2,080,064 results match your criteria Adolescent health medicine and therapeutics[Journal]


Huntingtin gene CAG repeat size affects autism risk: Family-based and case-control association study.

Am J Med Genet B Neuropsychiatr Genet 2020 Jul 11. Epub 2020 Jul 11.

Interdepartmental Program "Autism 0-90", "Gaetano Martino" University Hospital, University of Messina, Messina, Italy.

The Huntingtin (HTT) gene contains a CAG repeat in exon 1, whose expansion beyond 39 repeats consistently leads to Huntington's disease (HD), whereas normal-to-intermediate alleles seemingly modulate brain structure, function and behavior. The role of the CAG repeat in Autism Spectrum Disorder (ASD) was investigated applying both family-based and case-control association designs, with the SCA3 repeat as a negative control. Significant overtransmission of "long" CAG alleles (≥17 repeats) to autistic children and of "short" alleles (≤16 repeats) to their unaffected siblings (all p < 10 ) was observed in 612 ASD families (548 simplex and 64 multiplex). Read More

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http://dx.doi.org/10.1002/ajmg.b.32806DOI Listing

DNMT3B deficiency alters mitochondrial biogenesis and α-ketoglutarate levels in human embryonic stem cells.

Stem Cells 2020 Jul 11. Epub 2020 Jul 11.

Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway.

Embryonic stem cell (ESC) renewal and differentiation is regulated by metabolites that serve as co-factors for epigenetic enzymes. Increase of α-ketoglutarate (α-KG), a co-factor for histone and DNA demethylases, triggers multi-lineage differentiation in human ESCs. To gain further insight how the metabolic fluxes in pluripotent stem cells can be influenced by inactivating mutations in epigenetic enzymes, we generated human ESCs deficient for de novo DNA methyltransferases (DNMT) 3A and 3B. Read More

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http://dx.doi.org/10.1002/stem.3256DOI Listing

Surgical results and pathological analysis of cardiac fibroma in the adolescent and the adult.

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Backgrounds: Disparities may exist between the adolescent and the adult patients with cardiac fibromas in the symptoms, surgical outcomes, and pathological characteristics. The aim of this study was to compare short and midterm surgical outcomes of cardiac fibromas and to compare the biomarker expressions of tumor tissue samples between the adult and the adolescent.

Methods: Consecutive patients with the diagnosis of cardiac fibroma were admitted and received surgeries. Read More

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http://dx.doi.org/10.1111/jocs.14790DOI Listing

Expansion of the phenotypic spectrum of de novo missense variants in kinesin family member 1A (KIF1A).

Hum Mutat 2020 Jul 11. Epub 2020 Jul 11.

Brain and Mitochondrial Research Group, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.

Defects in the motor domain of kinesin family member 1A (KIF1A), a neuron-specific ATP-dependent anterograde axonal transporter of synaptic cargo, are well-recognized to cause a spectrum of neurological conditions, commonly known as KIF1A-associated neurological disorders (KAND). Here we report one mutation-negative female with classic Rett syndrome (RTT) harboring a de novo heterozygous novel variant [NP_001230937.1:p. Read More

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http://dx.doi.org/10.1002/humu.24079DOI Listing

Conflict-driven social change: the case of Syrian children and youth.

Authors:
Angela Veale

Curr Opin Psychol 2020 Jun 9;35:114-118. Epub 2020 Jun 9.

School of Applied Psychology, University College Cork, Ireland. Electronic address:

For Syrian children, the civil war which emerged as a consequence of the Arab Spring has driven massive social change both at the structural level of legal, socioeconomic, educational and health systems, and at the intimate heart of everyday family life. This paper reviews recent research to understand the nature and impact of conflict-driven social change on children's lives. Research from the region and Western resettlement contexts indicates that Syrian refugee children have experienced high levels of exposure to conflict-related traumatic events and elevated rates of mental health difficulties, with evidence to suggest that adolescent girls in the region exhibit poorer well-being than boys. Read More

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http://dx.doi.org/10.1016/j.copsyc.2020.06.001DOI Listing

Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus.

Neurochem Int 2020 Jul 8:104781. Epub 2020 Jul 8.

