325 results match your criteria Adipocyte[Journal]


Adipocytes as lipid sensors of oleic acid transport through a functional Caco-2/HT29-MTX intestinal barrier.

Adipocyte 2019 Mar 23:1-15. Epub 2019 Mar 23.

a CarMeN Laboratory, INRA UMR1397, INSERM U1060, INSA-Lyon, IMBL , Université Lyon 1 , Lyon , France.

Adipose tissue function in the regulation of lipemia is highly dependent on intestinal absorption of nutrients. Therefore the aim of the present study was the development and validation of an in vitro multiculture model allowing to measure intestinal absorption using adipocytes as lipid sensors. We previously described (1) novel methods to study oleic acid induction of adipogenesis and lipogenesis and (2) a functional reconstituted intestinal barrier using human cell lines Caco-2/HT29-MTX (9:1). Read More

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http://dx.doi.org/10.1080/21623945.2019.1580842DOI Listing

Transcriptome profiling reveals association of peripheral adipose tissue pathology with type-2 diabetes in Asian Indians.

Adipocyte 2019 Mar 20:1-12. Epub 2019 Mar 20.

b Department of Endocrinology , Sawai Man Singh Medical College and Hospital , Jaipur , India.

Type 2 diabetes (T2D) is a complex disease with an elusive link between its molecular aetiology and clinical presentation. Although, the role of visceral adipose tissue in insulin-resistance and T2D is known, limited information is available on the role of peripheral-subcutaneous adipose tissue especially in Asian Indians. In this microarray-based study of diabetic and normal glucose tolerant Asian Indians, we generated the transcriptome of their thigh adipose tissue and analyzed differentially expressed genes (DEGs) using weighted gene co-expression network analysis; further we identified perturbed pathways implicated by these DEGs in relevant co-expression modules. Read More

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http://dx.doi.org/10.1080/21623945.2019.1595269DOI Listing

Effects of ADIPOQ polymorphisms on individual susceptibility to coronary artery disease: a meta-analysis.

Adipocyte 2019 Mar 16:1-7. Epub 2019 Mar 16.

b Department of Cardiology , Qilu Hospital of Shandong University , Jinan , China.

Whether adiponectin (ADIPOQ) polymorphisms affect individual susceptibility to coronary artery disease (CAD) remains controversial. Therefore, we performed this meta-analysis to better analyse associations between ADIPOQ polymorphisms and CAD. PubMed, Web of Science, Embase and CNKI were searched for eligible studies. Read More

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http://dx.doi.org/10.1080/21623945.2019.1595270DOI Listing
March 2019
1 Read

Advanced-age C57BL/6JRj mice do not develop obesity upon western-type diet exposure.

Adipocyte 2019 Mar 12:1-9. Epub 2019 Mar 12.

a Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences , KU Leuven , Leuven , Belgium.

Obesity has become a global health-threat for every age group. It is well known that young mice (10-12 weeks of age) fed a western-type diet (WD) become obese and develop higher cholesterol levels and liver steatosis whereas insulin sensitivity is reduced. Less is known, however, about the effect of a WD on advanced-age mice. Read More

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http://dx.doi.org/10.1080/21623945.2019.1590893DOI Listing
March 2019
4 Reads

KD025 (SLx-2119) suppresses adipogenesis at intermediate stage in human adipose-derived stem cells.

Adipocyte 2019 Mar 12:1-11. Epub 2019 Mar 12.

a Gachon Institute of Pharmaceutical Sciences, College of Pharmacy , Gachon University , Incheon , Republic of Korea.

Rho-associated kinases (ROCKs) have been reported to antagonize adipocyte differentiation, and inhibition of ROCKs by small molecules promotes adipogenesis. Surprisingly, our recent study revealed that the ROCK2-specific inhibitor KD025 (SLx-2119), suppresses differentiation at the intermediate stage in 3T3-L1 preadipocytes. To address whether the anti-adipogenic activity of KD025 is a generalizable property, we examined the effect of KD025 in human adipose-derived stem cells (hADSCs). Read More

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http://dx.doi.org/10.1080/21623945.2019.1590929DOI Listing
March 2019
8 Reads

Harnessing adipogenesis to prevent obesity.

Adipocyte 2019 Mar 8:1-7. Epub 2019 Mar 8.

a Division of Experimental Medicine, Department of Medicine , McGill University and The Research Institute of McGill University Health Centre , Montreal , Quebec , Canada.

