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    Surgical approaches in hereditary endocrine tumors.
    Updates Surg 2017 Apr 28. Epub 2017 Apr 28.
    Minimally Invasive Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Via Giustiniani 2, 35128, Padua, Italy.
    Endocrine tumors of thyroid, adrenal and parathyroid glands may be due to germline and inheritable mutations in 5-30% of patients. Medullary Thyroid Carcinoma, Pheochromocytoma, Paraganglioma, and Familial Primary Hyperparathyroidism are the most frequent entity. Hereditary endocrine tumors usually have a suggestive familial history; they occur earlier than sporadic variants, are multifocal, and have increased recurrence rates. Read More

    Effect of mitotane on mouse ovarian follicle development and fertility.
    J Endocrinol 2017 Apr 27. Epub 2017 Apr 27.
    A Stigliano, Endocrinology, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
    Mitotane (MTT) is an adrenolytic drug used in advanced and adjuvant treatment of adrenocortical carcinoma, in Cushing's disease and in ectopic syndrome. However, knowledge about its effects on the ovary is still scarce. The purpose of this study is to investigate the effect of MTT on the ovary using in vivo and in vitro models. Read More

    Establishment of a mouse xenograft model of metastatic adrenocortical carcinoma.
    Oncotarget 2017 Apr 7. Epub 2017 Apr 7.
    Université Côte d'Azur, Valbonne - Sophia Antipolis, France.
    Adrenocortical carcinoma is a rare neoplasm with a poor prognosis. Very important advances have been made in the identification of the genetic determinants of adrenocortical carcinoma pathogenesis but our understanding is still limited about the mechanisms that determine cancer spread and metastasis. One major problem hindering preclinical experimentation for new therapies for adrenocortical carcinoma is represented by the lack of suitable animal models for metastatic disease. Read More

    The efficacy of radiation therapy in adrenocortical carcinoma: A propensity score analysis of a population-based study.
    Medicine (Baltimore) 2017 Apr;96(17):e6741
    Department of Urology, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, P.R. China.
    Adrenocortical carcinoma (ACC) is a rare and malignant tumor. The main treatment is primary surgical resection with or without mitotane therapy. The role of radiation therapy is still controversial. Read More

    "Direct MPR": A Useful Tool for Oblique CT Fluoroscopy-Assisted Puncture.
    Cardiovasc Intervent Radiol 2017 Apr 24. Epub 2017 Apr 24.
    Division of Diagnostic Radiology, Shizuoka Cancer Center, Shizuoka, Japan.
    Objective: Conventional multiplanar reconstruction (MPR) imaging can be used as a tool for planning oblique puncture procedures, but it takes a few minutes to reconstruct and is not appropriate for real-time CT fluoroscopy-assisted puncture. Recently, new MPR technology has been used that requires only 8 s and makes it possible to obtain a nearly real-time CT fluoroscopy-assisted oblique puncture. We refer to it as "direct MPR. Read More

    Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial.
    Lancet 2017 Apr 20. Epub 2017 Apr 20.
    Biomedical Research Network in Oncology (CIBERONC), Pamplona, Spain; Center for Applied Medical Research (CIMA), Pamplona, Spain.
    Background: For patients with advanced hepatocellular carcinoma, sorafenib is the only approved drug worldwide, and outcomes remain poor. We aimed to assess the safety and efficacy of nivolumab, a programmed cell death protein-1 (PD-1) immune checkpoint inhibitor, in patients with advanced hepatocellular carcinoma with or without chronic viral hepatitis.

