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    1 OF 181

    Jejunal metastasis of renal cell carcinoma.
    Rev Esp Enferm Dig 2017 Feb;109(2):147-148
    Aparato Digestivo, Complejo Hospitalario Universitario de Vigo.
    A 71-year-old female presented with melena and anemia. She had a past medical history of renal cell carcinoma diagnosed six years earlier and treated with left nephrectomy. Gastroscopy and colonoscopy showed no abnormalities. Read More

    Tumor-associated neutrophils and macrophages promote gender disparity in hepatocellular carcinoma in zebrafish.
    Cancer Res 2017 Feb 15. Epub 2017 Feb 15.
    Department of Biological Sciences, National University of Singapore
    Hepatocellular carcinoma (HCC) occurs more frequently and aggressively in men than women, but the mechanistic basis of this gender disparity is obscure. Chronic inflammation is a major etiological factor in HCC, so we investigated the role of cortisol in gender discrepancy in a zebrafish model of HCC. Inducible expression of oncogenic KrasV12 in hepatocytes of transgenic zebrafish resulted in accelerated liver tumor progression in males. Read More

    Mixed corticomedullary adrenal carcinoma - case report: Comparison in features, treatment and prognosis with the other two reported cases.
    Int J Surg Case Rep 2017 Jan 31;31:254-261. Epub 2017 Jan 31.
    Alberoni Hospital, Damascus University Faculty of Medicine, P.O. Box: 60527, Damascus, Syria. Electronic address:
    Introduction: Adrenal corticomedullary adenoma was reviewed in many cases in PubMed Library, While the coincidence corticomedullary adrenal carcinoma in the same gland was just described in two cases in the medical literature. Our case is the third to be reported and was treated with surgery and adjuvant chemotherapy and followed for two years.

    Presentation Of Case: A 50-year-old man suffered from a mass effect in the left abdominal side. Read More

    European Society of Endocrine Surgeons (ESES) and European Network for the Study of Adrenal Tumours (ENSAT) recommendations for the surgical management of adrenocortical carcinoma.
    Br J Surg 2017 Mar;104(4):358-376
    Churchill Cancer Centre, Oxford University Hospitals Foundation Trust, Oxford, UK.
    Background: Radical surgery provides the best chance of cure for adrenocortical carcinoma (ACC), but perioperative surgical care for these patients is yet to be standardized.

    Methods: A working group appointed jointly by ENSAT and ESES used Delphi methodology to produce evidence-based recommendations for the perioperative surgical care of patients with ACC. Papers were retrieved from electronic databases. Read More

    New insights and future perspectives in the therapeutic strategy of adrenocortical carcinoma (Review).
    Oncol Rep 2017 Mar 7;37(3):1301-1311. Epub 2017 Feb 7.
    Endocrinology, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Faculty of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, Italy.
    Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with an incidence ranging from 0.7 to 2.0 cases/million people per year. Read More

    Appearance of a thymic mass after treatment of Cushing's syndrome.
    Asian Cardiovasc Thorac Ann 2017 Feb 19;25(2):150-153. Epub 2016 Dec 19.
    1 Internal Medicine Unit, University Hospital of Sassari, Sassari, Italy.
    A 23-year-old woman was referred to our center with hirsutism, acne, weight gain, weakness, and irregular menses. Laboratory tests revealed increased levels of cortisol and sex hormones, and reduced adrenocorticotropic hormone levels. The patient underwent a right adrenalectomy. Read More

    Recommendations For The Management Of Adrenal Incidentalomas: What is pertinent for Radiologists?
    Br J Radiol 2017 Feb 9:20160627. Epub 2017 Feb 9.
    1 Department of Imaging, St Bartholomew's Hospital, Barts Health NHS Trust, London UK EC1A 7BE.
    Adrenal incidentalomas are unsuspected, asymptomatic adrenal masses detected on imaging. Most are non-functioning benign adrenocortical adenomas, but can represent other benign lesions or lesions requiring therapeutic intervention including adrenocortical carcinoma, pheochromocytoma, hormone-producing adenoma or metastasis. This review summarises and highlights radiological recommendations within the recently issued guidelines for the management of adrenal incidentalomas from European Society of Endocrinology Clinical Practice in collaboration with European Network for Study of Adrenal Tumours. Read More