Obesity and associated metabolic complications, including diabetes, cardiovascular and hepatic diseases, and certain types of cancers, create a major socioeconomic burden. Obesity is characterized by excessive expansion of white adipose tissue resulting from increased adipocyte size, and enhanced adipocyte precursor cells proliferation and differentiation into mature adipocytes, a process well-defined as adipogenesis. Efforts to develop therapeutically potent strategies to circumvent obesity are impacted by our limited understanding of molecular mechanisms regulating adipogenesis. Read More

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http://dx.doi.org/10.1080/21623945.2019.1583037DOI Listing

Maintaining mitochondria in beige adipose tissue.

Authors:
Xiaodan Lu

Adipocyte 2019 Jan 27:1-6. Epub 2019 Jan 27.

a Medical Diagnostic Research Center , Jilin Province People's Hospital , Changchun , Jilin , China.

Individual cell types vary enormously in the amount of different organelles they contain. One such organelle is the mitochondrion. Understanding how mitochondrial levels are controlled is essential since so many disease states seem to involve mitochondrial function. Read More

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http://dx.doi.org/10.1080/21623945.2019.1574194DOI Listing
January 2019

Higher lactate production from glucose in cultured adipose nucleated stromal cells than for rat adipocytes.

Adipocyte 2019 Jan 24:1-16. Epub 2019 Jan 24.

a Department of Biochemistry and Molecular Biomedicine , Faculty of Biology University of Barcelona , Barcelona , Spain.

White adipose tissue (WAT) nucleated stromal cells (NSC) play important roles in regulation, defense, regeneration and metabolic control. In WAT sites, the proportions and functions of NSC change under diverse physiological or pathologic conditions. We had previously observed the massive anaerobic wasting of glucose to lactate and glycerol in rat epididymal adipocytes. Read More

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http://dx.doi.org/10.1080/21623945.2019.1569448DOI Listing
January 2019
1 Read

Leptin stimulates autophagy/lysosome-related degradation of long-lived proteins in adipocytes.

Adipocyte 2019 Jan 24:1-10. Epub 2019 Jan 24.

a Department of Clinical Biochemistry and Pharmacology , Ben-Gurion University of the Negev , Beer-Sheva , Israel.

Obesity, a condition most commonly associated with hyper-leptinemia, is also characterized by increased expression of autophagy genes and likely autophagic activity in human adipose tissue (AT). Indeed, circulating leptin levels were previously shown to positively associate with the expression levels of autophagy genes such as Autophagy related gene-5 (ATG5). Here we hypothesized that leptin acts in an autocrine-paracrine manner to increase autophagy in two major AT cell populations, adipocytes and macrophages. Read More

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http://dx.doi.org/10.1080/21623945.2019.1569447DOI Listing
January 2019

Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumour progression.

Adipocyte 2018 Nov 24. Epub 2018 Nov 24.

a Department of Breast and Thyroid Surgery , Renmin Hospital of Wuhan University , Wuhan , Hubei , P. R. China.

Emerging evidence supports the pivotal roles of cancer-associated cachexia in biological behaviour of breast cancer. However, the mediators and mechanisms that mediate cancer-induced cachexia remain unclear. Here, we show that breast cancer-derived exosomes alter adipocytes and muscle cells in terms of increased catabolism characterized by the release of metabolites. Read More

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http://dx.doi.org/10.1080/21623945.2018.1551688DOI Listing
November 2018
1 Read

Brown adipose tissue and glucose homeostasis - the link between climate change and the global rise in obesity and diabetes.

Adipocyte 2018 Nov 21. Epub 2018 Nov 21.

a Early Life Research Unit, Division of Child Health , Obstetrics & Gynaecology, School of Medicine, University of Nottingham , Nottingham , UK.

There is increasing evidence that the global rise in temperature is contributing to the onset of diabetes, which could be mediated by a concomitant reduction in brown fat activity. Brown (and beige) fat are characterised as possessing a unique mitochondrial protein uncoupling protein (UCP)1 that when activated can rapidly generate large amounts of heat. Primary environmental stimuli of UCP1 include cold-exposure and diet, leading to increased activity of the sympathetic nervous system and large amounts of lipid and glucose being oxidised by brown fat. Read More

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http://dx.doi.org/10.1080/21623945.2018.1551689DOI Listing
November 2018
11 Reads

Elucidating the role of Lkb1 and mTOR in adipose tissue.