    Methods: We did a phase 1/2, open-label, non-comparative, dose escalation and expansion trial (CheckMate 040) of nivolumab in adults (≥18 years) with histologically confirmed advanced hepatocellular carcinoma with or without hepatitis C or B (HCV or HBV) infection. Read More

    Therapeutic drug monitoring of Mitotane: analytical assay and patient follow-up.
    Biomed Chromatogr 2017 Apr 22. Epub 2017 Apr 22.
    Department of Pharmacology, E.A.3801, Centre Hospitalier Universitaire de Reims, Reims, France.
    Background: Adrenocortical carcinoma (ACC) is an aggressive malignancy of the adrenal gland. Mitotane (o,p'-DDD) is the most effective chemotherapy for ACC. According to literature, mitotane plasma trough concentrations within 14-20 mg. Read More

    Topoisomerase2α and thymidylate synthase expression in adrenocortical cancer.
    Endocr Relat Cancer 2017 Apr 21. Epub 2017 Apr 21.
    M Papotti, pathology, univ of turin, orbassano torino, Italy.
    Topoisomerase II alpha (TOP2A) and Thymidylate Synthase (TS) are known prognostic parameters in several tumors and also predictors of efficacy of anthracyclines, topoisomerase inhibitors and fluoropirimidines, respectively. Expression of TOP2A and TS mRNA was assessed in 98 patients with adrenocortical carcinoma (ACC) and protein expression was assessed by immunohistochemistry in a subset of 39 tumors. Ninety-two patients were radically resected for stage II-III disease and 38 of them received adjuvant mitotane. Read More

    Incidental posterior mediastinal paraganglioma: The safe approach to management, case report.
    Int J Surg Case Rep 2017 Mar 31;35:25-28. Epub 2017 Mar 31.
    Department of Surgery, Division of Thoracic Surgery, Boston University School of Medicine, Boston, MA, USA. Electronic address:
    Introduction: Paragangliomas are neuroendocrine tumors arising from chromaffin cells located in sympathetic paraganglia. Mediastinal paragangliomas are extremely rare and can be classified as functional or non-functional according to their ability for secreting catecholamines. Patients can be asymptomatic and the diagnosis is usually incidental. Read More

    Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma.
    Oncotarget 2017 Apr;8(14):22825-22834
    Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong, P.R. China.
    Adrenocortical carcinoma (ACC) is a rare, but aggressive endocrine malignancy with a generally poor clinical outcome. There is no effective therapy for advanced and metastatic ACC. In our study, we found that an existing drug (rottlerin) exerted its tumour-suppressive function in ACC. Read More

    Next-generation sequencing reveals microRNA markers of adrenocortical tumors malignancy.
    Oncotarget 2017 04 3. Epub 2017 Apr 3.
    Laboratory of Human Cancer Genetics, Centre of New Technologies, CENT, University of Warsaw, Poland.
    Background: Adrenocortical carcinoma is a rare finding among common adrenocortical tumors, but it is highly aggressive and requires early detection and treatment. Still, the differential diagnosis between benign and malignant lesions is difficult even for experienced pathologists and there is a significant need for novel diagnostic methods. In this study we aimed to reveal a complete set of microRNAs expressed in the adrenal gland and to identify easily detectable, stable and objective biomarkers of adrenocortical malignancy. Read More

    A Novel TP53 Mutation Associated with TWIST1 and SIP1 Expression in an Aggressive Adrenocortical Carcinoma.
    Endocr Pathol 2017 Apr 18. Epub 2017 Apr 18.
    Endocrinology Section, Federal Hospital of Lagoa, Rio de Janeiro, Brazil.
    Adrenocortical carcinomas (ACC) are very rare tumors related to TP53 mutations mostly in childhood onset cases. Epithelial-mesenchymal transition (EMT) transcription factors TWIST1 and Smad interacting protein 1 (SIP1) are related to poorer outcomes in other malignancies, but their role in ACC is unknown. We describe a case of an advanced metastatic ACC (Weiss-score of 9) in a patient at age 76. Read More

    Case report: ACTH-secreting pituitary carcinoma metastatic to the liver in a patient with a history of atypical pituitary adenoma and Cushing's disease.
    Diagn Pathol 2017 Apr 18;12(1):34. Epub 2017 Apr 18.
    Department of Pathology, The Ohio State University Wexner Medical Center, 410 W 10th Avenue, Columbus, OH, 43210, USA.
    Background: Pituitary carcinoma is a rare entity requiring the presence of metastasis to confirm its malignant potential. We report a case of pituitary carcinoma and discuss the diagnosis and management of this lesion in relation to the existing literature.