Laboratory of Neuroscience and Nutrition, Department of Biosciences, Federal University of São Paulo/UNIFESP (Campus Baixada Santista), Santos, SP, Brazil. Electronic address:

Maternal high-fat diet (HFD) consumption can promote a systemic inflammatory condition that may impair the offspring brain development, damaging memory and learning, when it reaches the hippocampus. This study aims to evaluate maternal HFD effects, during pregnancy and lactation, upon dams/mice offspring nutritional status, protein and gene expression of inflammatory pathway (JNK, pJNK and TNF-α), serotonin system molecules (Tryptophan Hydroxylase 2 (TPH2), key-enzyme of serotonin synthesis, serotonin transporter (SERT); 5-HT1A serotonergic receptor (5-HT1A)) and brain derived neurotrophic factor (BDNF) on recently weaned mice offspring hippocampus. Female Swiss mice were fed a control diet (CD, 11,5% fat) or a HFD (45. Read More

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http://dx.doi.org/10.1016/j.neuint.2020.104781DOI Listing

Social defeat stress in adolescent mice induces depressive-like behaviors with reduced oligodendrogenesis.

Neuroscience 2020 Jul 8. Epub 2020 Jul 8.

Department of Neurophysiology and Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan. Electronic address:

Strong stress related to adverse experiences during adolescence can cause mental disorders, as well as affecting brain structure and function. However, the underlying neurobiological mechanisms remain largely unknown. To investigate whether stress induced by adverse experience during adolescence affects oligodendrocyte (OL) remodeling, social defeat stress was applied to 6-week-old adolescent mice for 10 days, followed by behavioral tests and assessments of oligodendrogenesis. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2020.07.002DOI Listing

Fatal Myocarditis in an Adolescent Girl with Evolving Connective Tissue Disease: Correspondence.

Authors:
J B Ghosh

Indian J Pediatr 2020 Jul 10. Epub 2020 Jul 10.

Department of Pediatrics, I.P.G.M.E.R & S.S.K.M Hospital, Kolkata, 700020, India.

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http://dx.doi.org/10.1007/s12098-020-03421-wDOI Listing

The safety and efficacy of one-stage posterior surgery in the treatment of presumed adolescent idiopathic scoliosis associated with intraspinal abnormalities a minimum 3-year follow-up comparative study.

Eur Spine J 2020 Jul 10. Epub 2020 Jul 10.

Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, GongTiNanLu 8#, Chaoyang District, Beijing, 100020, China.

Purpose: Adolescent idiopathic scoliosis (AIS) is a common type of idiopathic scoliosis. Previous studies reported that the incidence of intraspinal abnormalities among the presumed idiopathic scoliosis was 13-43%. Intraspinal abnormalities were also considered increasing the risks of progressing of scoliosis and neurological complications following scoliosis corrective surgery. Read More

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http://dx.doi.org/10.1007/s00586-020-06529-xDOI Listing

Forensic mental health in Europe: some key figures.

Soc Psychiatry Psychiatr Epidemiol 2020 Jul 10. Epub 2020 Jul 10.

Department of Forensic Psychiatry, University of Rostock, Gehlsheimer Straße 20, 18147, Rostock, Germany.

Purpose: While the number of forensic beds and the duration of psychiatric forensic psychiatric treatment have increased in several European Union (EU) states, this is not observed in others. Patient demographics, average lengths of stay and legal frameworks also differ substantially. The lack of basic epidemiological information on forensic patients and of shared indicators on forensic care within Europe is an obstacle to comparative research. Read More

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http://dx.doi.org/10.1007/s00127-020-01909-6DOI Listing

A call to action to address COVID-19-induced global food insecurity to prevent hunger, malnutrition, and eating pathology.

Nutr Rev 2020 Jul 11. Epub 2020 Jul 11.

Division of Adolescent Medicine, Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada. D.K. Katzman is with the Department of Paediatrics, University of Toronto, Toronto, ON, Canada.

The coronavirus 2019 disease (COVID-19) pandemic has led to food shortages, increased food prices, and loss of income. As a result, global food insecurity alerts have been issued. The pandemic threatens millions of children and adolescents and their families currently living with or at risk for development of food insecurity. Read More

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http://dx.doi.org/10.1093/nutrit/nuaa069DOI Listing

Explanatory style in youth self-harm: an Indian qualitative study to inform intervention design.

Evid Based Ment Health 2020 Jul 10. Epub 2020 Jul 10.

Department of Global Health and Social Medicine, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.

Background: There are very few studies that have examined the effectiveness of psychological interventions (PIs) that have been developed and tested in high-income countries to reduce self-harm in low and middle-income countries.

Objective: To evaluate the perspectives and explanatory styles of youth with self-harm and their caregivers to inform the design of an evidence based PI in a non-Western cultural setting. An additional objective was to suggest ways of integrating local practices and traditions to enhance its acceptability. Read More

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http://dx.doi.org/10.1136/ebmental-2020-300159DOI Listing

Laparoscopic sleeve gastrectomy in morbidly obese adolescents: Initial experience of a Pediatric Multidisciplinary Unit.

Arch Pediatr 2020 Jul 7. Epub 2020 Jul 7.

