27,030 results match your criteria Adjustment Disorders


A fully adjusted two-stage procedure for rank-normalization in genetic association studies.

Genet Epidemiol 2019 Jan 17. Epub 2019 Jan 17.

Department of Biostatistics, University of Washington, Seattle, Washington.

When testing genotype-phenotype associations using linear regression, departure of the trait distribution from normality can impact both Type I error rate control and statistical power, with worse consequences for rarer variants. Because genotypes are expected to have small effects (if any) investigators now routinely use a two-stage method, in which they first regress the trait on covariates, obtain residuals, rank-normalize them, and then use the rank-normalized residuals in association analysis with the genotypes. Potential confounding signals are assumed to be removed at the first stage, so in practice, no further adjustment is done in the second stage. Read More

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http://dx.doi.org/10.1002/gepi.22188DOI Listing
January 2019

Cardiometabolic disease, depressive symptoms, and sleep disorders in middle-aged adults with functional disabilities: NHANES 2007-2014.

Disabil Rehabil 2019 Jan 17:1-6. Epub 2019 Jan 17.

a Department of Physical Medicine and Rehabilitation , University of Michigan , Ann Arbor , MI , USA.

Purpose: This study examined whether depressive symptoms and sleep disorders modified the association between functional disabilities and cardiometabolic disease profiles in middle-aged adults (40-64 years).

Methods: Participants came from the 2007-2014 NHANES. Information regarding cardiometabolic diseases, demographics, depressive symptoms, and sleep disorders were obtained. Read More

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http://dx.doi.org/10.1080/09638288.2018.1555720DOI Listing
January 2019

Characteristics of neighborhood environment (social cohesion and safety) and common mental disorders in ELSA-Brasil study: a multilevel analysis.

Cad Saude Publica 2019 10;35(1):e00197017. Epub 2019 Jan 10.

Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

The purpose of this study was to determine if self-reported characteristics of social cohesion and local neighborhood safety positively affect the mental health of their residents, regardless of individual characteristics. A sample of participants in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline was used. The Clinical Interview Schedule-Revised (CIS-R) instrument was used for tracking common mental disorders (CMD). Read More

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http://dx.doi.org/10.1590/0102-311x00197017DOI Listing
January 2019

Association between antidepressant use during pregnancy and autism spectrum disorder in children: a retrospective cohort study based on Japanese claims data.

Matern Health Neonatol Perinatol 2019 10;5. Epub 2019 Jan 10.

1Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Yoshidakonoe-cho Sakyo-ku, Kyoto, 606-8501 Japan.

Background: Studies using data from Western countries have raised concerns that treating pregnant women with antidepressants may increase the risk of autism spectrum disorders (ASDs) in their offspring. However, to date, the studies are inconclusive. We therefore examined the association between antidepressant use and ASD using claims data collected in Japan. Read More

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http://dx.doi.org/10.1186/s40748-018-0096-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327597PMC
January 2019

Mental disorders and the risk of adult violent and psychological victimisation: a prospective, population-based study.

Epidemiol Psychiatr Sci 2019 Jan 17:1-10. Epub 2019 Jan 17.

Department of Psychiatry,Amsterdam UMC/GGZ inGeest,P.O. Box 7057, 1007 MB Amsterdam,The Netherlands.

AimsPsychiatric patients are at increased risk to become victim of violence. It remains unknown whether subjects of the general population with mental disorders are at risk of victimisation as well. In addition, it remains unclear whether the risk of victimisation differs across specific disorders. Read More

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http://dx.doi.org/10.1017/S2045796018000768DOI Listing
January 2019

Relationships Between Biochemical Markers of Hyperandrogenism and Metabolic Parameters in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.

Horm Metab Res 2019 Jan 16;51(1):22-34. Epub 2019 Jan 16.

Endocrinology Unit, Department of Health Sciences and Mother and Child Care, University of Palermo, Palermo, Italy.

While several studies have documented an increased risk of metabolic disorders in patients with polycystic ovary syndrome (PCOS), associations between androgenic and metabolic parameters in these patients are unclear. We aimed to investigate the relationships between biochemical markers of hyperandrogenism (HA) and metabolic parameters in women with PCOS. In this systematic review and meta-analysis, a literature search was performed in the PubMed, Scopus, Google Scholar, ScienceDirect, and Web of Science from 2000 to 2018 for assessing androgenic and metabolic parameters in PCOS patients. Read More

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http://dx.doi.org/10.1055/a-0806-8281DOI Listing
January 2019

Vitamin D serum concentration is not related to the activity of spondyloarthritis - preliminary study.

Reumatologia 2018 23;56(6):388-391. Epub 2018 Dec 23.

Department of Rheumatology and Balneology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland.

Objective: Vitamin D plays an important role in mineral turnover and bone remodeling and there are increasing data about its immunomodulatory potential in different rheumatologic disorders. Deficiency of vitamin D is frequent in patients with spondyloarthritis (SpA) and some data suggest its association with increased disease activity and structural damage. However, its exact role in the pathogenesis of SpA and its association with disease activity are still a matter of debate. Read More

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http://dx.doi.org/10.5114/reum.2018.80717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330676PMC
December 2018

Association of Elective and Emergency Cesarean Delivery With Early Childhood Overweight at 12 Months of Age.