    Case Presentation: The patient is a 51-year-old woman with Cushing's disease and intact adrenal glands who was diagnosed with metastatic pituitary carcinoma to the liver, 29 months after initial resection of an ACTH-secreting primary atypical pituitary adenoma (APA). Read More

    Multilocular cystic renal cell carcinoma: pathological t staging makes no difference to favorable outcomes and should be reclassified. Bhatt JR, Jewett MA, Richard PO, Kawaguchi S, Timilshina N, Evans A, Alibhai S, Finelli A.J Urol. November 2016;196(5):1350-1355.
    Urol Oncol 2017 Apr 13. Epub 2017 Apr 13.
    Objective: We evaluated survival outcomes of cystic/multilocular cystic renal cell carcinomas in a long-term population-based study based on size and pathological tumor stage.

    Materials And Methods: We, retrospectively, reviewed a provincial cancer registry of all histologically proven cases of multilocular cystic renal cancers treated surgically between 1995 and 2008. All cases of cystic necrosis were excluded from study. Read More

    Paraganglioma of the bladder in a kidney transplant recipient: A case report.
    Mol Clin Oncol 2017 Apr 6;6(4):553-555. Epub 2017 Mar 6.
    Department of Nephrology and Kidney Transplantation, Necker Enfants-Malades Hospital, Paris Descartes University, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France.
    Renal transplantation has been associated with a significantly increased risk of developing cancer, including bladder neoplasia, with urothelial carcinoma being the most frequent type of bladder cancer. Bladder paraganglioma, also referred to as extra-adrenal pheochromocytoma, is a rare but severe condition that may cause a severe hypertensive crisis during handling and mobilization of the tumor. We herein present the case of a 67-year-old kidney transplant recipient with a bladder polyp consistent with paraganglioma of the bladder. Read More

    The aurora kinase inhibitor AMG 900 increases apoptosis and induces chemosensitivity to anticancer drugs in the NCI-H295 adrenocortical carcinoma cell line.
    Anticancer Drugs 2017 Apr 13. Epub 2017 Apr 13.
    Departments of aGenetics bPediatrics cHemocenter, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil dSeattle Biomedical Research Institute, Seattle, Washington, USA.
    Adrenocortical tumor (ACT) is a malignancy with a low incidence rate and the current therapy for advanced disease has a limited impact on overall patient survival. A previous study from our group suggested that elevated expression of aurora-A and aurora-B is associated with poor outcome in childhood ACT. Similar results were also reported for adult ACTs. Read More

    Laparoscopic radical antegrade modular pancreatosplenectomy for left-sided pancreatic cancer using the ligament of Treitz approach.
    Surg Endosc 2017 Apr 13. Epub 2017 Apr 13.
    Department of Surgery, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama, 710-8602, Japan.
    Background: Laparoscopic distal pancreatectomy (Lap-DP) for benign lesions or those with low malignant potential has been proven safe and effective, and its performance is now widespread [1-3]. Lap-DP for left-sided pancreatic cancer (PC) is also being increasingly performed. According to some reports, Lap-DP has superior short-term outcomes (blood loss, postoperative hospital stay) and comparable oncological outcomes and overall survival with those of open distal pancreatectomy (Op-DP) [4-6]. Read More

    A Rare Collision Tumour of Uterus- Squamous Cell Carcinoma and Endometrial Stromal Sarcoma.
    J Clin Diagn Res 2017 Feb 1;11(2):ED20-ED22. Epub 2017 Feb 1.
    Director and Professor, Department of Obstetrics and Gynaecology, University College of Medical Sciences , Delhi, India .
    Collision tumours are defined by co-existence of two tumours in the same or adjacent organs which are topographically and histologically distinct with minimal or no histological admixture. Collision tumours have been described in many organs notably thyroid, brain, adrenal gland, stomach and rarely uterus. Most of the collision tumours reported in uterus have two components; an adenocarcinoma and a sarcoma. Read More