    Cushing's Syndrome in Children and Adolescents: A Danish Nationwide Population-Based Cohort Study.
    Eur J Endocrinol 2017 Feb 8. Epub 2017 Feb 8.
    J Jorgensen, Department of Internal Medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark.
    Objective: Cushing's syndrome (CS) affects all age groups, but epidemiologic data in young pa-tients are very limited. We therefore examined the incidence, prevalence, and hospital morbidity of CS in children and adolescents.

    Design: In a nationwide cohort study we included all Danish citizens aged 0-20 years from 1977 to 2012. Read More

    Retro-orbital, Breast, Cardiac, Skin, and Subcutaneous Metastases of Neuroendocrine Tumor From a Tail Gut Cyst on 68Ga-DOTATATE PET/CT Imaging.
    Clin Nucl Med 2017 Feb 3. Epub 2017 Feb 3.
    From the *Department of Nuclear Medicine, School of Medicine, Dokuz Eylül University, Izmir; and †Department of Pathology, School of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey.
    Tail gut cysts are rare congenital lesions developing from postanal primitive gut remnants. They are mostly benign but carry a potential of malignant transformation, such as adenocarcinoma, neuroendocrine tumor, adenosquamous carcinoma, and pseudomyxoma peritonei. We present a 39-year-old woman with a neuroendocrine tumor arising within a tail gut cyst. Read More

    Chylous ascites after resection of giant adrenocortical carcinoma.
    Gland Surg 2016 Dec;5(6):639-643
    Pathology Department, Antalya Training and Research Hospital, Antalya, Turkey.
    Postoperative chylous ascites (PCA) is a rare clinical state that occurs during abdominal surgery. Despite its rarity, the need to diagnose and treat PCA is increasing in importance with the increased number of wide resections and lymph node dissections being performed and the serious consequences of treatment. Here we describe the PCA complications we observed after resection for treating a case of giant adrenocortical carcinoma and we have the brief review of the PCA complication. Read More

    Multiple Endocrine Neoplasia Type 2B Unmasked by 18F-FDG PET/CT and 131I-MIBG SPECT/CT.
    Clin Nucl Med 2017 Jan 27. Epub 2017 Jan 27.
    From the Department of Nuclear Medicine, and Hubei Province Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
    F-FDG PET/CT was performed to detect an occult malignancy in a 26-year-old woman with complicated medical history which included paroxysmal hypertension and significantly elevated tumor marker. The images revealed lesions in the thyroid, lymph nodes, and bilateral adrenal glands. Further I-MIBG SPECT/CT revealed intense activity in the lesion in the left adrenal gland, which was consistent with pheochromocytoma. Read More

    [A Case of Recurrent Breast Cancer with Adrenal Metastasis Resected Using Laparoscopic Surgery].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2035-2037
    Dept. of Surgery, National Hospital Organization Osaka National Hospital.
    We report a case of recurrent breast cancer with involvement of the right adrenal grand, which was resected using laparoscopic surgery. The patient was a 41-year-old woman who underwent duct-lobular segmentectomy for ductal carcinoma in situ. Histopathology showed microinvasion, and tested positive for ER and PR, but negative for HER2, so we applied radiation to the remaining breast and administered tamoxifen. Read More

    [Resection of Hepatocellular Carcinoma with Synchronous Bilateral Adrenal Metastases].
    Gan To Kagaku Ryoho 2016 Nov;43(12):1770-1772
    Dept. of Surgery, Toyonaka Municipal Hospital.
    A 59-year-old man was admitted to our hospital with liver dysfunction. Examinations revealed a huge liver tumor in the right hepatic lobe and a mass in each adrenal gland. The preoperative diagnosis was hepatocellular carcinoma(HCC)with synchronous bilateral adrenal metastases. Read More

