3,773,637 results match your criteria Administration & Society[Journal]


Effect of Fentanyl Boluses on Cerebral Oxygenation and Hemodynamics in Preterm Infants: A Prospective Observational Study.

Neonatology 2020 Jul 8:1-8. Epub 2020 Jul 8.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Dalhousie University and IWK Health Center, Halifax, Nova Scotia, Canada.

Background: Fentanyl is a commonly used off-label medication for pain control and sedation in preterm infants. Yet, the effect of fentanyl on cerebral hemodynamics in preterm neonates remains unexplored.

Objective: To evaluate the effect of a bolus dose of fentanyl on the regional cerebral oxygen saturation (RcSO2), cerebral fractional tissue oxygen extraction (cFTOE) and left ventricular output (LVO) as compared with pre-administration baseline in preterm infants. Read More

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http://dx.doi.org/10.1159/000508555DOI Listing

Roles of Thyroid Hormones, Mast Cells, and Inflammatory Mediators in the Initiation and Progression of Autoimmune Thyroid Diseases.

Int Arch Allergy Immunol 2020 Jul 8:1-12. Epub 2020 Jul 8.

Department of Clinical Immunology and Allergy Sechenov, First Moscow State Medical University, Moscow, Russian Federation.

Background: Interrelation between thyrocytes and immunocytes has been established. However, the roles of mast cells and thyroid hormones in the triggering mechanism of thyroid autoimmune processes have been insufficiently investigated. This study evaluated the role of thyroid hormones and mast cells in the mechanisms of losing tolerance to thyroid autoantigens. Read More

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http://dx.doi.org/10.1159/000508937DOI Listing

N-acetylcysteine prevents verapamil-induced cardiotoxicity with no effect on the noradrenergic arch-associated neurons in zebrafish.

Food Chem Toxicol 2020 Jul 5:111559. Epub 2020 Jul 5.

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Electronic address:

There is a strong association between calcium channel blockers (CCBs) and heart failure. CCB toxicity is very common due to overdose and underlying medical conditions. CCBs also have been shown to affect the nervous system. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111559DOI Listing

Induction of autophagy by Beclin-1 in granulosa cells contributes to follicular progesterone elevation in ovarian endometriosis: BECN1 and P4 elevation in endometriosis.

Transl Res 2020 Jul 5. Epub 2020 Jul 5.

Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200135, China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, 200135, China.

Endometriosis is a common gynecological disease in which ovarian dysfunction can be an important cause of infertility. Elevated progesterone (P4) levels during the follicular phase is possibly associated with impaired oocyte quality and pregnancy outcome in endometriosis. Beclin-1 (BECN1), an essential mediator of autophagy, has been shown to be related to the development and progression of endometriosis. Read More

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http://dx.doi.org/10.1016/j.trsl.2020.06.013DOI Listing

Carbon Dioxide Laser Resurfacing for Rhinophyma: A Case Report and Discussion of the Literature.

J Oral Maxillofac Surg 2020 Jun 13. Epub 2020 Jun 13.

Professor, Division of Oral and Maxillofacial Surgery, Departments of Surgery and Cell Biology, UT Southwestern Medical Center; and Chief, Department of Oral and Maxillofacial Surgery, Veterans Administration North Texas Healthcare System, Dallas, TX.

Rhinophyma, an unsightly and obstructive skin lesion of the nasal area, can be difficult to treat. Numerous modalities have been tried, including medical, excision, and ablation, with various tools and results. In the present report, we have demonstrated the use of the carbon dioxide (CO) laser on the nose of a 56-year-old man, with excellent cosmetic results even at 59 months after treatment. Read More

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http://dx.doi.org/10.1016/j.joms.2020.06.012DOI Listing

Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for ALS.

N Engl J Med 2020 Jul;383(2):109-119

From the Washington University School of Medicine, St. Louis (T.M., R.C.B., A.P.); the Healey Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston (M.C., N.A.), and Biogen, Cambridge (A.S., H.R., D.G., H.H., A.M., I.N., I.C., L.F., S.F., T.A.F.) - both in Massachusetts; the Sheffield Institute for Translational Neuroscience, University of Sheffield, and NIHR Sheffield Biomedical Research Centre and Clinical Research Facility, University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield (P.J.S., C.J.M.), and Biogen, Maidenhead (M.M.) - both in the United Kingdom; the Department of Clinical Science, Neurosciences, Umeå University, Umea, Sweden (P.M.A.); Montreal Neurological Institute and Hospital, Montreal (A.G.), and Sunnybrook Research Institute, Toronto (L.Z.); Emory University, Atlanta (J.G.); Barrow Neurological Institute, Phoenix, AZ (S.L.); the University of Ulm, Ulm, Germany (A.L.L.); Johns Hopkins University School of Medicine, Baltimore (N.J.M.); the University of California San Diego, La Jolla (J.R.), and Ionis Pharmaceuticals, Carlsbad (C.F.B., R.L.) - both in California; Paris ALS Centre, Hôpital de la Salpêtrière, Paris (F.S.); the University of Tennessee Medical Center, Knoxville (R.T.); and KU Leuven, VIB Center for Brain and Disease Research, University Hospitals Leuven, Leuven, Belgium (P.V.D.).

