8,244 results match your criteria Adrenal Adenoma


[Paraneoplastic Cushing's syndrome as cause of refractory hypokalemia].

Dtsch Med Wochenschr 2020 Jun 3;145(11):783-786. Epub 2020 Jun 3.

Abteilung für Endokrinologie, Diabetologie und Metabolismus, Medizinische Universitätsklinik, Kantonsspital Aarau, Schweiz.

History:  A 58-year-old man presented with refractory hypokalemia and rapid weight gain. On examination, he had high blood pressure, central obesity and bilateral pitting edema.

Findings And Diagnosis:  Biochemical tests showed hypokalemic metabolic alkalosis due to ACTH-dependent hypercortisolism. Read More

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http://dx.doi.org/10.1055/a-1163-9873DOI Listing

Pregnancy during the course of Cushing's syndrome: a case report and literature review.

Endocrinol Diabetes Metab Case Rep 2020 Apr 12;2020. Epub 2020 Apr 12.

Division of Endocrinology, Guillermo Almenara Irigoyen National Hospital, Lima, Peru.

Summary: Cushing's syndrome is an endocrine disorder that causes anovulatory infertility secondary to hypercortisolism; therefore, pregnancy rarely occurs during its course. We present the case of a 24-year-old, 16-week pregnant female with a 10-month history of unintentional weight gain, dorsal gibbus, nonpruritic comedones, hirsutism and hair loss. Initial biochemical, hormonal and ultrasound investigations revealed hypokalemia, increased nocturnal cortisolemia and a right adrenal mass. Read More

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http://dx.doi.org/10.1530/EDM-20-0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159255PMC

Different pathogenesis of glucose intolerance in two subtypes of primary aldosteronism: aldosterone-producing adenoma and idiopathic hyperaldosteronism.

J Diabetes Investig 2020 May 29. Epub 2020 May 29.

Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.

Aims/introduction: An increased risk of diabetes mellitus has been reported in primary aldosteronism, but the pathogenesis of glucose intolerance between the primary aldosteronism subtypes remains unclear. This study aimed to evaluate glucose metabolism in oral glucose tolerance test between aldosterone-producing adenoma and idiopathic hyperaldosteronism, and characterize patients with improved glucose intolerance following primary aldosteronism treatment.

Materials And Methods: Oral glucose tolerance test was performed in 116 patients who were diagnosed with primary aldosteronism and received adrenal venous sampling for subtyping. Read More

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http://dx.doi.org/10.1111/jdi.13312DOI Listing

Adrenal Adenomas versus Metastases: Diagnostic Performance of Dual-Energy Spectral CT Virtual Noncontrast Imaging and Iodine Maps.

Radiology 2020 May 26:192227. Epub 2020 May 26.

From the Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.

Background Dual-energy CT allows virtual noncontrast (VNC) attenuation and iodine density measurements from contrast material-enhanced examination, potentially enabling adrenal lesion characterization. However, data regarding diagnostic performance remain limited, and combined diagnostic values have never been investigated. Purpose To determine whether VNC attenuation, iodine density, and combination of the two allow reliable differentiation between adrenal adenomas and metastases. Read More

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http://dx.doi.org/10.1148/radiol.2020192227DOI Listing

Stemness regulation of the adrenal mixed corticomedullary tumorigenesis-a case-control study.

Neoplasia 2020 Jul 18;22(7):263-271. Epub 2020 May 18.

Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan. Electronic address:

Mixed corticomedullary tumor is an adrenal tumor intermixed with cortical and medullary cells. It is extremely rare with unclear tumorigenesis. We reported a 32-year-old female, manifested with typical Cushing's syndrome and hypertension, to be diagnosed with right huge adrenal mixed corticomedullary tumor (8. Read More

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http://dx.doi.org/10.1016/j.neo.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240194PMC

Adrenalectomy during pregnancy: A 15-year experience at a tertiary referral center.

Surgery 2020 May 17. Epub 2020 May 17.

Department of Digestive, Hepato-biliary and Endocrine Surgery, Referral Center for Rare Adrenal Diseases, Cochin Hospital, APHP, Paris, France; Faculté de Médecine Paris Descartes, Université Paris Descartes, Sorbonne Paris Cité, France; INSERM Unité 1016, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Institut Cochin, Paris, France.

Background: Adrenal lesions diagnosed during pregnancy remain rare, and their management is challenging because of maternal physiologic modifications, restricted imaging investigations, and contraindications to several treatments. Surgical issues of adrenalectomy during pregnancy and consequences on perinatal outcomes are poorly described. We therefore aimed to report maternal and fetal outcomes after adrenalectomy during pregnancy. Read More

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http://dx.doi.org/10.1016/j.surg.2020.03.019DOI Listing

Pregnancy-induced Cushing's syndrome with an adrenocortical adenoma overexpressing LH/hCG receptors: a case report.