    Atypical cytologic presentation of a histiocytic sarcoma in a Cavalier King Charles Spaniel dog.
    J Vet Diagn Invest 2017 Apr 1:1040638717701521. Epub 2017 Apr 1.
    Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA.
    A Cavalier King Charles Spaniel dog was presented because of a 10-d history of progressive vomiting, inappetence, and lethargy, with mild neurologic signs. Fine-needle aspirates of splenic nodules seen on ultrasound were suggestive of a carcinoma. On autopsy, a disseminated neoplasm was present in the lung, spleen, and adrenal glands. Read More

    Myxoid and Sarcomatoid Variants of Adrenocortical Carcinoma: Analysis of Rare Variants in Single Tertiary Care Center.
    J Korean Med Sci 2017 May;32(5):764-771
    Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
    The aim of this study is to describe rare variants of adrenocortical carcinoma (ACC) and to compare the prognosis with that of conventional ACC. We retrospectively reviewed 8 cases of myxoid variant, 1 sarcomatoid variant, and 14 cases of conventional ACC, who underwent surgical resection at the Asan Medical Center between 1996 and 2014. An analysis of the clinicopathological characteristics, including the Weiss score, Ki-67 labeling index, and reticulin framework assessment is presented. Read More

    Utility of GATA3 in the Differential Diagnosis of Pheochromocytoma.
    Histopathology 2017 Apr 4. Epub 2017 Apr 4.
    Department of Pathology, The Ohio State University Medical Center, 410 W 10th Ave., 401 Doan Hall, Columbus, OH 43210.
    Aims: GATA3 is a relatively new immunohistochemical marker which shows consistent nuclear expression in a variety of tumors, including breast and urothelial carcinoma. The staining pattern of GATA3 in adrenal lesions is not well established. We aim to describe the expression of GATA3 in adrenal tumors and determine if there is differential staining between pheochromocytoma and adrenal cortical carcinoma. Read More

    P53/Rb inhibition induces metastatic adrenocortical carcinomas in a preclinical transgenic model.
    Oncogene 2017 Apr 3. Epub 2017 Apr 3.
    CNRS UMR6293, GReD, INSERM U1103, Université Clermont Auvergne, Aubière, France.
    Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Pan-genomic analyses identified p53/Rb and WNT/β-catenin signaling pathways as main contributors to the disease. However, isolated β-catenin constitutive activation failed to induce malignant progression in mouse adrenocortical tumors. Read More

    Renal Medullary Carcinoma; A Rare Entity.
    Iran J Med Sci 2017 Mar;42(2):215-218
    Department of Pathology, Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey.
    Renal medullary carcinoma (RMC) is an uncommon aggressive neoplasm of the kidney. RMC is biologically aggressive with a very poor prognosis, and metastasis is seen in up to 95% of the patients at diagnosis or shortly thereafter. The common sites of metastasis are respectively lymph nodes, lungs, livers, and adrenal glands in order of frequency. Read More

    Complications After Metastasectomy for Renal Cell Carcinoma-A Population-based Assessment.
    Eur Urol 2017 Mar 27. Epub 2017 Mar 27.
    Department of Medical Oncology, Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. Electronic address:
    Metastasectomy has long been considered a valid treatment option for patients with oligometastatic renal cell carcinoma (oligo-mRCC). However, the literature on complications in this setting is scarce. Our objective was to describe in-hospital complications after metastasectomy in a contemporary cohort of patients with mRCC. Read More

    Radiotherapy for adrenal gland metastases from hepatocellular carcinoma.
    Clin Transl Oncol 2017 Mar 29. Epub 2017 Mar 29.
    Department of Radiation Oncology, Zhongshan Hospital, Fudan University, No. 180 Feng Lin Road, Shanghai, 200032, China.
    Background: Several studies have found benefits of radiotherapy for adrenal metastasis from hepatocellular carcinoma (HCC). However, the efficacy, safety and outcome issues have not yet been fully addressed. Therefore, we performed this study to further elucidate the feasibility and outcome of radiotherapy in treating adrenal metastasis from HCC. Read More

