7,963 results match your criteria Adrenal Adenoma


Expression of aldosterone synthase CYP11B2 was inversely correlated with longevity.

J Steroid Biochem Mol Biol 2019 Apr 8. Epub 2019 Apr 8.

Department of Uro-Oncology, Saitama Medical University International Medical Center, Saitama, Japan; Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan. Electronic address:

Immunohistochemistry of human aldosterone synthase (CYP11B2) has revealed that most of aldosterone is autonomously produced in aldosterone-producing cell clusters (APCCs) beneath the capsule of adult adrenals rather than physiologically in the zona glomerulosa (ZG). APCCs have been occasionally found to harbor a somatic mutation of ion channel/pump genes, and number and size of APCCs increase with age until 50 years old. Herein, the objective of the study was to examine APCC development in 106 autopsied adrenals from 85 elderly individuals who died at ages from 50 to 103 years. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2019.04.010DOI Listing
April 2019
2 Reads

A successful pregnancy in a patient with secondary hypertension caused by adrenal adenoma: a case report.

BMC Pregnancy Childbirth 2019 Apr 3;19(1):116. Epub 2019 Apr 3.

Department of cardiology, West China Hospital, Sichuan University, Chengdu, China.

Background: Secondary hypertension is a rare complication in pregnancy that causes poor outcomes, such as preeclampsia, premature delivery, intrauterine growth retardation, stillbirths, spontaneous abortion or intrauterine death. Cushing's disease caused by an adrenal adenoma is rare during pregnancy and may be overlooked by obstetricians and physicians, but can lead to hypertension, diabetes mellitus and an increased risk of fetal and maternal morbidity. Approximately 200 cases have been reported in the literature. Read More

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http://dx.doi.org/10.1186/s12884-019-2262-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448298PMC
April 2019
2 Reads

Comparison of plasma and urinary microRNA-483-5p for the diagnosis of adrenocortical malignancy.

J Biotechnol 2019 May 30;297:49-53. Epub 2019 Mar 30.

2nd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Szentkirályi str. 46., 1088 Budapest, Hungary; MTA-SE Molecular Medicine Research Group, Hungarian Academy of Sciences and Semmelweis University, Szentkirályi str. 46., 1088 Budapest, Hungary. Electronic address:

Introduction: Minimally invasive circulating microRNAs might be used for the preoperative differentiation of adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA). So far, the best blood-borne microRNA biomarker of ACC is circulating hsa-miR-483-5p. The expression of urinary hsa-miR-483-5p as a non-invasive marker of malignancy and its correlation with plasma hsa-miR-483-5p, has not been investigated, yet. Read More

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http://dx.doi.org/10.1016/j.jbiotec.2019.03.017DOI Listing
May 2019
3 Reads

Adrenocortical hypofunction with simultaneous primary aldosteronism: A case report.

Medicine (Baltimore) 2019 Mar;98(13):e15033

Rationale: Cases of adrenocortical hyperfunction combined with primary aldosteronism have been reported in the literature, and the underlying mechanism involves the secretion of aldosterone and glucocorticoids by a tumor or an adenoma. However, adrenocortical hypofunction and coexisting primary aldosteronism have not been reported until now. Herein, we report a case of adrenocortical hypofunction combined with primary aldosteronism. Read More

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http://dx.doi.org/10.1097/MD.0000000000015033DOI Listing
March 2019
3 Reads

Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing's Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China.

Int J Endocrinol 2019 19;2019:7159696. Epub 2019 Feb 19.

Key Laboratory of Endocrinology of National Health Commission of People's Republic of China, Beijing 100730, China.

Purpose: To investigate the demographic characteristics, etiology, and comorbidities of Cushing's syndrome (CS) patients at a large medical center in China.

Methods: Records on CS patients discharged from 2008 to 2017 were retrieved from the hospital discharge abstract database (DAD) using ICD-10 codes. Demographic characteristics, etiology, and comorbidity data were analyzed. Read More

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http://dx.doi.org/10.1155/2019/7159696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399544PMC
February 2019
2 Reads
1.515 Impact Factor

Unmasking of Sarcoidosis After Successful Management of Cushing's Syndrome.

Cureus 2019 Jan 16;11(1):e3896. Epub 2019 Jan 16.

Endocrinology, Universidad De Antioquia, Medellin, COL.

Cushing's syndrome is characterized by excessive glucocorticoid secretion leading to immunosuppression. The unmasking or aggravation of autoimmune diseases upon the normalization of cortisol levels after Cushing's syndrome cure has been reported infrequently. The case of a 45-year-old woman who presented with an 11-month history of severe signs and symptoms of hypercortisolism is reported. Read More

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http://dx.doi.org/10.7759/cureus.3896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424549PMC
January 2019
3 Reads

Double trouble: two cases of dual adrenal pathologies in one adrenal mass.

