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    Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma.
    J Med Chem 2017 Oct 16. Epub 2017 Oct 16.
    Novartis Institutes for BioMedical Research, Inc. , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139-4133, United States.
    Herein we describe the discovery and characterization of a novel, piperidine-based inhibitor of cholesteryl ester transfer protein (CETP) with a core structure distinct from other reported CETP inhibitors. A versatile synthesis starting from 4-methoxypyridine enabled an efficient exploration of the SAR, giving a lead molecule with potent CETP inhibition in human plasma. The subsequent optimization focused on improvement of pharmacokinetics and mitigation of off-target liabilities, such as CYP inhibition, whose improvement correlated with increased lipophilic efficiency. Read More

    Intraparenchymal Hemorrhage due to Brain Metastasis of Hepatocellular Carcinoma.
    Case Rep Gastroenterol 2017 Sep-Dec;11(3):516-525. Epub 2017 Sep 13.
    Faculty of Medicine, Universidade de Caxias do Sul, Caxias do Sul, Brazil.
    Although extrahepatic metastases from hepatocellular carcinoma (HCC) are present in only 5-15% of cases, they are certainly factors associated with poor prognosis. The main sites include lung, lymph nodes, bones, and adrenal glands, in descending order. Metastasis in the central nervous system is extremely rare, and the incidences vary from 0. Read More

    New insights in the clinical and translational relevance of miR483-5p in adrenocortical cancer.
    Oncotarget 2017 Sep 10;8(39):65525-65533. Epub 2017 Jul 10.
    Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
    Adrenocortical cancer (ACC) is a rare aggressive malignancy. Recent ACC integrated genomics analysis contributed to redefine the risk groups on molecular basis, including tumor microRNAs (miRs), detectable also in the bloodstream. We developed a quantitative real-time (RT) assay for the measurement of miR483 and miR483-5p absolute levels in plasma samples. Read More

    Advances in understanding the molecular underpinnings of adrenocortical tumors.
    Curr Opin Oncol 2017 Oct 11. Epub 2017 Oct 11.
    Section of Endocrine Surgery, Yale Endocrine Neoplasia Laboratory, Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA.
    Purpose Of Review: Adrenocortical tumors are divided into benign adenomas and malignant carcinomas. The former is relatively common and carries a favorable prognosis, whereas the latter is rare and frequently presents at an advanced stage, with poor outcomes. Advances in next-generation sequencing, genome analysis, and bioinformatics have allowed for high-throughput molecular characterization of adrenal tumorigenesis. Read More

    Chromogranin A as a Biochemical Marker for Neuroendocrine Tumors: A Single Center Experience at Royal Hospital, Oman.
    Oman Med J 2017 Sep;32(5):365-370
    Department of Chemical Pathology, Directorate of Laboratory Medicine and Pathology, Royal Hospital, Muscat, Oman.
    Objectives: To evaluate the significance of serum chromogranin A (CgA) status in patients with and without different neuroendocrine tumors (NETs) by conducting a retrospective assessment of the diagnostic utility and limitations of CgA as a biomarker for NETs in a tertiary care hospital in Oman.

    Methods: We conducted a retrospective analysis of CgA requests referred to the Clinical Biochemistry Laboratory, Royal Hospital, Oman over a 24-month period (April 2012 to March 2014). During this time, 302 CgA tests for 270 patients (119 males and 151 females; age range 11-86 years and mean±standard deviation (SD) 44. Read More

    Minimally Invasive Adrenalectomy for Adrenocortical Carcinoma: Five-Year Trends and Predictors of Conversion.
    World J Surg 2017 Oct 11. Epub 2017 Oct 11.
    Department of Surgery, NorthShore University HealthSystem, 2650 Ridge Avenue, Walgreen Suite 2507, Evanston, IL, 60201, USA.
    Background: Adrenocortical carcinoma (ACC) is rare but often fatal. Surgery offers the only chance of cure. As minimally invasive (MI) procedures for cancer become common, their role for ACC is still debated. Read More

    Adding metyrapone to chemotherapy plus mitotane for Cushing's syndrome due to advanced adrenocortical carcinoma.
    Endocrine 2017 Oct 10. Epub 2017 Oct 10.
    Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy.

