26,506 results match your criteria Adiposis Dolorosa


Morus alba L. Diminishes visceral adiposity, insulin resistance, behavioral alterations via regulation of gene expression of leptin, resistin and adiponectin in rats fed a high-cholesterol diet.

Physiol Behav 2018 Dec 12. Epub 2018 Dec 12.

Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt. Electronic address:

Ethanolic extract of leaves of Morus alba L. (M. alba), known as white mulberry, was orally administered (100 mg/kg b. Read More

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December 2018

Trimethylamine-N-oxide (TMAO) as Novel Potential Biomarker of Early Predictors of Metabolic Syndrome.

Nutrients 2018 Dec 13;10(12). Epub 2018 Dec 13.

Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.

There is a mechanistic link between the gut-derived metabolite trimethylamine-N-oxide (TMAO) and obesity-related diseases, suggesting that the TMAO pathway may also be linked to the pathogenesis of obesity. The Visceral Adiposity Index (VAI), a gender-specific indicator of adipose dysfunction, and the Fatty Liver Index (FLI), a predictor of non-alcoholic fatty liver disease (NAFLD), are early predictors of metabolic syndrome (MetS). In this cross-sectional observational study, we investigated TMAO levels in adults stratified according to Body Mass Index (BMI) and the association of TMAO with VAI and FLI. Read More

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December 2018

Enhanced hepatic glycogen synthesis and suppressed adenosine deaminase activity by lithium attenuates hepatic triglyceride accumulation in nicotine-exposed rats.

Biomed Pharmacother 2019 Jan 13;109:1417-1427. Epub 2018 Nov 13.

HOPE Cardiometabolic Research Team, Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria. Electronic address:

Reduced liver glycogen synthesis might signify increased glucose flux towards fat synthesis and triggers hepatic triglyceride accumulation and dysmetabolism. Adenosine deaminase (ADA) reduces adenosine content which increases glycogenolysis. In the present study, we evaluate the effect of modulating glycogen synthesis and ADA by lithium chloride (LiCl) on nicotine-induced dysmetabolism. Read More

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January 2019
2.023 Impact Factor

Role of the androgen receptor gene CAG repeat polymorphism on the sequence of pubertal events and adiposity in girls with high dehydroepiandrosterone sulfate.

J Pediatr Adolesc Gynecol 2018 Dec 11. Epub 2018 Dec 11.

Institute of Maternal and Child Research, School of Medicine, University of Chile, Santiago, Chile. Electronic address:

Study Objective: The Androgen Receptor (AR) harbors a variable repeat of a variable number of glutamine residues [(CAG)n] which seems to affect inversely AR transcriptional activity. We assessed whether (CAG)n affect the sequence of the androgen-sensitive pubertal events and body composition in prepubertal girls.

Design: and participants: Nested case-control study within the Growth and Obesity Cohort Study of 1196 low-middle income children (≈50% girls) from Santiago, Chile. Read More

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December 2018
1 Read

A review of lifestyle, metabolic risk factors and blood-based biomarkers for early diagnosis of pancreatic ductal adenocarcinoma.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health|, University of Oxford, Oxford, UK.

We aimed to review the epidemiologic literature examining lifestyle, metabolic risk factors, and blood-based biomarkers including multi-omics (genomics, proteomics, and metabolomics) and to discuss how these predictive markers can inform early diagnosis of pancreatic ductal adenocarcinoma (PDAC). A search of the PubMed database was conducted in June 2018 to review epidemiologic studies of (1) lifestyle and metabolic risk factors for PDAC, genome-wide association studies (GWAS), and risk prediction models incorporating these factors and (2) blood-based biomarkers for PDAC (conventional diagnostic markers, metabolomics, and proteomics). Prospective cohort studies have reported at least twenty possible risk factors for PDAC, including smoking, heavy alcohol drinking, adiposity, diabetes, and pancreatitis, but the relative risks (RR) and population attributable fractions of individual risk factors are small (mostly <10%). Read More

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December 2018
1 Read

Waist circumference and abdominal volume index are the strongest anthropometric discriminators of metabolic syndrome in Spanish adolescents.

Eur J Clin Invest 2018 Dec 14:e13060. Epub 2018 Dec 14.

Department of Nursing, University of Granada, Av. Ilustración, 60, 18016, Granada, Spain.

