3,571,028 results match your criteria Administration & Society[Journal]


Effects of Ultra-Low-Dose Aspirin in Thrombosis and Haemorrhage.

Homeopathy 2019 Apr 20. Epub 2019 Apr 20.

Laboratoire d'Hématologie, UFR des Sciences Pharmaceutiques, Université de Bordeaux, Bordeaux, France.

Background:  Aspirin is the oldest and possibly the most widely used pharmacologically active substance still used in allopathic medicine. Its effect on fever and inflammation has paved the way to its anti-thrombotic effect. Dilutions of aspirin have been tested for many years in the University of Bordeaux, in humans as well as in animal models. Read More

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http://dx.doi.org/10.1055/s-0038-1677495DOI Listing

Extracellular vesicles derived from bone marrow mesenchymal stem cells attenuate dextran sodium sulfate-induced ulcerative colitis by promoting M2 macrophage polarization.

Int Immunopharmacol 2019 Apr 17;72:264-274. Epub 2019 Apr 17.

Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei, China. Electronic address:

Extracellular vesicles (EVs) secreted by bone marrow mesenchymal stem cells (BMSCs) have shown repairing effects in tissue damage. However, their efficacy and mechanism in the treatment of ulcerative colitis (UC), a type of chronic inflammatory bowel disease, are unclear. To investigate the effects and possible mechanism of EVs in UC treatment, we established an in vitro model using lipopolysaccharide (LPS)-treated macrophages and an in vivo dextran sulfate sodium (DSS)-induced mouse model to mimic UC. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.020DOI Listing

Mechanochemical esterification of waste mulberry wood by wet Ball-milling with tetrabutylammonium fluoride.

Bioresour Technol 2019 Apr 16;285:121354. Epub 2019 Apr 16.

Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Key Lab of Biomass Energy and Material, Jiangsu Province, National Engineering Lab for Biomass Chemical Utilization, Key Lab on Forest Chemical Engineering, State Forestry Administration, Nanjing 210042, PR China. Electronic address:

Esterification of lignocellulosic biomass driven by dry ball-milling suffered from agglomeration of lignocellulosic matters during milling process. In this study, esterification of waste mulberry wood (MW) was carried out by wet ball-milling with water and tetrabutylammonium fluoride (TBAF) to prepare all-wood-plastic composites. Under the same condition, the esterification of MW by wet ball-milling with TBAF presented higher efficiency than that without TBAF which was attributed to catalytic function of F ions meanwhile the binding of TBA to cellulose fibrils hindered the compaction of fibrillated fragments. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.121354DOI Listing

Personal exposure to black carbon in Stockholm, using different intra-urban transport modes.

Sci Total Environ 2019 Apr 11;674:279-287. Epub 2019 Apr 11.

Environment and Health Administration, Stockholm, Sweden; Department of Environmental Science and Analytical Chemistry, Stockholm University, Stockholm, Sweden.

The traffic microenvironment has been shown to be a major contributor to the total personal exposure of black carbon (BC), and is key to local actions aiming at reducing health risks associated with such exposure. The main aim of the study was to get a better understanding of the determinants of traffic-related personal exposure to BC in an urban environment. Personal exposure to ambient levels of BC was monitored while walking, cycling and traveling by bus or car along four streets and while cycling alternative routes simultaneously. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.100DOI Listing

Five-year observation of aerosol optical properties and its radiative effects to planetary boundary layer during air pollution episodes in North China: Intercomparison of a plain site and a mountainous site in Beijing.

Sci Total Environ 2019 Mar 31;674:140-158. Epub 2019 Mar 31.

State Key Laboratory of Severe Weather (LASW) and Institute of Atmospheric Composition, Chinese Academy of Meteorological Sciences, CMA, Beijing 100081, China.

The aerosol microphysical, optical and radiative properties of the whole column and upper planetary boundary layer (PBL) were investigated during 2013 to 2018 based on long-term sun-photometer observations at a surface site (~106 m a.s.l. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.418DOI Listing

Zhixiong Capsule (ZXC), a traditional Chinese patent medicine, prevents atherosclerotic plaque formation in rabbit carotid artery and the related mechanism investigation based on network pharmacology and biological research.

Phytomedicine 2018 Dec 7;59:152776. Epub 2018 Dec 7.

School of Traditional Chinese Material, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Background And Aims: Chinese patent medicine Zhixiong Capsule (ZXC) has been used in clinical treatment against blood stasis-induced dizziness and headache for many years in China.

Hypothesis/purpose: Recent clinical observations demonstrated a good efficacy of ZXC against atherosclerotic plaque formation in carotid arteries. The aims of this study were to verify the plaque-preventing efficacy of ZXC in animals and to investigate the underlying mechanisms. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.11.036DOI Listing
December 2018

Emodin improves glucose metabolism by targeting microRNA-20b in insulin-resistant skeletal muscle.

