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    Mixed corticomedullary adrenal carcinoma - case report: Comparison in features, treatment and prognosis with the other two reported cases.
    Int J Surg Case Rep 2017 Jan 31;31:254-261. Epub 2017 Jan 31.
    Alberoni Hospital, Damascus University Faculty of Medicine, P.O. Box: 60527, Damascus, Syria. Electronic address:
    Introduction: Adrenal corticomedullary adenoma was reviewed in many cases in PubMed Library, While the coincidence corticomedullary adrenal carcinoma in the same gland was just described in two cases in the medical literature. Our case is the third to be reported and was treated with surgery and adjuvant chemotherapy and followed for two years.

    Presentation Of Case: A 50-year-old man suffered from a mass effect in the left abdominal side. Read More

    Recommendations For The Management Of Adrenal Incidentalomas: What is pertinent for Radiologists?
    Br J Radiol 2017 Feb 9:20160627. Epub 2017 Feb 9.
    1 Department of Imaging, St Bartholomew's Hospital, Barts Health NHS Trust, London UK EC1A 7BE.
    Adrenal incidentalomas are unsuspected, asymptomatic adrenal masses detected on imaging. Most are non-functioning benign adrenocortical adenomas, but can represent other benign lesions or lesions requiring therapeutic intervention including adrenocortical carcinoma, pheochromocytoma, hormone-producing adenoma or metastasis. This review summarises and highlights radiological recommendations within the recently issued guidelines for the management of adrenal incidentalomas from European Society of Endocrinology Clinical Practice in collaboration with European Network for Study of Adrenal Tumours. Read More

    [Tetraparesis revealing Conn adenoma in a pregnant woman].
    Pan Afr Med J 2016 27;25:24. Epub 2016 Sep 27.
    Service de Médecine Interne, Hôpital Militaire d'Instruction Mohammed V, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.
    We report the case of Conn adenoma revealed by tetraparesis in a 33-year old pregnant woman at the 16(th)week of amenorrhea. The patient had a blood pressure of 147/87 mmHg, which was considered high-normal, hypokalemia at 1.1 mmol/l. Read More

    Anatomical Variations of the Right Adrenal Vein: Concordance Between Multidetector Computed Tomography and Catheter Venography.
    Hypertension 2017 Mar 30;69(3):428-434. Epub 2017 Jan 30.
    From the Department of Diagnostic Radiology (K.O., H.O., Y.T., T.M., K.S., K.T.), Department of Urology (Y.A.), and Division of Nephrology, Endocrinology, and Vascular Medicine (R.M., F.S.), Tohoku University Hospital, Sendai, Japan.
    Adrenal venous sampling is the most reliable diagnostic procedure to determine surgical indications in primary aldosteronism. Because guidelines recommend multidetector computed tomography (CT) to evaluate the adrenal gland, some past reports used multidetector CT as a guide for adrenal venous sampling. However, the detailed anatomy of the right adrenal vein and its relationship with an accessory hepatic vein remains uncertain. Read More

    Management of Adrenal Masses.
    Indian J Surg Oncol 2017 Mar 17;8(1):67-73. Epub 2016 Dec 17.
    Department of Urology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Amrita lane elmakkara, Kochi, Kerala 682041 India.
    An adrenal mass can be either symptomatic or asymptomatic in the form of adrenal incidentalomas (AIs) in up to 8 % in autopsy and 4 % in imaging series. Once a diagnosis of adrenal mass is made, we need to differentiate whether it is functioning or nonfunctioning, benign, or malignant. In this article, we provide a literature review of the diagnostic workup including biochemical evaluation and imaging characteristics of the different pathologies. Read More

    Practical Approach to Adrenal Imaging.
    Radiol Clin North Am 2017 Mar 12;55(2):279-301. Epub 2016 Dec 12.
    Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street Unit 1473, Houston, TX 77030, USA.
    Various pathologies can affect the adrenal gland. Noninvasive cross-sectional imaging is used for evaluating adrenal masses. Accurate diagnosis of adrenal lesions is critical, especially in cancer patients; the presence of adrenal metastasis changes prognosis and treatment. Read More

    Assessment of the Aldosteronona resolution score as a predictive resolution score of hypertension after adrenalectomy for aldosteronoma in French patients.
    Langenbecks Arch Surg 2017 Jan 22. Epub 2017 Jan 22.
    Clinique de Chirurgie Digestive et Endocrinienne (CCDE), Institut des Maladies de l'Appareil Digestif (IMAD), CHU Hôtel-Dieu, 1 place Alexis Ricordeau, 44093, Nantes cedex 1, France.
    Purpose: Aldosteronoma Resolution Score (ARS) is a predictive score for cure of hypertension after adrenalectomy for hyperaldosteronism and has been validated in American patients. The aim of the study was to validate this score in a French population.