    [Resection of Adrenal Metastasis after Chemotherapy and Radiation Therapy for a Patient with Stage IV B Hepatocellular Carcinoma].
    Gan To Kagaku Ryoho 2016 Nov;43(12):1594-1596
    Dept. of Surgery, Tokyo Metropolitan Bokutoh Hospital.
    In the treatment of hepatocellular carcinoma, atypical, off guideline multidisciplinary approaches are sometimes effective. A 70-year-old man was diagnosed with multiple hepatocellular carcinomas, multiple bone metastases, and a right adrenal metastasis. Sunitinib was started and the primary hepatic lesions and bone metastases disappeared. Read More

    Metachronous solitary metastasis to the thyroid gland from squamous cell carcinoma of the lung: a case report and literature review.
    Tumori 2017 Jan 23. Epub 2017 Jan 23.
     Medical Oncology Unit, Policlinico S. Orsola-Malpighi, Bologna - Italy.
    Introduction: Non-small cell lung cancer presents at an advanced stage at diagnosis in two-thirds of cases. The most frequent metastatic sites are the central nervous system, adrenal glands and bones. By contrast, the thyroid gland is an extremely rare site of dissemination. Read More

    Bilateral Aldosterone-Producing Adrenocortical Carcinoma: a Rare Entity.
    Indian J Surg Oncol 2017 Mar 18;8(1):88-90. Epub 2016 Oct 18.
    Minimal Invasive Urology, Department of Urology and Kidney Transplant, Medanta, The Medicity, Gurgaon, Haryana 122001 India.
    Adrenal cortical carcinomas (ACC) are rare aggressive malignant neoplasms with a reported incidence of 1-2 cases per 1 million population and account for 0.05-0.2 % of all malignancies. Read More

    Management of Adrenal Masses.
    Indian J Surg Oncol 2017 Mar 17;8(1):67-73. Epub 2016 Dec 17.
    Department of Urology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Amrita lane elmakkara, Kochi, Kerala 682041 India.
    An adrenal mass can be either symptomatic or asymptomatic in the form of adrenal incidentalomas (AIs) in up to 8 % in autopsy and 4 % in imaging series. Once a diagnosis of adrenal mass is made, we need to differentiate whether it is functioning or nonfunctioning, benign, or malignant. In this article, we provide a literature review of the diagnostic workup including biochemical evaluation and imaging characteristics of the different pathologies. Read More

    Practical Approach to Adrenal Imaging.
    Radiol Clin North Am 2017 Mar 12;55(2):279-301. Epub 2016 Dec 12.
    Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street Unit 1473, Houston, TX 77030, USA.
    Various pathologies can affect the adrenal gland. Noninvasive cross-sectional imaging is used for evaluating adrenal masses. Accurate diagnosis of adrenal lesions is critical, especially in cancer patients; the presence of adrenal metastasis changes prognosis and treatment. Read More

    Predicting malignancy in adrenal incidentaloma and evaluation of a novel risk stratification algorithm.
    ANZ J Surg 2017 Jan 24. Epub 2017 Jan 24.
    Endocrine Surgical Unit, The University of Sydney, Sydney, New South Wales, Australia.
    Background: Incidentally discovered adrenal lesions known as adrenal incidentalomas (AI) are being encountered with increasing frequency due to the widespread use of abdominal computed tomography (CT). The aim of this study was to identify the clinical predictors of malignancy in AI and to evaluate the accuracy of a recently proposed risk stratification algorithm.

    Methods: A retrospective analysis of 96 patients presenting with AI between 2004 and 2014 was undertaken; 66 patients underwent adrenalectomy, and 30 were managed non-operatively. Read More

    RARRES2 functions as a tumor suppressor by promoting β-catenin phosphorylation/degradation and inhibiting p38 phosphorylation in adrenocortical carcinoma.
    Oncogene 2017 Jan 23. Epub 2017 Jan 23.
    Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
    Tumor suppressor genes and the immune system are critical players in inhibiting cancer initiation and/or progression. However, little is known about whether a tumor suppressor gene can function through both immune-dependent and -independent mechanisms. Retinoic acid receptor responder 2 (RARRES2) is transcriptionally downregulated in multiple cancer types. Read More

