5,364 results match your criteria Adnexal Tumors


Benign Ovarian Tumors in Pregnancy: A Case Report of Metachronous Ipsilateral Recurrent Mucinous Cystadenoma in Initial Pregnancy and Mature Cystic Teratoma in Subsequent Pregnancy.

Cureus 2019 Jan 3;11(1):e3818. Epub 2019 Jan 3.

Obstetrics and Gynecology, East Tennessee State University, Quillen College of Medicine, Johnson City, USA.

Mucinous cystadenomas of the ovary are benign epithelial neoplasms that can grow rapidly during pregnancy. They may cause ovarian torsion, virilization, inferior vena cava syndrome, and even preterm labor and fetal growth restriction. Various theories exist regarding the pathogenesis of these tumors. Read More

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http://dx.doi.org/10.7759/cureus.3818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402862PMC
January 2019

Differential Expression of PLAG1 in Apocrine and Eccrine Cutaneous Mixed Tumors: Evidence for Distinct Molecular Pathogenesis.

Am J Dermatopathol 2019 Feb 28. Epub 2019 Feb 28.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Cutaneous mixed tumors, also known as chondroid syringomas, are benign adnexal neoplasms that share histomorphologic features with pleomorphic adenomas of the salivary gland. Recent work suggests that the similarity between these 2 tumor types extends to the molecular level because both harbor identical chromosomal rearrangements involving the PLAG1 gene. The resulting nuclear PLAG1 overexpression can be detected by immunohistochemistry and has become a useful diagnostic adjunct for both tumor types. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001393DOI Listing
February 2019
1 Read

Ultrasonographic and multimodal imaging of pediatric genital female diseases.

J Ultrasound 2019 Feb 19. Epub 2019 Feb 19.

Department of Imaging, Bambino Gesù Children's Hospital Research Institute, P.za S.Onofrio 4, Via Torre di Palidoro, Palidoro, Rome, Italy.

Ultrasonography is the first-line imaging modality in the evaluation of the female pelvis in childhood and adolescence, because it is easy to perform, non-invasive and it does not require sedation. The transabdominal approach is preferred in children and adolescents, after filling the bladder to move away the bowel loops from the pelvis. The probe frequency must be adapted to age, thickness of tissues and depth of the structures under examination. Read More

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http://dx.doi.org/10.1007/s40477-019-00358-5DOI Listing
February 2019

Assessment of the diagnostic value of using serum CA125 and GI-RADS system in the evaluation of adnexal masses.

Medicine (Baltimore) 2019 Feb;98(7):e14577

Department of Gynecology and Obstetrics, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu.

Cancer antigen 125 (CA125) is a valuable tumor marker for ovarian cancer. Gynecology Imaging Reporting and Data System (GI-RADS) is proved to be effective at identifying the adnexal masses. We investigated whether the combination of these two methods can improve the diagnostic accuracy of ovarian cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000014577DOI Listing
February 2019
1 Read
5.723 Impact Factor

Risk of complications in patients with conservatively managed ovarian tumours (IOTA5): a 2-year interim analysis of a multicentre, prospective, cohort study.

Lancet Oncol 2019 Mar 5;20(3):448-458. Epub 2019 Feb 5.

Department of Development and Regeneration, KU Leuven, Leuven, Belgium; Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium. Electronic address:

Background: Ovarian tumours are usually surgically removed because of the presumed risk of complications. Few large prospective studies on long-term follow-up of adnexal masses exist. We aimed to estimate the cumulative incidence of cyst complications and malignancy during the first 2 years of follow-up after adnexal masses have been classified as benign by use of ultrasonography. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183083
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http://dx.doi.org/10.1016/S1470-2045(18)30837-4DOI Listing
March 2019
3 Reads

Bowen Disease with Invasive Mucin-Secreting Sweat Gland Differentiation: Report of a Case and Review of the Literature.

J Cutan Pathol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority, Central Zone (Halifax), NS,, Canada.

Bowen Disease (BD) with divergent adnexal differentiation is a rare composite cutaneous tumor featuring different phenotypic elements. Sebaceous, poroid and trichilemmal invasive components have been described in this setting and very infrequent reports of mucinous glandular differentiation are extant. Clinically these tumors are not sufficiently distinctive to enable recognition without histopathological evaluation. Read More

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http://dx.doi.org/10.1111/cup.13437DOI Listing
February 2019
2 Reads

Outcomes of fertility-sparing surgery in ovarian juvenile granulosa cell tumor.

Int J Gynecol Cancer 2019 Feb 6. Epub 2019 Feb 6.

Department of Gynecology Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Objective: To analyze the clinical characteristics, diagnosis, and treatment of ovarian juvenile granulosa cell tumor.

