27,241 results match your criteria Adjustment Disorders


Optical Coherence Tomography Angiography of a Pale Optic Disc in Demyelinating Optic Neuritis and Ischemic Optic Neuropathy.

J Neuroophthalmol 2019 Mar 18. Epub 2019 Mar 18.

Farabi Eye Hospital (MAF, SY, HG, SM), Eye Research Center, Department of Ophthalmology, Tehran University of Medical Science, Tehran, Iran; Department of Ophthalmology (RSM), Rasht University of Medical Science, Rasht, Iran; and Department of Ophthalmology, Neurology, and Neurosurgery (PSS), University of Colorado School of Medicine, Aurora, Colorado.

Background: In the setting of a pale optic disc, distinguishing a previous episode of optic neuritis (ON) from that of nonarteritic anterior ischemic optic neuropathy (NAION) may be difficult on clinical examination. Differences in peripapillary vascular network structures, if present, might be of diagnostic utility.

Methods: Thirty-five eyes with demyelinating ON, 33 eyes with NAION, and 81 eyes of normal subjects were imaged with optical coherence tomography angiography (OCT-A) to assess peripapillary vascular density (VD). Read More

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http://dx.doi.org/10.1097/WNO.0000000000000775DOI Listing

Direct effect of common mental disorders on xerostomia in adults estimated by marginal structural models: A population-based study.

Community Dent Oral Epidemiol 2019 Mar 20. Epub 2019 Mar 20.

School of Dentistry and Oral Health, Griffith University, Southport, Queensland, Australia.

Objective: To investigate the controlled direct effect (CDE) of common mental disorders (CMD) on xerostomia which is not mediated by psychoactive medication intake.

Methods: A population-based cross-sectional study was conducted with 1720 individuals aged 20-59 years from Florianópolis, Brazil, in 2009. A two-stage cluster sample design was adopted, with a systematic selection of census tracts, followed by a random selection of households. Read More

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http://dx.doi.org/10.1111/cdoe.12454DOI Listing

The behavioural inhibition system, behavioural activation system and experiential avoidance as explanatory variables of comorbid chronic pain and posttraumatic stress symptoms.

Eur J Psychotraumatol 2019 11;10(1):1581013. Epub 2019 Mar 11.

Facultad de Psicología, Instituto de Investigaciones Biomédicas (IBIMA), Universidad de Málaga, Málaga, Spain.

: The variables that underlie comorbid chronic pain and posttraumatic stress symptoms (PTSS) are not yet clearly established. : The aim of the present study was to analyse the role of the behavioural inhibition system (BIS), behavioural approach system (BAS) and experiential avoidance (EA) in pain adjustment (i.e. Read More

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http://dx.doi.org/10.1080/20008198.2019.1581013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419650PMC

Brief Report: Behavior Disorders and Social Skills in Adolescents with Autism Spectrum Disorder: Does IQ Matter?

J Autism Dev Disord 2019 Mar 19. Epub 2019 Mar 19.

Department of Psychology, UCLA, Los Angeles, USA.

Disruptive behavior disorders and social skills were assessed in 187 youth aged 13 years, with typical cognitive development (TD n = 98), intellectual disability (ID n = 37), autism spectrum disorder (ASD, IQ > = 85, n = 26), or Autism Spectrum Disorder with ID (ASD/ID; IQ < 85, n = 26). The primary question was whether youth with ASD and co-morbid ID had greater associated adjustment problems than youth with ASD-only. Youth with ASD, with or without ID, had significantly higher behavior problems and lower social skills than their TD peers. Read More

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http://dx.doi.org/10.1007/s10803-019-03954-wDOI Listing

Maternal pre-pregnancy weight status and health care use for mental health conditions in the offspring.

Eur Child Adolesc Psychiatry 2019 Mar 18. Epub 2019 Mar 18.

Departments of Obstetrics and Gynaecology and Pediatrics, Perinatal Epidemiology Research Unit, Dalhousie University, Halifax, NS, Canada.

The objective of this study was to examine the relationship between pre-pregnancy maternal weight status and offspring physician visits for mental health conditions in childhood and adolescence. We conducted a population-based retrospective cohort study of singleton infants born between the years of 1989 and 1993 using a linkage of the Nova Scotia Atlee Perinatal Database with administrative health data. Offspring were followed from birth to age 18 years. Read More

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http://dx.doi.org/10.1007/s00787-019-01312-wDOI Listing

Psychometric properties of Tamil version of Body Weight Image and Self Esteem questionnaire (BWISE) in severe mental illness in a South Indian population.

Asian J Psychiatr 2019 Mar 5;41:28-33. Epub 2019 Mar 5.

UCMS and GTB Hospital, Department of Psychiatry, Dilshad Garden, 110095, Delhi, India.

