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    1 OF 183

    Oncocytic adrenocortical carcinoma: a rare adrenal tumor subtype.
    Can J Urol 2017 Jun;24(3):8865-8867
    Department of Urology, Saint John Regional Hospital, Saint John, New Brunswick, Canada.
    Oncocytic tumors arising from the adrenal gland are rare. Oncocytic adrenal neoplasms (OAN) may mimic adrenocortical carcinoma (ACC) at presentation, and can only be definitively diagnosed histologically. Most OANs are benign, and carry a favorable prognosis. Read More

    [Adrenal surgery : Multidisciplinarity is mandatory].
    Rev Med Suisse 2017 Jun;13(567):1253-1257
    Service de chirurgie viscérale, CHUV, 1011 Lausanne.
    Adrenal tumours are rare and their management is challenging. Every patient presenting with adrenal mass or symptoms of hormones hypersecretion should be investigated. The two important questions to be answered are : 1. Read More

    Suppression of Forkhead Box Protein O1 (FOXO1) Transcription Factor May Promote Adrenocortical Tumorigenesis.
    Horm Metab Res 2017 Jun 22. Epub 2017 Jun 22.
    Yale Endocrine Neoplasia Laboratory, Yale School of Medicine, New Haven, Connecticut, USA.
    Despite recent comprehensive genetic analyses, molecular evidence for a pathophysiological continuum linking benign adrenocortical adenoma (ACA) and highly aggressive adrenocortical carcinoma (ACC) is still elusive. Using human tumor samples and the established ACC cell line SW-13, this study investigated potential regulatory roles for FOXO transcription factors, in modulating adrenocortical tumorigenesis. Adrenocortical tumor specimens (20 ACAs, 10 ACCs, and 9 normal adrenal tissue samples) obtained from 30 patients were analyzed for ubiquitously expressed FOXO transcription factors, FOXO1 and FOXO3 using qRT-PCR and immunohistochemistry. Read More

    Cushing Syndrome: Diagnostic Workup and Imaging Features, With Clinical and Pathologic Correlation.
    AJR Am J Roentgenol 2017 Jul;209(1):19-32
    1 Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030.
    Objective: Cushing syndrome (CS) is a constellation of clinical signs and symptoms resulting from chronic exposure to excess cortisol, either exogenous or endogenous. Exogenous CS is most commonly caused by administration of glucocorticoids. Endogenous CS is subdivided into two types: adrenocorticotropic hormone (ACTH) dependent and ACTH independent. Read More

    18F-FDG Uptake in Benign Fibrous Histiocytoma of Adrenal Gland: A Potential Pitfall.
    Clin Nucl Med 2017 Jun 19. Epub 2017 Jun 19.
    From the *Nuclear Medicine Centre, and †Cancer Centre, Sunway Medical Centre, Selangor, Malaysia.
    A 47-year-old man with newly diagnosed nasopharyngeal carcinoma underwent staging F-FDG PET/CT. Apart from showing increased FDG uptake in the primary site and locoregional nodal and liver metastases, an unusual site of intense FDG focus was demonstrated in the left adrenal gland. He underwent CT-guided biopsy, and the histopathologic diagnosis was benign fibrous histiocytoma. Read More

    Collision and composite tumors; radiologic and pathologic correlation.
    Abdom Radiol (NY) 2017 Jun 16. Epub 2017 Jun 16.
    Department of Radiological Sciences, Irvine School of Medicine, University of California, 101 The City Drive South, Suite #1105, Orange, CA, 92868, USA.
    The terms composite and collision tumors have been used interchangeably throughout radiological literature. Both composite and collision tumors involve two morphologically and immunohistochemically distinct neoplasms coexisting within a single organ. However, collision tumors lack the histological cellular intermingling seen in composite tumors. Read More

    Endocr Pract 2017 Jun;23(6):705-715
    A concerted effort has been made in the past decade to better differentiate benign from malignant adrenocortical tumors. Of those tumors found to be adrenocortical carcinomas (ACCs) and through the use of multiple modalities including biochemical, radiologic, and genomic analysis, significant strides have been made in understanding what drives ACC development, how various treatments may result in different outcomes, which ACCs are more likely to respond to various treatments, and overall prognosis. While most patients will have recurrence of their ACC and succumb to their disease, the disease course is highly variable; it is therefore imperative that each patient is treated with individualized attention paid to their particular ACC. Read More

    Disparities in access to care and outcomes in patients with adrenocortical carcinoma.
    J Surg Res 2017 Jun 3;213:138-146. Epub 2017 Mar 3.
    Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address:
    Background: Surgical resection remains the mainstay of treatment for patients with adrenocortical carcinoma (ACC). The aim of the present study is to examine disparities in access to surgical resection and identify factors associated with overall survival following surgical resection.