    Diagnosis of Adrenocortical Tumors by Reticulin Algorithm.
    Indian J Endocrinol Metab 2017 Sep-Oct;21(5):734-737
    Department of Pathology and Laboratory Medicine, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.
    Aims: To apply reticulin algorithm (RA) to the diagnosis of adrenocortical tumors on adrenalectomy specimens and compare its efficacy to the modified Weiss criteria or Lin-Weiss-Bisceglia (LWB) criteria for oncocytic variant.

    Materials And Methods: Adrenocortical tumors (ACTs) diagnosed on resected specimens including the variants during January 2010-June 2016 were retrieved from the pathology records. The demographic and clinical data were obtained from medical records. Read More

    Robotic Radical Left Nephrectomy With Inferior Vena Cava Level III Thrombectomy.
    Urology 2017 Sep 5;107:269. Epub 2017 May 5.
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH. Electronic address:
    Introduction And Objective: We present our robotic approach and technique to manage a large left renal tumor with inferior vena cava (IVC) Level III thrombus. The superior mesenteric artery crossing the left renal vein requires robotic docking from the left, for dissection of the left kidney followed by repositioning and re-docking the robot from the right side for dissection of the right renal vein, distal and proximal IVC, and the remaining left renal vein insertion into the IVC.

    Methods: We present a 53-year-old man with a 10. Read More

    Robotic-assisted Thoracoscopic Transdiaphragmatic Adrenalectomy (RATTA) for Metastatic Renal Cell Carcinoma.
    Urology 2017 Jul 31;105:9-12. Epub 2017 Mar 31.
    Department of Urology, University of Michigan, Ann Arbor, MI. Electronic address:
    Objective: Robotic-assisted thoracoscopic transdiaphragmatic adrenalectomy (RATTA) represents a novel surgical approach for the management of adrenal pathology in patients with a history of extensive transperitoneal or retroperitoneal procedures.

    Methods: Here we report the first described case of RATTA in a 56-year-old woman with metastatic renal cell carcinoma to the left adrenal gland and right lung. With the assistance of cardiothoracic surgery, this patient underwent robotic-assisted thoracoscopic pulmonary wedge resection and RATTA. Read More

    [Adrenal disease diagnosis: management of adrenal incidentaloma].
    Rev Med Brux 2017 ;38(4):325-333
    Service d'Endocrinologie, Hôpital Erasme, ULB.
    Adrenal glands are specialized in biosynthesis of several hormones correlated to different clinical phenotypes in case of excess or lack of production. In addition to secretion disorders, tumors, secreting or not, can take place in adrenal glands. Incidentalomas are the most common adrenal diseases in clinical practice. Read More

    Case report of (18) F-fluorodeoxyglucose positron emission tomography-computed tomography imaging of a patient with multiple endocrine gland metastases from small cell lung cancer.
    Thorac Cancer 2017 Oct 5. Epub 2017 Oct 5.
    Neurosurgery Department, The First Hospital of Jilin University, Changchun, China.
    Synchronous multiple endocrine gland metastasis caused by small cell lung cancer (SCLC) is rare. A patient was investigated for primary cancer because of suspected brain metastasis on computed tomography (CT). Baseline (18) F-fluorodeoxyglucose (FDG) positron emission tomography (PET)-CT was positive in the lung and multiple endocrine glands (right thyroid, right breast, pancreatic body, right adrenal gland, and left ovary). Read More

