274,494 results match your criteria Adrenal Adenoma


Efficacy and predictors of response to inhaled corticosteroid treatment for chronic cough.

Korean J Intern Med 2018 Dec 13. Epub 2018 Dec 13.

Lung Research Institute of Hallym University College of Medicine, Chuncheon, Korea.

Background/aims: Inhaled corticosteroids (ICS) are a treatment of choice for eosinophilic airway diseases, but their efficacy for other causes of chronic cough is controversial.

Methods: We conducted a prospective observational study to determine the ICS efficacy and clinical predictors of response to ICS in patients with upper airway cough syndrome (UACS) or unexplained chronic cough (UCC). Sixty-eight patients with UACS and 33 patients with UCC (duration of cough ≥ 8 weeks) were treated with ICS: 250 µg of fluticasone propionate or 400 µg of budesonide twice a day at physician's discretion. Read More

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December 2018

Salivary Biomarkers of Parenting Stress in Mothers Under Community Criminal Justice Supervision.

Nurs Res 2019 Jan/Feb;68(1):48-56

Jenna K. Rieder, BA, is Research Assistant, The Graduate Center, The City University of New York, NY. Lorie S. Goshin, PhD, RN, is Assistant Professor; and D.R. Gina Sissoko, BA, is Research Assistant, Hunter College, The City University of New York, NY. Olena Kleshchova, MS, is Research Assistant, The Graduate Center, The City University of New York, NY. Mariann R. Weierich, PhD, is Associate Professor, Hunter College, The City University of New York, NY.

Background: Community criminal justice supervised mothers are an underserved population who experience high rates of psychological distress and unique parenting challenges, but little is known about physiological stress system function in this population.

Objective: We tested the salivary biomarkers of the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis function as predictors of subjective maternal stress.

Method: We recruited 23 mothers (age: M = 35. Read More

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December 2018

Primary malignant tumors of the adrenal glands.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e756s. Epub 2018 Dec 10.

Unidade de Suprarrenal, Laboratorio de Hormonios e Genetica Molecular LIM/42, Servico de Endocrinologia e Metabologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Malignancy must be considered in the management of adrenal lesions, including those incidentally identified on imaging studies. Adrenocortical carcinomas (ACCs) are rare tumors with an estimated annual incidence of 0.7-2 cases per year and a worldwide prevalence of 4-12 cases per million/year. Read More

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December 2018

[68Ga]-Dota Peptide Pet/Ct In Neuroendocrine Tumors: Main Clinical Applications.

Curr Radiopharm 2018 Dec 11. Epub 2018 Dec 11.

Department of Nuclear Medicine, S. Andrea Hospital, La Spezia. Italy.

Objective: Neuroendocrine neoplasms (NENs) are generally defined as rare and heterogeneous tumors. The gastrointestinal system is the most frequent site of NENs localization, however they can be found in other anatomical regions, such as pancreas, lungs, ovaries, thyroid, pituitary, and adrenal glands. Neuroendocrine neoplasms have significant clinical manifestations depending on the production of active peptide. Read More

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December 2018

Comparison of Adding Sufentanil and Low-Dose Epinephrine to Bupivacaine in Spinal Anesthesia: A Randomized, Double-Blind, Clinical Trial.

Anesth Pain Med 2018 Oct 15;8(5):e69600. Epub 2018 Oct 15.

Department of Anesthesiology, Imam Reza Hospital, Birjand University of Medical Sciences, Birjand, Iran.

Background: Spinal anesthesia, as an effective approach, is widely performed in various surgeries with possible complications. To reduce the side effects, many adjuvants are used to maintain desirable sensory and motor blockades and increase the quality and prolong the analgesia.

Methods: In the current double-blind, randomized clinical trial, 105 participants aged 18 - 60 years with ASA class I or II who were candidate for lower limb surgery were randomly allocated to patients receiving bupivacaine 15 mg + normal saline 1 mL (B group), bupivacaine 15 mg + epinephrine 10 µg (BE group), and bupivacaine 15 mg + sufentanyl 5 µg (BS group). Read More

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October 2018

Significant Neutrophilic Emperipolesis in Squamous Cell Carcinoma.