    Methods: The National Cancer Database was queried for patients with ACC (2004-2013). Read More

    Pattern and Distribution of Distant Metastases in Anaplastic Prostate Carcinoma: A Single-Institute Experience With 101 Patients.
    AJR Am J Roentgenol 2017 Jun 7:1-6. Epub 2017 Jun 7.
    1 Division of Diagnostic Imaging, Body Imaging Section, Unit 1473, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030-4009.
    Objective: The aim of this study was to evaluate the sites and frequencies of distant metastases in patients with anaplastic prostate carcinoma and to correlate those findings with prostate-specific antigen (PSA) levels.

    Materials And Methods: Patients with anaplastic prostate carcinoma (n = 101) underwent CT and bone scans before platinum-based chemotherapy. CT findings were retrospectively reviewed to identify the sites of metastases. Read More

    Severe Cushing's syndrome due to small cell prostate carcinoma - a case and review of literature.
    Endocr Connect 2017 Jun 5. Epub 2017 Jun 5.
    J Conaglen, Waikato Clinical Campus, University of Auckland, Auckland, New Zealand
    Cushings syndrome (CS) due to ectopic adrenocorticotrophic hormone (ACTH) is associated with a variety of tumours most of which arise in the thorax or abdomen. Prostate carcinoma is a rare but important cause of rapidly progressive CS. To report a case of severe CS due to ACTH production from prostate neuroendocrine carcinoma and summarise previous published cases. Read More

    Triple synchronous primary malignancies: a rare occurrence.
    BMJ Case Rep 2017 Jun 5;2017. Epub 2017 Jun 5.
    Department of Oncology, Edwards Comprehensive Cancer Center, Huntington, West Virginia, USA.
    Triple synchronous primary malignant neoplasms are rare. The exact aetiology is unknown; however, risk factors include older age, family history, genetic aberrations, prolonged exposure to carcinogens and smoking. We describe a previously healthy 48-year-old woman who presented with abdominal pain and a palpable abdominal mass. Read More

    Comparison of neurons derived from mouse P19, rat PC12 and human SH-SY5Y cells in the assessment of chemical- and toxin-induced neurotoxicity.
    BMC Pharmacol Toxicol 2017 Jun 5;18(1):42. Epub 2017 Jun 5.
    Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.
    Background: Exposure to chemicals might be toxic to the developing brain. There is a need for simple and robust in vitro cellular models for evaluation of chemical-induced neurotoxicity as a complement to traditional studies on animals. In this study, neuronally differentiated mouse embryonal carcinoma P19 cells (P19 neurons) were compared with human neuroblastoma SH-SY5Y cells and rat adrenal pheochromocytoma PC12 cells for their ability to detect toxicity of methylmercury (MeHg), okadaic acid and acrylamide. Read More

    Surfactant Protein A and Napsin A in the Immunohistochemical Characterization of Canine Pulmonary Carcinomas: Comparison With Thyroid Transcription Factor-1.
    Vet Pathol 2017 Jan 1:300985817712559. Epub 2017 Jan 1.
    1 Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA.
    Thyroid transcription factor-1 (TTF-1) is a specific and sensitive marker for canine pulmonary tumors but is also expressed in thyroid carcinomas, which commonly metastasize to lung. Napsin A and surfactant protein A (SP-A) are used in the histologic diagnosis of non-small-cell lung cancer in humans but have not been thoroughly evaluated in neoplasms of dogs. The objective of this study was to compare the efficacy of immunohistochemistry for SP-A, napsin A, and TTF-1 in the diagnosis of canine pulmonary carcinomas. Read More

    Complete Responses to Mitotane in Metastatic Adrenocortical Carcinoma-A New Look at an Old Drug.
    Oncologist 2017 May 30. Epub 2017 May 30.
    Department of Medicine, Center for Molecular Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
    Purpose: Based largely on reports that predate modern reporting standards, mitotane has been considered a systemic treatment option for both hormone control and antitumor control of metastatic adrenocortical cancer (ACC), although the therapeutic window is narrow.