    Identification of mutations in Cell-free Circulating Tumor DNA in Adrenocortical Carcinoma: a Case Series.
    J Clin Endocrinol Metab 2017 Jun 30. Epub 2017 Jun 30.
    Departments of Internal Medicine, division of Endocrinology.
    Context: The disease course of adrenocortical carcinoma (ACC) patients is heterogeneous. A marker for prognosis and treatment response would facilitate choices on diagnosis and therapy. In other cancer types, circulating cell-free tumor DNA (ctDNA) predicted tumor dynamics. Read More

    A Phase 1 study of ARQ 087, an oral pan-FGFR inhibitor in patients with advanced solid tumours.
    Br J Cancer 2017 Oct 3. Epub 2017 Oct 3.
    Winship Cancer Institute of Emory University, 1365-C Clifton Road NE, Atlanta, GA 30322, USA.
    Background: ARQ 087 is an orally administered pan-FGFR inhibitor with multi-kinase activity. This Phase 1 study evaluated safety, pharmacokinetics, and pharmacodynamics of ARQ 087 and defined the recommended Phase 2 dose (RP2D).

    Methods: Patients with advanced solid tumours received ARQ 087 administered initially at 25 mg every other day and dose-escalated from 25 to 425 mg daily (QD) continuous dosing. Read More

    Omics AnalySIs System for PRecision Oncology (OASISPRO): A Web-based Omics Analysis Tool for Clinical Phenotype Prediction.
    Bioinformatics 2017 09 12. Epub 2017 Sep 12.
    Department of Genetics, Stanford University, 300 Pasteur Dr., M-344, Stanford, CA 94305-5120.
    Summary: Precision oncology is an approach that accounts for individual differences to guide cancer management. Omics signatures have been shown to predict clinical traits for cancer patients. However, the vast amount of omics information poses an informatics challenge in systematically identifying patterns associated with health outcomes, and no general-purpose data-mining tool exists for physicians, medical researchers, and citizen scientists without significant training in programming and bioinformatics. Read More

    Unilateral adrenal mass as the sole initial manifestation of differentiated thyroid cancer.
    BMJ Case Rep 2017 Sep 27;2017. Epub 2017 Sep 27.
    Department of Endocrinology and Metabolism, Amrita Institute of Medical Sciences and Research Centre, Cochin, Kerala, India.
    Unilateral adrenal metastases without disseminated disease has rarely been reported in differentiated thyroid carcinoma (DTC). A 72-year-old female presented with vague abdominal discomfort and loss of appetite of 2 months duration. She had undergone left hemithyroidectomy for a benign thyroid nodule 18 years ago. Read More

    Radioimmunoassay of chromogranin A and free metanephrines in diagnosis of pheochromocytoma.
    Physiol Res 2017 Sep;66(Supplementum 3):S397-S408
    Institute of Endocrinology, Prague, Czech Republic.
    This work discusses the clinical performance of chromogranin A, free metanephrine and normetanephrine determination in plasma using a radioimmunoanalytical methods for the diagnosis of pheochromocytoma and paraganglioma. Blood samples were collected from 55 patients (46 pheochromocytomas, 9 paragangliomas). A sampling of biological materials was performed preoperatively and about one week, six months and one year after adrenal gland surgery. Read More

    Small Non-coding RNA Abundance in Adrenocortical Carcinoma: A Footprint of a Rare Cancer.
    J Genomics 2017 8;5:99-118. Epub 2017 Sep 8.
    Division of Plastic Surgery, Department of Surgery, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
    BACKGROUND: Adrenocortical carcinoma (ACC) is a relatively rare, but aggressive type of cancer, which affects both children and adults. OBJECTIVE: Small non-coding RNAs (sncRNAs) play important roles and may serve as biomarkers for disease diagnosis, prognosis and treatment. METHODS: In our study, we sought to identify sncRNAs associated with malignant adrenal tumors. Read More

    Leptomeningeal metastasis of pulmonary large-cell neuroendocrine carcinoma: A case report and review of the literature.
    Oncol Lett 2017 Oct 26;14(4):4282-4286. Epub 2017 Jul 26.
    Department of Radiation-Oncology, Tumor Hospital of Jilin, Changchun, Jilin 130000, P.R. China.
    Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare and malignant form of lung cancer with a poor prognosis for patients. The common sites of metastases are the liver, adrenal glands, bone and brain. LCNEC rarely metastasizes to the small intestine, ovaries, tonsils, mandible, vulva or spine. Read More

