2,078,990 results match your criteria Adolescent medicine Philadelphia Pa.[Journal]


Clinical spectrum and prevalence of congenital heart disease in children in Botswana.

Cardiovasc J Afr 2020 Jun 22;31:1-5. Epub 2020 Jun 22.

Department of Paediatric and Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana; Department of Paediatrics, Princess Marina Hospital, Gaborone, Botswana.

Background: Reliable data on congenital heart disease (CHD) from diverse settings is important both for planning health systems in each country and to elucidate possible aetiologies of CHD in different settings. There is a lack of data on the clinical spectrum and prevalence of CHD in Botswana. The aim of this study was to describe the clinical spectrum and prevalence of CHD in Botswana. Read More

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http://dx.doi.org/10.5830/CVJA-2020-021DOI Listing

Different Effects of Cannabis Abuse on Adolescent and Adult Brain.

Authors:
Stefan Dhein

Pharmacology 2020 Jul 6:1-9. Epub 2020 Jul 6.

Institute f. Pharmacology, University Leipzig, Leipzig, Germany,

Cannabis abuse is a common phenomenon among adolescents. The dominant psychoactive substance in Cannabis sativa is tetrahydrocannabinol (THC). However, in the past 40 years the content of the psychoactive ingredient THC in most of the preparations is not constant but has increased due to other breeding and culturing conditions. Read More

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http://dx.doi.org/10.1159/000509377DOI Listing

Parent Technology Use, Parent-Child Interaction, Child Screen Time, and Child Psychosocial Problems among Disadvantaged Families.

J Pediatr 2020 Jul 3. Epub 2020 Jul 3.

Department of Paediatrics & Adolescent Medicine, The University of Hong Kong, Hong Kong. Electronic address:

Objective: To disentangle the pathways between parent technology use, parent-child interactions, child screen time, and child psychosocial difficulties among disadvantaged families in Hong Kong.

Study Design: Parents of 1,254 3-years-olds from the KeySteps@JC project reported on the number of hours their children used electronic devices every day and children's psychosocial behaviors using the Strengths and Difficulties Questionnaire. These parents also reported on their own digital device usage patterns, frequency of parent-child interactions and provided sociodemographic data. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.07.006DOI Listing

Adolescent Female with Severe Thigh Pain after the Splits.

J Pediatr 2020 Jul 3. Epub 2020 Jul 3.

Italy Institute for Maternal and Child Health "IRCCS Burlo Garofolo" Trieste, Italy.

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http://dx.doi.org/10.1016/j.jpeds.2020.06.087DOI Listing

Vaginal Yolk Sac Tumor: A Case Series and Review of the Literature.

J Pediatr Adolesc Gynecol 2020 Jul 3. Epub 2020 Jul 3.

Division of Gynecologic Specialties, Department of Gynecology and Obstetrics, Emory University School of Medicine; Divisions of Pediatric Surgery and Pediatrics, Children's Healthcare of Atlanta.

Objective: Report diagnosis, treatment, and outcomes of vaginal yolk sac tumor (YST) cases at a single institution and review literature on vaginal YST to outline advancements in diagnosis, treatment, and survival.

Design: Retrospective chart review of girls less than 21 years old with pathologic diagnosis of vaginal YST treated at a large children's hospital and summary of a 100-year review of the literature of vaginal yolk sac tumor.

Setting: Children's Healthcare of Atlanta, a tertiary center in Atlanta, Georgia PARTICIPANTS: Female patients < 21 years of age diagnosed with vaginal YST. Read More

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http://dx.doi.org/10.1016/j.jpag.2020.06.020DOI Listing

Links between Child and Adolescent Psychiatric Disorders and Cardiovascular Risk.

Can J Cardiol 2020 Jul 3. Epub 2020 Jul 3.

Department of Psychiatry, Hospital for Sick Children Department of Psychiatry, Faculty of Medicine, University of Toronto.

This narrative review, emphasizing children and adolescents, addresses the link between five psychiatric disorders and cardiovascular risk: attention deficit hyperactivity disorder (ADHD), autism spectrum disorders, anxiety disorders, depression, and bipolar disorders. The evidence regarding cardiovascular risk factors, non-invasive measures of early atherosclerosis, and cardiovascular disease prevalence and/or mortality is summarized. Whereas multiple studies have examined stimulant treatment of ADHD in relation to cardiovascular death, and autonomic-vagal function in autism spectrum disorders, little is known regarding atherosclerotic cardiovascular disease in these conditions. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.06.023DOI Listing

Establishing core outcome domains in pediatric kidney disease: report of the Standardized Outcomes in Nephrology - Children and Adolescents (SONG-KIDS) consensus workshops.