    Methods: We searched electronic medical records to identify patients with metastatic ACC treated and prescribed single agent mitotane at Memorial Sloan Kettering Cancer Center from March 15, 1989-September 18, 2015. Reference radiologists reviewed all imaging and determined efficacy according to Response Evaluation Criteria in Solid Tumors 1. Read More

    Analysis of histological and immunohistochemical patterns of benign and malignant adrenocortical tumors by computerized morphometry.
    Pathol Res Pract 2017 Jul 9;213(7):815-823. Epub 2017 Mar 9.
    Department of Internal Medicine, Endocrinology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
    Diagnosis of benign and purely localized malignant adrenocortical lesions is still a complex issue. Moreover, histology-based diagnosis may suffer of a moment of subjectivity due to inter- and intra-individual variations. The aim of the present study was to assess, by computerized morphometry, the morphological features in benign and malignant adrenocortical neoplasms. Read More

    Incidental Detection of Synchronous Medullary Thyroid Carcinoma with Bilateral Adrenal Pheochromocytoma on Iodine-123 Metaiodobenzylguanidine Scintigraphy, Leading to Diagnosis of Multiple Endocrine Neoplasia 2A.
    World J Nucl Med 2017 Apr-Jun;16(2):169-171
    Department of Nuclear Medicine and Molecular Imaging, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.
    We report a case of a 29-year-old female with the family history of medullary thyroid carcinoma (MTC) presenting with hematuria and tachycardia, who was found to have bilateral adrenal masses on abdominal computed tomography and biochemical testing compatible with pheochromocytoma. Iodine-123 (I-123) metaiodobenzylguanidine (MIBG) scintigraphy for preoperative planning prior to planned adrenalectomy revealed incidental synchronous unifocal MTC, along with expected bilateral adrenal pheochromocytomas. Pathology confirmed these findings, and subsequent genetic testing confirmed a rearranged during transfection proto-oncogene mutation on exon 11, confirming the clinical diagnosis of multiple endocrine neoplasia 2A (MEN 2A). Read More

    A exceptional collision tumor of primary adrenal angiosarcoma and non-functioning adrenocortical adenoma.
    Pathol Res Pract 2017 Jun 19;213(6):702-705. Epub 2017 Apr 19.
    Department of Anatomic pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan. Electronic address:
    Primary adrenal angiosarcoma is an extremely rare vascular tumor. We report a case of a 63-year-old man with a collision tumor of epithelioid angiosarcoma and adrenocortical adenoma of the right adrenal gland. The adrenal tumor was incidentally observed by a preoperative computed tomography (CT) scan of penis squamous cell carcinoma. Read More

    Minimally invasive resection of adrenal masses in infants and children: results of a European multi-center survey.
    Surg Endosc 2017 May 26. Epub 2017 May 26.
    Pediatric Surgery Unit, Women's and Children's Health Department, University of Padova, Padova, Italy.
    Background: Minimal access adrenal surgery (MAAS) for adrenal pathologies is the standard for many pediatric surgical centers. However, the literature offers few reports and minimal evidence from small case series. The aim of this study was to evaluate the outcomes of pediatric MAAS through a multi-center data analysis. Read More

    A Rare Presentation of Infantile Virilization Secondary to Malignant Etiology.
    Indian J Surg Oncol 2017 Jun 18;8(2):203-205. Epub 2016 Nov 18.
    GMR Varalakshmi Care Hospital, Dist. Srikakulam, Rajam, Andhra Pradesh India.
    Adrenocortical tumor is a rare malignancy (1-2/million) in children with a heterogenous presentation and generally poor prognosis. We report two cases of adrenocortical carcinoma who presented primarily with virilization along with cushingoid features and hypertension. Both children were managed with surgical resection of tumor, steroid replacement, and antihypertensives. Read More