Background: Tofersen is an antisense oligonucleotide that mediates the degradation of superoxide dismutase 1 (SOD1) messenger RNA to reduce SOD1 protein synthesis. Intrathecal administration of tofersen is being studied for the treatment of amyotrophic lateral sclerosis (ALS) due to mutations.

Methods: We conducted a phase 1-2 ascending-dose trial evaluating tofersen in adults with ALS due to mutations. Read More

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http://dx.doi.org/10.1056/NEJMoa2003715DOI Listing

Ensuring Choice for People with Kidney Failure - Dialysis, Supportive Care, and Hope.

N Engl J Med 2020 Jul;383(2):99

From the Division of Nephrology and Hypertension and Kidney Transplantation (K.K.-Z.) and the Division of Palliative Medicine, Hospitalist Program (S.L.), University of California, Irvine, School of Medicine, Orange, and the Tibor Rubin Veterans Administration Healthcare System, Long Beach (K.K.-Z.) - both in California; and the Division of Bioethics and Palliative Care and Division of Nephrology, Department of Pediatrics, University of Washington School of Medicine, and Treuman Katz Center for Pediatric Bioethics, Seattle Children's Hospital - both in Seattle (A.W.).

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http://dx.doi.org/10.1056/NEJMp2001794DOI Listing

Lactic acid bacteria feeding reversed the malformed eye structures and ameliorated gut microbiota profiles of Drosophila melanogaster Alzheimer's Disease model.

J Appl Microbiol 2020 Jul 8. Epub 2020 Jul 8.

CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

Aims: To utilize transgenic GMR-Aβ42 Drosophila melanogaster as a model to evaluate potential Alzheimer's disease (AD)-reversal effects via the administration of lactic acid bacteria (LAB) strains, and associations of LAB with changes in gut microbiota profiles.

Methods And Results: Wild type flies (Oregon-R) was crossed with glass multimer reporter-GAL4 (GMR-GAL4) to produce GMR-OreR (Control), while UAS-Aβ42 (#33769) crossed with GMR-GAL4 to produce transgenic Drosophila line that expressed Aβ42 (GMR-Aβ42). Feed containing seven different LAB strains (Lactobacillus paracasei 0291, Lactobacillus helveticus 1515, Lactobacillus reuteri CDV, Lactobacillus reuteri 8513d, Lactobacillus fermentum 8312, Lactobacillus casei Y, Lactobacillus sakei Probio65) were given to GMR-Aβ42 respectively, while feed without LAB strains were given to control and transgenic GMR-Aβ42. Read More

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http://dx.doi.org/10.1111/jam.14773DOI Listing

Broadening Eligibility Criteria for Oncology Clinical Trials: Current Advances and Future Directions.

Clin Pharmacol Ther 2020 Jul 8. Epub 2020 Jul 8.

US Food and Drug Administration, White Oak, Maryland, USA.

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http://dx.doi.org/10.1002/cpt.1919DOI Listing

Non-Invasive Venous waveform Analysis (NIVA) for volume assessment during complex cranial vault reconstruction: A proof-of-concept study in children.

PLoS One 2020 8;15(7):e0235933. Epub 2020 Jul 8.

VoluMetrix, LLC, Nashville, TN, United States of America.

Background: Non-Invasive Venous waveform Analysis (NIVA) is novel technology that captures and analyzes changes in venous waveforms from a piezoelectric sensor on the wrist for hemodynamic volume assessment. Complex cranial vault reconstruction is performed in children with craniosynostosis and is associated with extensive blood loss, potential life-threatening risks, and significant morbidity. In this preliminary study, we hypothesized that NIVA will provide a reliable, non-invasive, quantitative assessment of intravascular volume changes in children undergoing complex cranial vault reconstruction. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235933PLOS

The endosymbiont Wolbachia rebounds following antibiotic treatment.

PLoS Pathog 2020 Jul 8;16(7):e1008623. Epub 2020 Jul 8.

Dept. of Pharmaceutical Chemistry; University of California, San Francisco; San Francisco, California, United States of America.