JAMA Netw Open 2018 Nov 2;1(7):e185025. Epub 2018 Nov 2.

Duke-NUS Medical School, Singapore, Singapore.

Importance: Global cesarean delivery (CD) rates have more than doubled over the past 2 decades, with an increasing contribution from elective CDs. Cesarean delivery has been linked to early childhood overweight and obesity, but limited studies have examined elective and emergency CDs separately.

Objective: To investigate whether elective or emergency CD was associated with risk of early childhood overweight. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.5025DOI Listing
November 2018
1 Read

Association of Food Allergy and Other Allergic Conditions With Autism Spectrum Disorder in Children.

JAMA Netw Open 2018 Jun 1;1(2):e180279. Epub 2018 Jun 1.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City.

Importance: The prevalence of autism spectrum disorder (ASD) in US children has increased during the past decades. Immunologic dysfunction has recently emerged as a factor associated with ASD. Although children with ASD are more likely to have gastrointestinal disorders, little is known about the association between food allergy and ASD. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.0279DOI Listing

Risk Factor Genes in Patients with Dystonia: A Comprehensive Review.

Tremor Other Hyperkinet Mov (N Y) 2018 9;8:559. Epub 2019 Jan 9.

Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, GR.

Background: Dystonia is a movement disorder with high heterogeneity regarding phenotypic appearance and etiology that occurs in both sporadic and familial forms. The etiology of the disease remains unknown. However, there is increasing evidence suggesting that a small number of gene alterations may lead to dystonia. Read More

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http://dx.doi.org/10.7916/D8H438GSDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329780PMC
January 2019

Postural control after unexpected external perturbation: Effects of Parkinson's disease subtype.

Hum Mov Sci 2019 Jan 9;64:12-18. Epub 2019 Jan 9.

São Paulo State University (Unesp), Institute of Biosciences, Posture and Gait Studies Laboratory (LEPLO), Rio Claro, Brazil; Post-Graduation Program in Movement Sciences, São Paulo State University - UNESP, Brazil. Electronic address:

Different clinical subtypes of Parkinson's disease (PD) have long been recognized. Recent studies have focused on two PD subtypes: Postural Instability and Gait Difficulty (PIGD) and Tremor Dominant (TD). PIGD patients have greater difficulties in postural control in relation to TD. Read More

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http://dx.doi.org/10.1016/j.humov.2019.01.001DOI Listing
January 2019

Effort valuation and psychopathology in children and adults.

Psychol Med 2019 Jan 14:1-7. Epub 2019 Jan 14.

Department of Psychiatry and Behavioral Sciences,State University of New York - Upstate Medical University,Syracuse,New York,USA.

Background: The Research Domain Criteria initiative was launched by the US National Institute of Mental Health to establish a multi-level framework for understanding psychological constructs relevant to human psychiatric disorders, and identified 'effort valuation/willingness to work' as a clinically useful construct worthy of further study. This construct encompasses the processes by which the cost(s) of obtaining an outcome are calculated, and the tendency to overcome response costs to obtain a reinforcer. The current study aims to examine effort valuation as a correlate of psychopathology in children and adults, and the moderating effects of sex on this relationship. Read More

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http://dx.doi.org/10.1017/S0033291718003884DOI Listing
January 2019
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Prognostic Value of BRAF and KRAS Mutation in Relation to Colorectal Cancer Survival in Iranian Patients: Correlated to Microsatellite Instability.

J Gastrointest Cancer 2019 Jan 12. Epub 2019 Jan 12.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Erabi Ave, P.O. Box 1985717413, Tehran, Velenjak, Iran.

Purpose: To evaluate the prognostic role of BRAF and KRAS mutations after adjustment for microsatellite instability (MSI) in Iranian colorectal cancer (CRC) patients.

Methods: BRAF and KRAS mutations and MSI status were assessed in 258 Iranian subjects with CRC. Two hundred fifty-eight consecutive stages I-IV CRC patients, who underwent surgical resection of adenocarcinoma from 2012 to 2016, were enrolled in the research. Read More

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http://dx.doi.org/10.1007/s12029-019-00201-4DOI Listing
January 2019

A review of the effect of faecal incontinence and constipation on sexual function.

Int J Colorectal Dis 2019 Jan 11. Epub 2019 Jan 11.

The Sir Alan Parks Department of Physiology, St Mark's Hospital and Academic Institute, Watford Road, Harrow, HA1 3UJ, UK.

Aim: Faecal incontinence and constipation are common conditions which may adversely affect quality of life. They may have an adverse effect on sexual function.

Method: This review of the published literature aimed to assess the published evidence. Read More

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http://dx.doi.org/10.1007/s00384-018-03231-9DOI Listing
January 2019

Association of Gestational Diabetes Mellitus With Neonatal Respiratory Morbidity.

