5,411 results match your criteria Adjuncts to the Forensic Autopsy


Foam Sclerotherapy Augmented Phlebectomy (SAP) Procedure for Varicose Veins: Report of a Novel Technique.

EJVES Short Rep 2018 16;41:16-18. Epub 2018 Nov 16.

Cambridge University Hospitals and Imperial College, London, UK.

Introduction: While traditional ambulatory phlebectomy (AP) is a safe and effective procedure, few adverse effects such as hematoma, bleeding, bruising and nerve injury have been reported. To improve AP and to reduce some of these adverse events, herein we report a novel technique - Foam Sclerotherapy Assisted Phlebectomy (SAP).

Report: The details of the above technique, along with the potential advantages and limitations will be discussed. Read More

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November 2018
4 Reads

The impact of 5-aminolevulinic acid on extent of resection in newly diagnosed high grade gliomas: a systematic review and single institutional experience.

J Neurooncol 2018 Dec 1. Epub 2018 Dec 1.

Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Health System, Detroit, MI, USA.

Background: Glioma surgery at its nascency relied predominantly on visual and tactile feedback for the removal of grossly abnormal tissue. This technique has inherent limitations in delineating infiltrative tumor from normal brain, thus limiting the ability to achieve a gross total resection consistently. Since extent of resection (EOR) is consistently correlated with measures of survival, fluorescence-guided surgery shows promise in improving our ability to treat high-grade gliomas (HGG). Read More

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December 2018

Minimally Invasive Treatment for Benign Prostatic Hyperplasia: Economic Evaluation from a Standardized Hospital Case Costing System.

Cardiovasc Intervent Radiol 2018 Nov 30. Epub 2018 Nov 30.

Division of Vascular and Interventional Radiology, Department of Medical Imaging, Toronto General Hospital, University Health Network, University of Toronto, 585 University Ave, Toronto, ON, M5G 2N2, Canada.

Purpose: Minimally invasive alternatives to transurethral resection of the prostate (TURP) such as prostate arterial embolization (PAE) and photoselective vaporization of the prostate (PVP) are being explored as adjuncts in the care of patients with benign prostatic hyperplasia. However, there are conflicting reports of the costs of these procedures. The purpose of this study was to compare the direct and indirect hospital costs of TURP, PAE and PVP. Read More

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November 2018
1 Read

Brewing with malted barley or raw barley: what makes the difference in the processes?

Appl Microbiol Biotechnol 2018 Dec 4. Epub 2018 Dec 4.

Bioprocessing Technology Institute, Agency for Science, Technology and Research, 20 Biopolis Way, #06-01 Centros, Singapore, 138668, Singapore.

Malted barley is the main source for fermentable sugars used by yeasts in the traditional brewing of beers but its use has been increasingly substituted by unmalted barley and other raw grain adjuncts in recent years. The incorporation of raw grains is mainly economically driven, with the added advantage of improved sustainability, by reducing reliance on the malting process and its associated cost. The use of raw grains however, especially in high proportion, requires modifications to the brewing process to accommodate the lack of malt enzymes and the differences in structural and chemical composition between malted and raw grains. Read More

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December 2018

Prenatal cell-free DNA screening test failures: a systematic review of failure rates, risks of Down syndrome, and impact of repeat testing.

Genet Med 2018 Nov 26;20(11):1312-1323. Epub 2018 Apr 26.

Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Providence, Rhode Island, USA.

Purpose: We systematically reviewed the published literature on test failure rates for the sequencing of cell-free DNA (cfDNA) in maternal plasma to identify Down syndrome.

Methods: We searched peer-reviewed English publications with diagnostic results on all pregnancies that provided test failure rates. Data on the odds of failure in Down syndrome and euploid pregnancies and the impact of repeat testing were extracted. Read More

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November 2018

Social media use in adolescents and young adults with serious illnesses: an integrative review.

BMJ Support Palliat Care 2018 Dec 4. Epub 2018 Dec 4.

School of Healthcare, University of Leeds, Leeds, UK.