    Method: Data concerning patients operated from 2002 to 2015 in 7 French University Hospitals were retrospectively collected. Read More

    Hyperandrogenism in a postmenopausal woman: a rare case of ectopic adrenal cortical gland.
    Gynecol Endocrinol 2017 Jan 19:1-3. Epub 2017 Jan 19.
    a Department of Medical and Surgical Sciences and Translational Medicine and.
    Most frequent causes of androgenic manifestation are Cushing's syndrome, PCO, benign and malignant androgen-secreting non adrenal tumors and iatrogenic hirsutism. Hyperplasia or neoplasms of ectopic adrenocortical gland are rare. We report a case of a 63-year old female with hirsutism and alopecia. Read More

    Hypokalemic myopathy in primary aldosteronism: A case report.
    Exp Ther Med 2016 Dec 2;12(6):4064-4066. Epub 2016 Nov 2.
    Department of Nephrology, Lishui Hospital Affiliated to Zhejiang University, Lishui, Zhejiang 323000, P.R. China.
    Primary aldosteronism (PA) is a rare disorder. The majority of patients with PA present with typical features and are easily diagnosed. This disorder is usually diagnosed with hypokalemia, hypertension or an adrenal mass. Read More

    PURE ANDROGEN-PRODUCING ADRENAL TUMOR: CLINICAL FEATURES AND PATHOGENESIS.
    Endocr Pract 2017 Jan 17. Epub 2017 Jan 17.
    From: 1Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences, Beijing 100730, China.
    Objective: Pure androgen-secreting adrenal tumors (PASATs) are extremely rare, most reports involving only a single case. This study examined 9 cases of PASAT, with an attempt to characterize its clinical features and to explore their possible pathogenesis.

    Methods: Clinical data of 9 patients with PASAT were retrospectively reviewed. Read More

    Immunohistochemical Approach for the Diagnosis of a Liver Mass on Small Biopsy Specimens.
    Hum Pathol 2017 Jan 10. Epub 2017 Jan 10.
    Department of Pathology, University of California at San Francisco, San Francisco, CA 94143.
    Well-differentiated hepatocellular carcinoma (HCC) shares overlapping histological features with benign hepatocellular lesions, including hepatocellular adenoma (HCA) and focal nodular hyperplasia (FNH) in non-cirrhotic liver, and with high-grade dysplastic nodule (HGDN) in cirrhotic liver. Several metastatic tumors, such as neuroendocrine tumor, renal cell carcinoma, adrenocortical carcinoma, melanoma, and epithelioid angiomyolipoma, can be indistinguishable from HCC on histologic grounds. Since this distinction has important therapeutic implications, judicious use of immunohistochemical markers plays an important role in establishing an accurate diagnosis, especially when limited material of tumor is available on cell block or a small core biopsy. Read More

    Long-term Consequences of Congenital Adrenal Hyperplasia due to Classic 21-hydroxylase Deficiency in Adolescents and Adults.
    Exp Clin Endocrinol Diabetes 2017 Jan 10. Epub 2017 Jan 10.
    Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
    Background The management of congenital adrenal hyperplasia (CAH) from pediatric to adulthood is challenging to achieve optimal growth and puberty. This study characterizes the clinical outcomes of 21-hydroxylase deficiency. Methods 53 CAH patients were included (33 females, 15 and 18 patients with the salt-wasting [SW] and simple-virilizing [SV] forms; and 20 males, 16 and 4 patients with the SW and SV forms). Read More

    Contemporary imaging of incidentally discovered adrenal masses.
    Biomed Pharmacother 2017 Mar 4;87:256-262. Epub 2017 Jan 4.
    Department of Radiology, University of Michigan Hospital, Ann Arbor, MI 48109, USA; Department of Nuclear Medicine, Department of Veterans Affairs Health System, Ann Arbor, MI 48105, USA.
    Adrenal lesions are routinely encountered incidentally in clinical practice. Although most of these lesions are benign, malignancy needs to be excluded. Therefore, the initial clinical workup is to exclude aggressive characteristics suggesting malignancy and to identify characteristics predictive of the most common benign lesion, an adrenal adenoma. Read More