Pediatric Surgery Department, Centro Hospitalar e Universitário de São João, Faculdade de Medicina. Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.

Introduction: Childhood obesity is a significant health problem worldwide, associated with significant metabolic and cardiovascular morbidity. Recent evidence points to metabolic and bariatric surgery as a safe and effective treatment for morbidly obese adolescents. We aim to report the initial results after laparoscopic sleeve gastrectomy (LSG) for adolescent patients in a pediatric center. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.06.003DOI Listing

Fertility preservation rates among transgender women compared with transgender men receiving comprehensive fertility counselling.

Reprod Biomed Online 2020 May 17. Epub 2020 May 17.

Racine IVF Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Research Question: What is the fertility preservation rate among transgender women who have received professional fertility counselling compared with transgender men?

Design: This retrospective cohort study included 56 transgender women and 56 transgender men referred for comprehensive fertility counselling at the Gender Clinic of the Tel Aviv Sourasky Medical Center's Fertility Institute between January 2017 and April 2019. Statistical analyses were performed to compare transgender men with transgender women who preserved fertility and transgender people who preserved fertility and those that did not.

Results: The fertility preservation rate of transgender women was significantly higher than that of transgender men (85. Read More

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http://dx.doi.org/10.1016/j.rbmo.2020.05.003DOI Listing

Do peer social relationships mediate the harmful effects of a housing mobility experiment on boys' risky behaviors?

Ann Epidemiol 2020 May 27. Epub 2020 May 27.

Minnesota Population Center, University of Minnesota, Minneapolis; Department of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis.

Purpose: The purpose of this study was to understand why a housing mobility experiment caused harmful effects on adolescent boys' risky behaviors.

Methods: Moving to Opportunity (MTO) (1994-2010) randomly assigned volunteer families to a treatment group receiving a Section 8 rental voucher or a public housing control group. Our outcome was a global risky behavior index (RBI; measured in 2002, n = 750 boys) measuring the fraction of 10 items the youth engaged in, 6 measuring past 30-day substance use and 4 measuring recent risky sexual behavior. Read More

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http://dx.doi.org/10.1016/j.annepidem.2020.05.007DOI Listing

Risk of Lifetime Psychiatric Morbidity in Adults With Atrial Septal Defect (from a Nation-Wide Cohort).

Am J Cardiol 2020 Aug 19;128:1-6. Epub 2020 May 19.

Department of Cardiothoracic Surgery, Copenhagen University Hospital, Rigshospitalet and Institute of Clinical Medicine, Copenhagen University, Copenhagen, Denmark; Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.

In this nation-wide cohort study we report the first long-term results of the association between having a atrial septal defects (ASD) on psychiatric disorders and use of psychotropic agents. Through population-based registries we included Danish individuals born before 1994 who received an ASD diagnosis between 1959and 2013. We used Cox proportional hazards regression and Fine and Grey competing risk regression to estimate the risk of receiving a psychiatric diagnosis and use of psychotropic medicine compared with a gender and age matched background population cohort. Read More

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http://dx.doi.org/10.1016/j.amjcard.2020.04.047DOI Listing

Creating a Learning Televillage and Automated Digital Child Health Ecosystem.

Pediatr Clin North Am 2020 Aug 19;67(4):707-724. Epub 2020 Jun 19.

Medical Innovation & Care Transformation, KK Women's & Children's Hospital, Singapore; Erasmus School of Health Policy & Management, Erasmus University Rotterdam, Netherlands; SVRZ Cares in Zeeland, Middelburg, Netherlands.

This article explores the impact of digital technologies, including telehealth, teleconsultations, wireless devices, and chatbots, in pediatrics. Automated digital health with the Internet of things will allow better collection of real-world data for generation of real-world evidence to improve child health. Artificial intelligence with predictive analytics in turn will drive evidence-based decision-support systems and deliver personalized care to children. Read More

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http://dx.doi.org/10.1016/j.pcl.2020.04.016DOI Listing

CCL2/CCR2 system in neuroepithelial radial glia progenitor cells: involvement in stimulatory, sexually dimorphic effects of maternal ethanol on embryonic development of hypothalamic peptide neurons.

J Neuroinflammation 2020 Jul 10;17(1):207. Epub 2020 Jul 10.

The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.

Background: Clinical and animal studies show that alcohol consumption during pregnancy produces lasting behavioral disturbances in offspring, including increased alcohol drinking, which are linked to inflammation in the brain and disturbances in neurochemical systems that promote these behaviors. These include the neuropeptide, melanin-concentrating hormone (MCH), which is mostly expressed in the lateral hypothalamus (LH). Maternal ethanol administration at low-to-moderate doses, while stimulating MCH neurons without affecting apoptosis or gliogenesis, increases in LH the density of neurons expressing the inflammatory chemokine C-C motif ligand 2 (CCL2) and its receptor CCR2 and their colocalization with MCH. Read More

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http://dx.doi.org/10.1186/s12974-020-01875-5DOI Listing

Brief report: The effectiveness of Dutch Cell Dogs: A multiple case experimental study.