Antibiotic treatment has emerged as a promising strategy to sterilize and kill filarial nematodes due to their dependence on their endosymbiotic bacteria, Wolbachia. Several studies have shown that novel and FDA-approved antibiotics are efficacious at depleting the filarial nematodes of their endosymbiont, thus reducing female fecundity. However, it remains unclear if antibiotics can permanently deplete Wolbachia and cause sterility for the lifespan of the adult worms. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008623DOI Listing

Effect of thermal ballast loading on temperature stability of domestic refrigerators used for vaccine storage.

PLoS One 2020 8;15(7):e0235777. Epub 2020 Jul 8.

Physical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland, United States of America.

Vaccine temperature control failures represent a significant public and private healthcare cost. Vaccines damaged by excessive heat or freezing lose their effectiveness, putting public health at risk. Some vaccine administration programs recommend placing water bottles inside domestic refrigerators used for vaccine storage as a thermal ballast, to mitigate temperature excursion risks. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235777PLOS

Choosing between the UN's alternative views of population aging.

PLoS One 2020 8;15(7):e0233602. Epub 2020 Jul 8.

Wittgenstein Centre for Demography and Global Human Capital (Univ. Vienna, IIASA, VID/ÖAW), International Institute for Applied Systems Analysis, Laxenburg, Austria.

Commonly used measures of population aging categorize adults into those who are "old" and those who are not. How this threshold of the stage of "old age" is determined is crucial for our understanding of population aging. We propose that the old age threshold be determined using an equivalency criterion. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233602PLOS

State Policymaking and Prescription Drug-Monitoring Programs: A Look Ahead.

Authors:
Michael R Fraser

Am J Public Health 2020 Aug;110(8):1117-1118

Michael R. Fraser is chief executive officer at the Association of State and Territorial Health Officials and is affiliate faculty in the Departments of Community Health and Health Administration and Policy, College of Health and Human Services, George Mason University, Fairfax, VA.

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http://dx.doi.org/10.2105/AJPH.2020.305762DOI Listing

A National Measurement Framework to Assess and Improve Sickle Cell Care in 4 US Regions.

Public Health Rep 2020 Jul 8:33354920935068. Epub 2020 Jul 8.

50980 National Institute for Children's Health Quality, Boston, MA, USA.

Objectives: Coordinated measurement strategies are needed to inform collaborative approaches to improve access to and quality of care for persons with sickle cell disease (SCD). The objective of our study was to develop a multilevel measurement strategy to assess improvements in access to and quality of care for persons with SCD in 4 US regions.

Methods: From 2014 through 2017, regional grantees in the Sickle Cell Disease Treatment Demonstration Program collected administrative and patient-level electronic health record (EHR) data to assess quality improvement initiatives. Read More

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http://dx.doi.org/10.1177/0033354920935068DOI Listing

Immediate histologic correlation in women with atypical squamous cells of undetermined significance cytology and positive high-risk HPV: A retrospective review of 6000 cases in a large academic women's hospital.

Cancer Cytopathol 2020 Jul 8. Epub 2020 Jul 8.

Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Background: Previous studies of the histologic correlation in women who have atypical squamous cells of undetermined significance cytology (ASC-US) and are positive for high-risk human papillomavirus (hrHPV+) have predominantly utilized the Hybrid Capture 2 (HC2) test, whereas the use of other US Food and Drug Administration (FDA)-approved methods is relatively limited.

Methods: Cases of ASC-US/hrHPV+ that were tested using HC2, Cervista, or Aptima were retrieved, and the immediate histologic correlations were analyzed.

Results: Overall, 53. Read More

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http://dx.doi.org/10.1002/cncy.22314DOI Listing

Microtomographic analysis of the effect of sodium alendronate on orthodontic movement in rats.

Orthod Craniofac Res 2020 Jul 8. Epub 2020 Jul 8.

Department of Dentistry, Christus University Center, Fortaleza, Ceará, Brazil.

Objective: To evaluate the effect of sodium alendronate on orthodontic movement in rats using microtomographic analysis. Settings and Sample population: Thirty male Wistar rats (Rattus norvegicus) divided into the following three groups of 10 rats each: 1) control (saline); 2) 1 mg/kg sodium alendronate; and 3) 6 mg/kg sodium alendronate.

Materials And Methods: The drug was administered once per week for 5 weeks by gavage. Read More

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http://dx.doi.org/10.1111/ocr.12410DOI Listing

Voriconazole therapeutic drug monitoring in critically ill patients improves efficacy and safety of antifungal therapy.

Basic Clin Pharmacol Toxicol 2020 Jul 8. Epub 2020 Jul 8.

Department of Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, Shaanxi, China.

