9,808 results match your criteria Adrenal Carcinoma


Adrenocortical cancer cell line mutational profile reveals aggressive genetic background.

J Mol Endocrinol 2019 Mar 1. Epub 2019 Mar 1.

T Carling, Department of Surgery, Yale School of Medicine, New Haven, United States.

Adrenocortical carcinomas are rare tumors with poor prognosis and limited treatment options. Although widely used as in vitro models to test novel therapeutic strategies, the adrenocortical carcinoma-derived cell lines NCI-H295R and SW-13 have been only partially described genetically. Our aim was to characterize the mutational landscape of these cells to improve their experimental utility and map them to clinical sub-types of adrenocortical carcinoma. Read More

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http://dx.doi.org/10.1530/JME-18-0262DOI Listing

LARGE ADRENAL INCIDENTALOMAS REQUIRE A DEDICATED DIAGNOSTIC PROCEDURE.

Endocr Pract 2019 Mar 13. Epub 2019 Mar 13.

From : Aix Marseille Université, Assistance Publique Hôpitaux de Marseille, Marseille, France.

Introduction: The management of large non secreting adrenal tumors (at least 4 cm) is still a matter of debate as it is unclear whether imaging, especially 18F-FDG, can be used to characterize their potential malignancy. Moreover, the risk of new hypersecretion in non-operated tumors is uncertain. Our aim was to better characterize these large adrenal incidentalomas. Read More

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http://dx.doi.org/10.4158/EP-2018-0616DOI Listing

A case of metastatic adrenocortical carcinoma.

Authors:
N Kuthiah C Er

Oxf Med Case Reports 2019 Feb 27;2019(2):omz006. Epub 2019 Feb 27.

General Medicine, Alexandra Health System Woodlands Health Campus, Singapore.

Adrenocortical carcinoma is a rare endocrine malignancy with poor prognosis. Adrenocortical carcinoma can be seen in familial syndromes such as multiple endocrine neoplasia 1(MEN-1), Li-Fraumeni syndrome, Beckwith-Wiedemann syndrome and Carney complex (Kjellman, M, Roshani, L, The, BT . Genotyping of adrenocortical tumours: very frequent deletions of the MEN1 locus in 11q13 and of a 1-centimorgan region in 2p16. Read More

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http://dx.doi.org/10.1093/omcr/omz006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402308PMC
February 2019

Precocious pseudopuberty due to virilising adrenocortical carcinoma progressing to central precocious puberty after surgery.

BMJ Case Rep 2019 Mar 12;12(3). Epub 2019 Mar 12.

Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, Delhi, India.

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2019-22947
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http://dx.doi.org/10.1136/bcr-2019-229476DOI Listing
March 2019
4 Reads

The Utrecht Score: A Novel Histopathological Scoring System to Assess the Prognosis of Dogs with Cortisol-Secreting Adrenocortical Tumours.

Vet Comp Oncol 2019 Mar 12. Epub 2019 Mar 12.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.

A cortisol-secreting adrenocortical tumour (ACT) is the cause of naturally occurring canine hypercortisolism in approximately 15-20% of cases. The differentiation between an adrenocortical adenoma and carcinoma is usually based on histopathology. However, histopathological parameters have never been linked to the dogs' survival. Read More

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http://dx.doi.org/10.1111/vco.12474DOI Listing

Erythrocytosis as the first manifestation of adrenal carcinoma.

Pediatr Blood Cancer 2019 Mar 11:e27685. Epub 2019 Mar 11.

G. Martino Hospital, Pediatric Unit, Department of Adulthood and Childhood Human Pathology, University of Messina, Messina, Italy.

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http://dx.doi.org/10.1002/pbc.27685DOI Listing

Minimally Invasive Surgery for Primary and Metastatic Adrenal Malignancy.

Surg Oncol Clin N Am 2019 04 11;28(2):309-326. Epub 2019 Jan 11.

Department of Surgical Oncology, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Since the first description of laparoscopic adrenalectomy (LA) for pheochromocytoma and Cushing syndrome in 1992, the utilization of and indications for a minimally invasive approach to the adrenal gland have vastly expanded. Although minimally invasive adrenalectomy has been established as the preferred approach for patients with benign tumors of the adrenal gland, minimally invasive adrenalectomy for cancer remains controversial. In this article, the authors review the indications for minimally invasive adrenalectomy for adrenal nodules suspicious for, or established to represent, a primary malignancy or a site of metastatic cancer. Read More

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http://dx.doi.org/10.1016/j.soc.2018.11.011DOI Listing
April 2019
2 Reads

Screening in adrenal tumors.