Background: Body weight image self-esteem questionnaire (BWISE) has been recently developed to assess psychosocial adjustment related to antipsychotic induced weight gain in Schizophrenia and related disorders. Patients have reported disturbance in body image and poor self esteem due to weight gain leading to treatment non-adherence.

Aim: Assessment of psychometric properties of Tamil version of Body weight image self-esteem questionnaire (BWISE) in our population. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.03.003DOI Listing

Strategies for Individualized Dosing of Clotting Factor Concentrates and Desmopressin in Hemophilia A and B.

Ther Drug Monit 2019 Apr;41(2):192-212

Department of Hospital Pharmacy-Clinical Pharmacology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Hemophilia A and hemophilia B are hereditary bleeding disorders, caused by a deficiency of clotting factor VIII or clotting factor IX, respectively. To treat and prevent bleedings, patients can administer clotting factor concentrates (hemophilia A and B) or desmopressin (hemophilia A). Both clotting factor concentrates and desmopressin are currently dosed according to the patients' body weight. Read More

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http://dx.doi.org/10.1097/FTD.0000000000000625DOI Listing

Association of MAPT Subhaplotypes With Risk of Progressive Supranuclear Palsy and Severity of Tau Pathology.

JAMA Neurol 2019 Mar 18. Epub 2019 Mar 18.

Department of Neuroscience, Mayo Clinic, Jacksonville, Florida.

Importance: The association between the microtubule-associated protein tau (MAPT) H1 haplotype and the risk of progressive supranuclear palsy (PSP) has been well documented. However, the specific H1 subhaplotypes that drive the association have not been evaluated in large studies, nor have they been studied in relation to neuropathologic severity of disease.

Objective: To comprehensively evaluate the associations of MAPT haplotypes with the risk of PSP and the severity of tau pathology using a large series of neuropathologically confirmed PSP cases. Read More

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http://dx.doi.org/10.1001/jamaneurol.2019.0250DOI Listing

Mental health comorbidities and cost/utilization outcomes in head and neck cancer patients.

J Psychosoc Oncol 2019 Mar 18:1-18. Epub 2019 Mar 18.

d Department of Defense , Uniformed Services University of the Health Sciences , Bethesda , Maryland , USA.

Purpose: Examine the relationship between mental health comorbidities and health services outcomes in non-elderly adults with head and neck cancer (HNC).

Design: Retrospective, cross-sectional.

Sample: Non-elderly adults with a primary diagnosis of HNC in U. Read More

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http://dx.doi.org/10.1080/07347332.2018.1519626DOI Listing

Polydrug use disorders in individuals with opioid use disorder.

Drug Alcohol Depend 2019 Feb 28;198:28-33. Epub 2019 Feb 28.

Addictions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada; Departments of Family and Community Medicine, Pharmacology and Toxicology, and Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Canada; Campbell Family Mental Health Research Institute, CAMH, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

Background: Understanding the association of polydrug use disorders (PUD) with psychosocial and clinical factors is essential for the treatment of individuals with opioid use disorder (OUD). The aim of this study is to examine whether there is an association between childhood maltreatment, mood disorders, anxiety disorders, personality disorders, or posttraumatic stress disorder (PTSD) and PUD in individuals with OUD.

Methods: We used data from 356 individuals with OUD in the past 12 months from a nationally representative database in the United States. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03768716193006
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http://dx.doi.org/10.1016/j.drugalcdep.2019.01.031DOI Listing
February 2019
4 Reads

AZATAX: Acetazolamide safety and efficacy in cerebellar syndrome in PMM2-CDG.

Ann Neurol 2019 Mar 14. Epub 2019 Mar 14.

Genetic Medicine Department and Pediatric Institute of Rare Diseases, Institut de Recerca Hospital Sant Joan de Déu Barcelona, Barcelona, Spain.

Objective: Phosphomannomutase deficiency (PMM2-CDG) causes cerebellar syndrome and stroke-like episodes (SLEs). SLEs are also described in patients with gain-of-function mutations in the CaV2.1 channel, for which acetazolamide therapy is suggested. Read More

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http://dx.doi.org/10.1002/ana.25457DOI Listing
March 2019
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Assessing whether the association between rheumatoid arthritis and schizophrenia is bidirectional: A nationwide population-based cohort study.

Sci Rep 2019 Mar 14;9(1):4493. Epub 2019 Mar 14.

Department of Psychiatry, Tzu Chi General Hospital, and School of Medicine, Tzu Chi University, Hualien, Taiwan.

Since many studies have shown a reduction in the incidence of rheumatoid arthritis (RA) in patients with schizophrenia (SCZ), little effort has been devoted to studying this link in the Asian population. Moreover, the relationship between these two disorders could be bidirectional, but the influence of RA on the SCZ incidence is unclear. The study aims to determine whether there is a bidirectional association between RA and SCZ in an Asian population. Read More

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http://dx.doi.org/10.1038/s41598-018-38149-3DOI Listing
March 2019
1 Read

Safety of levonorgestrel 52mg intrauterine system compared to copper intrauterine device: a population-based cohort study.

