5,941 results match your criteria Adnexal Tumors

Expression of p40 in Primary Cutaneous Mucinous Carcinoma Versus Primary Mucinous Carcinomas of the Breast and Colon.

Am J Dermatopathol 2021 May 11. Epub 2021 May 11.

Department of Dermatology, Oregon Health and Science University, Portland, OR; J. Chung's work was performed while at Thomas Jefferson University Hospital, Philadelphia, PA; and Departments of Pathology, Anatomy, and Cell Biology, and Dermatology and Cutaneous Biology, Thomas Jefferson University Hospital, Philadelphia, PA.

Background: The transcription factor p63 is a homolog of p53, expressed in basal layers of epithelia and myoepithelial cells. Some studies have suggested that p63 may provide utility in differentiating primary versus metastatic mucinous carcinoma of the skin, given its preferential expression in primary adnexal neoplasms. There have been few studies investigating the expression patterns of p40, an isoform of p63, in primary cutaneous mucinous carcinomas. Read More

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Novel meso-substituted porphyrin derivatives and its potential use in photodynamic therapy of cancer.

BMC Cancer 2021 May 13;21(1):547. Epub 2021 May 13.

Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET and Hospital de Clínicas Gral. José de San Martín, Universidad de Buenos Aires, Córdoba 2351 1er subsuelo, CP1120AAF, Ciudad de Buenos Aires, Argentina.

Background: Photodynamic therapy (PDT) is an anticancer treatment that utilizes the interaction of light and a photosensitiser (PS), promoting tumour cell death mediated by generation of reactive oxygen species. In this study, we evaluated the in vitro photoactivity of four meso-substituted porphyrins and a porphyrin coupled to a fullerene.

Methods: The cell line employed was the LM3 mammary adenocarcinoma, and the PS with the best photokilling activity was administered to mice bearing the LM3 subcutaneously implanted adenocarcinoma. Read More

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Optical Coherence Tomography of Peri-Ocular Skin Cancers: An Optical Biopsy.

Ocul Oncol Pathol 2021 Mar 2;7(2):149-158. Epub 2020 Dec 2.

The MUHC, McGill University Ocular Pathology and Translational Research Laboratory, McGill University, Montreal, Québec, Canada.

Introduction: Optical coherence tomography (OCT) imaging has been used as a diagnostic tool for retinal disease for several years, and OCT apparatuses are becoming increasingly powerful. However, OCT has yet to reach its full potential in ophthalmology clinics. Alike retinal layers, it has been shown that OCT is able to generate cross-sectional images of the skin and allows visualization of skin lesions in a histopathology-like manner. Read More

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Laparoscopic uncontained power morcellation-induced dissemination of ovarian endodermal sinus tumors: A case report.

World J Clin Cases 2021 May;9(13):3212-3218

Department of Obstetrics and Gynecology, Wonkwang University Hospital, Iksan 54645, Jeollabuk-do, South Korea.

Background: Endodermal sinus tumors (ESTs), which arise primarily in children and adolescents, account for 20% of malignant ovarian germ cell tumors, but constitute only 1% of all ovarian malignancies. Treatment of ESTs consists of surgical staging with fertility-sparing surgery and chemotherapy.

Case Summary: A 15-year-old nulliparous patient was diagnosed with disseminated ovarian ESTs after laparoscopic unilateral salpingo-oophorectomy using uncontained power morcellation for treatment of a ruptured solid adnexal mass in another hospital. Read More

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Rhabdomyomatous mesenchymal hamartoma presenting as telangiectasia in a 57-year-old man.

J Cutan Pathol 2021 May 8. Epub 2021 May 8.

Razi laboratory, Rasht, Iran.

Rhabdomyomatous mesenchymal hamartoma (RMH) is a rare congenital malformation of the dermis and subcutaneous tissue. Usually, RMH occurs in the midline of the face and neck region. We described a case of RMH presenting as telangiectasia in a 57-year-old man with a history of pityriasis lichenoides chronicus. Read More

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Sebaceous carcinoma arising from sebaceoma.

Arch Craniofac Surg 2021 Apr 29;22(2):126-130. Epub 2021 Apr 29.