Curr Opin Oncol 2019 Mar 5. Epub 2019 Mar 5.

Department of Medicine, Division of Endocrinology.

Purpose Of Review: Adrenal tumors are mostly encountered as incidentalomas in patients undergoing imaging not performed for suspected adrenal disease; although the majority are benign and nonfunctioning, malignant tumors and functioning tumors need to be excluded. The purpose of this review is to highlight recent advances in the evaluation of adrenal tumors.

Recent Findings: As a consequence of increased use of technologically improved imaging techniques, the detection of adrenal incidentalomas has continued to increase. Read More

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http://dx.doi.org/10.1097/CCO.0000000000000528DOI Listing
March 2019
2 Reads

Minichromosome Maintenance Proteins MCM-3, MCM-5, MCM-7, and Ki-67 as Proliferative Markers in Adrenocortical Tumors.

Anticancer Res 2019 Mar;39(3):1151-1159

Department of General, Minimally Invasive and Endocrine Surgery, Wroclaw Medical University, Wroclaw, Poland.

Background/aim: Morphological features, combined with Ki-67 proliferative index, remain the standard for discriminating benign and malignant adrenocortical tumors. The aim of this study was to evaluate the role of minichromosome maintenance proteins MCM-3, MCM-5, MCM-7, and Ki-67 as proliferative markers in adrenocortical tumors.

Materials And Methods: Specimens of 81 adrenocortical adenomas and 3 adrenocortical carcinomas were stained with antibodies against MCM-3, 5, 7 and Ki-67. Read More

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http://dx.doi.org/10.21873/anticanres.13224DOI Listing
March 2019
2 Reads

IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer.

Endocrine 2019 Mar 5. Epub 2019 Mar 5.

Department of Internal Medicine, Division Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands.

Purpose: The IGF and mTOR-pathways are considered as potential targets for therapy in patients with adrenocortical carcinoma (ACC). This study aims to describe the IGF pathway in ACC and to explore the response to the combined treatment with the IGF1R/IR inhibitor linsitinib, and mTOR inhibitors (sirolimus and everolimus) in in vitro models of ACC.

Methods: The protein expression level of IGF2, IGF1R and IGF2R was evaluated by immunohistochemistry in 17 human ACCs and the mRNA expression level of IGF1, IGF2, IGF1R, IR isoforms A and B, IGF2R, IGF-Binding-Proteins[IGFBP]-1, 2, 3 and 6 was evaluated by RT-qPCR in 12 samples. Read More

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http://dx.doi.org/10.1007/s12020-019-01869-1DOI Listing
March 2019
1 Read
3.527 Impact Factor

Multiple endocrine neoplasia type 2A syndrome (MEN2A) and usefulness of 68Ga-DOTATATE PET/CT in this syndrome.

Ann Ital Chir 2019 Mar 4;8. Epub 2019 Mar 4.

Aim: The aim of this study was to evaluate a new imaging method 68Ga-DOTATATE PET/CT as an alternative method to diagnose evidence of neuroendocrine tumors or their metastasis (if any) in patient with MEN 2A.

Methods: Three patients( 2F, 1M; age 28,46 and 50 years) with MEN 2A syndrome who underwent 68Ga-DOTATATE PET/CT scan were prospectively evaluated. PET/CT images were analyzed with measurement of maximum standardized uptake value (SUVmax). Read More

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March 2019
4 Reads

First-line pembrolizumab therapy in a cisplatin-ineligible patient with plasmacytoid urothelial carcinoma: A case report.

J Oncol Pharm Pract 2019 Mar 4:1078155219835006. Epub 2019 Mar 4.

1 Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.

Background: Plasmacytoid urothelial carcinoma (PUC) is a rare but aggressive variant of transitional cell carcinoma. In patients with unresectable disease, cisplatin-based combination chemotherapy is the most commonly used treatment. However, many patients are cisplatin-ineligible due to poor performance status or other comorbidities. Read More

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http://dx.doi.org/10.1177/1078155219835006DOI Listing
March 2019
2 Reads

A case report of a TDM-guided optimization of mitotane for a safe and effective long-term treatment.

J Chemother 2019 Mar 4:1-4. Epub 2019 Mar 4.

a Department of Clinical and Experimental Medicine , University of Pisa , Pisa , Italy.