Obstet Gynecol 2019 Jan 8. Epub 2019 Jan 8.

Brown University, Providence, Rhode Island; Dartmouth College, Lebanon, New Hampshire; the George Washington University Biostatistics Center, Washington, DC; Columbia University, New York, New York; the University of Texas Health Science Center at Children's Memorial Hermann Hospital, Houston, Texas; the University of Alabama at Birmingham, Birmingham, Alabama; the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland; Emory University, Atlanta, Georgia; the University of Texas Medical Branch, Galveston, Texas; The Ohio State University, Columbus, Ohio; the University of Utah Health Sciences Center, Salt Lake City, Utah; the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio; Northwestern University, Chicago, Illinois; Duke University, Durham, North Carolina; Stanford University, Stanford, California; the University of Texas Southwestern Medical Center, Dallas, Texas; University of Pittsburgh, Pittsburgh, Pennsylvania; Oregon Health and Science University, Portland, Oregon; and Wayne State University, Detroit, Michigan.

Objective: To assess neonatal respiratory morbidity in pregnancies with and without gestational diabetes mellitus (GDM) at imminent risk of late preterm delivery in a modern U.S. cohort. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003053DOI Listing
January 2019

Diurnal variability of cerebral metabolites in healthy human brain with 2D localized correlation spectroscopy (2D L-COSY).

J Magn Reson Imaging 2019 Jan 10. Epub 2019 Jan 10.

School of Health Sciences, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia.

Background: Two-dimensional localized correlation spectroscopy (2D L-COSY) is a research tool that has been applied to evaluate in vivo metabolic activity in many neurological and oncological disorders. Circadian mediators such as brain temperature, hydration, and osmotic regulation have been claimed to change metabolic profiles.

Purpose: To evaluate the diurnal variability of neuro-metabolites with 2D L-COSY in healthy subjects using a 3 T scanner. Read More

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http://dx.doi.org/10.1002/jmri.26642DOI Listing
January 2019
3.210 Impact Factor

Postpartum Health Care Use After Gestational Diabetes and Hypertensive Disorders of Pregnancy.

J Womens Health (Larchmt) 2019 Jan 10. Epub 2019 Jan 10.

1 Agency for Healthcare Research and Quality, Rockville, Maryland.

Objective: To examine postpartum health care utilization after a pregnancy complicated by gestational diabetes (GD) and hypertensive disorders of pregnancy (HDP) using nationally representative data.

Materials And Methods: We examined longitudinal pooled panel data from the 1996-2007 Medical Expenditure Panel Survey with linked data from Pregnancy Detail Files on adult women (>18) with singleton pregnancies who reported an infant delivery. Multivariable weighted logistic regression analyses, including interactions, examined the associations between pregnancy complications (GD/HDP) and three postpartum health care utilization outcomes, adjusting for demographic characteristics. Read More

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http://dx.doi.org/10.1089/jwh.2018.7198DOI Listing
January 2019

Associations between sleep and obesity indices in older adults: results from the HELIAD study.

Aging Clin Exp Res 2019 Jan 9. Epub 2019 Jan 9.

Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.

Background: Short sleep duration and low sleep quality are negatively associated with obesity in young adults, but in older people the results are inconsistent.

Aims: The aim of the present study was to examine the associations between sleep duration and quality with both body mass index (BMI) and waist circumference (WC) and to investigate sex- and age-specific associations in a population-representative cohort of older adults.

Methods: 1781 participants ≥ 65 years old from the HELIAD study were included. Read More

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http://link.springer.com/10.1007/s40520-018-01113-2
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http://dx.doi.org/10.1007/s40520-018-01113-2DOI Listing
January 2019
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Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy.

Environ Health 2019 Jan 9;18(1). Epub 2019 Jan 9.

Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China.

Background: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) have been reported to disrupt endocrine system and reproduction. However, epidemiological evidence on the association between PFAS and preeclampsia is inconsistent. We aimed to investigate the association between prenatal PFAS exposure and hypertensive disorders of pregnancy (HDP) in humans. Read More

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https://ehjournal.biomedcentral.com/articles/10.1186/s12940-
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http://dx.doi.org/10.1186/s12940-018-0445-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327470PMC
January 2019
2 Reads

Increased incidence of obstetric and perinatal complications in pregnancies achieved using donor oocytes and single embryo transfer in young and healthy women. A prospective hospital-based matched cohort study.

Gynecol Endocrinol 2019 Jan 9:1-6. Epub 2019 Jan 9.

e Department of Clinical Science, Intervention and Technology , Karolinska Institutet , Stockholm , Sweden.

In this single-center matched-cohort study, women who underwent IVF/ICSI with donor oocytes between 2007 and 2014 (n = 259) were compared to women undergoing autologous cycles during the same time period (n = 515). The matching (1:2) took into consideration the women's age, type of treatment (IVF/ICSI), and year of embryo transfer. All women were healthy and below 40 years of age at the time of IVF/ICSI, and the treatments were performed using a strict policy of single embryo transfer. Read More

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http://dx.doi.org/10.1080/09513590.2018.1528577DOI Listing
January 2019

Coping, Mood, Quality of Life and Outcomes in Recipients of Left Ventricular Assist Devices: a Cluster Analysis.

