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    MANAGEMENT OF ENDOCRINE DISEASE: Diagnosis and Management of Primary Aldosteronism: the Endocrine Society guideline 2016 revisited.
    Eur J Endocrinol 2018 Apr 19. Epub 2018 Apr 19.
    M Reincke, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians- Universität München, München, Germany
    The syndrome of primary aldosteronism (PA) is characterized by hypertension with excessive, autonomous aldosterone production and is usually caused by either a unilateral aldosterone-producing adenoma (APA) or bilateral adrenal hyperplasia (BAH). The diagnostic workup of PA is a sequence of three phases comprising screening tests, confirmatory tests and the differentiation of unilateral from bilateral forms. The latter step is necessary to determine the optimal treatment approach of unilateral laparoscopic adrenalectomy (for patients with unilateral PA) or medical treatment with a mineralocorticoid receptor antagonist (for patients with bilateral PA). Read More

    Interobserver agreement in distinguishing large adrenal adenomas and adrenocortical carcinomas on computed tomography.
    Abdom Radiol (NY) 2018 Apr 19. Epub 2018 Apr 19.
    Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Purpose: Large adrenal masses pose a diagnostic dilemma. The purpose of this study was twofold: first, to assess the degree of interobserver agreement in evaluating the morphology of pathologically proven adrenal adenomas and adrenocortical carcinomas larger than 4 cm in diameter; and second, to identify morphologic characteristics that correlated with the pathologic diagnosis.

    Materials And Methods: For this blinded, retrospective study, we collected cases of 25 adrenal adenomas and 33 adrenocortical carcinomas measuring larger than 4 cm. Read More

    Activating PRKACB somatic mutation in cortisol-producing adenomas.
    JCI Insight 2018 Apr 19;3(8). Epub 2018 Apr 19.
    Cochin Institute, Paris Descartes University, CNRS (UMR 8104)/Inserm (U1016), Paris, France.
    Mutations in the gene encoding the protein kinase A (PKA) catalytic subunit α have been found to be responsible for cortisol-producing adenomas (CPAs). In this study, we identified by whole-exome sequencing the somatic mutation p.S54L in the PRKACB gene, encoding the catalytic subunit β (Cβ) of PKA, in a CPA from a patient with severe Cushing syndrome. Read More

    Histopathologic Findings in Canine Pituitary Glands.
    Vet Pathol 2018 Jan 1:300985818766211. Epub 2018 Jan 1.
    6 Department of Internal Medicine, Small Animal Hospital of Veterinary Faculty, University of Tehran, Tehran, Iran.
    To optimize the histologic evaluation of hypophysectomy specimens, sections of 207 canine pituitary glands (196 postmortem, 11 hypophysectomy specimens) were reviewed. Adenohypophyseal proliferation was the most common (n = 79) lesion. Proliferative lesions were sparsely to densely granulated; the granules were usually basophilic to chromophobic and periodic acid-Schiff-positive. Read More

    MiR-193a-3p functions as a tumour suppressor in human aldosterone-producing adrenocortical adenoma by down-regulating CYP11B2.
    Int J Exp Pathol 2018 Apr 17. Epub 2018 Apr 17.
    Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
    The mechanism of aldosterone-producing adrenocortical adenoma (APA) pathogenesis and the role of microRNAs (miRNAs) in APA pathogenesis have not been completely clarified. We examined the expression and function of miR-140-3p, miR-193a-3p and miR-22-3p, which have binding sites in CYP11B2. Expression of miRNAs and CYP11B2 mRNA was measured by quantitative reverse transcription PCR (qRT-PCR). Read More

    Integrated Imaging Characterization of Adrenal Adenoma: False-Positive Metaiodobenzylguanidine (MIBG) Findings of Adrenal Scintigraphy.
    Pol J Radiol 2017 4;82:422-425. Epub 2017 Aug 4.
    Department of Advanced Biomedical Sciences, University "Federico II", Naples, Italy.
    Background: Evaluation of a patient with melanoma in whom an adrenal mass was detected on CT and MR during follow-up and further characterized with PET-CT and MIBG scintigraphy.