    Adrenocortical carcinoma masquerading as Cushing's disease.
    BMJ Case Rep 2017 Mar 29;2017. Epub 2017 Mar 29.
    Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    Cushing's syndrome (CS) can be classified as adrenocorticotropic hormone (ACTH)-dependent or ACTH-independent depending on the ACTH levels. However, 30% of the patients with CS have ACTH levels in the 'grey zone' (5-20 pg/mL), thereby posing a challenge in establishing the aetiological diagnosis. In a patient with full-blown features of Cushing's syndrome with equivocal ACTH levels, and a pituitary microadenoma on contrast-enhanced MRI sella, can falsely lead to a diagnosis of Cushing's disease. Read More

    From benign adrenal incidentaloma to adrenocortical carcinoma: an exceptional random event.
    Eur J Endocrinol 2017 Jun 27;176(6):K15-K19. Epub 2017 Mar 27.
    Department of EndocrinologyCenter for Rare Adrenal Diseases, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris, France
    New European guidelines for the management of adrenal incidentalomas were recently released. One of the most novel recommendations is to stop following patients when they present a typical, small and non-secreting adenoma. We report here the case of a 71-year-old man with such an adenoma, who developed an adrenocortical carcinoma (ACC) fourteen years later, with subsequent metastases and death. Read More

    [Circulating microRNAs in the diagnostics of endocrine neoplasms].
    Orv Hetil 2017 Apr;158(13):483-490
    II. Belgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Üllői út 26., 1085.
    MicroRNAs (miRNA, miR) are short - 19-25 nucleotide long - single stranded (in their mature form), non-coding RNA molecules that regulate gene expression mostly at the posttranscriptional level. microRNAs are involved in the regulation of various physiological processes such as cell differentiation and proliferation, development, haematopoesis, cell death, while their aberrant expression is observed in numerous diseases, like autoimmune disorders, inflammations, vascular diseases or tumorigenesis. microRNAs are expressed in a tissue specific fashion. Read More

    Long-Term Outcomes of Adjuvant Mitotane Therapy in Patients With Radically Resected Adrenocortical Carcinoma.
    J Clin Endocrinol Metab 2017 Apr;102(4):1358-1365
    Internal Medicine 1, Department of Clinical and Biological Sciences, San Luigi Hospital.
    Context: In 2007, a retrospective case-control study provided evidence that adjuvant mitotane prolongs recurrence-free survival (RFS) in patients with radically resected adrenocortical carcinoma (ACC).

    Objective And Design: We aimed to confirm the prognostic role of adjuvant mitotane in the same series after 9 additional years of follow-up.

    Setting, Patients, And Interventions: One hundred sixty-two ACC patients who did not recur or die after a landmark period of 3 months were considered. Read More

    Evaluation of kidney motion and target localization in abdominal SBRT patients.
    J Appl Clin Med Phys 2016 Nov;17(6):429-433
    Medical Physics, Sunnybrook Odette Cancer Centre, Toronto, ON, Canada.
    The purpose of this study was to evaluate bilateral kidney and target translational/rotational intrafraction motion during stereotactic body radiation therapy treatment delivery of primary renal cell carcinoma and oligometastatic adrenal lesions for patients immobilized in the Elekta BodyFIX system. Bilateral kidney motion was assessed at midplane for 30 patients immobilized in a full-body dual-vacuum-cushion system with two patients immobilized via abdominal compression. Intrafraction motion was assessed for 15 patients using kilovoltage cone-beam computed tomography (kV-CBCT) datasets (n=151) correlated to the planning CT. Read More

    [Primary epithelioid adrenal angiosarcoma mimicking undifferentiated carcinoma].
    Ann Pathol 2017 Apr 11;37(2):162-165. Epub 2017 Mar 11.
    Service de pathologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France; Inserm UMR-S-1165, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France. Electronic address:
    The adrenal primary epithelioid angiosarcoma (ASE) is a rare malignant tumor which can be histologically confused with other neoplasms. We report one case in a 79-year-old man who underwent adrenal tumor surgery for a mass fortuitly discovered by imaging for examination of an inflammatory syndrome associated with anemia. The histological diagnosis was difficult because of the undifferentiated and epithelioid appearance of tumor cells, whose immunohistochemical epithelial markers positivity led to frequent confusion with a metastatic carcinoma. Read More