Department of Plastic and Reconstructive Surgery, Soonchunhyang University College of Medicine, Cheonan, Korea.

Sebaceous neoplasms are rare adnexal tumors that can present a challenge to clinicians. Only four cases of sebaceous carcinoma with sebaceoma have been reported in the literature. Herein, we describe the case of a sebaceous carcinoma originating from a sebaceoma in a solitary nodule of the posterior neck. Read More

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Ultrasonography in the Diagnosis of Adnexal Lesions: The Role of Texture Analysis.

Diagnostics (Basel) 2021 Apr 29;11(5). Epub 2021 Apr 29.

Radiology and Imaging Department, County Emergency Hospital, Clinicilor Street 5, 400006 Cluj-Napoca, Romania.

The classic ultrasonographic differentiation between benign and malignant adnexal masses encounters several limitations. Ultrasonography-based texture analysis (USTA) offers a new perspective, but its role has been incompletely evaluated. This study aimed to further investigate USTA's capacity in differentiating benign from malignant adnexal tumors, as well as comparing the workflow and the results with previously-published research. Read More

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Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Follicular Differentiation.

Int J Mol Sci 2021 Apr 30;22(9). Epub 2021 Apr 30.

Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.

Neoplasms derived from follicular tissue are extremely rare. Clinically, they are reported as non-symptomatic, slow-growing nodules. These lesions are mainly benign, but the malignant type can occur. Read More

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Advanced Ovarian Cancer during Pregnancy. Tumour Evolution Analysis and Treatment Approach.

Medicina (Kaunas) 2021 Apr 28;57(5). Epub 2021 Apr 28.

Department of Obstetrics and Gynaecology, Regional University Hospital, 29011 Málaga, Spain.

Background: The possible presence of malignant adnexal mass should be considered during pregnancy. For this reason, it is important to keep in mind such possibility while performing routine obstetric ultrasounds to diagnose asymptomatic ovarian cancer in the early stages.

Case Presentation: 27-year-old pregnant patient with a known adnexal tumour occurring at week 20 and enlarged supraclavicular lymph nodes of 3 cm size who was diagnosed with metastases from low-grade papillary serous ovarian carcinoma. Read More

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Upregulated Expression of Activation-Induced Cytidine Deaminase in Ocular Adnexal Marginal Zone Lymphoma with IgG4-Positive Cells.

Int J Mol Sci 2021 Apr 15;22(8). Epub 2021 Apr 15.

Division of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama 700-8558, Japan.

Immunoglobulin G4-related disease (IgG4-RD) is a systemic disorder characterized by tissue fibrosis and intense lymphoplasmacytic infiltration, causing progressive organ dysfunction. Activation-induced cytidine deaminase (AID), a deaminase normally expressed in activated B-cells in germinal centers, edits ribonucleotides to induce somatic hypermutation and class switching of immunoglobulin. While AID expression is strictly controlled under physiological conditions, chronic inflammation has been noted to induce its upregulation to propel oncogenesis. Read More

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[Clinical and pathological analysis of ocular adnexal diffuse large B-cell lymphoma].

Zhonghua Yan Ke Za Zhi 2021 May;57(5):366-371

Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Nankai University Affiliated Eye Hospital, Clinical College of Ophthalmology of Tianjin Medical University, Tianjin Eye Institute, Tianjin 300020, China.

To summarize the clinical and pathological characteristics of diffuse large B-cell lymphoma of ocular adnexal (OA-DLBCL). A retrospective case series study. Twenty-three cases of OA-DLBCL were collected in Tianjin Eye Hospital from January 2005 to December 2018. Read More

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The role of inflammation biomarkers in differential diagnosis of pelvic tumours of ovarian origin: a single-centre observational study.

Contemp Oncol (Pozn) 2021 15;25(1):7-11. Epub 2021 Apr 15.

Department of Gynaecological Oncology, Metaxa Memorial Cancer Hospital, Piraeus, Greece.

Aim Of The Study: Our aim was to analyse the feasibility of white blood cell and platelet counts along with their ratios as a prognostic factor in patients who underwent surgery for ovarian mass.

