT. Intraoperative exploration revealed the mass was attached to the liver, but the right adrenal gland was intact. Read More

    [An Elderly Case of Recurrent Neuroendocrine Carcinoma of the Stomach Treated with Ramucirumab].
    Gan To Kagaku Ryoho 2018 Mar;45(3):557-559
    Dept. of Surgery, Nishijin Hospital.
    An 84-years-old man underwent total gastrectomy with D1 plus lymph node dissection in December 2015, and diagnosed as Stage III B neuroendocrine carcinoma of the stomach. An abdominal computed tomography revealed swollen paraaortic lymph nodes and left adrenal grand in May 2016. Since his serum level of CA19-9 was elevated, he was thus diagnosed as having recurrence, and was started chemotherapy with ramucirumab(RAM). Read More

    Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitor use in the management of resistant hypercholesterolemia induced by mitotane treatment for adrenocortical cancer.
    J Clin Lipidol 2018 Mar 13. Epub 2018 Mar 13.
    Department of Endocrinology, Ioannina University Hospital, Ioannina, Greece. Electronic address:
    We report the case of a patient with probable heterozygous familial hypercholesterolemia and mitotane-induced resistant hypercholesterolemia, despite combination therapy with rosuvastatin and ezetimibe. The patient was managed with the addition of evolocumab. Use of a proprotein convertase subtilisin-kexin type 9 inhibitor, should be considered in patients who develop mitotane-related hypercholesterolemia that cannot be managed with conventional lipid-lowering treatment. Read More

    Role of Endoscopic Ultrasound-guided Fine-needle Aspiration in Adrenal Lesions: Analysis of 32 Patients.
    J Cytol 2018 Apr-Jun;35(2):83-89
    Department of Pathology, G B Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.
    Objective: Endoscopic ultrasound-guided fine-needle aspiration cytology (EUS-FNAC) is a precise and safe technique that provides both radiological and pathological diagnosis with a better diagnostic yield and minimal adverse events. EUS-FNAC led to the remarkable increase in the detection rate of incidentaloma found during radiologic staging or follow-up in various malignancy or unrelated conditions.

    Aims: We did this preliminary study with an aim to evaluate the role of EUS-FNA in diagnosing and classifying adrenal lesions, clinical impact, and compare the outcome with the previously published literature. Read More

    The Spectrum of Thyroid Gland Pathology in Carney Complex: The Importance of Follicular Carcinoma.
    Am J Surg Pathol 2018 May;42(5):587-594
    Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
    The initial description of Carney complex (CNC) in 1985 included myxomas, spotty skin pigmentation, and endocrine overactivity (of the adrenal, the pituitary, and the testis). In 1997, thyroid neoplasms were found in 3 patients with CNC and involvement of the gland in the syndrome was apparent. Herein, we describe the clinical, pathologic, and follow-up findings in 26 patients with CNC and a disorder of the thyroid gland. Read More

    Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics.
    J Vis Exp 2018 Mar 26(133). Epub 2018 Mar 26.
    Department of Surgery & Yale Endocrine Neoplasia Laboratory, Yale University School of Medicine;
    The cell membrane's extension repertoire modulates various malignant behaviors of cancer cells, including their adhesive and migratory potentials. The ability to accurately classify and quantify cell extensions and measure the effect on a cell's adhesive capacity is critical to determining how cell-signaling events impact cancer cell behavior and aggressiveness. Here, we describe the in vitro design and use of a cell extension quantification method in conjunction with an adhesion capacity assay in an established in vitro model for adrenocortical carcinoma (ACC). Read More

    Cushing's Syndrome: A Historic Review of the Treatment Strategies and Corresponding Outcomes in a Single Tertiary Center over the Past Half-Century.
    Horm Metab Res 2018 Apr 5;50(4):280-289. Epub 2018 Apr 5.
    Clinical Center of Endocrinology and Gerontology, Medical University, Sofia, Bulgaria.
    Cushing's syndrome (CS) is associated with serious comorbidities and an increased mortality rate that could be reduced only if strict biochemical control is achieved. The aim of this study was to show the 50-year experience of a single tertiary center in the management of CS patients - the different treatment modalities used over the years and the corresponding outcomes. It was a retrospective study of a large cohort of patients from the Bulgarian CS database: 613 patients (374 with ACTH-dependent and 239 with ACTH-independent CS). Read More