    Clear cell colorectal carcinoma: Time to clarify diagnosis.
    Pathol Res Pract 2017 Feb 24. Epub 2017 Feb 24.
    Department of Diagnostics and Public Health, University and Hospital Trust of Verona, ARC-Net Research Center, Verona, Italy.
    Primary clear cell colorectal carcinoma (CCC) is a very rare entity accounting for only 35 cases reported in the Literature. CCC is neither classified as a distinct entity nor is it defined as a CRC variant because its ontogeny remains unclear. Most of the reported CCC were found in the distal colon in patients with a mean age of 56 years. Read More

    Update on adrenocortical carcinoma management and future directions.
    Curr Opin Endocrinol Diabetes Obes 2017 Mar 8. Epub 2017 Mar 8.
    Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Purpose Of Review: To present an update on the management of and future directions in adrenocortical carcinoma (ACC).

    Recent Findings: ACC is a rare malignancy with high morbidity and mortality. Surgery remains the mainstay treatment for localized disease, but it is often not feasible in more advanced cases. Read More

    Assessment of Depression, Anxiety, Quality of Life, and Coping in Long-Standing Multiple Endocrine Neoplasia Type 2 Patients.
    Thyroid 2017 Apr 4. Epub 2017 Apr 4.
    1 Endocrine Genetics Unit (LIM-25), Endocrinology Division, Hospital das Clínicas, University of São Paulo School of Medicine , São Paulo, Brazil .
    Background: Data on psychological harm in multiple endocrine neoplasia type 2 (MEN2) are scarce.

    Objectives: The aim of this study was to assess anxiety, depression, quality of life, and coping in long-standing MEN2 patients.

    Patients And Methods: Patients were 43 adults (age ≥18 years) with clinical and genetic diagnosis of MEN2 and long-term follow-up (10. Read More

    Tissue Expression and Pharmacological In Vitro Analyses of mTOR and SSTR Pathways in Adrenocortical Carcinoma.
    Endocr Pathol 2017 Mar 7. Epub 2017 Mar 7.
    Department of Clinical and Biological Sciences and Department of Oncology, University of Turin at San Luigi Hospital, Regione Gonzole 10, 10043 Orbassano, Turin, Italy.
    New therapies for advanced adrenocortical carcinoma (ACC) are urgently needed, as the majority of the patients experience a rapid and inexorable progression despite surgery and adjuvant mitotane. In vitro data suggest that somatostatin receptors (SSTRs) and mTOR pathway might represent reasonable targets for novel therapies, being involved in functionality and growth of ACC cells. However, in vitro analysis of combination treatments targeting both mTOR and SSTR as compared to mitotane are poorly explored in ACC. Read More

    Dosage-dependent regulation of VAV2 expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasion.
    Sci Signal 2017 Mar 7;10(469). Epub 2017 Mar 7.
    Université Côte d'Azur, Sophia Antipolis, 06560 Valbonne, France.
    Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a dismal prognosis. Genomic studies have enabled progress in our understanding of the molecular bases of ACC, but factors that influence its prognosis are lacking. Amplification of the gene encoding the transcription factor steroidogenic factor-1 (SF-1; also known as NR5A1) is one of the genetic alterations common in ACC. Read More

    [Long-term blood pressure outcome after unilateral adrenalectomy for primary hyperaldosteronism].
    Prog Urol 2017 Mar 1. Epub 2017 Mar 1.
    Service d'endocrinologie, maladies métaboliques, diabétologie et nutrition, université de Picardie Jules-Verne, CHU d'Amiens, 80000 Amiens, France.
    Objectives: To evaluate long-term results of adrenalectomy for primary aldosteronism (PA) and to identify prognostic factors associated.