BMC Endocr Disord 2020 May 11;20(1):62. Epub 2020 May 11.

Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China.

Background: Pregnancy-induced Cushing's syndrome (CS) with an adrenocortical adenoma overexpressing luteinizing hormone (LH)/human choriogonadotropin (hCG) receptors (LHCGR) has been rarely reported in the literatures. This peculiar condition challenges the canonical diagnosis and management of CS.

Case Presentation: A 27-year-old woman (G2P0A1) presented at 20 weeks gestational age (GA) with overt Cushingoid clinical features. Read More

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http://dx.doi.org/10.1186/s12902-020-0539-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216527PMC
May 2020
1.673 Impact Factor

ARE THERE RELIABLE PREDICTORS FOR THE IMPAIRED QUALITY OF LIFE IN PATIENTS WITH CUSHING'S SYNDROME?

Acta Endocrinol (Buchar) 2019 Oct-Dec;15(4):482-490

Medical University Sofia, Faculty of Medicine - Department of Endocrinology, Sofia, Bulgaria.

Context: Patients with Cushing's syndrome (CS) of any etiology experience a number of physical and psychological symptoms which impact negatively on health-related quality of life (HRQoL).

Subjects And Methods: HRQoL was measured using CushingQoL questionnaire.

Results: The first part of our study was a cross-sectional analysis of 141 patients with CS over a 10-year period. Read More

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http://dx.doi.org/10.4183/aeb.2019.482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200113PMC

Conned by Conn's: The Manifestation of Conn's Syndrome Post-renal Transplant in a Patient with Polycystic Kidney Disease.

Cureus 2020 Apr 2;12(4):e7512. Epub 2020 Apr 2.

Radiology, Hospital of the University of Pennsylvania, Philadelphia, USA.

We present the case of a 66-year-old African-American male with end-stage renal disease (ESRD) secondary to polycystic kidney disease (PCKD), with well-controlled hypertension. He was placed on peritoneal dialysis for two years before successfully undergoing a cadaveric renal transplant. There was an immediate graft function with no relevant postoperative complications. Read More

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http://dx.doi.org/10.7759/cureus.7512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195196PMC

Evaluation of various confirmatory tests for the diagnosis of aldosterone-producing adenoma.

J Renin Angiotensin Aldosterone Syst 2020 Apr-Jun;21(2):1470320320919610

Division of Nephrology and Hypertension, The Jikei University School of Medicine, Japan.

Introduction: Adrenal venous sampling is useful for discriminating unilateral and bilateral hypersecretion in patients with primary aldosteronism, but it is relatively invasive. To determine the site of hypersecretion more non-invasively, we evaluated predictors of unilateral hypersecretion.

Materials And Methods: We evaluated the baseline characteristics and the results of confirmatory tests of 123 patients with primary aldosteronism who underwent adrenal venous sampling. Read More

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http://dx.doi.org/10.1177/1470320320919610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227155PMC

Immunohistochemical Analysis of the Metabolic Phenotype of Adrenal Cortical Carcinoma.

Endocr Pathol 2020 May 4. Epub 2020 May 4.

Department of Pathology, University Health Network, 200 Elizabeth Street, 11th floor, Toronto, ON, M5G 2C4, Canada.

Metabolic reprogramming is a cellular process contributing to carcinogenesis. However, it remains poorly understood in adrenal cortical carcinoma (ACC), an aggressive malignancy with overall poor prognosis and limited therapeutic options. We characterized the metabolic phenotype of ACC, by examining the immunoprofile of key proteins involved in glucose metabolism, hexokinase (HK1), pyruvate kinase (PKM1, PKM2), succinate dehydrogenase (SDHB), and phospho-S6 ribosomal protein (pS6), in a tissue microarray of 137 adrenal cortical tissue samples. Read More

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http://dx.doi.org/10.1007/s12022-020-09624-3DOI Listing

Utility of the 10 Hounsfield unit threshold for identifying adrenal adenomas: Can we improve?

Am J Surg 2020 Apr 21. Epub 2020 Apr 21.

Division of Surgical Oncology, Department of Surgery, Ohio State University Comprehensive Cancer Center and Ohio State University Wexner Medical Center, USA. Electronic address:

Background: Current recommendations using Hounsfield units (HU) ≤ 10 to identify adrenal adenomas on unenhanced computed tomography (CT) miss 10-40% of benign adenomas. We sought to determine if changing HU threshold and adding absolute percent contrast washout (APW) criteria would identify adrenal adenomas better than current recommendations.