A 43-years old woman was diagnosed an adrenocortical carcinoma (AC) that was excised, whereas two lung metastases were un-operable. Mitotane 6 g/day was started as standard therapy but it was responsible for severe central nervous system (CNS) and gastrointestinal toxicities associated with a 10 kg body weight loss. A therapeutic drug monitoring (TDM) protocol demonstrated that mitotane plasma concentrations (>30 mg/L) exceeded the therapeutic range (14-20 mg/L) and increased even when drug daily dose was reduced by 50%. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1552502DOI Listing
March 2019
2 Reads

Ablative Transarterial Radioembolization of a Parasitized Adrenal Artery for the Treatment of Hepatocellular Carcinoma.

J Vasc Interv Radiol 2019 Mar;30(3):473-476

Division of Interventional Radiology, Mayo Clinic, 4500 San Pablo Rd S, Jacksonville, FL 32224.

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http://dx.doi.org/10.1016/j.jvir.2018.10.022DOI Listing
March 2019
1 Read

Expression profiles analysis identifies the values of carcinogenesis and the prognostic prediction of three genes in adrenocortical carcinoma.

Oncol Rep 2019 Feb 19. Epub 2019 Feb 19.

Department of Urology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.

Adrenocortical carcinoma (ACC) is a rare disease associated with a poor prognosis. Furthermore, the underlying molecular mechanism of carcinogenesis is poorly understood, and prognostic prediction of ACC has low accuracy. In the present study, a bioinformatics approach was used to investigate the molecular mechanisms and prognosis of ACC. Read More

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http://dx.doi.org/10.3892/or.2019.7021DOI Listing
February 2019
2 Reads

A unique case of ectopic Cushing's syndrome from a thymic neuroendocrine carcinoma.

Endocrinol Diabetes Metab Case Rep 2019 Feb 22;2019. Epub 2019 Feb 22.

Departments of Endocrinology, Diabetes & Metabolism, Cleveland Clinic, Cleveland, Ohio, USA.

Ectopic adrenocorticotropic hormone (ACTH) production leading to ectopic ACTH syndrome accounts for a small proportion of all Cushing's syndrome (CS) cases. Thymic neuroendocrine tumors are rare neoplasms that may secrete ACTH leading to rapid development of hypercortisolism causing electrolyte and metabolic abnormalities, uncontrolled hypertension and an increased risk for opportunistic infections. We present a unique case of a patient who presented with a mediastinal mass, revealed to be an ACTH-secreting thymic neuroendocrine tumor (NET) causing ectopic CS. Read More

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http://dx.doi.org/10.1530/EDM-19-0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391898PMC
February 2019

Low-dose etomidate for the management of severe hypercortisolaemia in different clinical scenarios: a case series and review of the literature.

Ther Adv Endocrinol Metab 2019 8;10:2042018819825541. Epub 2019 Feb 8.

Department of Endocrinology, Centre of Postgraduate Medical Education, Bielański Hospital in Warsaw, Poland.

Background: Severe Cushing's syndrome (SCS) is associated with acute cardiovascular, metabolic and infectious complications. It is considered an emergency, requiring an immediate diagnosis, together with a broad spectrum of supportive and hypocortisolaemic treatments. Surgical intervention, aimed at removing the source of cortisol or adrenocorticotropic hormone (ACTH), is the optimal treatment in most cases of Cushing's syndrome. Read More

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http://dx.doi.org/10.1177/2042018819825541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378481PMC
February 2019

Management of Adrenocortical Carcinoma.

Curr Oncol Rep 2019 Feb 23;21(3):20. Epub 2019 Feb 23.

Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1461, Houston, TX, 77030, USA.

Purpose Of Review: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy typically with poor prognosis. This review aims to summarize the current knowledge regarding the clinical management of ACC.

Recent Findings: Surgery remains the cornerstone for localized ACC management. Read More

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http://dx.doi.org/10.1007/s11912-019-0773-7DOI Listing
February 2019
1 Read

Frequency and imaging features of abdominal immune-related adverse events in metastatic lung cancer patients treated with PD-1 inhibitor.

Abdom Radiol (NY) 2019 Feb 21. Epub 2019 Feb 21.

Department of Medical Oncology and Department of Medicine, Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.

Purpose: To investigate the frequency and imaging features of radiographically evident abdominal immune-related adverse events (irAEs) in patients with metastatic non-small-cell lung cancer (NSCLC) treated with PD-1 inhibitors.