Phytomedicine 2018 Nov 16;59:152758. Epub 2018 Nov 16.

Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin 150081, China; Department of Pharmacology and Therapeutics, Melbourne School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, the University of Melbourne, Melbourne, 3010, Australia. Electronic address:

Background: Emerging evidence has indicated the therapeutic potential of emodin with its multiple pharmacological effects.

Purpose: To evaluate role of emodin in regulating insulin resistance (IR) and to elucidate the underlying molecular mechanisms.

Study Design/methods: Fasting blood glucose (FBG) and lipid levels were measured before and after intragastric administration of emodin in type 2 diabetes mellitus (T2DM) rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09447113183057
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http://dx.doi.org/10.1016/j.phymed.2018.11.018DOI Listing
November 2018
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Pharmacokinetic properties of phytochemicals in Hypericum perforatum influence efficacy of regulating oxidative stress.

Phytomedicine 2018 Nov 19;59:152763. Epub 2018 Nov 19.

Nutrifield, Sunshine West, VIC 3020, Australia. Electronic address:

Background: Hypericum perforatum is used in ethnopharmacology and has recently become popular in conventional medicine for treatment of mild to moderate depression. The abundance of potentially functional phytochemicals and their broader utilizations in traditional medicine suggests that ingestion of H. perforatum may impart additional secondary health benefits. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09447113183058
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http://dx.doi.org/10.1016/j.phymed.2018.11.023DOI Listing
November 2018
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Phosphodiesterase-4 Inhibitor Roflumilast Attenuates Pulmonary Air Emboli-Induced Lung Injury.

J Surg Res 2019 Apr 17;241:24-30. Epub 2019 Apr 17.

Division of Pulmonary Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, School of Medicine, Tzu-Chi University, Hualien, Taiwan. Electronic address:

Background: Pulmonary air embolism (PAE)-induced acute lung injury (ALI) can be caused by massive air entry into the lung circulation. PAE can occur during diving, aviation, and some iatrogenic invasive procedures. PAE-induced ALI presents with severe inflammation, hypoxia, and pulmonary hypertension, and it is a serious complication resulting in significant morbidity and mortality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193014
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http://dx.doi.org/10.1016/j.jss.2019.03.028DOI Listing
April 2019
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Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier.

Acta Biomater 2019 Apr 17. Epub 2019 Apr 17.

HIPS - Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research (HZI), Saarland University, Universitätscampus E8.1, 66123 Saarbrücken, Germany; Department of Pharmacy, Saarland University, 66123, Saarbrücken, Germany. Electronic address:

Predictive in vitro models are valuable alternatives to animal experiments for evaluating the transport of molecules and (nano)particles across biological barriers. In this work, an improved triple co-culture of air-blood barrier was set-up, being exclusively constituted by human cell lines that allowed to perform experiments at air-liquid interface. Epithelial NCI-H441 cells and endothelial HPMEC-ST1. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.037DOI Listing

Effectiveness of shortened time interval to postpartum visit in improving postpartum attendance: Design and rationale for a randomized controlled trial.

Contemp Clin Trials 2019 Apr 17. Epub 2019 Apr 17.

The University of Vermont College of Medicine, Division of Reproductive Endocrinology & Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Smith 410, Main Campus, 111, Colchester, Avenue Burlington, VT 05401, USA.

Background/aims: Recent evidence suggests that there are numerous benefits to scheduling postpartum visits as early as 3 weeks post-delivery. However, findings are not conclusive due to methodological limitations. This report discusses the unique aspects of a randomized controlled trial's (RCT) design, intervention, and strategies to maintain participant retention. Read More

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http://dx.doi.org/10.1016/j.cct.2019.04.012DOI Listing

Severe Herpes Zoster Requiring Intravenous Antiviral Treatment in Allogeneic Hematopoietic-cell Transplantation Recipients on Standard Acyclovir Prophylaxis.

Biol Blood Marrow Transplant 2019 Apr 17. Epub 2019 Apr 17.

Brigham and Women's Hospital, Department of Infectious Diseases, Boston, Massachusetts; Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, Massachusetts.

Allogeneic hematopoietic cell transplant (HCT) recipients are at increased risk for varicella zoster virus reactivation and associated complications. The incidence, timing, and risk factors for severe herpes zoster (HZ) are not well described in the era of acyclovir (ACV) prophylaxis. We performed a retrospective cohort study of all patients who underwent first allogeneic HCT from October 2006 to December 2015 at our institution. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.015DOI Listing

Proconvulsant effects of sildenafil citrate on pilocarpine-induced seizures: involvement of cholinergic, nitrergic and pro-oxidant mechanisms.

Brain Res Bull 2019 Apr 17. Epub 2019 Apr 17.