Methods: The clinical and pathological data of six patients with ovarian juvenile granulosa cell tumor was collected.

Results: The mean age of disease onset was 20. Read More

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http://ijgc.bmj.com/lookup/doi/10.1136/ijgc-2018-000083
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http://dx.doi.org/10.1136/ijgc-2018-000083DOI Listing
February 2019
5 Reads

Proliferating trichilemmal tumour: diagnostic challenge on core biopsy.

BMJ Case Rep 2019 Feb 1;12(2). Epub 2019 Feb 1.

Head and Neck Pathology Unit, Histopathology, University College London Hospitals, NHS Foundation Trust, London, UK.

A 70-year-old woman presented with a 10-month history of an irregular mass in the left lateral nape of her neck which had recently increased in size rapidly. Ultrasound-guided core needle biopsy was obtained, and the tumour was diagnosed as a well-differentiated squamous cell carcinoma. Further imaging studies failed to demonstrate additional malignant characteristics. Read More

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http://dx.doi.org/10.1136/bcr-2018-226567DOI Listing
February 2019
2 Reads

Laparoscopy versus open surgery for adnexal masses in pregnancy: a meta-analytic review.

Arch Gynecol Obstet 2019 Mar 31;299(3):625-634. Epub 2019 Jan 31.

Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.

Purpose: The objective of this meta-analysis is to investigate and compare the pregnancy outcomes of laparoscopy and open surgery in the treatment of ovarian tumors during pregnancy.

Methods: Search was conducted using MEDLINE, EMBASE, and Cochrane Databases from January 1990 to November 2018. A broad search strategy was used to identify studies comparing laparoscopy and open surgery in pregnancy. Read More

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http://dx.doi.org/10.1007/s00404-018-05039-yDOI Listing
March 2019
1 Read

18F-FDG PET/CT for staging and response assessment of primary parotid MALT lymphoma with multiple sites involvement: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14270

Department of Nuclear Medicine, Lanzhou University Second Hospital, Lanzhou University.

Rationale: Mucosa-associated lymphoid tissue (MALT) lymphoma is an extranodal low-grade B cell lymphoma that generally exhibits an indolent clinical course. Currently, the application of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in MALT lymphoma is still controversial. Herein, we reported a case of using F-FDG PET/CT for staging and response assessment of primary parotid MALT lymphoma with multiple sites involvement. Read More

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http://dx.doi.org/10.1097/MD.0000000000014270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380729PMC
February 2019
9 Reads

Smooth Muscle Tumors of the Visceral Adnexal and Uterine Ligaments and Adnexal Connective Tissue: A Clinicopathologic Study of 67 Cases.

Int J Gynecol Pathol 2019 Jan 29. Epub 2019 Jan 29.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (V.P., J.K.S.) Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland (D.X.) Department of Pathology, University of Florida, Gainesville, Florida (M.F.).

The endopelvic fascia is a biomechanical network of supportive tissue that suspends and secures the female reproductive organs to the pelvic sidewall. Several visceral adnexal and uterine ligaments are part of this framework, and we have observed that smooth muscle tumors (SMTs) arising from these structures morphologically resemble gynecologic smooth muscle neoplasms. To determine whether gynecologic smooth muscle tumor criteria for malignancy are valid in these tumors, we evaluated the morphologic features of 67 tumors from 67 patients and correlated our findings with patient outcome. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000578DOI Listing
January 2019
1 Read

[Clinicopathological analysis of cervical basaloid squamous cell carcinoma].

Zhonghua Fu Chan Ke Za Zhi 2019 Jan;54(1):7-12

Department of Pathology, General Hospital of PLA, Beijing 100853, China.

To investigate the clinical and histopathological features of cervical basal squamous cell carcinoma (BSCC). A retrospective analysis of 10 cases of cervical BSCC was carried out. The clinical data and all the pathological sections were reviewed, the related immunohistochemical results were statistically analyzed, the clinicopathological features were analyzed, and then followed the prognosis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2019.01.003DOI Listing
January 2019
12 Reads

Clinical, genetic and experimental studies of the Brooke-Spiegler (CYLD) skin tumor syndrome.

J Plast Surg Hand Surg 2019 Apr 24;53(2):71-75. Epub 2019 Jan 24.

a Sahlgrenska Cancer Center, Department of Pathology , University of Gothenburg , Gothenburg , Sweden.

Brooke-Spiegler syndrome (BSS; a.k.a. Read More

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https://www.tandfonline.com/doi/full/10.1080/2000656X.2018.1
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http://dx.doi.org/10.1080/2000656X.2018.1547736DOI Listing
April 2019
7 Reads

Multiple benign adnexal tumours: Anything but benign.

Australas J Dermatol 2019 Jan 22. Epub 2019 Jan 22.