Kidney Int 2020 Jul 3. Epub 2020 Jul 3.

Sydney School of Public Health, The University of Sydney, Sydney, Australia; Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.

Trials in children with chronic kidney disease (CKD) do not consistently report outcomes that are critically important to patients and caregivers. This can diminish the relevance and reliability of evidence for decision-making, limiting the implementation of results into practice and policy. As part of the Standardized Outcomes in Nephrology - Children and Adolescents (SONG-Kids) initiative, we convened two consensus workshops in San Diego, United States (7 patients, 24 caregivers, 43 health professionals; and Melbourne, Australia (7 patients, 23 caregivers, 49 health professionals). Read More

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http://dx.doi.org/10.1016/j.kint.2020.05.054DOI Listing

NF1 optic pathway glioma. Analysing risk factors for visual outcome and indications to treat.

Neuro Oncol 2020 Jul 6. Epub 2020 Jul 6.

Department of Pediatrics, University of Padua, Padua, Italy.

Background: The aim of the project was to identify risk factors associated with visual progression and treatment indications in pediatric patients with Neurofibromatosis type 1 associated optic pathway gliomas (NF1-OPG).

Methods: A multi-disciplinary expert group consisting of ophthalmologists, pediatric neuro-oncologists, neurofibromatosis specialists and neuro-radiologists involved in therapy trials assembled a cohort of children with NF1-OPG from six European countries with complete clinical, imaging and visual outcome datasets. Using methods developed during a consensus workshop, visual and imaging data were reviewed by the expert team and analyzed to identify associations between factors at diagnosis with visual and imaging outcomes. Read More

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http://dx.doi.org/10.1093/neuonc/noaa153DOI Listing

The proportion of non-depressed subjects in a study sample strongly affects the results of psychometric analyses of depression symptoms.

PLoS One 2020 6;15(7):e0235272. Epub 2020 Jul 6.

Department of Child and Adolescent Psychiatry and Psychotherapy (KJPP), University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.

Background: Recent studies have uncovered a peculiar finding: that the strength and dimensionality of depression symptoms' inter-relationships vary systematically across study samples with different average levels of depression severity. Our aim was to examine whether this phenomenon is driven by the proportion of non-affected subjects in the sample.

Methods: Cross-sectional data from the "Cohort Study on Substance Use Risk Factors" was analyzed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235272PLOS

Human Ascariasis: An Updated Review.

Recent Pat Inflamm Allergy Drug Discov 2020 Jul 5. Epub 2020 Jul 5.

Department of Paediatrics, The Chinese University of Hong Kong, and Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital. Hong Kong.

Background: Ascaris lumbricoides is the most common helminthic infection. More than 1.2 billion people have ascariasis worldwide. Read More

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http://dx.doi.org/10.2174/1872213X14666200705235757DOI Listing

Factors Associated with Social Functioning Among Long-Term Cancer Survivors Treated with Hematopoietic Stem Cell Transplantation as Adolescents or Young Adults.

Psychooncology 2020 Jul 6. Epub 2020 Jul 6.

Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA.

Objective: Hematopoietic stem cell transplantation (HSCT) can compromise long-term health and social functioning. We examined the impact of physical and social-emotional factors on the social functioning of long-term adolescent and young adult (AYA) HSCT survivors.

Methods: This cross-sectional analysis included HSCT recipients from the INSPIRE trial [NCT00799461] who received their first transplant between ages 15-39. Read More

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http://dx.doi.org/10.1002/pon.5460DOI Listing

The Use of Social Media to Increase the Impact of Health Research: Systematic Review.

J Med Internet Res 2020 Jul 6;22(7):e15607. Epub 2020 Jul 6.

Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Background: Academics in all disciplines increasingly use social media to share their publications on the internet, reaching out to different audiences. In the last few years, specific indicators of social media impact have been developed (eg, Altmetrics), to complement traditional bibliometric indicators (eg, citation count and h-index). In health research, it is unclear whether social media impact also translates into research impact. Read More

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http://dx.doi.org/10.2196/15607DOI Listing

The impact of adolescents' everyday life experiences on their primary hyperhidrosis treatment- a qualitative study.