    Ectopic, retroperitoneal adrenocortical carcinoma in the setting of Lynch syndrome.
    Fam Cancer 2017 Sep 22. Epub 2017 Sep 22.
    Division of Surgical Oncology, Department of Surgery, Vanderbilt University Medical Center, 2220 Pierce Avenue, Nashville, TN, 37232-2391, USA.
    Adrenocortical carcinoma (ACC) is rare within the adult population. Ectopic ACC proves even rarer. This variant is formed by cortical fragments arrested during embryologic migration. Read More

    [One Case about Primary Pulmonary Squamous Cell Carcinoma 
with Retinal Metastasis].
    Zhongguo Fei Ai Za Zhi 2017 Sep;20(9):652-656
    Department of Nephrosis Internal Medicine, the First Hospital of Jilin University, Changchun 130000, China.
    Lung cancer is a common malignant tumor in clinic. Morbidity and mortality are the first place in cancer, which seriously threaten the health of human beings. Due to the lack of effective and specific screening methods, most patients were found already at an advanced stage, and often combined with bone, brain, liver, adrenal and other parts of the metastasis. Read More

    Small cell neuroendocrine carcinoma of the paranasal sinus with intraoral involvement: Report of a rare case and review of the literature.
    J Oral Maxillofac Pathol 2017 May-Aug;21(2):286-295
    Department of Oral and Maxillofacial Pathology, Goa Dental College and Hospital, Bambolim, Goa, India.
    The diffuse neuroendocrine system continues to be an enigmatic topic of study in pathology due to its controversial embryologic origins, biology and a variety of tumors engendered. Originally thought to be localized to the classic neuroendocrine organs (pituitary, thyroid, pancreas and adrenal medulla), the neuroendocrine cells are now known to be distributed in every organ system of the body. A number of human diseases have been linked to aberrations in the functioning of the neuroendocrine cells. Read More

    Management of Incidental Liver Lesions on CT: A White Paper of the ACR Incidental Findings Committee.
    J Am Coll Radiol 2017 Sep 16. Epub 2017 Sep 16.
    Department of Radiology, Institute for Technology Assessment, Massachusetts General Hospital, Boston, Massachusetts.
    The ACR Committee on Incidental Findings presents recommendations for managing liver lesions that are incidentally detected on CT. These recommendations represent an update from the liver component of the ACR 2010 white paper on managing incidental findings in the pancreas, adrenal glands, kidneys, and liver. The Liver Subcommittee-which included five abdominal radiologists, one hepatologist, and one hepatobiliary surgeon-developed this algorithm. Read More

    Local Control and Survival after Image-Guided Percutaneous Ablation of Adrenal Metastases.
    J Vasc Interv Radiol 2017 Sep 16. Epub 2017 Sep 16.
    Division of Interventional Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
    Purpose: To evaluate local control and survival after image-guided ablation of adrenal gland metastases.

    Materials And Methods: Image-guided ablations of adrenal metastases measuring < 5 cm performed at 2 academic medical centers between July 2002 and June 2016 were analyzed. There were 51 procedures performed on 46 tumors (mean diameter 2. Read More

    Recurrent Metastatic Medullary Thyroid Carcinoma: A Case of Sustained Response to Prolonged Treatment with Somatostatin Analogues.
    Thyroid 2017 Sep 19. Epub 2017 Sep 19.
    General Hospital of Ciudad Real, Medical Oncology, Ciudad Real, Spain ;
    Background: Medullary thyroid carcinoma (MTC) is a rare disease. Treatment options for recurrent disease are limited. Somatostatin analogues might have a role as anticancer agents agents in MTC, although the evidence is inconclusive. Read More

