5,669 results match your criteria Adnexal Tumors


Incisional carcinoma of Mullerian Origin: A case report and review of literature.

Gynecol Oncol Rep 2020 Aug 22;33:100588. Epub 2020 May 22.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Women's Health, University of Minnesota, Minneapolis, MN, United States.

Primary incisional carcinoma (PIC) is a rare, delayed complication of surgery, usually attributed to the malignant transformation of endometriosis. We report a case of incisional carcinoma with nodal metastases in a 55-year-old woman, 18 years after cesarean section. She underwent extirpative surgery, including hysterectomy and bilateral salpingo-oophorectomy, without intraperitoneal disease identifed. Read More

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http://dx.doi.org/10.1016/j.gore.2020.100588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262414PMC

Magnetic resonance scoring system for the assessment of ovarian and adnexal masses: added value of diffusion-weighted imaging including the apparent diffusion coefficient map.

Ultrasound Obstet Gynecol 2020 May 21. Epub 2020 May 21.

Departments of Radiology, University Hospital Brugmann, Université Libre de Bruxelles, Brussels, Belgium.

Objectives: To prospectively validate the ADNEX magnetic resonance (MR) scoring system and to evaluate a new modified ADNEX MR scoring system including diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) map to assess ovarian and adnexal masses.

Methods: The ethical committee approved this study. Written informed consent was waived. Read More

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http://dx.doi.org/10.1002/uog.22090DOI Listing

YAP1-NUTM1 Gene Fusion in Porocarcinoma of the External Auditory Canal.

Head Neck Pathol 2020 May 20. Epub 2020 May 20.

Institute of Pathology and Molecular Diagnostics, University Hospital, Augsburg, Germany.

Gene fusions involving the NUTM1 gene (NUT) represent defining genetic markers of a highly aggressive carcinoma type with predilection for the midline structures of children and young adults, hence the original description as NUT midline carcinoma. Recent studies have increasingly documented involvement of the NUTM1 gene in the pathogenesis of other entities as well. We herein describe two cases of auditory canal carcinomas with features of porocarcinoma, both harboring a newly described YAP1-NUTM1 gene fusion. Read More

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http://dx.doi.org/10.1007/s12105-020-01173-9DOI Listing

Ovarian carcinoma: pathology review with an emphasis in their molecular characteristics.

Chin Clin Oncol 2020 May 20. Epub 2020 May 20.

Surgical pathology, Instituto Nacional de Cancerología, Mexico City, Mexico.

Ovarian carcinoma is highly aggressive and difficult to treat neoplasm, which is usually detected in advanced stages where most patients recur. Extensive investigation about several treatment modalities has been performed but this neoplasm has poor benefits from such treatments including targeted therapy. Recent data have begun to highlight the histological and molecular heterogeneity of these tumors defining this neoplasm, not as a single disease but a group of heterogeneous histological subtypes with important differences in terms of genetics, morphology, oncogenesis, prognosis, chemosensitivity and especially molecular characteristics that are likely to be targets of new molecules. Read More

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http://dx.doi.org/10.21037/cco-20-31DOI Listing

Palpebral Pleomorphic Adenomas of the Lacrimal Gland.

Ophthalmic Plast Reconstr Surg 2020 May 4. Epub 2020 May 4.

Adnexal Service, Moorfields Eye Hospital, London, United Kingdom.

Aims: To report the characteristics and management for patients with palpebral pleomorphic adenoma of the lacrimal gland.

Methods: The records for patients with palpebral pleomorphic adenoma seen at Moorfields Eye Hospital between 1978 and 2019 were reviewed for demographics, presentation, imaging, histopathology, management, and outcome.

Results: Forty-three patients (25 male; 58%) with palpebral pleomorphic adenoma were identified, presenting at a mean age of 46 years (median 46. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001682DOI Listing

Histopathologic spectrum of paediatric eye and ocular adnexal tumours: A 10-year review from a referral centre in Nigeria.

Niger J Clin Pract 2020 May;23(5):654-659

Department of Pathology, Faculty of Basic Clinical Sciences, College of Health Sciences, Ahmadu Bello University, Zaria, Nigeria.

Background: Tumours of the eye and adnexa demonstrate great histologic variety and constitute a serious threat to vision especially in children.

Aims: The study aims to review the epidemiologic and pathologic characteristics of tumours of the eye and ocular adnexa in the paediatric age group (0-14 years).