Contraception 2019 Mar 11. Epub 2019 Mar 11.

Univ. Bordeaux, Inserm, Bordeaux Population Health Research Centre, team PHARMACOEPIDEMIOLOGY, UMR 1219, Bordeaux, France; CHU de Bordeaux, Pôle de Santé Publique, Service de Pharmacologie Médicale, Bordeaux, France.

Objective: To compare the risk of all-cause death, hospitalizations (any cause), ectopic pregnancy, pelvic inflammatory disease or infection, uterine perforation, device removal, neuro-psychiatric drugs initiation, or new psychiatric visit(s) between levonorgestrel (LNG) 52mg intrauterine system (IUS) and copper intrauterine device (IUD) users in France.

Study Design: We identified a historical cohort of women aged 20-55years with a first dispensing of either LNG 52mg IUS or copper-IUD between January 1, 2010 and December 31, 2014, in the French National Claims database, SNDS. We used propensity score matching to balance the two groups on baseline sociodemographic and clinical characteristics to minimize confounding. Read More

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http://dx.doi.org/10.1016/j.contraception.2019.02.011DOI Listing
March 2019
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French validation of the questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS).

Parkinsonism Relat Disord 2019 Mar 4. Epub 2019 Mar 4.

Université Clermont Auvergne, NPsy-Sydo, CHRU Clermont-Ferrand, NS-Park/F-CRIN Network, Neurology Department, Clermont-Ferrand, France. Electronic address:

Introduction: The management of impulse control disorders (ICDs) in Parkinson's disease (PD) relies on their early identification, allowing adjustment of antiparkinsonian treatment before these manifestations lead to major social, financial or legal consequences. The Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) is an English-developed and -validated PD-specific rating scale constructed to support the rating of ICDs and related disorders and the assessment of changes in symptom severity over time, but it has not to date been validated in French.

Methods: We conducted an observational, multicenter, cross-sectional study among a subset of patients (n = 280) from the Drug Interacting with Genes in PD (DIG-PD) cohort, aiming to assess psychometric properties of the French version of QUIP-RS: acceptability, internal consistency, factor analysis, reproductibility and hypotheses testing. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.02.026DOI Listing
March 2019
3 Reads

Developing community-based health education strategies with family history: Assessing the association between community resident family history and interest in health education.

Soc Sci Med 2019 Feb 19. Epub 2019 Feb 19.

Richmond City Council, 900 E. Broad St., Suite 305, Richmond, VA, 23219, USA. Electronic address:

Background: Family history (FH) is an underutilized genetically informative tool that can influence disease prevention and treatment. It is unclear how FH fits into the development of community-based health education. This study examines the role that FH plays in perceived threat and health education related to mental and chronic physical conditions in the context of the health belief model. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.02.011DOI Listing
February 2019
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Remote Monitoring of Diabetes: A Cloud-Connected Digital System for Individuals With Diabetes and Their Health Care Providers.

J Diabetes Sci Technol 2019 Mar 12:1932296819834054. Epub 2019 Mar 12.

13 CERITD (Centre d'étude et de Recherche pour l'Intensification du Traitement du Diabète), Evry, Department of Diabetes, Sud-Francilien Hospital, Corbeil-Essonnes, France.

Benefits of telemedicine have been proven in the field of diabetes. Among a number of technical solutions, Diabeo® has been studied in both type 1 and type 2 diabetes with intensive insulin therapy. This digital therapeutic system contains a self-monitoring glucose logbook and offers automated insulin dose recommendations thanks to a fully customizable algorithm. Read More

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http://dx.doi.org/10.1177/1932296819834054DOI Listing
March 2019
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Methylphenidate effects on processing speed in a clinical sample of adults with ADHD and substance use disorder: a pilot study.

Nord J Psychiatry 2019 Mar 12:1-7. Epub 2019 Mar 12.

d Department of Psychiatry , Västervik Sjukhus , Västervik , Sweden.

Background: Substance use disorders (SUDs) are common comorbidities of Attention Deficit Hyperactivity Disorder (ADHD). The most commonly prescribed medication for ADHD is methylphenidate. The clinical response to methylphenidate may be monitored against DSM-5 symptomatology, rating scales or interviews. Read More

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http://dx.doi.org/10.1080/08039488.2019.1573922DOI Listing
March 2019
1 Read

12 Impact of Aripiprazole Long-acting Injectable (ALAI) Initiation on Hospitalizations and Visits to Emergency.

CNS Spectr 2019 Feb;24(1):179-180

3La Fe University and Polythecnic Hospital,Valencia,Spain.

