204 results match your criteria Adiposis Dolorosa

Lurking Under the Surface: Dercum's Disease.

Cureus 2021 Sep 1;13(9):e17649. Epub 2021 Sep 1.

Trauma and Acute Care Surgery, Conemaugh Memorial Medical Center, Johnstown, USA.

Adiposis dolorosa, also known as Dercum's disease, is a rare disorder characterized by debilitating painful lipomas throughout the body. The prevalence and etiology of Dercum's disease are unknown as mentioned in the National Organization of Rare Disorders. We present an interesting case of Dercum's disease in a 53-year-old female who initially presented with a six-week history of painful subcutaneous masses. Read More

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September 2021


U Wollina

Georgian Med News 2021 Jul-Aug(316-317):7-9

Städtisches Klinikum Dresden, Department of Dermatology and Allergology, Germany.

Both lipedema and juxta-articular adiposis dolorsa are painful disorders of subcutaneous adipose tissue. We investigated 297 female patients with lipedema treated at our department for the presence of juxta-articular adiposis dolorsa. Occurrence of both disorders was identified in 4. Read More

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September 2021

Lesion reduction with intralesional deoxycholic acid in Dercum disease with radiographic evidence.

JAAD Case Rep 2021 Sep 26;15:73-75. Epub 2021 Jul 26.

Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts.

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September 2021

Francis Xavier Dercum: Clinician, teacher, scientist.

Clin Dermatol 2021 Mar-Apr;39(2):348-352. Epub 2020 Nov 25.

Department of Dermatology and Cutaneous Biology and Jefferson Center for International Dermatology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:

Francis Xavier Dercum (1856-1931) was a renowned clinician, teacher, and scientist. Although he is widely known as a prominent neurologist and remembered for his treatment of then-President Woodrow Wilson, he also had many contributions to the field of medicine. Specific to dermatology, he provided the first observations and descriptions of adiposis dolorosa, which laid the groundwork for further examination and research. Read More

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November 2020

Metabolic and immunological phenotype of rare lipomatoses: Dercum's disease and Roch-Leri mesosomatic lipomatosis.

Orphanet J Rare Dis 2021 06 29;16(1):290. Epub 2021 Jun 29.

Endocrinology, Diabetology and Metabolism, CHU Lille, 59000, Lille, France.

Context: Dercum's disease (DD) and Roch-Leri mesosomatic lipomatosis (LMS) are rare and poorly characterized diseases. The clinical presentation combines multiple lipomas, painful in DD in contrast with LMS, without lipoatrophy.

Objective: To identify any specific metabolic and immune phenotype of DD and LMS. Read More

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Dercum's Disease: A Case Report of a Patient Having Both Type 1 and Type 2 Dercum's Disease.

Case Rep Dermatol Med 2020 10;2020:6129706. Epub 2020 Nov 10.

University of Alabama, Department of Family Medicine, 801 Campus Drive, Tuscaloosa, AL 35487, USA.

Dercum's disease, or adiposis dolorosa, is a rare disorder which consists of multiple, painful lipomas within the subcutaneous tissue and has a distribution mainly in the abdomen and extremities. Dercum's disease can be defined as in combination with chronic painful adipose tissue. Although the etiology of Dercum's disease is not clear, it is thought to be a combination of a neurological and endocrine disorder. Read More

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November 2020

Minimal incision technique to treat Dercum's disease (adiposis dolorosa).

Dermatol Ther 2020 11 19;33(6):e13751. Epub 2020 Aug 19.

Facultad de Medicina y Hospital Universitario "Dr José Eleuterio González," Servicio de Dermatología, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.

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November 2020

Exophytic Adiposis Dolorosa (Dercum's Disease) of the Thigh: A Case Report.

Cureus 2020 Mar 15;12(3):e7282. Epub 2020 Mar 15.

Plastic Surgery, Reading Hospital, Wyomissing, USA.

Adiposis dolorosa or Dercum's disease is a rare lipomatous disorder characterized by painful lipomas. In this article, we report a case of rather large exophytic adiposis dolorosa causing difficulties with ambulation, and our surgical management of the disorder. To our knowledge, this is the first reported case of a large exophytic adiposis dolorosa of the upper medial thigh causing problems with mobility. Read More

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Angiosarcoma arising in massive localized lymphedema.

Skeletal Radiol 2020 May 16;49(5):815-818. Epub 2020 Jan 16.

University of Missouri, 1 Hospital Dr, Columbia, MO, 65212, USA.

We report a case of a 70-year-old woman with a BMI of 58 who developed cellulitis refractory to treatment, within an area of massive localized lymphedema. Biopsy showed angiosarcoma. MRI showed multiple lobulated, low T1, high T2 masses within a background of prominent soft tissue septal stranding, dilated lymphatic channels, and skin thickening. Read More

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Adiposis Dolorosa Pain Management.