Case Rep Oncol Med 2018 13;2018:1301562. Epub 2018 Nov 13.

Department of Ear, Nose, and Throat Disease, Bakırköy Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

A 53-year-old man was admitted for tooth mobility. A mass was identified at the tooth base by CT. Histopathology of the excisional biopsy revealed a moderately differentiated squamous cell carcinoma. Read More

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November 2018

Radiomics improves efficiency for differentiating subclinical pheochromocytoma from lipid-poor adenoma: a predictive, preventive and personalized medical approach in adrenal incidentalomas.

EPMA J 2018 Dec 21;9(4):421-429. Epub 2018 Sep 21.

7Department of Radiology, Keck Medical Center of USC, Los Angeles, CA USA.

Objectives: This study aims to define a radiomic signature for pre-operative differentiation between subclinical pheochromocytoma (sPHEO) and lipid-poor adrenal adenoma (LPA) in adrenal incidentaloma. The goal was to apply a predictive, preventive, and personalized medical approach to the management of adrenal tumors.

Patients And Methods: This retrospective study consisted of 265 consecutive patients (training cohort, 212 (LPA, 145; sPHEO, 67); validation cohort, 53 (LPA, 36; sPHEO, 17)). Read More

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December 2018

Update of Pheochromocytoma Syndromes: Genetics, Biochemical Evaluation, and Imaging.

Front Endocrinol (Lausanne) 2018 27;9:515. Epub 2018 Nov 27.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.

Pheochromocytomas and paragangliomas (PCCs/PGLs) are rare commonly benign neuroendocrine tumors that share pathology features and clinical behavior in many cases. While PCCs are chromaffin-derived tumors that arise within the adrenal medulla, PGLs are neural-crest-derived tumors that originate at the extraadrenal paraganglia. Pheochromocytoma-paraganglioma (PPGL) syndromes are rapidly evolving entities in endocrinology and oncology. Read More

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November 2018

Hormonal regulation of core clock gene expression in skeletal muscle following acute aerobic exercise.

Biochem Biophys Res Commun 2018 Dec 8. Epub 2018 Dec 8.

Department of Nutrition, Food and Exercise Science, Florida State University, 600 W. College Avenue, Tallahassee, FL, 32306, USA; Institute of Sports Sciences and Medicine, Florida State University, 600 W. College Avenue, Tallahassee, FL, 32306, USA. Electronic address:

Exercise increases skeletal muscle health in part by altering the types of genes that are transcribed. Previous work suggested that glucocorticoids signal through the protein Regulated in Development and DNA Damage 1 (REDD1) to regulate gene expression following acute aerobic exercise. The present study shows that expression of the core clock gene, Period1, is among those modulated by the glucocorticoid-REDD1 signaling pathway in skeletal muscle. Read More

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December 2018

A case of primary aldosteronism who experienced cardiopulmonary arrest, was resuscitated and cured.

J Cardiol Cases 2014 Feb 16;9(2):63-66. Epub 2013 Dec 16.

Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, Fukuoka, Japan.

A 45-year-old female went into cardiopulmonary arrest. She was in ventricular fibrillation (VF) and was defibrillated using an automated external defibrillator. After arrival at our hospital, electrocardiography monitoring showed QT prolongation. Read More

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February 2014

Prolonged hyponatremia due to hypopituitarism in a patient with non-ST-elevation myocardial infarction.

J Cardiol Cases 2014 Dec 30;10(6):226-230. Epub 2014 Aug 30.

Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

A 58-year-old man was admitted for non-ST-elevation myocardial infarction. A medicated stent was used for severe coronary artery stenosis. However, consciousness level progressively deteriorated after angioplasty. Read More

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December 2014

Case of Takotsubo cardiomyopathy after tooth extraction - Unusual trigger of a rare syndrome.

J Cardiol Cases 2014 Oct 17;10(4):129-131. Epub 2014 Jul 17.

Division of Cardiology, Schuechtermann Clinic, Bad Rothenfelde, Germany.