    Methods: Exhaustive retrospective review of all consecutive patients undergoing adrenalectomy for PA between 2002 and 2013 in our department. All patients underwent preoperative: clinical evaluation (age, sex, height, weight, systolic and diastolic BP under treatment, identification of anti-hypertension treatment), biological evaluation (potassium, renin, aldosterone) and radiological evaluation (CT and/or MRI). Read More

    Adrenocortical Carcinoma Arising in an Adrenal Rest: a Case Report and Review of the Literature.
    Endocr Pathol 2017 Mar 3. Epub 2017 Mar 3.
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, MA, USA.
    Carcinomas arising from embryonic adrenal rests are rare with only a handful of reported cases. We report a case of an adrenocortical carcinoma arising from an adrenal rest located between the bladder and prostate in a 51 year-old man. The patient presented following a year of rectal pain and constipation. Read More

    Pneumocystis Pneumonia Concomitant with Ectopic ACTH Syndrome Caused by a Large Cell Neuroendocrine Carcinoma of the Thymus.
    Intern Med 2017 1;56(5):551-555. Epub 2017 Mar 1.
    Department of Allergy and Respiratory Medicine, Okayama University Hospital, Japan.
    We herein report the case of a 44-year-old man who was diagnosed with pneumocystis pneumonia (PCP) concomitant with ectopic adrenocorticotropic hormone (ACTH) syndrome, which had been caused by a large cell neuroendocrine carcinoma of the thymus. Chest computed tomography revealed ground-glass opacities in the lungs. PCP was diagnosed by a polymerase chain reaction with bronchoalveolar lavage. Read More

    A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis.
    BMC Cancer 2017 Mar 1;17(1):164. Epub 2017 Mar 1.
    Department of Surgery & Yale Endocrine Neoplasia Laboratory, Yale University School of Medicine, New Haven, CT, USA.
    Background: Dysregulated WNT signaling dominates adrenocortical malignancies. This study investigates whether silencing of the WNT negative regulator DKK3 (Dickkopf-related protein 3), an implicated adrenocortical differentiation marker and an established tumor suppressor in multiple cancers, allows dedifferentiation of the adrenal cortex.

    Methods: We analyzed the expression and regulation of DKK3 in human adrenocortical carcinoma (ACC) by qRT-PCR, immunofluorescence, promoter methylation assay, and copy number analysis. Read More

    Hepatopulmonary syndrome is associated with the presence of hepatocellular carcinoma in patients with decompensated cirrhosis.
    Ann Gastroenterol 2017 22;30(2):225-231. Epub 2016 Dec 22.
    4 Department of Internal Medicine, Hippokration University Hospital, Medical School, Aristotle University of Thessaloniki (Stergios Soulaidopoulos, Ioannis Goulis, Petros Doumtsis, Areti Karasmani, Theodora Oikonomou, Theodora Tzoumari, Evangelos Cholongitas).
    Background: Hepatopulmonary syndrome (HPS) is a relatively common complication in patients with decompensated cirrhosis. Our aim was to evaluate the prevalence of HPS, its clinical impact, and the possible association between HPS and characteristics of patients with decompensated cirrhosis.

    Methods: Patients with stable decompensated cirrhosis admitted to our department and assessed for HPS were included. Read More

    Nivolumab induced myxedema crisis.
    J Immunother Cancer 2017 21;5:13. Epub 2017 Feb 21.
    Department of Hematology/Oncology, St. John Hospital and Medical Center, 19229 Mack Ave Suite 23 Grosse Pointe Woods, Detroit, 48236 Michigan USA.
    Background: Nivolumab is an anti-programmed cell death (anti-PD-1) monoclonal antibody that is approved by Food and Drug Administration for treatment of metastatic non-small cell lung cancer, metastatic melanoma, relapsed Hodgkin lymphoma and advanced renal cell cancer. We report a rare case of myxedema crisis induced by nivolumab in a patient with metastatic squamous cell carcinoma of lung.