Methods: Imaging characteristics were compared between patients with adenomas (n = 128) and those with non-adenomas (n = 54) after unilateral adrenalectomy. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.04.021DOI Listing

Preresection Radiologic Assessment and Imaging Features of 156 Pathologically Proven Adrenal Adenomas.

J Comput Assist Tomogr 2020 May/Jun;44(3):419-425

From the Departments of Diagnostic Radiology.

Purpose: The aims of the study were to assess the typical and atypical radiologic features of pathologically proven adrenal adenomas and to determine the relationship between the radiologic and histopathologic classification.

Methods: We retrospectively studied 156 pathologically proven adrenal adenomas in 154 patients from our institutional databases who have computed tomography (CT) and/or magnetic resonance imaging (MRI) examinations before intervention. We determined the histopathologic diagnosis (typical or atypical) using Weiss scoring and classified the adenomas radiologically into typical, atypical, or indeterminate based on lesion size, precontrast CT attenuation, absolute percentage washout, calcification, and necrosis. Read More

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http://dx.doi.org/10.1097/RCT.0000000000001018DOI Listing

EXPLORATION OF THE SEATED SALINE SUPPRESSION TEST FOR THE DIAGNOSIS OF PRIMARY ALDOSTERONISM IN CHINESE POPULATION.

Endocr Pract 2020 Apr 27. Epub 2020 Apr 27.

From: Department of Endocrinology and Metabolism, Adrenal Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.

We prospectively investigated the accuracy of the seated saline suppression test (SSST) in 113 patients with hypertension (including 93 PA and 20 essential hypertension (EH)) in the Department of Endocrinology and Metabolism. Each patient underwent an recumbent saline suppression test (RSST) and SSST. The accuracy of the SSST for a confirmative primary aldosteronism (PA) diagnosis and subtype classification was evaluated and compared with the RSST. Read More

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http://dx.doi.org/10.4158/EP-2020-0064DOI Listing
April 2020
2.811 Impact Factor

The value of signal intensity on T1-weighted chemical shift magnetic resonance imaging combined with proton magnetic resonance spectroscopy for the diagnosis of adrenal adenomas.

Radiol Bras 2020 Mar-Apr;53(2):86-94

Escola Paulista de Medicina da Universidade Federal de São Paulo (EPM-Unifesp), São Paulo, SP, Brazil.

Objective: To investigate the advantages of using modified signal intensity measurements on chemical shift imaging alone or in conjunction with proton magnetic resonance spectroscopy in the differential diagnosis of adrenal adenomas.

Materials And Methods: This was a prospective study involving 97 patients with adrenal nodules or masses. The signal intensity index (SII) was calculated as [( ∕ ()] × . Read More

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http://dx.doi.org/10.1590/0100-3984.2019.0095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170587PMC

Developments in Primary Aldosteronism Subtyping Using Steroid Profiling.

Horm Metab Res 2020 Apr 24. Epub 2020 Apr 24.

Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.

Adrenal venous sampling is the standard of care for identifying patients with unilateral primary aldosteronism, which is often caused by an aldosterone producing adenoma and can be cured with surgery. The numerous limitations of adrenal venous sampling, including its high cost, scarce availability, technical challenges, and lack of standardized protocols, have driven efforts to develop alternative, non-invasive tools for the diagnosis of aldosterone producing adenomas. Seminal discoveries regarding the pathogenesis of aldosterone producing adenomas made over the past decade have leveraged hypotheses-driven research of steroid phenotypes characteristic of various aldosterone producing adenomas. Read More

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http://dx.doi.org/10.1055/a-1141-3526DOI Listing

Phenotypic and genotypic features of a large kindred with a germline AIP variant.

Clin Endocrinol (Oxf) 2020 Apr 23. Epub 2020 Apr 23.

Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus C, Denmark.

Context: Acromegaly is usually a sporadic disease, but familial cases occur. Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are associated with familial pituitary adenoma predisposition. However, the pathogenicity of some AIP variants remains unclear and additional unknown genes may be involved. Read More

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http://dx.doi.org/10.1111/cen.14207DOI Listing

[A Case of 18FDG PET/CT-Positive Adrenal Adenoma Suspected of Being Adrenal Metastasis of Synchronous Triple Cancer].

Hinyokika Kiyo 2020 Mar;66(3):77-80

The Department of Urology, Osaka University Graduate School of Medicine.