    Pedigree analysis, diagnosis and treatment in Von Hippel-Lindau syndrome: A report of three cases.
    Oncol Lett 2018 Apr 5;15(4):4882-4890. Epub 2018 Feb 5.
    Department of Urology, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou 563000, P.R. China.
    The objective of the present study was to systematically investigate the clinical features, diagnosis and therapeutic treatment of Von Hippel-Lindau (VHL) syndrome in order to improve understanding of this disease. A total of 3 cases of VHL syndrome treated at the Affiliated Hospital of Zunyi Medical College (Zunyi, China) between September 2014 and October 2015 were retrospectively analyzed. The associated literature was reviewed, and the diagnostic and therapeutic features were discussed. Read More

    Adrenal gland tumors in dairy cattle from Northern Italy: morphological and phenotypical characterization in comparison with human pathology.
    Pol J Vet Sci 2017 Dec;20(4):779-788
    Department of Oncology, San Luigi Hospital, University of Torino, Orbassano, Torino, Italy.
    Bovine adrenal gland tumours are considered relatively common, although scarce data are available about their real incidence, pathological characterization, classification criteria and immunohistochemical profile. This study describes the morphological and immunophenotypical characteristics of 35 dairy cattle adrenal gland tumors from Northern Italy and compare them with human pathology. Macroscopical, histological, histochemical and immunohistochemical investigations were performed. Read More

    Results of adrenalectomy in lung cancer metastases.
    Actas Urol Esp 2018 Mar 30. Epub 2018 Mar 30.
    Servicio de Urología, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, España.
    Background: The aim of this study was to report our centre's experience over the past 15 years with patients with lung carcinoma and adrenal metastases treated sequentially with lung resection and adrenalectomy.

    Patients And Methods: We analysed a retrospective series of 19 patients who underwent adrenalectomy for lung carcinoma metastasis. All patients were operated on at the same centre, between October 2000 and October 2015. Read More

    Open adrenalectomy versus laparoscopic adrenalectomy for adrenocortical carcinoma: a retrospective comparative study on short-term oncologic prognosis.
    Onco Targets Ther 2018 21;11:1625-1632. Epub 2018 Mar 21.
    Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Purpose: Open adrenalectomy (OA) remains the gold standard of surgical therapy for adrenocortical carcinoma, while the role of laparoscopic approach is controversial. We aim to explore the influence of surgical approaches on the oncologic prognosis of adrenocortical carcinoma by comparing the short-term outcomes of patients undergoing OA with those undergoing laparoscopic adrenalectomy (LA).

    Patients And Methods: We retrospectively analyzed the baseline characteristics, perioperative data and short-term prognosis of 42 patients diagnosed with stage I-III adrenocortical carcinoma, receiving OA (n=22) and LA (n=20) as primary therapy. Read More

    Silencing of MED27 inhibits adrenal cortical carcinogenesis by targeting the Wnt/β-catenin signaling pathway and the epithelial-mesenchymal transition process.
    Biol Chem 2017 Dec 20. Epub 2017 Dec 20.
    3Department of Urology, Shanghai Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, No. 197, Ruijin Er Road, Shanghai 200025, China.
    This study aimed to explore the effect of MED27 on the expression of epithelial-mesenchymal transition (EMT)-related proteins and β-catenin in adrenal cortex carcinoma (ACC). The functional mechanism of MED27 on ACC processes was also explored. The expression of MED27 was assessed by quantitative real-time polymerase chain reaction (qRT-PCR). Read More

    Unusual cardiac paraganglioma mimicking an atypical carcinoid tumor of the lung.
    J Thorac Dis 2018 Jan;10(1):E31-E37
    Department of Surgery, Division of Cardiothoracic Surgery, University of California Irvine, Irvine, CA, USA.
    We present a case of unusual cardiac paraganglioma (PG) initially misdiagnosed as atypical carcinoid tumor of the lung and discuss key clinical and pathologic characteristics that guide surgical management of these rare chromaffin cell tumors. A 64-year-old female with persistent cough and back pain was found to have a 4 cm × 3 cm mass abutting multiple cardiopulmonary structures. A biopsy was performed at an outside institution and pathology reported "atypical neuroendocrine carcinoma, consistent with carcinoid". Read More