Material And Methods: We retrospectively studied the patients admitted in the Department of Gynaecology due to adnexal mass. The potential association of the neutrophil-to-lymphocyte-ratio (NLR), neutrophil-to-monocyte (NMR), platelet-to-lymphocyte (PLR), lymphocyte-to-monocyte (LMR), monocyte-to-platelet, and malignancy was evaluated. Read More

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GATA3-Positive Adnexal Adenocarcinoma: Report of a Confusing Case with a Potential Pitfall of Leading to a Misdiagnosis of Urothelial Carcinoma and a Review of Published Work.

Ann Dermatol 2020 Oct 29;32(5):417-421. Epub 2020 Sep 29.

Department of Dermatology, Kansai Medical University Medical Center, Osaka, Japan.

We describe a confusing case of GATA3-positive adnexal adenocarcinoma with a potential pitfall of leading to a misdiagnosis of urothelial carcinoma. A 62-year-old male presented with a subcutaneous nodule on the right lower abdomen around a scar from surgery for urothelial carcinoma in the right urinary tract, which had been resected 8 years previously. Histologically, atypical cells possessing ample cytoplasm and partial intracytoplasmic lumens were densely grouped in the subcutaneous expansive nodule and bilateral inguinal lymph nodes dissected. Read More

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October 2020

[Correlation between the primary tumor size of endometrial carcinoma and lymph node metastasis and recurrence].

Zhonghua Fu Chan Ke Za Zhi 2021 Apr;56(4):264-270

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China.

To investigate the clinical significance of the primary tumor size in patients with endometrial carcinoma (EC). A total of 385 patients with EC admitted to Peking University People's Hospital from January 2006 to December 2016 with complete follow up data were selected, whose tumor size data before biopsy were retrospectively studied. (1) The mean diameter of the primary tumor was (3. Read More

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[Clinicopathologic characteristics of appendiceal mucinous tumor misdiagnosed as gynecological neoplasms].

C Chen Y Zhang

Zhonghua Zhong Liu Za Zhi 2021 Apr;43(4):472-476

Gynecology Minimally Invasive Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100006, China.

To explore the clinicopathologic features and prognosis of female appendiceal mucinous tumor misdiagnosed as gynecological neoplasm. The clinical data of 12 cases of suspected gynecological neoplasm but confirmed as appendiceal mucinous tumor by operation and pathology in Beijing Obstetrics and Gynecology Hospital hospital from 2010 to 2019 were collected. The clinicopathologic features, treatment and prognosis of these patients were analyzed. Read More

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Desmoplastic Trichoepithelioma With Pseudocarcinomatous Hyperplasia: A Folliculosebaceous Neoplasm in Young Persons.

Am J Dermatopathol 2021 Apr 21. Epub 2021 Apr 21.

UCSF Dermatopathology and Oral Pathology Service, University of California San Francisco, San Francisco, CA; Departments of Pathology and Dermatology, University of California San Francisco, San Francisco, CA; Department of Dermatology, Yale University School of Medicine, New Haven, CT; and Helen Diller Family Cancer Center, University of California San Francisco, San Francisco, CA.

Abstract: Pseudocarcinomatous desmoplastic trichoepithelioma (PDTE) features verrucous squamous epidermal hyperplasia with a jagged undersurface overlying cords of follicular germinative cells in a fibrotic stroma. To date, only 5 cases have been reported. We identified 7 new PDTEs from 2 institutions and reviewed their clinical manifestations and immunohistochemical profile. Read More

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Malignant adnexal tumour of the shoulder-a rare case report.

J Surg Case Rep 2021 Apr 14;2021(4):rjab025. Epub 2021 Apr 14.

Department of General Surgery, Government Stanley Medical College, Tamil Nadu Dr. M.G.R. Medical University, Chennai, Tamil Nadu, India.

Malignant adnexal tumours are a very rare and highly aggressive primary skin neoplasms. Among them, malignant hidradenocarcinoma is a particularly aggressive tumour that arises from the intradermal duct of eccrine sweat glands. It more commonly arises and rarely from a pre-existing hidradenoma. Read More

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Secretory carcinoma of the skin with lymph node metastases and recurrence in both lungs: A case report.