Methods: All the cases entered into the departmental records as tumours of the eye and ocular adnexa over a 10-year period in the age group 0-14 years were extracted. Read More

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http://dx.doi.org/10.4103/njcp.njcp_389_19DOI Listing

Morphologically High-Grade Microcystic Adnexal Carcinoma: A report of two cases.

Histopathology 2020 May 2. Epub 2020 May 2.

Department of Dermatopathology, St John's Institute of Dermatology, St Thomas' Hospital, London, England.

Aims: Microcystic adnexal carcinoma is a distinctive sweat duct carcinoma of low-grade malignant potential with risk for locally destructive growth and local recurrence. Distant metastases and disease related mortality is exceptional. The histological hallmarks of these tumours are the diffusely infiltrative growth within dermis, the frequent invasion of subcutaneous structures, the presence of perineurial invasion and the bland cytological features. Read More

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http://dx.doi.org/10.1111/his.14130DOI Listing

Scoring systems for the evaluation of adnexal masses nature: current knowledge and clinical applications.

J Obstet Gynaecol 2020 Apr 29:1-8. Epub 2020 Apr 29.

Obstetrics and Gynecology Unit, Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy.

Adnexal masses are a common finding in women, with 20% of them developing at least one pelvic mass during their lifetime. There are more than 30 different subtypes of adnexal tumours, with multiple different subcategories, and the correct characterisation of the pelvic masses is of paramount importance to guide the correct management. On that basis, different algorithms and scoring systems have been developed to guide the clinical assessment. Read More

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http://dx.doi.org/10.1080/01443615.2020.1732892DOI Listing

Ovarian cysts in pregnancy: a narrative review.

J Obstet Gynaecol 2020 Apr 29:1-7. Epub 2020 Apr 29.

Department of Gynaecology, Royal Women's Hospital, Parkville, Australia.

Most adnexal masses are benign, incidental findings of pregnancy which resolve spontaneously. They may present clinically due to haemorrhage, rupture, torsion and mass effect. Aetiological classification includes ovarian benign, ovarian malignant, non-ovarian, gynaecological, non-ovarian non-gynaecological and an additional subset of pathologies unique to pregnancy. Read More

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http://dx.doi.org/10.1080/01443615.2020.1734781DOI Listing

Endocrine mucin-producing sweat gland carcinoma - newly described skin appendageal tumours.

Malays J Pathol 2020 Apr;42(1):111-114

Universiti Putra Malaysia, Faculty of Medicine and Health Sciences, Department of Pathology, 43400 Serdang, Selangor, Malaysia.

Introduction: Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a recently described adnexal tumour with a predilection for the face particularly the eye-lids. Considered to be a precursor lesion of mucinous adenocarcinoma, it may represent part of a morphological spectrum. We described a case of this entity, which we believe is the first case to be reported in Malaysia. Read More

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Comparison of the predictive performance of risk of malignancy indexes 1-4, HE4 and risk of malignancy algorithm in the triage of adnexal masses.

J Ovarian Res 2020 Apr 25;13(1):46. Epub 2020 Apr 25.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450002, P. R. China.

Objectives: For patients presenting with adnexal mass, it is important to correctly distinguish whether the mass is benign or malignant for the purpose of precise and timely referral and implication of correct line of management. The objective of this study was to evaluate the performance of Risk of malignancy Indexes (RMI) 1-4, Human Epididymis Protein 4 (HE4) and Risk of Malignancy Algorithm (ROMA) in differentiating the adnexal mass into benign and malignant.

Methods: A retrospective study using 155 patients diagnosed with adnexal mass between January 2014 to December 2014 in The First Affiliated Hospital of Zhengzhou University was conducted. Read More

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http://dx.doi.org/10.1186/s13048-020-00643-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183707PMC

Bowen disease with matrical differentiation: report of an exceptional histopathologic presentation.

J Cutan Pathol 2020 Apr 16. Epub 2020 Apr 16.

Dermatopathology Bodensee, Friedrichshafen, Germany.

Matrical differentiation is the distinctive feature of pilomatricoma and other purely matrical adnexal neoplasms; additionally, foci of matrical differentiation have been also described in hybrid cysts of Gardner syndrome, as well as in a wide variety of benign and malignant cutaneous tumors, including basal cell carcinoma. We report an exceptional case of Bowen disease exhibiting multiple foci of matrical differentiation, as confirmed by means of immunohistochemical studies. Several types of divergent, non-squamous differentiation have been exceptionally reported in cutaneous squamous cell carcinoma in situ (cSCCIS), including sebaceous, mucinous/glandular, poroid, tricholemmal, and neuroendocrine differentiation; matrical differentiation may be added to this list. Read More

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http://dx.doi.org/10.1111/cup.13714DOI Listing

Are clinicians successful in diagnosing cutaneous adnexal tumors? a retrospective, clinicopathological study.