Endocrinol Diabetes Metab Case Rep 2019 Mar 23;2019. Epub 2019 Mar 23.

St. Vincent's University Hospital and University College Dublin, Dublin, Ireland.

Context Adrenal incidentalomas (AI) represent an increasingly common problem in modern endocrine practice. The diagnostic approach to AIs can be challenging and occasionally reveals surprising features. Here we describe two rare cases of complex adrenal lesions consisting of phaeochromocytomas with synchronous metastases from extra-adrenal primaries. Read More

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http://dx.doi.org/10.1530/EDM-18-0151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432979PMC
March 2019
1 Read

Spectral CT and its specific values in the staging of patients with non-small cell lung cancer: technical possibilities and clinical impact.

Clin Radiol 2019 Mar 21. Epub 2019 Mar 21.

Department of Radiology, Charité University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany; Department of Radiology, University Hospital Munich, Ludwig-Maximilians University (LMU), Munich, Germany. Electronic address:

Aim: To investigate how spectral computed tomography (SCT) values impact the staging of non-small cell lung cancer (NSCLC) patients.

Materials And Methods: One hundred and thirteen patients with confirmed NSCLC were included in a prospective cohort study. All patients underwent single-phase contrast-enhanced SCT (using the fast tube voltage switching technique, 80-140 kV). Read More

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http://dx.doi.org/10.1016/j.crad.2019.02.010DOI Listing
March 2019
1 Read

Adrenal adenoma in von Hippel-Lindau syndrome: A case report with review of literature.

J Cancer Res Ther 2019 Mar;15(Supplement):S163-S166

Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

A 29-year-old hypertensive male with von Hippel-Lindau (VHL) syndrome came to the Endocrinology department for evaluation. Contrast-enhanced computed tomography of the abdomen revealed an adrenal mass, bilateral renal cell carcinoma, and multiple pancreatic cysts. The hormonal investigations for adrenal mass were normal. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_127_18DOI Listing
March 2019
2 Reads

Effect of a notch at the distal end of a microcatheter on vein deformation in segmental adrenal venous sampling: a preliminary study using computational fluid dynamics.

Med Biol Eng Comput 2019 Mar 18. Epub 2019 Mar 18.

Department of Diagnostic Radiology, Tohoku University Graduate school of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi-ken, 9800811, Japan.

This study aimed to evaluate the effect of a notch at the distal end of a microcatheter on vein deformation in segmental adrenal venous sampling. A three-dimensional fluid-structure interaction simulation was performed using commercial finite element software. A computational model of a vein with a catheter inserted into it was constructed. Read More

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http://dx.doi.org/10.1007/s11517-019-01968-1DOI Listing
March 2019
2 Reads

PTH Modulation by Aldosterone and Angiotensin II is Blunted in Hyperaldosteronism and Rescued by Adrenalectomy.

J Clin Endocrinol Metab 2019 Mar 13. Epub 2019 Mar 13.

Hypertension Unit, Department of Medicine -DIMED, University of Medicine of Padova, Padova, Italy.

Context: Accumulating evidences suggest a link between adrenocortical zona glomerulosa and parathyroid gland through mechanisms that remain unexplored.

Objectives: To test the hypothesis that in vivo Angiotensin (Ang) II blockade affects parathyroid hormone (PTH) secretion in hypertensive patients and that aldosterone and Ang II directly stimulate PTH secretion ex vivo.

Design And Setting: We investigated the changes of serum PTH levels induced by oral captopril (50 mg) administration in patients with primary essential hypertension (EH) and with primary aldosteronism (PA) due to bilateral adrenal hyperplasia (BAH) or to aldosterone-producing adenoma (APA), the latter before and after adrenalectomy. Read More

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
Publisher Site
http://dx.doi.org/10.1210/jc.2019-00143DOI Listing
March 2019
12 Reads

A case of acromegaly caused by Rathke's cleft cyst mimicking a plurihormonal pituitary adenoma.

World Neurosurg 2019 Mar 9. Epub 2019 Mar 9.

Department of Neurosurgery, Fukuoka University Chikushi Hospital, Chikushino-city, Japan.

Background: Acromegaly caused by Rathke's cleft cyst (RCC) mimicking a plurihormonal pituitary adenoma (PA) is rare.