Neuropsychopharmacology Laboratory, Drug Research and Development Center, Faculty of Medicine, Department of Physiology and Pharmacology, Universidade Federal do Ceará, Fortaleza, CE, Brazil; Pharmacy Department, Faculty of Dentistry, Nursing and Pharmacy, Universidade Federal do Ceará, Fortaleza, CE, Brazil. Electronic address:

Sildenafil is a phosphodiesterase 5 inhibitor used for the treatment of erectile dysfunction and pulmonary hypertension. Proconvulsant effect is a serious adverse event associated with sildenafil use. Here, we investigated the possible proconvulsant effects of sildenafil in pilocarpine (PILO)-induced seizures model, which mimics some aspects of temporal lobe epilepsy. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.008DOI Listing

Immunization of mice by the co-administration of codon-optimized HPV16 E7 and lL12 genes against HPV16-associated cervical cancer.

Microb Pathog 2019 Apr 17. Epub 2019 Apr 17.

Infectious Disease Research Center, Golestan University of Medical Sciences, Gorgan, Iran; Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. Electronic address:

Background: Various promising procedures have been used to improve the potency of DNA vaccines for the treatment of human papillomavirus type 16 (HPV16) infections. Interleukin-12 (IL12) is a powerful adjuvant that can contribute to T cell-mediated protection against many pathogens, specifically viruses. Considering the important role of T cell-mediated immunity in tumor clearance, the induction of these responses can help control the progression of tumors in animal models. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.028DOI Listing

Low dose of carvacrol prevents rat pancreas tissue damage after L-arginine application, while higher doses cause pancreatic tissue impairment.

Food Chem Toxicol 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemistry, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000, Niš, Serbia.

Carvacrol (5-isopropyl-2-methylphenol) is a biologically active monoterpene phenol abundantly present in the essential oils of many Lamiaceae aromatic/ethnomedicinal plants. Herein, we aimed to evaluate the damaging effect of carvacrol to rat pancreatic tissue, but also to assess its possible ameliorative impact on pancreatic damage induced by L-arginine. The toxic and beneficial (in a dose of 10 mg/kg) properties of carvacrol were assessed by measuring serum α-amylase and lipase activities, tissue malondialdehyde (MDA) content, and pathohistological changes in pancreatic tissue. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915193020
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http://dx.doi.org/10.1016/j.fct.2019.04.010DOI Listing
April 2019
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Acupuncture reduces nicotine-induced norepinephrine release in the hypothalamus via the solitary NMDA receptor/NOS pathway.

Neurosci Lett 2019 Apr 17. Epub 2019 Apr 17.

Department of Psychopharmacology, Qiqihar Medical University, Qiqihar, 161006, China; MRC-GHF, College of Korean Medicine, Daegu Haany University, Gyeongsan, 38610, Republic of Korea. Electronic address:

Noradrenergic projections from the nucleus tractus solitarius (NTS) to the hypothalamic paraventricular nucleus (PVN) are involved in nicotine (Nic) dependence. Nic induces hypothalamic norepinephrine (NE) release through N-methyl-D-aspartate receptors (NMDARs) and nitric oxide in the NTS. However, acupuncture attenuates Nic withdrawal-induced anxiety. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043940193027
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http://dx.doi.org/10.1016/j.neulet.2019.04.036DOI Listing
April 2019
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Whole genome sequencing and genome annotation of the wild edible mushroom, Russula griseocarnosa.

Genomics 2019 Apr 17. Epub 2019 Apr 17.

Key Laboratory of State Forestry Administration on Tropical Forestry Research, Research Institute of Tropical Forestry, Chinese Academy of Forestry, Guangzhou 510520, China.

Russula griseocarnosa is a species of edible ectomycorrhizal fungi with medicinal properties that grows in southern China. Total DNA was isolated from a fresh fruiting body of R. griseocarnosa and subjected to sequencing using Illumina Hiseq with the PacBio RS sequencing platform. Read More

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http://dx.doi.org/10.1016/j.ygeno.2019.04.012DOI Listing
April 2019
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Screening of novel drugs for inhibiting hepatitis E virus replication.

J Virol Methods 2019 Apr 17. Epub 2019 Apr 17.

Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke-Shi, Tochigi 329-0498, Japan. Electronic address:

Hepatitis E, which is caused by hepatitis E virus (HEV), is generally a self-limiting, acute, and rarely fatal disease. It is sometimes fulminant and lethal, especially during pregnancy. Indeed, it occasionally takes a chronic course in immunocompromised individuals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01660934183029
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http://dx.doi.org/10.1016/j.jviromet.2019.04.017DOI Listing
April 2019
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Astragaloside IV exerts angiogenesis and cardioprotection after myocardial infarction via regulating PTEN/PI3K/Akt signaling pathway.

Life Sci 2019 Apr 17. Epub 2019 Apr 17.