    [Clinical features and outcomes of congenital adrenal hyperplasia with adenomatoid adrenal gland].
    Zhonghua Yi Xue Za Zhi 2016 Dec;96(48):3879-3884
    Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
    Objective: To analyze the clinical features and outcomes of congenital adrenal hyperplasia (CAH) with adenomatoid adrenal gland. Methods: Nineteen patients clinically confirmed as CAH with adenomatoid adrenal gland, from 2008 to 2015 in Deparment of Endocrinology of Chinese PLA General Hospital, were retrospectively analyzed, and the outcomes of the treatment were followed up. Results: Seventy-six patients were clinically confirmed as CAH, from 2008 to 2015 in PLA hospital. Read More

    Adrenal Collision Tumor: Coexistence of Pigmented Adrenal Cortical Oncocytoma and Ganglioneuroma.
    Case Rep Surg 2016 8;2016:5790645. Epub 2016 Dec 8.
    Department of Pathology, Korea University School of Medicine, Seoul, Republic of Korea.
    Background. Adrenal collision tumors (ACTs), in which distinct tumors coexist without intermingling in the same adrenal gland, are rare and their actual prevalence is unknown. ACTs commonly consist of adrenal cortical adenoma, pheochromocytoma, or metastatic malignant tumor. Read More

    Proton-density fat fraction measurement: A viable quantitative biomarker for differentiating adrenal adenomas from nonadenomas.
    Eur J Radiol 2017 Jan 5;86:112-118. Epub 2016 Nov 5.
    Russell H. Morgan Department of Radiology and Radiological Science, the Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
    Purpose: This study aims to compare the accuracy of proton-density fat fraction (PDFF) measurements with chemical shift magnetic resonance imaging (CSI) for quantifying the fat content of adrenal nodules and for differentiating adenomas from nonadenomas.

    Materials And Methods: Oil-saline phantom measurements was performed to compare the correlation between PDFF and CSI in detecting and quantifying fat content. 43 consecutive patients who had known adrenal nodules were imaged on a 3. Read More

    Concomitant alterations of metabolic parameters, cardiovascular risk factors and altered cortisol secretion in patients with adrenal incidentalomas during prolonged follow-up.
    Clin Endocrinol (Oxf) 2016 Dec 19. Epub 2016 Dec 19.
    Department of Pathophysiology, Laikon Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
    Objective: Adrenal incidentalomas (AI) are associated with metabolic and hormonal abnormalities, most commonly autonomous cortisol secretion (ACS). Data regarding alterations of insulin resistance (IR) and ACS after prolonged follow-up are limited. We investigated the evolution of IR, cortisol secretion and ACS development in patients with AI during prolonged follow-up. Read More

    Clinical characteristics of adrenal tumors in children: a retrospective review of a 15-year single-center experience.
    Int Urol Nephrol 2016 Dec 17. Epub 2016 Dec 17.
    Department of Pediatric Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
    Objective: Adrenal tumors are rare in children. The aim of this study is to review and analyze clinical data on the diagnosis and management of adrenal tumors in children.

    Methods: Between 2001 and 2015, 48 pediatric patients (<14 years old) admitted to our institute with adrenal tumors were reviewed. Read More

    Laparoscopic Treatment of Adrenal Tumors: A Single-Center Experience with 58 Patients.
    Surg Res Pract 2016 16;2016:9574391. Epub 2016 Nov 16.
    Department of General Surgery, Istanbul Education and Research Hospital, Istanbul, Turkey.
    Background. The aim of this study is to discuss the laparoscopic approach and assess the immunohistochemical expression profiles of synaptophysin, Ki-67, and inhibin and patient outcomes in adrenal masses through a series of cases treated at our institution. Method. Read More

    Is Laparoendoscopic Single-Site Adrenalectomy a Feasible Alternative in Treating Aldosterone-Producing Adenoma?
    Biomed Res Int 2016 16;2016:6894381. Epub 2016 Nov 16.
    Department of Surgery, Taipei Tzuchi Hospital, The Buddhist Tzu Chi Medical Foundation, Taipei, Taiwan; Department of Urology, Tzu Chi University, Medical College, Hualien, Taiwan.
    Objective. To compare laparoendoscopic single-site (LESS) and conventional multiport adrenalectomy in patients with aldosterone-producing adenoma (APA). Material and Methods. Read More