    Metastatic pheochromocytoma in MEN 2A: A rare association.
    BMJ Case Rep 2018 Mar 28;2018. Epub 2018 Mar 28.
    Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    A 45-year-old woman was diagnosed as having multiple endocrine neoplasia type 2A in 2014. She had bilateral pheochromocytoma, medullary thyroid carcinoma and biopsy-proven cutaneous lichen amyloidosis in the interscapular area. She underwent bilateral adrenalectomy; following which, she achieved clinical and biochemical remission. Read More

    Spontaneous adrenocorticotropic hormone (ACTH) normalisation due to tumour regression induced by metyrapone in a patient with ectopic ACTH syndrome: case report and literature review.
    BMC Endocr Disord 2018 Mar 27;18(1):19. Epub 2018 Mar 27.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Aichi Medical University, School of Medicine, Nagakute, Japan.
    Background: Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is caused by tumours releasing ACTH. Ectopic ACTH-producing tumour regression is rarely induced using steroidogenesis inhibitors. We presented a case of EAS in which ACTH production by a lung tumour was reduced by metyrapone (MTP) and also reviewed previous cases of ectopic ACTH production suppressed via steroidogenesis inhibition. Read More

    Detailed genomic characterization identifies high heterogeneity and histotype-specific genomic profiles in adrenocortical carcinomas.
    Mod Pathol 2018 Mar 26. Epub 2018 Mar 26.
    Department of Oncology, University of Turin at Molinette Hospital, Turin, Italy.
    Molecular characterization of adrenocortical carcinoma has been recently established, but the correlation between molecular profiles and clinical and pathological characteristics is still poorly defined with no data available about genetic heterogeneity along disease progression. In this scenario, a detailed molecular profile was correlated with clinical and pathological characteristics in adrenocortical carcinoma patients to identify potentially novel biomarkers. Targeted next-generation sequencing and copy number variation analyses for 18 most frequently altered genes in adrenocortical carcinoma were assessed on 62 adult cases (including 10 with matched primary and metastatic/recurrence samples) and results correlated with major clinical and pathological characteristics of tumors. Read More

    Prostate-Specific Membrane Antigen Expression in Adrenocortical Carcinoma on 68Ga-Prostate-Specific Membrane Antigen PET/CT.
    Clin Nucl Med 2018 Mar 24. Epub 2018 Mar 24.
    We present here a case of metastatic adrenocortical carcinoma with bilateral lung nodules. The patient had been treated with mitotane therapy initially and then was later referred for chemotherapy. There was progression of disease noted on the F-FDG PET/CT. Read More

    Factors related to improved clinical outcomes associated with adrenalectomy for metachronous adrenal metastases from solid primary carcinomas.
    Surg Oncol 2018 Mar 21;27(1):18-22. Epub 2017 Nov 21.
    Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
    Background: Surgery for metachronous adrenal metastases from solid primary carcinoma has increased with the development of technical skills. Here we analyzed the postoperative clinical outcomes of patients who underwent adrenalectomy for metachronous adrenal metastases from solid primary carcinomas.

    Methods: Patients who underwent adrenalectomy for metachronous adrenal metastases after initial treatment of primary carcinoma at Asan Medical Center from 2000 to 2010 were included. Read More

    Organotin exposure stimulates steroidogenesis in H295R Cell via cAMP pathway.
    Ecotoxicol Environ Saf 2018 Jul 20;156:148-153. Epub 2018 Mar 20.
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
    Organotin compounds (OTs) are used in a range of industrial products, such as antifouling paints, agricultural pesticides and stabilizers. Owing to potential endocrine-disrupting effects, human exposure to such compounds is a concern. Nevertheless, little is known about the adverse effect of OTs on adrenocortical function in organisms. Read More