We describe a case of Takotsubo cardiomyopathy in a 75-year-old woman after an elective extraction of 10 teeth of the lower jaw using bilateral mandibular anesthesia. The patient complained of shortness of breath and chest pain after 24 h. Coronary angiography showed smooth normal coronary arteries with thrombolysis in myocardial infarction III flow. Read More

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October 2014

Gonadotropin- and Adrenocorticotropic Hormone-Independent Precocious Puberty of Gonadal Origin in a Patient with Adrenal Hypoplasia Congenita Due to DAX1 Gene Mutation - A Case Report and Review of the Literature: Implications for the Pathomechanism.

Horm Res Paediatr 2018 Dec 11:1-10. Epub 2018 Dec 11.

Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University of Ulm, Ulm, Germany.

Background/aims: Mutations in the DAX1 gene cause X-linked adrenal hypoplasia congenita (AHC) classically associated with hypogonadotropic hypogonadism. Unexpectedly, precocious puberty (PP) has been reported in some cases, its mechanism remaining unclear.

Methods: We longitudinally studied a boy with AHC due to DAX1 gene mutation who developed peripheral PP at age 4. Read More

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December 2018
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Concurrent pituitary and adrenocortical lesions on computed tomography imaging in dogs with spontaneous hypercortisolism.

J Vet Intern Med 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Background: Spontaneous hypercortisolism or Cushing's syndrome in dogs is either pituitary or adrenal dependent, but concurrent pituitary and adrenal hypercortisolism also has been reported.

Objective: To determine how often concurrent pituitary and adrenal lesions are present in dogs with spontaneous hypercortisolism.

Animals: Two hundred one client-owned dogs with spontaneous hypercortisolism. Read More

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December 2018

Genetic testing and surveillance guidelines in hereditary pheochromocytoma and paraganglioma.

J Intern Med 2018 Dec 8. Epub 2018 Dec 8.

Clinical Genetics, Karolinska University Hospital, 171 76, Stockholm.

Pheochromocytomas (PCC) and paragangliomas (PGL), collectively abbreviated PPGL are rare tumours originating from the chromaffin cells in the adrenal medulla (PCC) or the sympathetic or parasympathetic extra-adrenal paraganglia (PGL) (1, 2), Figure 1. The enlarged cell volume leads to increased levels of catecholamines (adrenaline, noraderenaline and/or dopamine) and their metabolites which can be measured in plasma or urine for biochemical diagnosis. Hormone-producing PPGL commonly originate from sympathetic paraganglia in the adrenal glands, abdomen or pelvis (3). Read More

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December 2018
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Adrenal myelolipoma in association with congenital adrenal hyperplasia.

Authors:
Hee Jin Kim

Endocrine 2018 Dec 8. Epub 2018 Dec 8.

Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Chungnam, Republic of Korea.

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December 2018

Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.

Nucleic Acids Res 2018 Dec 8. Epub 2018 Dec 8.

RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.

Efficient delivery of therapeutic RNA beyond the liver is the fundamental obstacle preventing its clinical utility. Lipid conjugation increases plasma half-life and enhances tissue accumulation and cellular uptake of small interfering RNAs (siRNAs). However, the mechanism relating lipid hydrophobicity, structure, and siRNA pharmacokinetics is unclear. Read More

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December 2018
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En Route Resuscitation - Utilization of CCATT to Transport and Stabilize Critically Injured and Unstable Casualties.

Mil Med 2018 Dec 7. Epub 2018 Dec 7.

University of Colorado School of Medicine, Aurora, CO.

Introduction: The U.S. Air Force utilizes specialized Critical Care Air Transport Teams (CCATT) for transporting "stabilized" patients. Read More

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December 2018

Pharmacokinetic interaction between mitotane and etoposide in adrenal carcinoma: a pilot study.

Endocr Connect 2018 Dec;7(12):1409-1414

Pharmacokinetics and Pharmacochemistry Unit, Cochin Hospital, Paris Descartes University, AP-HP, Paris, France.

Background The combination of mitotane and platinum-etoposide chemotherapy is a front-line treatment in metastatic adrenocortical carcinoma (ACC), although this regimen shows limited efficacy. Pharmacokinetic drug-drug interaction between mitotane, a strong CYP3A4 inducer, and etoposide, which is a substrate of CYP3A4, may contribute to chemoresistance. The aim of this pilot study was to assess the pharmacokinetic interaction between mitotane and etoposide in ACC patients. Read More

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December 2018

A Novel, Synthetic, Neuroactive Steroid Is Effective at Decreasing Depression-Like Behaviors and Improving Maternal Care in Preclinical Models of Postpartum Depression.