    Case Presentation: Fifty three-year old woman with metastatic squamous cell carcinoma currently on treatment with nivolumab presented with diffuse facial and tongue swelling, slurred speech, depressed mentation, fatigue and weakness. Read More

    Diagnosis of a malignant adrenal mass: the role of urinary steroid metabolite profiling.
    Curr Opin Endocrinol Diabetes Obes 2017 Feb 23. Epub 2017 Feb 23.
    aDivision of Endocrinology, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA bInstitute of Metabolism and Systems Research (IMSR), University of Birmingham cCentre for Endocrinology, Diabetes and Metabolism (CEDAM), Birmingham Health Partners, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
    Purpose Of Review: Adrenal masses are highly prevalent, found in 5% of the population. Differentiation of benign adrenocortical adenoma from adrenocortical carcinoma is currently hampered by the poor specificity and limited evidence base of imaging tests. This review summarizes the results of studies published to date on urine steroid metabolite profiling for distinguishing benign from malignant adrenal masses. Read More

    Preoperative adrenal biopsy does not affect overall survival in adrenocortical carcinoma.
    Am J Surg 2017 Feb 1. Epub 2017 Feb 1.
    Department of Surgery, NorthShore University Health System, USA.
    Background: The impact of preoperative biopsy on overall survival (OS) in adrenocortical carcinoma (ACC) is unclear. We analyzed the National Cancer Data Base (NCDB) for factors associated with preoperative adrenal biopsy and its effect on OS in ACC.

    Methods: The NCDB was queried from 2003 to 2012 for M0 ACC. Read More

    Surgical treatment of lung cancer with synchronous adrenal metastases: Adrenalectomy first.
    Cir Esp 2017 Feb 21;95(2):97-101. Epub 2017 Feb 21.
    Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario Mutua Terrassa, Tarrasa (Barcelona), España.
    Introduction: The aim of this study is to present our patients with lung cancer and synchronous adrenal metastases treated with a reversal approach: starting with adrenalectomy and doing the lung resection second.

    Methods: A total of 108 laparoscopic adrenalectomies were performed, and we analyze a consecutive serie of 10 patients with isolated adrenal synchronous metastases from the lung, surgically treated in a sequential way. All patients underwent staging mediastinoscopy, and patients with positive lymph nodes were primary treated with chemotherapy. Read More

    Jejunal metastasis of renal cell carcinoma.
    Rev Esp Enferm Dig 2017 Feb;109(2):147-148
    Aparato Digestivo, Complejo Hospitalario Universitario de Vigo.
    A 71-year-old female presented with melena and anemia. She had a past medical history of renal cell carcinoma diagnosed six years earlier and treated with left nephrectomy. Gastroscopy and colonoscopy showed no abnormalities. Read More

    Tumor-Associated Neutrophils and Macrophages Promote Gender Disparity in Hepatocellular Carcinoma in Zebrafish.
    Cancer Res 2017 Mar 15;77(6):1395-1407. Epub 2017 Feb 15.
    Department of Biological Sciences, National University of Singapore, Singapore.
    Hepatocellular carcinoma (HCC) occurs more frequently and aggressively in men than women, but the mechanistic basis of this gender disparity is obscure. Chronic inflammation is a major etiologic factor in HCC, so we investigated the role of cortisol in gender discrepancy in a zebrafish model of HCC. Inducible expression of oncogenic Kras(V12) in hepatocytes of transgenic zebrafish resulted in accelerated liver tumor progression in males. Read More

    Mixed corticomedullary adrenal carcinoma - case report: Comparison in features, treatment and prognosis with the other two reported cases.
    Int J Surg Case Rep 2017 31;31:254-261. Epub 2017 Jan 31.
    Alberoni Hospital, Damascus University Faculty of Medicine, P.O. Box: 60527, Damascus, Syria. Electronic address:
    Introduction: Adrenal corticomedullary adenoma was reviewed in many cases in PubMed Library, While the coincidence corticomedullary adrenal carcinoma in the same gland was just described in two cases in the medical literature. Our case is the third to be reported and was treated with surgery and adjuvant chemotherapy and followed for two years.

    Presentation Of Case: A 50-year-old man suffered from a mass effect in the left abdominal side. Read More

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