Background: Waist circumference has been suggested as predictor for metabolic syndrome (MetS) in adolescents but it has not been compared with newly proposed anthropometric indexes. This study aimed to disclose the capacity of ten classic and novel anthropometric indexes to discriminate by the presence of MetS in this young population.

Materials And Methods: A cross-sectional study was performed on 981 adolescents (13. Read More

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December 2018

Global patterns in excess body weight and the associated cancer burden.

CA Cancer J Clin 2018 Dec 12. Epub 2018 Dec 12.

Scientific Vice President, Surveillance and Health Services Research, American Cancer Society, Atlanta, GA.

The prevalence of excess body weight and the associated cancer burden have been rising over the past several decades globally. Between 1975 and 2016, the prevalence of excess body weight in adults-defined as a body mass index (BMI) ≥ 25 kg/m -increased from nearly 21% in men and 24% in women to approximately 40% in both sexes. Notably, the prevalence of obesity (BMI ≥ 30 kg/m ) quadrupled in men, from 3% to 12%, and more than doubled in women, from 7% to 16%. Read More

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December 2018
2 Reads

TNF, but not hyperinsulinemia or hyperglycemia, is a key driver of obesity-induced monocytosis revealing that inflammatory monocytes correlate with insulin in obese male mice.

Physiol Rep 2018 Dec;6(23):e13937

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.

Inflammation contributes to obesity-related hyperinsulinemia and insulin resistance, which often precede type 2 diabetes. Inflammation is one way that obesity can promote insulin resistance. It is not clear if the extent of obesity, hyperinsulinemia, or hyperglycemia, underpins changes in cellular immunity during diet-induced obesity. Read More

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December 2018

Visceral Adiposity Index is not Superior over Anthropometric Parameters with regards to Inflammation in Healthy Adolescent Girls.

P R Health Sci J 2018 Dec;37(4):195-199

Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.

Objective: Better than simple anthropometric parameters, the visceral adiposity index (VAI) has recently been proposed as a predictor of cardiometabolic risk in adults. However, there are conflicting results on the associations of these parameters in children and adolescents. Therefore, we aimed to estimate this potential relationship between VAI, anthropometric parameters (i. Read More

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December 2018
1 Read

Social Jetlag Is Associated With Adiposity in Children.

Glob Pediatr Health 2018 4;5:2333794X18816921. Epub 2018 Dec 4.

University of South Carolina, Columbia, SC, USA.

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December 2018

Relationship Between Obesity, Physical Activity, and Cardiorespiratory Fitness Levels in Children and Adolescents in Bosnia and Herzegovina: An Analysis of Gender Differences.

Front Physiol 2018 28;9:1734. Epub 2018 Nov 28.

Department for Health Sciences, Faculty of Human Sciences, Mid Sweden University, Sundsvall, Sweden.

This study aimed to examine: (i) the level of physical activity (PA), obesity indices and cardiorespiratory fitness (CRF) among boys and girls in primary school, and (ii) to determine the association of obesity indices and PA with CRF for the total number of participants, and then separately for boys and girls. 753 sixth to ninth grade girls and boys aged 10-14 years took part in this cross-sectional study. The PA was assessed by the "Physical Activity Questionnaire - Children" and CRF was assessed by the Maximal multistage a 20 m shuttle run test. Read More

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November 2018
1 Read

Liver Fat Content and Body Fat Distribution in Youths with Excess Adiposity.

J Clin Med 2018 Dec 7;7(12). Epub 2018 Dec 7.

Centro de Estudios Para la Medición de la Actividad Física CEMA, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá 111221, Colombia.

This study had two main objectives: To examine the association between body fat distribution and non-alcoholic fatty liver disease (NAFLD) and liver fat content, and to determine whether the relationship between NAFLD and regional body fat distribution, with respect to liver fat content in youths with excess adiposity, is independent of cardiorespiratory fitness (CRF) and a healthy diet. Liver fat content (controlled attenuation parameter (CAP)), body fat distribution (body mass index (BMI) -score, waist circumference, waist-to-height ratio, fat mass/height, body fat percentage, total fat mass, android-to-gynoid fat mass ratio, visceral adipose tissue (VAT), and lean mass index, determined by dual-energy X-ray absorptiometry (DXA)), CRF (20-m shuttle-run test), and healthy diet (adherence to the Mediterranean diet by KIDMED questionnaire) were measured in 126 adolescents (66% girls) aged between 11 and 17 years. Participants were assigned to two groups according to the presence or absence of hepatic steatosis (CAP values ≥225 dB/m or <225 dB/m of liver fat, respectively). Read More

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December 2018

The impact of abdominal fat on abdominal aorta calcification measured on non-enhanced CT.