Objectives: Adolescents and young adults with life-limiting or life-threatening conditions are often socially isolated because of the demands of their illness. Although adolescents and young adults have a noticeable online and social media presence, their motivations for using social media remain unclear. This article aims to summarise empirical research undertaken about how and why social media is used by adolescents and young adults with life-limiting or life-threatening conditions. Read More

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December 2018
1 Read

Prehospital Airway Management in Iraq and Afghanistan: A Descriptive Analysis.

South Med J 2018 Dec;111(12):707-713

From the US Army Institute of Surgical Research, Joint Base San Antonio-Fort Sam Houston, Texas, the 59th Medical Wing, Joint Base San Antonio-Lackland Air Force Base, Texas, the San Antonio Military Medical Center, Joint Base San Antonio-Fort Sam Houston, Texas, the Madigan Army Medical Center, Joint Base Lewis McChord, Washington, and the Army Medical Department Center and School Health Readiness Center of Excellence, Joint Base San Antonio-Fort Sam Houston, Texas.

Objectives: Airway failures are the second leading cause of potentially preventable death on the battlefield. Improvements in airway management depend on identifying current challenges. We sought to build on previously reported data on prehospital, combat airway management. Read More

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December 2018
2 Reads

Systematic review of cure and recurrence rates following minimally invasive parathyroidectomy.

BJS Open 2018 Dec 28;2(6):364-370. Epub 2018 May 28.

Department of Ear, Nose and Throat, Head and Neck Surgery St George's Hospital London UK.

Background: The majority of patients with primary hyperparathyroidism (PHPT) have a single overactive adenoma. Advances in preoperative imaging and surgical adjuncts have given rise to minimally invasive parathyroidectomy (MIP), with lower complication rates in comparison with bilateral neck exploration. Misdiagnosis and undertreatment of multiglandular disease, leading to potentially higher recurrence rates, remains a concern. Read More

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December 2018
1 Read

Modern Primary Breast Augmentation: Best Recommendations for Best Results.

Plast Reconstr Surg 2018 Dec;142(6):933e-946e

Dallas, Texas From the Dallas Plastic Surgery Institute.

Learning Objectives: After reading this article, the participant should be able to: 1. Develop a practical method for preoperative implant size selection. 2. Read More

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December 2018
1 Read

Pediatric Trainees Managing a Difficult Airway: Comparison of Laryngeal Mask Airway, Direct, and Video-Assisted Laryngoscopy.

OTO Open 2017 Apr-Jun;1(2):2473974X17707916. Epub 2017 May 8.

Department of Otolaryngology-Head and Neck Surgery, Naval Medical Center San Diego, San Diego, California, USA.

Objective: Difficult airway management is a key skill required by all pediatric physicians, yet training on multiple modalities is lacking. The objective of this study was to compare the rate of, and time to, successful advanced infant airway placement with direct laryngoscopy, video-assisted laryngoscopy, and laryngeal mask airway (LMA) in a difficult airway simulator. This study is the first to compare the success with 3 methods for difficult airway management among pediatric trainees. Read More

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The evidence behind the use of platelet-rich plasma (PRP) in scar management: a literature review.

Scars Burn Heal 2018 Jan-Dec;4:2059513118808773. Epub 2018 Nov 18.

Centre for Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK.

Introduction: Autologous platelet-based concentrates represent increasingly popular adjuncts to a variety of medical, surgical and aesthetic interventions. Their beneficial potential rests on the ability to deliver a high concentration of growth factors to the target tissues. There are currently no reports in the literature appraising the evidence behind the use of platelet-rich plasma (PRP) in scar management. Read More

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November 2018

Surgical Adjuncts to Increase the Extent of Resection: Intraoperative MRI, Fluorescence, and Raman Histology.

Neurosurg Clin N Am 2019 Jan;30(1):65-74

Department of Neurosurgery, University Hospital of Münster, Albert-Schweitzer-Campus 1, Geb. A1, Münster 48149, Germany. Electronic address:

In low-grade glioma surgery, depicting tumor margins is challenging. 7 - Bowden 2018 - Sodium Fluorescein Facilitates Guided Sampling of Diagnostic Tumor Tissue.pdf Several tools have emerged to assist surgical decision-making. Read More

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January 2019
4 Reads

Management of acute Achilles tendon ruptures: A review.

Bone Joint Res 2018 Oct 3;7(10):561-569. Epub 2018 Nov 3.