    Cushing's disease: a multidisciplinary overview of the clinical features, diagnosis, and treatment.
    J Med Life 2016 Jan-Mar;9(1):12-18
    "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; C.I. Parhon National Institute of Endocrinology, Bucharest, Romania.
    Cushing's disease is considered a rare condition characterized by the hypersecretion of the adrenocorticotropic hormone (ACTH) due to a pituitary adenoma that ultimately causes endogenous hypercortisolism by stimulating the adrenal glands. The clinical signs suggesting Cushing's disease, such as obesity, moon face, hirsutism, and facial plethora are already present on presentation. Endogenous hypercortisolism is associated with an increased risk of cardiovascular and metabolic manifestations, as well as respiratory disorders, psychiatric complications, osteoporosis and infections, leading to high rates of morbidity and mortality. Read More

    Unmasked chronic renal function deterioration after unilateral adrenalectomy in patients with primary aldosteronism.
    Kidney Res Clin Pract 2016 Dec 20;35(4):255-258. Epub 2016 May 20.
    Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
    We report 2 cases of chronic estimated glomerular filtration rate (eGFR) decline after unilateral adrenalectomy due to primary aldosteronism. The patients were diagnosed with unilateral adrenal cortical adenoma releasing aldosterone. Two patients were examined for hypertension and hypokalemia. Read More

    Carney complex: A familial lentiginosis predisposing to a variety of tumors.
    Rev Endocr Metab Disord 2016 Sep;17(3):367-371
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room East 1330, CRC, 10 Center Dr. MSC1862, Bethesda, MD, 20892-1862, USA.
    Carney complex is a familial lentiginosis syndrome; these disorders cover a wide phenotypic spectrum ranging from a benign inherited predisposition to develop cutaneous spots not associated with systemic disease to associations with several syndromes. Carney complex is caused by PRKAR1A mutations and perturbations of the cyclic AMP-dependent protein kinase (PKA) signaling pathway. In addition to the cutaneous findings, the main tumors associated with Carney complex are endocrine: 1) primary pigmented nodular adrenocortical disease, a bilateral adrenal hyperplasia leading to Cushing syndrome; 2) growth-hormone secreting pituitary adenoma or pituitary somatotropic hyperplasia leading to acromegaly; 3) thyroid and gonadal tumors, including a predisposition to thyroid cancer. Read More

    Cell signaling pathways in the adrenal cortex: Links to stem/progenitor biology and neoplasia.
    Mol Cell Endocrinol 2016 Dec 8. Epub 2016 Dec 8.
    Cancer Biology Graduate Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI 48109, USA; Endocrine Oncology Program, Comprehensive Cancer Center, University of Michigan Health System, 109 Zina Pitcher Place, 1528 BSRB, Ann Arbor, MI 48109, USA. Electronic address:
    The adrenal cortex is a dynamic tissue responsible for the synthesis of steroid hormones, including mineralocorticoids, glucocorticoids, and androgens in humans. Advances have been made in understanding the role of adrenocortical stem/progenitor cell populations in cortex homeostasis and self-renewal. Recently, large molecular profiling studies of adrenocortical carcinoma (ACC) have given insights into proteins and signaling pathways involved in normal tissue homeostasis that become dysregulated in cancer. Read More

    Ultrasonographic features of adrenal gland lesions in dogs can aid in diagnosis.
    BMC Vet Res 2016 Nov 28;12(1):267. Epub 2016 Nov 28.
    Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2-5, 10095, Grugliasco, TO, Italy.
    Background: Ultrasonography to visualize adrenal gland lesions and evaluate incidentally discovered adrenal masses in dogs has become more reliable with advances in imaging techniques. However, correlations between sonographic and histopathological changes have been elusive. The goal of our study was to investigate which ultrasound features of adrenal gland abnormalities could aid in discriminating between benign and malignant lesions. Read More

    Currently used and investigational drugs for Cushing´s disease.
    Expert Opin Investig Drugs 2017 Jan 8;26(1):75-84. Epub 2016 Dec 8.
    a Clinical Neuroendocrinology , Max Planck Institute of Psychiatry , Munich , Germany.
    Introduction: Cushing's disease (CD) is caused by a corticotroph adenoma of the pituitary gland that secretes excess adrenocorticotropic hormone (ACTH) causing increased morbidity and mortality. Surgery is the treatment of choice, but is not always successful. Alternatives include radiotherapy, adrenal surgery, and pharmaceutical therapy. Read More