A 66-year-old man was referred to our hospital because of positive fecal occult blood test. Gastric and rectal cancers were diagnosed by upper and lower endoscopic biopsy, respectively. Enhanced computed tomography (CT) indicated a pulmonary tumor and a left adrenal mass with a diameter of 15 mm presenting heterogenous enhancement. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_66_3_77DOI Listing

Pericardial Effusion as an Initial Presentation of Panhypopituitarism.

Eur J Case Rep Intern Med 2020 24;7(4):001478. Epub 2020 Feb 24.

Department of Internal Medicine, Hospital Garcia de Orta, Almada, Portugal.

Pericardial effusion has a broad spectrum of clinical presentation, ranging from an incidental finding on imaging to a potentially fatal emergency such as pericardial tamponade, the most severe presentation. The authors present a case of a middle-aged male hospitalized due to shortness of breath. Initial work-up was positive for massive pericardial effusion with haemodynamic compromise. Read More

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http://dx.doi.org/10.12890/2020_001478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162561PMC
February 2020

Cardiovascular and metabolic risk factors in patients with subclinical Cushing.

Endocrine 2020 Apr 16. Epub 2020 Apr 16.

Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.

Purpose: Adrenal incidentalomas (AI) are discovered after work-up unrelated to adrenal gland diseases; up to 30% of AI show subclinical endogenous cortisol excess (SH), frequently associated to hypertension, obesity, metabolic disorders and increased incidence of cardiovascular events (CVEs).

Methods: We analysed 628 AI patients divided into two groups: 471 non-functional adrenal adenoma (NFA) and 157 SH. All patients underwent complete examinations, 24-h ambulatory blood pressure monitoring, biohumoral parameters and vascular damage markers, such as c-IMT and ankle brachial index. Read More

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http://dx.doi.org/10.1007/s12020-020-02297-2DOI Listing
April 2020
3.527 Impact Factor

Reliability of adrenal computed tomography in predicting the functionality of adrenal incidentaloma.

Niger Postgrad Med J 2020 Apr-Jun;27(2):101-107

Department of Biochemistry, College of Medicine, University of Basrah, Basrah, Iraq.

Background: Adrenal incidentaloma (AI) is an adrenal mass discovered accidentally during abdominal or chest imaging techniques not aimed to adrenal gland assessment. Guidelines suggested confirming the benignity of AI radiologically and excluding hormonal dysfunctions. This study evaluated the reliability of computed tomography (CT) scan radiological parameters in predicting the functionality of AI. Read More

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http://dx.doi.org/10.4103/npmj.npmj_156_19DOI Listing

[Design and clinical application of goal-oriented retroperitoneoscopic adrenalectomy].

Zhonghua Yi Xue Za Zhi 2020 Apr;100(14):1087-1090

Department of Urology, the First People's Hospital of Lianyungang Affiliated to Xuzhou Medical University, Lianyungang 222061, China.

To investigate the goal-oriented retroperitoneoscopic adrenalectomy and report the initial experiment. A total of 102 patients were selected to our clinic experiment, and performed retroperitoneoscopic adrenalectomy with the new method. including adrenal cortex adenoma 76 cases, phaochromocytoma 12 cases, adrenal cyst 6 cases, myelolipoma 4 cases, gangliocytoma 1 case and corticohyperplassia 3 cases. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20190704-01498DOI Listing

Association between thyroid function and serum cortisol in cortisol-producing adenoma patients.

Endocrine 2020 Apr 14. Epub 2020 Apr 14.

Shanghai Key Laboratory for Endocrine Tumors, Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai National Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, PR China.

Purpose: Thyroid dysfunction has been reported in hypercortisolism. Previous findings regarding changes in thyroid function due to cortisol-producing adenoma (CPA) have been inconsistent. The study aimed to investigate the association between thyroid function and excessive cortisol secretion in patients with CPA and to explore the changes in pituitary function after adrenalectomy. Read More

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http://dx.doi.org/10.1007/s12020-020-02278-5DOI Listing

Immunohistochemistry of the Human Adrenal CYP11B2 in Normal Individuals and in Patients with Primary Aldosteronism.

Horm Metab Res 2020 Apr 14. Epub 2020 Apr 14.

Department of Uro-Oncology, Saitama Medical University International Medical Center, Saitama, Japan.

The CYP11B2 enzyme is the terminal enzyme in the biosynthesis of aldosterone. Immunohistochemistry using antibodies against CYP11B2 defines cells of the adrenal ZG that synthesize aldosterone. CYP11B2 expression is normally stimulated by angiotensin II, but becomes autonomous in primary hyperaldosteronism, in most cases driven by recently discovered somatic mutations of ion channels or pumps. Read More

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http://dx.doi.org/10.1055/a-1139-2079DOI Listing

Clinical course of adrenal myelolipoma: A long-term longitudinal follow-up study.