Department of Orthopedic Surgery, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing Key Lab of Regenerative Medicine in Orthopedics, Chinese PLA General Hospital, Beijing, China.

Objectives: The incidence of acute Achilles tendon rupture appears to be increasing. The aim of this study was to summarize various therapies for acute Achilles tendon rupture and discuss their relative merits.

Methods: A PubMed search about the management of acute Achilles tendon rupture was performed. Read More

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October 2018
5 Reads

Technical Considerations for Nephron-Sparing Surgery in Children: What Is Needed to Preserve Renal Units?

J Surg Res 2018 Dec 9;232:614-620. Epub 2018 Aug 9.

Division of Pediatric Surgery, Department of Surgery, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, Michigan.

Background: Chemotherapy is used preoperatively for children with bilateral Wilms tumor (BWT) or unilateral high-risk Wilms tumor (UHRWT) to promote tumor regression to facilitate renal preservation with nephron-sparing surgery (NSS). In adults, various surgical techniques have been described to preserve renal tissue. Few studies have examined the use of surgical adjuncts in NSS in children with renal tumors. Read More

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December 2018
2 Reads

Multimodality Techniques in Microsurgical Clipping as the Gold Standard Treatment in the Management of Basilar Tip Aneurysm: A Case Series.

Asian J Neurosurg 2018 Oct-Dec;13(4):1148-1157

Department of Neurosurgery, Fujita Health University, Banbuntane Hotokukai Hospital, Nagoya, Japan.

Introduction: Basilar aneurysms represent 5%-7% of all intracranial aneurysms. The main goal of open surgery is to achieve complete obliteration of the aneurysmal sac using minimal invasive technique while emphasizing on avoidance of complication.

Materials And Methods: We performed a retrospective cohort study of nine cases of unruptured basilar tip aneurysm referred to the Fujita Health University Banbuntane-Hotokukai Hospital, Japan. Read More

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November 2018
1 Read

Is there an association between central venous pressure measurement and ultrasound assessment of the inferior vena cava?

Afr J Emerg Med 2018 Sep 27;8(3):106-109. Epub 2018 Jul 27.

Division of Emergency Medicine, University of Kwazulu Natal, Durban, South Africa.

Introduction: Early assessment of volume status is paramount in critically ill patients. Central venous pressure (CVP) measurement and ultrasound assessment of the inferior vena cava (IVC) are both used for volume assessment in the emergency centre. Recent data is conflicting over whether there is a correlation between CVP and ultrasound assessment of the IVC. Read More

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September 2018

Plasma Fucosylated Glycans and C-Reactive Protein As Biomarkers of HNF1A-MODY in Young Adult-Onset Nonautoimmune Diabetes.

Diabetes Care 2018 Nov 19. Epub 2018 Nov 19.

Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia

Objective: Maturity-onset diabetes of the young (MODY) due to variants in is the commonest type of monogenic diabetes. Frequent misdiagnosis results in missed opportunity to use sulfonylureas as first-line treatment. A nongenetic biomarker could improve selection of subjects for genetic testing and increase diagnosis rates. Read More

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November 2018
2 Reads

Delayed LY333013 (Oral) and LY315920 (Intravenous) Reverse Severe Neurotoxicity and Rescue Juvenile Pigs from Lethal Doses of (Eastern Coral Snake) Venom.

Toxins (Basel) 2018 Nov 17;10(11). Epub 2018 Nov 17.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José 11501-2060, Costa Rica.

Objective: There is a clear, unmet need for effective, lightweight, shelf-stable and economical snakebite envenoming therapies that can be given rapidly after the time of a snake's bite and as adjuncts to antivenom therapies in the hospital setting. The sPLA2 inhibitor, LY315920, and its orally bioavailable prodrug, LY333013, demonstrate surprising efficacy and have the characteristics of an antidote with potential for both field and hospital use.

Methods: The efficacy of the active pharmaceutical ingredient (LY315920) and its prodrug (LY333013) to treat experimental, lethal envenoming by (Eastern coral snake) venom was tested using a porcine model. Read More

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November 2018
1 Read

Systematic Review of the Efficacy and Safety of Gabapentin and Pregabalin for Pain in Children and Adolescents.