Fed Pract 2019 Nov;36(11):529-533

is a Physiatrist at Kaiser Permanente in Jonesboro, Georgia. is a Physiatrist at CNY Spine and Pain in Syracuse, New York. is the Regional Amputation Center Medical Director at Hunter Holmes Medical Center in Richmond, Virginia. is a Pain Management Physician at Lexington Medical Center in West Columbia, South Carolina. At the time the article was written Young Il Seo was a Fellow in the Department of Physical Medicine and Rehabilitation (PM&R) at Hunter Holmes McGuire VA Medical Center, and Anne Eliason was a Resident in the Department of PM&R at Virginia Commonwealth University in Richmond.

While current approaches to treatment focus on surgery, opiates, and other medications, health care providers may also consider ketamine infusion, electrostimulation, and perineural injections. Read More

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November 2019

Dercum's disease (adiposis dolorosa): a review of clinical presentation and management.

Reumatologia 2019 31;57(5):281-287. Epub 2019 Oct 31.

Department of Internal Medicine, Rheumatology and Clinical Immunology, Medical University of Silesia, Katowice, Poland.

Dercum's disease (adiposis dolorosa) is a rare disease of unknown etiology characterized by painful subcutaneous adipose tissue deposits with various localization over the body. The deposits occur histologically as lipomas and are associated with overweight or obesity and a variety of psychiatric disturbances (anxiety, depression, sleep disturbances). Classification of Dercum's disease is related to size and location of adipose nodules (generalized diffuse, generalized nodular, localized nodular and juxta-articular forms). Read More

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October 2019

Lipedema and Dercum's Disease: A New Application of Bioimpedance.

Lymphat Res Biol 2019 12 13;17(6):671-679. Epub 2019 Aug 13.

TREAT Program, College of Medicine, University of Arizona, Tucson, Arizona.

Lipedema and Dercum's disease (DD) are incompletely characterized adipose tissue diseases, and objective measures of disease profiles are needed to aid in differential diagnosis. We hypothesized that fluid properties, quantified as tissue water bioimpedance in the upper and lower extremities, differ regionally between these conditions. Women (cumulative  = 156) with lipedema ( = 110), DD ( = 25), or without an adipose disease matched for age and body mass index to early stage lipedema patients (i. Read More

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December 2019

[Dercum's disease].

Ugeskr Laeger 2019 May;181(22)

Dercum's disease is a rare disease, which mainly affects women and has an unknown prevalence and aetiology. The disease is characterised by generalised obesity and more than three-month painful subcutaneous adipose tissue not responding to usual pain treatment. A suggested classi-fication of the disease includes four types: generalised diffuse, generalised nodular, localised nodular and juxta-articular. Read More

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Dercum's disease: a rare and underdiagnosed disease.

An Bras Dermatol 2019 Mar-Apr;94(2):251-253. Epub 2019 May 9.

Dermatology Service, Hospital Regional de Presidente Prudente, Universidade do Oeste Paulista, Presidente Prudente (SP), Brazil.

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Novel Use of Deoxycholic Acid for Adiposis Dolorosa (Dercum Disease).

Dermatol Surg 2019 12;45(12):1718-1720

Department of Dermatology, University of Minnesota Medical School, Minneapolis, MN Department of Dermatology, University of Minnesota, Minneapolis, MN.

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December 2019

The red leg dilemma: a scoping review of the challenges of diagnosing lower-limb cellulitis.

Br J Dermatol 2019 05 21;180(5):993-1000. Epub 2018 Dec 21.

Division of Primary Care & National Institute for Health Research, University of Nottingham, Nottingham, U.K.

Background: Presentations of suspected lower-limb cellulitis are commonly misdiagnoses, resulting in avoidable antibiotic prescribing or hospital admissions. Understanding the challenges posed in diagnosing cellulitis may help enhance future care.

Objectives: To examine and map out the challenges and facilitators identified by patients and health professionals in diagnosing lower-limb cellulitis. Read More

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Intravenous Lidocaine for Acute Pain: A Systematic Review.

Pharmacotherapy 2018 12 9;38(12):1250-1259. Epub 2018 Nov 9.

Loyola University Medical Center, Maywood, Illinois.

This systematic review evaluates the safety and efficacy of intravenous (IV) lidocaine for the treatment of acute pain in adult patients. The PubMed database was searched for randomized controlled trials, retrospective cohort studies, case series, and case reports evaluating the use of IV lidocaine for the treatment of acute pain in adult patients, published between January 1970 and January 2018. The primary outcome was pain reduction via the Visual Analog Scale, Verbal Rating Scale, or Numeric Rating Scale among patients treated with IV lidocaine and placebo or active controls. Read More

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December 2018

Subcutaneous adipose tissue therapy reduces fat by dual X-ray absorptiometry scan and improves tissue structure by ultrasound in women with lipoedema and Dercum disease.

Clin Obes 2018 Dec 24;8(6):398-406. Epub 2018 Sep 24.

TREAT Program, College of Medicine, University of Arizona, Tucson, Arizona, USA.