Turk J Med Sci 2020 Apr 14. Epub 2020 Apr 14.

Background And Aim: Cutaneous adnexal tumors (CAT) are rare tumors originating from the adnexal epithelial parts of the skin. Due to its clinical and histopathological characteristics comparable with other diseases, clinicians and pathologists experience difficulties in its diagnosis. We aimed to reveal the clinical and histopathological characteristics of the retrospectively screened cases and to compare the pre-diagnoses and histopathological diagnoses of clinicians. Read More

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http://dx.doi.org/10.3906/sag-2002-126DOI Listing

Postmenopausal mild hirsutism and hyperandrogenemia due to ovarian Sertoli-Leydig cell tumor: A case report.

Heliyon 2020 Apr 6;6(4):e03746. Epub 2020 Apr 6.

Department of Pathology, Hubei Provincial Hospital of Integrated Chinese & Western Medicine, Wuhan, China.

Among several types of ovarian tumors, Sertoli-Leydig cell tumors are considered significantly rare, accounting for less than 1% of all primary ovarian tumors. Hirsutism caused by ovarian tumors accounts for approximately 1% of all cases of hirsutism. We report a case of a woman with a ovarian Sertoli-Leydig cell tumor who presented with hirsutism. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139105PMC

Adnexal Masses in Adolescents.

Pediatr Ann 2020 Apr;49(4):e183-e187

Adnexal masses in adolescents, such as functional cysts, are often benign and can usually be managed expectantly since they typically regress on their own. The most common ovarian neoplasm in adolescents is a benign cystic teratoma. Both functional cysts and benign cystic teratomas are associated with ovarian torsion. Read More

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http://dx.doi.org/10.3928/19382359-20200227-01DOI Listing

Gynecologic cancer in pregnancy.

Gynecol Oncol 2020 Apr 5. Epub 2020 Apr 5.

Division of Gynecologic Oncology, University of California, Irvine Medical Center, Orange, CA, USA. Electronic address:

Cancer complicates 1 in 1000 pregnancies. Multidisciplinary consensus comprised of Gynecologic Oncology, Pathology, Neonatology, Radiology, Anesthesiology, Maternal Fetal Medicine, and Social Work should be convened. Pregnancy provides an opportunity for cervical cancer screening, with deliberate delays in treatment permissible for early stage carcinoma. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.03.015DOI Listing

Multiple proliferating pilar tumors with porokeratotic adnexal ostial nevus: A rare association.

JAAD Case Rep 2020 Apr 25;6(4):344-347. Epub 2020 Mar 25.

Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island.

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http://dx.doi.org/10.1016/j.jdcr.2019.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103661PMC

Giant Paratubal Serous Cystadenoma in an Adolescent Female: Case Report and Literature Review.

J Pediatr Adolesc Gynecol 2020 Apr 3. Epub 2020 Apr 3.

College of Medicine, QU Health, Qatar University, Doha, Qatar. Electronic address:

Background: Paraovarian/paratubal cysts constitute 5-20% of all adnexal lesions and typically originate from the paramesonephric or Müllerian duct. The primary epithelial tumors arising from paraovarian cysts account for 25% of the cases, but giant cystadenomas of paraovarian origin are extremely uncommon during childhood and adolescence with very few cases reported in the literature.

Case: We present the case of a 15-year-old female that presented with a bulky mass in the abdomen and pelvis. Read More

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http://dx.doi.org/10.1016/j.jpag.2020.03.010DOI Listing
April 2020
1.812 Impact Factor

Adult-onset porokeratotic eccrine ostial and dermal duct nevus:dermatoscopic findings and treatment with tazarotene.

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

Department of Dermatology, Ed. Herriot Hospital Group, Lyon, France and Department of Pathology, Centre Hospitalier Lyon Sud, Pierre Bénite.

Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is a rare dermatosis initially described as 'comedo nevus' and renamed 'PEODDN'; it has also been referred to as linear eccrine nevus with comedones, porokeratotic eccrine ostial and hair follicle nevus, and porokeratotic adnexal ostial nevus. PEODDN is usually present at birth or develops early in life. Rarely, PEODDN can develop in adults. Read More

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February 2020

Pediatric dermatoses pattern at a Brazilian reference center.