Clin Endocrinol (Oxf) 2020 Apr 10. Epub 2020 Apr 10.

Division of Endocrinology, Diabetes, and Nutrition, Mayo Clinic, Rochester, MN, USA.

Objective: We aimed to describe clinical course of myelolipoma and to identify predictors of tumour growth and need for surgery.

Design: A retrospective study.

Patients: Consecutive patients with myelolipoma. Read More

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http://dx.doi.org/10.1111/cen.14188DOI Listing

Metastatic Small-Cell Lung Cancer Presenting as Primary Adrenal Insufficiency.

Case Rep Oncol Med 2020 11;2020:7018619. Epub 2020 Mar 11.

Department of Internal Medicine, Grand Strand Medical Center, Myrtle Beach, SC, USA.

A 40-year-old male smoker with HIV was admitted for cough, hypotension, and abdominal pain for 5 days. Chest radiography showed a right lower lobe consolidation. CT of the chest, abdomen, and pelvis revealed paratracheal adenopathy, a 5. Read More

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http://dx.doi.org/10.1155/2020/7018619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106905PMC

A rare presentation of adrenal adenoma in infancy: isolated Cushing`s syndrome.

Turk J Pediatr 2020 ;62(1):146-151

Department of Pediatric Surgery, Koç University School of Medicine, İstanbul, Turkey.

Adrenocortical tumors are rare in children. Most of these tumors present with endocrinological manifestations, majority of which with virilizing features alone or in combination with over production of other adrenal hormones. However, it is uncommon of an adrenocortical tumor to present solely with Cushing`s syndrome. Read More

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http://dx.doi.org/10.24953/turkjped.2020.01.022DOI Listing
January 2020

Age, Gender, and Body Mass Index as Determinants of Surgical Outcome in Primary Aldosteronism.

Horm Metab Res 2020 Apr 6. Epub 2020 Apr 6.

Department of Diabetes, Endocrinology and Metabolism, National Center for Global Health and Medicine, Tokyo, Japan.

Although unilateral primary aldosteronism (PA) should be curable by adrenalectomy (ADX), postsurgical outcome is affected by several clinical factors. Herein we reviewe the importance of age, gender, and BMI as determinants of surgical success based on the recent findings including a nation-wide, multicenter study in Japan (JPAS/JRAS). It is important to determine whether ADX for elderly patients with unilateral PA is as beneficial as younger patients. Read More

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http://dx.doi.org/10.1055/a-1139-1783DOI Listing

Cardiac Myxoma Caused by Fumarate Hydratase Gene Deletion in Patient With Cortisol-Secreting Adrenocortical Adenoma.

J Clin Endocrinol Metab 2020 Jun;105(6)

Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Context: Germline mutations in fumarate hydratase (FH) gene are known to cause hereditary leiomyomatosis and renal cell carcinoma (HLRCC) and are occasionally accompanied with cutaneous and uterine leiomyoma or cortisol-producing adrenocortical hyperplasia. However, the association between FH mutations and cardiac or adrenocortical tumors has remained unknown. Here, we identified a novel deletion in FH, exhibiting cardiac myxoma and subclinical Cushing syndrome due to adrenocortical tumor. Read More

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http://dx.doi.org/10.1210/clinem/dgaa163DOI Listing

Reticulin staining pattern in the differential diagnosis of benign parathyroid lesions.

J Endocrinol Invest 2020 Apr 2. Epub 2020 Apr 2.

Department of General Surgery, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.

Aim: A reticulin staining pattern (RSP) can be used for the differential diagnosis of endocrine gland lesions, as in the adrenal and hypophysis glands. We aimed to use RSP for the differential diagnosis of parathyroid gland lesions.

Materials And Methods: In this study, we evaluated 97 parathyroid lesions in 85 patients, as well as 29 normal parathyroid glands. Read More

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http://dx.doi.org/10.1007/s40618-020-01239-zDOI Listing

Ectopic Cortisol-producing Adrenocortical Adenoma Detected by 131I-6 (-Iodomethyl-norcholesterol Scintigraphy.

Intern Med 2020 Apr 2. Epub 2020 Apr 2.

Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan.

A 50-year-old man was referred to our department for overt Cushing's syndrome (CS). His plasma cortisol concentrations were 314 μg/L, and his urinary cortisol concentrations were 431 μg/day. The plasma ACTH concentration was below the detectable limit. Read More

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http://dx.doi.org/10.2169/internalmedicine.4180-19DOI Listing

Role of Mast Cells in the Control of Aldosterone Secretion.

Horm Metab Res 2020 Mar 25. Epub 2020 Mar 25.