    Case Report: In this case report, we describe a patient with melanoma in whom an adrenal mass was detected on CT and MRI during post-surgical follow-up and was further characterized with radionuclide studies consisting of PET-CT and MIBG scintigraphy. Although the results of imaging studies suggested that the mass was a pheochromocytoma, a cortical adrenal adenoma was histologically proven. Read More

    Are Cushing's disease patients curable?
    Ann Endocrinol (Paris) 2018 Apr 9. Epub 2018 Apr 9.
    Service des maladies endocriniennes et métaboliques, centre de référence des maladies rares de la surrénale, hôpital Cochin, faculté de médecine Paris-Descartes, université Paris 5, 24, rue du Faubourg-St-Jacques, 75014 Paris, France. Electronic address:
    Treatment of Cushing's disease remains a challenge. Whereas pituitary surgery can "cure" the patient and restore a completely normal pituitary adrenal axis, there are immediate failures and late recurrences which ultimately require alternate therapeutic approaches. These are numerous, but so are their drawbacks, and all appear to be "default options". Read More

    The Lateralizing Asymmetry of Adrenal Adenomas.
    J Endocr Soc 2018 Apr 16;2(4):374-385. Epub 2018 Mar 16.
    Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts.
    Context: It is presumed that the incidence of adrenal adenomas is symmetric between the left and right adrenal gland; however, anecdotal observations suggest a potential lateralizing asymmetry.

    Objective: To investigate the symmetry in detection of adrenal adenomas and relevance to patient care.

    Design: Cross-sectional and longitudinal studies. Read More

    Comparative Genomics and Transcriptome Profiling in Primary Aldosteronism.
    Int J Mol Sci 2018 Apr 9;19(4). Epub 2018 Apr 9.
    Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, 80336 Munich, Germany.
    Primary aldosteronism is the most common form of endocrine hypertension with a prevalence of 6% in the general population with hypertension. The genetic basis of the four familial forms of primary aldosteronism (familial hyperaldosteronism FH types I-IV) and the majority of sporadic unilateral aldosterone-producing adenomas has now been resolved. Familial forms of hyperaldosteronism are, however, rare. Read More

    Rebound thymic hyperplasia after adrenalectomy in a patient with Cushing syndrome caused by adrenocortical adenoma: A case report.
    Medicine (Baltimore) 2018 Apr;97(15):e0367
    Department of Pediatrics, Chonbuk National University Medical School.
    Rationale: The development of rebound thymic hyperplasia (RTH) has been reported in patients who have recovered from stressful conditions such as surgery and steroid therapy. We report a case of RTH following the resolution of hypercortisolism after adrenalectomy for the treatment of adrenocortical adenoma in a patient with Cushing syndrome.

    Patient Concerns: A 5-month-old female infant with a history of overeating, hirsutism, and excessive weight gain for the previous 2 months was referred to the hospital. Read More

    The Spectrum of Thyroid Gland Pathology in Carney Complex: The Importance of Follicular Carcinoma.
    Am J Surg Pathol 2018 May;42(5):587-594
    Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
    The initial description of Carney complex (CNC) in 1985 included myxomas, spotty skin pigmentation, and endocrine overactivity (of the adrenal, the pituitary, and the testis). In 1997, thyroid neoplasms were found in 3 patients with CNC and involvement of the gland in the syndrome was apparent. Herein, we describe the clinical, pathologic, and follow-up findings in 26 patients with CNC and a disorder of the thyroid gland. Read More

    Concurrent primary hyperparathyroidism and pheochromocytoma in a Chinese lady with neurofibromatosis type 1.
    Endocrinol Diabetes Metab Case Rep 2018 28;2018. Epub 2018 Mar 28.
    Department of Medicine and Geriatrics, Caritas Medical Centre, Shamshuipo, Kowloon, Hong Kong SAR.
    We report a case of elderly Chinese lady with neurofibromatosis type-1 presenting with longstanding palpitation, paroxysmal hypertension and osteoporosis. Biochemical testing showed mild hypercalcaemia with non-suppressed parathyroid hormone level suggestive of primary hyperparathyroidism, and mildly elevated urinary fractionated normetanephrine and plasma-free normetanephrine pointing to a catecholamine-secreting pheochromocytoma/paraganglioma. Further scintigraphic investigation revealed evidence of a solitary parathyroid adenoma causing primary hyperparathyroidism and a left pheochromocytoma. Read More