Medicine (Baltimore) 2018 Dec;97(49):e13233

Department of Radiology, Hillel Yaffe Medical Center, Hadera, Affiliated with the Faculty of Medicine, Technion- Israel Institute of Technology, Haifa, Israel.

Cardiovascular (CV) morbidity, atherosclerosis, and obesity are all targets of clinical concern and vast research, as is the association between them. Aim of this study is to assess the impact of adipose tissue (including visceral and subcutaneous fat) on abdominal aorta calcification measured on non-enhanced computed tomography (CT). We retrospectively included 492 patients who underwent non-enhanced CT scans during workup for clinically suspected renal colic. Read More

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December 2018
1 Read

Sex differences in inflammatory responses to adipose tissue lipolysis in diet-induced obesity.

Endocrinology 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics and Communicable Disease, University of Michigan Medical School, Ann Arbor, MI.

Males are known to have profound adipose tissue macrophage (ATM) accumulation in gonadal white adipose tissue (GWAT) during obesity, while females are protected from such an inflammatory response even with increased adiposity. The inflammatory tone in males is linked to insulin resistance and might be the underlying cause for sex differences in metabolic disease. Factors regulating the meta-inflammatory response remain unclear but enhanced lipid storage in females may explain the reduced inflammatory response to high fat diets. Read More

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December 2018

Dietary fish oil supplementation during early pregnancy in rats on a cafeteria-diet prevents fatty liver in adult male offspring.

Food Chem Toxicol 2018 Dec 10. Epub 2018 Dec 10.

Department of Chemistry and Biochemistry, Universidad San Pablo CEU, Madrid, Spain. Electronic address:

We studied in rats the effects of cafeteria diet (CD) supplemented (or not) with fish oil (FO) during just the first 12 days of pregnancy, or during the whole of pregnancy and lactation in 14-month old offspring. Female rats were given standard diet (STD) or CD and after mating some animals remained on STD or CD; for some CD rats the diet was supplemented with 8.78% FO. Read More

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December 2018

Relationship of body mass index and waist circumference with clinical outcomes following percutaneous coronary intervention.

PLoS One 2018 13;13(12):e0208817. Epub 2018 Dec 13.

Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.

Background: A biphasic, U-shape relationship has been reported between body mass index (BMI) and clinical outcomes following percutaneous coronary intervention (PCI). However, the relationship between waist circumference (WC) and the cardiovascular risk following PCI has not been reported.

Methods: A prospective cohort study was performed. Read More

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December 2018

Early life adiposity and telomere length across the life course: a systematic review and meta-analysis.

Wellcome Open Res 2017 18;2:118. Epub 2017 Dec 18.

MRC Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK.

: The relationship between adiposity at birth and in childhood, and telomere length is yet to be determined. We aimed to systematically review and meta-analyse the results of studies assessing associations between neonatal and childhood adiposity, and telomere length. : We searched Medline, EMBASE and PubMed for studies reporting associations between adiposity measured in the neonatal period or childhood, and leucocyte telomere length, measured at any age via quantitative polymerase chain reaction, or terminal restriction fragment analysis, either cross-sectionally, or longitudinally. Read More

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December 2017

Molecular Modulation of Osteoblasts and Osteoclasts in Type 2 Diabetes.

J Diabetes Res 2018 4;2018:6354787. Epub 2018 Nov 4.

Department of Health and Biomedical Sciences, College of Health Affairs, University of Texas Rio Grande Valley, 1201, W University Dr, Edinburg, TX 78539, USA.

Diabetes is a common disease affecting majority of populations worldwide. Since 1980, there has been an increase in the number of people diagnosed as prediabetic and diabetic. Diabetes is characterized by high levels of circulating glucose and leads to most microvascular and macrovascular complications such as retinopathy, nephropathy, neuropathy, stroke, and myocardial infarction. Read More

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November 2018

Developing a patient-centered outcome for targeting early childhood obesity across multiple stakeholders.

BMC Obes 2018 3;5:39. Epub 2018 Dec 3.

3Latino Research Initiative, University of Texas at Austin, Austin, TX USA.