J Pediatr (Rio J) 2020 Mar 26. Epub 2020 Mar 26.

Universidade de São Paulo (USP), Faculdade de Medicina, Departamento de Dermatologia, São Paulo, SP, Brazil.

Objective: The aim of this study was to identify the pattern of pediatric dermatoses of patients evaluated at a dermatologic clinic of a reference center in Brazil and to compare these results to similar surveys conducted in other countries.

Methods: A retrospective study was performed of patients up to 18 years old, evaluated at a dermatologic clinic between January 1, 2017 and December 31, 2017. Variables collected for analysis included age, gender, dermatological diagnosis, multidisciplinary follow-up, hospitalization, and complementary exams. Read More

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http://dx.doi.org/10.1016/j.jped.2020.02.002DOI Listing

Susceptibility-weighted MR sequence for the evaluation of ovarian masses with torsion.

Br J Radiol 2020 May 1;93(1109):20200110. Epub 2020 Apr 1.

Department of Radiology, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, Japan.

Objective: Adnexal torsion is a rare gynecologic emergency caused by twisting of an adnexal mass. Twisted vascular pedicle is the most specific imaging finding for adnexal torsion, however, identification of twisted vascular pedicle can be challenging. The purpose of this study is to evaluate the feasibility of susceptibility-weighted MR sequence (SWS) for the diagnosis of adnexal torsion. Read More

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http://dx.doi.org/10.1259/bjr.20200110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217581PMC

An interesting case of likely related bilateral breast cancer with metastasis in the fimbrial part of fallopian tube.

Hered Cancer Clin Pract 2020 19;18. Epub 2020 Mar 19.

1Division of Medical Oncology, Institute of Oncology Ljubljana, Zaloska cesta 2, 1000 Ljubljana, Slovenia.

Background: In a patient with a germline pathogenic variant with breast cancer, an adnexal mass can represent either a metachronous primary tumor or a metastasis of the breast cancer. A clear distinction between those two possibilities is crucial since treatments differ substantially and so does survival of the patient.

Case Presentation: We present a case of a 47-year-old patient with bilateral breast carcinoma with a germline pathogenic variant. Read More

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http://dx.doi.org/10.1186/s13053-020-00139-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081695PMC

Adnexal Tumor-Related Neurobehavioral Alterations: A Rare Case Report.

Case Rep Obstet Gynecol 2020 25;2020:3802940. Epub 2020 Feb 25.

Department of Gynaecology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Sao Paulo, Brazil.

Associations between neuropsychotic changes and oncologic disease are often described as late-onset symptoms, secondary to the instituted treatment. However, neurocognitive symptoms as a clinical manifestation of adnexal tumors are still little discussed, despite the importance of these in the gynecology practice. In this article, we present a case of adnexal mass whose first clinical manifestations were neuropsychiatric alterations. Read More

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http://dx.doi.org/10.1155/2020/3802940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066408PMC
February 2020

Adnexal masses in pregnancy: an updated review on diagnosis and treatment.

Tumori 2020 Mar 17:300891620909144. Epub 2020 Mar 17.

Department of Maternal and Child Health and Urological Sciences, "Sapienza" University of Rome, Rome, Italy.

Adnexal masses are not common in pregnancy. They are often discovered incidentally during routine ultrasound examinations. In general, 24%-40% of the cases are benign tumors; up to 8% are malignant tumors. Read More

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http://dx.doi.org/10.1177/0300891620909144DOI Listing
March 2020
1.090 Impact Factor

[The pathology of hereditary ovarian tumors].

Ann Pathol 2020 Apr 13;40(2):85-94. Epub 2020 Mar 13.

Institut multisite des hospices civils de Lyon, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre Bénite cedex, France. Electronic address:

About 23% of adnexal tumors are related to a hereditary syndrome, most often hereditary breast and ovarian cancer syndrome or Lynch syndrome, responsible of epithelial tumors. However, the pathologist should be aware of rare hereditary syndromes responsible of non-epithelial ovarian tumors. Ovarian tumors associated with germline mutation of BRCA genes are essentially high-grade serous carcinomas of tubal origin, while those seen in Lynch syndrome are most often endometrioid or clear cell carcinomas. Read More

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http://dx.doi.org/10.1016/j.annpat.2020.02.015DOI Listing

The prevalence of endometrioma and associated malignant transformation in women over 40 years of age.

J Gynecol Obstet Hum Reprod 2020 May 12;49(5):101725. Epub 2020 Mar 12.