    Percutaneous CT-guided radiofrequency ablation for patients with extrahepatic oligometastases of hepatocellular carcinoma: long-term results.
    Int J Hyperthermia 2017 May 2:1-9. Epub 2017 May 2.
    a State Key Laboratory of Oncology in South China , Collaborative Innovation Center for Cancer Medicine , Guangzhou , PR China.
    Background: The aim of this study was to evaluate the therapeutic outcome of percutaneous computed tomography (CT)-guided radiofrequency ablation (RFA) for extrahepatic oligometastases of hepatocellular carcinoma (HCC).

    Methods: Institutional review board approval was obtained for this retrospective study, and all patients provided written informed consent. Between April 2004 and December 2015, 116 oligometastases (diameter, 5-50 mm; 20. Read More

    Increased F-FDG Uptake in Bilateral Gynecomastia Secondary to Feminizing Adrenal Tumor: A Rare Case Report and Review of Literature.
    Indian J Nucl Med 2017 Apr-Jun;32(2):145-147
    Radiation Medicine Centre, Bhabha Atomic Research Centre, TMC Annexe, Jerbai Wadia Road, Parel, Mumbai, India.
    A 21 year old male who presented with painful enlargement of both the breasts and a hyperestrogenic state, was found to harbor a heterogeneous mass arising from the right adrenal on contrast enhanced Computed Tomography abdomen. The mass was hypermetabolic with no regional, nodal or distant metastases on Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography /Computed Tomography examination. Notably, substantial tracer uptake was seen in bilateral gynecomastia. Read More

    U.S. Food and Drug Administration Approval Summary: Pembrolizumab for the Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma with Disease Progression on or After Platinum-Containing Chemotherapy.
    Oncologist 2017 May 22. Epub 2017 May 22.
    Office of Hematology and Oncology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
    On August 5, 2016, the U.S. Food and Drug Administration granted accelerated approval to pembrolizumab (KEYTRUDA injection, Merck Sharp & Dohme Corp. Read More

    18F-FDG PET/CT of Malignant Angiomyolipoma With Tumor Thrombus.
    Clin Nucl Med 2017 May 19. Epub 2017 May 19.
    From the Department of Radiology, Duke University Medical Center, Durham, NC.
    Renal angiomyolipomas are the most common renal mesenchymal tumors. While classic angiomyolipomas are benign, there are a number of other subtypes. Epithelioid variants are potentially malignant and may be indistinguishable from renal cell carcinoma on imaging. Read More

    Extension of Adrenocortical Carcinoma into the Right Atrium.
    Pak J Med Sci 2017 Mar-Apr;33(2):510-512
    Alfonso Waller, MD. Division of Cardiology, Rutgers - New Jersey Medical School, Newark, NJ 07013, USA.
    Adrenocortical carcinoma (ACC) is a rare and highly aggressive malignant neoplasm which can produce intravascular extension into the inferior vena cava (IVC) rarely extend into the right atrium (RA). We report a case of a male patient with large ACC with extension into the IVC and RA. Computed tomography showed a large right adrenal mass with contiguous tumor thrombus extending into IVC and RA with extension to the level of tricuspid valve. Read More

    Robot-assisted adrenalectomy: indications and drawbacks.
    Updates Surg 2017 May 12. Epub 2017 May 12.
    Department of Digestive, Hepatobiliary, Endocrine, and Oncology Surgery, University of Lorraine, CHU Nancy-Brabois (Adultes), 54511, Vandoeuvre-Les-Nancy, France.
    Adrenal tumors can vary from a benign adrenocortical adenoma with no hormonal secretion to a secretory adrenocortical malignancy (adrenocortical carcinoma) or a hormone-secreting tumor of the adrenal medulla (pheochromocytoma). Currently, laparoscopic adrenalectomy is regarded as the preferred surgical approach for the management of most adrenal surgical disorders, although there are no prospective randomized trials comparing this technique with open adrenalectomy. However, widespread adoption of robotic technology has positioned robotic adrenalectomy as an option in some medical centers. Read More