Jiangsu Province Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. Electronic address:

Aims And Methods: Acute myocardial infarction (AMI) is a common cardiovascular disease with high mortality. Astragaloside IV (AS-IV) was reported to have cardioprotective effect after AMI. We hypothesize that the cardioprotective role of AS-IV is exerted by enhancing angiogenesis via regulating PTEN/PI3K/Akt signaling pathway. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.040DOI Listing
April 2019
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Cocaine-induced behavioral sensitization is greater in adolescent than in adult mice and heightens cocaine-induced conditioned place preference in adolescents.

Pharmacol Biochem Behav 2019 Apr 17. Epub 2019 Apr 17.

Instituto de Investigaciones Médicas Mercedes y Martín Ferreyra, INIMEC-CONICET-Universidad Nacional de Córdoba, Argentina. Electronic address:

Adolescents are more sensitive than adults to the neural and behavioral effects of psychostimulants, and exhibit greater vulnerability to drug abuse, dependence or relapse into these conditions. We have reported that cocaine pretreatment during adolescence promotes the expression of behavioral sensitization to a greater extent than when the pretreatment occurs at adulthood. Behavioral sensitization has been associated to the transition from drug use to addiction and is postulated to indicate heightened sensitivity to the appetitive motivational effects of drugs. Read More

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http://dx.doi.org/10.1016/j.pbb.2019.04.005DOI Listing

6-Gingerol abates benzo[a]pyrene-induced colonic injury via suppression of oxido-inflammatory stress responses in BALB/c mice.

Chem Biol Interact 2019 Apr 17. Epub 2019 Apr 17.

Drug Metabolism & Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria. Electronic address:

Exposure to benzo[a]pyrene (BaP), the most toxic polycyclic aromatic hydrocarbon and a procarcinogen, is a global health concern which necessitates preventive measures [6].-Gingerol (6-G), the most pharmacologically active constituent of ginger has been reported to promote gut health in various experimental settings. This study investigated the role of 6-G in BaP-induced colonic oxidative and inflammatory stress responses in mice. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.026DOI Listing

A comparative study of viscoelastic hemostatic assays and conventional coagulation tests in trauma patients receiving fibrinogen concentrate.

Clin Chim Acta 2019 Apr 17. Epub 2019 Apr 17.

Royal Canadian Medical Services, Ottawa, ON, Canada; McGill University, Montreal, QC, Canada.

Background: Both thrombelastography (TEG) and rotational thromboelastometry (ROTEM) have been investigated for diagnosis of coagulopathy and guidance of resuscitation in trauma and surgery. Given similarities between the two systems, it is important to determine whether one is superior to the other and how comparable they are to conventional coagulation tests (CCTs). Therefore, we conducted a comparative study of functional fibrinogen and coagulation assays using TEG and ROTEM and CCTs to determine their capability to monitor coagulation profiles, diagnose coagulopathy and predict blood transfusion requirements in trauma patients. Read More

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http://dx.doi.org/10.1016/j.cca.2019.04.066DOI Listing

Semicarbazone derivatives as promising therapeutic alternatives in leishmaniasis.

Exp Parasitol 2019 Apr 17. Epub 2019 Apr 17.

Laboratório de Farmacologia e Imunologia- Universidade Federal de Alagoas, Laboratório de Farmacologia e Imunidade, Instituto de Ciências Biológicas e da Saúde, Av. Lourival Melo Mota, s/n, Tabuleiro do Martins, CEP:57072-900, Maceió - AL, Brazil; Instituto Nacional de Ciência e Tecnologia de Fármacos e Medicamentos (INCT-INOFAR)(3). Universidade Federal do Rio de Janeiro, Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio(®))(4) CCS, Cidade Universitária, P.O. Box 68024, ZIP, 21941-971, Rio de Janeiro-RJ, Brazil. Electronic address:

In the present study, we investigated the in vitro and in vivo leishmanicidal activity of synthetic compounds, containing a semicarbazone scaffold as a peptide mimetic framework. The leishmanicidal effect against amastigotes of Leishmania amazonensis was also evaluated at concentration of 100 μM-0.01 nM. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144894183038
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http://dx.doi.org/10.1016/j.exppara.2019.04.003DOI Listing
April 2019
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Different routes and formulations of melatonin in critically-ill patients. A pharmacokinetic randomized study.

Clin Endocrinol (Oxf) 2019 Apr 20. Epub 2019 Apr 20.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy.

Background And Objectives: Critically-ill patients present reduced endogenous melatonin blood levels, and they might benefit from its exogenous supplementation. The aim of this research was to evaluate the feasibility of different routes of administration and drug formulations of melatonin. The efficiency of absorption was assessed as well as the adequacy in achieving and maintaining the physiological nocturnal blood peak. Read More

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http://dx.doi.org/10.1111/cen.13993DOI Listing

Influence of rifampin-mediated OATP1B1/1B3 inhibition on the pharmacokinetics of clazosentan.

Clin Transl Sci 2019 Apr 20. Epub 2019 Apr 20.

Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.

Clazosentan is a selective endothelin A receptor antagonist in development for prevention and treatment of vasospasm post subarachnoid hemorrhage. It is a substrate of organic-anion-transporting polypeptide (OATP)1B1/1B3 based on preclinical data. This randomized, double-blind, two-period cross-over study investigated the pharmacokinetics, safety, and tolerability of an intravenous (i. Read More

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http://dx.doi.org/10.1111/cts.12639DOI Listing

Scopolamine Toxicity in an Elderly Patient.

Mil Med 2019 Apr 20. Epub 2019 Apr 20.

Department of Anesthesia, Brooke Army Medical Center, 3551 Rodger Brooke Dr, Ft Sam Houston, TX 78234.

We present a case of a 66-year-old female who was to undergo a scheduled operation and placed on our institution's ERAS (Enhanced Recovery After Surgery) protocol. The intraoperative course was unremarkable. The patient developed delayed emergence in the Post-Anesthesia Care Unit. Read More

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http://dx.doi.org/10.1093/milmed/usz086DOI Listing

Optimal Scheduling of Bevacizumab and Pemetrexed/cisplatin Dosing in Non-Small Cell Lung Cancer.

CPT Pharmacometrics Syst Pharmacol 2019 Apr 19. Epub 2019 Apr 19.

Iowa State University College of Veterinary Medicine, Ames, IA, U.S.A.

Bevacizumab-pemetrexed/cisplatin (BEV-PEM/CIS) is a first line therapeutic for advanced non-squamous non-small cell lung cancer (NSCLC). Bevacizumab potentiates PEM/CIS cytotoxicity by inducing transient tumor vasculature normalization. BEV-PEM/CIS has a narrow therapeutic window. Read More

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http://dx.doi.org/10.1002/psp4.12415DOI Listing
April 2019
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First-in-man study of ACT-709478, a novel selective triple T-type calcium channel blocker.

Epilepsia 2019 Apr 20. Epub 2019 Apr 20.

Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.

Objective: Increased activity of T-type Ca channels is linked to idiopathic generalized epilepsies, thus blocking these channels may be a new treatment option. ACT-709478 is an orally available triple T-type Ca channel blocker. The aim of this first-in-man study was to investigate the pharmacokinetics, pharmacodynamics, tolerability, and safety of single doses of ACT-709478 in healthy subjects. Read More

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http://dx.doi.org/10.1111/epi.14732DOI Listing

Evaluation of cardiovascular risk by growth-differentiation factor-15 and tissue Doppler imaging in children with subclinical hypothyroidism.

Endocrine 2019 Apr 19. Epub 2019 Apr 19.

Department of Biochemistry, Konya Training and Research Hospital, Konya, Turkey.

Objective: Subclinical hypothyroidism, defined as increased TSH serum levels and normal serum free T4 concentrations, has been associated with an increased risk of heart disease in adults. But, data in children and adolescents are scanty and treatment of subclinical hypothyroidism is controversial. Growth differentiation factor-15 (GDF-15) is a promising biomarker of cardiac remodeling. Read More

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http://dx.doi.org/10.1007/s12020-019-01933-wDOI Listing

Economic Evaluation of Sarilumab in the Treatment of Adult Patients with Moderately-to-Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Conventional Synthetic Disease-Modifying Antirheumatic Drugs.

Adv Ther 2019 Apr 19. Epub 2019 Apr 19.

University of Nebraska Medical Center, Omaha, NE, USA.

Introduction: Assess the cost-effectiveness (US healthcare payer perspective) of sarilumab subcutaneous (SC) 200 mg + methotrexate versus conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) or targeted DMARD + methotrexate for moderate-to-severe rheumatoid arthritis (RA) in adults with inadequate response to methotrexate.

Methods: Microsimulation based on patient profiles from MOBILITY (NCT01061736) was conducted via a 6-month decision tree and lifetime Markov model with 6-monthly cycles. Treatment response at 6 months was informed by a network meta-analysis and based on American College of Rheumatology (ACR) response. Read More

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http://dx.doi.org/10.1007/s12325-019-00946-1DOI Listing

Cognitive behavioral therapy for primary care depression and anxiety: a secondary meta-analytic review using robust variance estimation in meta-regression.

J Behav Med 2019 Apr 19. Epub 2019 Apr 19.

Department of Sociology and Social Work, Shanghai Normal University, Shanghai, China.

Cognitive-behavioral therapy (CBT) is well supported for treating depressive and anxiety disorders. Trials of CBT for anxiety and depression in primary care have increased over the past decade, yet only one meta-analysis, published in 2015, examined this topic and the scope of that review is relatively narrow. This study conducted a systematic review and meta-analysis of primary care based CBT for depression and anxiety. Read More

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http://dx.doi.org/10.1007/s10865-019-00046-zDOI Listing

Effects of Fatty Acid Amide Hydrolase Inhibitors Acute Administration on the Positive and Cognitive Symptoms of Schizophrenia in Mice.