Methods: This retrospective study included 137 patients with metastatic NSCLC treated with PD-1 inhibitor nivolumab monotherapy (75 women; median age: 65 years), who had a baseline CT and at least one follow-up abdomen CT during therapy. Baseline and all follow-up abdominal CTs performed for monitoring of nivolumab therapy were reviewed to identify the organ-specific abdominal irAEs including colitis/enteritis, hepatitis, biliary toxicity, pancreatitis, nephritis, sarcoid-like reaction, and pancreatic and adrenal atrophy. Read More

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http://dx.doi.org/10.1007/s00261-019-01935-2DOI Listing
February 2019

In vitro modulation of multidrug resistance by pregnane steroids and in vivo inhibition of tumour development by 7α-OBz-11α(R)-OTHP-5β-pregnanedione in K562/R7 and H295R cell xenografts.

J Enzyme Inhib Med Chem 2019 Dec;34(1):684-691

a ISPB-Faculté de Pharmacie , Université de Lyon, Université Lyon 1 , Lyon , France.

Synthetic progesterone and 5α/β-pregnane-3,20-dione derivatives were evaluated as in vitro and in vivo modulators of multidrug-resistance (MDR) using two P-gp-expressing human cell lines, the non-steroidogenic K562/R7 erythroleukaemia cells and the steroidogenic NCI-H295R adrenocortical carcinoma cells, both resistant to doxorubicin. The maximal effect in both cell lines was observed for 7α-O-benzoyloxy,11α(R)-O-tetrahydropyranyloxy-5β-pregnane-3,20-dione 4. This modulator co-injected with doxorubicin significantly decreased the tumour size and increased the survival time of immunodeficient mice xenografted with NCI-H295R or K562/R7 cells. Read More

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http://dx.doi.org/10.1080/14756366.2019.1575825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383615PMC
December 2019
2 Reads

Small Cell Lung Cancer with Pituitary Metastasis Presenting as Secondary Adrenal Insufficiency: A Case Report and Literature Review.

Am J Case Rep 2019 Feb 17;20:207-211. Epub 2019 Feb 17.

Department of Endocrinology, University of California San Francisco, San Francisco, CA, USA.

BACKGROUND Pituitary gland metastasis is rarely the initial presentation of metastatic cancer. Most cases of pituitary gland metastasis are asymptomatic with diabetes insipidus being the most common symptomatic presentation. It can rarely present with symptoms of hormone underproduction such as secondary adrenal insufficiency. Read More

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http://dx.doi.org/10.12659/AJCR.913388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388645PMC
February 2019
2 Reads

Targeted assessment of methylation identifies a rapidly recurrent, routinely fatal molecular subtype of adrenocortical carcinoma.

Clin Cancer Res 2019 Feb 15. Epub 2019 Feb 15.

Internal Medicine - Metabolism, Endocrinology & Diabetes, University of Michigan-Ann Arbor

Purpose: Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with few therapies; however, patients with locoregional disease have variable outcomes. The Cancer Genome Atlas project on ACC (ACC-TCGA) identified that cancers of patients with homogeneously rapidly recurrent or fatal disease bear a unique CpG island hypermethylation phenotype, "CIMP-high." We sought to identify a biomarker that faithfully captures this subgroup. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-2693DOI Listing
February 2019
1 Read

[A Case of Gastric Neuroendocrine Carcinoma with Bulky Lymph Node Metastases, Solitary Liver Metastasis, and Left Adrenal Metastasis Curatively Resected after Chemotherapy].

Gan To Kagaku Ryoho 2019 Jan;46(1):103-105

Dept. of Surgery, Osaka City Juso Hospital.

A 68-year-old man presented with generalfatigue due to anemia. Gastrointestinalendoscopy showed a tumor approximately 60mm in diameter in the lesser curvature of the angle of the stomach. Large cell neuroendocrine carcinoma was diagnosed by biopsy of a tumor specimen. Read More

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January 2019
1 Read

[Gastric Neuroendocrine Carcinoma(NEC)Treated with CDDP plus CPT-11 Chemotherapy].

Gan To Kagaku Ryoho 2019 Jan;46(1):65-69

Dept. of Digestive Surgery, Saku Central Hospital Advanced Care Center.