Saglik Bilimleri University Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey. Electronic address:

Objective: Endometriosis is an estrogen-dependent chronic disease, which is regarded as a disease of reproductive-aged women. Endometriosis is most frequently diagnosed during reproductive period. We aimed to determine the frequency of endometrioma in women over 40 years of age who were operated for adnexial mass. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101725DOI Listing

PIWIL-2 and piRNAs are regularly expressed in epithelia of the skin and their expression is related to differentiation.

Arch Dermatol Res 2020 Mar 12. Epub 2020 Mar 12.

Department of Dermatology, Medical University of Vienna, Vienna, Austria.

PIWI proteins play multiple roles in germline stem cell maintenance and self-renewal. PIWI-interacting RNAs (piRNAs) associate with PIWI proteins, form effector complexes and maintain genome integrity and function in the regulation of gene expression by epigenetic modifications. Both are involved in cancer development. Read More

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http://dx.doi.org/10.1007/s00403-020-02052-7DOI Listing

[Transitory apocrine hidrocystomatosis of the scrotum].

Ann Dermatol Venereol 2020 May 9;147(5):361-365. Epub 2020 Mar 9.

Service de dermatologie, grand hôpital de Charleroi, rue de Villers 1, 6280 Loverval, Belgique.

Background: Apocrine hidrocystomas are benign cystic tumors that develop from apocrine gland proliferation. In most cases, they are translucent solitary lesions of the face, generally found in the periorbital region, on the scalp or on the neck. More rarely, apocrine hidrocystomas may be multiple and appear on the ears, trunk, shoulders and genital area. Read More

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http://dx.doi.org/10.1016/j.annder.2019.09.610DOI Listing

Malignant cylindroma of the scalp treated with staged perimeter excision: A case report and literature review.

JPRAS Open 2019 Sep 24;21:1-5. Epub 2019 Apr 24.

Department of Plastic and Reconstructive Surgery, Schulich School of Medicine & Dentistry, Western University, Canada.

Malignant cylindroma is a rare and poorly understood cutaneous malignancy. There is a paucity of literature on these lesions, with only a select number of case reports and limited guidelines on management. We present a case of a 60-year old patient with a malignant cylindroma of the scalp treated surgically with staged perimeter excision and summarize our review of the literature with a focus on management of this potentially aggressive disease. Read More

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http://dx.doi.org/10.1016/j.jpra.2019.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061669PMC
September 2019

[Skin cancers in Madagascar: where do we stand?]

Pan Afr Med J 2019 29;34:167. Epub 2019 Nov 29.

Service Dermatologie, Centre Hospitalo-Universitaire Joseph Raseta Befelatanana, Antananarivo, Madagascar.

Introduction: Skin cancers are malignant keratinizing tumors of epidermal, melaninic or adnexal origin. These cancers are still little known. However they affect people living in Madagascar where the amount of sunshine remains very high with an impact that varies depending on the skin type. Read More

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http://dx.doi.org/10.11604/pamj.2019.34.167.19269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046123PMC

The ADNEX model to triage adnexal masses: An external validation study and comparison with the IOTA two-step strategy and subjective assessment by an experienced ultrasound operator.

Eur J Obstet Gynecol Reprod Biol 2020 Apr 14;247:207-211. Epub 2020 Feb 14.

Department of Surgical Sciences, University of Turin -Turin, Italy.

Objectives: The ADNEX (Assessment of Different NEoplasias in the adneXa) model was developed using parameters collected by experienced (level III) ultrasound examiners. Our primary aim was to externally validate the ADNEX model. Then, the discriminatory performance of ADNEX was compared with the two-step strategy and subjective assessment by an experienced ultrasound operator. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.02.022DOI Listing

Poroid Hidradenocarcinoma of the Ankle: Case Report of a Rare Malignant Cutaneous Adnexal Neoplasm.

J Foot Ankle Surg 2020 Mar - Apr;59(2):423-426

Professor, Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD. Electronic address:

Soft-tissue masses on the anterior ankle result from a broad range of underlying processes, often presenting a diagnostic challenge. Appropriate treatment of these tumors can be determined by using a combination of patient history, interpretation of pathologic findings, physical examination, and radiographic appearance. We present a case of an exceptionally rare malignant cutaneous adnexal tumor, highlighting the importance of adherence to fundamental biopsy principles for diagnosing and managing musculoskeletal lesions. Read More

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http://dx.doi.org/10.1053/j.jfas.2019.08.019DOI Listing

Malignant cutaneous tumours of the scalp: always remember to examine the head.