St Vincent's Hospital, Sydney, New South Wales, Australia.

Muir Torre syndrome is an autosomal dominant disorder characterised by germline mutations in mismatch repair genes involved in DNA repair, leading to microsatellite instability and a propensity to tumour formation. We report a case of a 67-year-old gentleman who underwent biopsy of a smooth nodular lesion on the nasal tip, histopathologically consistent with sebaceous adenoma. Immunohistochemistry suggested a loss of MSH6. Read More

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http://doi.wiley.com/10.1111/ajd.12989
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http://dx.doi.org/10.1111/ajd.12989DOI Listing
January 2019
13 Reads

Cytokeratin expression in epidermal stem cells in skin adnexal tumors.

Oncol Lett 2019 Jan 8;17(1):927-932. Epub 2018 Nov 8.

Department of Pathology, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China.

The expression levels of seven types of cytokeratin (CK) in different kinds of skin adnexal tumors were evaluated. One hundred and thirty-two patients with different kinds of skin adnexal tumors admitted and treated in the Department of Dermatology of Dongying People's Hospital from May 2013 to May 2015 were selected and underwent tissue section staining. Another 20 cases of normal skin were enrolled as the control group. Read More

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http://dx.doi.org/10.3892/ol.2018.9679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312935PMC
January 2019
1 Read

Proceedings of the Association for Research in Vision and Ophthalmology and Champalimaud Foundation Ocular Oncogenesis and Oncology Conference.

Transl Vis Sci Technol 2019 Jan 9;8(1). Epub 2018 Jan 9.

Scheie Eye Institute and Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA, USA.

The 2018 Ocular Oncogenesis and Oncology Conference was held through a partnership of the Association for Research in Vision and Ophthalmology (ARVO) and the Champalimaud Foundation. Twenty-one experts from international ocular oncology centers, from the Champalimaud Clinical Centre and the Champalimaud Foundation Cancer Research Program, and from patient advocacy organizations, delivered lectures on subjects that ranged from global ocular oncology, to basic research in mechanisms of ocular malignancy, to clinical research in ocular cancers, and to anticipated future developments in the area. The scientific program of the conference covered a broad range of ocular tumors-including uveal melanoma, retinoblastoma, ocular surface tumors, and adnexal and intraocular lymphomas-and pathogenesis and management were deliberated in the context of the broader systemic cancer discipline. Read More

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http://tvst.arvojournals.org/article.aspx?doi=10.1167/tvst.8
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http://dx.doi.org/10.1167/tvst.8.1.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333107PMC
January 2019
11 Reads

Low-grade Appendiceal Mucinous Neoplasm Presenting as Adnexal Mass: A Case Report.

Cureus 2018 Nov 10;10(11):e3568. Epub 2018 Nov 10.

Surgery, Aretaieio Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, GRC.

An appendiceal mucocele is a dilatation of the appendix and it is the result of benign or malignant diseases, which cause the obstruction of the appendix and the consequent accumulation of mucus secretion. The preoperative diagnosis is difficult due to non-specific clinical manifestations of the disease. We present a case of an 83-year-old female patient with a history of breast cancer that was referred to our hospital for an evaluation of a right adnexal mass discovered during her yearly follow-up. Read More

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http://dx.doi.org/10.7759/cureus.3568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329616PMC
November 2018
6 Reads

Skin Adnexal Tumors in Plain Language: A Practical Approach for the General Surgical Pathologist.

Arch Pathol Lab Med 2019 Jan 14. Epub 2019 Jan 14.

From the Department of Pathology, University of Arkansas for Medical Sciences, Little Rock.

Context.—: Skin adnexal tumors, those neoplasms deriving from hair follicles and sweat glands, are often a source of confusion amongst even experienced pathologists. Many well-described entities have overlapping features, tumors are often only partially sampled, and many cases do not fit neatly into well-established classification schemes. Read More

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http://dx.doi.org/10.5858/arpa.2018-0189-RADOI Listing
January 2019
1 Read

PD-L1 and PD-L2 Are Expressed in Conjunctival Invasive Squamous Cell Carcinoma: Therapeutic Implications.

Am J Ophthalmol 2019 Jan 8. Epub 2019 Jan 8.

Division of Head and Neck Pathology, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Purpose: Novel cancer immunotherapies, called immune checkpoint inhibitors, have demonstrated clinical efficacy in the treatment of squamous cell carcinomas of the head and neck. Tissue expression of programmed death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2) has been shown to predict tumor response to these drugs. We examine the expression of prognostic immune biomarkers, PD-L1 and PD-L2, in invasive ocular surface squamous neoplasia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394193000
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http://dx.doi.org/10.1016/j.ajo.2018.12.020DOI Listing
January 2019
6 Reads
3.871 Impact Factor

A giant trichoblastic carcinoma.