Psychosom Med 2018 Dec 4. Epub 2018 Dec 4.

From IRCCS Fondazione Don Carlo Gnocchi, Santa Maria Nascente Cardiac Rehabilitation (Modica, Minotti, Scaglione, Bordoni, Racca, Ferratini), Milan, Italy and CNR Clinical Physiology Institute (De Maria), Heart Failure Heart Transplant Program Cardiology (Cipriani) and Cardiac Surgery (Russo), Cardiothoracic and Vascular Department, ASST - Great Metropolitan Hospital Niguarda, Milan, Italy.

Objectives: Left Ventricular Assist Devices (LVAD) are increasingly used for temporary circulatory support until transplant or as destination therapy (DT) for patients with end-stage Heart failure (HF). Understanding patients' attitudes and resources is crucial to support them.

Methods: Sixty-one LVAD recipients (55±10 years, 10% women, 15% DT) participating in cardiac rehabilitation (CR) post-implant underwent assessment of coping styles (COPE), quality of life (Medical Outcomes Study Short Form 36, Minnesota Living with Heart Failure Questionnaire) and mood (Hospital Anxiety and Depression Scale). Read More

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http://dx.doi.org/10.1097/PSY.0000000000000658DOI Listing
December 2018
3.473 Impact Factor

Efficacy of psychotherapy for bulimia nervosa and binge-eating disorder on self-esteem improvement: Meta-analysis.

Eur Eat Disord Rev 2019 Jan 9. Epub 2019 Jan 9.

School of Psychology, Deakin University, Geelong, Victoria, Australia.

Objectives: This meta-analysis examined the effects of psychotherapy for bulimia nervosa (BN) and binge-eating disorder (BED) on self-esteem improvement.

Method: Randomized controlled trials (RCTs) of psychological treatments that assessed self-esteem change in eating disorders were included. Thirty-four RCTs were included; most sampled BED and then BN. Read More

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http://dx.doi.org/10.1002/erv.2662DOI Listing
January 2019

Association between Eating Speed and Classical Cardiovascular Risk Factors: A Cross-Sectional Study.

Nutrients 2019 Jan 4;11(1). Epub 2019 Jan 4.

Department of Biochemistry and Biotechnology, Human Nutrition Unit, Universitat Rovira i Virgili, Institut d'Investigació Sanitària Pere i Virgili (IISPV), Hospital Universitati Sant Joan de Reus, Reus 43201, Spain.

Cardiovascular disease (CVD) is one of the main causes of morbidity and mortality around the world. Lifestyle is recognized as a key factor in the development of metabolic disorders and CVD. Recently, eating speed has been of particular interest since some studies have associated it with the development of obesity and other cardiometabolic disorders. Read More

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http://www.mdpi.com/2072-6643/11/1/83
Publisher Site
http://dx.doi.org/10.3390/nu11010083DOI Listing
January 2019
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Association Between Appetite and Sarcopenia in Patients With Mild Cognitive Impairment and Early-Stage Alzheimer's Disease: A Case-Control Study.

Front Nutr 2018 18;5:128. Epub 2018 Dec 18.

Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Obu, Japan.

Sarcopenia is frequently seen in patients with mild cognitive impairment (MCI) and early-stage Alzheimer's disease (AD). While appetite loss and physical inactivity, which are also frequently seen in dementia, appear to contribute to sarcopenia, to date, no study has investigated this association. The aim of this study was to examine factors associated with sarcopenia, including appetite and physical activity, in patients with MCI and early-stage AD. Read More

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http://dx.doi.org/10.3389/fnut.2018.00128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305366PMC
December 2018

Effect of Genotype and Maternal Affective Disorder on Intronic Methylation of FK506 Binding Protein 5 in Cord Blood DNA.

Front Genet 2018 17;9:648. Epub 2018 Dec 17.

Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States.

A single nucleotide polymorphism (SNP: rs1360780) in has been shown to interact with exposure to childhood adversity to promote loss of methylation and increase in gene expression in adults. We asked whether rs1360780 can influence intronic methylation in the context of exposure to maternal affective disorders . Sixty cord blood DNA samples from the Boston Birth Cohort were genotyped at rs1360780 and studied for methylation changes as they relate to genotype and exposure to affective disorders during pregnancy. Read More

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http://dx.doi.org/10.3389/fgene.2018.00648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305129PMC
December 2018
1 Read

The impact of extending the second stage of labor to prevent primary cesarean section on maternal and neonatal outcomes.

Am J Obstet Gynecol 2018 Oct 25. Epub 2018 Oct 25.

Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel; Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. Electronic address:

Background: A low rate of primary cesarean delivery is expected to reduce some of the major complications that are associated with a repeat cesarean delivery such as uterine rupture, adhesive placental disorders, hysterectomy and even maternal death. Since 2014, and in alignment with the American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine, we changed our approach to labor dystocia, defined as abnormal progression of labor, by allowing a longer duration of the second stage of labor.

Objective: To examine the effect of prolonging the second stage of labor on the rate of cesarean delivery, and maternal and neonatal outcomes. Read More

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http://dx.doi.org/10.1016/j.ajog.2018.10.028DOI Listing
October 2018

A comparative study evaluating the marital and sexual functioning in patients with schizophrenia and depressive disorders.

Asian J Psychiatr 2018 Dec 29;39:128-134. Epub 2018 Dec 29.

Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Aim: To assess marital functioning, quality of marriage, marital forgiveness, sexual dysfunction and sexual satisfaction among patients with schizophrenia and their spouses and compare the same with patients with depressive disorder and their spouses.

Methodology: 76 married patients with schizophrenia and 58 married patients with depressive disorders were assessed on Dyadic Adjustment Scale (DAS), Quality Marriage Index (QMI), Marital Forgiveness Scale (MOFS), Arizona Sexual Experience Questionnaire (ASEX) and New Sexual Satisfaction Scale (NSSS).

Results: Compared to patients with depressive disorder, patients with schizophrenia reported poor marital adjustment (in the consensus and satisfaction domains of DAS) and poor quality of marriage. Read More

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http://dx.doi.org/10.1016/j.ajp.2018.12.021DOI Listing
December 2018

Premorbid adjustment trajectories in schizophrenia and bipolar disorder: A transdiagnostic cluster analysis.

Psychiatry Res 2018 Dec 31;272:655-662. Epub 2018 Dec 31.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; VISN 2 Mental Illness Research, Education, and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA; Brigham and Women's Hospital, Boston, MA, USA. Electronic address:

Despite the overlap between schizophrenia and bipolar disorder, neurodevelopmental abnormalities are thought to be associated primarily with schizophrenia. Transdiagnostic and empirical identification of subgroups based on premorbid adjustment (PMA) may enhance understanding of illness trajectories. 160 patients with bipolar I or II disorder (BD; n = 104) or schizophrenia or schizoaffective disorder (SZ; n = 56) were assessed on PMA course from childhood to late adolescence and current symptoms and functioning. Read More

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http://dx.doi.org/10.1016/j.psychres.2018.12.169DOI Listing
December 2018

Total Glycosides of Peony Protects Against Inflammatory Bowel Disease by Regulating IL-23/IL-17 Axis and Th17/Treg Balance.

Am J Chin Med 2019 Jan 7:1-25. Epub 2019 Jan 7.

† School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, P. R. China.

Inflammatory bowel disease (IBD) is a group of autoimmune diseases, including ulcerative colitis and Crohn's disease, characterized by nonspecific inflammation in the gut. Total glycoside of peony (TGP) has been widely used for treatment of autoimmune diseases because of its pharmacological effects. However, it is lack of depth in whether TGP regulate T helper 17 cell (Th17) / T regulatory cell (Treg) immune balance or interleukin 23 (IL-23) / IL-17 axis to achieve the goal of treating IBD. Read More

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https://www.worldscientific.com/doi/abs/10.1142/S0192415X195
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http://dx.doi.org/10.1142/S0192415X19500095DOI Listing
January 2019
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Upregulation of Circulating Cardiomyocyte-Enriched miR-1 and miR-133 Associate with the Risk of Coronary Artery Disease in Type 2 Diabetes Patients and Serve as Potential Biomarkers.

J Cardiovasc Transl Res 2019 Jan 4. Epub 2019 Jan 4.

Department of Molecular Medicine/Al-Jawhara Centre for Molecular Medicine, Genetics and Inherited Disorders, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain.

Circulating miRNAs are increasingly suggested as clinical biomarker for diseases. We evaluated the expression of circulating cardiomyocyte-enriched miR-1 and miR-133 by real-time PCR in blood from patients with type 2 diabetes (T2D) without and with coronary artery disease (CAD) and healthy controls, investigated their association with the risk of CAD risk and their potential as biomarkers. The two miRNAs were upregulated in patients with T2D and CAD compared with controls, associated with CAD risk and remained significant after adjustment for multiple confounders. Read More

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http://dx.doi.org/10.1007/s12265-018-9857-2DOI Listing
January 2019
1 Read

Respiratory syncytial virus prophylaxis in infants with congenital airway anomalies compared to standard indications and complex medical disorders.

Eur J Pediatr 2019 Jan 4. Epub 2019 Jan 4.