    A Case Report of Bilateral Adrenal Sarcomatoid Carcinoma.
    Case Rep Surg 2016 20;2016:3768258. Epub 2016 Dec 20.
    Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey.
    Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy. Sarcomatoid adrenal carcinoma is even more aggressive type of ACC. Bilateral malignant adrenal tumors are extremely rare except for those that represent metastasis from an extra-adrenal organ. Read More

    PURE ANDROGEN-PRODUCING ADRENAL TUMOR: CLINICAL FEATURES AND PATHOGENESIS.
    Endocr Pract 2017 Jan 17. Epub 2017 Jan 17.
    From: 1Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences, Beijing 100730, China.
    Objective: Pure androgen-secreting adrenal tumors (PASATs) are extremely rare, most reports involving only a single case. This study examined 9 cases of PASAT, with an attempt to characterize its clinical features and to explore their possible pathogenesis.

    Methods: Clinical data of 9 patients with PASAT were retrospectively reviewed. Read More

    Immunohistochemical features of giant cell ependymoma of the filum terminale with unusual clinical and radiological presentation.
    Diagn Pathol 2017 Jan 14;12(1). Epub 2017 Jan 14.
    Department of Pathology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
    Background: Giant cell ependymoma of the filum terminale is a rare variant, generally manifested as a well-circunscribed intradural mass with an indolent biological behavior.

    Case Presentation: We describe the case of a 48-year-old Mexican female who non-relevant past medical history, that developed a GCE of the filum terminale. Magnetic resonance imaging and computed tomography revealed the presence of an intra-axial tumor extending from L3 to L5 with extra-medullary invasion. Read More

    Immunohistochemical Approach for the Diagnosis of a Liver Mass on Small Biopsy Specimens.
    Hum Pathol 2017 Jan 10. Epub 2017 Jan 10.
    Department of Pathology, University of California at San Francisco, San Francisco, CA 94143.
    Well-differentiated hepatocellular carcinoma (HCC) shares overlapping histological features with benign hepatocellular lesions, including hepatocellular adenoma (HCA) and focal nodular hyperplasia (FNH) in non-cirrhotic liver, and with high-grade dysplastic nodule (HGDN) in cirrhotic liver. Several metastatic tumors, such as neuroendocrine tumor, renal cell carcinoma, adrenocortical carcinoma, melanoma, and epithelioid angiomyolipoma, can be indistinguishable from HCC on histologic grounds. Since this distinction has important therapeutic implications, judicious use of immunohistochemical markers plays an important role in establishing an accurate diagnosis, especially when limited material of tumor is available on cell block or a small core biopsy. Read More

    Oral and vulvo-vaginal lichenoid reactions due to mitotane (Lysodren): A case report.
    Medicine (Baltimore) 2017 Jan;96(2):e5075
    aDepartment of Dental Surgery bDepartment of Endocrinology, Brest University Hospital, Brest cDepartment of Dermatology, Quimper Hospital, Quimper dDepartment of Oral Surgery, Brest University Hospital, Brest, France.
    Background: The purpose of pharmacovigilance (drug safety) is collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products. It is meant to identify, characterize, prevent, or minimize actual or potential risks relating to medicinal products. To prevent these adverse effects and improve our practice, health professionals have a duty to report side effects to assess this risk and evaluate the benefit/risk requirements. Read More

    Delineating Extramammary Findings at Breast MR Imaging.
    Radiographics 2017 Jan-Feb;37(1):10-31
    From the Department of Radiology, New York University-Langone Medical Center, 160 E 34th St, New York, NY 10016 (Y.G., O.I., H.K.T., L.M.); and the Center for Advanced Imaging Innovation and Research, New York University School of Medicine, New York, NY (L.M.).
    Breast magnetic resonance (MR) imaging is the only breast imaging modality that consistently encompasses extramammary structures in the thorax and upper abdomen. Incidental extramammary findings on breast MR images of patients with a history of breast cancer or other malignancies are significantly more likely to be malignant and may affect staging and treatment. An understanding of the frequency, distribution, and context of extramammary findings on breast MR images and a familiarity with common and uncommon sites of breast cancer metastasis inform the differential diagnosis and prompt the appropriate diagnostic next step, to differentiate benign from malignant findings. Read More