Front Endocrinol (Lausanne) 2018 23;9:703. Epub 2018 Nov 23.

Neuroscience Department, Tufts University School of Medicine, Boston, MA, United States.

Preclinical testing of treatments for postpartum depression (PPD) has been limited due to the lack of available animal models of such a complex disorder. To address this limitation, our laboratory has generated unique preclinical mouse models that exhibit abnormal postpartum behaviors. Mice with a loss or reduction in the expression of the GABA receptor (GABAR) δ subunit ( or , respectively) and mice that lack the K/Cl co-transporter, KCC2, specifically in corticotropin-releasing hormone (CRH) neurons (KCC2/Crh mice) exhibit depression-like behaviors restricted to the postpartum period and deficits in maternal care, which serve as useful tools for testing novel therapeutic compounds. Read More

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November 2018

Intergenerational Transmission of DNA Methylation Signatures Associated with Early Life Stress.

Curr Genomics 2018 Dec;19(8):665-675

1Department of Genetic Medicine and Development, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland; 2Department of Child & Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland; 3Department of Child & Adolescent Psychiatry, New York University School of Medicine, New York, NY, USA.

Early life stress in humans (i.e. maltreatment, violence exposure, loss of a loved one) and in rodents (i. Read More

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December 2018

How Stress Gets Under the Skin: Early Life Adversity and Glucocorticoid Receptor Epigenetic Regulation.

Curr Genomics 2018 Dec;19(8):653-664

Department of Psychology, Northwestern University, Evanston, IL60208, USA.

Early life adversity is associated with both persistent disruptions in the hypothalamic-pituitary-adrenal (HPA) axis and psychiatric symptoms. Glucocorticoid receptors (GRs), which are encoded by the NR3C1 gene, bind to cortisol and other glucocorticoids to create a negative feedback loop within the HPA axis to regulate the body's neuroendocrine response to stress. Excess methylation of a promoter sequence within NR3C1 that attenuates GR expression, however, has been associated with both early life adversity and psychopathology. Read More

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December 2018

Effects of Dexmedetomidine Combined with Sufentanil on Postoperative Delirium in Young Patients After General Anesthesia.

Med Sci Monit 2018 Dec 10;24:8925-8932. Epub 2018 Dec 10.

Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China (mainland).

BACKGROUND This study was designed to evaluate the effects of combined usage of dexmedetomidine (DEX) and sufentanil on young patients with postoperative delirium (POD) after general anesthesia. MATERIAL AND METHODS We randomized 100 young patients with POD into 4 groups: Group D, Group S, Group DS1, and Group DS2, with loading and maintenance doses of DEX and/or sufentanil administered according to the experimental protocol. Hemodynamic variables, standard visual analogue scale (VAS) scores, sedation agitation scale (SAS) scores, stress hormones, and inflammatory biomarkers were assessed at 5 time-points: baseline (T1); 1 h (T2), 2 h (T3), 4 h (T4), and 8 h (T5) after completion of the loading dose. Read More

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December 2018

[Leiomyosarcoma of the adrenal gland - two cases report].

Pol Merkur Lekarski 2018 Nov;45(269):189-191

Maria Skłodowska-Curie Institute - Oncology Center of Warsaw, Poland: Department of Soft Tissue/Bone Sarcoma and Melanoma.

Primary adrenal leiomyosarcomas are very rare adrenal mesenchymal tumours, only few dozen has been reported in the English language literature so far. We present two cases of patients with primary adrenal leiomyoosarcomas. 80 year-old female admitted with left adrenal tumour with presumptive diagnosis of nonadenoma, laparoscopic adrenalectomy was performed and 85 year-old man who underwent surgical resection by laparotomy of adrenal tumour suspected for adrenal carcinoma. Read More

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November 2018

[Syndrome of inappropriate secretion of antidiuretic hormone in multiple myeloma patients treated with bortezomib, lenalidomide, and dexamethasone combination therapy].