J Cutan Pathol 2021 Apr 21. Epub 2021 Apr 21.

Department of Pathology, Okayama University Hospital, Okayama, Japan.

Secretory carcinoma of the skin is an extremely rare adnexal tumor, histopathologically identical to homologous lesions in the salivary glands and breast tissue. Although this tumor was previously reported as indolent, we report a case of secretory carcinoma of the skin with metastases and recurrence. The patient, a 31-year-old women, had a subcutaneous mass in the right axilla. Read More

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Low-grade mucinous appendiceal neoplasm mimicking an ovarian lesion: A case report and review of literature.

World J Clin Cases 2021 Apr;9(10):2334-2343

Department of Obstetrics and Gynecology, Maternidade Dr. Alfredo da Costa-Centro Hospitalar Universitário de Lisboa Central, Lisbon 2890-495, Portugal.

Background: Appendiceal tumors are rare lesions that may not be easily differentiated from primary ovarian lesions preoperatively, despite the use of advanced diagnostic methods by experienced clinicians.

Case Summary: A 59-year-old G2P2 woman, with chronic pelvic pain, underwent a pelvic ultrasound that revealed an adnexal mass measuring 58 mm × 34 mm × 36 mm, with irregular borders, heterogeneous echogenicity, no color Doppler vascularization and without acoustic shadowing. Normal ovarian tissue was visualized in contact with the lesion, and it was impossible to separate the lesion from the ovary by applying pressure with the ultrasound probe. Read More

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Complete Laparoscopic Removal and Staging of a Large Ovarian Malignancy: A Case Report.

Am J Case Rep 2021 Apr 16;22:e930659. Epub 2021 Apr 16.

Department of Minimally Invasive Surgery, The Marchand Institute for Minimally Invasive Surgery, Mesa, AZ, USA.

BACKGROUND Advances in minimally invasive surgery are essential for the improvement of patient care, overall health care efficiency, and total cost reductions. Morcellation, the technique used in the present case, is often used to aid minimally invasive laparoscopic procedures, whereby larger tissue specimens are broken down and divided to be removed via smaller incisions. Morcellation has become controversial in the medical community owing to the risk of the procedure spreading an occult malignancy. Read More

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Cytological Evaluation of Palpebral Lesions: An Insight into its Limitations Aided with Histopathological Corroboration.

J Microsc Ultrastruct 2021 Jan-Mar;9(1):12-17. Epub 2020 Nov 9.

Department of Pathology, North Bengal Medical College and Hospital, Siliguri, West Bengal, India.

Context: Eyelids by virtue of its unique histomorphology give rise to multitudes of different pathological conditions. Appropriate preoperative cytological diagnoses of these cases are necessary to determine their optimal therapy.

Aims: The aims of this study were to evaluate the utility of various cytological techniques in diagnosing the definite pathology for palpebral lesions and thereby to highlight the drawbacks associated with cytology in this context. Read More

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November 2020

Mohs Surgery Outside Usual Indications: A Review.

Acta Dermatovenerol Croat 2020 Dec;28(7):210-214

Pedro Rodríguez-Jiménez, MD, Dermatology Department, Hospital Universitario de la Princesa, Madrid, Calle Diego de Leon 62, 28006 Madrid, Spain;

The body of literature supporting the use of Mohs micrographic surgery (MMS) in tumors outside the main indications (basal cell carcinoma, squamous cell carcinoma, dermatofibrosacroma protuberans, lentigo maligna) is constantly growing, but it is still based on case reports, case series, or at best institutional case series that focus on a single malignancy. Our aim in this review was to assess use of MMS in an array of rare tumors outside the usual indications. A review was performed using the MEDLINE database and the search engine ClinicalKey®. Read More

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December 2020

Chemotherapy response score as a prognostic tool in patients with advanced stage endometrial carcinoma treated with neoadjuvant chemotherapy.

Int J Gynecol Cancer 2021 Apr 8. Epub 2021 Apr 8.

Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois, USA

Background: Chemotherapy response score (CRS) applied to interval debulking specimens quantifies histopathologic response to neoadjuvant chemotherapy in patients with advanced ovarian carcinoma and correlates with progression-free and overall survival.