Background: Aripiprazole once-monthly is an LAI formulation of aripiprazole that is currently approved in the USA and Europe for the treatment of schizophrenia. Some studies have reported a decline in hospital admissions and emergency use after initiation on long-acting injectable (LAI) antipsychotics, but the effects of using recently commercialised LAI aripiprazole remains uncertain.AimsTo characterize the impact of ALAI initiation on number of hospitalizations and visits to the emergency service, among patients suffering from schizophrenia attending regularly to psychiatric consultations of Gregorio Marañón University General Hospital (Madrid, Spain). Read More

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http://dx.doi.org/10.1017/S1092852919000087DOI Listing
February 2019
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Association of growth differentiation factor 15 with other key biomarkers, functional parameters and mortality in community-dwelling older adults.

Age Ageing 2019 Mar 11. Epub 2019 Mar 11.

Institute of Epidemiology and Medical Biometry, Ulm University, D-89081 Ulm, Germany.

Background: Growth differentiation factor 15 (GDF-15) has been associated with many adverse age-related outcomes and other age-related disorders. The aim of the study was to investigate if baseline levels of GDF-15 are associated with total mortality in community living, older adults during eight years of follow-up after simultaneous consideration of key biomarkers and functional parameters.

Methods: prospective cohort study including 1,470 community-dwelling older adults aged 65 years or older. Read More

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http://dx.doi.org/10.1093/ageing/afz022DOI Listing
March 2019
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Insulin resistance and obesity, and their association with depression in relatively young people: findings from a large UK birth cohort.

Psychol Med 2019 Mar 11:1-10. Epub 2019 Mar 11.

Institute for Mental Health, University of Birmingham,Birmingham,England.

Background: Depression frequently co-occurs with disorders of glucose and insulin homeostasis (DGIH) and obesity. Low-grade systemic inflammation and lifestyle factors in childhood may predispose to DGIH, obesity and depression. We aim to investigate the cross-sectional and longitudinal associations among DGIH, obesity and depression, and to examine the effect of demographics, lifestyle factors and antecedent low-grade inflammation on such associations in young people. Read More

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http://dx.doi.org/10.1017/S0033291719000308DOI Listing
March 2019
1 Read

Social functioning outcomes among individuals with substance use disorders receiving internet-delivered community reinforcement approach.

Subst Use Misuse 2019 Mar 8:1-8. Epub 2019 Mar 8.

a Columbia University Medical Center, Department of Psychiatry , New York State Psychiatric Institute , New York , New York , USA.

Background: The community reinforcement approach (CRA) is an evidence-based practice for the treatment of substance use disorders and achieving and maintaining abstinence, but few studies have systematically explored the effect of CRA on secondary, yet also important outcomes, such as social functioning.

Objectives: The purpose of this study was to examine whether an internet-based version of the CRA plus contingency management is associated with improved social functioning of individuals seeking substance use disorder treatment in a multi-site clinical effectiveness trial.

Methods: Social functioning was measured using the 54-item Social Adjustment Scale assessing role performance in six domains (work, social and leisure activities, extended family relationships, marital relationship, parenting, and immediate family). Read More

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http://dx.doi.org/10.1080/10826084.2018.1528458DOI Listing
March 2019
1 Read

Prevalence and relationship of hypertriglyceridaemic-waist phenotype and type 2 diabetes mellitus among a rural adult Chinese population.

Public Health Nutr 2019 Mar 8:1-6. Epub 2019 Mar 8.

1Department of Preventive Medicine,Shenzhen University Health Sciences Center,3688 Nanhai Avenue,Nanshan District,Shenzhen,Guangdong 518060,People's Republic of China.

Objective: Limited information is available on the prevalence and effect of hypertriglyceridaemic-waist (HTGW) phenotype on the risk of type 2 diabetes mellitus (T2DM) in rural populations.

Design: In the present cross-sectional study, we investigated the prevalence of the HTGW phenotype and T2DM and the strength of their association among rural adults in China.

Setting: HTGW was defined as TAG >1·7 mmol/l and waist circumference (WC) ≥90 cm for males and ≥80 cm for females. Read More

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http://dx.doi.org/10.1017/S1368980019000181DOI Listing
March 2019
1 Read
2.679 Impact Factor

Cariprazine Treatment of Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Phase 3 Study.

Am J Psychiatry 2019 Mar 8:appiajp201818070824. Epub 2019 Mar 8.

Allergan, Madison, N.J. (Earley, Burgess, Rekeda, Dickinson); Gedeon Richter, Budapest, Hungary (Szatmári, Németh); the Mood Disorders Psychopharmacology Unit, University Health Network, Toronto (McIntyre); the Department of Psychiatry, Harvard Medical School, and the Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston (Sachs); and the Department of Psychiatry, University of British Columbia, Vancouver (Yatham).