    Adrenal gland tumors in dairy cattle from Northern Italy: morphological and phenotypical characterization in comparison with human pathology.
    Pol J Vet Sci 2017 Dec;20(4):779-788
    Department of Oncology, San Luigi Hospital, University of Torino, Orbassano, Torino, Italy.
    Bovine adrenal gland tumours are considered relatively common, although scarce data are available about their real incidence, pathological characterization, classification criteria and immunohistochemical profile. This study describes the morphological and immunophenotypical characteristics of 35 dairy cattle adrenal gland tumors from Northern Italy and compare them with human pathology. Macroscopical, histological, histochemical and immunohistochemical investigations were performed. Read More

    Tumor Microenvironment in Functional Adrenocortical Adenomas: Immune Cell Infiltration in Cortisol-producing Adrenocortical Adenoma.
    Hum Pathol 2018 Mar 26. Epub 2018 Mar 26.
    Department of Pathology of Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address:
    The tumor microenvironment plays pivotal roles in various human neoplasms. However, that of benign tumor, particularly hormone-secreting endocrine tumors, has remained virtually unknown. Therefore, we firstly attempted to analyze the tumor microenvironment of autonomous hormone-secreting adrenocortical adenomas. Read More

    The Many Faces of Primary Aldosteronism and Cushing Syndrome: A Reflection of Adrenocortical Tumor Heterogeneity.
    Front Med (Lausanne) 2018 12;5:54. Epub 2018 Mar 12.
    Department of Pathology, University Health Network, Toronto, ON, Canada.
    Adrenal cortical tumors constitute a heterogeneous group of neoplasms with distinct clinical, morphological, and molecular features. Recent discoveries of specific genotype-phenotype correlations in adrenal cortical adenomas have transformed our understanding of their respective endocrine syndromes. Indeed, a proportion of patients with primary aldosteronism are now known to harbor adrenal cortical adenomas with heterogeneous molecular alterations (, and ) involving the calcium/calmodulin kinase signaling pathway. Read More

    An unusual case of hematemesis and epistaxis caused by a pheochromocytoma.
    J Int Med Res 2018 Jan 1:300060518765015. Epub 2018 Jan 1.
    6 Department of Medical Biochemistry (Firat Hormones Research Group), School of Medicine, Firat University, Elazig, Turkey.
    Pheochromocytoma is a rare catecholamine-secreting neoplasm that is the cause of hypertension in <0.2% of patients with hypertension. We encountered an unusual case of pheochromocytoma involving hematemesis and epistaxis episodes with accompanying hypertensive attacks. Read More

    Clock genes alterations and endocrine disorders.
    Eur J Clin Invest 2018 Mar 25:e12927. Epub 2018 Mar 25.
    1st Department of Propaedeutic Internal Medicine, Medical School, Laikon Hospital, National and Kapodistrian University of Athens, Athens, Greece.
    Background: Various endocrine signals oscillate over the 24-hour period and so does the responsiveness of target tissues. These daily oscillations do not occur solely in response to external stimuli but are also under the control of an intrinsic circadian clock.

    Design: We searched the PubMed database to identify studies describing the associations of clock genes with endocrine diseases. Read More

    Worse Health-Related Quality of Life at long-term follow-up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN.
    Clin Endocrinol (Oxf) 2018 Mar 24. Epub 2018 Mar 24.
    Institute of Medicine at Sahlgrenska Academy, University of Gothenburg and the Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Objective: Hypercortisolism in Cushing's syndrome (CS) is associated with impaired health-related quality of life (HRQoL), which may persist despite remission. We used the data entered into the European Registry on Cushing's syndrome (ERCUSYN) to evaluate if patients with CS of pituitary origin (PIT-CS) have worse HRQoL, both before and after treatment than patients with adrenal causes (ADR-CS).