Medical Outcomes and Research in Economics (MORE®) Research Group, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

An observational study was conducted of children < 2 years who received ≥ 1 dose of palivizumab in 32 Canadian institutions from 2005 to 2017. We compared respiratory illness (RIH) and respiratory syncytial virus-related hospitalization (RSVH) hazards in children with a congenital airway anomaly (CAA) versus those prophylaxed for standard indications (SI) and serious medical disorders (SMD). Data were assembled on neonatal course, demographics, palivizumab utilization and adherence, and respiratory illness events, and analyzed using ANOVA, chi-square tests and Cox proportional hazards. Read More

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http://link.springer.com/10.1007/s00431-018-03308-1
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http://dx.doi.org/10.1007/s00431-018-03308-1DOI Listing
January 2019
1 Read

Differences in prevalence and associated factors between mild and severe vertebral fractures in Japanese men and women: the third survey of the ROAD study.

J Bone Miner Metab 2019 Jan 3. Epub 2019 Jan 3.

Department of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center, The University of Tokyo Hospital, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.

Vertebral fracture (VF) is a common osteoporotic fracture, while its epidemiology varies according to regions and ethnicities, little is known about it in Japan. Using whole-spine radiographs from a population-based cohort study, the Research on Osteoarthritis/Osteoporosis Against Disability study 3rd survey performed in 2012-2013, we estimated the sex- and age-specific prevalence of VF in the Japanese. Genant's semiquantitative method (SQ) was used to define VF; SQ ≥ 1 as VF, SQ = 1 as mild VF, SQ≥ 2 as severe VF. Read More

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http://link.springer.com/10.1007/s00774-018-0981-5
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http://dx.doi.org/10.1007/s00774-018-0981-5DOI Listing
January 2019
5 Reads

The Association between Dietary Vitamin C/E and Gestational Hypertensive Disorder: A Case-Control Study.

J Nutr Sci Vitaminol (Tokyo) 2018 ;64(6):454-465

Department of Gynecology and Obstetrics of Gansu Provincial Maternity and Child-care Hospital.

A case-control study of 10,228 gestational women was conducted in Lanzhou, China, between 2010 and 2012. This study aimed to evaluate the associations between the risk of gestational hypertensive disorders and dietary intake of vitamin C/E. Among this study's participants, 5. Read More

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http://dx.doi.org/10.3177/jnsv.64.454DOI Listing
January 2018
1 Read

Association of circulating 25-hydroxyvitamin D and parathyroid hormone with carotid intima media thickness in children and adolescents with excess weight.

J Steroid Biochem Mol Biol 2018 Dec 31. Epub 2018 Dec 31.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Evidence on the association of vitamin D and parathyroid hormone (PTH) with cardiovascular risk factors in the young is limited. We therefore assessed the relationships of circulating vitamin D and PTH concentrations and subclinical atherosclerosis in overweight or obese children and adolescents. This was a cross-sectional study, investigated the association of 25-hydroxyvitamin D (25(OH)D), intact PTH (iPTH), and iPTH/25(OH)D ratio with carotid intima-media thickness (cIMT) in 368 Iranian children and adolescents with a body mass index (BMI) ≥1 z-score based on WHO criteria. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2018.12.015DOI Listing
December 2018

[Prevalence of psychiatric disorders in a population candidate for obesity surgery: Experience in psychiatric assessment in a public hospital within a multidisciplinary morbid obesity treatment team].

Vertex 2018 Mar;29(138):133-138

Equipo de Trastorno Alimentarios y Obesidades del Servicio de Salud Mental del Hospital General de Agudos Dr. C. Durand. Ciudad Autónoma de Buenos Aires. Programa de Unidades Bariátricas (PUBA).

Currently, obesity has become one of the greatest concerns of global health since it is associated with a signifcant increase in population morbidity and mortality. Specifcally for severe obesity (BMI> to 40) treatments that include bariatric surgeries have shown greater effcacy in the long term outcomes. This article presents the prevalence of psychiatric disorders observed in the pre-surgical assessment of 968 candidates from a multidisciplinary team of a public hospital in the city of Buenos Aires during the period 2006 to 2011. Read More

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March 2018
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Increased risk of type 2 diabetes among the siblings of patients with schizophrenia.

CNS Spectr 2019 Jan 3:1-7. Epub 2019 Jan 3.

4Department of Family Medicine,Taipei Veterans General Hospital,Taipei,Taiwan.

Background: Research suggests an association between metabolic disorders, such as type 2 diabetes mellitus (T2DM), and schizophrenia. However, the risk of metabolic disorders in the unaffected siblings of patients with schizophrenia remains unclear.

Methods: Using the Taiwan National Health Insurance Research Database, 3135 unaffected siblings of schizophrenia probands and 12,540 age-/sex-matched control subjects were included and followed up to the end of 2011. Read More

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http://dx.doi.org/10.1017/S1092852918001396DOI Listing
January 2019
4 Reads
2.710 Impact Factor

Reaction to Severe Stress and Adjustment Disorders After the September 2017 Earthquakes in a Psychiatric Emergency Department in Mexico City.

Disaster Med Public Health Prep 2019 Jan 3:1-5. Epub 2019 Jan 3.

6Continuous Psychiatric Care Department,National Institute of Psychiatry Ramón de la Fuente,Mexico City,Mexico.