Anesth Analg 2018 Nov 16. Epub 2018 Nov 16.

From the Clinical Pharmacology and Toxicology Research Group, Discipline of Pharmacology, University of Sydney, New South Wales, Australia.

The barriers to opioid use in some countries necessitate the need to identify suitable alternatives or adjuncts for pain relief. The gabapentinoids (gabapentin and pregabalin) are approved for the management of persistent pain in adults, but not in children. Searches were conducted in Embase, Medline, Scopus, and Web of Science up until November 2017, for randomized controlled trials that investigated the analgesic effects of gabapentin or pregabalin in children and adolescents <18 years of age. Read More

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November 2018
2 Reads

Innovative surgical guidance for label-free real-time parathyroid identification.

Surgery 2018 Nov 12. Epub 2018 Nov 12.

Vanderbilt Biophotonics Center, Vanderbilt University, Nashville, TN; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN. Electronic address:

Background: Difficulty in identifying the parathyroid gland during neck operations can lead to accidental parathyroid gland excisions and postsurgical hypocalcemia. A clinical prototype called as PTeye was developed to guide parathyroid gland identification using a fiber-optic probe that detects near-infrared autofluorescence from parathyroid glands as operating room lights remain on. An Overlay Tissue Imaging System was designed concurrently to detect near-infrared autofluorescence and project visible light precisely onto parathyroid gland location. Read More

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November 2018
2 Reads

Management of maxillary first molar with six canals using operating microscope.

Indian J Dent Res 2018 Sep-Oct;29(5):683-686

Department of Conservative Dentistry, Kannur Dental College, Anjarakandy, Kannur, Kerala, India.

The purpose of this article was to highlight the importance of having a thorough knowledge about the root canal morphology. This case report highlights the unusual anatomy of a maxillary first molar with three mesiobuccal (MB) canals, two palatal canals, and one distobuccal canal which is extremely rare. The use of operating microscope was crucial, both for the detection and for the management of the additional canals. Read More

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November 2018
1 Read

Respiratory adjuncts to NIV in neuromuscular disease.

Respirology 2018 Nov 8. Epub 2018 Nov 8.

Department of Respiratory and Sleep Medicine, Austin Health, Melbourne, VIC, Australia.

Muscle weakness is an intrinsic feature of neuromuscular diseases (NMD). When the respiratory muscles are involved, the ability to take a deep breath is compromised, leading to reduced lung volumes and a restrictive ventilatory impairment. Inspiratory, expiratory and bulbar muscle weakness can also impair cough, which may impede secretion clearance. Read More

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November 2018
1 Read

Opioid Use in the Postoperative Arena: Global Reduction in Opioids After Surgery Through Enhanced Recovery and Gynecologic Surgery.

Clin Obstet Gynecol 2018 Nov 6. Epub 2018 Nov 6.

Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina.

Enhanced recovery programs aim to reduce surgical stress to improve the patient perioperative experience. Through a combination of multimodal analgesia and maintaining a physiological state, postoperative recovery is improved. Many analgesic adjuncts are available that improve postoperative pain control and limit opioid analgesia requirements. Read More

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November 2018
5 Reads

Impacts on in-event, ambulance and emergency department services from patients presenting from a mass gathering event: A retrospective analysis.

Emerg Med Australas 2018 Nov 8. Epub 2018 Nov 8.

Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia.

Objective: The aim of this study was to describe the in-event, ambulance and ED impacts of patient presentations from an Australian mass gathering event (MGE) including patient demographics, provision of care, length of stay and discharge disposition.

Methods: This research was set at one MGE in Australia. The MGE had one first aid post and one in-event health team staffed by doctors, nurses and paramedics. Read More

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November 2018
2 Reads

Applications of Focused Ultrasound in Cerebrovascular Diseases and Brain Tumors.

Neurotherapeutics 2018 Nov 7. Epub 2018 Nov 7.

Focused Ultrasound Foundation, Charlottesville, Virginia, USA.