    Immunohistochemical Biomarkers of Adrenal Cortical Neoplasms.
    Endocr Pathol 2018 Mar 14. Epub 2018 Mar 14.
    Department of Oncology, University of Turin at San Luigi Hospital, Turin University, Orbassano, Turin, Italy.
    Careful morphological evaluation forms the basis of the workup of an adrenal cortical neoplasm. However, the adoption of immunohistochemical biomarkers has added tremendous value to enhance diagnostic accuracy. The authors provide a brief review of immunohistochemical biomarkers that have been used in the confirmation of adrenal cortical origin and in the detection of the source of functional adrenal cortical proliferations, as well as diagnostic, predictive, and prognostic biomarkers of adrenal cortical carcinoma. Read More

    Nutlin-3a as a novel anticancer agent for adrenocortical carcinoma with CTNNB1 mutation.
    Cancer Med 2018 Apr 13;7(4):1440-1449. Epub 2018 Mar 13.
    Department of Urology, Huashan Hospital, Shanghai, 200040, China.
    Adrenocortical carcinoma (ACC) is a rare malignancy, and CTNNB1 is frequently mutated in ACC. Our study aims to screen for effective agents with antineoplastic activity against ACC with CTNNB1 mutation. In-silico screening of the Genomics of Drug Sensitivity in Cancer (GDSC) database was conducted. Read More

    Autophagy as a compensation mechanism participates in ethanol-induced fetal adrenal dysfunction in female rats.
    Toxicol Appl Pharmacol 2018 Apr 7;345:36-47. Epub 2018 Mar 7.
    Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disorder, Wuhan 430071, China. Electronic address:
    Autophagy plays a vital role in embryonic development and cell differentiation. Our previous study demonstrated that prenatal ethanol exposure (PEE) resulted in intrauterine growth retardation (IUGR) and adrenal developmental toxicities in rat offspring. The present study focused on PEE-induced autophagy as an underlying mechanism and its biological significance in female fetal rats. Read More

    MANAGEMENT OF ENDOCRINE DISEASE: Management of Cushing's syndrome during Pregnancy: solved and unsolved questions.
    Eur J Endocrinol 2018 Mar 9. Epub 2018 Mar 9.
    F Castinetti, Department of endocrinology, Aix-Marseille université, Assistance-Publique-Hôpitaux de Marseille, centre de référence des maladies rares d'origine hypophysaire, Marseille, 13005, France.
    With fewer than 200 reported cases, Cushing's syndrome (CS) in pregnancy remains a diagnostic and therapeutic challenge. In normal pregnancies, misleading signs may be observed such as striae or hypokalemia, while plasma cortisol and urinary free cortisol may rise up to 2-3-fold. While the dexamethasone suppression test is difficult to use, reference values for salivary cortisol appear valid. Read More

    TCF21/POD-1, a Transcritional Regulator of SF-1/NR5A1, as a Potential Prognosis Marker in Adult and Pediatric Adrenocortical Tumors.
    Front Endocrinol (Lausanne) 2018 22;9:38. Epub 2018 Feb 22.
    Department of Anatomy, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil.
    With recent progress in understanding the pathogenesis of adrenocortical tumors (ACTs), identification of molecular markers to predict their prognosis has become possible. Transcription factor 21 (TCF21)/podocyte-expressed 1 (POD1) is a transcriptional regulatory protein expressed in mesenchymal cells at sites of epithelial-mesenchymal transition during the development of different systems. Adult carcinomas express less than adenomas, in addition, the KEGG pathway analysis has shown that , among others genes, is negatively correlated with expression. Read More

    MiR-483-5p and miR-139-5p promote aggressiveness by targeting N-myc downstream-regulated gene family members in adrenocortical cancer.
    Int J Cancer 2018 Mar 8. Epub 2018 Mar 8.
    Institut National de la Santé et de la Recherche Médicale, Unité 1036, Grenoble, France.
    Adrenocortical carcinoma (ACC) is a tumor with poor prognosis in which overexpression of a panel of microRNAs has been associated with malignancy but a very limited number of investigations on their role in ACC pathogenesis have been conducted. We examined the involvement of miR-483-5p and miR-139-5p in adrenocortical cancer aggressiveness. Using bioinformatics predictions and mRNA/miRNA expression profiles, we performed an integrated analysis to identify inversely correlated miRNA-mRNA pairs in ACC. Read More