    Diagnostic value of additional (68)Ga-PSMA-PET before (223)Ra-dichloride therapy in patients with metastatic prostate carcinoma.
    Nuklearmedizin 2017 Feb 11;56(1):14-22. Epub 2017 Jan 11.
    Axel Bräuer, Department of Nuclear Medicine,, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149 Münster, Germany, Phone: +49 251 8347362, Fax: +49 251 8347363, E-Mail:
    Purpose: Medical imaging plays an important role in selecting patients with metastatic castration-resistant prostate cancer for (223)Ra-dichloride therapy of bone metastases. The purpose of this study was to investigate whether (68)Ga-PSMA-PET has incremental value over conventional imaging for selecting patients suitable for (223)Ra-dichloride therapy.

    Methods: In 27 consecutive patients referred for (223)Ra-dichloride therapy additional (68)Ga-PSMA-PET/CT was performed and tracer distribution was evaluated systematically with respect to the detection of visceral metastases and bone metastases with inadequate uptake on bone scintigraphy. Read More

    Overexpression of cytochrome P450 2A6 in adrenocortical carcinoma.
    Surgery 2017 Jan 7. Epub 2017 Jan 7.
    Yale Department of Surgery & Yale Endocrine Neoplasia Laboratory, Yale School of Medicine, New Haven, CT. Electronic address:
    Background: Cytochrome P450-mediated metabolism of chemotherapeutic agents contributes to chemotherapy resistance in multiple malignancies. Adrenocortical carcinoma is known to have a poor response to adjuvant therapies; however, the mechanism remains unknown. Recent comprehensive genetic analyses of adrenocortical carcinomas demonstrated recurrent copy number gains in multiple cytochrome P450 genes prompting investigation into whether cytochrome P450 overexpression potentiates adrenocortical carcinoma chemoresistance. Read More

    Adrenocortical carcinoma in children and adults: Two decades experience in a single institution.
    Indian J Cancer 2016 Apr-Jun;53(2):317-321
    Department of Endocrine Surgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
    Context: Adrenocortical carcinoma (ACC) occurring in children and adults show distinct characteristics. However, due to rarity of the disease no large series addressing this issue has been published.

    Aims: The aim of this study was to study clinico-pathologic profile and outcome of ACC in children and adults. Read More

    Lung adenocarcinoma and adrenocortical carcinoma in a patient with multiple endocrine neoplasia type 1.
    Respir Med Case Rep 2017 18;20:77-81. Epub 2016 Dec 18.
    Department of Internal Medicine, Ojiya General Hospital, Niigata, Japan; Center of Diabetes, Endocrinology and Metabolism, Joetsu General Hospital, Niigata, Japan.
    Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder caused by heterozygous germline mutations in the tumor suppressor gene MEN1, which encodes a nuclear protein, menin. MEN1 is characterized by the combined occurrence of tumors involving the pituitary gland, pancreatic islets, and parathyroid glands. Additionally, patients with MEN1 often exhibit adrenal tumors. Read More

    Long-term control of hypercortisolism by vandetanib in a medullary thyroid carcinoma with a somatic RET mutation.
    Thyroid 2017 Jan 9. Epub 2017 Jan 9.
    Cochin Institute, Endocrinology, Metabolism, Diabetes, Paris, France.
    Context: Medullary thyroid carcinomas (MTCs) complicated by ectopic Cushing's syndrome have a poor prognosis, partially due to the difficulties to control hypercortisolism by adrenal blocking drugs. Recent reports (including the initial follow-up of this patient) have suggested that tyrosine kinase inhibitors (TKIs) may be a therapeutic option due to an antisecretory action on ACTH. However, there is a lack of long-term follow-up studies. Read More