    Screening for primary aldosteronism using the newly developed IDS-iSYS® automated assay system.
    Pract Lab Med 2017 Apr 13;7:6-14. Epub 2016 Nov 13.
    Department of Clinical Biochemistry & Diagnostic Endocrinology, Mater Misericordiae University Hospital, Dublin, Ireland.
    Background: The recommended approach to screening for primary aldosteronism (PA) in at-risk populations is to determine the ratio of aldosterone concentration (serum (SAC)/plasma (PAC)) to renin measured in plasma as activity (PRA) or concentration (DRC). However, lack of assay standardisation mandates the need for method-specific decision thresholds and clinical validation in the local population.

    Aim: The study objective was to establish method-specific aldosterone: renin ratio (ARR) cut-offs for PA in men and women using the IDS-iSYS® assay system (IDS plc). Read More

    Synthetic high-density lipoprotein nanodisks for targeted withalongolide delivery to adrenocortical carcinoma.
    Int J Nanomedicine 2017 6;12:6581-6594. Epub 2017 Sep 6.
    Department of Pharmaceutical Sciences, College of Pharmacy.
    Adrenocortical carcinoma (ACC) is a rare endocrine malignancy and has a 5-year survival rate of <35%. ACC cells require cholesterol for steroid hormone production, and this requirement is met via expression on the cell surface of a high level of SRB1, responsible for the uptake of high-density lipoproteins (HDLs), which carry and transport cholesterol in vivo. Here, we describe how this natural lipid carrier function of SRB1 can be utilized to improve the tumor-targeted delivery of a novel natural product derivative - withalongolide A 4,19,27-triacetate (WGA-TA) - which has shown potent antitumor efficacy, but poor aqueous solubility. Read More

    Impact of Adrenocortical Insufficiency on Clinical Parameters in Haemodynamically Stable Cirrhotic Patients with Ascites.
    Mymensingh Med J 2017 Jul;26(3):541-544
    Dr Habib Ahmed, Registrar, Department of Gastroenterology, Shaheed Suhrawardy Medical College Hospital, Dhaka, Bangladesh.
    Cirrhosis has many complications regardless of the aetiology. Complications include splenomegaly, ascites, hepatic encephalopathy, spontaneous bacterial peritonitis, hepatorenal syndrome and hepatocellular carcinoma and also linked to abnormalities in the endocrine system, including abnormal sex hormone metabolism, thyroid disease, osteoporosis, and, most recently identified, adrenal insufficiency. This prospective cohort study was done to evaluate the impact of adrenocortical insufficiency on clinical parameters in haemodynamically stable cirrhotic patients with ascites and had been performed at the inpatient of GHPD Department, BIRDEM, Dhaka, Bangladesh from April 2011 to March 2012. Read More

    Stereotactic body radiotherapy for primary renal cell carcinoma and adrenal metastases.
    Chin Clin Oncol 2017 Sep;6(Suppl 2):S17
    Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
    The incidence of renal cell carcinoma (RCC) and metastatic adrenal lesions continues to rise and present evolving complexities in terms of management. Technical challenges in treatment delivery are compounded by the setting of an ageing patient population with multiple medical co-morbidities. While the standard of care treatment for both primary RCC and oligometastatic adrenal lesions has typically been surgery, a number of patients may be medically or surgically inoperable, and for whom alternative options require consideration. Read More

    Impact of etiology, age and gender on onset and severity of hyponatremia in patients with hypopituitarism: retrospective analysis in a specialised endocrine unit.
    Endocrine 2017 Sep 14. Epub 2017 Sep 14.
    Department of Neuroendocrinology, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia.
    Background: Hyponatremia can unmask hypopituitarism and secondary adrenal insufficiency. This is important, since the need to screen for steroid deficiency, in patients with hyponatremia is often neglected.