    Primary aldosteronism: from case detection to histopathology with up to 6 years of follow-up.
    J Clin Hypertens (Greenwich) 2016 Nov 23. Epub 2016 Nov 23.
    Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
    The authors aimed to investigate the clinical characteristics, accuracy of diagnostic tests, and long-term outcomes after interventions in patients diagnosed with primary aldosteronism (PA) in Iceland throughout 5 years. A retrospective chart review was performed for all patients diagnosed with PA during the years 2007-2011 at Landspitali Hospital in Iceland, a referral center for the whole country. Workup after detection included salt loading test, positional test, computed tomography, and adrenal vein sampling. Read More

    A single-centre experience of the implementation of adrenal vein sampling procedure: the impact on the diagnostic work-up in primary aldosteronism.
    Kardiol Pol 2017 23;75(1):28-34. Epub 2016 Nov 23.
    Department of Invasive Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland.
    Background: Primary aldosteronism is one of the most common causes of secondary hypertension. Adrenal vein sampling (AVS) remains a "gold standard" procedure in differentiation between unilateral (adenoma) and bilateral (hyperplasia) disease.

    Aim: The aim of this study was to present our single-centre experience in establishing and implementating the AVS procedure. Read More

    Cushing Syndrome in Carney Complex: Clinical, Pathologic, and Molecular Genetic Findings in the 17 Affected Mayo Clinic Patients.
    Am J Surg Pathol 2017 Feb;41(2):171-181
    *Department of Internal Medicine †Division of Endocrinology, Diabetes, Metabolism and Nutrition §Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN ‡Section on Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
    Carney complex (CNC) is a rare dominantly inherited multiorgan tumoral disorder that includes Cushing syndrome (CS). To establish the Mayo Clinic experience with the CS component, including its clinical, laboratory, and pathologic findings, we performed a retrospective search of the patient and pathologic databases of Mayo Clinic in Rochester, MN, for patients with CNC and clinical or laboratory findings of CS. Thirty-seven patients with CNC were identified. Read More

    Suppression of cytochrome P450 4B1: An early event in adrenocortical tumorigenesis.
    Surgery 2017 Jan 16;161(1):257-263. Epub 2016 Nov 16.
    Department of Surgery and Yale Endocrine Neoplasia Laboratory, Yale School of Medicine, New Haven, CT. Electronic address:
    Background: Adrenocortical carcinoma is a rare neoplasm with a poor prognosis. Conversely, adrenocortical adenomas are common and benign. Despite their shared histologic origin, little evidence exists to suggest that adrenocortical adenoma arises from adrenocortical carcinoma. Read More

    Of channels and pumps: different ways to boost the aldosterone?
    Acta Physiol (Oxf) 2016 Nov 15. Epub 2016 Nov 15.
    Medical Cell Biology, University of Regensburg, Regensburg, Germany.
    The mineralocorticoid aldosterone is a major factor controlling the salt and water balance and thereby also the arterial blood pressure. Accordingly, primary aldosteronism (PA) characterized by an inappropriately high aldosterone secretion is the most common form of secondary hypertension. The physiological stimulation of aldosterone synthesis in adrenocortical glomerulosa cells by angiotensin II and an increased plasma K(+) concentration depends on a membrane depolarization and an increase in the cytosolic Ca(2+) activity. Read More

    Expression of CYP11B2 in Aldosterone-Producing Adrenocortical Adenoma: Regulatory Mechanisms and Clinical Significance.
    Tohoku J Exp Med 2016 ;240(3):183-190
    Division of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University.
    Aldosterone-producing adrenocortical adenoma (APA) is responsible for the majority of cases clinically diagnosed as primary aldosteronism. Aldosterone synthase (CYP11B2) is one of the enzymes that play essential roles in aldosterone synthesis and is involved in the pathogenesis of APA. Recent studies have demonstrated that various factors and regulators influence the expression and function of CYP11B2 in APA. Read More

    Differentiation between adrenal adenomas and nonadenomas using dynamic contrast-enhanced computed tomography.
    Onco Targets Ther 2016 3;9:6809-6817. Epub 2016 Nov 3.
    Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai.
    This study was performed to evaluate the findings including the time density curve (TD curve), the relative percentage of enhancement washout (Washr) and the absolute percentage of enhancement washout (Washa) at dynamic contrast-enhanced computed tomography (DCE-CT) in 70 patients with 79 adrenal masses (including 44 adenomas and 35 nonadenomas) confirmed histopathologically and/or clinically. The results demonstrated that the TD curves of adrenal masses were classified into 5 types, and the type distribution of the TD curves was significantly different between adenomas and nonadenomas. Types A and C were characteristic of adenomas, whereas types B, D and E were features of nonadenomas. Read More