Objective: Earthquakes may lead to a reaction to severe stress and adjustment disorders (RSSAD). On September 7, 19, and 23, 2017, Mexico was struck by many severe earthquakes. The aim of this study was to examine whether there was an increase in the number of consultations and RSSAD in a psychiatric emergency department in Mexico City after these earthquakes. Read More

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http://dx.doi.org/10.1017/dmp.2018.136DOI Listing
January 2019
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Association of brain heptachlor epoxide and other organochlorine compounds with lewy pathology.

Mov Disord 2018 Dec 30. Epub 2018 Dec 30.

Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii, USA.

Background: Organochlorine pesticides are associated with an increased risk of Parkinson's disease. A preliminary analysis from the Honolulu-Asia Aging Study suggested that heptachlor epoxide, a metabolite from an organochlorine pesticide extensively used in Hawaii, may be especially important. This was a cross sectional analysis to evaluate the association of heptachlor epoxide and other organochlorine compounds with Lewy pathology in an expanded survey of brain organochlorine residues from the longitudinal Honolulu-Asia Aging Study. Read More

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http://dx.doi.org/10.1002/mds.27594DOI Listing
December 2018

Positive Mental Attitude Associated with Lower 35-Year Mortality: The Leisure World Cohort Study.

J Aging Res 2018 25;2018:2126368. Epub 2018 Nov 25.

Department of Neurology, School of Medicine, University of California, Irvine, California, USA.

Background: Although emerging research has suggested that "positive psychological well-being" is associated with better health outcomes, studies of long-term health and mortality in the elderly are limited. This study assessed the relationship of mental attitude and mortality in older adults followed up for 35 years.

Methods: In the 1980s, the Leisure World Cohort Study recruited residents of a California retirement community to a prospective cohort study of health promotion and disease prevention. Read More

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http://dx.doi.org/10.1155/2018/2126368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286774PMC
November 2018

Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps.

Biol Psychiatry 2018 Nov 29. Epub 2018 Nov 29.

Department of Psychiatry, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.

Background: Error processing and inhibitory control enable the adjustment of behaviors to meet task demands. Functional magnetic resonance imaging studies report brain activation abnormalities in patients with obsessive-compulsive disorder (OCD) during both processes. However, conclusions are limited by inconsistencies in the literature and small sample sizes. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.11.010DOI Listing
November 2018
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Effect of Low versus High Frequency Subthalamic Deep Brain Stimulation on Speech Intelligibility and Verbal Fluency in Parkinson's Disease: A Double-Blind Study.

J Parkinsons Dis 2018 Dec 28. Epub 2018 Dec 28.

Sobell Department of Motor Neuroscience and Movement Disorders, Unit of Functional Neurosurgery, National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.

Background: Subthalamic deep brain stimulation (STN-DBS) is an established treatment for late stage Parkinson's disease (PD). Speech intelligibility (SI) and verbal fluency (VF) have been shown to deteriorate following chronic STN-DBS. It has been suggested that speech might respond favourably to low frequency stimulation (LFS). Read More

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http://dx.doi.org/10.3233/JPD-181368DOI Listing
December 2018

Comments on "Affective instability in those with and without mental disorders: A case control study" by Marwaha et al.

J Affect Disord 2018 Dec 21;246:327-328. Epub 2018 Dec 21.

School of Medicine, Universidad Peruana de Ciencias Aplicadas, Alameda San Marcos cuadra 2, Chorrillos, Lima, Perú.

This letter has the purpose to comment the article by Marwaha et al. regarding affective instability and mental disorders. We wish to highlight the importance to report the proper measures of association in case-control studies, and the impact of adjusting the results when finding associations with possible confounders in the bivariate analysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183289
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http://dx.doi.org/10.1016/j.jad.2018.12.061DOI Listing
December 2018
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Attributable risk of hospital admissions for overall and specific mental disorders due to particulate matter pollution: A time-series study in Chengdu, China.

Environ Res 2018 Dec 12;170:230-237. Epub 2018 Dec 12.

Health and Family Planning Information Center of Sichuan Province, Chengdu 610041, Sichuan, China. Electronic address:

The associations of particulate matter (PM) pollution with the morbidity of overall and subtypes of mental disorders (MDs), as well as the corresponding morbidity burden, remain understudied, especially in developing countries. This study aimed to evaluate the short-term effects of PM (diameters ≤ 2.5 µm), PM (diameters ≤ 10 µm) and PM (diameters between 2. Read More

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http://dx.doi.org/10.1016/j.envres.2018.12.019DOI Listing
December 2018
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Implementation of intraoperative computed tomography for deep brain stimulation: pitfalls and optimization of workflow, accuracy, and radiation exposure.

World Neurosurg 2018 Dec 26. Epub 2018 Dec 26.

Department of Neurosurgery, University Marburg, Marburg, Germany; Marburg Center for Mind, Brain and Behavior (MCMBB), Marburg, Germany.