Clin Child Psychol Psychiatry 2020 Jul 10:1359104520940744. Epub 2020 Jul 10.

Research Institute of Child Development and Education, University of Amsterdam, Amsterdam, Netherlands.

Prison-based dog training programs (DTPs) aim to improve successful rehabilitation after detention. However, empirical evidence for their effectiveness is lacking. To evaluate the effectiveness of a DTP-Dutch Cell Dogs (DCD)-on externalizing behavior, stress, self-esteem, empathy, and treatment motivation, a pilot study with a Multiple Case Experimental Design in six adolescents residing in a juvenile justice center (JJC) was conducted. Read More

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http://dx.doi.org/10.1177/1359104520940744DOI Listing

The Effects of Prebiotic Supplementation with OMNi-LOGiC FIBRE on Fecal Microbiome, Fecal Volatile Organic Compounds, and Gut Permeability in Murine Neuroblastoma-Induced Tumor-Associated Cachexia.

Nutrients 2020 Jul 8;12(7). Epub 2020 Jul 8.

Department of Paediatric and Adolescent Surgery, Medical University of Graz, 8036 Graz, Austria.

Malignant diseases can cause tumor-associated cachexia (TAC). Supplementation with prebiotic non-digestible carbohydrates exerts positive metabolic effects in experimental oncologic diseases. The aim of this project was to assess the effect of prebiotic supplementation with OMNi-LOGiC FIBRE on intestinal microbiome, bacterial metabolism, gut permeability, and inflammation in a murine model of neuroblastoma (NB)-associated TAC. Read More

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http://dx.doi.org/10.3390/nu12072029DOI Listing

Polymorphism, Nasopharyngeal Bacterial Colonization, and the Development of Childhood Asthma: A Prospective Birth-Cohort Study in Finnish Children.

Genes (Basel) 2020 Jul 8;11(7). Epub 2020 Jul 8.

Institute of Biomedicine, Research Center for Infections and Immunity, University of Turku, 20520 Turku, Finland.

We aimed to explore the role of TLR4 (rs4986790) polymorphism in the nasopharyngeal (NP) bacterial colonization and its consequent impact on the development of childhood asthma. A semi-quantitative culture of NP swabs was performed on 473 children at 2 months of age and on 213 children at 13 months of age. polymorphism was analyzed for 396 children. Read More

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http://dx.doi.org/10.3390/genes11070768DOI Listing

Effect of Human Attachment Style on Horse Behaviour and Physiology during Equine-Assisted Activities-A Pilot Study.

Animals (Basel) 2020 Jul 8;10(7). Epub 2020 Jul 8.

Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.

Equine-assisted activities (EAA) for human well-being and health rely on human-horse interactions for therapeutic effect. At-risk participants with mental and emotional difficulties can show poor social skills and functioning relationships, potentially leading to unsuccessful human-horse interaction in EAA. This study addresses the effect of the attachment style (AS) of at-risk adolescents on horse physiology and behaviour during an equine-facilitated learning (EFL) program. Read More

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http://dx.doi.org/10.3390/ani10071156DOI Listing

Single- versus dual-attending strategy for spinal deformity surgery: 2-year experience and systematic review of the literature.

J Neurosurg Spine 2020 Jul 10:1-12. Epub 2020 Jul 10.

2Neurosurgery, Stanford University Hospitals and Clinics, Stanford, California.

Objective: Adult spinal deformity (ASD) surgery is complex and associated with high morbidity and complication rates. There is growing evidence in the literature for the beneficial effects of an approach to surgery in which two attending physicians rather than a single attending physician perform surgery for and oversee the surgical care of a single patient in a dual-attending care model. The authors developed a dual-attending care collaboration in August 2017 in which a neurosurgeon and an orthopedic surgeon mutually operated on patients with ASD. Read More

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http://dx.doi.org/10.3171/2020.3.SPINE2016DOI Listing

Fat talk frequency in high school women: Changes associated with participation in the Body Project.

Body Image 2020 Jul 7;34:196-200. Epub 2020 Jul 7.

Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States. Electronic address:

The Body Project is an evidence-based eating disorder prevention program that aims to prevent the onset of eating disorders by challenging the thin-ideal and promoting body acceptance through dissonance-based activities. One of the key program targets is fat talk, the self-deprecating communication about dissatisfaction with one's weight and shape. Fat talk, family fat talk, and weight concern are associated with body image disturbance and eating disorder development, especially in adolescent girls. Read More

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http://dx.doi.org/10.1016/j.bodyim.2020.06.002DOI Listing

Structural brain differences in pre-adolescents who persist in and recover from stuttering.

Neuroimage Clin 2020 Jun 29;27:102334. Epub 2020 Jun 29.

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam, the Netherlands.

Background: Stuttering is a complex speech fluency disorder occurring in childhood. In young children, stuttering has been associated with speech-related auditory and motor areas of the brain. During transition into adolescence, the majority of children who stutter (75-80%) will experience remission of their symptoms. Read More

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http://dx.doi.org/10.1016/j.nicl.2020.102334DOI Listing

Sevoflurane leads to learning and memory dysfunction via breaking the balance of tPA/PAI-1.

Neurochem Int 2020 Jul 7:104789. Epub 2020 Jul 7.

Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, China. Electronic address:

Exposure to general anesthesia in early childhood may lead to adverse effects on adolescent neurocognition. This study investigated the effects of multiple inhalations of sevoflurane on long-term learning and memory in developing rats, and explored the mechanistic role of the tissue plasminogen activator (tPA)/plasminogen activator inhibitor-1 (PAI-1) fibrinolysis system and its regulatory relationship with the brain derived neurotrophic factor (BDNF) by activation of tropomysin related kinase B (TrkB). After rats were inhaled with sevoflurane for 2h/d for three days, the expression levels of tPA, PAI-1, BDNF, its precursor(proBDNF), TrkB and phosphorylation of TrkB (p-TrkB) were detected at different time points. Read More

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http://dx.doi.org/10.1016/j.neuint.2020.104789DOI Listing

Extragenital Screening for Chlamydia and Gonorrhea Among Adolescents and Young Adults at a Sexual Health Clinic.

Nurs Womens Health 2020 Jul 7. Epub 2020 Jul 7.

Objective: To increase screening rates for oropharyngeal and rectal (extragenital) chlamydia and gonorrhea infections among adolescents and young adults by 20% and for 90% of nurses to demonstrate a change in behavior and knowledge surrounding extragenital screening.

Design: A pre- and posttest design to evaluate nurse knowledge and the percentage of extragenital chlamydia and gonorrhea screenings completed before and after a 2-month intervention period.

Setting: Reproductive health clinic for adolescents and young adults up to age 25 years in the Twin Cities metropolitan area of Minnesota. Read More

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http://dx.doi.org/10.1016/j.nwh.2020.05.007DOI Listing

Videogame-related experiences among regular adolescent gamers.

PLoS One 2020 10;15(7):e0235327. Epub 2020 Jul 10.

Faculty of Labour Sciences, Department of Sociology, Social Work and Public Health, University of Huelva, Huelva, Spain.

The objective of this study was to identify the videogame-related experiences expressed by regular adolescent gamers and to explore the socio-family factors related to these experiences. A cross-sectional observational and descriptive study was carried out with a convenience sample of regular Spanish videogamers between 16 and 18 years old. To measure the use of videogames for evasion and its negative consequences, the Questionnaire of Videogame-Related Experiences (Cuestionario de Experiencias Relacionadas con Videojuegos, CERV) was used and socio-family variables collected, evaluating their relationship with the results of the CERV. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235327PLOS

Perceived Stress, Sexually Transmitted Infection, and Pelvic Inflammatory Disease: Examination of Differences in Associations among Black and White Women.

Sex Transm Dis 2020 Jul 6. Epub 2020 Jul 6.

Department of Population Health, New York University School of Medicine, New York NY.

Introduction: Perceived stress is linked to poor sexual and reproductive health, but its relationship with sexually transmitted infections (STI) is less clear. The elevated burden of stress and STI among Black women suggests a need to examine racial differences in the associations on additive and multiplicative scales.

Methods: Using data from Black and White female participants from Wave IV of the National Longitudinal Study of Adolescent to Adult Health (n=4,744), we examined the association of high stress (scores ≥6 on the Perceived Stress Scale-4) with self-reported past year chlamydia diagnosis; combined curable STI; and lifetime pelvic inflammatory disease using modified Poisson regression with robust variance to estimate prevalence ratios (PRs) and prevalence differences (PDs). Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001232DOI Listing

Influence of local anesthesia on the outcomes of non-surgical periodontal treatment.

Chin Med J (Engl) 2020 Jul 7. Epub 2020 Jul 7.

Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China.