    Cardiac Dysfunction in Association with Increased Inflammatory Markers in Primary Aldosteronism.
    Endocrinol Metab (Seoul) 2016 Dec 3;31(4):567-576. Epub 2016 Nov 3.
    Department of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea.
    Background: Oxidative stress in primary aldosteronism (PA) is thought to worsen aldosterone-induced damage by activating proinflammatory processes. Therefore, we investigated whether inflammatory markers associated with oxidative stress is increased with negative impacts on heart function as evaluated by echocardiography in patients with PA.

    Methods: Thirty-two subjects (mean age, 50. Read More

    Prevalence of adrenal gland masses as incidental findings during abdominal computed tomography in dogs: 270 cases (2013-2014).
    J Am Vet Med Assoc 2016 Nov;249(10):1165-1169
    OBJECTIVE To determine the prevalence and clinical characteristics of incidental adrenal gland masses identified in dogs undergoing abdominal CT. DESIGN Retrospective case series. ANIMALS 270 client-owned dogs. Read More

    Multiple endocrine neoplasia similar to human subtype 2A in a dog: Medullary thyroid carcinoma, bilateral pheochromocytoma and parathyroid adenoma.
    Open Vet J 2016 15;6(3):165-171. Epub 2016 Oct 15.
    Alumna de Programa de Investigación. Fac. de Ciencias Veterinarias, UBA, Chorroarín 280, Ciudad Autónoma de Buenos Aires, Argentina.
    Human multiple endocrine neoplasia subtype 2A (MEN 2A) is characterized by medullary thyroid carcinoma, pheochromocytoma and parathyroid hyperplasia or adenoma in the same individual. In this report, a case of a female Rottweiler with medullary thyroid carcinoma, bilateral pheochromocytoma and parathyroid adenoma was described. Clinical manifestations of muscle weakness, polydipsia, polyuria, diarrhea and weight loss were observed. Read More

    Proceedings of the 2016 National Toxicology Program Satellite Symposium.
    Toxicol Pathol 2017 Jan 11;45(1):11-51. Epub 2016 Nov 11.
    1 National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.
    The 2016 annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri" was held in San Diego, CA, at the Society of Toxicologic Pathology's (STP) 35th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers' talks, along with select images that were used by the audience for voting and discussion. Read More

    Aldosterone-Producing Adenoma With a Somatic KCNJ5 Mutation Revealing APC-Dependent Familial Adenomatous Polyposis.
    J Clin Endocrinol Metab 2016 Nov 20;101(11):3874-3878. Epub 2016 Sep 20.
    Hospices Civils de Lyon (J.V., J.G.-D., C.T.), Centre Hospitalier Lyon-Sud, Service d'Endocrinologie, Diabète et Obésité, 69310 Pierre Bénite, France; Inserm, UMRS_970 (F.F.-R., S.B., E.C., M.-C.Z.), Paris Cardiovascular Research Center, 75015 Paris, France; Université Paris Descartes (F.F.-R., S.B., E.C., M.-C.Z.), Sorbonne Paris Cité, 75006 Paris, France; Assistance Publique-Hôpitaux de Paris (F.F.-R., M.-C.Z.), Hôpital Européen Georges Pompidou, Service de Génétique, 75015 Paris, France; Hospices Civils de Lyon (P.L.), Hôpital de la Croix-Rousse, Service de Cardiologie, European Society of Hypertension Excellence Center, 69317 Lyon, France; Université de Lyon (P.L.), CREATIS; CNRS UMR5220; Inserm U1044; INSA-Lyon; Université Claude Bernard Lyon 1, 69100 Lyon, France; Hospices Civils de Lyon (M.D.-P.), Centre Hospitalier Lyon-Sud, Service d'anatomo-pathologie, université Claude Bernard Lyon I, 69310 Pierre Bénite, France; Université Claude Bernard Lyon I (P.L., M.D.-P., C.T.), 69100 Lyon, France; Inserm U1060 (C.T.), Faculté de médecine Lyon sud, 69921 Oullins, France; Hospices Civils de Lyon (J.-L.P.), Centre Hospitalier Lyon-Sud, Service de chirurgie digestive et endocrinienne, 69495 Pierre Bénite, France; Assistance Publique-Hôpitaux de Paris (E.C.), Hôpital Cochin, Service de Biologie Hormonale, 75014 Paris, France.
    Context: Recurrent somatic mutations in KCNJ5, CACNA1D, ATP1A1, and ATP2B3 have been identified in aldosterone-producing adenomas (APAs). The question as to whether they are responsible for both nodulation and aldosterone production is not solved.