    Patients And Methods: In a retrospective study, twenty-five patients (13f/12m, age 58. Read More

    Assessment of VAV2 Expression Refines Prognostic Prediction in Adrenocortical Carcinoma.
    J Clin Endocrinol Metab 2017 Sep;102(9):3491-3498
    Université Côte d'Azur, Sophia Antipolis, 06560 Valbonne, France.
    Context: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with overall poor prognosis. The Ki67 labeling index (LI) has a major prognostic role in localized ACC after complete resection, but its estimates may suffer from considerable intra- and interobserver variability. VAV2 overexpression induced by increased Steroidogenic Factor-1 dosage is an essential factor driving ACC tumor cell invasion. Read More

    Whole-exome analysis of a Li-Fraumeni family trio with a novel TP53 PRD mutation and anticipation profile.
    Carcinogenesis 2017 Sep;38(9):938-943
    FPS - Fondazione Pisana per la Scienza, Pisa 56121, Italy.
    Li-Fraumeni syndrome is a clinically heterogeneous familial cancer predisposition syndrome with autosomal-dominant inheritance caused by heterozygous germline mutations in the TP53 gene. We here analyze the genetic background of a family with a 4-year-proband presented with a Li-Fraumeni tumor. The mother developed breast cancer at age 37 and the proband died at age 8. Read More

    A 13-Steroid Serum Panel Based on LC-MS/MS: Use in Detection of Adrenocortical Carcinoma.
    Clin Chem 2017 Sep 13. Epub 2017 Sep 13.
    Department of Clinical Biochemistry (Viapath), King's College Hospital NHS Foundation Trust, London, UK.
    Background: Adrenocortical carcinoma (ACC) is a rare malignancy, with an annual incidence of 1 or 2 cases per million. Biochemical diagnosis is challenging because up to two-thirds of the carcinomas are biochemically silent, resulting from de facto enzyme deficiencies in steroid hormone biosynthesis. Urine steroid profiling by GC-MS is an effective diagnostic test for ACC because of its capacity to detect and quantify the increased metabolites of steroid pathway synthetic intermediates. Read More

    Supplemental conventional transarterial embolization/chemoembolization therapy via extrahepatic arteries for hepatocellular carcinoma.
    J Cancer Res Ther 2017 ;13(4):720-724
    Department of Radiology, No. 2 People's Hospital of Changzhou, Nanjing Medical University, China.
    Purpose: To assess the value of conventional transarterial embolization/chemoembolization (cTAE/TACE) therapy via extrahepatic arteries for patients with unresectable hepatocellular carcinoma (HCC).

    Methods: Patients with unresectable HCC who underwent cTAE/TACE therapy via extrahepatic arteries between May 2008 and July 2016 across 4 medical centers were identified. The technical success, serum alpha-fetoprotein (AFP) levels changes, tumor response, disease control rate, survival rate, and major complication were analyzed. Read More

    The Impact of Nodal Dissection on Staging in Adrenocortical Carcinoma.
    Ann Surg Oncol 2017 Sep 11. Epub 2017 Sep 11.
    Department of Surgery, New York Presbyterian Hospital - Weill Cornell Medicine, New York, NY, USA.
    Background: The role of lymphadenectomy in adrenocortical carcinoma (ACC) is controversial, and formal lymph node (LN) dissection is not routine. We sought to determine the minimum number of LNs that must be examined to accurately identify a patient as node negative.

    Methods: The National Cancer Database was used to identify patients diagnosed with ACC from 2004 to 2013 who underwent surgical resection. Read More

    Immunotherapy against endocrine malignancies: immune checkpoint inhibitors lead the way.
    Endocr Relat Cancer 2017 Sep 11. Epub 2017 Sep 11.
    L Ward, Laboratory of Cancer Molecular Genetics, University of Campinas (FCM-Unicamp), Faculty of Medical Sciences, Campinas, Brazil
    Immune checkpoint inhibitors are agents that act by inhibiting the mechanisms of immune escape displayed by various cancers. The success of immune checkpoint inhibitors against several tumors has promoted a new treatment strategy in clinical oncology, and this has encouraged physicians to increase the number of patients who receive the immune checkpoint therapy. In the present article, we review the main concepts regarding immune checkpoint mechanisms and how cancer disrupts them to undergo immune escape. Read More