A 69-year-old man with chronic gastritis, reflux esophagitis, esophageal hiatal hernia, and history of appendicitis surgery complained of difficulty swallowing. Upper gastrointestinal endoscopy revealed a 10 cm sized Type 3 gastric cancer. Immunostaining was positive for chromogranin A(2+), synaptophysin(3+), CD56(-), and Ki-67>70%. Read More

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January 2019
10 Reads

Operative Management of Recurrent and Metastatic Adrenocortical Carcinoma: A Systematic Review.

Am Surg 2019 Jan;85(1):23-28

Metastatic adrenocortical carcinoma (ACC) is associated with a poor 5-year survival rate and high rate of recurrence. Outcomes after resection for patients with limited disease remain poorly described. We conducted a PubMed search for articles published between 1950 and 2017 using the terms "ACC," "recurrence," and "surgery. Read More

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January 2019
4 Reads

[Adrenal carcinoma with vena cava thrombus].

Authors:
H Dralle

Chirurg 2019 Mar;90(Suppl 2):104

Sektion Endokrine Chirurgie, Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0869-5DOI Listing

Lung Adenocarcinoma with Gingival Metastasis.

Eur J Case Rep Intern Med 2018 26;5(6):000861. Epub 2018 Jun 26.

Pneumology Department, Farhat Hached University Hospital, Sousse, Tunisia.

Gingival metastasis of lung cancer is uncommon. We report the case of an 82-year-old male smoker admitted to the pulmonology department with right pleural effusion. A chest computed tomography (CT) scan showed an invasive right hilar tumour, adherent to the superior vena cava, pulmonary artery, main right bronchus, mediastinal pleura and pericardium with lymphangitic carcinomatosis of the right lung. Read More

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http://dx.doi.org/10.12890/2018_000861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346877PMC
June 2018
2 Reads

Acromegaly associated with GIST, non-small cell lung cancer, clear cell renal cancer, myeloma multiplex, medulla oblongata tumor, adrenal adenoma and follicular thyroid nodules.

Endokrynol Pol 2019 Feb 11. Epub 2019 Feb 11.

Dept. of Endocrinology, Diabetes and Isotope Therapy, Medical University Wroclaw, Pasteura 4, 50-367 Wrocłąw, Poland.

Background: Acromegaly is associated with increased growth hormone (GH) and insulin-like growth factor-I (IGF-I) secretion which may support tumor development and growth.

Case Presentation: A 68-year old woman was diagnosed with acromegaly due to typical clinical and hormonal characteristics. While a contrast-enhanced MRI at diagnosis did not reveal a pituitary adenoma, a 5 mm lesion was identified on repeat scanning 13 months later. Read More

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http://dx.doi.org/10.5603/EP.a2019.0005DOI Listing
February 2019
6 Reads

New and Emerging Biomarkers in Endocrine Pathology.

Adv Anat Pathol 2019 Feb 5. Epub 2019 Feb 5.

Department of Pathology, Massachusetts General Hospital.

Significant advances in genomics and molecular genetics in recent years have reshaped the practice of endocrine pathology. Pan-genomic studies, including the pioneering ones on papillary thyroid carcinoma, phaeochromocytoma/paraganglioma, and adrenal cortical carcinoma from the Cancer Genome Atlas (TCGA) project, provided a comprehensive integrated genomic analysis of endocrine tumors into distinct molecularly defined subtypes. Better understanding of the molecular landscape and more accurate definition of biological behavior has been accordingly achieved. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000227DOI Listing
February 2019
2 Reads

ADRENAL CORTICAL CARCINOMA IN INFANCY.

Rev Paul Pediatr 2019 Jan-Mar;37(1):2-3

Faculdade de Ciências Médicas, Santa Casa de São Paulo, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1590/1984-0462/;2019;37;1;00021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362380PMC
October 2018

Adrenocortical carcinoma in patients with MEN1: a kindred report and review of the literature.

Endocr Connect 2019 Mar;8(3):230-238

Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai E-Institute for Endocrinology, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.

Objective Up to 40% of multiple endocrine neoplasia type 1 (MEN1) patients may have adrenal cortical tumors. However, adrenocortical carcinoma (ACC) is rare. The clinical manifestations, prevalence, inheritance and prognosis of ACC associated with MEN1 remain unclear. Read More

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http://dx.doi.org/10.1530/EC-18-0526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391906PMC
March 2019
1 Read

Depression Promotes Hepatocellular Carcinoma Progression through a Glucocorticoids Mediated Up-Regulation of PD-1 Expression in Tumor infiltrating NK Cells.