Since voriconazole plasma trough concentration (VPC) is related to its efficacy and adverse events, therapeutic drug monitoring (TDM) is recommended to perform. However, there is no report about the data of voriconazole TDM in critically ill patients in China. This retrospective study was performed to determine whether voriconazole TDM was associated with treatment response and/or voriconazole adverse events in critically ill patients, and to identify the potential risk factors associated with VPC. Read More

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http://dx.doi.org/10.1111/bcpt.13465DOI Listing

Urban-Rural Disparities in Opioid Use Disorder Prevention and Response Activities: A Cross-Sectional Analysis.

J Rural Health 2020 Jul 8. Epub 2020 Jul 8.

The Schreiber Research Group, Denver, Colorado.

Purpose: Urban and rural areas have been differentially impacted by opioid use disorder (OUD) and related adverse outcomes, yet little systematic study of the urban-rural divide in OUD prevention and response activities exists. This study compares policy and programmatic activities to tackle the opioid crisis in metropolitan versus nonmetropolitan areas, and within their subclassifications.

Methods: All county governments in 5 purposively selected states were surveyed. Read More

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http://dx.doi.org/10.1111/jrh.12491DOI Listing

Comparison of the Effects of Low-Molecular-Weight Heparin and Fondaparinux on Liver Function in Patients With Pulmonary Embolism.

J Clin Pharmacol 2020 Jul 8. Epub 2020 Jul 8.

Thrombosis Center, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Hepatotoxicity with low-molecular-weight heparin (LMWH) or fondaparinux is a relatively common adverse reaction. This study assessed the effects of LMWH and fondaparinux on liver function in patients with pulmonary embolism based on a retrospective cohort. As a result, a total of 463 patients with pulmonary embolism and treated with LMWH (enoxaparin sodium or nadroparin calcium) or fondaparinux sodium were included. Read More

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http://dx.doi.org/10.1002/jcph.1686DOI Listing

Direct Oral to Parenteral Anticoagulants: Strategies for Inpatient Transition.

J Clin Pharmacol 2020 Jul 8. Epub 2020 Jul 8.

Department of Pharmacy, Houston Methodist Hospital, Houston, Texas, USA.

The primary objective of this study was to describe the impact on bleeding rates of 2 different strategies for transitioning from a direct oral anticoagulant (DOAC) to a parenteral anticoagulant: a delayed, clinically driven strategy versus the standard per-package-insert strategy. This was a single-center descriptive cohort study conducted at a large academic medical center. Included patients were 18 years or older, admitted as an inpatient, and had received at least 1 dose of a DOAC prior to initiation of therapeutic parenteral anticoagulation. Read More

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http://dx.doi.org/10.1002/jcph.1694DOI Listing

New Organometallic Ruthenium(II) Compounds Synergistically Show Cytotoxic, Antimetastatic and Antiangiogenic Activities for the Treatment of Metastatic Cancer.

Chemistry 2020 Jul 8. Epub 2020 Jul 8.

Zhejiang University School of Medicine, First Affiliated Hospital, Ministry of Public Health, 79, Qingchun Road, 310003, Hangzhou, CHINA.

In this study, we newly designed and synthesized a small library of ten structurally related C,N-cyclometalated ruthenium(II) complexes containing various pyridine-functionalized NHC ligand and chelating bipyridyl ligands (e.g., 2,2'-bipyridine, 5,5'-dimethyl-2,2'-bipyridine, and 1,10-phenanthroline (phen)). Read More

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http://dx.doi.org/10.1002/chem.202002970DOI Listing

National Geriatric Network Rapidly Addresses Trainee Telehealth Needs in Response to COVID-19.

J Am Geriatr Soc 2020 Jul 8. Epub 2020 Jul 8.

Bedford VA Medical Center, Division of the New England Geriatric Research Education and Clinical Center, Bedford, Massachusetts.

Background/objectives: COVID-19 has pushed many geriatric healthcare providers to attempt video visits for the first time. While the Veterans Health Administration (VA) is a pioneer in telemedicine, rapid shifts to nearly exclusive use of telehealth for healthcare delivery and changes regarding trainee engagement in telehealth served as the impetus for rapidly assessing telehealth training needs.

Design/setting/participants: Trainees (n=89) representing 12 disciplines affiliated with VA Geriatric Research Education and Clinical Centers (GRECCs) were surveyed regarding prior experience conducting video-to-home visits and training needs. Read More

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http://dx.doi.org/10.1111/jgs.16704DOI Listing

Association of Smoking Cessation and Survival Among Young Adults With Myocardial Infarction in the Partners YOUNG-MI Registry.