Oncology and cerebrovascular disease constitute two of the most common diseases afflicting the central nervous system. Standard of treatment of these pathologies is based on multidisciplinary approaches encompassing combination of interventional procedures such as open and endovascular surgeries, drugs (chemotherapies, anti-coagulants, anti-platelet therapies, thrombolytics), and radiation therapies. In this context, therapeutic ultrasound could represent a novel diagnostic/therapeutic in the armamentarium of the surgeon to treat these diseases. Read More

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November 2018
7 Reads

The Surgical Applications of Biologics in Sports Medicine.

Authors:
F Alan Barber

Sports Med Arthrosc Rev 2018 Dec;26(4):196-199

Plano Orthopedic Sports Medicine Center, Plano, TX.

Over the past 25 years an increased appreciation of the positive impact of biologic interventions has driven significant advances in the surgical treatment of shoulder and knee conditions. These biologic adjuncts to treatment promote improved outcomes and have set the stage and increased research and development in this arena. Read More

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December 2018
3 Reads

Ultrasound simulation utilization among point of care ultrasound users: Results of a survey.

J Clin Ultrasound 2018 Nov;46(9):571-574

Department of Emergency Medicine, University of Southern California, Los Angelos, California.

Purpose: While ultrasound simulation devices have long been available as adjuncts to ultrasound education, it is unclear how they are used. We conducted a survey to determine the current utilization of emergency point-of-care ultrasound simulation and describe the current trends in the use of ultrasound simulation.

Methods: A survey was sent to 1270 members of the American College of Emergency Physicians Ultrasound Section via email. Read More

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November 2018

New Advances in the Care of the Hemorrhaging Patient.

Mo Med 2018 Sep-Oct;115(5):434-437

Tessa N. Woods, DO, PGY-6 Surgical Critical Care Fellow, Keela R. Scott, MS3, and Jacob A. Quick, MD, FACS, are in the Division of Acute Care Surgery, Department of Surgery, University of Missouri School of Medicine, Columbia, Missouri.

Thirty-three percent of early traumatic deaths are secondary to hemorrhage. In addition to timing to source control, the literature has seen a surge of research on adjuncts in hemorrhage control. This review focuses on three of the latest interventions in the management of the bleeding patient; an endovascular aortic occlusive balloon, tranexamic acid (TXA), and updates to the massive transfusion protocol. Read More

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November 2018
1 Read

Pharmacologic Treatment of Opioid Use Disorder: a Review of Pharmacotherapy, Adjuncts, and Toxicity.

J Med Toxicol 2018 Dec 30;14(4):306-322. Epub 2018 Oct 30.

Harvard Medical Toxicology Program, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA.

Opioid use disorder continues to be a significant source of morbidity and mortality in the USA and the world. Pharmacologic treatment with methadone and buprenorphine has been shown to be effective at retaining people in treatment programs, decreasing illicit opioid use, decreasing rates of hepatitis B, and reducing all cause and overdose mortality. Unfortunately, barriers exist in accessing these lifesaving medications: users wishing to start buprenorphine therapy require a waivered provider to prescribe the medication, while some states have no methadone clinics. Read More

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December 2018
5 Reads

Anticonvulsants as monotherapy or adjuncts to treat alcohol withdrawal: A systematic review.

Ann Clin Psychiatry 2018 Nov;30(4):312-325

Chairman, Department of Psychiatry and Behavioral Sciences, Cleveland Clinic Akron General, Akron, Ohio 44307 USA; E-MAIL:

Background: This systematic review evaluates current literature on anticonvulsants to treat alcohol withdrawal symptoms (AWS).

Methods: We performed a literature search of PubMed, MEDLINE, PsycINFO, EMBASE, and Cochrane collaboration databases through September 30, 2016. The search was not restricted by patients' age. Read More

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November 2018
3 Reads

Metabolic Pathways in Kidney Cancer: Current Therapies and Future Directions.

J Clin Oncol 2018 Oct 29:JCO2018792309. Epub 2018 Oct 29.

W. Kimryn Rathmell and Jeffrey C. Rathmell, Vanderbilt-Ingram Cancer Center and Vanderbilt University Medical Center, Nashville, TN; W. Marston Linehan, National Institutes of Health, Bethesda, MD.

Background: Renal cell carcinoma (RCC) has become known as a metabolic disease, owing to the diverse array of metabolic defects and perturbations that occur as a result of the unique genetics that can drive these tumors. Recent attention to this feature of RCCs has fueled interest in targeting metabolism as a therapeutic strategy.