Adipocyte 2018 Oct 14:1-5. Epub 2018 Oct 14.

a Institute of Feed Science, College of Animal Sciences , Zhejiang University , Hangzhou , Zhejiang , China.

Adipose tissues, function as energy metabolism and endocrine organ, are closely associated with metabolic diseases such as obesity, insulin resistance and diabetes. Liver kinase B1 (Lkb1) and mechanistic target of rapamycin (mTOR) play crucial roles in regulating energy metabolism and cell growth in adipose tissue. Our recent study generated an adipocyte-specific Lkb1 and mTOR double knockout (DKO) mouse model and found that DKO of Lkb1 and mTOR caused reduction of brown adipose tissue (BAT) and inguinal white adipose tissue (iWAT) mass but increase of liver mass. Read More

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https://www.tandfonline.com/doi/full/10.1080/21623945.2018.1
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http://dx.doi.org/10.1080/21623945.2018.1535743DOI Listing
October 2018
23 Reads

Proliferation of nutrition sensing preadipocytes upon short term HFD feeding.

Adipocyte 2018 Sep 29:1-10. Epub 2018 Sep 29.

a Institute of Food Nutrition and Health , Eidgenössische Technische Hochschule Zürich (ETH) , Schwerzenbach , Switzerland.

Adipose tissue is highly dynamic and increases its size dependent on the status of nutrition. Generally, an increase of adipose tissue mass is attributed to two mechanisms, namely hypertrophy (increase in adipocyte size) and hyperplasia (increase in adipocyte number). Here, we analyzed the proliferation capacity of a pool of nutrition sensing preadipocytes after short-term high fat diet (HFD) feeding. Read More

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http://dx.doi.org/10.1080/21623945.2018.1521229DOI Listing
September 2018

Acylated and unacylated ghrelin directly regulate ß-3 stimulated lipid turnover in rodent subcutaneous and visceral adipose tissue ex vivo but not in vivo.

Adipocyte 2018 Sep 28:1-15. Epub 2018 Sep 28.

a Department of Human Health and Nutritional Sciences , University of Guelph , Guelph , Ontario , Canada.

Ghrelin has garnered interest as a gut-derived regulator of lipid metabolism, beyond its classical roles in driving appetite and growth hormone release. Ghrelin's circulating concentrations follow an ultradian rhythm, peak immediately before a meal and point towards a potential metabolic role in reducing the mobilization of fatty acid stores in preparation for the storage of ingested food. Here, we demonstrate that both acylated and unacylated ghrelin have physiological roles in attenuating lipolysis in mature subcutaneous and visceral adipose tissue depots of rats. Read More

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http://dx.doi.org/10.1080/21623945.2018.1528811DOI Listing
September 2018
2 Reads

Adipose tissue and body composition in women six years after gestational diabetes: factors associated with development of type 2 diabetes.

Adipocyte 2018 30;7(4):229-237. Epub 2018 Sep 30.

a Department of Clinical Chemistry and Transfusion Medicine , Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.

Factors differentiating women at highest risk of progression to type 2 diabetes mellitus (T2DM) after gestational diabetes mellitus (GDM) are incompletely known. Our aim was to characterize adipose tissue and body composition in relation to glucose metabolism in women with a history of GDM and to identify factors associated with development of T2DM. We examined glucose tolerance (OGTT), insulin sensitivity (HOMA-IR), body composition (anthropometry, air displacement plethysmography), and blood chemistry in 39 women 6 years after GDM. Read More

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https://www.tandfonline.com/doi/full/10.1080/21623945.2018.1
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http://dx.doi.org/10.1080/21623945.2018.1521230DOI Listing
September 2018
4 Reads

CD24 is required for regulating gene expression, but not glucose uptake, during adipogenesis.

Adipocyte 2018 2;7(4):248-260. Epub 2018 Oct 2.

a Department of Biochemistry , Memorial University of Newfoundland , St. John's , Canada.

Adipose tissue dysfunction in obesity and lipodystrophy results in major health complications such as heart disease and stroke, and is associated with an increased risk of some cancers. We have previously found that the cell surface receptor CD24 regulates adipogenesis as measured by lipid accumulation and gene expression in mature adipocytes. How CD24 regulates these processes remains unknown. Read More

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https://www.tandfonline.com/doi/full/10.1080/21623945.2018.1
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http://dx.doi.org/10.1080/21623945.2018.1525251DOI Listing
October 2018
19 Reads

Subcutaneous adipose tissue accumulation protects systemic glucose tolerance and muscle metabolism.