Arch Craniofac Surg 2018 Dec 27;19(4):275-278. Epub 2018 Dec 27.

Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.

Trichoblastic carcinoma usually occurs as a malignant transformation of the trichoblastoma, but is very rare. A 25-year-old man was admitted with trichoblastoma in the nuchal area with frequent recurrences since birth. The preoperative neck magnetic resonance image revealed lobulated soft tissue lesions involving superficial fascia and infiltrating into both proximal trapezius muscles. Read More

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http://dx.doi.org/10.7181/acfs.2018.02124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325323PMC
December 2018
1 Read

Histological findings and pathologic diagnosis of spiradenocarcinoma: A case series and review of the literature.

J Cutan Pathol 2019 Apr 31;46(4):243-250. Epub 2019 Jan 31.

Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: Atypical spiradenoma and spiradenocarcinoma present a diagnostic challenge. We aim to assess the significance of certain histologic features, which may facilitate diagnosis of these tumors.

Methods: A natural language search for cases of "atypical spiradenoma" and "spiradenocarcinoma" diagnosed between 2009 and 2018 was performed. Read More

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http://doi.wiley.com/10.1111/cup.13408
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http://dx.doi.org/10.1111/cup.13408DOI Listing
April 2019
3 Reads

Rapidly Enlarging Malignant Proliferating Trichilemmal Tumor in a Young Female

J Drugs Dermatol 2018 12;17(12):1325-1327

Malignant proliferating trichilemmal tumors are rare adnexal neoplasms that most commonly occur on the scalp in elderly women. These tumors are associated with recurrence and even nodal or distant metastatic spread. Here we describe a 38-year-old patient who presented with a scalp nodule that was diagnosed as a high-grade malignant proliferating trichilemmal tumor. Read More

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December 2018
7 Reads

Somatic genetic alterations in synchronous and metachronous low-grade serous tumours and high-grade carcinomas of the adnexa.

Histopathology 2019 Mar 15;74(4):638-650. Epub 2019 Jan 15.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK.

Aims: Low-grade serous carcinomas (LGSCs) and their precursors serous borderline tumours (SBTs) characteristically harbour mutations in BRAF, KRAS or NRAS but rarely in TP53, whereas high-grade serous carcinomas (HGSCs) are characterised by frequent TP53 mutations but rare BRAF, KRAS or NRAS mutations. In a small subset of cases, LGSCs and/or SBTs develop into high-grade tumours, including HGSCs and poorly differentiated carcinomas (PDCs). Here, we sought to define the repertoire of somatic genetic alterations in low-grade serous tumours and synchronous or metachronous high-grade adnexal carcinomas. Read More

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http://doi.wiley.com/10.1111/his.13796
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http://dx.doi.org/10.1111/his.13796DOI Listing
March 2019
13 Reads

Periocular Sebaceous Carcinoma With Apocrine Differentiation: A Case Report and Review of the Literature.

Int J Surg Pathol 2018 Dec 6:1066896918816806. Epub 2018 Dec 6.

1 Centro Hospitalar São João, Porto, Portugal.

A 61-year-old man presented with a dome-shaped tumor in the right eyelid. Histology revealed a cutaneous neoplasm with lobular growth pattern. It was composed of large basaloid cells, cells with sebaceous differentiation, and glandular structures with apocrine features. Read More

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http://dx.doi.org/10.1177/1066896918816806DOI Listing
December 2018
3 Reads

Collagenous Spherulosis in Well-Differentiated Papillary Mesothelioma in a Female With Multilocular Peritoneal Inclusion Cysts.

Int J Surg Pathol 2018 Dec 6:1066896918816815. Epub 2018 Dec 6.

1 Rashid Hospital, Dubai, UAE.

Multilocular peritoneal inclusion cysts are mesothelial tumor-like lesions with or without small foci of florid papillary mesothelial hyperplasia that might simulate serous epithelial papillary lesions or well-differentiated papillary mesothelioma (WDPM) of the peritoneum. The papillary cores in papillary mesothelial hyperplasia and in WDPM display a variety of different histomorphologic features. To our knowledge, collagenous spherulosis in WDPM was not previously described or illustrated in the literature. Read More

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http://dx.doi.org/10.1177/1066896918816815DOI Listing
December 2018
14 Reads

Cancer overturned: Endometrioma mimicking granulosa cell tumor and the importance of FOXL2 analysis.

Gynecol Oncol Rep 2019 Feb 22;27:8-10. Epub 2018 Nov 22.

Department of Obstetrics and Gynecology, Division of Gynecology and Gynecologic Subspecialties, University of Wisconsin Hospital and Clinics, Madison, WI, United States.