Mol Neurobiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodzki 4a Street, 20-093, Lublin, Poland.

The connection between the endocannabinoid system (ECS) and schizophrenia is supported by a large body of research. The ECS is composed of two types cannabinoid (CB: CB1 and CB2) receptors and their endogenous ligands, endocannabinoids. The best-known endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), are intracellularly degraded by fatty acid hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively. Read More

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http://dx.doi.org/10.1007/s12035-019-1596-0DOI Listing

Nanoliposome-encapsulated ellagic acid prevents cyclophosphamide-induced rat liver damage.

Mol Cell Biochem 2019 Apr 19. Epub 2019 Apr 19.

Department of Physiology, Faculty of Medicine, University of Nis, Bulevar Zorana Ðinđića 81, Niš, 18000, Serbia.

In this study, we aimed to evaluate whether the encapsulation of ellagic acid (EA) into nanoliposomes would improve its potential in preventing cyclophosphamide-induced liver damage. Stability and antioxidative potential of free and encapsulated EA were determined. Experimental study conducted in vivo included ten groups of rats treated with cyclophosphamide and ellagic acid in its free and encapsulated form during 5 days. Read More

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http://link.springer.com/10.1007/s11010-019-03541-8
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http://dx.doi.org/10.1007/s11010-019-03541-8DOI Listing
April 2019
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Repetitive transcranial magnetic stimulation protects mice against 6-OHDA-induced Parkinson's disease symptoms by regulating brain amyloid β level.

Mol Cell Biochem 2019 Apr 19. Epub 2019 Apr 19.

Department of Rehabilitation, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang, 110004, People's Republic of China.

Repetitive transcranial magnetic stimulation (rTMS) is a technique protecting neurons against diverse neurodegenerative disorders by delivering magnetic stimuli into the brain through the intact scalp. In the current study, the protection effect of rTMS on Parkinson's disease (PD) and the associated mechanism driving the treatment were explored. The PD symptoms were induced using 6-OHDA in mice, and the effect of rTMS of two frequencies (1 Hz and 10 Hz) on the cognitive behaviors and neuron viability was detected. Read More

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http://dx.doi.org/10.1007/s11010-019-03531-wDOI Listing

Blocking P2X7 receptor ameliorates oxidized LDL-mediated podocyte apoptosis.

Mol Biol Rep 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatric Nephrology and Rheumatism and Immunology, Shandong Provincial Hospital Affiliated to Shandong University, No. 324 Jing Wu Road, Jinan, 250021, People's Republic of China.

The purpose of our research is to elucidate whether oxLDL activates P2X7R in cultured human podocytes and if the activation of P2X7R leads to podocyte apoptosis. Additionally, we explore the underlying mechanism involved in podocyte apoptosis. Immortalized human podocytes were incubated with oxLDL (80 µg/ml), P2X7R antagonist A438079 (10 µM), or the compound of A438079 and oxLDL for 48 h, respectively. Read More

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http://dx.doi.org/10.1007/s11033-019-04823-6DOI Listing

Nocebo effect in myasthenia gravis: systematic review and meta-analysis of placebo-controlled clinical trials.

Acta Neurol Belg 2019 Apr 19. Epub 2019 Apr 19.

Academic Department of Neurosciences, Sheffield Teaching Hospitals, NHS Trust, Sheffield, UK.

Nocebo refers to the adverse events (AEs) experienced when taking a placebo drug and is believed to be a centrally mediated process. We sought to examine the AEs following placebo administration in Randomised Controlled Trials (RCTs) for Myasthenia Gravis (MG) patients. A systematic literature search was performed on Medline and Web of Science for RCTs for MG pharmacological treatments. Read More

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http://dx.doi.org/10.1007/s13760-019-01143-1DOI Listing

Inhibition of MicroRNA-195 Alleviates Neuropathic Pain by Targeting Patched1 and Inhibiting SHH Signaling Pathway Activation.

Neurochem Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, Research Institute of Surgery Daping Hospital, Third Military Medical University (Army Medical University), No. 10 Changjiangzhilu Rd, Yuzhong District, Chongqing, 400042, People's Republic of China.

Trigeminal neuralgia (TN) is a type of chronic neuropathic pain that is caused by peripheral nerve lesions that result from various conditions, including the compression of vessels, tumors and viral infections. MicroRNAs (miRs) are increasingly recognized as potential regulators of neuropathic pain. Previous evidence has demonstrated that miR-195 is involved in neuropathic pain, but the mechanism remains unclear. Read More

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http://dx.doi.org/10.1007/s11064-019-02797-2DOI Listing

Muscle-strengthening physical activity is associated with cancer mortality: results from the 1998-2011 National Health Interview Surveys, National Death Index record linkage.