Background: There is limited evidence of the effects of local anesthesia (LA) on outcomes of non-surgical periodontal treatment (NSPT), in particular among the Chinese. This retrospective cohort study aimed to evaluate the effects of LA on short-term treatment outcomes of NSPT and to determine under what circumstances LA should be prescribed to improve these outcomes.

Methods: Data from periodontal examinations of 3980 patients were used. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000903DOI Listing

A Novel Standard for Systematic Reporting of Neuroblastoma Surgery: The International Neuroblastoma Surgical Report Form (INSRF): A Joint Initiative by the Pediatric Oncological Cooperative Groups SIOPEN*, COG**, and GPOH**.

Ann Surg 2020 Jul 7. Epub 2020 Jul 7.

Department of Pediatric Surgery, Université de Paris, Hôpital Necker Enfants-Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.

Objective: To create the first structured surgical report form for NBL with international consensus, to permit standardized documentation of all NBL-related surgical procedures and their outcomes.

Summary Of Background Data: NBL, the most common extracranial solid malignant tumor in children, covers a wide spectrum of tumors with significant differences in anatomical localization, organ or vessel involvement, and tumor biology. Complete surgical resection of the primary tumor is an important part of NBL treatment, but maybe hazardous, prone to complications and its role in high-risk disease remains debated. Read More

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http://dx.doi.org/10.1097/SLA.0000000000003947DOI Listing

Fertility Preservation for Adolescents Receiving Cancer Therapies.

Authors:
Leslie C Appiah

Clin Obstet Gynecol 2020 Jul 8. Epub 2020 Jul 8.

Division Chief of General Obstetrics and Gynecology, Department of Obstetrics and Gynecology, University of Colorado Denver.

According to the National Cancer Institute, ∼300,000 children globally are diagnosed with cancer each year. Advancements in chemotherapy and radiotherapy have revolutionized cancer treatment and improved long-term survival. Although many survivors will remain in good health with disease-free prognoses, three fourths will experience short-term and long-term effects from treatment. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000547DOI Listing

Coping among adolescents with long-term health conditions: a mixed-methods study.

Br J Nurs 2020 Jul;29(13):762-769

Associate Professor, Department of Nursing, University of Sharjah, United Arab Emirates (UAE), School of Nursing, Midwifery and Indigenous Health, Charles Sturt University, Australia, and Sharjah Institute for Medical and Health Research, University of Sharjah, UAE.

Background: Adolescents with long-term health conditions may be at risk of developing psychological comorbidities and adopting ineffective coping mechanisms if they are not adequately supported at home or school.

Aim: To understand the strategies adolescents use when dealing with challenging health situations, and gain an in-depth understanding of the characteristics of their preferred care environment if they have unexpected health crises.

Design: The study used a concurrent mixed-methods design, with data gathered between January and May 2019. Read More

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http://dx.doi.org/10.12968/bjon.2020.29.13.762DOI Listing

Cognitive recovery of children and adolescents with moderate to severe TBI during inpatient rehabilitation.

Disabil Rehabil 2020 Jul 10:1-7. Epub 2020 Jul 10.

Department of Neuropsychology, Children's Healthcare of Atlanta, Atlanta, GA, USA.

Objective: Traumatic brain injury (TBI) is the leading cause of morbidity and mortality in children and adolescents. This study examines the early cognitive-linguistic recovery of pediatric patients who sustained TBI and required inpatient rehabilitation and investigates the contribution of various demographic, clinical, and preinjury factors to recovery.

Methods: A retrospective chart review of children and adolescents, ages 3-20 years, admitted to an inpatient rehabilitation unit. Read More

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http://dx.doi.org/10.1080/09638288.2020.1788176DOI Listing

Cervical Kyphosis in Spinal Muscular Atrophy: A Case Report.

JBJS Case Connect 2020 Apr-Jun;10(2):e1900341

1Department of Orthopedics and Rehabilitation, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 2Department of Orthopaedic Surgery and Rehabilitation, University of Nebraska Medical Center, Omaha, Nebraska.

Case: A 12-year-old boy with spinal muscular atrophy (SMA) Type II presented 5 years after undergoing spinal growing rod placement with cervical kyphosis at C2-3. He underwent anterior cervical discectomy and fusion but 6 years later developed significant kyphosis at the adjacent C3-4 level.

Conclusion: We describe a rare adjacent segment kyphotic condition in a young man with SMA Type II. Read More

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http://dx.doi.org/10.2106/JBJS.CC.19.00341DOI Listing

The Repair of an Acute Pathological Subtrochanteric Femur Fracture Using an Adult 3.5-mm Proximal Humerus Locking Plate in an Adolescent Patient: A Case Report.

JBJS Case Connect 2020 Apr-Jun;10(2):e0491

1Department of Orthopedic Surgery, University of Massachusetts Medical School, Worcester, Massachusetts.