J Dermatolog Treat 2020 Jul 6:1-27. Epub 2020 Jul 6.

Department of Dermatology and Allergy Centre, Odense University Hospital, Denmark.

Hyperhidrosis is a disease affecting around 5% of the western population. The qualitative field within hyperhidrosis among adolescents has been sparsely investigated. The aim of this study was to investigate the impact of adolescent hyperhidrosis patients' everyday life experiences on their hyperhidrosis treatment. Read More

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http://dx.doi.org/10.1080/09546634.2020.1789541DOI Listing

Effect of Social Exclusion on Social Maladjustment Among Chinese Adolescents: A Moderated Mediation Model of Group Identification and Parent-Child Cohesion.

Authors:
Ye Zhang Kai Wang

J Interpers Violence 2020 Jul 4:886260520934444. Epub 2020 Jul 4.

Shenyang Normal University, China.

Social exclusion is a covert and widespread social behavior. Different from previous studies on the role of internal and social functions in the relationship between social exclusion and maladjustment, the study aims to explore the influence of individual interaction on the individual-group relationship as well as the impact of relationship changes on adolescent social maladjustment. Based on an integration of social information processing theory and social identification theory, we analyzed the association between social exclusion and adolescents' social maladjustment, especially the mediating role of group identification and the moderating role of parent-child cohesion. Read More

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http://dx.doi.org/10.1177/0886260520934444DOI Listing

Oxygenator impact on voriconazole in extracorporeal membrane oxygenation circuits.

Perfusion 2020 Jul 6:267659120937906. Epub 2020 Jul 6.

The Center for Pediatric Pharmacotherapy LLC, Pottstown, PA, USA.

Introduction: To determine the oxygenator impact on alterations of voriconazole in a contemporary neonatal/pediatric (1/4 inch) and adolescent/adult (3/8 inch) extracorporeal membrane oxygenation circuit including the Quadrox-i oxygenator.

Methods: Simulated closed-loop extracorporeal membrane oxygenation circuits (1/4 and 3/8 inch) were prepared with a Quadrox-i pediatric and Quadrox-i adult oxygenator and blood primed. In addition, 1/4- and 3/8-inch circuits were also prepared without an oxygenator in series. Read More

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http://dx.doi.org/10.1177/0267659120937906DOI Listing

The Development of the Measure of Adolescent Relationship Harassment and Abuse (MARSHA): Input From Black and Multiracial, Latinx, Native American, and LGBTQ+ Youth.

J Interpers Violence 2020 Jul 5:886260520936367. Epub 2020 Jul 5.

Oregon Health Science University - Portland State University, School of Public Health, OR, USA.

This formative research study was designed to collect opinion data from adolescents historically underrepresented in adolescent dating abuse (ADA) research measure development. Eight in-person focus groups and 7 telephone-based one-on-one interviews were conducted with U.S. Read More

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http://dx.doi.org/10.1177/0886260520936367DOI Listing

The paediatric weight management office visit via telemedicine: pre- to post-COVID-19 pandemic.

Pediatr Obes 2020 Jul 6. Epub 2020 Jul 6.

Northern Light Health, Eastern Maine Medical Center, Department of Pediatrics, WOW Pediatric & Adolescent Weight & Cardiometabolic Clinic, Orono, Maine, USA.

Telemedicine is a powerful tool that erases many logistical barriers to care and may increase access. Due to the need for social distancing, the COVID-19 pandemic has temporarily reduced in-person visits for clinical care. Providers, clinical staff and patients are pressed to acutely learn new skills and adapt clinical care through the use of telemedicine whilst administrators, policy makers and regulatory organizations make changes to existing policies to meet this national emergency. Read More

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http://dx.doi.org/10.1111/ijpo.12694DOI Listing

Psychosocial and cultural needs of children with intellectual disability and their families among the Syrian refugee population in Turkey.

J Intellect Disabil Res 2020 Jul 6. Epub 2020 Jul 6.

Department of Mental Health, Ministry of Health, Ankara, Turkey.