Background: Patient-centered outcome measures for childhood obesity are limited. Identifying outcomes that patients and families consider important could be a viable avenue for better engagement of patients and interventions that are efficacious and acceptable to patients. Latino children experience high rates of obesity, and under-recognition of obesity in preschool aged children is common. Read More

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December 2018

Discriminative ability of adiposity measures for elevated blood pressure among adolescents in a resource-constrained setting in northeast Nigeria: a cross-sectional analysis.

BMC Obes 2018 3;5:35. Epub 2018 Dec 3.

4Paediatric Cardiology Unit, Department of Paediatrics, Jos University Teaching Hospital (JUTH), Jos, Nigeria.

Background: Several studies examining the association and discriminative ability of adiposity measures for prehypertension and hypertension among adolescents have reported varying outcomes. We aimed to determine the discriminative ability of the Body Mass index (BMI), Waist Circumference (WC), and Waist-to-Height Ratio (WHtR) adiposity measures for elevated blood pressure (prehypertension and hypertension combined) among adolescents in Gombe, northeast Nigeria.

Methods: This cross-sectional study used a multi-stage sampling technique and involved 367 secondary school adolescent (10-18 years) boys and girls in Gombe Local Government Area, Gombe State, northeast Nigeria from January to September 2015. Read More

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December 2018

Serum Markers of Inflammation Mediate the Positive Association Between Neuroticism and Depression.

Front Psychiatry 2018 20;9:609. Epub 2018 Nov 20.

Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany.

The personality trait neuroticism has been implicated in a poor response to stress, may relate to increased concentrations of cytokines and the development of depression. Inflammatory mechanisms may also be associated with the onset, severity and symptoms of depression. Both are related to poor antidepressant treatment outcome. Read More

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November 2018

Different Statistical Approaches to Characterization of Adipocyte Size in Offspring of Obese Rats: Effects of Maternal or Offspring Exercise Intervention.

Front Physiol 2018 15;9:1571. Epub 2018 Nov 15.

Reproductive Biology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Adipocyte size (AS) shows asymmetric distribution related to current metabolic state, e.g., adipogenesis or lipolysis. Read More

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November 2018

The ColoCare Study - A paradigm of transdisciplinary science in colorectal cancer outcomes.

Cancer Epidemiol Biomarkers Prev 2018 Dec 6. Epub 2018 Dec 6.

Surgery, University of Heidelberg.

Background: Colorectal cancer (CRC) is a leading cause of cancer death. Biomarkers to predict treatment outcomes are needed, as is evidence whether post-diagnosis diet and lifestyle can affect well-being and clinical outcomes. The international ColoCare Consortium aims to identify new biologic markers (e. Read More

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December 2018

The partial inhibition of hypothalamic IRX3 exacerbates obesity.

EBioMedicine 2018 Dec 3. Epub 2018 Dec 3.

Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, State University of Campinas (UNICAMP), Brazil. Electronic address:

Background: The Iroquois homeobox 3 (Irx3) gene has been identified as a functional long-range target of obesity-associated variants within the fat mass and obesity-associated protein (FTO) gene. It is highly expressed in the hypothalamus, and both whole-body knockout and hypothalamic restricted abrogation of its expression results in a lean phenotype, which is mostly explained by the resulting increased energy expenditure in the brown adipose tissue. Because of its potential implication in the pathogenesis of obesity, we evaluated the hypothalamic cell distribution of Irx3 and the outcomes of inhibiting its expression in a rodent model of diet-induced obesity. Read More

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December 2018

Skeletal phenotype of the neuropeptide Y knockout mouse.

Neuropeptides 2018 Nov 30. Epub 2018 Nov 30.

Department of Reconstructive Sciences, Farmington, CT 06030, USA. Electronic address:

Neuropeptide Y (NPY) is involved in multiple processes such as behavior, energy and bone metabolism. Previous studies have relied on global NPY depletion to examine its effects on bone. However, this approach is unable to distinguish the central or local source of NPY influencing bone. Read More

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November 2018
2.546 Impact Factor

An exploration of the longitudinal relation between parental feeding practices and child anthropometric adiposity measures from the West Midlands Active Lifestyle and Healthy Eating in Schoolchildren (WAVES) Study.

Am J Clin Nutr 2018 Dec;108(6):1316-1323

Institute of Applied Health Research, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

Background: Some research suggests that parent or carer feeding practices may influence children's weight patterns, but longitudinal evidence is limited and inconsistent.