J Eur Acad Dermatol Venereol 2020 Mar 2. Epub 2020 Mar 2.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Around 2% of cutaneous neoplasms arise in the scalp (scalp tumours: STs). They can be classified as primary STs (epithelial, melanocytic and adnexal) or metastatic (from distal tumours or as a spreading from contiguous structures). This anatomic location is usually poorly examined during dermatological consultations, also due to the presence of the hair cover. Read More

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http://dx.doi.org/10.1111/jdv.16330DOI Listing

Adnexal Involvement in Endometrial Cancer: Prognostic Factors and Implications for Ovarian Preservation.

Ann Surg Oncol 2020 Feb 20. Epub 2020 Feb 20.

Department of Gynecologic Oncology, AC Camargo Cancer Center, São Paulo, Brazil.

Purpose: To determine the risk factors related to adnexal involvement in endometrial cancer (EC) and its implications for ovarian preservation in young women.

Methods: We analyzed a series of 802 patients who were treated at AC Camargo Cancer Center from July 1991 to July 2017. Patients who had peritoneal or systemic dissemination (stage IV) were excluded. Read More

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http://dx.doi.org/10.1245/s10434-020-08261-8DOI Listing
February 2020

Twist and shout: magnetic resonance imaging findings in ovarian torsion.

Radiol Bras 2019 Nov-Dec;52(6):397-402

Instituto de Medicina Integral Professor Fernando Figueira, Recife, PE, Brazil.

Adnexal torsion is characterized by partial or complete rotation of the suspensory ligament of the ovary and its corresponding vascular pedicle, resulting in vascular impairment that can culminate in hemorrhagic infarction, as well as necrosis of the ovary and fallopian tube. Because there are myriad causes of acute pelvic pain, the differential diagnosis of ovarian torsion is often challenging. Consequently, radiologists should be familiar with the main imaging findings. Read More

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http://dx.doi.org/10.1590/0100-3984.2018.0079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007053PMC
February 2020

Obstetrics and Gynecology Residents Can Accurately Classify Benign Ovarian Tumors Using the International Ovarian Tumor Analysis Rules.

J Ultrasound Med 2020 Feb 3. Epub 2020 Feb 3.

College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda.

Objectives: Recognition of benign versus malignant tumors is essential in gynecologic ultrasound (US). The International Ovarian Tumor Analysis (IOTA) rules have been proposed as part of resident US training. The objective of this study was to examine whether they could be accurately used by obstetrics and gynecology residents in Rwanda. Read More

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http://dx.doi.org/10.1002/jum.15234DOI Listing
February 2020

High throughput sequencing reveals high specificity of TNFAIP3 mutations in ocular adnexal marginal zone B-cell lymphomas.

Hematol Oncol 2020 Feb 3. Epub 2020 Feb 3.

Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.

The majority of ocular adnexal (OA) lymphomas (OAL) are extranodal marginal zone lymphomas (MZL). First high throughput sequencing (HTS) studies on OA-MZL showed inconsistent results and the distribution of mutations in reactive lymphoid lesions of this anatomic region has not yet been sufficiently addressed. We characterized OAL and lymphoid lesions of the OA by targeted HTS. Read More

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http://dx.doi.org/10.1002/hon.2718DOI Listing
February 2020

[Borderline Ovarian Tumours: CNGOF Guidelines for Clinical Practice - Pregnancy].

Gynecol Obstet Fertil Senol 2020 03 28;48(3):322-329. Epub 2020 Jan 28.

Pôle Mère-Femme, CHU Besançon, 3, boulevard Fleming, 25000 Besançon, France. Electronic address:

Objective: To determine the place of imaging, tumour markers, type of treatment and surgical route, follow-up, delivery mode, and re-staging in case of BOT during pregnancy, in order to provide guidelines.

Method: A systematic bibliographical analysis on BOT during pregnancy was performed through a PUDMED search on articles published from 1990 to 2019 using keywords « borderline ovarian tumour and pregnancy ».

Results: Pelvic ultrasound is the gold standard and first-line examination for the detection and characterization of adnexal masses during pregnancy (grade C). Read More

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http://dx.doi.org/10.1016/j.gofs.2020.01.018DOI Listing

[Borderline Ovarian Tumours: CNGOF Guidelines for Clinical Practice - Imaging].

Gynecol Obstet Fertil Senol 2020 03 28;48(3):260-276. Epub 2020 Jan 28.