Lipoedema is painful nodular subcutaneous adipose tissue (SAT) on legs and arms of women sparing the trunk. People with Dercum disease (DD) have painful SAT masses. Lipoedema and DD fat resists loss by diet and exercise. Read More

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December 2018

Trauma-induced adiposis dolorosa (Dercum's disease).

BMJ Case Rep 2018 Mar 28;2018. Epub 2018 Mar 28.

Internal Medicine, Reading Hospital and Medical Center, West Reading, Pennsylvania, USA.

We present a case of a 39-year-old man who presented with chronic bilateral upper extremity pain associated with innumerable angiomyolipomas that developed 5 years after a motor vehicle accident involving his upper extremities. Our case notes the rare nature of painful adipose tissue deposits and the diagnostic challenges. Read More

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J Dtsch Dermatol Ges 2018 Mar 12;16(3):313-327. Epub 2018 Feb 12.

Department of Dermatology, Venerology and Allergology, University Medical Center, Göttingen, Germany.

Lipomatoses are benign proliferations of adipose tissue, often with typical distribution patterns, which usually occur without clear causes. In contrast to circumscribed lipomas, they develop diffusely and symmetrically and are not surrounded by a fibrous pseudocapsule. The most common form is benign symmetric lipomatosis (BSL; Launois-Bensaude syndrome), of which four types are distinguished based on the distribution pattern of hyperplastic adipose tissue. Read More

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Low-Dose d-Amphetamine Induced Regression of Liver Fat Deposits in Dercum Disease.

Am J Med 2018 06 31;131(6):705-708. Epub 2018 Jan 31.

Department of Medicine, University of Arizona, Tucson; Department of Medical Imaging, University of Arizona, Tucson. Electronic address:

Background: Dercum disease is a rare disorder of painful subcutaneous adipose tissue masses typically presenting as a constellation of signs and symptoms affecting most organs, including slow lymphatic flow and fatty liver.

Method: The University of Arizona Institutional Review Board considered this report exempt after patient consent. Multislice, multisequence magnetic resonance imaging (MRI) of the abdomen and pelvis was performed prior to and after d-amphetamine, with and without intravenous gadolinium. Read More

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Cutaneous manifestations of obesity and themetabolic syndrome.

Clin Dermatol 2018 Jan - Feb;36(1):81-88. Epub 2017 Sep 8.

Department of Dermatology, Istanbul Medeniyet University School of Medicine, Istanbul, Turkey.

The cutaneous manifestations of obesity and the associated metabolic syndrome (MetS) may present with a wide variety of cutaneous findings, including acanthosis nigricans, acrochordon, cellulitis, psoriasis, hidradenitis suppurativa, acne, and hirsutism. Being aware of such clinical signs and the underlying systemic disorders may facilitate earlier diagnoses, thereby permitting earlier of therapy initiation and prevention of long-term sequelae. In this process, dermatologists are key figures in the early detection of MetS and its clinical manifestations. Read More

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Atypical juxta-articular form of Dercum's disease in a patient treated with tocilizumab for rheumatoid arthritis.

Joint Bone Spine 2018 10 2;85(5):629-630. Epub 2017 Dec 2.

Department of rheumatology, CHU de Caen, 14000 Caen, France; Normandy university, 14032 Caen cedex 5, France; UNICAEN, COMETE, 14032 Caen, France; Inserm, U 1075 COMETE, 14032 Caen, France.

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October 2018

Cutaneous lipomatosis: diagnosing a rare condition.

G Ital Dermatol Venereol 2017 12;152(6):678-680

Department of Dermatology and Venereology, Sapienza University, Umberto I Polyclinic, Rome, Italy.

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December 2017

Widespread painful nodules in a patient with rheumatoid arthritis.

Eur J Intern Med 2017 Dec 3;46:e1-e2. Epub 2017 May 3.

Clinica Medica, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy.

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December 2017

Prominent neurological involvement in Dercum disease.

J Neurol 2017 Apr 13;264(4):796-798. Epub 2017 Feb 13.

Department of Neurology IC, Associazione OASI Maria SS, Troina, Italy.

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Differentiating lipedema and Dercum's disease.

Int J Obes (Lond) 2017 02 18;41(2):240-245. Epub 2016 Nov 18.

Department of Medicine, Medical Imaging and Pharmacy, University of Arizona, Tucson, AZ, USA.

Background: People with lipedema or Dercum's disease (DD) can have a similar distribution of excess painful nodular subcutaneous adipose tissue (SAT), making them difficult to differentiate.

Methods: Case series of 94 patients with DD, 160 with lipedema and 18 with both diagnoses (Lip+DD) from a single clinic in an academic medical center to improve identification and differentiation of these disorders by comparison of clinical findings, prevalence of type 2 diabetes (DM2), hypermobility by the Beighton score and assessment of a marker of inflammation, Total complement activity (CH50).

Results: Differences between groups were by Student's t-test with α of 0. Read More

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February 2017