Rinsho Ketsueki 2018 ;59(11):2423-2427

Division of Hematology, Department of Medicine, Showa University School of Medicine.

Hyponatremia occurs while receiving bortezomib-containing combination therapy in multiple myeloma (MM) ; however, the mechanism of hyponatremia remains unclear. A 65-year-old female with MM was treated with bortezomib, lenalidomide, and dexamethasone. Fourteen days after chemotherapy initiation, she developed hyponatremia (serum sodium, 127 mEq/l, compared with 136 mEq/l before chemotherapy) with plasma hypo-osmolality and urine hyper-osmolality. Read More

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January 2018

Long-acting intramuscular ACTH stimulation test for the diagnosis of secondary adrenal insufficiency in children.

J Pediatr Endocrinol Metab 2018 Dec 7. Epub 2018 Dec 7.

Division of Pediatric Endocrinology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Background The diagnosis of adrenal insufficiency (AI) is based on the basal and stimulated levels of serum cortisol in response to the short Synacthen test (SST). In patients with secondary AI (SAI) due to hypothalamic-pituitary-adrenal (HPA) axis defects, the SST has been validated against the insulin tolerance test (ITT), which is the gold standard. However, injection Synacthen is not easily available in some countries, and endocrinologists often use Acton-Prolongatum (intramuscular [IM] long-acting adrenocorticotropic hormone [ACTH]) in place of Synacthen. Read More

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December 2018

Assay of steroids by liquid chromatography-tandem mass spectrometry in monitoring 21-hydroxylase deficiency.

Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.

P Thorsby, Hormone Laboratory, Oslo University Hospital, Departement of Medical Biochemistry, Oslo, Norway.

Immunoassays of steroid hormones are still used in the diagnosis and monitoring of patients with congenital adrenal hyperplasia. However, cross-reactivity between steroids can give rise to falsely elevated steroid levels. Here we compare the use of immunoassays and liquid chromatography-tandem mass spectrometry (LC-MS/MS) in the monitoring of patients with classic 21-hydroxylase deficiency (21OHD). Read More

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December 2018

Transgenerational hypocortisolism and behavioral disruption are induced by the antidepressant fluoxetine in male zebrafish .

Proc Natl Acad Sci U S A 2018 Dec 10. Epub 2018 Dec 10.

Department of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada;

The global prevalence of depression is high during childbearing. Due to the associated risks to the mother and baby, the selective serotonin reuptake inhibitor fluoxetine (FLX) is often the first line of treatment. Given that FLX readily crosses the placenta, a fetus may be susceptible to the disruptive effects of FLX during this highly plastic stage of development. Read More

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December 2018

Metabolic syndrome is a sequela of radiation exposure in hypothalamic obesity among survivors of childhood brain tumors.

J Investig Med 2018 Dec 9. Epub 2018 Dec 9.

University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Survivors of childhood brain tumors may be at risk for early onset of metabolic syndrome, possibly secondary to surgery and/or radiation exposure. This study examines effects of radiation exposure to hypothalamus-pituitary-adrenal axis (HPA) on metabolic risk among survivors of childhood brain tumors. One hundred forty-two met inclusion criteria; 60 had tumor surgery plus radiation exposure (1 Gray (Gy)) to HPA. Read More

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December 2018

Incidence of Anaphylaxis Recorded During 1 Year by the Municipal Emergency Service of Madrid (SAMUR-PC).

J Investig Allergol Clin Immunol 2018 Dec;28(6):438-440

Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.

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December 2018

Relationships between cerebrospinal fluid GABAergic neurosteroid levels and symptom severity in men with PTSD.

Psychoneuroendocrinology 2018 Nov 22;102:95-104. Epub 2018 Nov 22.

The Psychiatric Institute, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, United States.