Case: We report a novel case of the successful repair of a pathological fracture of a 14-year-old boy's proximal femur using open reduction and internal fixation with an adult 3.5-mm proximal humerus locking plate.

Conclusion: Successful repair of a pediatric pathologic femur fracture due to an aneurysmal bone cyst may be achieved using an adult proximal humerus locking plate in select patients. Read More

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http://dx.doi.org/10.2106/JBJS.CC.19.00491DOI Listing

Treatment of Locked Pubic Symphysis by Distraction Osteotomy of the Superior Pubic Ramus: A Case Report.

JBJS Case Connect 2020 Apr-Jun;10(2):e0196

1Department of Orthopaedics, Medical Trust Hospital, Cochin, Kerala, India 2Department of Urology, Medical Trust Hospital, Cochin, Kerala, India.

Case: An 18-year-old adolescent sustained a lateral compression injury to the pelvis that featured a locked pubic symphysis with plastic deformation of the sacrum. The pubic bone was entrapped in the opposite obturator foramen and required a novel distraction osteotomy of the superior ramus to restore the symphysis. The patient developed a urethral stricture 3 months after injury that required urethroplasty. Read More

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http://dx.doi.org/10.2106/JBJS.CC.19.00196DOI Listing

Early term elective Caesarean sections did not increase the risk of behavioural problems at six to eight years of age.

Acta Paediatr 2020 Jul 10. Epub 2020 Jul 10.

Perinatal Epidemiology Research Unit, Aarhus University, Aarhus, Denmark.

Aim: Our aim was to explore the under-researched associations between an elective Caesarean section (C-section) at early term or full term gestation and behaviour at 6-8 years of age.

Methods: We identified 1220 eligible children born by elective C-sections at Danish hospital from 2009-2011. Their mothers were randomised to elective C-sections at either 38+3 (early term) or 39+3 (full term) weeks of gestation. Read More

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http://dx.doi.org/10.1111/apa.15468DOI Listing

Integration of Mental Health Screening and Treatment into Cystic Fibrosis Clinics: Evaluation of Initial Implementation in 84 Programs Across the United States.

Pediatr Pulmonol 2020 Jul 10. Epub 2020 Jul 10.

Division of Child and Adolescent Psychiatry, State University of New York at Buffalo.

Background: A large-scale epidemiological study of 6088 individuals with CF and 4102 caregivers in 9 countries documented elevated symptoms of depression and anxiety, leading to international guidelines for annual screening and follow-up. To facilitate national implementation, 84 CF programs funded a mental health coordinators (MHC). Implementation was evaluated after 1 year using the Consolidated Framework for Implementation Research (CFIR) to identify facilitators and barriers. Read More

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http://dx.doi.org/10.1002/ppul.24949DOI Listing

Impact of the coronavirus disease 2019 (COVID-19) pandemic on pediatric oncology care in the Middle East, North Africa, and West Asia Region: A report from the Pediatric Oncology East and Mediterranean (POEM) Group.

Cancer 2020 Jul 10. Epub 2020 Jul 10.

Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, Tennessee.

Background: Childhood cancer is a highly curable disease when timely diagnosis and appropriate therapy are provided. A negative impact of the coronavirus disease 2019 (COVID-19) pandemic on access to care for children with cancer is likely but has not been evaluated.

Methods: A 34-item survey focusing on barriers to pediatric oncology management during the COVID-19 pandemic was distributed to heads of pediatric oncology units within the Pediatric Oncology East and Mediterranean (POEM) collaborative group, from the Middle East, North Africa, and West Asia. Read More

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http://dx.doi.org/10.1002/cncr.33075DOI Listing

Development and validation of an instrument to measure parental factors related to substance use prevention in adolescents.

Curr Drug Res Rev 2020 Jul 10. Epub 2020 Jul 10.

Department of Health Education and Promotion, School of Health, Sabzevar University of Medical Sciences, Sabzevar. Iran.

Background: The average age of using illicit drugs for the first time in adolescents has decreased in Iran over the past years. Studies show that family and environment play a notable role in keeping adolescents away from substances.

Aims: The present study is an attempt to develop and validate a model-based questionnaire to measure parental factors related to substance use prevention in adolescents. Read More

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http://dx.doi.org/10.2174/2589977512666200710171905DOI Listing

Criminal Justice Contacts and Psychophysiological Functioning in Early Adulthood: Health Inequality in the Carceral State.

Authors:
Courtney E Boen

J Health Soc Behav 2020 Jul 10:22146520936208. Epub 2020 Jul 10.

University of Pennsylvania, Philadelphia, PA, USA.