    Methods: Data from 595 patients (492 women; 83%) who completed the CushingQoL and/or EQ-5D questionnaires at baseline and/or following treatment were analysed. Read More

    Pheochromocytomas Versus Adenoma: Role of Venous Phase CT Enhancement.
    AJR Am J Roentgenol 2018 Mar 23:1-6. Epub 2018 Mar 23.
    1 Department of Radiology, Vancouver General Hospital, 899 W 12th Ave, Vancouver, BC V5Z 1M9, Canada.
    Objective: Our objective was to investigate whether the quantitative measurement of venous phase enhancement on CT can distinguish a pheochromocytoma from an adrenal adenoma.

    Materials And Methods: A pathology database was retrospectively appraised over a period of 7 years and revealed 43 histopathologically proven adrenal adenomas and 34 pheochromocytomas. The lesion densities were measured on the 60-second venous phase CT on all adrenal lesions to assess venous phase enhancement values. Read More

    Value of pituitary gland MRI at 7 T in Cushing's disease and relationship to inferior petrosal sinus sampling: case report.
    J Neurosurg 2018 Mar 23:1-5. Epub 2018 Mar 23.
    Neurosurgery, Keck School of Medicine; and.
    Cushing's disease is caused by adrenocorticotrophic hormone (ACTH)-secreting pituitary adenomas, which are often difficult to identify on standard 1.5-T or 3-T MRI, including dynamic contrast imaging. Inferior petrosal and cavernous sinus sampling remains the gold standard for MRI-negative Cushing's disease. Read More

    Adrenal Hemangioma Definite Diagnosis on CT, MRI, and FDG PET in a Patient With Primary Lung Cancer.
    Clin Nucl Med 2018 Mar 20. Epub 2018 Mar 20.
    Distinguishing adrenal incidentalomas (5% of all abdominal CT scans) from metastasis is a frequent diagnostic challenge in primary malignancies with a propensity for adrenal spread, such as lung cancer. Adrenal myelolipoma and adenoma can be definitively characterized as benign by demonstrating gross and microscopic fat, respectively, on CT and MRI and an absence of abnormal uptake on PET. Unfortunately, adrenal sampling is frequently necessary in indeterminate cases for adequate staging of extra-adrenal primary malignancy. Read More

    Arterial stiffness evaluated by pulse wave velocity is not predictive of the improvement in hypertension after adrenal surgery for primary aldosteronism: A multicentre study from the French European Society of Hypertension Excellence Centres.
    Arch Cardiovasc Dis 2018 Mar 16. Epub 2018 Mar 16.
    Department of Therapeutics and Hypertension, Rangueil University Hospital, 31059 Toulouse, France.
    Background: Predictive factors associated with normal blood pressure (BP) after unilateral adrenalectomy for primary aldosteronism (PA) are not clearly identified.

    Aims: To evaluate the predictive value of arterial stiffness before surgery on BP after surgery.

    Methods: During 2009-2013, 96 patients with PA due to unilateral adrenal adenoma who underwent surgery were enrolled in a multicentre open-label, prospective study. Read More

    Surgical Outcomes of Patients with Beckwith-Wiedemann Syndrome.
    J Pediatr Surg 2018 Feb 12. Epub 2018 Feb 12.
    Division of Pediatric Surgery, The Michael E. DeBakey Department of Surgery, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, United States. Electronic address:
    Purpose: The purpose of this study was to evaluate treatment and surgical outcomes of patients of Beckwith-Wiedemann Syndrome (BWS) treated at a tertiary children's hospital.

    Methods: A retrospective review of infants evaluated at Texas Children's Hospital for BWS from August 2000 to December 2016 was performed. Data collected included demographic information, clinical presentation, genetic evaluation, fetal imaging, operative treatment, and outcomes. Read More

    Does IGF-1 play a role in the etiopathogenesis of non-functioning adrenocortical adenoma?
    J Endocrinol Invest 2018 Mar 14. Epub 2018 Mar 14.
    Department of Endocrinology and Metabolism, Faculty of Medicine, Ondokuz Mayis University, Kurupelit, 55139, Samsun, Turkey.
    Purpose: The aim of this study was to investigate the possible association of insulin-like growth factor-1 (IGF-1) with the pathogenesis of non-functioning adrenocortical adenomas (NFAs).