Background: Turkey is the country hosting the largest number of refugees from Syria, with currently 3 571 175 million persons. The general health needs of the refugees are being addressed; however, people with intellectual disabilities (IDs), particularly children, are relatively missed. The aim of this study was to identify medical, psychological and social needs of children with ID and their families, among the Syrian refugee population in Turkey, and to define psychosocial and cultural needs for planning of future services. Read More

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http://dx.doi.org/10.1111/jir.12760DOI Listing

Personality correlates of eating pathology severity and subtypes in The National Comorbidity Survey Adolescent Supplement.

J Clin Psychol 2020 Jul 6. Epub 2020 Jul 6.

Department of Psychology, University of Victoria, Victoria, British Columbia, Canada.

Objective: We examined how personality traits are associated with eating pathology (EP) across a range of severities and symptom subtypes.

Method: The National Comorbidity Survey Adolescent Supplement (N = 10,148) was used to compare personality across severities (i.e. Read More

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http://dx.doi.org/10.1002/jclp.23021DOI Listing

Pathways From Childhood Sociomoral Sensitivity in Friendship, Insecurity, and Peer Rejection to Adult Friendship Quality.

Child Dev 2020 Jul 5. Epub 2020 Jul 5.

Max Planck Institute for Human Development.

Across the life span, friendship is an important component of people's support networks. This article explores the developmental roots of adult friendship intimacy and satisfaction, taking into consideration the early interplay between sociomoral sensitivity in friendship, insecurity in peer contexts, and peer rejection. Data (N = 176) came from the longitudinal study "Individual Development and Social Structure. Read More

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http://dx.doi.org/10.1111/cdev.13381DOI Listing

Outcome of surgical treatment of children and adolescents with primary malignant sacral tumours.

Int Orthop 2020 Jul 5. Epub 2020 Jul 5.

Musculoskeletal Tumor Center, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing, 100044, China.

Background: Little is known about the clinical outcome of children and adolescent patients with primary malignant sacral tumours.

Method: We retrospectively reviewed 40 patients with malignant sacral tumours aged ≤ 18 years, receiving surgery based on the previous proposed surgical resection classification at our centre from 2003 to 2018. The following data were collected in the present study: age, gender, radiological images, detailed information of the surgical procedure, pulmonary and other metastasis at presentation, complications, local recurrence, metastasis, and death during the follow-up were recorded from the clinical and follow-up files. Read More

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http://dx.doi.org/10.1007/s00264-020-04641-7DOI Listing

Health Disparities in Transgender and Gender Expansive Adolescents: A Topical Review From a Minority Stress Framework.

J Pediatr Psychol 2020 Jul 6. Epub 2020 Jul 6.

Potocsnak Family Division of Adolescent and Young Adult Medicine.

Objective: To present a topical review of minority stressors contributing to psychosocial and physical health disparities in transgender and gender expansive (TGE) adolescents.

Methods: We conducted a topical review of original research studies focused on distal stressors (e.g. Read More

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http://dx.doi.org/10.1093/jpepsy/jsaa040DOI Listing

The Delayed-Onset Mechanical Pain Behavior Induced by Infant Peripheral Nerve Injury Is Accompanied by Sympathetic Sprouting in the Dorsal Root Ganglion.

Biomed Res Int 2020 16;2020:9165475. Epub 2020 Jun 16.

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.

Background: Sympathetic sprouting in the dorsal root ganglion (DRG) following nerve injuries had been proved to induce adult neuropathic pain. However, it is unclear whether the abnormal sprouting occurs in infant nerve injury.

Methods: L5 spinal nerve ligation (SNL) or sham surgery was performed on adult rats and 10-day-old pups, and mechanical thresholds and heat hyperalgesia were analyzed on 3, 7, 14, 28, and 56 postoperative days. Read More

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http://dx.doi.org/10.1155/2020/9165475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315272PMC

Effect of metabolically healthy obesity on the development of arterial stiffness: a prospective cohort study.

Nutr Metab (Lond) 2020 2;17:50. Epub 2020 Jul 2.

Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Street, Xi'an, 710061 China.

Background: Metabolically healthy obesity (MHO) has been reported to be associated with the development of vascular damage by the carotid intima-media thickness, but the relationship between metabolic health and obesity phenotypes and arterial stiffness is still unknown. Our hypothesized that different metabolic health and obesity phenotypes might be associated with the development of arterial stiffness, and that subjects in MHO phenotype might not have increased risks of arterial stiffness compared with those in metabolically healthy nonobesity phenotype (MHNO), while metabolic unhealthy individuals might have increased risks of arterial stiffness.