Service de radiologie, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France; ISCD, équipe médecine, Sorbonne université, université Paris 06, IUC, 75005 Paris, France. Electronic address:

Objective: To determine the place of imaging and the performance of different imaging techniques (transvaginal ultrasound with or without Doppler, scoring, CT, MRI) to differentiate benign tumour, borderline ovarian tumour (BOT) and malignant ovarian tumor. Differentiate the histological subtypes of BOT (serous, sero-mucinous, mucinous) and prediction in imaging of the possibility of conservative treatment.

Methods: The research was carried out over the last 16 years using the terms "MeSH" based on the query of the Medline® database and supplemented by the review of references contained in the meta-analyzes, systematic reviews and original articles included. Read More

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http://dx.doi.org/10.1016/j.gofs.2020.01.014DOI Listing

The role of infectious agents in cancer of the ocular region.

APMIS 2020 Feb 30;128(2):136-149. Epub 2020 Jan 30.

Eye Pathology Section, Department of Pathology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

The purpose of the study was to investigate the association between infectious agents and the development of cancer in the ocular adnexa. A comprehensive literary study was carried out, reviewing and summarizing previous reports on the topic. A broad range of malignancies of the ocular adnexa are associated with infectious agents. Read More

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http://dx.doi.org/10.1111/apm.13017DOI Listing
February 2020

Angiolymphoid Hyperplasia with Eosinophilia with Clinical Presentation Concerning for Juvenile Temporal Arteritis.

Ocul Oncol Pathol 2020 Jan 28;6(1):25-30. Epub 2019 Jun 28.

Yale Eye Center, Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, Connecticut, USA.

A 20-year-old boy presented with a mass superotemporal to the right eyebrow of 1 month's duration without a history of recent trauma. Complete examination and workup, including laboratory analysis, Doppler ultrasound imaging, and magnetic resonance imaging, suggested a diagnosis of juvenile temporal arteritis. Excisional biopsy and histopathology contradicted the preoperative workup and yielded the final diagnosis of angiolymphoid hyperplasia with eosinophilia, a rare eosinophilic dermatosis of unknown etiology. Read More

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http://dx.doi.org/10.1159/000500361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984143PMC
January 2020

Apocrine Hidradenoma and Adenomyoepithelioma: Entities on a Biological Continuum of Adnexal Neoplasia.

Am J Dermatopathol 2020 Jan 21. Epub 2020 Jan 21.

Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority, Central Zone, Halifax, Nova Scotia, Canada.

Apocrine hidradenomas (AH) once believed to harbor myoepithelial cells are now considered pure epithelial neoplasms. They are categorized separately from adenomyoepitheliomas which consist of apocrine epithelial and myoepithelial components. Reports of myoepithelial tumors arising in AH have suggested a link between the 2. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001605DOI Listing
January 2020

Clinical and pathological features of women with adnexal masses admitted as emergency cases to the Gynaecology Department of West Kazakhstan University.

Prz Menopauzalny 2019 Dec 4;18(3):180-183. Epub 2019 Dec 4.

Department of Normal and Topographical Anatomy, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.

Aim Of The Study: To detect the clinical and pathological features of women with adnexal masses (AMs) admitted as emergency cases to the Gynaecology Department of West Kazakhstan University.

Material And Methods: A retrospective analysis of the data of women with AMs admitted as an emergency cases to the Gynaecology Department of West Kazakhstan University. The collected data include: age, age of menarche and age of menopause, presenting symptoms, admission criteria - either self-referral or refereed from another department, ultrasound findings, associated pregnancy, associated pathology of the female genital tract, and post-operative histological results of surgically excised AMs (gold standard). Read More

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http://dx.doi.org/10.5114/pm.2019.90377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970418PMC
December 2019
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Evaluation of adnexal tumours in the International Ovarian Tumor Analysis system in reference to histopathological results.

Prz Menopauzalny 2019 Dec 20;18(3):141-145. Epub 2019 Dec 20.

1 Department of Gynaecology and Obstetrics, Clinic of Surgical and Oncological Gynecology, M. Pirogow's Teaching Hospital, Medical University of Lodz, Lodz, Poland.

Aim Of The Study: To retrospectively evaluate how the International Ovarian Tumor Analysis (IOTA) simple rules used in ultrasound examinations estimate the probability of malignant and benign tumour occurrence in the studied population.