    Methods: This study included 50 female patients (mean age 54 years) with NFAs, 55 patients (mean age 48 years; 20 male, 35 female) with acromegaly and 38 female control subjects (mean age 58 years). Body mass index (BMI) and waist circumference (WC) of the subjects were recorded and blood samples for IGF-1 were taken. Read More

    Secreting ectopic adrenal adenoma: A rare condition to be aware of.
    Ann Endocrinol (Paris) 2018 Apr 7;79(2):75-81. Epub 2018 Mar 7.
    Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong, University School of Medicine, Xi'an, Shannxi 710061, PR China. Electronic address:
    Ectopic adrenal adenoma causing chronic Cushing's syndrome (CS) is a rare phenomenon. Diagnosis is usually made years after disease onset because of the insidious nature of the ectopic adrenal gland and because it overlaps with common symptoms, such as overweight and hypertension, in the general population (Kreitschmann-Andermahr et al., 2015). Read More

    MANAGEMENT OF ENDOCRINE DISEASE: Management of Cushing's syndrome during Pregnancy: solved and unsolved questions.
    Eur J Endocrinol 2018 Mar 9. Epub 2018 Mar 9.
    F Castinetti, Department of endocrinology, Aix-Marseille université, Assistance-Publique-Hôpitaux de Marseille, centre de référence des maladies rares d'origine hypophysaire, Marseille, 13005, France.
    With fewer than 200 reported cases, Cushing's syndrome (CS) in pregnancy remains a diagnostic and therapeutic challenge. In normal pregnancies, misleading signs may be observed such as striae or hypokalemia, while plasma cortisol and urinary free cortisol may rise up to 2-3-fold. While the dexamethasone suppression test is difficult to use, reference values for salivary cortisol appear valid. Read More

    A Young Patient with Leg Weakness and Hypokalemia-Case Report.
    Rambam Maimonides Med J 2018 Feb 1:1-5. Epub 2018 Feb 1.
    Department of Internal Medicine B, Rambam Health Care Campus, Haifa, Israel.
    A 20-year-old female patient was admitted to hospital because of bilateral leg weakness. Laboratory investigation showed metabolic alkalosis and severe hypokalemia. Differential diagnosis included mineralocorticoid or apparent mineralocorticoid excess diseases, with a high aldosterone-to-renin ratio (ARR) after correcting hypokalemia. Read More

    Targeted treatment of primary aldosteronism - The consensus of Taiwan Society of Aldosteronism.
    J Formos Med Assoc 2018 Mar 2. Epub 2018 Mar 2.
    Division of Cardiology, National Taiwan University Hospital, Taipei, Taiwan.
    Background/purpose: Even with the increasing recognition of primary aldosteronism (PA) as a cause of refractory hypertension and an issue of public health, the consensus of its optimal surgical or medical treatment in Taiwan has not been reached. Our objective was to develop a clinical practice guideline that is feasible for real-world management of PA patients in Taiwan.

    Methods: The Taiwan Society of Aldosteronism (TSA) Task Force recognized the above-mentioned issues and reached this Taiwan PA consensus at its inaugural meeting, in order to provide updated information of internationally acceptable standards, and also to incorporate our local disease characteristics and constraints into PA management. Read More

    Plurihormonal ACTH-GH Pituitary Adenoma: Case Report and Systematic Literature Review.
    World Neurosurg 2018 Mar 6. Epub 2018 Mar 6.
    Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy. Electronic address:
    Background: Plurihormonal adenomas (PHAs) represent 10%-15% of all functioning pituitary adenomas. The most frequent hormonal associations are with prolactin and growth hormone (GH). Here we describe a rare case of functional adrenocorticotropic hormone (ACTH) and GH microadenoma and report our findings from a systematic literature review of PHA. Read More

    A black adrenal adenoma with high FDG uptake on PET/CT scan in a patient with esophageal carcinoma: A case report.
    Int J Surg Case Rep 2018 7;44:118-121. Epub 2017 Dec 7.
    Department of Surgery, Jichi Medical University, Tochigi, Japan.
    Introduction: Black adrenal adenoma (BAA) is a rare, benign adrenal lesion with a black or brown appearance. This is the first report of this lesion in a patient with a synchronous esophageal cancer and highlights the importance of considering a false positive finding on a Positron Emission Tomography (PET) scan, which might otherwise preclude resection.