    Nonfunctioning Adrenocortical Carcinoma in Pediatric Acute Lymphoblastic Leukemia: A Case Report of a Rare Multiple Primaries Combination.
    J Pediatr Hematol Oncol 2017 Mar;39(2):150-152
    *Research Department ‡Pediatric Oncology Department ∥Pathology Department, Children's Cancer Hospital Egypt §National Cancer Institute, Cairo University ¶Cairo University Hospitals †Armed Forces College of Medicine-Egypt (AFCM), Cairo, Egypt #Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Childhood adrenocortical carcinoma (ACC) is a rare tumor and its association with acute lymphoblastic leukemia (ALL) is even rarer. One such case is discussed in this case report. A 3-year-old patient was concomitantly diagnosed with ALL and an initially nonmetastatic ACC. Read More

    Anti-NXP2-Positive Paraneoplastic Dermatomyositis With Histopathologic Changes Confined to the Acrosyringia.
    Am J Dermatopathol 2017 Jan;39(1):e3-e7
    Departments of*Dermatology, †Immunology, and ‡Pathology, Fundación Jimenez Diaz, Universidad Autónoma, Madrid, Spain.
    Background: Paraneoplastic syndromes consist of a group of disorders that are not related to the extension of the primary tumor or its metastases and that might be the first manifestation of a hidden neoplasm. It is a well-known association between dermatomyositis (DM) and cancer, especially gynecological tumors in women and lung cancer in men.

    Methods: We describe the case of a 67-year-old male who developed muscular weakness and pruritic skin lesions. Read More

    Transarterial embolization/chemoembolization therapy for hepatocellular carcinoma fed by adrenal artery: Preliminary results.
    Medicine (Baltimore) 2016 Dec;95(52):e5762
    aDepartment of Radiology, Gaochun People's Hospital, Gaochun bDepartment of Radiology and Interventional Radiology, Li shui Central Hospital, Li shui cDepartment of Interventional Radiology, The Second People's Hospital of Changzhou dDepartment of Interventional Radiology, The First People's Hospital of Changzhou, Changzhou, China.
    To assess the value of transarterial embolization/chemoembolization (TAE/TACE) therapy via adrenal artery for patients with hepatocellular carcinoma (HCC). Patients with HCC who underwent TAE/TACE therapy via adrenal artery between May 2003 and October 2015 across 4 medical centers were identified. Clinical information, procedural data, and imaging data were analyzed to assess technical success, disease control, and survival rates. Read More

    Splenorenal Arterial Bypass: Description of Technique and Case Example in an Instance of Renal Revascularization during Adrenalectomy for Adrenocortical Carcinoma.
    Int J Angiol 2016 Dec 28;25(5):e89-e92. Epub 2015 Jan 28.
    Department of Transplant Surgery, Hofstra North Shore-Long Island Jewish School of Medicine, Manhasset, New York.
    We present a patient with a 16 cm adrenocortical carcinoma that underwent a left adrenalectomy en bloc with resection of the involved segment of the left renal artery. A splenectomy and splenorenal bypass was performed to revascularize the left kidney. To our knowledge, this is the first instance in the literature of a splenorenal arterial bypass being reported for renal revascularization during an extirpative oncologic procedure. Read More

    Livin/BIRC7 expression as malignancy marker in adrenocortical tumors.
    Oncotarget 2016 Dec 21. Epub 2016 Dec 21.
    Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital of Wuerzburg, Germany.
    Livin/BIRC7 is a member of the inhibitors of apoptosis proteins family, which are involved in tumor development through the inhibition of caspases. Aim was to investigate the expression of livin and other members of its pathway in adrenocortical tumors and in the adrenocortical carcinoma (ACC) cell line NCI-H295R.The mRNA expression of livin, its isoforms α and β, XIAP, CASP3 and DIABLO was evaluated by qRT-PCR in 82 fresh-frozen adrenal tissues (34 ACC, 25 adenomas = ACA, 23 normal adrenal glands = NAG). Read More