Methods: A prospective cohort of 2076 participants (aged 36-48 years) who were enrolled in the Hanzhong Adolescent Hypertension Cohort Study in 2017 was analyzed in a cross-sectional analysis. Read More

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http://dx.doi.org/10.1186/s12986-020-00474-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330959PMC

Co-infection of Cytomegalovirus and Epstein-Barr Virus Diminishes the Frequency of CD56NKG2AKIR NK Cells and Contributes to Suboptimal Control of EBV in Immunosuppressed Children With Post-transplant Lymphoproliferative Disorder.

Front Immunol 2020 17;11:1231. Epub 2020 Jun 17.

Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, The University of Hong Kong, Pok Fu Lam, Hong Kong.

Post-transplant lymphoproliferative disorder (PTLD) is a rare but potentially life-threatening complication, frequently associated with Epstein-Barr virus (EBV), which develops after solid organ or stem cell transplantation. Immunosuppression received by transplant recipients has a significant impact on the development of PTLD by suppressing the function of T cells. The preferential proliferation of NKG2A-positive natural killer (NK) cells during primary symptomatic EBV infection known as infectious mononucleosis (IM) and their reactivity toward EBV-infected B cells point to a role of NK cell in the immune control of EBV. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311655PMC

Prediabetes Induced by a Single Autoimmune B Cell Clone.

Front Immunol 2020 18;11:1073. Epub 2020 Jun 18.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, United States.

While B cells play a significant role in the onset of type-1 diabetes (T1D), little is know about their role in those early stages. Thus, to gain new insights into the role of B cells in T1D, we converted a physiological early pancreas-infiltrating B cell into a novel BCR mouse model using Somatic Cell Nuclear Transfer (SCNT). Strikingly, SCNT-derived B1411 model displayed neither developmental block nor anergy. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314986PMC

Serum Ferritin Correlates With Liver Fat in Male Adolescents With Obesity.

Front Endocrinol (Lausanne) 2020 18;11:340. Epub 2020 Jun 18.

Clinical Institute for Medical and Chemical Laboratory Diagnosis, Medical University Graz, Graz, Austria.

Non-alcoholic fatty liver disease (NAFLD) contributes essentially to the burden of obesity and can start in childhood. NAFLD can progress to cirrhosis and hepatocellular carcinoma. The early phase of NAFLD is crucial because during this time the disease is fully reversible. Read More

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http://dx.doi.org/10.3389/fendo.2020.00340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314945PMC

The Psycho-Physiological Profile of Adolescent Elite Sailors: Testing a Three-Way Moderation Model.

Front Psychol 2020 18;11:1091. Epub 2020 Jun 18.

Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

The present study aimed at extending the work on individual differences, in the relationship between personality traits and the cortisol response, by examining the interaction effects of sex and the role category of Italian adolescent elite dinghy sailors. Seventy athletes completed a self-reported questionnaire including socio-demographic data, information about the role played on board (helmsmen or bowmen) and the Big Five Questionnaire-2. Salivary cortisol samples were collected at 30 min after awakening the day before competitions. Read More

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http://dx.doi.org/10.3389/fpsyg.2020.01091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315764PMC

Development of a Computerized Adaptive Test for Separation Anxiety Disorder Among Adolescents.

Front Psychol 2020 18;11:1077. Epub 2020 Jun 18.

School of Psychology, Jiangxi Normal University, Nanchang, China.

Background: Separation anxiety disorder (SAD) is one of the most common mental disorders among children and adolescents, and it may seriously affect their growth, daily life, and learning. Self-report scales have been used for diagnosis, which require lengthy testing and personnel.

Methods: A total of 1,241 adolescents were recruited from 16 junior- and senior-high schools in China. Read More

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http://dx.doi.org/10.3389/fpsyg.2020.01077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315771PMC

Development and Validation of a Short Version Sport Orientation Questionnaire for Chinese Adolescents (SOQ-CA).

Front Psychol 2020 17;11:1039. Epub 2020 Jun 17.

School of Mathematics and Statistics, Southwest University, Chongqing, China.