JAMA Netw Open 2020 Jul 1;3(7):e209649. Epub 2020 Jul 1.

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Importance: Despite significant progress in primary prevention, the rate of myocardial infarction (MI) continues to increase in young adults.

Objectives: To identify the prevalence of tobacco use and to examine the association of both smoking and smoking cessation with survival in a cohort of adults who experienced an initial MI at a young age.

Design, Setting, And Participants: The Partners YOUNG-MI registry is a retrospective cohort study from 2 large academic centers in Boston, Massachusetts, that includes patients who experienced an initial MI at 50 years or younger. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.9649DOI Listing

Quality of Life Assessed Using Skindex-16 Scores Among Patients With Acne Receiving Isotretinoin Treatment.

JAMA Dermatol 2020 Jul 8. Epub 2020 Jul 8.

Department of Population Health Sciences, University of Utah, Salt Lake City.

Importance: Acne is a common dermatologic condition and significantly affects psychosocial health and quality of life. An international task force recommended routine use of quality-of-life measures for clinic visits associated with acne management, but this has yet to translate into clinical practice.

Objective: To assess mean Skindex-16 scores over time among patients with moderate to severe acne receiving isotretinoin treatment. Read More

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http://dx.doi.org/10.1001/jamadermatol.2020.2330DOI Listing

A Randomized, Controlled Pharmacokinetic and Pharmacodynamics Trial of Ambrisentan After Fontan Surgery.

Pediatr Crit Care Med 2020 Jun 26. Epub 2020 Jun 26.

Division of Pediatric Cardiology, Department of Pediatrics, Duke University Pediatric and Congenital Heart Center, Durham, NC.

Objectives: To determine the pharmacokinetics, pharmacodynamics, and safety of the hepatically metabolized endothelin receptor antagonist, ambrisentan in children after Fontan surgery.

Design: Prospective, randomized, double-blind, placebo-controlled pharmacokinetic/pharmacodynamics and safety trial.

Setting: Single-center, postoperative cardiac ICU. Read More

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http://dx.doi.org/10.1097/PCC.0000000000002410DOI Listing

PrEvention of post-traumatic contractuRes with Ketotifen 1 (PERK 1): A randomized clinical trial.

J Orthop Trauma 2020 Jun 29. Epub 2020 Jun 29.

Associate Professor, Departments of Community Health Sciences & Clinical Neurosciences, Cumming School of Medicine, University of Calgary.

Objective: To assess the use of Ketotifen Fumarate (KF) to reduce post-traumatic contractures following elbow fractures and/or dislocations.

Design: Randomized clinical trial.

Setting: Three hospitals in Calgary, Canada including one Level 1 trauma center. Read More

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http://dx.doi.org/10.1097/BOT.0000000000001878DOI Listing

Using Technology to Combat Clinician Burnout.

Authors:
Matthew J Davis

J Healthc Manag 2020 Jul-Aug;65(4):265-272

Auburn University Health Services Administration Program, Auburn, Alabama.

Executive Summary: Physician burnout is a major problem affecting healthcare providers. It not only influences clinician mental health but also clinical outcomes, patient satisfaction, and the financial standing of a health system. A combination of web and mobile applications can be used to treat clinician burnout by effectively reducing stress, anxiety, and depression. Read More

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http://dx.doi.org/10.1097/JHM-D-20-00099DOI Listing

A Preliminary Examination of Endogenous Peripheral Oxytocin in a Pilot Randomized Clinical Trial of Oxytocin-Enhanced Psychotherapy for Posttraumatic Stress Disorder.

J Clin Psychopharmacol 2020 Jul/Aug;40(4):401-404

MUSC Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina.

Background: Preclinical and clinical research suggests that the oxytocin system is implicated in the development and maintenance of stress and anxiety-related psychiatric conditions, such as posttraumatic stress disorder (PTSD). Recent research also suggests that intranasal oxytocin holds promise as a treatment for PTSD. However, little is known about the relationship between levels of peripheral oxytocin and PTSD symptom severity, PTSD treatment response, and repeated intranasal oxytocin administration. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001226DOI Listing

Antidepressants and Risk of Type 2 Diabetes Mellitus: A Population-Based Nested Case-Control Study.

J Clin Psychopharmacol 2020 Jul/Aug;40(4):359-365

From the Departments of Psychiatry.

Purpose/background: The increased risk of type 2 diabetes mellitus (T2DM) among users of antidepressants (ADs) might be mediated by depression. We investigated whether ADs are associated with increased risk of T2DM in patients with depression. Moreover, the relationship between binding affinities of serotonin transporter (SERT) of ADs and the risk of T2DM is examined. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001228DOI Listing

Food and Drug Administration-Approved Treatments for Acute Bipolar Depression: What We Have and What We Need.