    Curative Surgical Resection of Adrenocortical Carcinoma: Determining Long-term Outcome Based on Conditional Disease-free Probability.
    Ann Surg 2017 Jan;265(1):197-204
    *Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD †Department of Surgery, Stanford University School of Medicine, Stanford, CA ‡Department of Surgery, Emory University, Atlanta, GA §Department of Surgery, Medical College of Wisconsin, Milwaukee, WI ¶Department of Surgery, New York University School of Medicine, New York, NY ||Department of Surgery, The Ohio State University, Columbus, OH **Department of Surgery, Washington University School of Medicine, St. Louis, MO ††Department of General Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI ‡‡Department of Surgery, University of California San Diego, San Diego, CA §§Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX ¶¶Department of Surgery, University of California San Francisco, San Francisco, CA ||||Department of Surgery, Vanderbilt University, Nashville, TN ***Department of Surgery, Wake Forest School of Medicine, Winston-Salem, NC.
    Objective: To evaluate conditional disease-free survival (CDFS) for patients who underwent curative intent surgery for adrenocortical carcinoma (ACC).

    Background: ACC is a rare but aggressive tumor. Survival estimates are usually reported as survival from the time of surgery. Read More

    The role of microRNAs in the pathophysiology of adrenal tumors.
    Mol Cell Endocrinol 2016 Dec 20. Epub 2016 Dec 20.
    Cancer Genetics Laboratory, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia; Sydney Medical School Northern, Royal North Shore Hospital, University of Sydney, Australia; University of Sydney Endocrine Surgery Unit, Royal North Shore Hospital, Sydney, St Leonards, Sydney, NSW, Australia. Electronic address:
    MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression in a sequence-specific manner. Due to its association with an assortment of diseases, miRNAs have been extensively studied in the last decade. In this review, the current understanding of the role of miRNAs in the pathophysiology of adrenal tumors is discussed. Read More

    FDG PET/CT in Carcinoma of the Tongue With Bilateral Adrenal Metastases.
    Clin Nucl Med 2017 Feb;42(2):123-124
    From the Departments of *Nuclear Medicine, and †Otolaryngology and Rhinology, All India Institute of Medical Sciences, New Delhi, India.
    Squamous cell carcinoma is the most common malignant neoplasm of the oral cavity, and it contributes approximately 90% of all oral malignancies. We present a case of a squamous cell carcinoma of the tongue with rare site of bilateral adrenal metastases on F-FDG PET/CT with response evaluation after chemotherapy. Read More

    Robotic assisted adrenalectomy: Is it ready for prime time?
    Investig Clin Urol 2016 Dec 30;57(Suppl 2):S130-S146. Epub 2016 Nov 30.
    Department of Urology, Changi General Hospital, Singapore.
    Adrenal surgery is undergoing continuous evolution and minimally invasive surgery is increasingly being used for the surgical management of adrenal masses. With robotic-assisted surgery being a widely accepted surgical treatment for many urological conditions such as prostate carcinoma and renal cell carcinoma, the use of the robot has been expanded to include robotic-assisted adrenalectomy, offering an alternative minimally invasive platform for adrenal surgery. We performed a literature review on robotic-assisted adrenalectomy, reviewing the current surgical techniques and perioperative outcomes. Read More

    Anesthetic Management of Clinically Silent Familial Pheochromocytoma with MEN 2A: A Report of Four Cases.
    Indian J Surg 2016 Oct 15;78(5):414-417. Epub 2016 Aug 15.
    Department of Anesthesia, V.M.M.C. and Safdarjung Hospital, A7/14 Mianwali Nagar Paschim Vihar, New Delhi, 110087 India.
    Familial pheochromocytomas are commonly associated with multiple endocrine neoplasia type 2 (MEN 2) syndrome. Majority of the patients present with normal clinical and biochemical parameters in the preoperative period, the incidence of hypertension being only 50 %. Even though patients may be clinically asymptomatic, surveillance and proper preoperative evaluation is important, as surgery for associated tumors may precipitate a hypertensive crisis and result in severe complications. Read More