A noted decrease in adolescent physical activity in the past decade has resulted in an increase in health risks. Sport orientation correlates closely with physical activity. A sufficient assessment scale that measures an individual's sport orientation is important to measure an adolescent's physical inactivity. Read More

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http://dx.doi.org/10.3389/fpsyg.2020.01039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311786PMC

Epigenetics and Attention-Deficit/Hyperactivity Disorder: New Perspectives?

Front Psychiatry 2020 17;11:579. Epub 2020 Jun 17.

Department of Child and Adolescent Psychiatry, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.3389/fpsyt.2020.00579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311572PMC

Traumatic Events and Substance Use Disorders in Adolescents.

Front Psychiatry 2020 18;11:559. Epub 2020 Jun 18.

Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Dresden, Germany.

Objectives: Adolescents with substance use disorders (SUD) frequently report traumatic events (TEs) and symptoms of post-traumatic stress disorder (PTSD). This study aimed to assess whether lifetime prevalence rates of TEs and PTSD are related to SUD severity in adolescent psychiatric patients.

Methods: We analyzed = 114 self-reports of treatment-seeking German adolescents aged 12 to 18 years, who visited a specialized SUD outpatient unit. Read More

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http://dx.doi.org/10.3389/fpsyt.2020.00559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314975PMC

Differential Role for Activating FcγRIII in Neointima Formation After Arterial Injury and Diet-Induced Chronic Atherosclerosis in Deficient Mice.

Front Physiol 2020 17;11:673. Epub 2020 Jun 17.

Institute for Molecular Cardiovascular Research (IMCAR), University Hospital, RWTH Aachen University, Aachen, Germany.

Atherogenesis and arterial remodeling following mechanical injury are driven by inflammation and mononuclear cell infiltration. The binding of immune complexes (ICs) to immunoglobulin (Ig)-Fc gamma receptors (FcγRs) on most innate and adaptive immune cells induces a variety of inflammatory responses that promote atherogenesis. Here, we studied the role of FcγRIII in neointima formation after arterial injury in atherosclerosis-prone mice and compared the outcome and mechanism to that of FcγRIII in diet-induced "chronic" atherosclerosis. Read More

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http://dx.doi.org/10.3389/fphys.2020.00673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313534PMC

Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices.

Front Neurosci 2020 18;14:614. Epub 2020 Jun 18.

Instituto Gulbenkian de Ciência, Oeiras, Portugal.

Microglial cells have emerged as crucial players in synaptic plasticity during development and adulthood, and also in neurodegenerative and neuroinflammatory conditions. Here we found that decreased levels of Sirtuin 2 (Sirt2) deacetylase in microglia affects hippocampal synaptic plasticity under inflammatory conditions. The results show that long-term potentiation (LTP) magnitude recorded from hippocampal slices of wild type mice does not differ between those exposed to lipopolysaccharide (LPS), a pro-inflammatory stimulus, or BSA. Read More

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http://dx.doi.org/10.3389/fnins.2020.00614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315392PMC

A Protocol for Comparing Dry and Wet EEG Electrodes During Sleep.

Front Neurosci 2020 17;14:586. Epub 2020 Jun 17.

Mobile Health Systems Lab, Department of Health Sciences and Technology, Institute of Robotics and Intelligent Systems, ETH Zürich, Zurich, Switzerland.

Background: Sleep is commonly assessed by recording the electroencephalogram (EEG) of the sleeping brain. As sleep assessments in a lab environment are cumbersome for both the participant and researcher, it would be highly desirable to record sleep EEG with a user-friendly and mobile device. Dry electrodes that are reusable, low-cost, and easy to apply would be an essential component of such a device. Read More

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http://dx.doi.org/10.3389/fnins.2020.00586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313551PMC

Quantitative genome-wide association study of six phenotypic subdomains identifies novel genome-wide significant variants in autism spectrum disorder.

Transl Psychiatry 2020 Jul 5;10(1):215. Epub 2020 Jul 5.

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

Autism spectrum disorders (ASD) are highly heritable and are characterized by deficits in social communication and restricted and repetitive behaviors. Twin studies on phenotypic subdomains suggest a differing underlying genetic etiology. Studying genetic variation explaining phenotypic variance will help to identify specific underlying pathomechanisms. Read More

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http://dx.doi.org/10.1038/s41398-020-00906-2DOI Listing

[Sex/gender ratio of adolescents with gender dysphoria of the Gender Identity Treatment Unit of Asturias].