    Presentation Of Case: A 73-year-old male was diagnosed with mid-esophagus carcinoma. Read More

    MANAGEMENT OF ENDOCRINE DISEASE: Can we cure Cushing's disease? A personal view.
    Eur J Endocrinol 2018 May 21;178(5):R183-R200. Epub 2018 Feb 21.
    Service des Maladies Endocriniennes et MétaboliquesCentre de Référence des Maladies Rares de la Surrénale, Hôpital Cochin, Faculté de Médecine Paris Descartes, Université Paris 5, Paris, France
    One of today's challenges in endocrinology is the treatment of Cushing's disease: Although pituitary surgery has the potential to 'cure' the patient and restore a completely normal pituitary adrenal axis, there are immediate failures and late recurrences that will ultimately require alternate therapeutic approaches. Their high number is in direct correlation with their serious limitations and they all appear to be 'default options'. This 'personal view' tries to shed some light on the inescapable difficulties of the current treatments of Cushing's disease and to provide some optimistic view for the future where the pituitary adenoma should be the 'reasonable obsession' of a successful therapeutist. Read More

    A short review of primary aldosteronism in a question and answer fashion.
    Endocr Regul 2018 Jan;52(1):27-40
    5Resident Surgeon, 3rd Department of Surgery, Attikon University Hospital, University of Athens School of Medicine , Athens , Greece.
    Objectives: The aim of this study was to present up to date information concerning the diagnosis and treatment of primary aldosteronism (PA). PA is the most common cause of endocrine hypertension. It has been reported up to 24% of selective referred hypertensive patients. Read More

    The angiotensin type 2 receptor in the human adrenocortical zona glomerulosa and in aldosterone-producing adenoma: low expression and no functional role.
    Clin Sci (Lond) 2018 Mar 20;132(6):627-640. Epub 2018 Mar 20.
    Clinica dell'Ipertensione Arteriosa, Department of Medicine-DIMED, University of Padova, Italy
    The angiotensin II (Ang II) type 2 receptor (AT2R) and the angiotensin-(1-7) (Ang-(1-7)) receptor (MasR) play a cardiovascular protective role by counter-regulating Ang II type 1 receptor (AT1R)-mediated effects, but whether this involves blunting of adrenocortical hormone secretion is unknown. We investigated the presence of AT1R, AT2R, and MasR in aldosterone-producing adenoma (APA), a condition featuring hyperaldosteronism, and in APA-adjacent tissue. The effect of Compound 21 (C21), an AT2R agonist, on CYP11B1 (cortisol synthase) and CYP11B2 (aldosterone synthase) gene expression in NCI-H295R and HAC15 cell lines, and in APA and APA-adjacent tissue, was also assessed using the AT1R antagonist irbesartan to ascertain the specificity of C21 effect. Read More

    Common module analysis reveals prospective targets and mechanisms of pediatric adrenocortical adenoma and carcinoma.
    Oncol Lett 2018 Mar 19;15(3):3267-3272. Epub 2017 Dec 19.
    Department of Applied Sciences, Indian Institute of Information Technology, Allahabad, Uttar Pradesh 211012, India.
    Pediatric adrenocortical carcinoma and adrenocortical adenoma are two rare diseases affecting children. Molecular analyses were performed to identify commonalities in gene expression between the diseases. Differentially expressed genes were identified for the pediatric adrenocortical adenoma and carcinoma tissues, as compared with normal tissues, using the expression dataset. Read More

    Overview of aldosterone-related genetic syndromes and recent advances.
    Curr Opin Endocrinol Diabetes Obes 2018 Feb 8. Epub 2018 Feb 8.
    INSERM, UMRS_970, Paris Cardiovascular Research Center.
    Purpose Of Review: Primary aldosteronism is the most common form of secondary hypertension. Early diagnosis and treatment are key to cure of hypertension and prevention of cardiovascular complications. Recent genetic discoveries have improved our understanding on the pathophysiology of aldosterone production and triggered the development of new diagnostic procedures and targeted treatments for primary aldosteronism. Read More