Authors:
Leslie Citrome

J Clin Psychopharmacol 2020 Jul/Aug;40(4):334-338

From the New York Medical College, Valhalla, NY.

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http://dx.doi.org/10.1097/JCP.0000000000001227DOI Listing

Beneficial effects of low-dose lithium on cognitive ability and pathological alteration of Alzheimer's disease transgenic mice model.

Neuroreport 2020 Jul 3. Epub 2020 Jul 3.

Department of Neurology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Lithium has been shown to delay the progression of Alzheimer's disease to reduce the prevalence of dementia. However, its narrow therapeutic index and numerous toxic effects at conventional dosage limited its long-term use to older subjects. Here, we tested the effect of low-dose lithium on cognitive impairment and pathology alterations in a mouse model of Alzheimer's disease, the amyloid precursor protein/presenilin-1 (APP/PS1) transgenic mouse. Read More

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http://dx.doi.org/10.1097/WNR.0000000000001499DOI Listing

Survey of Telehealth Adoption by Neuro-ophthalmologists During the COVID-19 Pandemic: Benefits, Barriers and Utility.

J Neuroophthalmol 2020 Jun 30. Epub 2020 Jun 30.

Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.

Background: During the COVID-19 pandemic tele-health modalities have come to prominence as a strategy for providing patient care when in-person care provision opportunities are limited. The degree of adoption by neuro-ophthalmologists has not been quantified.

Methods: Telehealth utilization pre- and peri-COVID-19 was surveyed among practicing neuro-ophthalmologists in and outside the US using an on-line platform. Read More

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http://dx.doi.org/10.1097/WNO.0000000000001051DOI Listing

Biodegradable Nanoparticles Based on Pseudo-Proteins Show Promise as Carriers for Ophthalmic Drug Delivery.

J Ocul Pharmacol Ther 2020 Jul 7. Epub 2020 Jul 7.

Research Lab of the Department of Ophthalmology, University of Münster Medical School, Münster, Germany.

Drug delivery to treat ocular diseases still is a challenge in ophthalmology. One way to achieve drug delivery that is investigated currently is topical administration of drug-loaded polymeric nanoparticles (NPs) that are able to penetrate ocular barriers. The purpose of this study was optimal preparation of NPs made from pseudo-proteins and evaluation of their ability to penetrate ocular tissues. Read More

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http://dx.doi.org/10.1089/jop.2019.0148DOI Listing

Consideration of Tranexamic Acid Administration to COVID-19 Patients.

Physiol Rev 2020 Oct;100(4):1595-1596

Department of Environmental and Preventive Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan; and Department of Hematology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan.

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http://dx.doi.org/10.1152/physrev.00023.2020DOI Listing
October 2020

Effect of icosapent ethyl on susceptibility to ventricular arrhythmias in postinfarcted rat hearts: Role of GPR120-mediated connexin43 phosphorylation.

J Cell Mol Med 2020 Jul 8. Epub 2020 Jul 8.

Cardiovascular Institute, An Nan Hospital, China Medical University, Tainan, Taiwan.

The ω-3 fatty acids exert as an antioxidant via the G protein-coupled receptor 120 (GPR120). Icosapent ethyl, a purified eicosapentaenoic acid, showed a marked reduction in sudden cardiac death. Connexin43 is sensitive to redox status. Read More

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http://dx.doi.org/10.1111/jcmm.15575DOI Listing

Oral administration of royal jelly may improve the preservation of rooster spermatozoa.

J Anim Physiol Anim Nutr (Berl) 2020 Jul 8. Epub 2020 Jul 8.

Department of Animal Science, College of Animal Science and Fisheries, Sari Agricultural Sciences and Natural Resources University, Sari, Iran.

The aim of the present study was to investigate the effect of dietary supplementation of royal jelly (RJ) on liquid and frozen storage of rooster spermatozoa. Twenty-five 30-week-old of Mazandaran native breeder roosters were randomly divided into five treatments (n = 5 roosters/group). Experimental treatments are designed to include a control group and various levels (0. Read More

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http://dx.doi.org/10.1111/jpn.13415DOI Listing

Patient safety challenges in primary health care: a scoping review.

Rev Bras Enferm 2020 6;73(5):e20190209. Epub 2020 Jul 6.

Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

Objectives: to identify the patient safety challenges described by health professionals in Primary Health Care.