Objective:: Cariprazine, a dopamine D/D and 5-HT receptor partial agonist, was found to be effective in treating bipolar I depression in a previous phase 2 study. This phase 3 study further assessed the efficacy, safety, and tolerability of cariprazine in bipolar I depression.

Methods:: In a double-blind placebo-controlled study, adult participants (18-65 years old) who met DSM-5 criteria for bipolar I disorder and a current depressive episode were randomly assigned to receive placebo (N=158) or cariprazine at 1. Read More

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http://dx.doi.org/10.1176/appi.ajp.2018.18070824DOI Listing
March 2019
1 Read
12.295 Impact Factor

Exposure to Negative Life Events and Post-Traumatic Embitterment Symptoms in Young Adults in Korea: Cumulative and Differential Effects.

Psychopathology 2019 Mar 7:1-8. Epub 2019 Mar 7.

Background: Post-traumatic embitterment disorder (PTED) has recently been introduced as a subgroup of adjustment disorders related to stressful life events. Embitterment is defined as persistent feelings of inadequacy or hoping for revenge after being insulted but feeling helpless after experiencing a life stressor. This study aims to investigate the cumulative and differential effects of negative life events on the risk of developing embitterment among young adults in South Korea. Read More

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http://dx.doi.org/10.1159/000496501DOI Listing
March 2019
1 Read

Exposure to Second-Generation Antipsychotics and Risk of Type 2 Diabetes Mellitus in Adolescents and Young Adults: A Nationwide Study in Taiwan.

J Clin Psychiatry 2019 Mar 5;80(2). Epub 2019 Mar 5.

Department of Psychiatry, No. 201, Shih-Pai Rd, Sec. 2, 11217, Taipei, Taiwan.

Background: The association between second-generation antipsychotics (SGAs) and type 2 diabetes mellitus (T2DM) has been well investigated in adults. However, T2DM risk has been less examined among adolescents with SGA exposure, and the risk remains uncertain in this population.

Methods: A total of 91,185 adolescents and young adults within the Taiwan National Health Insurance system who were exposed to SGAs were enrolled into this study between 2000 and 2011. Read More

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http://dx.doi.org/10.4088/JCP.18m12284DOI Listing
March 2019
1 Read
5.498 Impact Factor

One's Workplace, Other's Home? Work and Health of Domestic Workers in Argentina.

Ann Glob Health 2018 Aug 31;84(3):450-458. Epub 2018 Aug 31.

MunBaus, Av. Mariano Acosta 1254, (1407), Buenos Aires, AR.

Background: Domestic workers around the world work and eventually live in private homes where control of working conditions is difficult.

Objective: The aim of this study was to compare working conditions and its impact on general and mental health in live-in and live-out domestic workers in Argentina.

Methods: In a cross-sectional study, the Spanish version of the European Workings Condition Survey and an ad hoc questionnaire were applied to 201 domestic workers (response 94%). Read More

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http://dx.doi.org/10.29024/aogh.2311DOI Listing
August 2018
1 Read

Comparison of exhaustion symptoms in patients with stress-related and other psychiatric and somatic diagnoses.

BMC Psychiatry 2019 Mar 4;19(1):84. Epub 2019 Mar 4.

National Research Centre for the Working Environment, Copenhagen, Denmark.

Background: Several rating scales assessing stress-related symptoms of exhaustion have emerged in recent years. However, more knowledge is needed about the performance of these rating scales in patients with stress-related disorders as well as in other patient groups. With the recently developed Karolinska Exhaustion Disorder Scale (KEDS), we compared symptoms of exhaustion in different patient groups that were sorted according to diagnosis. Read More

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http://dx.doi.org/10.1186/s12888-019-2066-yDOI Listing
March 2019
1 Read

Lack of Association Between Select Circulating miRNAs and Bone Mass, Turnover, and Fractures: Data From the OFELY Cohort.

J Bone Miner Res 2019 Mar 4. Epub 2019 Mar 4.

INSERM UMR 1033, Université de Lyon, Lyon, France.

Postmenopausal osteoporosis is characterized by the occurrence of fragility fracture with an increase in morbidity and mortality. Recently, microRNAs (miRNAs) have raised interest as regulators of translational repression, mediating a number of key processes, including bone tissue in both physiological and diseased states. The aim of this study was to examine the serum levels of 32 preselected miRNAs with reported function in bone and their association with osteoporotic fracture. Read More

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http://dx.doi.org/10.1002/jbmr.3685DOI Listing
March 2019
1 Read

Optimizing the clinical utility of four proposed criteria for a persistent and impairing grief disorder by emphasizing core, rather than associated symptoms.

Psychol Med 2019 Mar 4:1-8. Epub 2019 Mar 4.

Center for the Study of Traumatic Stress,Uniformed Services University of the Health Sciences,Bethesda MD 20814,USA.