Carcinogenesis 2019 Feb 4. Epub 2019 Feb 4.

Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, China.

There is a growing belief that depression was positively associated with the progression of liver cancer. However, the driving molecular events behind the depression in liver cancer are poorly understood and need to be elucidated. Since hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis during depression leads to the excessive release of glucocorticoids (GCs), which suppress the activity of NK cells, we hypothesized that high levels of GCs during depression may inhibit function of tumor infiltrating NK cells during the progress of the liver cancer. Read More

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http://dx.doi.org/10.1093/carcin/bgz017DOI Listing
February 2019
1 Read

Unusual Metastases in Papillary Microcarcinoma of Thyroid.

Indian J Nucl Med 2019 Jan-Mar;34(1):32-34

Department of Nuclear Medicine, SVIMS, Tirupati, Andhra Pradesh, India.

Papillary carcinoma thyroid is the most common type of thyroid cancer. Papillary thyroid cancer metastasizes commonly to regional lymph nodes, distant organ involvement is to lungs and bone are rare and is associated with poor prognosis. Metastases to intra-abdominal organs are extremely rare. Read More

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http://dx.doi.org/10.4103/ijnm.IJNM_127_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352647PMC
February 2019
1 Read

Treatment and management of adrenal cancer in a specialized Australian endocrine surgical unit: approaches, outcomes and lessons learnt.

ANZ J Surg 2019 Jan 1;89(1-2):48-52. Epub 2019 Feb 1.

Cancer Genetics Laboratory, Kolling Institute, Northern Sydney Local Health District, Sydney, New South Wales, Australia.

Background: Adrenocortical carcinoma is a rare and heterogeneous malignancy with poor outcomes. Recent research has suggested that outcomes may be improved by centralization of care in specialist centres. We review our evolving 21-year experience in managing adrenocortical carcinoma with a view towards outcomes and lessons learnt. Read More

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http://dx.doi.org/10.1111/ans.15032DOI Listing
January 2019
3 Reads

Incidental retroperitoneal oncocytoma (Ectopic oncocytic adrenocortical adenoma): Case report and review of the literature.

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):132-135

Department of Radiology, Karadeniz Technical University, Trabzon, Turkey.

Ectopic adrenocortical tissue may be present in many anatomical localizations. Hyperplasia, adenoma or carcinoma can occasionally develop from the ectopic adrenal tissue. Therefore, it should be surgically excised when it is detected. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_58_18DOI Listing
February 2019
2 Reads

A Rare Presentation of Colorectal Cancer with Unusual Progressive Intramuscular and Subcutaneous Metastatic Spread.

Asia Ocean J Nucl Med Biol 2019 ;7(1):89-94

Tabriz University of Medical Sciences, Tabriz, Iran.

Colorectal carcinoma is one of the most common causes of cancer-related death, worldwide. Recently, due to the introduction of novel imaging and therapeutic techniques, five-year survival of patients has increased. However, distant metastasis is still expected in half of the patients. Read More

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http://dx.doi.org/10.22038/AOJNMB.2018.11934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352049PMC
January 2019
2 Reads

A human mode of intestinal type gastric carcinoma.

Authors:
Shaoqing Lai

Med Hypotheses 2019 Feb 14;123:27-29. Epub 2018 Dec 14.

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Electronic address:

Gastric cancer is a malignant tumor originating from the gastric mucosa epithelium. Intestinal type gastric cancer is frequently taken on elderly men, and there are many high incidence areas around the world. Intestinal type gastric cancer often is accompanied by gastric mucosal atrophy, intestinal metaplasia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03069877183121
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http://dx.doi.org/10.1016/j.mehy.2018.12.009DOI Listing
February 2019
11 Reads

Synchronous renal cell carcinoma and pheochromocytoma presenting as acute decompensated heart failure.

J Postgrad Med 2019 Jan-Mar;65(1):44-46

Division of Cardiology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

We report a 49-year-old woman who presented with a hypertensive crisis and acute heart failure and reduced left ventricular systolic function. An abdominal ultrasonography revealed a huge lobulated heterogeneous mass at the lower pole of the right kidney and a mass over the left suprarenal area, which were further delineated by magnetic resonance imaging. The patient underwent laparoscopic right radical nephrectomy and left adrenalectomy. Read More

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http://www.jpgmonline.com/text.asp?2019/65/1/44/250961
Publisher Site
http://dx.doi.org/10.4103/jpgm.JPGM_701_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380140PMC
January 2019
4 Reads

Renal and adrenal masses containing fat at MRI: Proposed nomenclature by the society of abdominal radiology disease-focused panel on renal cell carcinoma.