Methods: a scoping review was conducted on the LILACS, MEDLINE, IBECS, BDENF, and CINAHL databases, and on the Cochrane, SciELO, Pubmed, and Web of Science libraries in January 2019. Original articles on patient safety in the context of Primary Health Care by health professionals were included. Read More

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http://dx.doi.org/10.1590/0034-7167-2019-0209DOI Listing

Drug scheduling by nurses and drug interactions in patients with cardiovascular diseases.

Rev Bras Enferm 2020 6;73(5):e20190307. Epub 2020 Jul 6.

Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.

Objectives: to identify and characterize the potential serious drug interactions in patients hospitalized with cardiovascular diseases, relating them to the schedules established for drug administration by nurses.

Methods: a documentary, quantitative and sectional research. Ninety-nine prescriptions from patients admitted to the cardiology ward of a hospital in Rio de Janeiro for more than 48 hours were analyzed. Read More

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http://dx.doi.org/10.1590/0034-7167-2019-0307DOI Listing

Involvement of redox status and the nuclear-related factor 2 in protecting against cadmium-induced renal injury with Sana Makki (Cassia senna L.) pre-treatment in male rats.

An Acad Bras Cienc 2020 6;92(2):e20191237. Epub 2020 Jul 6.

Department of Botany and Microbiology, King Saud University, Saudi Arabia.

This study was designed to investigate the potential defensive strategy of Sana Makki extract (SME) against Cd-induced in vivo nephrotoxicity and its underlying mechanisms. Male albino rats were used in a thirty days study comparing control, SME-treated, CdCl2-treated, and combined SME and Cd treatment. Pre-treatment with SME significantly reduced serum kidney biomarkers (urea and creatinine), the concentration of renal KIM-1, and kidney index values. Read More

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http://dx.doi.org/10.1590/0001-3765202020191237DOI Listing

Resveratrol inhibits TNF-α-induced inflammation to protect against renal ischemia/reperfusion injury in diabetic rats.

Acta Cir Bras 2020 Jul 3;35(5):e202000506. Epub 2020 Jul 3.

PhD, Full Professor, Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China. Design and supervised all phases of the study, critical revision, final approval.

Purpose: To examine effects of resveratrol on renal ischemia/ reperfusion injury (I/R) in a streptozotocin (STZ)-induced diabetic rat model.

Methods: Twenty-four male Sprague Dawley rats were treated with STZ injection for the development of diabetes, and divided into the following groups: Sham group, I/R group and Resveratrol group (n=8). Resveratrol (RSV) was administered at a dose of 10 mg. Read More

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http://dx.doi.org/10.1590/s0102-865020200050000006DOI Listing

The influence of platelet-rich plasma (PRP) on colonic anastomosis healing impaired by intraperitoneal 5-flourouracil application. An experimental study.

Acta Cir Bras 2020 Jul 6;35(5):e202000504. Epub 2020 Jul 6.

MD, Department of General Surgery, University of Health Sciences Adana City Training and Research Hospital, Adana, Turkey. Acquisition of data.

Purpose: 5-flourourasil (5-FU) is commonly used for early intraperitoneal chemotherapy in colorectal or appendiceal cancer patients with peritoneal carcinomatosis. Due to its effect, anastomosis healing can be impaired and leads to anastomotic leakage. In this study, we aimed to investigate the potential healing effect of platelet-rich plasma (PRP) on colonic anastomosis impaired by intraperitoneal 5-flourouracil application. Read More

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http://dx.doi.org/10.1590/s0102-865020200050000004DOI Listing

Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways.

Med Sci Monit 2020 Jul 8;26:e923073. Epub 2020 Jul 8.

College of Acupuncture, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China (mainland).

BACKGROUND The aim of this study was to explore whether letrozole and high-fat diets (HFD) can induce obese insulin-resistant polycystic ovary syndrome (PCOS) with all reproductive and metabolic phenotypes in a rat model. MATERIAL AND METHODS Twenty-four 3-week-old female Sprague-Dawley rats were randomized into 4 groups: control, Letrozole, HFD, and Letrozol+HFD. The PCOS model was induced by 12 weeks of Letrozole treatment (1 mg/kg p. Read More

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http://dx.doi.org/10.12659/MSM.923073DOI Listing

An environmental scan of wellness initiatives and programs at Canadian academic emergency medicine programs: How far have we come?

CJEM 2020 Jun 23:1-7. Epub 2020 Jun 23.

Division of Emergency Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, London, ON.

Objectives: We sought to conduct a major objective of the Canadian Association of Emergency Physicians (CAEP) Wellness Committee, an environmental scan of the academic emergency medicine programs across the 17 Canadian medical schools.

Methods: An 89-question questionnaire was distributed to academic heads or wellness leads. The responses were verified by the lead author to ensure that the questions were answered completely and consistently. Read More

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http://dx.doi.org/10.1017/cem.2020.408DOI Listing

Effects of subcutaneous esketamine on blood pressure and heart rate in treatment-resistant depression.