Objective: Deep brain stimulation (DBS) is an effective treatment for movement disorders. Stereotactic electrode placement can be guided by intraoperative imaging, which also allows an immediate intraoperative quality control. This paper is about implementation and refining a workflow applying intraoperative computed tomography (iCT) for DBS. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.079DOI Listing
December 2018

Why Should Psychiatrists and Neuroscientists Worry about Paraoxonase 1?

Curr Neuropharmacol 2018 Dec 27. Epub 2018 Dec 27.

Department of Psychiatry, Medical University of Plovdiv, Plovdiv. Bulgaria.

Background: Nitro-oxidative stress (NOS) has been implicated in the pathophysiology of psychiatric disorders. The activity of the polymorphic antioxidant enzyme paraoxonase 1 (PON1) is altered in diseases where NOS is involved. PON1 activity may be estimated using different substrates some of which are influenced by PON1 polymorphisms. Read More

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http://dx.doi.org/10.2174/1570159X17666181227164947DOI Listing
December 2018
3 Reads

Resilience in children and their parents enduring paediatric medical traumatic stress.

Paediatr Anaesth 2018 Dec 27. Epub 2018 Dec 27.

Department of Anaesthesiology and Intensive Care, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

Due to the general lack of familiarity with the concept in the medical field, resilience is rarely considered in paediatric medical traumas. Resilience is an ability that enables recovery after adversities such as traumas, surgeries, serious health problems or social issues. Stress from medical traumas encompasses both the psychological and physical responses of children and their families. Read More

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http://dx.doi.org/10.1111/pan.13573DOI Listing
December 2018

Coping styles and symptomatic manifestation of first-episode psychosis: Focus on cognitive performance.

Psychiatry Res 2018 Dec 18;272:246-251. Epub 2018 Dec 18.

Department of Genetics, Wroclaw Medical University, Marcinkowskiego 1 Street, 50-368 Wroclaw, Poland. Electronic address:

Cognitive deficits are widely observed in patients with psychosis and represent one of most important determinants of functional outcomes. It has been shown that patients with psychosis prefer maladaptive coping strategies over active coping styles. However, it remains unknown whether cognitive impairments are related to coping styles in psychotic disorders. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01651781183143
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http://dx.doi.org/10.1016/j.psychres.2018.12.083DOI Listing
December 2018
2 Reads

Association Between Sleep Apnea and Blood Pressure Control Among Blacks: Jackson Heart Sleep Study.

Circulation 2018 Dec 10. Epub 2018 Dec 10.

Brigham and Women's Hospital, Boston, MA.

Background: Blacks have a high prevalence of hypertension and uncontrolled blood pressure (BP), each of which may be partially explained by untreated sleep apnea. We investigated the association of sleep apnea with uncontrolled BP and resistant hypertension in blacks.

Methods: Between 2012 and 2016, Jackson Heart Sleep Study participants (N=913) underwent an in-home Type 3 sleep apnea study, clinic BP measurements, and anthropometry. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036675DOI Listing
December 2018
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The role of self-esteem in Internet addiction within the context of comorbid mental disorders: Findings from a general population-based sample.

J Behav Addict 2018 Dec 26;7(4):976-984. Epub 2018 Dec 26.

1 Department of Psychiatry and Psychotherapy, University of Lübeck , Lübeck, Germany.

Background And Aims: Internet Addiction (IA) has consistently been related to comorbid psychiatric disorders and lowered self-esteem. However, most studies relied on self-report questionnaires using non-representative samples. This study aims to analyze the relative impact of self-esteem and comorbid psychopathology with lifetime IA in a population-based sample of excessive Internet users using clinical diagnoses assessed in a personal interview. Read More

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https://www.akademiai.com/doi/10.1556/2006.7.2018.130
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http://dx.doi.org/10.1556/2006.7.2018.130DOI Listing
December 2018
1 Read

[Acupuncture and Moxibustion and Immunity: the Actuality and Future].

Zhen Ci Yan Jiu 2018 Dec;43(12):747-53

College of Acupuncture-moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.

Immunity reaction has been regarded as a key step for clinical acupuncture and moxibustion treatment. In the present paper, we review current situations about studies on acupuncture-moxibustion induced immunoregulation from 1) related project fundings of National Natural Science Foundation (NCFS) of China from 1989-2017; 2) papers published in SCI and Chinese medical journals from 2010-2018; 3) clinical conditions or disorders treated by acupuncture and moxibustion and their clinical therapeutic effects; 4) the commonly used acupoints for studying immune regulation functions; 5) some mechanisms of innate immunity and adaptive immunity involved; and 6) immune adjustment pathways involved. Moreover, in our future studies, we suggest to pay more attention to 1) the detailed cellular molecular mechanisms; 2) interactions among the immune cells, the immune cells and non-immune cells and cytokines responsible for regulation effects of acupuncture-moxibustion; 3) interrelationship of different systems as skin-brain axis, brain-intestinal axis, nerve-blood vessel unit of brain tissues, etc. Read More

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http://dx.doi.org/10.13702/j.1000-0607.180623DOI Listing
December 2018
3 Reads