Background: Various ovarian neoplasms may show histological findings that are morphologically indistinguishable from adult granulosa cell tumor (AGCT).

Case Presentation: A 36 year-old women presented with left lower extremity pain and numbness. Ultrasound revealed a 10 cm left adnexal mass treated with ovarian cystectomy. Read More

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http://dx.doi.org/10.1016/j.gore.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262800PMC
February 2019
3 Reads

Immunoreactivity for Sox10 in Basaloid Neoplasms of The Skin.

Appl Immunohistochem Mol Morphol 2019 Feb;27(2):114-118

Section of Dermatopathology, Division of Surgical Pathology-Cytopathology, University of Virginia Medical Center, Charlottesville, VA.

Basaloid tumors of the skin pose a diagnostic challenge to pathologists, because the differential diagnosis is broad, sometimes with subtle differentiating features. We evaluated SOX10 expression in 120 primary cutaneous tumors with epidermal, sweat glandular, neuroendocrine/neuroectodermal, follicular, and sebaceous lineages. Our findings were compared with those of previous studies that evaluated SOX10 in tumors of the skin. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000721DOI Listing
February 2019
3 Reads

The value of MR-detectable ipsilateral ovaries in characterizing the origin and malignancy of an adnexal tumors.

Eur J Radiol 2018 Dec 26;109:62-67. Epub 2018 Oct 26.

Department of Radiology, Jinshan Hospital, Fudan University, 1508 Longhang Road, Shanghai 201508, China. Electronic address:

Objective: To investigate the magnetic resonance (MR) imaging morphological relationship between adnexal tumors and the ipsilateral ovaries to characterize the origin and malignancy of tumors.

Material And Methods: Clinical and MR imaging data of 496 adnexal tumors confirmed by histology (ovary tumors, n = 400, non-ovarian tumors, n = 96; benign tumors, n = 183, borderline tumors, n = 120, and malignant tumors, n = 193) were retrospectively analyzed. The presence and shape of the ipsilateral ovaries within the context of adnexal tumors of different origins, malignancies and configurations were evaluated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183037
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http://dx.doi.org/10.1016/j.ejrad.2018.10.027DOI Listing
December 2018
11 Reads

Can Presurgical Ultrasound Predict Survival in Women With Ovarian Masses?

Ultrasound Q 2019 Mar;35(1):39-44

Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX.

Purpose: This study aimed to determine the ability of ultrasound to predict survival and detect more aggressive tumors in women with ovarian masses.

Materials And Methods: Institutional review board approval was obtained. A total of 167 patients who presented with adnexal mass/masses were included. Read More

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http://Insights.ovid.com/crossref?an=00013644-900000000-9972
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http://dx.doi.org/10.1097/RUQ.0000000000000401DOI Listing
March 2019
16 Reads

External validation of ADNEX MR SCORING system: a single-centre retrospective study.

Clin Radiol 2019 Feb 1;74(2):131-139. Epub 2018 Dec 1.

Department of Radiology, Faculty of Medicine, Saga University, Saga, 849-8501, Japan.

Aim: To evaluate the accuracy of the ADNEX MR SCORING system for characterising adnexal masses.

Materials And Methods: An institutional review board approved this retrospective study. The study population comprised 663 women who underwent magnetic resonance imaging (MRI) from January 2007 to December 2014 to characterise 778 adnexal masses that were indeterminate under ultrasonography (590 benign and 188 malignant). Read More

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http://dx.doi.org/10.1016/j.crad.2018.10.014DOI Listing
February 2019
3 Reads

An incidental diagnosis of a giant paraovarian cyst in a female teenager: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13406

Department of Pediatrics.

Rationale: Paraovarian cysts (PCs) are cystic tumors that can be encountered between the ovarian hilum and the ovarian fimbria located within the mesosalpinx and broad ligament, being usually diagnosed within the 3rd and 4th decade of life.

Patient Concerns: We report the case of a 15-year-old female admitted in our clinic for consciousness loss, who was incidentally diagnosed with a giant pelvic cystic at ultrasound.

Diagnoses: The magnetic resonance image showed a cystic mass of 170/140/85 mm, suggesting an origin from the left ovary, reaching the subhepatic area. Read More

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http://dx.doi.org/10.1097/MD.0000000000013406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283066PMC
November 2018
10 Reads
5.723 Impact Factor

Cyto-Histopathological Correlation of Skin Adnexal Tumors: A Short Series.

J Cytol 2018 Oct-Dec;35(4):204-207

Department of Pathology, ESI Hospital, New Delhi, India.

Background: Skin adnexal neoplasms are relatively rare and thus uncommonly encountered in routine pathology practice.