Methods: We conducted a literature search to develop themes around discrete pathways or processes of cellular metabolism, provide a framework for understanding emerging therapeutic strategies, and consider future interventions. Read More

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October 2018
5 Reads

2017 David Sun Lecture: Screening and Surveillance of Barrett's Esophagus: Where Are We Now and What Does the Future Hold?

Authors:
Gary W Falk

Am J Gastroenterol 2018 Oct 25. Epub 2018 Oct 25.

Division of Gastroenterology Department of Medicine Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Barrett's esophagus and esophageal adenocarcinoma continue to present considerable management challenges in the Western world. Despite our best efforts to date, the prognosis of advanced esophageal adenocarcinoma remains poor and far too many individuals with esophageal adenocarcinoma have not had a prior endoscopy to detect Barrett's esophagus. As such, current strategies of screening for Barrett's esophagus and subsequent surveillance need to be further optimized. Read More

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October 2018

A comparison of Malone appendicostomy and cecostomy for antegrade access as adjuncts to a bowel management program for patients with functional constipation or fecal incontinence.

J Pediatr Surg 2018 Oct 5. Epub 2018 Oct 5.

Center for Colorectal and Pelvic Reconstruction, Nationwide Children's Hospital, Columbus, OH.

Background: Appendicostomy and cecostomy are two approaches for antegrade enema access for children with severe constipation or fecal incontinence as adjuncts to a mechanical bowel management program. Each technique is associated with a unique set of complications. The purpose of our study was to report the rates of various complications associated with antegrade enema access techniques to help guide which option a clinician offers to their patients. Read More

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October 2018
7 Reads

Trazodone in Sexual Medicine: Underused and Overdosed?

Authors:
Robert E Pyke

Sex Med Rev 2018 Oct 17. Epub 2018 Oct 17.

Pykonsult, LLC, New Fairfield, CT, USA. Electronic address:

Introduction: Treatment of hypoactive sexual desire disorder (HSDD) remains unfulfilled. The only approved medication, flibanserin (FLI), is highly underused owing to concerns about central nervous system (CNS) depression and interactions. Trazodone (TRZ), which is not often used for sexual problems, has evidence suggesting efficacy but similar concerns. Read More

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October 2018
5 Reads

Measurement of Adjuncts in Hard Ciders Obtainable in the United States Using Carbon Isotopes.

J Agric Food Chem 2018 Oct 19;66(43):11422-11425. Epub 2018 Oct 19.

Department of Earth & Planetary Sciences , University of New Mexico , Albuquerque , New Mexico 87131 , United States.

The carbon isotope compositions (δC values) of 23 hard ciders obtainable in the United States were analyzed to detect adjuncts, specifically added C sugars (i.e., corn syrup and cane sugar). Read More

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October 2018
10 Reads

Understanding the Modern Surgical Journal Club.

J Surg Educ 2018 Oct 13. Epub 2018 Oct 13.

Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Objective: We sought to perform a comprehensive review of how journal club (JC) is utilized in surgical residencies, including the goals, structure and outcomes of the educational activity, and any changes made since the 2003 implementation of the 80-hour weekly resident duty hour limit.

Design: A random, representative cohort of 75 of the 266 US general surgery residency programs was identified, and Program Directors were asked to complete an 18-question electronic survey about to the ways in which their program utilizes JC.

Setting: General surgery residency programs of all types, sizes, and in all geographies. Read More

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October 2018
4 Reads

Adjunct medications for peripheral and neuraxial anesthesia.

Best Pract Res Clin Anaesthesiol 2018 Jun 3;32(2):83-99. Epub 2018 Jul 3.

Department of Anesthesiology, LSU Health Sciences Center, Room 653, 1542 Tulane Ave., New Orleans, LA, 70112, USA. Electronic address:

Regional and neuraxial anesthesia can provide a safer perioperative experience, greater satisfaction, reduced opioid consumption, and reduction of pain, while minimizing side effects. Ultrasound technology has aided clinicians in depositing local anesthetic medication in precise proximity to targeted peripheral nerves. There are a plethora of adjuvants that have been utilized to prolong local anesthetic actions and enhance effects in peripheral nerve blocks. Read More

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June 2018
5 Reads

Metastatic craniocervical hemangiopericytoma presenting with hydrocephalus and papilledema - Case review.