Case Description: We report a 71-year-old woman who presented with hyperhidrosis in 2013. Magnetic resonance imaging (MRI) performed in April 2018 revealed that the patient had a pituitary tumor, and she was referred to our hospital. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.163DOI Listing
March 2019
2 Reads

The Utrecht Score: A novel histopathological scoring system to assess the prognosis of dogs with cortisol-secreting adrenocortical tumours.

Vet Comp Oncol 2019 Mar 12. Epub 2019 Mar 12.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.

A cortisol-secreting adrenocortical tumour (ACT) is the cause of naturally occurring canine hypercortisolism in approximately 15% to 20% of cases. The differentiation between an adrenocortical adenoma and carcinoma is usually based on histopathology. However, histopathological parameters have never been linked to the dogs' survival. Read More

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http://dx.doi.org/10.1111/vco.12474DOI Listing
March 2019
3 Reads

Long-term outcome of primary bilateral macronodular adrenocortical hyperplasia after unilateral adrenalectomy.

J Clin Endocrinol Metab 2019 Mar 7. Epub 2019 Mar 7.

Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, Germany.

Context: Unilateral adrenalectomy has been proposed in selected patients with primary bilateral macronodular adrenocortical hyperplasia (PBMAH), but its long-term outcome is unclear.

Objective: The aim of this study was to analyze long-term clinical and biochemical outcome of unilateral adrenalectomy versus bilateral adrenalectomy in patients with PBMAH in comparison to outcome of cortisol-producing adenoma (CPA) treated by unilateral adrenalectomy.

Design: Retrospective observational study in three German and one Italian academic tertiary care center. Read More

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
Publisher Site
http://dx.doi.org/10.1210/jc.2018-02204DOI Listing
March 2019
8 Reads

Minichromosome Maintenance Proteins MCM-3, MCM-5, MCM-7, and Ki-67 as Proliferative Markers in Adrenocortical Tumors.

Anticancer Res 2019 Mar;39(3):1151-1159

Department of General, Minimally Invasive and Endocrine Surgery, Wroclaw Medical University, Wroclaw, Poland.

Background/aim: Morphological features, combined with Ki-67 proliferative index, remain the standard for discriminating benign and malignant adrenocortical tumors. The aim of this study was to evaluate the role of minichromosome maintenance proteins MCM-3, MCM-5, MCM-7, and Ki-67 as proliferative markers in adrenocortical tumors.

Materials And Methods: Specimens of 81 adrenocortical adenomas and 3 adrenocortical carcinomas were stained with antibodies against MCM-3, 5, 7 and Ki-67. Read More

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http://dx.doi.org/10.21873/anticanres.13224DOI Listing
March 2019
2 Reads

Multiple endocrine neoplasia type 2A syndrome (MEN2A) and usefulness of 68Ga-DOTATATE PET/CT in this syndrome.

Ann Ital Chir 2019 Mar 4;8. Epub 2019 Mar 4.

Aim: The aim of this study was to evaluate a new imaging method 68Ga-DOTATATE PET/CT as an alternative method to diagnose evidence of neuroendocrine tumors or their metastasis (if any) in patient with MEN 2A.

Methods: Three patients( 2F, 1M; age 28,46 and 50 years) with MEN 2A syndrome who underwent 68Ga-DOTATATE PET/CT scan were prospectively evaluated. PET/CT images were analyzed with measurement of maximum standardized uptake value (SUVmax). Read More

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March 2019
5 Reads
0.683 Impact Factor

Clinical utility of routine postoperative morning cortisol monitoring in detecting new hypothalamic-pituitary-adrenal axis insufficiency following endoscopic transsphenoidal surgery for sellar lesions.

J Neurosurg 2019 Mar 1:1-5. Epub 2019 Mar 1.

1Department of Neurological Surgery and.

OBJECTIVEHypothalamic-pituitary-adrenal (HPA) axis dysfunction is a well-documented complication of transsphenoidal craniotomy (TSC) for sellar lesions. The authors aimed to assess their multidisciplinary approach to the diagnosis and treatment of postoperative hypocortisolemia utilizing conservative screening methods.METHODSThe authors performed a retrospective review of 257 patients who underwent TSC for pituitary adenoma (PA) or Rathke cleft cyst (RCC) at the University of Southern California between 2012 and 2017. Read More

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http://dx.doi.org/10.3171/2018.11.JNS182521DOI Listing
March 2019
4 Reads

A novel clinical nomogram to predict bilateral hyperaldosteronism in Chinese patients with primary aldosteronism.

Clin Endocrinol (Oxf) 2019 Feb 28. Epub 2019 Feb 28.

Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Context: Adrenal venous sampling (AVS) is recommended as the gold standard for subtype classification in primary aldosteronism (PA); however, this approach has limited availability.

Objective: We aimed to develop a novel clinical nomogram to predict PA subtype based on routine variables, thereby reducing the number of candidates for AVS.

Patients And Method: Patients were randomly divided into a training set (n = 185) and a validation set (n = 79). Read More

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http://dx.doi.org/10.1111/cen.13962DOI Listing
February 2019
8 Reads

Expression profiles analysis identifies the values of carcinogenesis and the prognostic prediction of three genes in adrenocortical carcinoma.

Oncol Rep 2019 Apr 19;41(4):2440-2452. Epub 2019 Feb 19.

Department of Urology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.

Adrenocortical carcinoma (ACC) is a rare disease associated with a poor prognosis. Furthermore, the underlying molecular mechanism of carcinogenesis is poorly understood, and prognostic prediction of ACC has low accuracy. In the present study, a bioinformatics approach was used to investigate the molecular mechanisms and prognosis of ACC. Read More

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http://dx.doi.org/10.3892/or.2019.7021DOI Listing
April 2019
2 Reads

Giant adrenal adenoma with hemorrhagic cystic degeneration.

Cir Esp 2019 Feb 15. Epub 2019 Feb 15.

Servicio de Cirugía General y del Aparato Digestivo, Hospital Clínico Universitario de Valladolid, Valladolid, España.

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http://dx.doi.org/10.1016/j.ciresp.2019.01.003DOI Listing
February 2019
2 Reads

Small Cell Lung Cancer with Pituitary Metastasis Presenting as Secondary Adrenal Insufficiency: A Case Report and Literature Review.

Am J Case Rep 2019 Feb 17;20:207-211. Epub 2019 Feb 17.

Department of Endocrinology, University of California San Francisco, San Francisco, CA, USA.

BACKGROUND Pituitary gland metastasis is rarely the initial presentation of metastatic cancer. Most cases of pituitary gland metastasis are asymptomatic with diabetes insipidus being the most common symptomatic presentation. It can rarely present with symptoms of hormone underproduction such as secondary adrenal insufficiency. Read More

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http://dx.doi.org/10.12659/AJCR.913388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388645PMC
February 2019
2 Reads

Acromegaly associated with GIST, non-small cell lung cancer, clear cell renal cancer, myeloma multiplex, medulla oblongata tumor, adrenal adenoma and follicular thyroid nodules.

Endokrynol Pol 2019 Feb 11. Epub 2019 Feb 11.

Dept. of Endocrinology, Diabetes and Isotope Therapy, Medical University Wroclaw, Pasteura 4, 50-367 Wrocłąw, Poland.

Background: Acromegaly is associated with increased growth hormone (GH) and insulin-like growth factor-I (IGF-I) secretion which may support tumor development and growth.

Case Presentation: A 68-year old woman was diagnosed with acromegaly due to typical clinical and hormonal characteristics. While a contrast-enhanced MRI at diagnosis did not reveal a pituitary adenoma, a 5 mm lesion was identified on repeat scanning 13 months later. Read More

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http://dx.doi.org/10.5603/EP.a2019.0005DOI Listing
February 2019
7 Reads

Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks.

Hypertension 2019 Apr;73(4):885-892

From the Department of Molecular and Integrative Physiology (K.N., W.E.R.), University of Michigan, Ann Arbor.

Somatic mutations have been identified in aldosterone-producing adenomas (APAs) in genes that include KCNJ5, ATP1A1, ATP2B3, and CACNA1D. Based on independent studies, there appears to be racial differences in the prevalence of somatic KCNJ5 mutations, particularly between East Asians and Europeans. Despite the high cardiovascular disease mortality of blacks, there have been no studies focusing on somatic mutations in APAs in this population. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416065PMC
April 2019
4 Reads

Exacerbation of Cushing's syndrome during pregnancy: stimulation of a cortisol-secreting adrenocortical adenoma by ACTH originating from the foeto-placental unit.

Endocrinol Diabetes Metab Case Rep 2019 Feb 7;2019. Epub 2019 Feb 7.

A 29-year-old G4A3 woman presented at 25 weeks of pregnancy with progressive signs of Cushing's syndrome (CS), gestational diabetes requiring insulin and hypertension. A 3.4 × 3. Read More

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http://dx.doi.org/10.1530/EDM-18-0115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373782PMC
February 2019
4 Reads

Arterial thrombosis as primary presentation of endogenous Cushing's syndrome.

BMJ Case Rep 2019 Feb 6;12(2). Epub 2019 Feb 6.