Objective: The aim of this study was to investigate the relation between various parent or carer feeding practices when a child is aged 7-8 y and proxy measurements of child adiposity at age 8-9 y (weight status, waist-to-height ratio, and body fat percentage).

Design: The study was a secondary analysis of data from the West Midlands Active Lifestyle and Healthy Eating in Schoolchildren (WAVES) Study comprising a diverse sample of parents and carers and their children from 54 primary schools in the West Midlands, England [n = 774 parent-child dyads (53% of the WAVES study sample)]. Read More

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December 2018
1 Read

Lateral hypothalamic Mc3R-expressing neurons modulate locomotor activity, energy expenditure and adiposity in male mice.

Endocrinology 2018 Dec 11. Epub 2018 Dec 11.

Dept. of Pediatrics, Division of Endocrinology, Michigan Medicine, Ann Arbor, MI.

The central melanocortin (Mc) system plays a crucial role in the control of energy balance. While the decreased energy expenditure and increased adiposity of Mc-3 receptor (Mc3R)-null mice suggest the importance of Mc3R-regulated neurons in energy homeostasis, the roles for specific subsets of Mc3R neurons in energy balance have yet to be determined. Because the lateral hypothalamic area (LHA) contributes to the control of energy expenditure and feeding, we generated Mc3rcre mice to determine the roles of LHA Mc3R (Mc3RLHA) neurons in energy homeostasis. Read More

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December 2018
1 Read

Body mass index and body fat percentage in assessing obesity: An analytical study among the adolescents of Dibrugarh, Assam.

Indian J Public Health 2018 Oct-Dec;62(4):277-281

Professor, Department of Community Medicine, Gauhati Medical College, Guwahati, Assam, India.

Background: Body mass index (BMI) is one of the most commonly used indices to measure the weight status of an individual. However, it takes only height and weight of individual into account. The relative body composition can be calculated regardless of height and weight by body fat percentage (BF%). Read More

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December 2018

Association of Early Life Exposure to Phthalates With Obesity and Cardiometabolic Traits in Childhood: Sex Specific Associations.

Front Public Health 2018 27;6:327. Epub 2018 Nov 27.

Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.

Few studies have investigated longitudinal associations between early life phthalate exposure and subsequent obesity and cardiovascular risks in children with inconsistent results. We aimed to evaluate the associations between phthalate exposure during gestation and childhood with offspring obesity and cardiometabolic risk factors in 500 mother-child pairs from the Rhea pregnancy cohort in Crete, Greece. Seven phthalate metabolites [monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono-isobutyl phthalate (MiBP), monobenzyl phthalate (MBzP), mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)] were quantified in spot urine samples collected from mothers (1st trimester) and their children at 4 years of age. Read More

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November 2018

Associations between reliable changes in depression and changes in BMI, total body fatness and visceral adiposity during a 12-month weight loss trial.

Int J Obes (Lond) 2018 Dec 11. Epub 2018 Dec 11.

Department of Family Medicine and Public Health UC San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.

We investigated associations between changes in depression and body composition over a 12-month weight loss trial. Of the 298 adults (BMI > 27 m/kg), 219 with complete depression and body composition data were included. A 10-item Center for Epidemiologic Studies Depression Scale measured depression; dual-energy X-ray absorptiometry measured body composition. Read More

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December 2018

Ageing influences the relationship of circulating miR-33a and miR- 33b levels with insulin resistance and adiposity.

Diab Vasc Dis Res 2018 Dec 11:1479164118816659. Epub 2018 Dec 11.

1 Instituto de Investigación en Reumatología y del Sistema Musculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.

Objective:: The identification of circulating microRNAs related to abnormal metabolic function may be useful in the context of ageing, adiposity and insulin resistance. The miR-33 a/b has been shown to control the expression of genes involved in fatty acid biosynthesis, impaired metabolism and insulin resistance. In this study, we aimed to identify differences in circulating miR-33 a/b levels according to age-related metabolic impairment and increased adiposity. Read More

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December 2018

Physical activity energy expenditure and cardiometabolic health in three rural Kenyan populations.

Am J Hum Biol 2018 Dec 10:e23199. Epub 2018 Dec 10.

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Objectives: Physical activity is beneficial for metabolic health but the extent to which this may differ by ethnicity is still unclear. Here, the objective was to characterize the association between physical activity energy expenditure (PAEE) and cardiometabolic risk among the Luo, Kamba, and Maasai ethnic groups of rural Kenya.