J Clin Neurosci 2018 Oct 30;56:186-187. Epub 2018 Jun 30.

Department of Neurosurgery, Level 1, Old Baker Building, The Alfred Hospital, 55 Commercial Rd, Melbourne, Victoria 3004, Australia. Electronic address:

Hemangiopericytomas are rare mesenchymal tumors with propensity to recur locally and metastasize. We report the unique case of a fifty-five-year-old male with recurrence of a previously resected craniocervical hemangiopericytoma presenting with obstructive hydrocephalus secondary to new metastatic cerebellar deposits. Emergent surgical resection of the cerebellar hemangiopericytomas was performed prior to adjuvant radiotherapy. Read More

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October 2018

Discrimination of Brazilian lager beer by H NMR spectroscopy combined with chemometrics.

Food Chem 2019 Jan 20;272:488-493. Epub 2018 Aug 20.

Institute of Chemistry, São Paulo State University (UNESP), Rua Prof. Francisco Degni 55, Araraquara, Brazil. Electronic address:

H NMR spectroscopy combined with chemometrics was employed to discriminate lager beer samples from two different classes, according to their style and information provided on the label. Partial replacement of barley malt by adjuncts is a common practice adopted by large breweries, which can lead to a decrease in diastatic power, requiring the use of exogenous enzymes. For this reason, small variations in the spectral profile can occur in the carbohydrates region. Read More

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January 2019
2 Reads

Dexamethasone Is Superior to Dexmedetomidine as a Perineural Adjunct for Supraclavicular Brachial Plexus Block: Systematic Review and Indirect Meta-analysis.

Anesth Analg 2018 Oct 9. Epub 2018 Oct 9.

Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada.

Background: Both dexamethasone and dexmedetomidine are effective peripheral nerve block (PNB) perineural adjuncts that prolong block duration. However, each is associated with side effects. With paucity of head-to-head comparisons of these adjuncts, the question of the best adjunct to mix with local anesthetics (LA) for PNB is unanswered. Read More

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October 2018
2 Reads

Secondary antibody deficiency in neurology.

Curr Opin Allergy Clin Immunol 2018 Dec;18(6):481-488

University Hospital of Wales.

Purpose Of Review: Induction of lymphocyte depletion is increasingly used as a therapeutic strategy for central and peripheral neuroinflammatory disease. However, there is also a growing recognition of the treatment-related complication of secondary antibody deficiency (SAD). Although the occurrence of hypogammaglobulinaemia is a recognized phenomenon during immunomodulation, robust data on the coexistence of impaired responses to immunization, and significant and/or atypical infections is scarce. Read More

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December 2018
6 Reads

A clinico-microbiologic study comparing the efficacy of locally delivered chlorhexidine chip and diode LASER as an adjunct to non-surgical periodontal therapy.

J Oral Biol Craniofac Res 2019 Jan-Mar;9(1):67-72. Epub 2018 Sep 5.

Department of Periodontics, Himachal Institutes of Dental Sciences, Paonta Sahib, Himachal Pradesh, India.

Background: Considering the microbial etiology of the periodontal disease, the periodontal therapy aims to control or abolish the pathogenic microbes. The gold standard scaling and root planing procedure has been used since time immemorial but the drawbacks associated with it have led to the development of various adjunctive means. The current study was therefore, performed to comparatively assess the efficacy of local delivery of chlorhexidine and 808-nm diode LASER as an appurtenance to scaling and root planing in patients with chronic periodontitis. Read More

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September 2018
3 Reads

The Role of Liver-Directed Therapy in Metastatic Colorectal Cancer.

Curr Colorectal Cancer Rep 2018 13;14(5):129-137. Epub 2018 Sep 13.

Department of Haematology-Oncology, National University Cancer Institute, Singapore (NCIS), National University Health System, 1E Kent Ridge Road, Singapore, 119228 Singapore.

Purpose Of Review: Colorectal cancer liver metastasis is a major clinical problem, and surgical resection is the only potentially curative treatment. We seek to discuss various liver-directed therapy modalities and explore their roles in the evolving realm of treatment strategies for metastatic colorectal cancer.