    Case Description: We describe the case of a young patient who was diagnosed with severe arterial hypertension due to primary aldosteronism at age 26 years, followed by hemorrhagic stroke 4 years later. Read More

    Different Types of Urinary Steroid Profiling Obtained by High-Performance Liquid Chromatography and Gas Chromatography-Mass Spectrometry in Patients with Adrenocortical Carcinoma.
    Horm Cancer 2016 Dec 1;7(5-6):327-335. Epub 2016 Jul 1.
    Saint Petersburg State University, Saint Petersburg, Russian Federation.
    Urinary steroid profiling (USP) was studied using high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) methods in 108 patients with adrenocortical adenoma (ACA) and in 31 patients with adrenocortical carcinoma (ACC). Thirteen ACC and Cushing's syndrome (ACC-CS) patients had two types of USP as well as 18 ACC patients without hypercortisolism. These four types differed by androgen and glucocorticoid secretion of the adrenal cortex. Read More

    CACNA1H Mutations Are Associated With Different Forms of Primary Aldosteronism.
    EBioMedicine 2016 Nov 4;13:225-236. Epub 2016 Oct 4.
    INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Génétique, Paris, France. Electronic address:
    Primary aldosteronism (PA) is the most common form of secondary hypertension. Mutations in KCNJ5, ATP1A1, ATP2B3 and CACNA1D are found in aldosterone producing adenoma (APA) and familial hyperaldosteronism (FH). A recurrent mutation in CACNA1H (coding for Cav3. Read More

    A case report of subclinical hypercortisolism due to adrenal incidentaloma complicated by myasthenia gravis after adrenalectomy.
    Tumori 2016 Nov 11;102(Suppl. 2). Epub 2016 Nov 11.
    Department of Internal Medicine and Medical Specialties, La Sapienza University, Rome - Italy.
    A 62-year-old woman was admitted for evaluation of an incidentally discovered adrenal mass and hypertension. CT scan revealed a 7 cm mass in the right adrenal gland. After careful examination, the patient was diagnosed with subclinical hypercortisolism (SH). Read More

    [Hypertension etiological work up: Hormonological assessment always before imaging?]
    Presse Med 2016 Oct 31;45(10):871-876. Epub 2016 Aug 31.
    CHU Rangueil, pôle cardiovasculaire et métabolique, service de thérapeutique et HTA, 1, avenue du Professeur-Jean-Poulhès, TSA 50032, 31059 Toulouse cedex 9, France.
    The purpose is to consider the practical management of etiological work up in hypertension, beyond national or international recommendations, leading to consider the prior practice of hormonal assays or renal, renovascular or adrenal imaging. The ease of access to imaging, difficulties to meet the requirements to obtain reliable hormonal assays explain the use of first-line imaging in clinical practice. The renal and adrenal CT angiography provides diagnostic orientation without allowing a formal conclusion. Read More

    Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism.
    Mol Cell Endocrinol 2017 Feb 14;441:124-133. Epub 2016 Oct 14.
    Department of Biochemistry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Department of Medical Education Center, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
    Our group previously purified human and rat aldosterone synthase (CYP11B2 and Cyp11b2, respectively) from their adrenals and verified that it is distinct from steroid 11β-hydroxylase (CYP11B1 or Cyp11b1), the cortisol- or corticosterone-synthesizing enzyme. We now describe their distributions immunohistochemically with specific antibodies. In rats, there is layered functional zonation with the Cyp11b2-positive zona glomerulosa (ZG), Cyp11b1-positive zona fasciculata (ZF), and Cyp11b2/Cyp11b1-negative undifferentiated zone between the ZG and ZF. Read More