Methods: In a cross-sectional study of 1084 rural Kenyans, free-living PAEE was objectively measured using individually-calibrated heart rate and movement sensing. Read More

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December 2018
1 Read

Initial evidence for hypothalamic gliosis in children with obesity by quantitative T2 MRI and implications for blood oxygen-level dependent response to glucose ingestion.

Pediatr Obes 2018 Dec 10:e12486. Epub 2018 Dec 10.

Department of Pediatrics, School of Medical Sciences, University of Campinas, Campinas, Brazil.

Objective: In adults, hypothalamic gliosis has been documented using quantitative T2 neuroimaging, whereas functional magnetic resonance imaging (fMRI) has shown a defective hypothalamic response to nutrients. No studies have yet evaluated these hypothalamic abnormalities in children with obesity.

Methods: Children with obesity and lean controls underwent quantitative MRI measuring T2 relaxation time, along with continuous hypothalamic fMRI acquisition to evaluate early response to glucose ingestion. Read More

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December 2018

[Speech and Language Disorders in the Elderly].

Authors:
Arno Olthoff

Laryngorhinootologie 2018 Dec 10;97(12):846-851. Epub 2018 Dec 10.

Phoniatrie und Pädaudiologie Göttingen, Klinik für Hals-, Nasen- und Ohrenheilkunde.

Cerebrovascular insults and neurodegenerative diseases are the main causes of acquired speech and language disorders. A massive increase in the prevalence of both is evident from the age of 65 years. By the age of 90 years, more than 10 % of the population would have experienced a stroke and 30 % would have suffered from neurodegenerative diseases. Read More

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December 2018

Changes in Body Adiposity, Dietary Intake, Physical Activity and Quality of Life of Obese Individuals Submitted to Intragastric Balloon Therapy for 6 Months.

Obes Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Applied Nutrition, Nutrition Institute, Rio de Janeiro State University, 12th floor/524, São Francisco Xavier Street, Rio de Janeiro, RJ, 20550-900, Brazil.

Background: Obesity is an important risk factor for several chronic diseases and also is associated with worse quality of life. Intragastric balloon (IGB) is an effective method for weight loss. Although changes in lifestyle are critical to weight loss during and after IGB therapy, only a few studies evaluated dietary intake and none evaluated changes in physical activity with a validated questionnaire during the treatment. Read More

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December 2018

The Association of Polyunsaturated Fatty Acid δ-5-Desaturase Activity with Risk Factors for Type 2 Diabetes Is Dependent on Plasma ApoB-Lipoproteins in Overweight and Obese Adults.

J Nutr 2018 Dec 10. Epub 2018 Dec 10.

Faculty of Medicine, Université de Montréal, Montréal, Québec.

Background: δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n-3 (ω-3) and n-6 (ω-6) polyunsaturated fatty acids (PUFAs). Their activities are negatively and positively associated with type 2 diabetes (T2D), respectively, by unclear mechanisms. Elevated plasma apoB-lipoproteins (measured as plasma apoB), which can be reduced by n-3 PUFA intake, promote T2D risk factors. Read More

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December 2018

Association of Breathing Reserve at Peak Exercise with Body Composition and Physical Function in Older Adults with Obesity.

J Gerontol A Biol Sci Med Sci 2018 Dec 8. Epub 2018 Dec 8.

Section on Gerontology and Geriatric Medicine, Department of Internal Medicine.

Background: Adiposity-related ventilatory constraints in older adults can potentially contribute to greater risk of exercise intolerance and mobility disability. This study investigated whether ventilatory limitation, measured by breathing reserve at peak exercise (BR), is associated with body composition and physical function in older adults with obesity.

Methods: This study was a cross-sectional analysis of data from a community-based cohort (n=177) of older men and women (65-79 years) with obesity (BMI=30-45 kg/m 2). Read More

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December 2018

Association of Age-Related Trends in Blood Pressure and Body Composition Indices in Healthy Adults.

Front Physiol 2018 26;9:1574. Epub 2018 Nov 26.

School of Basic Medicine, Capital Medical University, Beijing, China.

Adiposity is one of the important determinants of blood pressure. The aim of this study is to evaluate the association between blood pressure and body composition indices throughout the whole lifespan of healthy adults. This study was from an ongoing cross-sectional survey of the Chinese health wherein data included basic physiological parameters. Read More

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November 2018
1 Read

The depot-specific and essential roles of CBP/p300 in regulating adipose plasticity.