Recent Findings: Clinical outcomes for patients with colorectal cancer liver metastases have improved as more patients undergo potentially curative resection and as the armamentarium of systemic treatment and liver-directed therapies continues to expand. Read More

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September 2018
8 Reads

The experiences of women receiving brachytherapy for cervical cancer: A systematic literature review.

Radiography (Lond) 2018 Nov 18;24(4):396-403. Epub 2018 Jul 18.

Faculty of Health and Applied Sciences, Glenside Campus, University of the West of England, Blackberry Hill, Bristol, BS16 1DD, UK. Electronic address:

Objectives: To determine women's experiences of brachytherapy for cervical cancer.

Key Findings: Nineteen studies were included for data extraction/synthesis. Twelve studies focussed on psychological issues, seven on pharmacological aspects of women's experiences. Read More

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November 2018
1 Read

Real-world treatment patterns of PCSK9 inhibitors among patients with dyslipidemia in Germany, Spain, and the United Kingdom.

Curr Med Res Opin 2018 Nov 20:1-7. Epub 2018 Nov 20.

f Amgen (Europe) GmbH , Zug , Switzerland.

Objective: Proprotein convertase subtilisin/kexin type 9 antibody inhibitors (PCSK9i) are approved as adjuncts to maximal tolerated statin therapy to lower low-density lipoprotein cholesterol (LDL-C). This study describes real-world use, characteristics of PCSK9i users and non-users, and factors influencing treatment choice.

Methods: A physician and patient survey was conducted in Germany, Spain, and the UK from December 2016 to April 2017 through the Adelphi Dyslipidemia Disease Specific Program. Read More

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November 2018
3 Reads

Association of water quality with soil-transmitted helminthiasis and diarrhea in Nueva Santa Rosa, Guatemala, 2010.

J Water Health 2018 Oct;16(5):724-736

Division of Foodborne, Waterborne, and Environmental Diseases, CDC, 1600 Clifton Rd, MS A-38, Atlanta, GA 30329, USA.

Improved water quality reduces diarrhea, but the impact of improved water quality on Ascaris and Trichuris, soil-transmitted helminths (STH) conveyed by the fecal-oral route, is less well described. To assess water quality associations with diarrhea and STH, we conducted a cross-sectional survey in households of south-eastern Guatemala. Diarrhea was self-reported in the past week and month. Read More

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October 2018
3 Reads

Assessing the role of virtual reality training in Canadian Otolaryngology-Head & Neck Residency Programs: a national survey of program directors and residents.

J Otolaryngol Head Neck Surg 2018 Oct 1;47(1):61. Epub 2018 Oct 1.

Section of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Calgary, RRDTC - ENT Clinic, 1820 Richmond Rd SW, Calgary, AB, T2T 5C7, Canada.

Background: Given mounting pressure of work hour restrictions, resource constraints, and variability of clinical exposure, Otolaryngology-Head & Neck Surgery (OHNS) residency training has shifted away from the apprenticeship model to embrace the Royal College of Physicians and Surgeons of Canada's "Competence by Design" initiative. As a result, appraising both current and potential educational adjuncts has become increasingly important. In this investigation, a national needs assessment survey was performed to identify strengths, weaknesses, and future opportunities of the current training landscape. Read More

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October 2018
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Adjunctive colposcopy technologies for assessing suspected cervical abnormalities: systematic reviews and economic evaluation.

Health Technol Assess 2018 09;22(54):1-260

Centre for Reviews and Dissemination, University of York, York, UK.

Background: Dynamic Spectral Imaging System (DySIS)map (DySIS Medical Ltd, Edinburgh, UK) and ZedScan (Zilico Limited, Manchester, UK) can be used adjunctively with conventional colposcopy, which may improve the detection of cervical intraepithelial neoplasia (CIN) and cancer.

Objectives: To systematically review the evidence on the diagnostic accuracy, clinical effectiveness and implementation of DySISmap and ZedScan as adjuncts to standard colposcopy, and to develop a cost-effectiveness model.

Methods: Four parallel systematic reviews were performed on diagnostic accuracy, clinical effectiveness issues, implementation and economic analyses. Read More

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September 2018
6 Reads