Department of Internal Medicine, Christian Medical College, Vellore, Tamil Nadu, India.

Cushing's syndrome is known to present with a characteristic set of clinical manifestations and complications, well described in literature. However, hypercoagulability remains an under recognised entity in Cushing's syndrome. A 31-year-old woman from Southern India presented with history of fever, left upper quadrant pain and progressive breathing difficulty for 3 weeks. Read More

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http://dx.doi.org/10.1136/bcr-2018-227491DOI Listing
February 2019
30 Reads

A Case of Primary Aldosteronism Due to A Primary Adrenal Adenoma Diagnosed by Segmental Adrenal Venous Sampling (S-AVS) Using a Modified Catheter System and Lateral Cine Angiography.

Am J Case Rep 2019 Feb 2;20:139-145. Epub 2019 Feb 2.

Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.

BACKGROUND Before partial adrenalectomy for primary aldosteronism due to a primary adrenal adenoma, the aldosterone-producing tumor can be localized by segmental adrenal vein sampling (S-AVS). Cardiologists, who regularly perform percutaneous coronary intervention (PCI), or coronary angioplasty with stent, may not be familiar with the technique of S-AVS. A case of the use of S-AVS is reported in a patient who presented with primary aldosteronism and a right adrenal adenoma. Read More

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http://dx.doi.org/10.12659/AJCR.913172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368131PMC
February 2019
1 Read

[Two case reports on resistant hypertension].

Internist (Berl) 2019 Feb 1. Epub 2019 Feb 1.

Klinik für Nieren- und Hochdruckerkrankungen, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Primary aldosteronism (PA) is a frequent cause of resistant hypertension. The clinical presentation is heterogeneous, but a suppressed or low normal renin (especially with ACE inhibitors or sartans) should raise suspicion for primary aldosteronism, even when aldosterone levels are in the normal range. Diagnosis of unilateral hormone production from an adrenal adenoma (Conn syndrome), which is curable by surgery, requires adrenal vein sampling, which should be performed in experienced centers. Read More

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http://dx.doi.org/10.1007/s00108-019-0563-1DOI Listing
February 2019
3 Reads

Incidental retroperitoneal oncocytoma (Ectopic oncocytic adrenocortical adenoma): Case report and review of the literature.

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):132-135

Department of Radiology, Karadeniz Technical University, Trabzon, Turkey.

Ectopic adrenocortical tissue may be present in many anatomical localizations. Hyperplasia, adenoma or carcinoma can occasionally develop from the ectopic adrenal tissue. Therefore, it should be surgically excised when it is detected. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_58_18DOI Listing
February 2019
2 Reads

Diagnostic value of adrenal iodine-131 6-beta-iodomethyl-19-norcholesterol scintigraphy for primary aldosteronism: a retrospective study at a medical center in North Taiwan.

Nucl Med Commun 2019 Jan 28. Epub 2019 Jan 28.

Department of Internal Medicine, Division of Endocrinology and Metabolism, College of Medicine.

Background: Primary aldosteronism (PA) is a common cause of secondary hypertension. Among the many leading causes of PA, the two most frequent are, bilateral adrenal hyperplasia (BAH) and aldosterone-producing adenomas (APA). Since a solitary APA may be cured surgically, but BAH needs lifelong pharmacologic therapy, confirmation is mandatory before surgery. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000987DOI Listing
January 2019
5 Reads

[A Case of Laparoscopic Low Anterior Resection and Adrenalectomy for Rectal Cancer and Adrenal Tumor].

Gan To Kagaku Ryoho 2018 Dec;45(13):2405-2407

Dept. of Surgery, Aomori Prefectural Central Hospital.

A 70-year-old woman had consulted a doctor at a former clinic because of bloody stool and colonoscopy revealed a type 2 tumor of the rectum. She was referred to our hospital for further examinations and treatment. Preoperative blood examination showed an elevated HbA1c level of 10. Read More

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December 2018
1 Read

Imaging features of adrenal masses.

Insights Imaging 2019 Jan 25;10(1). Epub 2019 Jan 25.

Dipartimento di Biomedicina, Neuroscienze e Diagnostica Avanzata, Università degli studi di Palermo, Via del Vespro 127, 90127, Palermo, Italy.

The widespread use of imaging examinations has increased the detection of incidental adrenal lesions, which are mostly benign and non-functioning adenomas. The differentiation of a benign from a malignant adrenal mass can be crucial especially in oncology patients since it would greatly affect treatment and prognosis. In this setting, imaging plays a key role in the detection and characterization of adrenal lesions, with several imaging tools which can be employed by radiologists. Read More

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http://dx.doi.org/10.1186/s13244-019-0688-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349247PMC
January 2019
3 Reads

Aldosterone-Producing Adenomas.