Objective: To investigate whether the chemotherapy response score could be applied to interval debulking specimens in patients with advanced endometrial carcinoma and be a prognostic indicator.

Methods: The study included patients with clinical stage III-IV endometrial carcinoma who received neoadjuvant chemotherapy followed by interval debulking surgery. Read More

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Ultrasonographic features of eccrine spiradenoma: A case report.

Medicine (Baltimore) 2021 Apr;100(14):e25469

Department of Ultrasound, Hebei General Hospital, Shijiazhuang, Hebei, China.

Rationale: Eccrine spiradenoma (ES) is a rare benign skin adnexal tumor originating from eccrine sweat glands. The features of ES on ultrasonography (US) have received little attention. Therefore, we report the sonographic findings in a case of an ES that originated from the abdominal wall and discuss the previously reported cases. Read More

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Second primary malignancies after ocular adnexal lymphoma diagnosis.

BMC Ophthalmol 2021 Apr 7;21(1):162. Epub 2021 Apr 7.

Baylor College of Medicine, Department of Ophthalmology-Cullen Eye Institute, 1977 Butler Boulevard, Houston, TX, 77030, USA.

Background: Although studies have investigated the risk of second primary malignancies (SPMs) associated with lymphoma of various sites, limited studies have investigated this risk in patients with lymphoma originating within the ocular adnexa. We conducted a retrospective study to assess incidence of secondary malignancies in patients with a prior diagnosis of ocular adnexal lymphoma (OAL) and to determine latency periods and age-groups at increased risk for SPM occurrence.

Methods: Retrospective analysis was performed on data obtained from Surveillance, Epidemiology, and End Results (SEER) 9 database. Read More

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Eccrine spiradenoma: a rare adnexal tumour with atypical presentation: A case report.

J Pak Med Assoc 2021 02;71(2(A)):553-555

Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.

First described in 1934, eccrine spiradenoma (ES) is a rare, benign adnexal tumour arising from eccrine sweat glands. It commonly presents as a slow-growing nodule on the upper trunk, and head and neck region, mostly in the age bracket of 15-35 years, with no gender preference. While no established guidelines exist for optimal management of malignant ES, some therapies have been studied. Read More

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February 2021

Magnetic Resonance Imaging Evaluation of Ectopic Pregnancy: A Value-Added Review.

J Comput Assist Tomogr 2021 Mar 12. Epub 2021 Mar 12.

From the Department of Radiology, University of Florida College of Medicine, Jacksonville, FL Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX Department of Obstetrics and Gynecology, University of Florida College of Medicine, Jacksonville, FL.

Abstract: Ectopic pregnancy (EP) is a known cause of maternal mortality and may be misdiagnosed in up to 50% of pregnant female individuals (Ann Emerg Med. 1996;28(1):10-17). Magnetic resonance imaging, with its superior soft tissue resolution, is a valuable alternative diagnostic modality to diagnose EP when transvaginal ultrasound results are inconclusive. Read More

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Recurrent and metastatic female adnexal tumor of probable Wolffian origin: A case report and review of the literature.

Medicine (Baltimore) 2021 Apr;100(13):e25377

Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University.

Rationale: Female adnexal tumors of probable Wolffian origin (FATWOs) are rare gynecologic neoplasms arising from the mesonephric duct remnants. Less than 90 cases have been reported in the English literature. Although most cases of FATWO are considered benign, recurrence and metastasis may occur in very few cases during the course of the disease. Read More

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Ophthalmic Presentation and Outcomes for Malignant Sinonasal Tumors.

Ophthalmic Plast Reconstr Surg 2021 Mar 24. Epub 2021 Mar 24.

Adnexal Service, Moorfields Eye Hospital, London, United Kingdom.

Purpose: To evaluate the ophthalmic clinical features and functional outcomes for patients with malignant sinonasal tumors who initially presented with orbital symptoms.

Patients And Methods: Retrospective chart review for patients seen at Moorfields Eye Hospital between 1997 and 2020. Patient demographics and clinical features, radiology, histology, and treatment outcomes were reviewed. Read More

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