J Psychopharmacol 2020 Jul 8:269881120922955. Epub 2020 Jul 8.

Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil.

Introduction And Objectives: The impact of multiple subcutaneous (s.c.) esketamine injections on the blood pressure (BP) and heart rate (HR) of patients with unipolar and bipolar treatment-resistant depression (TRD) is poorly understood. Read More

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http://dx.doi.org/10.1177/0269881120922955DOI Listing

Evaluation of Cost, Workflow, and Safety of Implementing a Vial Transfer Device for Ready-to-Mix Drugs at an Academic Medical Center.

J Pharm Pract 2020 Jul 8:897190020938195. Epub 2020 Jul 8.

Department of Pharmacy Services, Brigham and Women's Hospital, Boston, MA, USA.

Objective: To evaluate the cost, workflow, and safety of implementing a vial transfer device system.

Methods: In this retrospective analysis, pharmacy systems and electronic health record reports identified high-volume and high-cost medications prepared by a Vial2Bag (V2B) system from July 2017 to June 2018. The major outcome was the extrapolated yearly cost avoidance (EYCA) from utilization of a V2B system, calculated by subtracting total costs of the V2B system from total cost of ready-to-use products and locally compounded sterile products. Read More

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http://dx.doi.org/10.1177/0897190020938195DOI Listing

Hyperbaric Oxygen Therapy and Vascular Complications in Diabetes Mellitus.

Angiology 2020 Jul 8:3319720936925. Epub 2020 Jul 8.

Department of Radiobiology and Molecular Genetics, "VINČA" Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.

Vascular complications in patients with diabetes mellitus (DM) are common. Since impaired oxygen balance in plasma plays an important role in the pathogenesis of chronic DM-associated complications, the administration of hyperbaric oxygen therapy (HBOT) has been recommended to influence development of vascular complications. Hyperbaric oxygen therapy involves inhalation of 100% oxygen under elevated pressure from 1. Read More

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http://dx.doi.org/10.1177/0003319720936925DOI Listing

ARMC5 variants in PRKAR1A-mutated patients modify cortisol levels and Cushing's syndrome.

Endocr Relat Cancer 2020 Jul 1. Epub 2020 Jul 1.

C Stratakis, Section on Endocrinology and Genetics (SEGEN), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, United States.

Mutations in the protein kinase A (PKA) regulatory subunit type 1A (PRKAR1A) and armadillo repeat-containing 5 (ARMC5) genes cause Cushing's syndrome (CS) due to primary pigmented nodular adrenocortical disease (PPNAD) and primary bilateral macronodular adrenocortical hyperplasia (PBMAH), respectively. Between the two genes, ARMC5 is highly polymorphic with several variants in the population, whereas PRKAR1A has very little, if any, non-pathogenic variation in its coding sequence. We tested the hypothesis that ARMC5 variants may affect the clinical presentation of PPNAD and CS among patients with PRKAR1A mutations. Read More

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http://dx.doi.org/10.1530/ERC-20-0273DOI Listing

Cross-cultural adaptation and validation of the Victorian Institute of Sports Assessment for Gluteal Tendinopathy questionnaire in Italian and investigation of the association between tendinopathy-related disability and pain.

Eur J Phys Rehabil Med 2020 Jul 7. Epub 2020 Jul 7.

Department of Musculoskeletal Disorders, University of Salerno School of Medicine, Surgery and Dentistry, Salerno, Italy.

Background: The Victorian Institute of Sports Assessment for Gluteal tendinopathy (VISA-G) questionnaire has recently been proposed as a condition specific patient reported outcome measurement tool to assess the tendinopathyrelated disability.

Aim: To evaluate the reliability of the Italian version of the VISA-G questionnaire and its construct validity and to investigate the association between tendinopathyrelated disability and pain.

Design: Cross-sectional study. Read More

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http://dx.doi.org/10.23736/S1973-9087.20.06209-7DOI Listing

Optimising the absorption of medicines.

Authors:
Jodie Coulson

Nurs Stand 2020 Jul 29;35(7):61-66. Epub 2020 Jun 29.

Department of Health Sciences, University of York, York, England.

The speed and extent of medicine absorption in the human body are affected by numerous interrelated pharmacokinetic factors. To maximise therapeutic benefit and ensure patient safety, nurses require an optimal understanding of these factors. The Royal Pharmaceutical Society has established four principles of medicines optimisation that healthcare professionals should follow. Read More

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http://dx.doi.org/10.7748/ns.2020.e11479DOI Listing
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