    TAK-264 (MLN0264) in Previously Treated Asian Patients with Advanced Gastrointestinal Carcinoma Expressing Guanylyl Cyclase C: Results from an Open-label, Non-randomized Phase 1 Study.
    Cancer Res Treat 2017 May 10. Epub 2017 May 10.
    Department of Experimental Therapeutics, National Cancer Center Hospital East, Chiba, Japan.
    Purpose: This phase 1 dose-escalation portion of the study evaluated the safety, pharmacokinetics (PK), and antitumor activity of TAK-264 in Asian patients with advanced gastrointestinal (GI) carcinoma or metastatic or recurrent gastric or gastroesophageal junction adenocarcinoma expressing guanylyl cyclase C (GCC).

    Materials And Methods: Adult patients with advanced GI malignancies expressing GCC (H-score ≥ 10) received TAK-264 on day 1 of 3-week cycles as 30-minute intravenous infusions for up to 1 year or until disease progression or unacceptable toxicity. The primary objectives were to evaluate the safety profile including dose-limiting toxicities (DLTs) during cycle 1, determine the maximum tolerated dose (MTD), and characterize the PK profile of TAK-264 (NCT02391038). Read More

    Clear cell renal cell carcinoma: a comparative study of histological and chromosomal characteristics between primary tumors and their corresponding metastases.
    Virchows Arch 2017 May 10. Epub 2017 May 10.
    IRSET INSERM UMR 1085, Faculté de Médecine de Rennes 1, 35043, Rennes, France.
    Clear cell renal cell carcinoma (ccRCC) has a poor prognosis with a 50% risk of metastases. Little is known about the phenotypic and molecular profiles of metastases regarding their corresponding primary tumors. This study aimed to screen phenotypic and genotypic differences between metastases and their corresponding primary tumors. Read More

    Adrenal metastasis of hepatocellular carcinoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration of the right adrenal gland.
    Rev Esp Enferm Dig 2017 May;109(5):378
    Endoscopia/Aparato Digestivo, Hospital Universitari de Bellvitge, España.
    Recent studies have shown that the adrenal gland is the fourth most common site of HCC extrahepatic metastasis; despite this, the incidence of right adrenal metastasis of HCC is unclear. EUS-guided FNA of the right adrenal gland is technically possible and safe, and should be considered in cases of right adrenal tumors with no diagnostic criteria by imaging test. Read More

    A case of long-term survival after surgical resection for solitary adrenal recurrence of esophageal squamous carcinoma.
    Surg Case Rep 2017 Dec 5;3(1):61. Epub 2017 May 5.
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
    Background: Esophageal carcinomas are highly malignant tumors with a high frequency of lymph node and distant organ metastasis. Treatment for recurrent tumors is generally decided on an individual basis. Although multidisciplinary treatments involving chemotherapy, surgical resection, and radiation are performed, the prognosis remains poor. Read More

    Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.
    Endocr Pathol 2017 May 6. Epub 2017 May 6.
    Cancer Molecular Pathology, School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Q4222, Australia.
    The fourth edition of the World Health Organization (WHO) classification of endocrine tumours contains substantial new findings for the adrenal tumours. The tumours are presented in two chapters labelled as "Tumours of the adrenal cortex" and "Tumours of the adrenal medulla and extra-adrenal paraganglia." Tumours of the adrenal cortex are classified as cortical carcinoma, cortical adenoma, sex cord stromal tumours, adenomatoid tumour, mesenchymal and stromal tumours (myelolipoma and schwannoma), haematological tumours, and secondary tumours. Read More

    Genetics of Adrenocortical Development and Tumors.
    Endocrinol Metab Clin North Am 2017 Jun 22;46(2):419-433. Epub 2017 Feb 22.
    Pediatric Endocrinology Fellowship, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 9D42, 10 Center Drive, MSC 1830, Bethesda, MD 20892-1830, USA. Electronic address:
    This article links the understanding of developmental physiology of the adrenal cortex to adrenocortical tumor formation. Many molecular mechanisms that lead to formation of adrenocortical tumors have been discovered via next-generation sequencing approaches. The most frequently mutated genes in adrenocortical tumors are also factors in normal adrenal development and homeostasis, including those that alter the p53 and Wnt/β-catenin pathways. Read More

    Consolidative Radiotherapy in Metastatic Urothelial Cancer.
    Clin Genitourin Cancer 2017 Apr 12. Epub 2017 Apr 12.
    Division of Oncology, Stanford Hospital, Stanford, CA.
    Background: We report outcomes of a retrospective, single-institution experience with consolidative radiation after chemotherapy in metastatic urothelial cancer (MUC).