    Is there a role for epithelial-mesenchymal transition in adrenocortical tumors?
    Endocrine 2017 Sep 8. Epub 2017 Sep 8.
    Endocrinology Section, Federal Hospital of Lagoa, Rio de Janeiro, Brazil.
    Purpose: Epithelial-mesenchymal transition (EMT) is a biological dynamic process by which epithelial cells lose their epithelial phenotype and acquire mesenchymal invasive and migratory characteristics. This has been postulated as an essential step during cancer progression and metastasis. Although this is well described in other tumors, the role of EMT in adrenocortical tumors (ACT) has yet to be addressed. Read More

    Laparoscopic adrenalectomy as an effective approach to massive bilateral pheochromocytomas.
    BMJ Case Rep 2017 Sep 7;2017. Epub 2017 Sep 7.
    Department of Endocrinology, Diabetes and Metabolism, Coimbra Hospital and University Centre, Coimbra, Portugal.
    Pheochromocytomas are catecholamine-secreting neoplasms, arising from adrenomedullary chromaffin cells. In type 2 multiple endocrine neoplasia (MEN2) syndrome, pheochromocytomas are usually benign but with predisposition to be bilateral (50%-80% of cases).The authors present the case of a young patient diagnosed with uncommonly large bilateral cystic pheochromocytomas and simultaneous detection of medullary thyroid carcinoma. Read More

    Establishment of a mouse xenograft model of metastatic adrenocortical carcinoma.
    Oncotarget 2017 Aug 7;8(31):51050-51057. Epub 2017 Apr 7.
    Université Côte d'Azur, Valbonne, Sophia Antipolis, France.
    Adrenocortical carcinoma is a rare neoplasm with a poor prognosis. Very important advances have been made in the identification of the genetic determinants of adrenocortical carcinoma pathogenesis but our understanding is still limited about the mechanisms that determine cancer spread and metastasis. One major problem hindering preclinical experimentation for new therapies for adrenocortical carcinoma is represented by the lack of suitable animal models for metastatic disease. Read More

    Complete response in a patient with stage IV adrenocortical carcinoma treated with adjuvant trans-catheter arterial chemo-embolization (TACE).
    Asia Pac J Clin Oncol 2017 Sep 6. Epub 2017 Sep 6.
    Royal North Shore Hospital, Reserve Road, NSW, Australia.
    Adrenocortical carcinoma is a rare cancer, with estimate population incidence of 0.7-2.0 cases per 1 million each year. Read More

    Uncommon Localization of Extrarenal Xp11.2 Translocation-associated Renal Cell Carcinoma (RCC): Case Report.
    Appl Immunohistochem Mol Morphol 2017 Sep 4. Epub 2017 Sep 4.
    *Department of Pathology, Faculty of Medicine †Department of Pathology, Rabigh Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
    The World Health Organization has recognized Xp11.2 translocation-associated renal cell carcinoma (RCC) as a distinct neoplasm that arises within the kidney. Although many reports of extrarenal carcinoma may be found in the literature, to the best of our knowledge, Xp11 translocation-associated RCC with intact kidneys has not been documented. Read More