Rev Int Androl 2020 Jul 2. Epub 2020 Jul 2.

Servicios de Salud del Principado de Asturias (SESPA), Avilés, España.

Background And Objective: Demand from minors with complaints of gender dysphoria has increased in recent years. This increase has been more pronounced in adolescent trans men in some international research studies. The first objective of this research study was to determine the sex/gender ratio of minors requesting a consultation in the Gender Identity Treatment Unit of the Principality of Asturias (UTIGPA) and presenting complaints of gender dysphoria. Read More

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http://dx.doi.org/10.1016/j.androl.2020.03.003DOI Listing

Advances in the diagnosis of pulmonary tuberculosis in children.

Paediatr Respir Rev 2020 May 25. Epub 2020 May 25.

Department of Paediatrics and Child Health, and SA-MRC Unit on Child & Adolescent Health, University of Cape Town and Red Cross War Memorial Children's Hospital, Cape Town, South Africa.

Major challenges still exist in the accurate diagnosis of tuberculosis in children. Algorithms based on clinical and radiological features remain in widespread use despite poor performance. Newer molecular diagnostics allow for rapid identification of TB and detection of drug-resistance in a subset of children, but lack sensitivity. Read More

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http://dx.doi.org/10.1016/j.prrv.2020.05.003DOI Listing

Young Men's Communication With Partners and Contraception Use: A Systematic Review.

J Adolesc Health 2020 Jul 2. Epub 2020 Jul 2.

Heilbrunn Department of Population and Family Health, Columbia University Mailman School of Public Health, New York, New York; Department of Pediatrics, Columbia University Irving Medical Center, New York, New York; New York-Presbyterian Hospital, New York, New York.

Purpose: The rate of adolescent unintended pregnancy in the U.S. is high compared with that in other developed countries. Read More

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http://dx.doi.org/10.1016/j.jadohealth.2020.04.025DOI Listing

Monitoring Adolescents' Receipt of Time Alone From Two National Surveys.

J Adolesc Health 2020 Jul 2. Epub 2020 Jul 2.

Division of Adolescent and Young Adult Medicine, Department of Pediatrics, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, California.

Purpose: Despite professional endorsement and research supporting time alone with a clinician for adolescents, low rates and disparities persist. The purpose of the present analysis was to provide detailed monitoring of time alone estimates in two national surveys that assess time alone for adolescents aged 12-17 years: the National Survey of Children's Health (NSCH) and the Medical Expenditure Panel Survey (MEPS).

Methods: Time alone assessments in the NSCH and the MEPS have different definitions. Read More

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http://dx.doi.org/10.1016/j.jadohealth.2020.05.002DOI Listing

Ventricular Myocardial Deformation Imaging of Patients with Repaired Tetralogy of Fallot.

J Am Soc Echocardiogr 2020 Jul;33(7):788-801

Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, People's Republic of China. Electronic address:

In patients with repaired tetralogy of Fallot (TOF), dysfunction of the right and left ventricles remains an important issue. Adverse right ventricular (RV) remodeling has been related to RV dilation secondary to pulmonary regurgitation, electromechanical dyssynchrony, and myocardial fibrosis. Left ventricular (LV) dysfunction is attributed among other factors to altered ventricular-ventricular interaction. Read More

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http://dx.doi.org/10.1016/j.echo.2020.03.017DOI Listing

Port-a-Cath fracture and migration in paediatric cancer patients: incidence and management at a tertiary care centre - a 15-year experience.

Cardiol Young 2020 Jun 22:1-5. Epub 2020 Jun 22.

Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Introduction: Port-a-Cath or chemoport provides prolonged central venous access for cancer patients requiring prolonged chemotherapy. Prolonged use of chemoport is associated with many complications. Dislodgement and migration of chemoport catheter is a rare and reportable complication with potentially serious consequences. Read More

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http://dx.doi.org/10.1017/S1047951120001390DOI Listing

Contribution of away-from-home food to the energy and nutrient intake among Brazilian adolescents.

Public Health Nutr 2020 Jul 6:1-8. Epub 2020 Jul 6.

University of the State of Rio de Janeiro (UERJ), Social Medicine Institute, Rio de Janeiro, Rio de Janeiro, Brazil.