Normandie University, UNIROUEN, INSERM, DC2N, Rouen, France.

Mast cells are immune cells present in adrenals from various species. Proliferation and activation of adrenal mast cells seem to be influenced by environment, since they increase during summer and in response to sodium restriction in frogs and mouse, respectively. Although the physiological factors regulating adrenal mast cell activity have not been identified, they might involve neurotransmitters and the renin-angiotensin system. Read More

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http://dx.doi.org/10.1055/a-1119-1063DOI Listing

Imaging CXCR4 expression in patients with suspected primary hyperaldosteronism.

Eur J Nucl Med Mol Imaging 2020 Mar 23. Epub 2020 Mar 23.

Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.

Purpose: It is challenging to differentiate unilateral aldosterone-producing adenoma (APA) from bilateral idiopathic adrenal hyperplasia (IAH) and nonfunctional adrenal adenoma (NFA) in primary aldosteronism (PA). In a first primarily ex vivo study detection, CXC chemokine receptor type 4 (CXCR4) expression has been shown to be a valuable tool for the detection of APA. In this study, we aimed to clinically evaluate CXCR4 imaging with Ga-pentixafor PET/CT for detecting APA. Read More

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http://dx.doi.org/10.1007/s00259-020-04722-0DOI Listing

Adrenal incidentaloma: cardiovascular and metabolic effects of mild cortisol excess.

Gland Surg 2020 Feb;9(1):94-104

Department of Oncology and Metabolism, The Medical School, University of Sheffield, Beech Hill Road, Sheffield, UK.

In the vast majority of cases adrenal incidentalomas (AI) are benign adrenocortical adenomas. They are present in up to 10% of the population over 70 years, with incidence increasing with age. Mild cortisol excess (MCE) in the context of AI is defined as autonomous cortisol secretion (ACS) in the absence of the classical clinical features of Cushing's syndrome. Read More

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http://dx.doi.org/10.21037/gs.2019.11.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082271PMC
February 2020

Primary aldosteronism.

Gland Surg 2020 Feb;9(1):14-24

Department of General Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Primary aldosteronism (PA) is a common cause of secondary hypertension caused by excessive and inappropriate secretion of the hormone aldosterone from one or both adrenal glands. The prevalence of PA ranges from 10% in the general hypertensive population to 20% in resistant hypertension, yet only a small fraction of patients is diagnosed. Disease and symptom recognition, screening in indicated populations, multidisciplinary communication, and appropriate imaging and biochemical workup can identify patients who might benefit from effective and targeted treatment modalities. Read More

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http://dx.doi.org/10.21037/gs.2019.10.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082264PMC
February 2020

Primary aldosteronism diagnostics: mutations and hybrid steroid synthesis in aldosterone-producing adenomas.

Gland Surg 2020 Feb;9(1):3-13

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.

Primary aldosteronism (PA) is characterized by autonomous aldosterone production by renin-independent mechanisms and is most commonly sporadic. While 60-70% of sporadic PA can be attributed to bilateral hyperaldosteronism, the remaining 30-40% is caused by a unilateral aldosterone-producing adenoma (APA). Somatic mutations in or near the selectivity filter the gene (encoding the potassium channel GIRK4) have been implicated in the pathogenesis of both sporadic and familial PA. Read More

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http://dx.doi.org/10.21037/gs.2019.10.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082274PMC
February 2020

Immediate Results and Long-Term Outcomes Following Percutaneous Radiofrequency Ablation of Unilateral Aldosterone-Producing Adenoma.

Acta Cardiol Sin 2020 Mar;36(2):160-167

Division of Cardiology, Department of Internal Medicine.

Background: The aim of this study was to evaluate early and long-term clinical and laboratory findings in patients with resistant hypertension secondary to aldosterone-producing adenoma (APA) treated with radiofrequency ablation (RFA).

Methods: From July 2009 to September 2017, eight adult patients underwent percutaneous computed tomography (CT)-guided RFA for APA. The safety, efficacy and complications of the procedure were determined. Read More

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http://dx.doi.org/10.6515/ACS.202003_36(2).20190812CDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062809PMC

Adrenal Adenoma Anarchy: A Case of an ACTH-Secreting Pheochromocytoma.

Case Rep Endocrinol 2020 26;2020:4869467. Epub 2020 Feb 26.

Department of Medicine, Department of Endocrinology, San Antonio Military Medical Center, 3551 Roger Brooke Drive, JBSA Fort Sam Houston, San Antonio, TX 78234, USA.