Aims: The present study was conducted with the aim to diagnose various skin adnexal tumors on fine-needle aspiration cytology (FNAC) followed by confirmation on histopathology and immunohistochemistry of the excised tumor.

Materials And Methods: A total of 11 cases of superficial nodular swellings of the skin were studied over a period of 2 years from 2015 to 2016. Read More

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http://dx.doi.org/10.4103/JOC.JOC_63_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210812PMC
December 2018
6 Reads

Malignant Sweat Gland Tumors.

Hematol Oncol Clin North Am 2019 Feb;33(1):53-71

Department of Pathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA. Electronic address:

Malignant sweat gland neoplasms are a confusing area within dermatopathology, with many entities reported under several designations in the literature. This review describes the key clinical and histopathologic features of select malignant adnexal neoplasms, including porocarcinoma, papillary carcinoma, adenoid cystic carcinoma, cribriform carcinoma, apocrine hidradenocarcinoma, malignant mixed tumor of the skin, syringoid carcinoma, cylindrocarcinoma, spiradenocarcinoma, mucinous carcinoma, polymorphous sweat gland carcinoma, microcystic adnexal carcinoma, secretory carcinoma of the skin, and primary cutaneous signet ring cell carcinoma. For entities with overlapping features, differential diagnoses are discussed. Read More

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http://dx.doi.org/10.1016/j.hoc.2018.09.002DOI Listing
February 2019
6 Reads

Cross-contamination of pathology specimens: a cautionary tale.

Cutis 2018 Oct;102(4):E12-E14

Departments of Dermatology and Pathology, Stanford Hospital and Clinics, Redwood City, California, USA.

There are many potential sources of error in clinical practice. An astute clinician must not only work hard to prevent errors but also minimize harmful sequelae that could arise from errors that do occur. A rare but real source of error is cross-contamination of pathology specimens. Read More

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October 2018
12 Reads

Concomitant fibrofolliculoma and trichodiscoma on the abdomen.

Cutis 2018 Oct;102(4):E30-E32

Department of Dermatology, Harbor-UCLA Medical Center, Torrance, California, USA.

Fibrofolliculoma and trichodiscoma are adnexal tumors that arise from or around hair follicles and are two of the many characteristic features of Birt-Hogg-Dubé (BHD) syndrome. Fibrofolliculoma and other hair follicle hamartomas can be differentiated from their clinically indistinct counterparts (eg, trichodiscomas, trichoadenomas) by histologic and staining comparison. We report a rare case of a 54-year-old man who presented with a subcutaneous papule on the abdomen that was histologically proven to have features of both a solitary fibrofolliculoma and trichodiscoma. Read More

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October 2018
4 Reads

Prognostic factors and survival outcomes for head and neck cutaneous adnexal cancers.

Am J Otolaryngol 2019 Jan - Feb;40(1):110-114. Epub 2018 Sep 22.

Department of Otorhinolaryngology - Head and Neck Surgery, Rush University Medical Center, Chicago, IL, United States of America.

Objectives: Malignant cutaneous adnexal tumors (MCAT) are rare and comprise a heterogeneous group of cancers. There have been several studies reviewing prognostic factors of these tumors, but no studies focusing on the head and neck. This study aimed to review a large population based database to evaluate prognostic factors that could impact survival. Read More

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http://dx.doi.org/10.1016/j.amjoto.2018.09.011DOI Listing
September 2018
16 Reads

A retrospective study of 2228 cases with eyelid tumors.

Int J Ophthalmol 2018 18;11(11):1835-1841. Epub 2018 Nov 18.

Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, China.

Aim: To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015.

Methods: In this retrospective study, a total of 2228 cases of eyelid tumors with pathologic diagnoses were enrolled. The eyelid tumors were classified into three groups according to tumor origin: epidermal, adnexal and miscellaneous, including melanocytic, neural and vascular lesions. Read More

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http://www.ijo.cn/gjyken/ch/reader/view_abstract.aspx?file_n
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http://dx.doi.org/10.18240/ijo.2018.11.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232338PMC
November 2018
12 Reads

Intraoperative consultation in gynecologic pathology.

Cesk Patol 2018 ;54(3):105-118

Intraoperative consultation represents an integral part of diagnostic protocols in gynecologic oncology. It may be indicated 1) to evaluate the biologic nature of a pathologic process (distinction between nonneoplastic lesions and tumors), 2) to classify the histologic type of tumor and assess its biologic behavior (typing), 3) to confirm or rule out the metastatic origin of a tumor, 4) to determine the degree of differentiation and extent of local spread of a malignant tumor (grading and staging), 5) to detect tumor deposits in lymph nodes, 6) to examine surgical resection margins, 7) to detect products of conception in uterine curettings when ectopic pregnancy is suspected and 8) to collect native tumor tissue for ancillary studies (molecular methods, flow cytometry). A frozen section of adnexal masses is commonly requested and focused primarily on the recognition of malignant tumors, the distinction between borderline tumors and carcinomas, and the identification of a metastatic process in the ovary. Read More

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January 2018
12 Reads

Distinct Biological Types of Ocular Adnexal Sebaceous Carcinoma: HPV-Driven and Virus-Negative Tumors Arise through Nonoverlapping Molecular-Genetic Alterations.