Adipocyte 2018 30;7(4):261-272. Epub 2018 Sep 30.

a Department of Food Science and Human Nutrition , Colorado State University , Fort Collins , CO , USA.

The protective effects of lower body subcutaneous adiposity are linked to the depot functioning as a "metabolic sink" receiving and sequestering excess lipid. This postulate, however, is based on indirect evidence. Mechanisms that mediate this protection are unknown. Read More

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https://www.tandfonline.com/doi/full/10.1080/21623945.2018.1
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http://dx.doi.org/10.1080/21623945.2018.1525252DOI Listing
September 2018
1 Read

SGLT6 - A pharmacological target for the treatment of obesity?

Adipocyte 2018 11;7(4):277-284. Epub 2018 Oct 11.

a CardioMetabolic Diseases Research , Boehringer-Ingelheim Pharma GmbH & Co. KG , Biberach an der Riss , Germany.

Despite increased knowledge of nutrient intake regulation and energy homeostasis, treatment options for obesity remain limited. Food reward consists of two branches: gustatory and post-ingestive nutritive information. Drosophila lacking dSLC5A11 (sodium/glucose cotransporter 6-SGLT6) prefer L-glucose over D-glucose independently of their state of satiety. Read More

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https://www.tandfonline.com/doi/full/10.1080/21623945.2018.1
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http://dx.doi.org/10.1080/21623945.2018.1516098DOI Listing
October 2018
9 Reads

A context-specific circadian clock in adipocyte precursor cells modulates adipogenesis.

Adipocyte 2018 13;7(4):273-276. Epub 2018 Sep 13.

a Department of Pediatrics/Endocrinology , Stanford University School of Medicine , Stanford , CA , USA.

The circadian clock is an intricate molecular network that paces a variety of physiological process to ~ 24 hour day/night cycles. Whereas the central circadian clock in the brain is primarily entrained by light signals, peripheral circadian clocks, which are in most cells in the body, receive cues not only from the central pacemaker but also endocrine and other systemic and tissue-specific signals. Prior studies have connected peripheral circadian clocks to metabolism, primarily with studies focused on the robust clock in the liver that responds to feeding/fasting cycles. Read More

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http://dx.doi.org/10.1080/21623945.2018.1516099DOI Listing
September 2018

Role of peroxisome proliferator-activated receptor gamma Pro12Ala polymorphism in human adipose tissue: assessment of adipogenesis and adipocyte glucose and lipid turnover.

Adipocyte 2018 14;7(4):285-296. Epub 2018 Aug 14.

a Department of Medical Sciences, Clinical Diabetes and Metabolism , Uppsala University , Uppsala , Sweden.

The protective mechanisms of peroxisome proliferator-activated receptor gamma (PPARγ) Pro12Ala polymorphism in type 2 diabetes (T2D) are unclear. We obtained subcutaneous adipose tissue (AT) before and 3 h after oral glucose (OGTT) in carriers and non-carriers of the Ala allele (12 Pro/Pro, 15 Pro/Ala, and 13 Ala/Ala). Adipogenesis, adipocyte glucose uptake and lipolysis as well as PPARγ target gene expression were investigated and compared between the genotype groups. Read More

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http://dx.doi.org/10.1080/21623945.2018.1503030DOI Listing
August 2018
1 Read

Adiposity and metabolic health in mice deficient in intestinal alkaline phosphatase.

Adipocyte 2018 10;7(3):149-155. Epub 2018 Aug 10.

a Center for Molecular and Vascular Biology , KU Leuven , Leuven , Belgium.

Intestinal alkaline phosphatase 3 (AKP3) is an enzyme that was reported to play a role in lipid metabolism and to prevent high fat diet-induced metabolic syndrome in mice. To investigate a potential functional role of AKP3 in diet-induced adiposity and metabolic health, we have kept male and female wild-type or AKP3 deficient mice on a high fat diet for 15 weeks to induce obesity and compared those with mice kept on standard fat diet. Body weight as well as adipose tissue mass were statistically significantly higher upon high fat diet feeding for mice of both genders and genotypes. Read More

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http://dx.doi.org/10.1080/21623945.2018.1493899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224189PMC
August 2018
2 Reads

Circulating fibroblast growth factor 21 is reduced, whereas its production is increased in a fat depot-specific manner in cold-acclimated rats.