Allopregnanolone and pregnanolone (together termed allo + pregnan) are neurosteroid metabolites of progesterone that equipotently facilitate the action of gamma-amino-butyric acid (GABA) at GABA receptors. The adrenal steroid dehydroepiandrosterone (DHEA) allosterically antagonizes GABA receptors and facilitates N-methyl-D-aspartate (NMDA) receptor function. In prior research, premenopausal women with posttraumatic stress disorder (PTSD) displayed low cerebrospinal fluid (CSF) levels of allo + pregnan [undifferentiated by the gas chromatography-mass spectrometry (GC-MS) method used] that correlated strongly and negatively with PTSD reexperiencing and negative mood symptoms. Read More

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November 2018

Resting amygdala connectivity and basal sympathetic tone as markers of chronic hypervigilance.

Psychoneuroendocrinology 2018 Nov 26;102:68-78. Epub 2018 Nov 26.

Hunter College, The City University of New York, 695 Park Avenue, New York, NY 10065, USA; The Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, USA. Electronic address:

Background: Chronic hypervigilance, a state of sustained alertness and hyperarousal in the absence of threat, has been shown to predict poorer clinical outcomes post-trauma. An exaggerated and persistent amygdala alerting response to affective information has been proposed as a reactivity-based, and thus indirect, marker of hypervigilance. However, because chronic hypervigilance is a persistent rather than reactive state, it should be directly observable under resting-state conditions without the need for exposure to affectively charged stimuli. Read More

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November 2018

When is epinephrine prescribed for anaphylaxis?

Ann Allergy Asthma Immunol 2018 Dec 6. Epub 2018 Dec 6.

- Allergy Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain; - Gregorio Marañón Health Research Institute, Madrid, Spain; - Biomedical Research Network on Rare Diseases (CIBERER)-U761, Madrid, Spain.

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December 2018

Challenges and Opportunities in Adolescent Gynecology Patients with Surgically-Treated Congenital and Acquired Anomalies: Transition of Care from Pediatric to Adult Surgery.

J Pediatr Adolesc Gynecol 2018 Dec 5. Epub 2018 Dec 5.

Department of obstetrics and gynecology, university of Louisville, USA.

The transition from adolescence to young adulthood in patients with reproductive health care needs such as disorders of sexual development (DSDs) and congenital anomalies is a complex process occurring over several years. The transition process for these patients has is still poorly understood. The patients with DSDs and reproductive issues have specific and unique issues regarding timing of disclosure of diagnosis, genital examinations, gonadectomy, vaginal treatments, surgical procedures hormone replacement therapy, use of long term medication and potential cancer screening. Read More

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December 2018

A steady state system for in vitro evaluation of steroidogenic pathway dynamics: Application for CYP11B1, CYP11B2 and CYP17 inhibitors.

J Steroid Biochem Mol Biol 2018 Dec 6. Epub 2018 Dec 6.

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Department of Internal Medicine III, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Electronic address:

Disorders featuring dysregulated adrenal steroidogenesis, such as primary aldosteronism, can benefit from targeted therapies. The aldosterone and cortisol producing enzymes, aldosterone synthase (CYP11B2) and 11-beta-hydroxylase (CYP11B1), share 93% homology requiring selective drugs for pharmacological treatment. Herein, we introduce an effective in vitro assay for evaluation of steroidogenic enzyme kinetics based on intracellular flux calculations. Read More

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December 2018

Glucocorticoid-activation system mediated glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming alteration of adrenal dysfunction induced by prenatal caffeine exposure.

Toxicol Lett 2018 Dec 6. Epub 2018 Dec 6.

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disorder, Wuhan 430071, China. Electronic address:

Glucocorticoids play a major factor in fetal maturation and fate decision after birth. We have previously demonstrated that prenatal caffeine exposure (PCE) resulted in adrenal dysplasia. However, its molecular mechanism has not been clarified. Read More

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December 2018

Meeting the challenges of reconstructive urology - Where are we now?

J Pediatr Surg 2018 Nov 7. Epub 2018 Nov 7.

Department of Paediatric Urology, Great Ormond Street Hospital for Children, Great Ormond Street, London, UK. Electronic address:

This is based on the 2018 Storz Urology Lecture at the BAPS Conference and is a personal review of three reconstructive paediatric urological conditions: hypospadias, congenital adrenal hyperplasia, and bladder exstrophy from the perspective of changing expectations and outcomes. LEVEL OF EVIDENCE: V (Expert Opinion). Read More

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November 2018

Efficacy of Articaine Versus Lidocaine Administered as Supplementary Intraligamentary Injection after a Failed Inferior Alveolar Nerve Block: A Randomized Double-blind Study.