Background: Distinguishing a disorder of persistent and impairing grief from normative grief allows clinicians to identify this often undetected and disabling condition. As four diagnostic criteria sets for a grief disorder have been proposed, their similarities and differences need to be elucidated.

Methods: Participants were family members bereaved by US military service death (N = 1732). Read More

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http://dx.doi.org/10.1017/S0033291719000254DOI Listing
March 2019
3 Reads

Access to Psychiatrist Services for Older Adults in Long-Term Care: A Population-Based Study.

J Am Med Dir Assoc 2019 Feb 28. Epub 2019 Feb 28.

Department of Psychiatry, Queen's University, Kingston, ON, Canada; ICES Queen's University, Kingston, ON, Canada. Electronic address:

Objectives: Although mental health disorders are common among older adults in long-term care (LTC), little is known about access to psychiatric services in LTC. We described the need for psychiatric services in LTC settings and identified variables associated with receipt of psychiatric services.

Design: Population-based retrospective cohort study. Read More

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http://dx.doi.org/10.1016/j.jamda.2019.01.121DOI Listing
February 2019
1 Read

Relationship between serum uric acid and clustering of cardiovascular disease risk factors and renal disorders among Shanghai population: a multicentre and cross-sectional study.

BMJ Open 2019 Mar 1;9(3):e025453. Epub 2019 Mar 1.

Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Objectives: To estimate the current prevalence of cardiovascular disease risk factors (CRFs) and renal disorders across serum uric acid (SUA) quartiles, and evaluate the relationships between SUA and CRFs and renal diseases in Shanghai population.

Study Design: Observational, cross-sectional study.

Setting: Data were obtained from the physical check-up of local residents at three hospitals in Shanghai. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025453DOI Listing
March 2019
1 Read

Epigenetic marks of prenatal air pollution exposure found in multiple tissues relevant for child health.

Environ Int 2019 Feb 28;126:363-376. Epub 2019 Feb 28.

Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Background: Prenatal air pollution exposure has been linked to many adverse health conditions in the offspring. However, little is known about the mechanisms underlying these associations. Epigenetics may be one plausible biologic link. Read More

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http://dx.doi.org/10.1016/j.envint.2019.02.028DOI Listing
February 2019
1 Read

Role of vitamin D and vitamin D receptor gene polymorphisms on residual beta cell function in children with type 1 diabetes mellitus.

Pharmacol Rep 2018 Dec 28;71(2):282-288. Epub 2018 Dec 28.

Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: After the onset of type 1 diabetes mellitus (T1DM), preservation of the residual ß-cell function can help good metabolic control. The aim of this study was to evaluate the effect of vitamin D and its receptor gene polymorphisms on residual ß-cells function.

Methods: One hundred and one children with T1DM (new cases) older than 5 years were selected. Read More

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http://dx.doi.org/10.1016/j.pharep.2018.12.012DOI Listing
December 2018
2 Reads

Longitudinal trajectory of early functional recovery in patients with first episode psychosis.

Schizophr Res 2019 Feb 27. Epub 2019 Feb 27.

Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA; Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, HMS, Boston, MA, USA.

Background: There is a large variability in the recovery trajectory and outcome of first episode of psychosis [FEP] patients. To date, individuals' outcome trajectories at early stage of illness and potential risk factors associated with a poor outcome trajectory are largely unknown. This study aims to apply three separate predictors (positive symptoms, negative symptoms, and soft neurological signs) to identify homogeneous function outcome trajectories in patients with FEP using objective data-driven methods, and to explore the potential risk /protective factors associated with each trajectory. Read More

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http://dx.doi.org/10.1016/j.schres.2019.02.003DOI Listing
February 2019
1 Read

Pre-pregnancy kidney function and subsequent adverse pregnancy outcomes.

Pregnancy Hypertens 2019 Jan 1;15:195-200. Epub 2019 Feb 1.

Cardiovascular and Metabolism Section, Division of Research, Kaiser Permanente Northern California, Oakland, CA, United States. Electronic address:

Background: Renal insufficiency is associated with pregnancy complications including fetal growth restriction, preterm birth (PTB), and pre-eclampsia.

Objective: To determine the effect of preconception kidney function within the normal range on pregnancy outcome.

Method: 1043 (50% black, 50% white) women who participated in the CARDIA study who had kidney function and biochemical analyses measured before at least one pregnancy delivered during the 20 years post-baseline period were included in analysis. Read More

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http://dx.doi.org/10.1016/j.preghy.2019.01.011DOI Listing
January 2019
1 Read

Risk of hypertension and abnormal biomarkers in the first year postpartum associated with hypertensive disorders of pregnancy among overweight and obese women.

Pregnancy Hypertens 2019 Jan 2;15:1-6. Epub 2018 Nov 2.

Department of Obstetrics, Gynecology and Reproductive Sciences, Univeristy of Pittsburgh School of Medicine, United States; Magee-Womens Research Institute, University of Pittsburgh, United States; Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, United States.