Clin Cancer Res 2019 Feb 12;25(4):1280-1290. Epub 2018 Nov 12.

Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Purpose: Ocular adnexal (OA) sebaceous carcinoma is an aggressive malignancy of the eyelid and ocular adnexa that frequently recurs and metastasizes, and effective therapies beyond surgical excision are lacking. There remains a critical need to define the molecular-genetic drivers of the disease to understand carcinomagenesis and progression and to devise novel treatment strategies.

Experimental Design: We present next-generation sequencing of a targeted panel of cancer-associated genes in 42 and whole transcriptome RNA sequencing from eight OA sebaceous carcinomas from 29 patients. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-1688DOI Listing
February 2019
11 Reads
8.722 Impact Factor

Nonmelanoma Skin Cancer.

Facial Plast Surg Clin North Am 2019 Feb;27(1):1-13

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Schulich School of Medicine, Western University, St Joseph's Hospital, 268 Grosvenor Street 2nd Floor, London, Ontario N6A 4V2, Canada.

This article reviews the most common nonmelanoma skin cancers affecting the head and neck region. Although the most common of these malignancies rarely result in mortality, local morbidity caused by the tumors and their extirpation cannot be underestimated. Complete tumor extirpation with pathologically confirmed negative margins is the gold standard. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10647406183006
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http://dx.doi.org/10.1016/j.fsc.2018.08.001DOI Listing
February 2019
15 Reads

Spontaneous complete regression of large uterine fibroid after the second vaginal delivery: Case report.

Authors:
Myounghwan Kim

Medicine (Baltimore) 2018 Nov;97(45):e13092

Rationale: Fibroids are common, hormone-dependent, benign uterine tumors. It is estimated that they occur in 20% to 40% of women during their reproductive years. The prevalence of fibroids among pregnant women is 10. Read More

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http://Insights.ovid.com/crossref?an=00005792-201811090-0003
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000013092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250539PMC
November 2018
9 Reads

Diagnosis and Treatment of Ovarian Cancer.

Hematol Oncol Clin North Am 2018 12;32(6):943-964

Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, University of Pittsburgh School of Medicine, 300 Halket Street, Pittsburgh, PA 15213, USA. Electronic address:

Epithelial ovarian cancer classically presents with vague persistent gastrointestinal, urologic, or nonacute abdominal/pelvic symptoms (bloating, early satiety, discomfort). Ultimately, a pelvic examination or imaging identifies an adnexal mass typically with accompanied advanced peritoneal dissemination. Management involves aggressive cytoreductive surgery in combination with platinum and taxane chemotherapy. Read More

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http://dx.doi.org/10.1016/j.hoc.2018.07.010DOI Listing
December 2018
4 Reads

Diagnostic value of the gynecology imaging reporting and data system (GI-RADS) with the ovarian malignancy marker CA-125 in preoperative adnexal tumor assessment.

J Ovarian Res 2018 Nov 3;11(1):92. Epub 2018 Nov 3.

Clinical Unit of Obstetrics, Women's Disease and Gynecological Oncology, sw. Jozefa 53/59, United District Hospital, Collegium Medicum University of Nicolaus Copernicus in Toruń, Torun, Poland.

Objectives: The purpose of this study is to assess the preoperative evaluation of an adnexal mass using the GI-RADS classification and to verify whether CA-125 measurement can offer any additional benefits to the GI-RADS-based prediction of ovarian tumor malignancy.

Material And Methods: In this study, we assessed a total of 215 women with an adnexal tumor using the GI-RADS classification combined with CA-125 measurement. All adnexal masses underwent histological verification. Read More

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http://dx.doi.org/10.1186/s13048-018-0465-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215357PMC
November 2018
13 Reads

Epidemiology of Skin Diseases in a Diverse Patient Population.

J Drugs Dermatol 2018 Oct;17(10):1032-1036

Background: Epidemiologic studies of patients who present to dermatology clinics are necessary to identify the needs of patients.

Objective: To quantify and compare diagnoses according to race, ethnicity, and socioeconomic status (SES) at 6 general dermatology clinics from January 2013 to December 2016.

Methods: A retrospective cohort of new patients was established using an electronic medical record database. Read More

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October 2018
11 Reads

Role of proton MR spectroscopy in the differentiation of borderline from malignant epithelial ovarian tumors: A preliminary study.