Vitam Horm 2019 8;109:407-431. Epub 2019 Jan 8.

Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Aldosterone-producing adenomas (APA) are more common than initially anticipated. APA cause primary aldosteronism (PA), which affect 3-10% of the hypertensive population. Research during recent years has led to an increased knowledge of the background dysregulation of the increased aldosterone release, where mutation in the gene encoding the potassium channel GIRK4-KCNJ5-is the most common. Read More

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http://dx.doi.org/10.1016/bs.vh.2018.10.007DOI Listing
January 2019
2 Reads

Primary Aldosteronism: Present and Future.

Authors:
John W Funder

Vitam Horm 2019 23;109:285-302. Epub 2018 Dec 23.

Hudson Institute of Medical Research, Clayton, VIC, Australia; Monash University, Clayton, VIC, Australia. Electronic address:

Primary aldosteronism (PA), currently recognized to be 5-10% of hypertension, has a cardiovascular risk profile double that in age-, sex-, and blood pressure-matched essential hypertensives. Screening for PA is by determining the plasma aldosterone to renin ratio (ARR), followed by one of half a dozen confirmatory/exclusion tests. Unilateral hyperaldosteronism normally reflects an aldosterone producing adenoma; bilateral disease is the more common form, and termed idiopathic hyperaldosteronism (IHA). Read More

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http://dx.doi.org/10.1016/bs.vh.2018.10.006DOI Listing
December 2018
2 Reads

Changes in glucose metabolism based on 75-g oral glucose tolerance tests before and after surgery for adrenal Cushing's syndrome.

Endocr J 2019 Mar 22;66(3):207-214. Epub 2019 Jan 22.

Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Yokohama 222-0036, Japan.

Adrenal Cushing's syndrome (CS) is caused by cortisol-producing adrenal adenoma and is frequently accompanied by glucose metabolism disorders, which are characterized by increased insulin resistance and insufficient β-cell compensation. However, considering the rarity of CS, few studies have assessed whether the glucose metabolism disorders could be ameliorated by surgical treatment. In this case series, we evaluated glucose metabolism before and after surgery in 11 patients (10 women and 1 man) who underwent unilateral adrenalectomy for overt adrenal CS between 2005 and 2016. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0445DOI Listing
March 2019
3 Reads

A rare case of pure testosterone-secreting adrenal adenoma in a postmenopausal elderly woman.

BMC Endocr Disord 2019 Jan 23;19(1):14. Epub 2019 Jan 23.

Department of Endocrinology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, 310003, Hangzhou, China.

Background: Hyperandrogenemia is more common in puberty and reproductive age, but relatively rare in postmenopausal women. Postmenopausal virilization may result from androgen-producing tumors. Androgen-secreting adrenal tumors are rare in clinical practice and are diagnosed as adrenocortical carcinoma, most of which can co-secrete androgen and cortisol. Read More

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http://dx.doi.org/10.1186/s12902-019-0342-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343319PMC
January 2019
2 Reads

A case of autonomous cortisol secretion in a patient with subclinical Cushing's syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone.

BMC Endocr Disord 2019 Jan 22;19(1):13. Epub 2019 Jan 22.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Increased urinary free cortisol in response to the oral administration of dexamethasone is a paradoxical reaction mainly reported in patients with primary pigmented nodular adrenocortical disease. Here, we describe the first case of subclinical Cushing's syndrome represented by autonomous cortisol secretion and paradoxical response to oral dexamethasone administration, harboring an activating mutation in the α subunit of the stimulatory G protein (GNAS).

Case Presentation: A 65-year-old woman was diagnosed with subclinical Cushing's syndrome during an evaluation for bilateral adrenal masses. Read More

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http://dx.doi.org/10.1186/s12902-019-0345-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343241PMC
January 2019
2 Reads

Impact of immunohistochemistry on the diagnosis and management of primary aldosteronism: An important tool for improved patient follow-up.

Scand J Surg 2019 Jan 17:1457496918822622. Epub 2019 Jan 17.

4 Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

Background And Aims:: Primary aldosteronism is a common cause of secondary hypertension. Primary aldosteronism is caused by an aldosterone-producing adenoma or bilateral hyperplasia that in some cases is asymmetrical with one adrenal dominating aldosterone secretion. Most patients with aldosterone-producing adenoma are biochemically cured by unilateral adrenalectomy, but patients with bilateral hyperplasia have a significant risk of residual or recurrent disease. Read More

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http://dx.doi.org/10.1177/1457496918822622DOI Listing
January 2019
16 Reads

Classification of microadenomas in patients with primary aldosteronism by steroid profiling.