. Pheochromocytomas are rare neuroendocrine tumors that arise from sympathetic adrenomedullary chromaffin tissue. Depending on the amount of catecholamines they secrete, they have variable presentations. Read More

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http://dx.doi.org/10.1155/2020/4869467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063192PMC
February 2020

Persistent severe hyperkalemia following surgical treatment of aldosterone-producing adenoma.

J Res Med Sci 2020 20;25:17. Epub 2020 Feb 20.

Department of Endocrinology, University of Medicine and Pharmacy "Grigore T. Popa", Iaşi, Romania.

Primary aldosteronism is one of the most common causes of secondary hypertension. This condition is characterized by autonomous hypersecretion of aldosterone which produces sodium retention and potassium excretion, resulting in high blood pressure and potential hypokalemia. Transient postoperative hyporeninemic hypoaldosteronism with an increased risk of hyperkalemia may occur in some patients. Read More

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http://dx.doi.org/10.4103/jrms.JRMS_603_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053163PMC
February 2020

Open adrenalectomy: A 20-year review of our experience in a developing country.

Ann Afr Med 2020 Jan-Mar;19(1):26-30

Department of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Farabi Hospital, Karadeniz Technical University, Trabzon, Turkey.

Introduction: The aim of this study was to present our 20-year experience regarding open adrenalectomy (OA) during laparoscopic era in a developing country Turkey.

Materials And Methods: A retrospective and descriptive study of patients with adrenal mass undergoing OA in the surgery department of our hospital, between January 1993 and January 2013, was carried out. All operations were performed by two surgeons. Read More

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http://dx.doi.org/10.4103/aam.aam_10_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189884PMC

An Incidental Diagnosis of Microscopic Renal Angiomyolipoma Completely Excised on Renal Biopsy: A Case Report.

Am J Case Rep 2020 Mar 15;21:e921353. Epub 2020 Mar 15.

Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.

BACKGROUND Microscopic tumor foci have been detected incidentally on renal biopsy, including renal cell carcinoma and renomedullary interstitial cell tumor (medullary fibroma). A report is presented of a case of an incidental finding of microscopic renal angiomyolipoma that was diagnosed and completely excised on core needle biopsy. CASE REPORT A 44-year-old woman was referred to our hospital for evaluation of persistent mild proteinuria. Read More

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http://dx.doi.org/10.12659/AJCR.921353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092777PMC

MicroRNAs and Adrenocortical Tumors: Where do we Stand on Primary Aldosteronism?

Horm Metab Res 2020 Mar 13. Epub 2020 Mar 13.

2nd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.

MicroRNAs, the endogenous mediators of RNA interference, interact with the renin-angiotensin-aldosterone system, regulate aldosterone secretion and aldosterone effects. Some novel data show that the expression of some microRNAs is altered in primary aldosteronism, and some of these appear to have pathogenic relevance, as well. Differences in the circulating microRNA expression profiles between the two major forms of primary aldosteronism, unilateral aldosterone-producing adenoma and bilateral adrenal hyperplasia have also been shown. Read More

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http://dx.doi.org/10.1055/a-1116-2366DOI Listing

Angiotensin II Type 1 Receptor Autoantibodies in Primary Aldosteronism.

Horm Metab Res 2020 Mar 13. Epub 2020 Mar 13.

Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Germany.

Primary aldosteronism (PA) is the most common form of endocrine hypertension. Agonistic autoantibodies against the angiotensin II type 1 receptor (ATR-Abs) have been described in transplantation medicine and women with pre-eclampsia and more recently in patients with PA. Any functional role of ATR-Abs in either of the two main subtypes of PA (aldosterone-producing adenoma or bilateral adrenal hyperplasia) requires clarification. Read More

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http://dx.doi.org/10.1055/a-1120-8647DOI Listing

Primary Aldosteronism Associated with Multiple Adrenocortical Micronodules in a Patient with Renal Cell Carcinoma.

Case Rep Endocrinol 2020 24;2020:2808101. Epub 2020 Feb 24.

Departments of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital Tokyo, Tokyo, Japan.

A 47-year-old woman with a history of diabetes mellitus (DM) and obesity was admitted to our hospital for glucose control. She was detected to have hypertension (HT) and diagnosed with primary aldosteronism (PA) based on the high level of aldosterone to renin ratio and the results of the upright furosemide-loading test according to the criteria of the Japanese Society of Hypertension (JSH) guidelines. Computed tomography revealed left renal tumor and adrenocortical adenoma. Read More

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http://dx.doi.org/10.1155/2020/2808101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060454PMC
February 2020

Comparison of synchronous bilateral transperitoneal and posterior retroperitoneal laparoscopic adrenalectomy: results of a multicenter study.

Surg Endosc 2020 Mar 9. Epub 2020 Mar 9.