    Calcifying nested stromal-epithelial tumor (CNSET) of the liver in Beckwith-Wiedemann syndrome.
    Eur J Med Genet 2017 Feb 10;60(2):136-139. Epub 2016 Dec 10.
    Emory University School of Medicine, Department of Pathology, Atlanta, GA 30332, USA. Electronic address:
    Calcifying nested stromal-epithelial tumor (CNSET) is a rare neoplasm. In the 31 reported cases, CNSET is predominantly found in young girls and women. Beckwith-Wiedemann syndrome (BWS) (OMIM #130650) is an overgrowth syndrome with an increased risk to develop cancer. Read More

    Outcome and prognostic factors in high-risk childhood adrenocortical carcinomas: A report from the European Cooperative Study Group on Pediatric Rare Tumors (EXPeRT).
    Pediatr Blood Cancer 2016 Dec 13. Epub 2016 Dec 13.
    Department of Pediatric, Adolescent, Young Adult Oncology, French Pediatric Rare Tumor group (groupe Fracture), Institut Curie, Paris, France.
    Objectives: The aim of this retrospective international analysis was to evaluate the role of risk factors in pediatric patients with adrenocortical carcinoma (ACC) observed in European countries (2000-2013) in an attempt to identify factors associated with poor prognosis.

    Procedures: Data were retrieved from databases of Germany, France, Poland, and Italy, which form the European Cooperative Study Group on Pediatric Rare Tumors (EXPeRT). Patients were less than 18 years old, with at least one of the following tumor-related risk factors: metastases, volume more than 200 cm(3) , Cushing syndrome, vascular or regional lymph node invasion, initial biopsy, or incomplete excision. Read More

    Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma.
    Case Rep Endocrinol 2016 10;2016:5731417. Epub 2016 Nov 10.
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    Nonislet cell tumor hypoglycemia (NICTH) is a rare but serious paraneoplastic syndrome in which a tumor secretes incompletely processed precursors of insulin-like growth factor-II (IGF-II), causing hypoglycemia. Here, we report an exceptional case of NICTH caused by nonfunctioning adrenocortical carcinoma in a 39-year-old male with recurrent hypoglycemia. The patient's serum IGF-II/IGF-I ratio had increased to 27. Read More

    Cell signaling pathways in the adrenal cortex: Links to stem/progenitor biology and neoplasia.
    Mol Cell Endocrinol 2016 Dec 8. Epub 2016 Dec 8.
    Cancer Biology Graduate Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI 48109, USA; Endocrine Oncology Program, Comprehensive Cancer Center, University of Michigan Health System, 109 Zina Pitcher Place, 1528 BSRB, Ann Arbor, MI 48109, USA. Electronic address:
    The adrenal cortex is a dynamic tissue responsible for the synthesis of steroid hormones, including mineralocorticoids, glucocorticoids, and androgens in humans. Advances have been made in understanding the role of adrenocortical stem/progenitor cell populations in cortex homeostasis and self-renewal. Recently, large molecular profiling studies of adrenocortical carcinoma (ACC) have given insights into proteins and signaling pathways involved in normal tissue homeostasis that become dysregulated in cancer. Read More

    Evaluation of kidney motion and target localization in abdominal SBRT patients.
    J Appl Clin Med Phys 2016 Nov 8;17(6):6406. Epub 2016 Nov 8.
    Sunnybrook Odette Cancer Centre.
    The purpose of this study was to evaluate bilateral kidney and target translational/rotational intrafraction motion during stereotactic body radiation therapy treatment delivery of primary renal cell carcinoma and oligometastatic adrenal lesions for patients immobilized in the Elekta BodyFIX system. Bilateral kidney motion was assessed at midplane for 30 patients immobilized in a full-body dual-vacuum-cushion system with two patients immobilized via abdominal compression. Intrafraction motion was assessed for 15 patients using kilovoltage cone-beam computed tomography (kV-CBCT) datasets (n = 151) correlated to the planning CT. Read More

    Adrenalectomy for Cushing's syndrome: do's and don'ts.
    J Med Life 2016 Oct-Dec;9(4):334-341
    "I. Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Endocrinology, Clinical County Hospital, Cluj-Napoca, Romania.
    Aim. To present specific aspects of adrenalectomy for Cushing's syndrome (CS) by introducing well established aspects ("do's") and less known aspects ("don'ts"). Material and Method. Read More

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