Cancer Causes Control 2019 Apr 19. Epub 2019 Apr 19.

Department of Health Promotion, College of Public Health, University of Nebraska Medical Center, 984340 Nebraska Medical Center, Omaha, NE, 68198-4340, USA.

Purpose: To examine the association of muscle-strengthening activities (MSA) and cancer mortality.

Methods: We pooled data from the 1998 to 2009 National Health Interview Survey (NHIS), which were linked to records in the National Death Index. Mortality follow-up was through 31 December 2011. Read More

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http://dx.doi.org/10.1007/s10552-019-01169-zDOI Listing

Spermine and gene methylation: a mechanism of lifespan extension induced by polyamine-rich diet.

Authors:
Kuniyasu Soda

Amino Acids 2019 Apr 19. Epub 2019 Apr 19.

Cardiovascular Research Institute, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama-City, Saitama, Japan.

The polyamines spermidine and spermine are synthesized in almost all organisms and are also contained in food. Polyamine synthesis decreases with aging, but no significant decrease in polyamine concentrations were found in organs, tissues, and blood of adult animals and humans. We found that healthy dietary patterns were associated with a preference for polyamine-rich foods, and first reported that increased polyamine intake extended the lifespan of mice and decreased the incidence of colon cancer induced by repeated administration of moderate amounts of a carcinogen. Read More

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http://dx.doi.org/10.1007/s00726-019-02733-2DOI Listing

Simulation-based optimization to improve hospital patient assignment to physicians and clinical units.

Health Care Manag Sci 2019 Apr 19. Epub 2019 Apr 19.

The Center for Health and the Social Sciences, University of Chicago, Chicago, IL, 60637, USA.

A fundamental activity in hospital operations is patient assignment, which we define as the process of assigning hospital patients to specific physician services and clinical units based on their diagnosis. When the preferred assignment is not possible, typically due to capacity limits, hospitals often allow for overflow, which is the assignment of patients to other services and/or units. Overflow accelerates assignment, but can also reduce care quality and increase length of stay. Read More

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http://dx.doi.org/10.1007/s10729-019-09483-3DOI Listing

Evaluation of the draft guidelines proposed by EMA and FDA for the clinical diagnosis of acute uncomplicated cystitis in women.

World J Urol 2019 Apr 19. Epub 2019 Apr 19.

Department of Urology, Pediatric Urology and Andrology, Justus-Liebig-University, Rudolph-Buchheim Str.7, 35392, Giessen, Germany.

Purpose: To reassess the diagnostic values of the "draft" guidelines for the clinical diagnosis of acute uncomplicated cystitis (AC), recently proposed by US Food and Drug Administration (FDA) and European Medicines Agency (EMA).

Methods: The data of 517 female respondents (patients with acute cystitis and controls) derived from the e-USQOLAT database were analyzed and used for the validation of proposed "draft" guidelines of FDA and EMA, compared to the Acute Cystitis Symptom Score (ACSS) questionnaire. The diagnostic values of the proposals concerning signs, symptoms and their severity were assessed and compared. Read More

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http://dx.doi.org/10.1007/s00345-019-02761-3DOI Listing

Timing of Intradermal Rabies Pre-exposure Prophylaxis Injections: Immunological Effect on Vaccination Response.

Mil Med 2019 Apr 20. Epub 2019 Apr 20.

Travel Clinic, Centre for Infectious Diseases, Military Hospital Queen Astrid, Rue Bruyn 1, 1120 Neder-Over-Heembeek, Belgium.

Introduction: Rabies remains a global threat, with annually over 59,000 deaths. Intradermal (ID) pre-exposure prophylaxis (PrEP) is very efficient and reduces the need for rabies immunoglobulins. Not much is known about factors that influence the immune response to ID administered rabies vaccine. Read More

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http://dx.doi.org/10.1093/milmed/usz048DOI Listing

Supplementation with Sodium Butyrate Modulates the Composition of the Gut Microbiota and Ameliorates High-Fat Diet-Induced Obesity in Mice.

J Nutr 2019 Apr 20. Epub 2019 Apr 20.

Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, China.

Background: Short-chain fatty acids (SCFAs) have been reported to ameliorate obesity. However, the underlying mechanisms require further investigation.

Objective: The aim of this study was to determine the role of butyrate, an SCFA, in the regulation of obesity, low-grade chronic inflammation, and alterations of microbiota composition in mice. Read More

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http://dx.doi.org/10.1093/jn/nxy324DOI Listing

c-Myb regulates tumorigenic potential of embryonal rhabdomyosarcoma cells.

Sci Rep 2019 Apr 19;9(1):6342. Epub 2019 Apr 19.

Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, 14220, Czech Republic.