    Patients And Methods: From our single-institution database of 2597 patients with urothelial carcinoma treated since 1997, we identified 22 patients with MUC who underwent consolidative radiotherapy after a partial response to chemotherapy with the intent of rendering them disease-free. All patients had undergone primary surgical therapy with either cystectomy or nephroureterectomy. Read More

    A Case Report of Metastatic Breast Cancer Treated with Korean Medicine Therapy as a Substitute for Chemotherapy.
    Case Rep Oncol 2017 Jan-Apr;10(1):27-36. Epub 2017 Jan 16.
    Soram Korean Medicine Hospital, Seoul, Republic of Korea.
    The purpose of this case report is to show the potential benefit of Korean medicine therapy for treating multiple metastatic breast cancer. A 45-year-old Korean woman was diagnosed with right breast invasive ductal carcinoma in August 2012 but did not receive any treatment until October 2015 when she was diagnosed with stage 4 right breast cancer with multiple liver, bone, mesentery, retroperitoneum, and axillary lymph node metastases. After chemo-port insertion, she was treated with palliative chemotherapy and the first line of trastuzumab and paclitaxel, and the port was removed due to port infection. Read More

    Adrenocortical carcinoma co-occurrence with a hepatocellular carcinoma within an adrenohepatic fusion: a case report.
    J Surg Case Rep 2017 Mar 29;2017(3):rjw210. Epub 2017 Mar 29.
    Department of Pathology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
    Adrenohepatic fusion is a relatively common condition that has been reported in the literature and explained as a result of normal aging. However, the presence of a neoplastic process in the adrenohepatic fusion is relatively uncommon. A 48-year-old male presented with RUQ abdominal pain with findings of a huge liver mass with adrenohepatic fusion in the computed tomography scan. Read More

    Surgical approaches in hereditary endocrine tumors.
    Updates Surg 2017 Apr 28. Epub 2017 Apr 28.
    Minimally Invasive Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Via Giustiniani 2, 35128, Padua, Italy.
    Endocrine tumors of thyroid, adrenal and parathyroid glands may be due to germline and inheritable mutations in 5-30% of patients. Medullary Thyroid Carcinoma, Pheochromocytoma, Paraganglioma, and Familial Primary Hyperparathyroidism are the most frequent entity. Hereditary endocrine tumors usually have a suggestive familial history; they occur earlier than sporadic variants, are multifocal, and have increased recurrence rates. Read More

    Effect of mitotane on mouse ovarian follicle development and fertility.
    J Endocrinol 2017 Jul 27;234(1):29-39. Epub 2017 Apr 27.
    EndocrinologyDepartment of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
    Mitotane (MTT) is an adrenolytic drug used in advanced and adjuvant treatment of adrenocortical carcinoma, in Cushing's disease and in ectopic syndrome. However, knowledge about its effects on the ovary is still scarce. The purpose of this study is to investigate the effect of MTT on the ovary using in vivo and in vitro models. Read More

    Establishment of a mouse xenograft model of metastatic adrenocortical carcinoma.
    Oncotarget 2017 Apr 7. Epub 2017 Apr 7.
    Université Côte d'Azur, Valbonne - Sophia Antipolis, France.
    Adrenocortical carcinoma is a rare neoplasm with a poor prognosis. Very important advances have been made in the identification of the genetic determinants of adrenocortical carcinoma pathogenesis but our understanding is still limited about the mechanisms that determine cancer spread and metastasis. One major problem hindering preclinical experimentation for new therapies for adrenocortical carcinoma is represented by the lack of suitable animal models for metastatic disease. Read More

    The efficacy of radiation therapy in adrenocortical carcinoma: A propensity score analysis of a population-based study.
    Medicine (Baltimore) 2017 Apr;96(17):e6741
    Department of Urology, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, P.R. China.
    Adrenocortical carcinoma (ACC) is a rare and malignant tumor. The main treatment is primary surgical resection with or without mitotane therapy. The role of radiation therapy is still controversial. Read More