Adipocyte 2018 20;7(4):238-247. Epub 2018 Sep 20.

a Muscle Health Research Center, School of Kinesiology and Health Science , York University , Toronto , Ontario , Canada.

This study investigated the effects of cold acclimation on circulating fibroblast growth factor 21 (FGF21) levels, as well as its production and signaling in classical brown and white adipose tissues. Male Wistar rats were cold (4°C) acclimatized for 7 days. Subsequently, liver, interscapular and aortic BAT (iBAT and aBAT), and the Sc Ing and epididymal (Epid) white adipose tissues were extracted. Read More

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http://dx.doi.org/10.1080/21623945.2018.1504591DOI Listing
September 2018
2 Reads

The role of adipocyte-specific IL-6-type cytokine signaling in FFA and leptin release.

Adipocyte 2018 3;7(3):226-228. Epub 2018 Aug 3.

a Division of Pediatric Endocrinology and Diabetology , University Children's Hospital , Zurich , Switzerland.

High secretion of interleukin (IL)-6 from white adipose tissue may contribute to metabolic complications in obesity. We have recently shown that IL-6-type cytokine signaling in adipocytes is involved in the development of obesity-associated hepatic insulin resistance and steatosis. In addition, we revealed that adipocyte-specific IL-6 signaling ameliorates glucose metabolism in obesity via enhancing insulin secretion. Read More

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http://dx.doi.org/10.1080/21623945.2018.1493901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224188PMC

3D MicroCT spatial and temporal characterization of thoracic aorta perivascular adipose tissue and plaque volumes in the ApoE-/- mouse model.

Adipocyte 2018 9;7(3):156-165. Epub 2018 Aug 9.

a Lupus Center of Excellence, Autoimmunity Institute, Department of Medicine , Allegheny Health Network , Pittsburgh , PA , USA.

Perivascular adipose tissue (PVAT) influences vascular function and pathology. We present a protocol using micro-computed tomography (microCT), a novel imaging technique typically used for hard biological tissue, to characterize the temporal and spatial development of aorta PVAT and luminal plaque soft tissue. Apolipoprotein E deficient (ApoE) and C57Bl/6J (control) mice were fed a high fat western diet up to 30 weeks. Read More

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https://www.tandfonline.com/doi/full/10.1080/21623945.2018.1
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http://dx.doi.org/10.1080/21623945.2018.1493900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224183PMC
August 2018
18 Reads

Free lipid and computerized determination of adipocyte size.

Adipocyte 2018 14;7(3):180-182. Epub 2018 Jul 14.

a Department of Clinical Chemistry and Transfusion Medicine , Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.

The size distribution of adipocytes in a suspension, after collagenase digestion of adipose tissue, can be determined by computerized image analysis. Free lipid, forming droplets, in such suspensions implicates a bias since droplets present in the images may be identified as adipocytes. This problem is not always adjusted for and some reports state that distinguishing droplets and cells is a considerable problem. Read More

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http://dx.doi.org/10.1080/21623945.2018.1489335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224185PMC

Promotion of lipid storage rather than of thermogenic competence by fetal versus newborn calf serum in primary cultures of brown adipocytes.

Adipocyte 2018 16;7(3):166-179. Epub 2018 Jul 16.

a Department of Molecular Biosciences , The Wenner-Gren Institute, Stockholm University , Stockholm , Sweden.

Much current understanding of brown adipocyte development comes from in-vitro cell models. Serum type may affect the behavior of cultured cells and thus conclusions drawn. Here, we investigate effects of serum type ("fetal bovine" versus "newborn calf") on responses to differentiation inducers (the PPARγ agonist rosiglitazone or the neurotransmitter norepinephrine) in cultured primary brown adipocytes. Read More

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http://dx.doi.org/10.1080/21623945.2018.1479578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224186PMC
July 2018
1 Read

Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance.

Adipocyte 2018 9;7(3):218-225. Epub 2018 Aug 9.

a Department of Cell Metabolism and Nutrition , Advanced Preventive Medical Sciences Research Center, Kanazawa University , Kanazawa , Ishikawa , Japan.