    Diagnostic and Prognostic Biomarkers of Adrenal Cortical Carcinoma.
    Am J Surg Pathol 2017 Sep 4. Epub 2017 Sep 4.
    *Department of Pathology, University Health Network †Department of Laboratory Medicine and Pathobiology, University of Toronto ‡Endocrine Oncology Site Group, The Princess Margaret Cancer Centre, Toronto, ON, Canada §Department of Pathology, Recep Tayyip Erdogan University, Rize ∥Department of Pathology, Ondokuz Mayis University, Samsun, Turkey.
    The diagnosis of low-grade adrenal cortical carcinoma (ACC) confined to the adrenal gland can be challenging. Although there are diagnostic and prognostic molecular tests for ACC, they remain largely unutilized. We examined the diagnostic and prognostic value of altered reticulin framework and the immunoprofile of biomarkers including IGF-2, proteins involved in cell proliferation and mitotic spindle regulation (Ki67, p53, BUB1B, HURP, NEK2), DNA damage repair (PBK, γ-H2AX), telomere regulation (DAX, ATRX), wnt-signaling pathway (beta-catenin) and PI3K signaling pathway (PTEN, phospho-mTOR) in a tissue microarray of 50 adenomas and 43 carcinomas that were characterized for angioinvasion as defined by strict criteria, Weiss score, and mitotic rate-based tumor grade. Read More

    Adrenocortical carcinoma: patterns of care and role of adjuvant radiation therapy-a population-based study and review of the literature.
    Curr Oncol 2017 Aug 31;24(4):e316-e322. Epub 2017 Aug 31.
    Radiation Medicine Program, The Ottawa Hospital, and.
    Purpose: We reviewed the experience of a tertiary cancer centre in the management of adrenocortical carcinoma (acc) treated over 40 years. We also searched the literature for guidelines related to the treatment of acc and for evidence for adjuvant radiation therapy (rt).

    Methods: In a retrospective chart review, acc patients treated between January 1974 and December 2013 were identified, and patient demographics and tumour characteristics were extracted. Read More

    Secondary Adrenal Insufficiency Following Nivolumab Therapy in a Patient with Metastatic Renal Cell Carcinoma.
    Tokai J Exp Clin Med 2017 Sep 20;42(3):115-120. Epub 2017 Sep 20.
    Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Iseharashi, Kanagawa 259-1193, Japan.
    Currently, nivolumab (an anti-programmed cell death-1 receptor monoclonal antibody) is available for many types of advanced cancers in Japan. However, there have been few detailed case reports about endocrine-related adverse events of this therapy. Here, we report a patient with metastatic renal cell carcinoma who presented with secondary adrenal insufficiency following nivolumab therapy. Read More

    Robot-assisted Extracranial Stereotactic Radiotherapy of Adrenal Metastases in Oligometastatic Non-small Cell Lung Cancer.
    Anticancer Res 2017 09;37(9):5285-5291
    University Hospital of Cologne, Department of Radiation-Oncology, Cologne, Germany.
    Aim: The aim of this study was to evaluate the efficacy and toxicity of stereotactic body radiation therapy (SBRT) in the treatment of patients with adrenal metastases in oligometastatic non-small-cell lung cancer (NSCLC).

    Patients And Methods: Between November 2012 and May 2015, fifteen patients with oligometastatic non-small cell lung cancer and adrenal metastases were treated with the Cyberknife® system. The primary endpoint was local control. Read More

    Solitary Adrenal Metastases from Breast Invasive Ductal Carcinoma.
    Chirurgia (Bucur) 2017 Jul-Aug;112(4):473-476
    The usual neoplastic dissease involving suprarenal glands are adrenal metastaes. The majority of suprarenal metastatic disease arise from lung cancer, followed by the stomach and colon cancer, oesophagus, the liver/bile ducts cancer and renal cell carcinoma. Invasive mammary carcinoma usually spreads to the bones, lungs, lymph nodes, liver and the brain. Read More

    Nationwide analysis of adrenocortical carcinoma reveals higher perioperative morbidity in functional tumors.
    Am J Surg 2017 Aug 25. Epub 2017 Aug 25.
    Division of Endocrine Surgery, DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL, United States.
    Background: Current adrenalectomy outcomes for functional adrenocortical carcinoma (ACC) remain unclear. This study examines nationwide in-hospital post-adrenalectomy outcomes for ACC.

    Methods: A retrospective analysis of the Nationwide Inpatient Sample database (2006-2011) to identify unilateral adrenalectomy patients for functional or nonfunctional ACC was performed. Read More

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