Objectives: Hypertension and obesity are common cardiometabolic risk factors in reproductive age women. The association of hypertensive disorders of pregnancy with later-life cardiovascular disease is well-established, however, it is unknown how obesity and hypertensive disorders of pregnancy converge to accelerate development of hypertension in the postpartum period. The aim of this study was to characterize rates of sustained hypertension at one year postpartum using the new American Heart Association/American College of Cardiology Guidelines among overweight and obese women with a normotensive pregnancy or hypertensive disorder of pregnancy. Read More

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http://dx.doi.org/10.1016/j.preghy.2018.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400304PMC
January 2019
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Association of opium addiction with rupture of intracranial aneurysms: A case-control study.

World Neurosurg 2019 Feb 27. Epub 2019 Feb 27.

Department of Neurosurgery, Ghaem Teaching and Referral Hospital, Ahmad Abad Blvd, Parastar street, Mashhad, Razavi-khorasan province, Iran.

Background: Disorders related to opioid use account for the most substantial burden of disease attributable to drug use disorders. We aimed to justify if there is an association between either opium consumption or addiction and rupture of intracranial aneurysms.

Methods: In this case-control study, we enrolled 50 cases with ruptured intracranial aneurysms and 43 control subjects with an incidental finding of an intracranial aneurysm without a history of SAH. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.077DOI Listing
February 2019

Low-dose rt-PA may not decrease the incidence of symptomatic intracranial haemorrhage in patients with high risk of symptomatic intracranial haemorrhage.

Neurol Res 2019 Mar 1:1-7. Epub 2019 Mar 1.

a Center of Stroke , Beijing Tiantan Hospital, Capital Medical University , Beijing , China.

Background: Recombinant tissue plasminogen activator (rt-PA) has been used as the standard treatment for acute ischemic stroke (AIS). The following study investigates whether low-dose rt-PA can decrease the incidence of symptomatic intracranial haemorrhage (sICH) in AIS patients with high-risk sICH compared to standard-dose rt-PA.

Materials And Methods: Data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China) studies were assessed to explore risk factors for sICH after intravenous thrombolysis. Read More

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http://dx.doi.org/10.1080/01616412.2019.1580454DOI Listing
March 2019
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1.449 Impact Factor

Behavioral health conditions and potentially preventable diabetes-related hospitalizations in the United States: Findings from a national sample of commercial claims data.

PLoS One 2019 28;14(2):e0212955. Epub 2019 Feb 28.

Magellan Rx, Magellan Inc., Scottsdale, Arizona, United States of America.

Objective: To characterize the relationship between potentially preventable hospitalizations (PPHs) for diabetes and behavioral health conditions in commercially insured working-age persons with diabetes in the United States.

Research Design And Methods: We retrospectively analyzed medical and pharmacy claims from services rendered between 2011 and 2013 for 229,039 adults with diabetes. Diabetes PPHs were identified using the Agency for Healthcare Research and Quality's Prevention Quality Indicators v6. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212955PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394977PMC
February 2019
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Cross-sectional study of neutrophil-lymphocyte, platelet-lymphocyte and monocyte-lymphocyte ratios in mood disorders.

Gen Hosp Psychiatry 2019 Feb 15;58:7-12. Epub 2019 Feb 15.

Department of Medicine and Surgery, University of Milano Bicocca, Monza, MB, Italy.

Objective: Neutrophil-lymphocyte, monocyte-lymphocyte and platelet-lymphocyte ratio are inexpensive and reproducible biomarkers of inflammation found to be elevated in mood disorders. This study aimed to compare inflammatory ratios between bipolar disorder and major depressive disorder and between bipolar disorder manic episodes and bipolar disorder depressive episodes.

Method: We included 142 Caucasian patients (major depressive disorder: n = 36; bipolar disorder manic episode: n = 66; bipolar disorder depressive episode: n = 40). Read More

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http://dx.doi.org/10.1016/j.genhosppsych.2019.02.003DOI Listing
February 2019
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Impact of chemotherapy on the association between fear of cancer recurrence and the gut microbiota in breast cancer survivors.

Brain Behav Immun 2019 Feb 25. Epub 2019 Feb 25.

Division of Health Care Research, Center for Public Health Sciences, National Cancer Center Japan, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Electronic address:

Background: Dysfunctional processing of fear memory may be involved in the pathophysiology of fear of cancer recurrence (FCR), which is cited as the major unmet psychological need of cancer survivors. Emerging evidence has shown that the microbiota-gut-brain (MGB) axis affects depressive and anxiety disorders, and chemotherapy-associated psychological distress. We therefore hypothesized that the gut microbiota is associated with FCR in cancer survivors. Read More

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http://dx.doi.org/10.1016/j.bbi.2019.02.025DOI Listing
February 2019
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Strategies for individualized dosing of clotting factor concentrates and desmopressin in hemophilia A and B.