J Magn Reson Imaging 2019 Apr 28;49(4):917-926. Epub 2019 Jan 28.

Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.

This article proposes a consensus nomenclature for fat-containing renal and adrenal masses at MRI to reduce variability, improve understanding, and enhance communication when describing imaging findings. The MRI appearance of "macroscopic fat" occurs due to a sufficient number of aggregated adipocytes and results in one or more of: 1) intratumoral signal intensity (SI) loss using fat-suppression techniques, or 2) chemical shift artifact of the second kind causing linear or curvilinear India-ink (etching) artifact within or at the periphery of a mass at macroscopic fat-water interfaces. "Macroscopic fat" is most commonly observed in adrenal myelolipoma and renal angiomyolipoma (AML) and only rarely encountered in other adrenal cortical tumors and renal cell carcinomas (RCC). Read More

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http://dx.doi.org/10.1002/jmri.26542DOI Listing
April 2019
3 Reads

[A Patient with Multiple Pancreatic Metastases Undergoing Total Pancreatectomy 18 Years after Renal Cell Carcinoma Resection].

Gan To Kagaku Ryoho 2018 Dec;45(13):2214-2216

Dept. of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine.

A 71-year-old woman underwent right nephrectomy for the treatment of clear cell renal cell carcinoma at the age of 53. After 15 years, surgical removal of a solitary tumor was performed in the right adrenal gland and thyroid gland; both were diagnosed as metastases of renal cell carcinoma. Eighteen years after the initial resection, computed tomography(CT) showed multiple hypervascular tumors spreading across the entire area of the pancreas. Read More

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December 2018
2 Reads

Biomolecular engineering of antidehydroepiandrosterone antibodies: a new perspective in cancer diagnosis and treatment using single-chain antibody variable fragment.

Nanomedicine (Lond) 2019 Jan 29. Epub 2019 Jan 29.

Pós-graduação em Engenharia de Bioprocessos e Biotecnologia, Curitiba, Brazil.

Aim: To develop a monoclonal antibody against dehydroepiandrosterone (DHEA) and miniaturize it, generating a single-chain antibody variable fragment (scFv) against DHEA as an adrenocortical carcinoma (ACC) marker.

Material & Methods: DHEA conjugated to keyhole limpet hemocyanin was used as an immunogen to obtain anti-DHEA hybridomas. Variable fragments were cloned from hybridoma 5B7 total RNA, and used to detect DHEA in normal adrenal tissue and ACC cells. Read More

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http://dx.doi.org/10.2217/nnm-2018-0230DOI Listing
January 2019
3 Reads

Molecular Testing for EGFR Mutations and ALK Rearrangements in the Cytological Specimens From the Patients With Non-Small Cell Lung Cancer.

Appl Immunohistochem Mol Morphol 2019 Feb;27(2):119-124

Department of Pathology, Indiana University School of Medicine, Indianapolis, IN.

Objective: The aim of this study was to investigate epidermal growth factor receptor (EGFR) gene mutations and anaplastic lymphoma kinase (ALK) gene rearrangements using cytological specimens from the patients with a diagnosis of primary or metastatic lung non-small cell carcinoma.

Materials And Methods: A total 307 cases were submitted for EGFR mutational analysis and 265 cases for ALK analysis. The cytological specimen sources included lung, lymph node, liver, bone, adrenal gland, mesentery mass, and body fluids/bronchial brushing. Read More

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http://Insights.ovid.com/crossref?an=00129039-900000000-9874
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http://dx.doi.org/10.1097/PAI.0000000000000701DOI Listing
February 2019
5 Reads

A rare case of pure testosterone-secreting adrenal adenoma in a postmenopausal elderly woman.

BMC Endocr Disord 2019 Jan 23;19(1):14. Epub 2019 Jan 23.

Department of Endocrinology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, 310003, Hangzhou, China.

Background: Hyperandrogenemia is more common in puberty and reproductive age, but relatively rare in postmenopausal women. Postmenopausal virilization may result from androgen-producing tumors. Androgen-secreting adrenal tumors are rare in clinical practice and are diagnosed as adrenocortical carcinoma, most of which can co-secrete androgen and cortisol. Read More

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http://dx.doi.org/10.1186/s12902-019-0342-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343319PMC
January 2019
1 Read

Collision Tumor of Urothelial Cell Carcinoma and Clear Cell Renal Cell Carcinoma: A Case Report and Review of the Contemporary Literature.