Objective: To compare the contribution of different food consumption places to the energy and nutrient intake among Brazilian adolescents.

Design: We analysed data from the Study of Cardiovascular Risk in Adolescents - ERICA, carried out in 2013-2014. Foods were categorised into thirty-three food groups. Read More

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http://dx.doi.org/10.1017/S1368980020001573DOI Listing

The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces.

Psychol Med 2020 Jul 6:1-9. Epub 2020 Jul 6.

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.

Background: Brain imaging studies have shown altered amygdala activity during emotion processing in children and adolescents with oppositional defiant disorder (ODD) and conduct disorder (CD) compared to typically developing children and adolescents (TD). Here we aimed to assess whether aggression-related subtypes (reactive and proactive aggression) and callous-unemotional (CU) traits predicted variation in amygdala activity and skin conductance (SC) response during emotion processing.

Methods: We included 177 participants (n = 108 cases with disruptive behaviour and/or ODD/CD and n = 69 TD), aged 8-18 years, across nine sites in Europe, as part of the EU Aggressotype and MATRICS projects. Read More

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http://dx.doi.org/10.1017/S0033291720002111DOI Listing

The longitudinal relationship between dietary intake, physical activity and muscle strength among adolescents.

Br J Nutr 2020 Jun 22:1-32. Epub 2020 Jun 22.

Centre for Population Health, Department of Social and Preventive Medicine, Faculty of Medicine, University Malaya, 50603Kuala Lumpur, Malaysia.

The longitudinal relationship between muscle strength, dietary intake and physical activity among adolescents is not well understood. We investigated the trend and longitudinal effects of dietary intakes and physical activity scores on muscle strength in this adolescent. This prospective cohort study consisted of 436 adolescents (134 males; 302 females), aged 13 years at baseline (2012) and were followed up at the age of 15 (2014) and 17 (2016) years, respectively. Read More

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http://dx.doi.org/10.1017/S0007114520002202DOI Listing

Effects of a physical activity program from diagnosis on cardiorespiratory fitness in children with cancer: a national non-randomized controlled trial.

BMC Med 2020 Jul 6;18(1):175. Epub 2020 Jul 6.

Department of Pediatrics and Adolescent Medicine, The Juliane Marie Center, University Hospital of Copenhagen (Rigshospitalet), Blegdamsvej 9, DK-2100, Copenhagen, Denmark.

Background: Children with cancer experience impaired cardiorespiratory fitness and physical function during and after treatment restricting their possibilities to engage in social activities including sport, leisure activities, and school. The objectives were to determine the effects of classmate-supported, controlled, supervised, in-hospital, physical activity program to preserve cardiorespiratory fitness and physical function from time of diagnosis in children with cancer.

Methods: National non-randomized controlled trial including schoolchildren aged 6-18 years at diagnosis treated with chemo-/radiotherapy. Read More

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http://dx.doi.org/10.1186/s12916-020-01634-6DOI Listing

Knowledge and misconceptions surrounding family planning among Young Maasai women in Kenya.

Glob Public Health 2020 Jul 4:1-10. Epub 2020 Jul 4.

Mukogodo Girls Empowerment Program (MGEP), Laikipia County, Kenya.

Adolescent fertility rates are high in Kenya and increase the likelihood of maternal and infant morbidity and mortality. Our objective was to explore the knowledge, perceptions, and barriers surrounding the use of family planning services among young Maasai women in Laikipia County, Central Kenya. Individual interviews with 50 participants were conducted in Laikipia County, Kenya during June and July of 2019. Read More

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http://dx.doi.org/10.1080/17441692.2020.1788112DOI Listing

Long-term uninterrupted enzyme replacement therapy prevents liver disease in murine model of severe homocystinuria.

Hum Mutat 2020 Jul 5. Epub 2020 Jul 5.

Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Classical homocystinuria (HCU) is an inborn error of metabolism caused by loss of cystathionine beta-synthase (CBS) activity with concomitant buildup of homocysteine. In KO mice, a mouse model of HCU, complete lack of CBS is neonatally lethal. Administration of OT-58, an enzyme therapy for HCU, during the first five weeks of life rescued KO mice survival by preventing liver disease. Read More

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http://dx.doi.org/10.1002/humu.24072DOI Listing
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