Obesity is a low-grade sustained inflammatory state that causes oxidative stress in different metabolic tissues, which leads to insulin resistance and nonalcoholic fatty liver disease (NAFLD). Particularly, obesity-induced metabolic endotoxemia plays an important role in the pathogenesis of insulin resistance and inflammation. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key regulator of antioxidant signaling that serves as a primary cellular defense against the cytotoxic effects of oxidative stress. Read More

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http://dx.doi.org/10.1080/21623945.2018.1474669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261473PMC
August 2018
11 Reads

Gender and age-related cell compositional differences in C57BL/6 murine adipose tissue stromal vascular fraction.

Adipocyte 2018 8;7(3):183-189. Epub 2018 Jun 8.

a LaCell, LLC, New Orleans Bio Innovation Center , New Orleans , LA.

Adipose tissue is now recognized as a functional organ that contains cellular heterogeneity and diversity within anatomical depots. The stromal vascular fraction (SVF) of adipose contains endothelial progenitors, fibroblasts, lymphocytes, monocyte/macrophages, pericytes, pre-adipocytes, and stromal/stem cells, among others. In recent years, there has been a growing appreciation of the influence of age and gender in the field of stem cell biology. Read More

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https://www.tandfonline.com/doi/full/10.1080/21623945.2018.1
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http://dx.doi.org/10.1080/21623945.2018.1460009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224190PMC
June 2018
3 Reads

The effects of polyphenol supplementation on adipose tissue morphology and gene expression in overweight and obese humans.

Adipocyte 2018 22;7(3):190-196. Epub 2018 May 22.

a Department of Human Biology , NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+ , the Netherlands.

Dietary polyphenols have beneficial effects on adipose tissue mass and function in rodents, but human studies are scarce. In a randomized, placebo-controlled study, 25 (10 women) overweight and obese humans received a combination of the polyphenols epigallocatechin-gallate and resveratrol (282 mg/d, 80 mg/d, respectively, EGCG+RES, n = 11) or placebo (PLA, n = 14) supplementation for 12 weeks. Abdominal subcutaneous adipose tissue (SAT) biopsies were collected for assessment of adipocyte morphology and micro-array analysis. Read More

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http://dx.doi.org/10.1080/21623945.2018.1469942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224187PMC
May 2018
31 Reads

Glycemic control and its associated factors among diabetes mellitus patients at Ayder comprehensive specialized hospital, Mekelle-Ethiopia.

Adipocyte 2018 18;7(3):197-203. Epub 2018 May 18.

b Department of Clinical Chemistry , School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar , Northwest Ethiopia.

Diabetes is one of the largest health emergencies of the twenty-first century and it is increasing with alarming rate throughout the world. Glycemic Control in diabetes patients is an important issue in minimizing diabetes related complications and deaths. Institution based comparative cross-sectional study was conducted from March to April, 2017. Read More

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http://dx.doi.org/10.1080/21623945.2018.1467716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224191PMC
May 2018
14 Reads

Use of C-glucose by primary cultures of mature rat epididymal adipocytes. Marked release of lactate and glycerol, but limited lipogenesis in the absence of external stimuli.

Adipocyte 2018 30;7(3):204-217. Epub 2018 Apr 30.

a Department of Biochemistry and Molecular Biomedicine , Faculty of Biology, University of Barcelona , Barcelona , Spain.

White adipose tissue can metabolize large amounts of glucose to glycerol and lactate. We quantitatively traced glucose label to lactate, glycerol and fats in primary cultures of mature rat epididymal adipocytes. Cells were incubated with 7/14 mM C-glucose for 24/48 h. Read More

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http://dx.doi.org/10.1080/21623945.2018.1460020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224184PMC
April 2018
1 Read

Effects of gut microbiota manipulation on ex vivo lipolysis in human abdominal subcutaneous adipocytes.

Adipocyte 2018 25;7(2):106-112. Epub 2018 Apr 25.

a Department of Human Biology , NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+ , ER Maastricht , The Netherlands.

The intestinal microbiota may contribute to the development of obesity by affecting host lipid metabolism and insulin sensitivity. To investigate the effects of microbiota manipulation on ex vivo basal and β-adrenergically-stimulated lipolysis in human adipocytes, 36 obese men were randomized to amoxicillin (broad-spectrum antibiotic), vancomycin (narrow-spectrum antibiotic) or placebo treatment (7 d, 1500 mg/d). Before and after treatment, ex vivo adipose tissue lipolysis was assessed under basal conditions and during stimulation with the non-selective β-agonist isoprenaline using freshly isolated mature adipocytes. Read More

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http://dx.doi.org/10.1080/21623945.2018.1464366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152497PMC

In this issue of Adipocyte.