    [Pathogenic and diagnostic roles of microRNAs in adrenocortical tumours].
    Orv Hetil 2018 Feb;159(7):245-251
    II. Belgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Szentkirályi u. 46., 1088.
    Adrenocortical tumours are quite prevalent. Most of these tumours are benign, hormonally inactive adrenocortical adenomas. Rare hormone-secreting adrenocortical adenomas are associated with severe clinical consequences, whereas the prognosis of the rare adrenocortical cancer is rather poor in its advanced stages. Read More

    Testosterone- and Cortisol-secreting Oncocytic Adrenocortical Adenoma in the Pediatric Age-group.
    Pediatr Dev Pathol 2018 Jan 1:1093526617753045. Epub 2018 Jan 1.
    3 College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
    Oncocytic tumors are epithelial neoplasms that occur in various organs, including adrenal glands. Oncocytic adrenocortical adenomas and carcinomas are uncommon but well-known pathological entities in adults. However, generally oncocytic tumors, particularly in the adrenal glands, are very rare in the pediatric age-group. Read More

    Adrenal Axis Insufficiency After Endoscopic Transsphenoidal Resection of Pituitary Adenomas.
    World Neurosurg 2018 Apr 5;112:e869-e875. Epub 2018 Feb 5.
    Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, California, USA.
    Introduction: Hormonal insufficiency of 1 or more pituitary axes can appear after pituitary surgery. Adrenal axis impairment after surgery can lead to serious consequences if not identified and treated.

    Objective: Assess early and late postoperative adrenal insufficiency (AI) and identify the risk factors predicting their occurrence after endoscopic transsphenoidal resection of pituitary adenomas. Read More

    [Clinical report of testicular hypoplasia combined with 21-hydroxylase deficiency].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2018 Feb;35(1):29-33
    Reproductive Center, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, Guangxi 541002, China; Reproductive Medicine Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China. Email:
    OBJECTIVE To investigate the correlation of 21-hydroxylase deficiency (21-OHD) with male testicular dysplasia. METHODS Clinical data of 8 infertile males with congenital adrenal hyperplasia due to 21-OHD was retrospectively analyzed. In addition, potential mutations of the CYP21A2 gene was detected. Read More

    Long-term follow-up and novel splice donor mutation in in a Chinese family.
    Oncotarget 2018 Jan 7;9(2):1577-1586. Epub 2017 Dec 7.
    Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha, China.
    Heterozygous germline mutation of the tumor suppressor gene is responsible for multiple endocrine neoplasia type 1. Parathyroid and thoracic neuroendocrine tumor specimens and DNA from two Han Chinese MEN1 family patients were analyzed using whole exome and Sanger sequencing. The proband (II-3) was sequentially diagnosed with pituitary adenoma, pancreatic tumor, adrenal cortical tumor, abdominal lipoma, and parathyroid adenoma during the 6-year follow-up. Read More

    A First Report of Synchronous Intracapsular and Extracapsular Hepatic Adenoma.
    Case Rep Surg 2017 19;2017:9053568. Epub 2017 Dec 19.
    Medical Faculty, Department of General Surgery, Ondokuz Mayis University, Samsun, Turkey.
    Although the gallbladder is the most common site of ectopic liver, it has been reported in many other organs, such as kidney, adrenal glands, pancreas, omentum, stomach, esophagus, mediastinum, lungs, and heart. Hepatocytes in an ectopic liver behave like normal hepatocytes; furthermore, they can be associated with the same pathological findings as those in the main liver. Ectopic liver in the gallbladder can undergo fatty change, hemosiderosis, cholestasis, cirrhosis, hemangioma, focal nodular hyperplasia, adenoma, and even carcinogenesis. Read More

    Macrolides for KCNJ5-mutated aldosterone-producing adenoma (MAPA): design of a study for personalized diagnosis of primary aldosteronism.
    Blood Press 2018 Feb 6:1-6. Epub 2018 Feb 6.
    a Department of Medicine-DIMED, Clinica dell'Ipertensione Arteriosa , University of Padova , Padova , Italy.
    Purpose: Aldosterone-producing adenoma (APA) is the main curable cause of endocrine hypertension cause of primary aldosteronism (PA) and it is in up to 66% of all cases investigated with adrenal vein sampling (AVS). Mutations in the KCNJ5 potassium channel involve up to 70% of APA and cause the most florid PA phenotypes. The recent finding that macrolide antibiotics specifically inhibit in vitro the altered function of mutated KCNJ5 channels has opened new horizons for the diagnosis and treatment of APA with KCNJ5 mutations in that it can allow identification and target treatment of PA patients harbouring a mutated APA. Read More