Appl Immunohistochem Mol Morphol 2019 Jan 21. Epub 2019 Jan 21.

Department of Histopathology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.

We present a case of synchronous renal cell carcinoma and urothelial carcinoma. Our case was a true collision tumor and both components were high grade. Metastasis to the adrenal gland by the urothelial carcinoma was observed. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000728DOI Listing
January 2019
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Natural history, treatment, and long-term follow up of patients with multiple endocrine neoplasia type 2B: an international, multicentre, retrospective study.

Lancet Diabetes Endocrinol 2019 Mar 16;7(3):213-220. Epub 2019 Jan 16.

Endocrine Oncology, Institut Gustave Roussy Ecole Doctorale de Cancerologie, Villejuif, France.

Background: Multiple endocrine neoplasia type 2B is a rare syndrome caused mainly by Met918Thr germline RET mutation, and characterised by medullary thyroid carcinoma, phaeochromocytoma, and extra-endocrine features. Data are scarce on the natural history of multiple endocrine neoplasia type 2B. We aimed to advance understanding of the phenotype and natural history of multiple endocrine neoplasia type 2B, to increase awareness and improve detection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22138587183033
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http://dx.doi.org/10.1016/S2213-8587(18)30336-XDOI Listing
March 2019
10 Reads

Seminal vesicle metastasis after liver transplantation for hepatocellular carcinoma: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e13770

Department of Gastroenterology, The Affiliated Drum Tower Hospital of Nanjing University, Medical School.

Rationale: Cancer recurrence and metastasis after liver transplantation (LT) is common in some hepatocellular carcinoma (HCC) patients. The most common sites of extrahepatic metastases are lung, regional lymph node, adrenal gland, and bone. To our knowledge, HCC metastasis to the seminal vesicle after LT has not been reported in the literature. Read More

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http://dx.doi.org/10.1097/MD.0000000000013770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370123PMC
January 2019
2 Reads

Alterations in the glycome after HDAC inhibition impact oncogenic potential in epigenetically plastic SW13 cells.

BMC Cancer 2019 Jan 16;19(1):79. Epub 2019 Jan 16.

Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Glendale, AZ, 85308, USA.

Background: Defects in the type and degree of cellular glycosylation impact oncogenesis on multiple levels. Although the type of glycosylation is determined by protein sequence encoded by the genome, the extent and modifications of glycosylation depends on the activity of biosynthetic enzymes and recent data suggests that the glycome is also subject to epigenetic regulation. This study focuses on the ability of HDAC inhibition to alter glycosylation and to lead to pro-oncogenic alterations in the glycome as assessed by metastatic potential and chemoresistance. Read More

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http://dx.doi.org/10.1186/s12885-018-5129-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335691PMC
January 2019
2 Reads

MDR1 inhibition increases sensitivity to doxorubicin and etoposide in adrenocortical cancer.

Endocr Relat Cancer 2019 Jan 1. Epub 2019 Jan 1.

L Hofland, Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

Chemotherapy for adrenocortical carcinoma (ACC) has limited efficacy and is accompanied by severe toxicity. This lack of effectiveness has been associated with high tumoral levels of the multidrug resistance (MDR) pump P-glycoprotein (P-gp), encoded by the MDR1 gene. In this study, effects of P-gp inhibition on sensitivity of ACC cells to cytotoxic drugs were evaluated. Read More

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http://dx.doi.org/10.1530/ERC-18-0500DOI Listing
January 2019
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Familial and Hereditary Forms of Primary Hyperparathyroidism.

Front Horm Res 2019 19;51:40-51. Epub 2018 Nov 19.

Individuals with a familial predisposition to the development of parathyroid tumors constitute a small minority of all patients with primary hyperparathyroidism (PHPT). These familial syndromes exhibit Mendelian inheritance patterns and the main causative genes in most families have been identified. They include multiple endocrine neoplasia (MEN; types 1, 2A, and 4), hyperparathyroidism-jaw tumor (HPT-JT) syndrome, familial isolated hyperparathyroidism, familial hypocalciuric hypercalcemia (FHH), and neonatal severe PHPT. Read More

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https://www.karger.com/Article/FullText/491037
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http://dx.doi.org/10.1159/000491037DOI Listing
November 2018
3 Reads