    Time-dependent change in relapse sites of renal cell carcinoma after curative surgery.
    Clin Exp Metastasis 2018 Mar 7. Epub 2018 Mar 7.
    Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
    We investigated time-dependent changes in the relapse features of renal cell carcinoma (RCC) after curative surgery. Between 1985 and 2015, 1398 patients with RCC (1226 clear cell RCC, 89 papillary RCC, and 53 chromophobe RCC) underwent curative surgery at Yokohama City University Hospital and its affiliated hospitals. We retrospectively reviewed the clinicopathologic factors of patients with relapse after surgery. Read More

    The Expression and Prognostic Impact of Immune Cytolytic Activity-Related Markers in Human Malignancies: A Comprehensive Meta-analysis.
    Front Oncol 2018 21;8:27. Epub 2018 Feb 21.
    Department of Life Sciences, Biomedical Sciences Program, School of Sciences, European University Cyprus, Nicosia, Cyprus.
    Background: Recently, immune-checkpoint blockade has shown striking clinical results in different cancer patients. However, a significant inter-individual and inter-tumor variability exists among different cancers. The expression of the toxins granzyme A (GZMA) and perforin 1 (PRF1), secreted by effector cytotoxic T cells and natural killer (NK) cells, were recently used as a denominator of the intratumoral immune cytolytic activity (CYT). Read More

    Skeletal metastasis in renal cell carcinoma: A review.
    Ann Med Surg (Lond) 2018 Mar 31;27:9-16. Epub 2018 Jan 31.
    Aga Khan University Hospital Karachi, Pakistan.
    Background: Renal cell carcinoma account for 3% of all cancers, with peak incidence between 60 and 70 years of age predominantly affecting male population. Renal carcinoma is the most common malignancy of kidney constitutes for 80-90% of renal neoplasm with an overall 45% five years survival rate. Majority are diagnosed incidentally during investigation for other disease process of abdomen. Read More

    The tyrosine kinase inhibitor nilotinib is more efficient than mitotane in decreasing cell viability in spheroids prepared from adrenocortical carcinoma cells.
    Cancer Cell Int 2018 1;18:29. Epub 2018 Mar 1.
    Department of Anatomy, Institute of Biomedical Science, University of São Paulo, São Paulo, SP Brazil.
    Background: New drugs for adrenocortical carcinoma (ACC) are needed because most patients undergo rapid disease progression despite surgery and adjuvant therapy with mitotane. In this study, we aimed to investigate the in vitro effects of different chemotherapy drugs, alone or combined with mitotane, on the viability of adrenocortical carcinoma cells.

    Methods: Everolimus, sunitinib, zoledronic acid, imatinib and nilotinib cytotoxicity, alone or combined with mitotane were tested on ACC H295R cells in monolayer or spheroid cultures using MTS assays and confocal microscopy. Read More

    A case of adrenocortical carcinoma accompanying secondary acute adrenal hypofunction postoperation.
    World J Surg Oncol 2018 Mar 5;16(1):43. Epub 2018 Mar 5.
    Department of Hepatobiliary and Pancreatic Surgery, Bethune Hospital 1, Changchun, Jilin, 130021, China.
    Background: Adrenocortical carcinoma (ACC) is a rare, heterogeneous malignancy with a poor prognosis. ACCs are classified as functioning and non-functioning. The pathogenesis of ACC remains elusive, and diagnosis of ACC is currently based on pathology. Read More

    Two-stage resection of a bilateral pheochromocytoma and pancreatic neuroendocrine tumor in a patient with von Hippel-Lindau disease: A case report.
    Int J Surg Case Rep 2018 16;44:139-142. Epub 2018 Feb 16.
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
    Introduction: von Hippel-Lindau disease (vHL disease) is a hereditary disease in which tumors and cysts develop in many organs, in association with central nervous system hemangioblastomas, pheochromocytomas, and pancreatic tumors. We herein report a case of vHL disease (type 2A) associated with bilateral pheochromocytomas, pancreatic neuroendocrine tumors (PNET), and cerebellar hemangioblastomas treated via pancreatectomy after adrenalectomy.