    Operative technique: Transperitoneal robotic adrenalectomy.
    J Visc Surg 2018 Feb 1;155(1):50-58. Epub 2018 Feb 1.
    Service de chirurgie digestive, hépatobiliaire, endocrinienne, et cancérologique, Hospital Brabois-Adultes, université de Lorraine, CHU de Nancy, 11, allée du Morvan, 54511 Vandœuvre-les-Nancy, France; Unité Inserm U954 « Nutrition - génétique et exposition aux risques environnementaux », faculté de médecine, université de Lorraine, 54511 Vandœuvre-les-Nancy, France. Electronic address:

    Robot-assisted laparoendoscopic single site adrenalectomy: A comparison of 3 different port platforms with 3 case reports.
    Medicine (Baltimore) 2017 Dec;96(51):e9479
    Department of Surgery, Division of Urology, Chang Gung Memorial Hospital at Linkou, Taoyuan.
    Rationale: Laparoscopic adrenalectomy is currently the standard of care for adrenal lesion. Minimal invasive laparoscopic surgery such as laparoendoscopic single site surgery (LESS) and natural orifice transluminal endoscopic surgery (NOTES) have been developed to improve cosmetic outcomes and reduce postoperative pain. However, there are still some problems related to instruments and port limitation during LESS surgery. Read More

    Case report of a bilateral adrenal myelolipoma associated with Cushing disease.
    Medicine (Baltimore) 2017 Dec;96(52):e9455
    Division of Endocrinology and Metabolism, Departments of Internal Medicine.
    Rationale: Adrenal myelolipomas are rare benign tumors, composed of a variable mixture of mature adipose tissue and hematopoietic tissue. These tumors are frequently detected incidentally and are usually asymptomatic, and hormonally inactive.

    Patient Concerns: During a routine health checkup, a 52-year-old man was found to have a tumor on the bilateral adrenal glands. Read More

    Multiple Salivary Cortisol Measurements Are a Useful Tool to Optimize Metyrapone Treatment in Patients with Cushing's Syndromes Treatment: Case Presentations.
    Front Endocrinol (Lausanne) 2017 11;8:375. Epub 2018 Jan 11.
    Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan.
    Measuring salivary cortisol is both convenient and non-invasive for patients; however, its usefulness as a marker for monitoring medical therapy has not yet been established. The aim of this study was to assess the utility of multiple salivary cortisol measurements in patients with Cushing's syndrome (CS) during medical therapy. Six patients with CS (three with cortisol-secreting adrenocortical adenoma and three with ACTH-secreting pituitary adenoma) were recruited. Read More

    CyberKnife Radiosurgery in the Multimodal Management of Patients with Cushing Disease.
    World Neurosurg 2018 Apr 31;112:e425-e430. Epub 2018 Jan 31.
    Department of Neurosurgery, Stanford Medical Center, Stanford University, Palo Alto, California, USA; Department of Medicine, Stanford Medical Center, Stanford University, Palo Alto, California, USA. Electronic address:
    Background: Surgery is the primary treatment for Cushing disease. When surgery is unsuccessful in normalizing hypercortisolism, adjuvant radiation, such as stereotactic radiosurgery, may be useful to improve biochemical control.

    Methods: This retrospective study included a cohort of consecutive patients treated with CyberKnife (CK) radiosurgery for active Cushing disease at Stanford Hospital and Clinics. Read More

    Who was Dr. William C. Baum?
    World J Surg 2018 Jan 19. Epub 2018 Jan 19.
    Department of Surgery, University of Virginia School of Medicine, P O Box 800709, Charlottesville, VA, 22908, USA.
    The first discovery of primary hyperaldosteronism secondary to an aldosterone-secreting adrenal adenoma has been credited solely to Dr. Jerome Conn, an endocrinologist at the University of Michigan and for whom, Conn syndrome was named. Dr. Read More

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