    [Primary hyperaldosteronism due to unilateral adrenal hyperplasia with surgical resolution].
    Hipertens Riesgo Vasc 2016 Oct - Dec;33(4):155-158. Epub 2016 Apr 15.
    Servicio de Endocrinología y Nutrición, Hospital Universitario Doctor Peset, Valencia, España; Departamento de Medicina, Universidad de Valencia, Valencia, España; Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, España.
    Unilateral adrenal hyperplasia is a rare cause of primary hyperaldosteronism (around a 3%) that has surgical treatment. A case of a patient with hypertension resistant to conventional therapy in treatment with 7 drugs who presented with primary hyperaldosteronism due to unilateral adrenal hyperplasia is presented. A left adrenalectomy was performed, and the patient had a good clinical response, with no need of any drug after 2 years of surgery. Read More

    Resolution of non-alcoholic steatohepatitis after growth hormone replacement in a pediatric liver transplant patient with panhypopituitarism.
    Pediatr Transplant 2016 Dec 20;20(8):1157-1163. Epub 2016 Oct 20.
    Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.
    NAFLD is a common condition linked to obesity, type 2 diabetes, and metabolic syndrome. Simple hepatic steatosis is a risk factor for inflammatory reactions in the liver (NASH), which may lead to cirrhosis. While the mechanism is unclear, NAFLD and NASH are associated with panhypopituitarism, which in the pediatric population often results from craniopharyngioma or pituitary adenoma and the sequelae of treatment, causing hypothyroidism, adrenal insufficiency, hypogonadotropic hypogonadism, and GH deficiency. Read More

    Long-term Results after CT-Guided Percutaneous Ethanol Ablation for the Treatment of Hyperfunctioning Adrenal Disorders.
    Clinics (Sao Paulo) 2016 Oct 1;71(10):600-605. Epub 2016 Oct 1.
    Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Instituto de Radiologia, Serviço de Intervenção Guiada por Imagem, São Paulo/SP, Brazil.
    Objectives:: To evaluate the safety and long-term efficacy of computed tomography-guided percutaneous ethanol ablation for benign primary and secondary hyperfunctioning adrenal disorders.

    Method:: We retrospectively evaluated the long-term results of nine patients treated with computed tomography-guided percutaneous ethanol ablation: eight subjects who presented with primary adrenal disorders, such as pheochromocytoma, primary macronodular adrenal hyperplasia and aldosterone-producing adenoma, and one subject with Cushing disease refractory to conventional treatment. Eleven sessions were performed for the nine patients. Read More

    Dopamine agonist therapy induces significant recovery of HPA axis function in prolactinomas independent of tumor size: a large single center experience.
    Endocrine 2016 Oct 26;54(1):191-197. Epub 2016 Jul 26.
    Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, USA.
    Our objective was to compare prevalence and rates of recovery of hypothalamic-pituitary-adrenal axis dysfunction in prolactinoma patients before and after dopamine agonist therapy with nonfunctioning pituitary adenoma patients pre-transsphenoidal and post-transsphenoidal surgery. We retrospectively compared hypothalamic-pituitary-adrenal axis function in patients with prolactinomas naïve to dopamine agonist therapy with a cohort of nonfunctioning pituitary adenoma patients matched for gender and tumor size by classification (n = 57; 30 male/27 female; 27 microadenoma/30 macroadenoma). Patients with <52 weeks follow up, previous medical therapy, surgery, or radiation therapy were excluded. Read More

    Worsening of lipid metabolism after successful treatment of primary aldosteronism.
    Endocrine 2016 Oct 14;54(1):198-205. Epub 2016 May 14.
    Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig-Maximilians-Universität, Ziemssenstr. 1, 80336, Munich, Germany.
    Primary aldosteronism (PA) describes the most frequent cause of secondary arterial hypertension. Recently, deterioration of lipid metabolism after adrenalectomy (ADX) for aldosterone-producing adenoma (APA) has been described. We analysed longitudinal changes in lipid profiles in a large prospective cohort of PA patients. Read More

    Benign hormone-secreting adenoma within a larger adrenocortical mass showing intensely increased activity on (18)F-FDG PET/CT.
    Endocrine 2016 Oct 6;54(1):269-270. Epub 2016 May 6.
    Section on Endocrinology and Genetics, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, Building 10, CRC, Room 1-3330, MSC1103, Bethesda, MD, 20892, USA.
    Adrenal adenomas usually show (18)F-FDG activity less than that of the liver parenchyma. However, lipid-poor and hormone-secreting adenomas have been reported to show mild (18)F-FDG avidity. We report on a 51-year-old female with clinical symptoms of hypercortisolemia and a large right adrenal mass detected on CT. Read More

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