Ther Drug Monit 2019 Feb 26. Epub 2019 Feb 26.

Hospital Pharmacy-Clinical Pharmacology, Amsterdam UMC, University of Amsterdam, the Netherlands.

Hemophilia A and B are hereditary bleeding disorders, caused by a deficiency of clotting factor VIII or clotting factor IX, respectively. To treat and prevent bleedings, patients can administer clotting factor concentrates (hemophilia A and B) or desmopressin (hemophilia A). Both clotting factor concentrates and desmopressin are currently dosed according to the patients' body weight. Read More

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http://dx.doi.org/10.1097/FTD.0000000000000625DOI Listing
February 2019
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Δ4-3-oxosteroid-5β-reductase deficiency: Responses to oral bile acid therapy and long-term outcomes.

World J Gastroenterol 2019 Feb;25(7):859-869

The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai 201102, China.

Background: Disorders of primary bile acid synthesis may be life-threatening if undiagnosed, or not treated with primary bile acid replacement therapy. To date, there are few reports on the management and follow-up of patients with Δ4-3-oxosteroid 5β-reductase (AKR1D1) deficiency. We hypothesized that a retrospective analysis of the responses to oral bile acid replacement therapy with chenodeoxycholic acid (CDCA) in patients with this bile acid synthesis disorder will increase our understanding of the disease progression and permit evaluation of this treatment regimen as an alternative to the Food and Drug Administration (FDA) approved drug cholic acid, which is currently unavailable in China. Read More

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http://dx.doi.org/10.3748/wjg.v25.i7.859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385010PMC
February 2019
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Risk of severe maternal morbidity associated with in vitro fertilization: a population-based study.

BJOG 2019 Feb 24. Epub 2019 Feb 24.

Inserm UMR 1153 Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Centre for Epidemiology and Statistics Sorbonne Paris Cité, DHU Risks in Pregnancy, Paris Descartes University, Paris, France.

Objective: To investigate the association between IVF and severe maternal morbidity (SMM) and to explore the role of multiple pregnancy as an intermediate factor.

Design: Population-based cohort-nested case-control study.

Setting: 6 French regions in 2012-2013. Read More

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http://dx.doi.org/10.1111/1471-0528.15668DOI Listing
February 2019
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Prolonged grief disorder: Its co-occurrence with adjustment disorder and post-traumatic stress disorder in a bereaved Israeli general-population sample.

J Affect Disord 2019 Apr 6;249:307-314. Epub 2019 Feb 6.

University of Zürich, Department of Psychology, Division Psychopathology and Clinical Intervention, CH-8050 Zürich, Switzerland.

Background: Prolonged grief disorder (PGD) is a new disorder included in the WHO International Classification of Diseases 11th version (ICD-11). This study is the first to use these new ICD-11 PGD guidelines to examine prevalence rates, predictors of PGD and disorder co-occurrence with other stress-related disorders in a survey of 544 bereaved Israelis.

Methods: Descriptive statistics, correlation, linear regression and mediation analysis examined the validity of the ICD-11 diagnostic algorithm. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.014DOI Listing
April 2019
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Three-dimensional drivable optrode array for high-resolution neural stimulations and recordings in multiple brain regions.

Biosens Bioelectron 2019 Apr 5;131:9-16. Epub 2019 Feb 5.

National Key Laboratory of Science and Technology on Micro/Nano Fabrication Laboratory, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Collaborative Innovation Center of IFSA, Department of Micro/Nano-electronics, Shanghai Jiao Tong University, Shanghai 200240, PR China. Electronic address:

The brain-computer interface (BCI) devices are of prime important for study of nervous system as well as diagnosis and treatment of neurological disorders. To meet the needs of the BCI devices in high-density integration and multi-functionalization, 3-dimensional (3D) drivable optrode array with laser diodes (LDs) coupled waveguides was developed. The unique device realizes the 3D integration of the optrodes and avoids fiber tangle and tissue heating by adopting LD coupled waveguide structure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193004
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http://dx.doi.org/10.1016/j.bios.2019.01.019DOI Listing
April 2019
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Somatization and Coping in Ethnic Minority Recruits.

Mil Med 2019 Feb 22. Epub 2019 Feb 22.

University of Basel, Psychiatric Clinics (UPK), Center for Affective, Stress and Sleep Disorders (ZASS), Wilhelm Klein-Strasse 27, Basel, Switzerland.

Introduction: Military service can have beneficial social effects on minorities. However, minority groups are also often at greater risk of somatizing psychological distress and coping maladaptively. In military training this would result in lower mental health of minorities and contribute to higher drop-out rates. Read More

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http://dx.doi.org/10.1093/milmed/usz014DOI Listing
February 2019
2 Reads