J Steroid Biochem Mol Biol 2019 Jan 14. Epub 2019 Jan 14.

Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, Munich, Germany; Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Turin, Italy. Electronic address:

In primary aldosteronism (PA) the differentiation of unilateral aldosterone-producing adenomas (APA) from bilateral adrenal hyperplasia (BAH) is usually performed by adrenal venous sampling (AVS) and/or computed tomography (CT). CT alone often lacks the sensitivity to identify micro-APAs. Our objectives were to establish if steroid profiling could be useful for the identification of patients with micro-APAs and for the development of an online tool to differentiate micro-APAs, macro-APAs and BAH. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09600760183047
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http://dx.doi.org/10.1016/j.jsbmb.2019.01.008DOI Listing
January 2019
11 Reads

Pituitary adenomas in patients with multiple endocrine neoplasia type 1: a single-center experience in China.

Pituitary 2019 Apr;22(2):113-123

Department of Endocrinology, Peking Union Medical College Hospital, Beijing, 100730, China.

Purpose: To explore the clinical characteristics of pituitary adenomas in patients with MEN1 and to summarize treatment strategies for MEN1 in a Chinese population.

Methods: We retrospectively analyzed 54 MEN1 patients with pituitary adenomas diagnosed at Peking Union Medical College Hospital from March 2003 to January 2017. Clinical data, laboratory testing results, treatments of involved glands and treatment responses were collected and analyzed. Read More

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http://link.springer.com/10.1007/s11102-019-00939-x
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http://dx.doi.org/10.1007/s11102-019-00939-xDOI Listing
April 2019
23 Reads
2.222 Impact Factor

Recovery of Adrenal Function after Pituitary Surgery in Patients with Cushing Disease: Persistent Remission or Recurrence?

Neuroendocrinology 2019 Jan 13. Epub 2019 Jan 13.

Endocrinology Unit, Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda, Milan, Italy.

Background: Cushing disease (CD) represents the principal cause of endogenous hypercortisolism. The first-line therapy of CD is surgical removal of the ACTH-secreting pituitary adenoma, which is generally followed by adrenal insufficiency (AI).

Objective: To analyze the recovery of AI in patients with CD after pituitary surgery in relation with recurrence and persistent remission of CD. Read More

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http://dx.doi.org/10.1159/000496846DOI Listing
January 2019
12 Reads
4.373 Impact Factor

Efficient screening of patients with aldosterone-producing adenoma using the ACTH stimulation test.

Hypertens Res 2019 Jan 8. Epub 2019 Jan 8.

Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

Adrenal venous sampling (AVS) is the gold standard test for distinguishing between unilateral and bilateral primary aldosteronism (PA); however, AVS requires advanced and time consuming technique. The needs for AVS have been increasing due to the increased utilization of screening for PA. An efficient selection of unilateral PA, such as aldosterone-producing adenoma (APA), before AVS is useful to avoid undesirable AVS in bilateral PA, such as idiopathic hyperaldosteronism. Read More

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http://dx.doi.org/10.1038/s41440-018-0191-5DOI Listing
January 2019
3 Reads

Evaluation of diagnostic accuracy: multidetector CT image noise correction improves specificity of a Gaussian model-based algorithm used for characterization of incidental adrenal nodules.

Abdom Radiol (NY) 2019 Mar;44(3):1033-1043

Body Imaging Section, Department of Radiology, University of Washington, Box 358081, 825 Eastlake Ave E, G2-600, Seattle, WA, 98109, USA.

Objectives: To investigate whether the histogram analysis method of characterizing adrenal nodules as adenomas is affected by increased noise with modern CT technique, and if an extension that allows for noise correction will improve diagnostic performance.

Materials And Methods: This is a HIPAA-compliant, IRB-approved retrospective study performed on 58 total patients. The first group of 29 patients had 33 adrenal lesions that were pathology-proven non-adenomas. Read More

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http://dx.doi.org/10.1007/s00261-018-1871-yDOI Listing
March 2019
4 Reads

Stent-Assisted Coil Embolization for a Ruptured Posterior Communicating Artery Pseudoaneurysm After Endoscopic Transsphenoidal Surgery for Pituitary Adenoma.

World Neurosurg 2019 Mar 22;123:301-305. Epub 2018 Dec 22.

Department of Neurosurgery, Fukuoka University Chikushi Hospital, Chikushino-city, Japan.