    Case Presentation: A 51-year-old woman presented with a cerebellar tumor, bilateral hypernephroma, and pancreatic tumor detected during a medical checkup. Read More

    Impact of Micro- and Macroscopically Positive Surgical Margins on Survival after Resection of Adrenocortical Carcinoma.
    Ann Surg Oncol 2018 May 2;25(5):1425-1431. Epub 2018 Mar 2.
    Duke University School of Medicine, Durham, NC, USA.
    Purpose: Adrenocortical carcinoma (ACC) is a rare, aggressive cancer; complete surgical resection offers the best chance for long-term survival. The impact of surgical margin status on survival is poorly understood. Our objective was to determine the association of margin status with survival. Read More

    A black adrenal adenoma with high FDG uptake on PET/CT scan in a patient with esophageal carcinoma: A case report.
    Int J Surg Case Rep 2018 7;44:118-121. Epub 2017 Dec 7.
    Department of Surgery, Jichi Medical University, Tochigi, Japan.
    Introduction: Black adrenal adenoma (BAA) is a rare, benign adrenal lesion with a black or brown appearance. This is the first report of this lesion in a patient with a synchronous esophageal cancer and highlights the importance of considering a false positive finding on a Positron Emission Tomography (PET) scan, which might otherwise preclude resection.

    Presentation Of Case: A 73-year-old male was diagnosed with mid-esophagus carcinoma. Read More

    Primary carcinosarcoma of the liver: imaging features and clinical findings in six cases and a review of the literature.
    Cancer Imaging 2018 Feb 27;18(1). Epub 2018 Feb 27.
    Department of Radiology, the First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, Henan, 450052, China.
    Background: Carcinosarcoma of the liver is a very rare tumor composed of a mixture of carcinomatous and sarcomatous elements. Less than 25 adequately documented cases have been reported, with inadequate description of imaging features. In order to improve the awareness of this rare tumor, this study aimed to analyze the clinicopathologic and imaging features of six cases of hepatic carcinosarcoma (HCS) confirmed by surgical pathologic evaluation. Read More

    MANAGEMENT OF ENDOCRINE DISEASE: Adrenocortical carcinoma: differentiating the good from the poor prognosis tumors.
    Eur J Endocrinol 2018 May 23;178(5):R215-R230. Epub 2018 Feb 23.
    Institut CochinINSERM U1016, CNRS UMR8104, Paris Descartes University, Paris, France
    Adrenocortical carcinoma (ACC) is a rare malignancy with a poor prognosis, the five-years overall survival being below 40%. However, there is great variability of outcomes and we have now a better view of the heterogeneity of tumor aggressiveness. The extent of the disease at the time of diagnosis, best assayed by the European Network for the Study of Adrenal Tumors (ENSAT) Staging Score, is a major determinant of survival. Read More

    The GRP78/BiP inhibitor HA15 synergizes with mitotane action against adrenocortical carcinoma cells through convergent activation of ER stress pathways.
    Mol Cell Endocrinol 2018 Feb 20. Epub 2018 Feb 20.
    Université Côte d'Azur, Valbonne, 06560, France; CNRS UMR 7275, Sophia Antipolis, Valbonne, 06560, France; NEOGENEX CNRS International Associated Laboratory, Valbonne, 06560, France; Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, 06560, France. Electronic address:
    Many types of cancer cells present constitutively activated ER stress pathways because of their significant burden of misfolded proteins coded by mutated and rearranged genes. Further increase of ER stress by pharmacological intervention may shift the balance towards cell death and can be exploited therapeutically. Recent studies have shown that an important component in the mechanism of action of mitotane, the only approved drug for the medical treatment of adrenocortical carcinoma (ACC), is represented by activation of ER stress through inhibition of the SOAT1 enzyme and accumulation of toxic lipids. Read More

    Yttrium-90 microsphere selective internal radiation therapy for liver metastases following systemic chemotherapy and surgical resection for metastatic adrenocortical carcinoma.
    World J Clin Oncol 2018 Feb;9(1):20-25
    Division of Vascular and Interventional Radiology, Department of Radiology, the Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, United States.
    Adrenocortical carcinoma (ACC) is a rare malignancy with generally poor outcomes and limited treatment options. While surgical resection can be curative for early local disease, most patients present with advanced ACC owing to nonspecific symptoms. For those patients, treatment options include systemic chemotherapy and locoregional therapies including radiofrequency ablation and transarterial chemoembolization. Read More

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