J Endod 2018 Dec 5. Epub 2018 Dec 5.

Department of Conservative Dentistry and Endodontics, Faculty of Dentistry, Jamia Millia Islamia, Jamia Nagar, New Delhi, India.

Introduction: The present study comparatively evaluated the anesthetic efficacy of 4% articaine versus 2% lidocaine given as supplemental intraligamentary injections after a failed inferior alveolar nerve block.

Methods: One hundred six adult patients with symptomatic irreversible pulpitis in a mandibular first or second molar received an initial inferior alveolar nerve block with 2% lidocaine with 1:80,000 epinephrine. Pain during the endodontic treatment was assessed using the Heft-Parker visual analog scale. Read More

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December 2018

New insights into the impact of primary lung adenocarcinoma location on metastatic sites and sequence: A multicenter cohort study.

Lung Cancer 2018 Dec 5;126:139-148. Epub 2018 Nov 5.

National Korányi Institute of Pulmonology, Budapest, Hungary. Electronic address:

Introduction: The presence of organ metastases is a major factor for unfavorable prognosis in lung adenocarcinoma (LADC). However, the influence of primary tumor location on metastatic sites and sequence has not been extensively analyzed.

Methods: We performed a multicenter cohort study, evaluating clinicopathological data of 1126 Caucasian LADC patients, focusing on the distinct location of primary tumors and metastatic sites during disease progression. Read More

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December 2018

CHIPS-Child: Testing the developmental programming hypothesis in the offspring of the CHIPS trial.

Pregnancy Hypertens 2018 Oct 19;14:15-22. Epub 2018 May 19.

Obstetrics and Gynaecology, Universite de Sherbrooke, Canada. Electronic address:

Objectives: As a follow-up to the CHIPS trial (Control of Hypertension In Pregnancy Study) of 'less tight' (versus 'tight') control of maternal blood pressure in pregnancy, CHIPS-Child investigated potential developmental programming of maternal blood pressure control in pregnancy, by examining measures of postnatal growth rate and hypothalamic-pituitary adrenal (HPA) axis activation.

Methods: CHIPS follow-up was extended to 12 ± 2 months corrected post-gestational age for anthropometry (weight, length, head/waist circumference). For eligible children with consent for a study visit, we collected biological samples (hair/buccal samples) to evaluate HPA axis function (hair cortisol levels) and epigenetic change (DNA methylation analysis of buccal cells). Read More

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October 2018

Effects of arsenic and lead combined exposure on brain monoaminergic system and behavioral functions in rats: Reversal effect of MiADMSA.

Toxicol Ind Health 2018 Dec 10:748233718814990. Epub 2018 Dec 10.

2 Department of Zoology, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.

In this study, we evaluated the therapeutic efficacy of monoisoamyldimercaptosuccinic acid (MiADMSA) against individual and combined effects of arsenic (As) and lead (Pb) on the monoaminergic system and behavioral functions in rats. Pregnant rats were exposed to sodium metaarsenite (50 ppm) and lead acetate (0.2%) individually and in combination (As = 25 ppm + Pb = 0. Read More

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December 2018
1.710 Impact Factor

Emergency call characteristics and EMS dispatcher protocol adherence for possible anaphylaxis.

Prehosp Emerg Care 2018 Dec 11:1-24. Epub 2018 Dec 11.

e Research Institute at Nationwide Childrens Hospital, Center for Injury Research and Policy , 700 Children's Drive, RB III , Columbus , 43205-2664 United States.

Objective: Anaphylaxis is a medical emergency requiring prompt recognition and treatment with intramuscular epinephrine to optimize outcomes. To date, there is a paucity of data regarding the demographic characteristics of the subset of patients calling 911 for allergic reactions and the emergency medical services (EMS) dispatcher's adherence to national protocols for their response to a suspected allergic reaction.

Methods: We conducted a retrospective review of dispatch calls to a local municipality that were dispatched with an impression of an "allergic reaction" or "difficulty breathing related to a suspected allergic reaction" from January 2016 to June 2016. Read More

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December 2018

A Review and Assessment of Drug-Induced Thrombocytosis.