J Endocrinol 2019 Feb;240(2):257-269

Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.

Fat remodeling has been extensively explored through protein deacetylation, but not yet acetylation, as a viable therapeutic approach in the management of obesity and related metabolic disorders. Here, we investigated the functions of key acetyltransferases CBP/p300 in adipose remodeling and their physiological effects by generating adipose-specific deletion of CBP (Cbp-AKO), p300 (p300-AKO) and double-knockout (Cbp/p300-AKO) models. We demonstrated that Cbp-AKO exhibited marked brown remodeling of inguinal WAT (iWAT) but not epididymal WAT (eWAT) after cold exposure and that this pattern was exaggerated in diet-induced obesity (DIO). Read More

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February 2019

Adiponectin, leptin and high sensitivity C-reactive protein values in obese children - important markers for metabolic syndrome?

J Pediatr Endocrinol Metab 2018 Dec 8. Epub 2018 Dec 8.

Louis Țurcanu Emergency Hospital for Children, Timișoara, Romania.

Background Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C-reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity such as leptin, adiponectin and high sensitivity C-reactive protein (hs-CRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome (MetS) in pediatric population. Methods A cross-sectional study was conducted over a period of 1 year, between July 2013 and June 2014, on 122 cases of obesity in children diagnosed at the Louis Ţurcanu Emergency Hospital for Children Timişoara, in the departments of Diabetes and Nutritional Diseases, Endocrinology and Cardiology. Read More

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December 2018

Exposure to polybrominated diphenyl ethers (PBDEs) during childhood and adiposity measures at age 8 years.

Environ Int 2018 Dec 4;123:148-155. Epub 2018 Dec 4.

Division of Epidemiology, Department of Environmental Health, University of Cincinnati College of Medicine, P.O. Box 670056, Cincinnati, OH 45267, USA.

Background: Animal studies suggest polybrominated diphenyl ethers (PBDEs) may be obesogens. However, epidemiologic studies investigating childhood exposure to PBDEs and adiposity are limited, with several reporting an inverse association.

Objectives: To investigate associations between repeated childhood PBDE concentrations and adiposity measures at age 8 years. Read More

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December 2018

Triponderal mass index rather than body mass index: An indicator of high adiposity in Italian children and adolescents.

Nutrition 2018 Sep 19;60:41-47. Epub 2018 Sep 19.

PhD School of Applied Medical-Surgical Sciences, University of Rome Tor Vergata, Rome, Italy; CAPES Scholarship, CAPES Foundation, Ministry of Education of Brazil, Brasilia, Brazil.

Objective: The aims of this study were to compare body mass index (BMI) and triponderal mass index (TMI) as predictors of fat mass percentage (FM%) and to develop TMI cutoffs for screening high adiposity. Therefore, TMI- and BMI-based references against FM% criterion for indicating adiposity in Italian children and adolescents were compared.

Methods: This was a cross-sectional study conducted at the University of Rome Tor Vergata, Human Nutrition Unit, from 2008 to 2015. Read More

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September 2018

GLP-1 modulates the supramammillary nucleus-lateral hypothalamic neurocircuit to control ingestive and motivated behavior in a sex divergent manner.

Mol Metab 2018 Nov 27. Epub 2018 Nov 27.

Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Sweden. Electronic address:

Objective: The supramammillary nucleus (SuM) is nestled between the lateral hypothalamus (LH) and the ventral tegmental area (VTA). This neuroanatomical position is consistent with a potential role of this nucleus to regulate ingestive and motivated behavior. Here neuroanatomical, molecular, and behavior approaches are utilized to determine whether SuM contributes to ingestive and food-motivated behavior control. Read More

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November 2018

Deletion of the murine ortholog of the 8q24 gene desert has anti-cancer effects in transgenic mammary cancer models.

BMC Cancer 2018 Dec 10;18(1):1233. Epub 2018 Dec 10.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 68 President Street, Charleston, SC, 29425, USA.

Background: The gene desert on human chromosomal band 8q24 harbors multiple genetic variants associated with common cancers, including breast cancer. The locus, including the gene desert and its flanking genes, MYC, PVT1 and FAM84B, is also frequently amplified in human breast cancer. We generated a megadeletion (MD) mouse model lacking 430-Kb of sequence orthologous to the breast cancer-associated region in the gene desert. Read More

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December 2018
3.362 Impact Factor

The Physiology of Optimizing Health with a Focus on Exercise as Medicine.