Background: Intracranial pseudoaneurysm is a rare complication of endoscopic endonasal surgery. Herein, we describe 2-staged stent-assisted coil embolization for posterior communicating artery pseudoaneurysm after endoscopic endonasal surgery for pituitary adenoma.

Case Description: A 68-year-old man had a history of severe adult growth hormone secretion deficiency, requiring growth hormone replacement therapy; secondary adrenocortical hypofunction; hyperthyroidism; hypertension; constipation; glaucoma; and hyperuricemia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183287
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http://dx.doi.org/10.1016/j.wneu.2018.12.047DOI Listing
March 2019
10 Reads

Proteomic Landscape of Aldosterone-Producing Adenoma.

Hypertension 2019 Feb;73(2):469-480

From the Biozentrum, University of Basel, Switzerland (M.M.S., M.C., E.D., P.J., S.M., C.P., M.N.H.), University Hospital Basel, Switzerland.

Primary aldosteronism is a disease of excessive production of adrenal steroid hormones and the most common cause of endocrine hypertension. Primary aldosteronism results mainly from bilateral adrenal hyperplasia or unilateral aldosterone-producing adenoma (APA). Primary aldosteronism cause at the molecular level is incompletely understood and a targeted treatment preventing excessive adrenal steroid production is not available. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11733DOI Listing
February 2019
5 Reads

Rates of abnormal aldosterone/renin ratio in African-origin compared to European-origin patients: A retrospective study.

Clin Endocrinol (Oxf) 2019 Apr 25;90(4):528-533. Epub 2019 Jan 25.

Department of Endocrinology, The Adelaide and Meath Hospital, Incorporating the National Children's Hospital, Tallaght, Dublin, Ireland.

Introduction: The aldosterone/renin ratio is the initial screening test for primary hyperaldosteronism (PHA), but little data exists regarding ethnic variations in this.

Methods: Following clinical observation of a high prevalence of abnormal aldosterone/renin ratio (ARR) in patients of African-origin, we retrospectively reviewed all ARR measurements in a single centre over 10 years. Rates of hypokalaemia, intraventricular septal thickness (IVS, by echocardiography) and adrenal imaging were recorded when available. Read More

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http://dx.doi.org/10.1111/cen.13920DOI Listing
April 2019
7 Reads

Aldosterone and 18-Oxocortisol Coaccumulation in Aldosterone-Producing Lesions.

Hypertension 2018 Dec;72(6):1345-1354

From the Department of Biochemistry (Y.S., M.S., K.N.), Keio University School of Medicine, Tokyo, Japan.

Primary aldosteronism is a secondary hypertensive disease caused by autonomous aldosterone production that often caused by an aldosterone-producing adenoma (APA). Immunohistochemistry of aldosterone synthase (CYP11B2) shows the presence of aldosterone-producing cell clusters (APCCs) even in non-primary aldosteronism adult adrenal cortex. An APCC-like structure also exists as possible APCC-to-APA transitional lesions (a speculative designation) in primary aldosteronism adrenals. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11243DOI Listing
December 2018
2 Reads

[Cushing's syndrome during pregnancy : diagnostic and therapeutic difficulties].

Rev Med Liege 2018 Dec;73(12):603-609

Service d`Endocrinologie, CHU de Liège, Liège, Belgique.

Cushing's syndrome (CS), which is often associated with infertility, exceptionally occurs in pregnancy, and markedly increases maternal and fetal morbidity and mortality. Gestational CS may be challenging. Indeed, symptoms of hypercorticism may overlap with physiological hyperactivity of the hypothalamus-pituitary-adrenal axis in normal pregnancy. Read More

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December 2018
4 Reads

Familial hyperaldosteronism type III a novel case and review of literature.

Rev Endocr Metab Disord 2018 Dec 19. Epub 2018 Dec 19.

Department of Pediatrics, Hospital Lluís Alcanyís de Xàtiva, Ctra. Xàtiva a Silla km 2, 46800, Xàtiva, Valencia, Spain.

Less than 15% of hypertension cases in children are secondary to a primary hyperaldosteronism. This is idiopathic in 60% of the cases, secondary to a unilateral adenoma in 30% and 10% remaining by primary adrenal hyperplasia, familial hyperaldosteronism, ectopic aldosterone production or adrenocortical carcinoma.To date, four types of familial hyperaldosteronism (FH I to FH IV) have been reported. Read More

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http://link.springer.com/10.1007/s11154-018-9481-0
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http://dx.doi.org/10.1007/s11154-018-9481-0DOI Listing
December 2018
19 Reads