Despite increased attention to the links between the criminal justice system and health, how criminal justice contacts shape health and contribute to racial health disparities remains to be better understood. Using data from the National Longitudinal Study of Adolescent to Adult Health (N = 5,488) and several analytic techniques-including a quasi-treatment-control design, treatment-weighting procedures, and mediation analyses-this study examines how criminal justice contacts shape inflammatory and depressive risk and contribute to black-white health gaps. Findings revealed that incarceration is associated with increased C-reactive protein and depressive risk, particularly for individuals who experienced long durations of incarceration. Read More

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http://dx.doi.org/10.1177/0022146520936208DOI Listing

International traditional Chinese medicine guideline for diagnostic and treatment principles of diabetes.

Ann Palliat Med 2020 Jul 10. Epub 2020 Jul 10.

Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Diabetes mellitus (DM) was one of the most severe public health problems that affected nearly 463 million adults around the world. In addition to insulin and oral hypoglycemic agents, traditional Chinese medicine (TCM) was an effective alternative therapy for diabetes and its complications, and it had been widely used in the Pan-Pacific region, especially in Southeast Asia, however, TCM lacked specialized standards of care for DM in the past, which limited the TCM clinical efficacy of diabetes. Since March 2017, the Endocrinology Committee of World Federation of Chinese Medicine Societies (WFCMS) had invited experts in diabetes, TCM, and international standard setting to work with TCM endocrinologists from the Guideline Development Committee to review the TCM clinical research evidence related to the prevention and treatment of diabetes over the previous 14 years. Read More

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http://dx.doi.org/10.21037/apm-19-271DOI Listing

Bier anemic spots, cyanosis, and urticaria-like eruption (BASCULE) syndrome: Report of two new cases and literature review.

Pediatr Dermatol 2020 Jul 9. Epub 2020 Jul 9.

Department of Dermatology, Cliniques universitaires Saint Luc, Brussels, Belgium.

We herein report two new adolescent cases of Bier anemic spots, cyanosis, and urticaria-like eruption (BASCULE) syndrome. This rare, recently described condition may be associated with postural orthostatic tachycardia syndrome (POTS) and other forms of orthostatic intolerance. This report provides details on two cases and a literature review. Read More

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http://dx.doi.org/10.1111/pde.14213DOI Listing

Granulomatous pigmented purpuric dermatosis in a young adolescent successfully treated with oral pentoxifylline: A case report.

Dermatol Ther 2020 Jul 10:e13995. Epub 2020 Jul 10.

Department of Dermatology, Health Science University Ümraniye Training and Research Hospital, Istanbul, Turkey.

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http://dx.doi.org/10.1111/dth.13995DOI Listing

Patterns of Interactions Between Youth and Resident Stepmothers: A Latent Class Analysis.

Authors:
Todd M Jensen

Fam Process 2020 Jul 10. Epub 2020 Jul 10.

School of Social Work, Family Research and Engagement Specialist, Jordan Institute for Families, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Stepparent-child relationships are a core pillar of stepfamily functioning and well-being. Stepparents can take on a variety of roles in the lives of their stepchildren, ranging from de facto parents to distant acquaintances. There remain important opportunities to explore specific interactional patterns between youth and stepparents, particularly resident stepmothers. Read More

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http://dx.doi.org/10.1111/famp.12556DOI Listing

Making sense of it together: Youth & families co-create sensory modulation assessment and intervention in community mental health settings to optimise daily life.

Aust Occup Ther J 2020 Jul 9. Epub 2020 Jul 9.

School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Vic, Australia.

Introduction: Occupational therapists work collaboratively with young people experiencing mental ill-health to enable meaningful occupational participation in daily life. Sensory modulation is used as a means of developing self-regulation and enabling occupational participation. Published literature on sensory modulation in mental health settings is primarily located within acute inpatient settings and focuses on self-regulation. Read More

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http://dx.doi.org/10.1111/1440-1630.12681DOI Listing

Phase 1, single-dose study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of etelcalcetide in pediatric patients with secondary hyperparathyroidism receiving hemodialysis.

Pediatr Nephrol 2020 Jul 9. Epub 2020 Jul 9.

Children's Mercy Kansas City, Kansas City, MO, USA.

Background: Data on the safety, efficacy of etelcalcetide in children with secondary hyperparathyroidism (sHPT) are limited.

Methods: This phase 1 study (NCT02833857) evaluated the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) of single-dose etelcalcetide (0.035 mg/kg intravenously) in pediatric hemodialysis patients (two cohorts; 1: 12-< 18 years; 2: 2-< 12 years). Read More

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http://dx.doi.org/10.1007/s00467-020-04599-zDOI Listing
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