Material And Methods: The study was performed on a group of 425 patients with ovarian tumours operated in the Clinic of Surgical and Oncological Gynecology at the Medical University of Lodz in the years 2014-2015. Adnexal tumours were rated according to IOTA simple rules, classifying them as probably malignant, probably benign, or unclassified. Read More

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http://dx.doi.org/10.5114/pm.2019.90812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970421PMC
December 2019

Imaging in gynecological disease: clinical and ultrasound characteristics of adnexal torsion.

Ultrasound Obstet Gynecol 2020 Jan 24. Epub 2020 Jan 24.

Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Roma, Italia.

Objective: To describe the clinical and ultrasound characteristics of adnexal torsion.

Methods: This is a retrospective study. From the operative records of the eight participating gynecological ultrasound centers, we identified patients with a surgically confirmed diagnosis of adnexal torsion (surgical evidence of twisted ovarian pedicle and/or twisted paraovarian cyst and/or tube on its own axis), who had undergone preoperative ultrasound examination by an experienced ultrasound examiner between 2008 and 2018. Read More

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http://dx.doi.org/10.1002/uog.21981DOI Listing
January 2020

Increased Diagnostic Accuracy of Adnexal Tumors with A Combination of Established Algorithms and Biomarkers.

J Clin Med 2020 Jan 21;9(2). Epub 2020 Jan 21.

Department of Obstetrics and Gynecology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.

Ovarian cancer is the most lethal gynecologic cancer. Pre-diagnostic testing lacks sensitivity and specificity, and surgery is often the only way to secure the diagnosis. Exploring new biomarkers is of great importance, but the rationale of combining validated well-established biomarkers and algorithms could be a more effective way forward. Read More

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http://dx.doi.org/10.3390/jcm9020299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073859PMC
January 2020

Desmoplastic Trichoepithelioma: An Uncommon but Diagnostically Problematic Benign Adnexal Tumor.

Acta Dermatovenerol Croat 2019 Dec;27(4):282-284

Vladimír Bartoš, MD, PhD, MPH, Deapartment of Pathology Faculty Hospital in Žilina, Vojtecha Spanyola 43, 012 07 Žilina, Slovakia;

Dear Editor, I read an interesting recent article by Karimzadeh et al. (1) in an earlier issue of your journal, who provided a comprehensive review addressing a relatively rare benign tumor originating from the hair follicles - trichoepithelioma (TE). They rightly claimed that trichoepithelioma can be divided into the following 3 subgroups: a) multiple familiar TE, b) solitary non-hereditary TE, and c) desmoplastic trichoepithelioma (DTE). Read More

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December 2019

FOLLICLE-STIMULATING HORMONE-PRODUCING PITUITARY ADENOMA: A CASE REPORT AND REVIEW OF THE LITERATURE.

AACE Clin Case Rep 2019 May-Jun;5(3):e175-e180. Epub 2019 Apr 25.

Objective: To describe an unusual presentation of a follicle-stimulating hormone-secreting pituitary adenoma leading to ovarian hyperstimulation syndrome. We also discuss the pathophysiology and subsequent management of these tumors.

Methods: This is a case report and review of the literature. Read More

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http://dx.doi.org/10.4158/ACCR-2018-0454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876947PMC

Whole-exome sequencing for ocular adnexal sebaceous carcinoma suggests PCDH15 as a novel mutation associated with metastasis.

Mod Pathol 2020 Jan 14. Epub 2020 Jan 14.

Orbital Oncology & Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1488, Houston, TX, 77030, USA.

Ocular adnexal sebaceous carcinoma (OASeC) is an aggressive eyelid carcinoma. Analysis of molecular-genetic drivers of this disease could reveal new prognostic markers and actionable targets for treatment. To identify somatically acquired genomic mutations in OASeC and explore their associations with metastasis, whole-exome sequencing on DNA extracted from retrospectively collected tumor samples was performed. Read More

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http://dx.doi.org/10.1038/s41379-020-0454-yDOI Listing
January 2020

Ovarian endometrioid adenocarcinoma a with yolk sac tumor in a 41-year-old woman: a case report.

Int J Clin Exp Pathol 2019 1;12(9):3549-3554. Epub 2019 Sep 1.

Department of Pathology, West China Second University Hospital, Sichuan University Chengdu, Sichuan, China.

Background: Yolk sac tumors (YSTs) are the second most common germ cell malignancy of the ovaries generally present in children and young women. YSTs arising in combination with epithelial ovarian carcinoma (EOC) in older women are rarely reported. The YST components in such cases often show a marked morphological and immunophenotypic overlap with epithelial neoplasms, making diagnosis difficult. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949845PMC
September 2019