Rhabdomyosarcomas (RMS) are a heterogeneous group of mesodermal tumors, the most common sub-types are embryonal (eRMS) and alveolar (aRMS) rhabdomyosarcoma. Immunohistochemical analysis revealed c-Myb expression in both eRMS and aRMS. c-Myb has been reported to be often associated with malignant human cancers. Read More

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http://www.nature.com/articles/s41598-019-42684-y
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http://dx.doi.org/10.1038/s41598-019-42684-yDOI Listing
April 2019
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Honeybee-specific lactic acid bacterial supplements have no effect on American foulbrood infected honeybee colonies.

Appl Environ Microbiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Ecology, Swedish University of Agricultural Sciences, Uppsala, 750 07 Sweden.

, causative agent of American Foulbrood (AFB), is the primary bacterial pathogen affecting honeybees and beekeeping. The main methods for controlling AFB are incineration of diseased colonies or prophylactic antibiotic treatment (e.g. Read More

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http://aem.asm.org/lookup/doi/10.1128/AEM.00606-19
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http://dx.doi.org/10.1128/AEM.00606-19DOI Listing
April 2019
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Efficacy, safety, and pharmacokinetics of emicizumab prophylaxis given every 4 weeks in people with haemophilia A (HAVEN 4): a multicentre, open-label, non-randomised phase 3 study.

Lancet Haematol 2019 Apr 16. Epub 2019 Apr 16.

Hospital Universitario La Paz, Autónoma University, Madrid, Spain.

Background: Emicizumab, a subcutaneously administered, humanised, bispecific, monoclonal antibody, is approved to treat people with haemophilia A of all ages with and without coagulation factor VIII (FVIII) inhibitors. HAVEN 4 assessed emicizumab prophylaxis administered as one dose every 4 weeks in adults and adolescents with haemophilia A, regardless of FVIII inhibitor status.

Methods: In this phase 3, multicentre, open-label, two-stage study, patients aged 12 years and older with severe congenital haemophilia A (<1% of normal FVIII activity in blood) or haemophilia A with FVIII inhibitors, undergoing treatment with either FVIII concentrates or bypassing agents were recruited from three sites in Japan and Spain for a run-in cohort, and from 17 sites in Australia, Belgium, Japan, Poland, Spain, and the USA for a subsequent expansion cohort. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523026193005
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http://dx.doi.org/10.1016/S2352-3026(19)30054-7DOI Listing
April 2019
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Sufficient duration of off-season decreases elbow disorders in elementary school-aged baseball players.

J Shoulder Elbow Surg 2019 Apr 16. Epub 2019 Apr 16.

Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan.

Background: Several guidelines for the prevention of throwing injuries recommend a sufficiently long off-season; however, few studies providing scientific evidence to support these recommendations exist. Our study aimed to clarify the association between off-season duration and throwing elbow injuries among elementary school-aged baseball players.

Methods: This study enrolled 680 elementary school-aged baseball players who underwent medical checkups. Read More

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http://dx.doi.org/10.1016/j.jse.2019.02.005DOI Listing

Gemifloxacin-Induced Allergic Myocardial Infarction: A Case Report.

J Emerg Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Cardiology, Faculty of Medicine, Muğla University, Muğla, Turkey.

Background: Gemifloxacin given once daily for 5-7 days has been shown to be non-inferior to, or in some instances superior to, comparator agents for the treatment of common lower respiratory tract infections. Gemifloxacin is generally well tolerated and is as safe as many frequently empirically prescribed antimicrobials.

Case Report: We report a case of a 46-year-old woman given gemifloxacin for an upper respiratory tract infection who developed allergic myocardial infarction 15 min after taking an oral dose of 320 mg gemifloxacin. Read More

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http://dx.doi.org/10.1016/j.jemermed.2019.03.001DOI Listing

The Impact of Social Determinants of Health on Hospitalization in the Veterans Health Administration.

Am J Prev Med 2019 Apr 16. Epub 2019 Apr 16.

Center for Population Health IT, Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Introduction: This study aims to assess the effect of individual and geographic-level social determinants of health on risk of hospitalization in the Veterans Health Administration primary care clinics known as the Patient Aligned Care Team.

Methods: For a population of Veterans enrolled in the primary care clinics, the study team extracted patient-level characteristics and healthcare utilization records from 2015 Veterans Health Administration electronic health record data. They also collected census data on social determinants of health factors for all U. Read More

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http://dx.doi.org/10.1016/j.amepre.2018.12.012DOI Listing

Monocyte-platelet aggregates affect local inflammation in patients with acute myocardial infarction.

Int J Cardiol 2019 Apr 8. Epub 2019 Apr 8.

Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar, Technische Universität München, Munich, Germany. Electronic address:

The local inflammatory response following acute myocardial infarction (AMI) is increasingly being recognized as a central factor determining infarct healing. Myocardial inflammation can be visualized in patients using fasting F-FDG PET/MRI. Although this novel biosignal correlates with long-term functional outcome, the corresponding cellular substrate is not well understood. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.04.009DOI Listing
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