    "Direct MPR": A Useful Tool for Oblique CT Fluoroscopy-Assisted Puncture.
    Cardiovasc Intervent Radiol 2017 Apr 24. Epub 2017 Apr 24.
    Division of Diagnostic Radiology, Shizuoka Cancer Center, Shizuoka, Japan.
    Objective: Conventional multiplanar reconstruction (MPR) imaging can be used as a tool for planning oblique puncture procedures, but it takes a few minutes to reconstruct and is not appropriate for real-time CT fluoroscopy-assisted puncture. Recently, new MPR technology has been used that requires only 8 s and makes it possible to obtain a nearly real-time CT fluoroscopy-assisted oblique puncture. We refer to it as "direct MPR. Read More

    Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial.
    Lancet 2017 Apr 20. Epub 2017 Apr 20.
    Biomedical Research Network in Oncology (CIBERONC), Pamplona, Spain; Center for Applied Medical Research (CIMA), Pamplona, Spain.
    Background: For patients with advanced hepatocellular carcinoma, sorafenib is the only approved drug worldwide, and outcomes remain poor. We aimed to assess the safety and efficacy of nivolumab, a programmed cell death protein-1 (PD-1) immune checkpoint inhibitor, in patients with advanced hepatocellular carcinoma with or without chronic viral hepatitis.

    Methods: We did a phase 1/2, open-label, non-comparative, dose escalation and expansion trial (CheckMate 040) of nivolumab in adults (≥18 years) with histologically confirmed advanced hepatocellular carcinoma with or without hepatitis C or B (HCV or HBV) infection. Read More

    Therapeutic drug monitoring of mitotane: Analytical assay and patient follow-up.
    Biomed Chromatogr 2017 Apr 22. Epub 2017 Apr 22.
    Department of Pharmacology, Centre Hospitalier Universitaire de Reims, Reims, France.
    Adrenocortical carcinoma (ACC) is an aggressive malignancy of the adrenal gland. Mitotane (o,p'-DDD) is the most effective chemotherapy for ACC. According to the literature, mitotane plasma trough concentrations within 14-20 mg L(-1) are correlated with a higher response rate with acceptable toxicity. Read More

    Topoisomerase 2α and thymidylate synthase expression in adrenocortical cancer.
    Endocr Relat Cancer 2017 Jul 21;24(7):299-307. Epub 2017 Apr 21.
    Department of OncologyUniversity of Turin, Pathology Unit, City of Health and Science Hospital, Turin, Italy.
    Topoisomerase II alpha (TOP2A) and thymidylate synthase (TS) are known prognostic parameters in several tumors and also predictors of efficacy of anthracyclines, topoisomerase inhibitors and fluoropirimidines, respectively. Expression of TOP2A and TS mRNA was assessed in 98 patients with adrenocortical carcinoma (ACC) and protein expression was assessed by immunohistochemistry in a subset of 39 tumors. Ninety-two patients were radically resected for stage II-III disease and 38 of them received adjuvant mitotane. Read More

    Incidental posterior mediastinal paraganglioma: The safe approach to management, case report.
    Int J Surg Case Rep 2017 31;35:25-28. Epub 2017 Mar 31.
    Department of Surgery, Division of Thoracic Surgery, Boston University School of Medicine, Boston, MA, USA. Electronic address:
    Introduction: Paragangliomas are neuroendocrine tumors arising from chromaffin cells located in sympathetic paraganglia. Mediastinal paragangliomas are extremely rare and can be classified as functional or non-functional according to their ability for secreting catecholamines. Patients can be asymptomatic and the diagnosis is usually incidental. Read More

    Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma.
    Oncotarget 2017 Apr;8(14):22825-22834
    Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong, P.R. China.
    Adrenocortical carcinoma (ACC) is a rare, but aggressive endocrine malignancy with a generally poor clinical outcome. There is no effective therapy for advanced and metastatic ACC. In our study, we found that an existing drug (rottlerin) exerted its tumour-suppressive function in ACC. Read More

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