Ann Pharmacother 2018 Dec 10:1060028018819450. Epub 2018 Dec 10.

1 Southwestern Oklahoma State University, Weatherford, OK, USA.

Objectives: The purpose of this article is to review the current literature on drug-induced thrombocytosis with the goal of critically assessing causality and providing a comprehensive review of the topic. Thrombopoietic growth factors, such as thrombopoietin-receptor agonists (romiplostim and eltrombopag) and erythropoietin are not included in our review.

Data Sources: The literature search included published articles limited to the English language and humans in MEDLINE, EMBASE, and Web of Science databases. Read More

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December 2018

[Endocrine complications in primary immunodeficiency diseases].

Authors:
Zita Halász

Orv Hetil 2018 Dec;159(49):2065-2072

I. Gyermekgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Bókay J. u. 53., 1083.

Experimental and clinical data suggest a complex interaction between the endocrine and immune systems. However, only few epidemiological studies are available dealing with endocrine complications in different types of primary immunodeficiency diseases. It is well documented that there is a close association between immunodeficiency syndromes and the development of autoimmune disorders. Read More

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December 2018

Psi Chi/APA Edwin B. Newman Graduate Research Award: Cope Feurer.

Authors:

Am Psychol 2018 Dec;73(9):1256-1258

The Edwin B. Newman Graduate Research Award is given jointly by Psi Chi and APA. The award was established to recognize young researchers at the beginning of their professional lives and to commemorate both the 50th anniversary of Psi Chi and the 100th anniversary of psychology as a science (dating from the founding of Wundt's laboratory). Read More

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December 2018

Hypercortisolism in Newly Diagnosed Type 2 Diabetes: A Prospective Study of 384 Newly Diagnosed Patients.

Horm Metab Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

Cross-sectional studies in small and selected populations report a high prevalence of hypercortisolism in patients with type 2 diabetes (T2D), which could have therapeutic implications, if confirmed. We therefore estimated the prevalence of hypercortisolism in a large and unselected cohort of recently diagnosed T2D patients. Consecutive patients with recently diagnosed T2D first underwent an overnight dexamethasone (1 mg) suppression test (OD). Read More

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December 2018
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Urine Catecholamines in Children with Severe Enterovirus A71 infection: Comparison with Paediatric Septic Shock.

Biomarkers 2018 Dec 6:1-15. Epub 2018 Dec 6.

a Children's Medical Center , Taichung Veterans General Hospital , Taichung , Taiwan.

Purpose: Hypercatecholaminemia-related heart failure has been proposed as the main cause of enterovirus A71-related (EV-A71) early mortality. The purpose of this study was to measure urine catecholamine concentrations in severe EV-A71-infected children.

Methods: A total of 35 children, aged 2. Read More

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December 2018

Validation of the Targeted Metabolomic Pathway in the Hippocampus and Comparative Analysis with the Prefrontal Cortex of Social Defeat Model Mice.

J Neurochem 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.

The proportion of major depressive disorder (MDD) patients around the world has increased remarkably. Although many studies of MDD have been conducted based on classic hypotheses, like alteration of the hypothalamic-pituitary-adrenal axis or monoamine neurotransmitters, the mechanisms underlying MDD remain unclear. Aiming to further investigate the mechanisms of MDD, liquid-chromatography tandem mass spectrometry was employed to measure target metabolites in the hippocampus (HIPPO) of chronic social defeat stress (CSDS) model mice. Read More

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December 2018

Advantages of Intraprocedural Unenhanced CT During Adrenal Venous Sampling to Confirm Accurate Catheterization of the Right Adrenal Vein.

Cardiovasc Intervent Radiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Purpose: To evaluate the advantages of intraprocedural CT during adrenal venous sampling (AVS) to confirm accurate catheterization of the right adrenal vein (RAV).

Materials And Methods: This single-institution study included 106 patients (mean age 52.4 years; range 28-74 years) with primary aldosteronism who performed contrast-enhanced CT (CECT) before AVS following AVS between January 2011 and March 2018. Read More

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December 2018
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