Annu Rev Physiol 2018 Dec 10. Epub 2018 Dec 10.

Centre of Inflammation and Metabolism/Centre for Physical Activity Research (CIM/CFAS), Rigshospitalet, Unviversity of Copenhagen, DK-2100 Copenhagen, Denmark; email:

Physical inactivity is one of the leading health problems in the world. Strong epidemiological and clinical evidence demonstrates that exercise decreases the risk of more than 35 different disorders and that exercise should be prescribed as medicine for many chronic diseases. The physiology and molecular biology of exercise suggests that exercise activates multiple signaling pathways of major health importance. Read More

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December 2018

Microencapsulated feruloyl esterase-producing lactobacilli ameliorate lipid profile and glycaemia in high fat diet-induced obese mice.

Benef Microbes 2018 Dec 10:1-10. Epub 2018 Dec 10.

1 Centro de Referencia para Lactobacilos (CERELA)-CONICET, Chacabuco 145, T4000ILC, San Miguel de Tucumán, Tucumán, Argentina.

The effect of oral administration of spray-dried microcapsules of feruloyl esterase (FE) producing Lactobacillus fermentum CRL1446 (Lf) and Lactobacillus johnsonii CRL1231 (Lj) on high fat diet-induced obese mice was investigated to evaluate whether these strains could be used as a biotherapeutic for obesity. Swiss albino mice were divided into a normal diet fed group receiving empty microcapsules (control), a high fat diet plus empty microcapsules (HFD group), HFD plus microcapsules with Lf (HFD-Lf group) and HDF plus microcapsules with Lj (HFD-Lj group). Microcapsules containing Lf or Lj at a dose of ~10 cells/day/mouse were given orally for 7 weeks. Read More

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December 2018

Enhanced anxiety-like behavior emerges with weight gain in male and female obesity-susceptible rats.

Behav Brain Res 2018 Dec 3;360:81-93. Epub 2018 Dec 3.

Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA; Department of Biology, Hope College, Holland, MI, USA; Department of Biomedical Sciences, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, USA. Electronic address:

Epidemiological data suggest that body mass index and obesity are strong risk factors for depression and anxiety. However, it is difficult to separate cause from effect, as predisposition to obesity may enhance susceptibility to anxiety, or vice versa. Here, we examined the effect of diet and obesity on anxiety-like behaviors in male and female selectively bred obesity-prone and obesity-resistant rats, and outbred Sprague-Dawley rats. Read More

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December 2018
2 Reads

Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.

Cochrane Database Syst Rev 2018 11 30;11:CD003177. Epub 2018 Nov 30.

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, Norfolk, UK, NR4 7TJ.

Background: Researchers have suggested that omega-3 polyunsaturated fatty acids from oily fish (long-chain omega-3 (LCn3), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)), as well as from plants (alpha-linolenic acid (ALA)) benefit cardiovascular health. Guidelines recommend increasing omega-3-rich foods, and sometimes supplementation, but recent trials have not confirmed this.

Objectives: To assess effects of increased intake of fish- and plant-based omega-3 for all-cause mortality, cardiovascular (CVD) events, adiposity and lipids. Read More

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November 2018
9 Reads

Mediation of Associations Between Adiposity and Colorectal Cancer Risk by Inflammatory and Metabolic Biomarkers.

Int J Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.

Inflammation and hyperinsulinemia may drive associations between adiposity and colorectal cancer (CRC) risk, but few studies have examined this hypothesis using mediation analysis. We used inverse odds ratio weighting and logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI) for estimated total effects (OR ) of body mass index, waist circumference, and adult weight gain on CRC risk, and estimated effects operating through seven inflammatory and metabolic biomarkers (natural indirect effect; OR ) or through paths independent of these biomarkers (natural direct effect; OR ) among 209 CRC cases and 382 matched controls nested within the Health Professionals Follow-up Study, a prospective cohort of male health professionals. A one-interquartile range (IQR) increase in body mass index (3. Read More

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December 2018
3 Reads

Normal Weight Adiposity and Postmenopausal Breast Cancer Risk.

JAMA Oncol 2018 Dec 6. Epub 2018 Dec 6.

Division of Medical Oncology and Hematology, Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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December 2018
1 Read