J Magn Reson Imaging 2018 Oct 24. Epub 2018 Oct 24.

Department of Radiology, Jinshan Hospital, Shanghai Medical College, Fudan University, Shanghai, P.R. China.

Background: Due to the overlapping imaging appearances between borderline and malignant epithelial ovarian tumors (EOTs), borderline EOTs often represent a diagnostic challenge on conventional MRI. Proton magnetic resonance spectroscopy ( H-MRS) might have potential to differentiate borderline from malignant tumors.

Purpose: To investigate the ability of H-MRS to differentiate borderline from malignant EOTs. Read More

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http://doi.wiley.com/10.1002/jmri.26541
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http://dx.doi.org/10.1002/jmri.26541DOI Listing
October 2018
12 Reads

Ocular and Periocular Tumors in Xeroderma Pigmentosum: A Study of 120 Asian Indian Patients.

Am J Ophthalmol 2019 Feb 16;198:146-153. Epub 2018 Oct 16.

Ophthalmic Pathology Laboratory, L. V. Prasad Eye Institute, Hyderabad, India.

Purpose: We studied the incidence, treatment, and outcome of ocular and periocular tumors in patients with xeroderma pigmentosum (XP).

Design: Retrospective case series.

Methods: This single-institution study included 120 patients with XP who underwent intervention with excisional biopsy, enucleation, or orbital exenteration. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183059
Publisher Site
http://dx.doi.org/10.1016/j.ajo.2018.10.011DOI Listing
February 2019
22 Reads

The burden of cutaneous adnexal carcinomas and the risk of associated squamous cell carcinoma: a population-based study.

Br J Dermatol 2019 Mar 26;180(3):565-573. Epub 2018 Dec 26.

Division of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

Background: Recent studies have shown an increasing incidence of cutaneous adnexal carcinomas (CACs).

Objectives: The aim of our study was to evaluate incidence and survival for cases of CACs and investigate their association with other skin neoplasms.

Methods: We conducted a population-based study. Read More

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http://doi.wiley.com/10.1111/bjd.17321
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http://dx.doi.org/10.1111/bjd.17321DOI Listing
March 2019
3 Reads

Five cases of uterine perivascular epithelioid cell tumors (PEComas) and review of literature.

Arch Gynecol Obstet 2019 Jan 13;299(1):185-190. Epub 2018 Oct 13.

Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 419 Fangxie Road, Huangpu District, Shanghai, 200011, People's Republic of China.

Objectives: Perivascular epithelioid cell tumor (PEComa) is a rare condition and the recognition of this condition is limited. Here we report five cases of uterine PEComa to add to the limited understanding of this rare condition.

Methods: Five cases from Obstetrics and Gynecology Hospital of Fudan University were diagnosed as uterine PEComas. Read More

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http://link.springer.com/10.1007/s00404-018-4920-4
Publisher Site
http://dx.doi.org/10.1007/s00404-018-4920-4DOI Listing
January 2019
11 Reads

Prospective Validation of a Standardized Ultrasonography-Based Ovarian Cancer Risk Assessment System.

Obstet Gynecol 2018 Nov;132(5):1101-1111

Division of Gynecologic Oncology, Regional Women's Health, and Regional Imaging, The Permanente Medical Group, Walnut Creek, and the Division of Research, Kaiser Permanente Northern California, Oakland, California.

Objective: To evaluate the performance of a system that standardizes ovarian cancer risk assessment and reporting on ultrasonography.

Methods: We conducted a prospective community-based cohort study of average-risk women undergoing ultrasonography in 2016 using a reporting system that requires adnexal masses to be categorized as 1, 2, 3, or X based on standardized ultrasound criteria including size, presence of solid components, and vascularity assessed by Doppler. With a median follow-up of 18 months, the risk of ovarian cancer or borderline tumor diagnosis for each category was determined. Read More

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http://Insights.ovid.com/crossref?an=00006250-900000000-9790
Publisher Site
http://dx.doi.org/10.1097/AOG.0000000000002939DOI Listing
November 2018
3 Reads

The accuracy of risk malignancy index in prediction of malignancy in women with adnexal mass in Basrah, Iraq.

Niger J Clin Pract 2018 Oct;21(10):1254-1259

Basrah General Health Directorate, Basrah, Iraq.

Background: Adnexal masses indicate a variety of gynecological and nongynecological disorders, which may be benign or malignant. Early detection of malignancy is crucial to a proper planning of treatment and improvement of survival.

Objective: To determine the accuracy of risk of malignancy index (RMI) in prediction of malignant adnexal mass. Read More

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http://dx.doi.org/10.4103/njcp.njcp_424_16DOI Listing
October 2018
3 Reads