Department of Urology, SLK Kliniken, University of Heidelberg, Heilbronn, Germany.

Background: Different techniques for laparoscopic adrenalectomy have been proposed with the lateral transperitoneal approach and posterior retroperitoneal approach being the two more frequently minimally invasive surgeries in most of the clinics. There are no sufficient studies in which the results of lateral transperitoneal and posterior retroperitoneal approaches in synchronous bilateral laparoscopic adrenalectomy have been compared. In the current study, we aimed to report our multicenter results of the lateral transperitoneal and posterior retroperitoneal synchronous bilateral laparoscopic adrenalectomy experience in patients who had different bilateral adrenal pathologies and to compare the outcomes of these two different operative procedures. Read More

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http://dx.doi.org/10.1007/s00464-020-07474-yDOI Listing

Expression of clock-related genes in benign and malignant adrenal tumors.

Endocrine 2020 Mar 8. Epub 2020 Mar 8.

1st Department of Internal Medicine, Laiko University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Although the effect of the central clock system on adrenal function has been extensively studied, the role of the peripheral clock system in adrenal tumorigenesis remains largely unexplored. In this study we investigated the expression of clock-related genes in normal adrenocortical tissue and adrenocortical tumors. Twenty-seven fresh frozen human adrenal tissues including 13 cortisol secreting adenomas (CSA), seven aldosterone producing adenomas (APA), and seven adrenocortical carcinomas (ACC) were collected. Read More

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http://dx.doi.org/10.1007/s12020-020-02246-zDOI Listing
March 2020
3.527 Impact Factor

Primary antiphospholipid syndrome, Addison disease, and adrenal incidentaloma.

Clin Rheumatol 2020 Jun 7;39(6):1997-2001. Epub 2020 Mar 7.

Direction of Education and Research, Hospital de Especialidades, Centro Médico Nacional "La Raza," IMSS, Seris y Zaachila S/N Col. La Raza CP, 02990, Mexico City, Mexico.

Primary adrenal failure comprises an insufficient production of mineralocorticoids and glucocorticoids in the adrenal cortex. A rare manifestation of antiphospholipid syndrome (APS) is adrenal failure. The majority of patients with adrenal involvement in APS develop an irreversible cortisol deficiency and atrophy of the adrenal glands. Read More

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http://dx.doi.org/10.1007/s10067-020-04978-9DOI Listing

Outcome in dogs undergoing adrenalectomy for small adrenal gland tumours without vascular invasion.

Vet Comp Oncol 2020 Mar 5. Epub 2020 Mar 5.

VCA Canada-404 Veterinary Emergency and Referral, Newmarket, Ontario, Canada.

Veterinary studies have reported the outcome of adrenalectomies in dogs; however, these studies typically include a wide variety of adrenal tumour sizes, including cases with or without vascular invasion. The purpose of this study was to report outcome in a cohort of dogs with histologically confirmed small adrenal tumours without vascular invasion treated with adrenalectomy. This retrospective study was conducted using data from the University of Florida and University of California-Davis databases between 2010 and 2017. Read More

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http://dx.doi.org/10.1111/vco.12587DOI Listing

Evolution of adrenal surgery in a tertiary referral centre.

Ir J Med Sci 2020 Mar 5. Epub 2020 Mar 5.

Department of Surgery, Cork University Hospital, Wilton, Cork, Ireland.

Background: Laparoscopic transperitoneal and retroperitoneoscopic adrenalectomy have largely replaced open adrenal surgery, particularly in benign disease. Laparoscopic surgery results in less post-operative pain, fewer surgical site complications and reduced length of hospital stay. The aim of this retrospective study was to analyse the characteristics of patients and evolution of surgical technique in adrenal surgery at Cork University Hospital over a 12-year period. Read More

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http://dx.doi.org/10.1007/s11845-020-02204-8DOI Listing

Tako-tsubo Syndrome as First Manifestation in a Case of Pheochromocytoma Developed From a Non-functional Adrenal Incidentaloma.

Front Endocrinol (Lausanne) 2020 14;11:51. Epub 2020 Feb 14.

Section of Endocrinology, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy.

Pheochromocytoma is a catecholamine secreting tumor that, in extremely rare cases, may develop over time from a non-functional adrenal adenoma. Catecholamine excess can lead to a kind of cardiomyopathy similar to that seen in tako-tsubo syndrome (TTS). A 69 years old female with a history of type 2 diabetes, hypertension, and a non-functional right adrenal adenoma diagnosed 3 years earlier was referred to our center for further investigations. Read More

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http://dx.doi.org/10.3389/fendo.2020.00051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033429PMC
February 2020