Authors:
Azaam M Samad

Adipocyte 2018 Jan;7(1):1-3

a Taylor & Francis Group , Philadelphia , PA.

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http://dx.doi.org/10.1080/21623945.2018.1449437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915024PMC
January 2018

What activates thermogenesis when lipid droplet lipolysis is absent in brown adipocytes?

Adipocyte 2018 Apr 5:1-5. Epub 2018 Apr 5.

a Center for Molecular and Translational Medicine, Institute for Biomedical Sciences, Georgia State University , Atlanta , GA , USA.

Cold exposure activates the sympathetic nervous system. It is generally thought that this sympathetic activation induces heat production by stimulating lipolysis of cytosolic lipid droplets (LDs) in brown adipocytes. However, this concept was not examined in vivo due to lack of appropriate animal models. Read More

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http://dx.doi.org/10.1080/21623945.2018.1453769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152517PMC
April 2018
3 Reads

Endoplasmic reticulum stress epigenetics is related to adiposity, dyslipidemia, and insulin resistance.

Adipocyte 2018 23;7(2):137-142. Epub 2018 Mar 23.

e Other members of the MENA project in alphabetical order are: Abete I, Crujeiras AB, Cuervo M, Goni L , Marti A, Martinez-Gonzalez MA, Navas-Carretero S, San-Cristobal R, Santos JL and Zulet MA.

Unresolved ER stress is involved in the onset and progression of several obesity-related metabolic disorders, including dyslipidemia and insulin resistance. Different epigenetic modifications may regulate ER stress response and consequently disease risks. These epigenetic phenomena encompass DNA and histone methylation patterns in ER stress genes and downstream signaling molecules, as well as microRNA expression. Read More

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http://dx.doi.org/10.1080/21623945.2018.1447731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152516PMC
March 2018
4 Reads

A role for FGF2 in visceral adiposity-associated mammary epithelial transformation.

Adipocyte 2018 21;7(2):113-120. Epub 2018 Mar 21.

a Department of Pharmacology and Toxicology , Michigan State University , East Lansing , MI , United States.

Obesity is a leading risk factor for post-menopausal breast cancer, and this is concerning as 40% of cancer diagnoses in 2014 were associated with overweight/obesity. Despite this epidemiological link, the underlying mechanism responsible is unknown. We recently published that visceral adipose tissue (VAT) releases FGF2 and stimulates the transformation of skin epithelial cells. Read More

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http://dx.doi.org/10.1080/21623945.2018.1445889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152512PMC

The role of polyunsaturated fatty acids (n-3 PUFAs) on the pancreatic β-cells and insulin action.

Adipocyte 2018 14;7(2):81-87. Epub 2018 Mar 14.

b Department of Clinical Chemistry , School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar , Northwest Ethiopia.

Polyunsaturated Fatty acids have multiple effects in peripheral tissues and pancreatic beta cell function. The n-3 Polyunsaturated Fatty acids prevent and reverse high-fat-diet induced adipose tissue inflammation and insulin resistance. Insulin secretion is stimulated by glucose, amino acids, and glucagon- like peptide-1 in tissue containing high levels of n-3 Polyunsaturated Fatty acids than lower level of n-3 Polyunsaturated Fatty acids. Read More

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http://dx.doi.org/10.1080/21623945.2018.1443662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152539PMC
March 2018
11 Reads
2 Citations

Fish oil as a potential activator of brown and beige fat thermogenesis.

Adipocyte 2018 9;7(2):88-95. Epub 2018 Mar 9.

a Department of Nutrition , Exercise and Sports (NEXS), Faculty of Science, University of Copenhagen , Frederiksberg , Denmark.

Numerous studies have shown that feeding rodents n-3 polyunsaturated fatty acids attenuates adiposity. Moreover, meta-analyses of human dietary intervention studies indicate that fish oil (eicosapentaenoic and docosahexaenoic acid) supplementation might reduce waist circumference. A recent line of research suggests that browning of white adipose depots and activation of uncoupled respiration in brown fat contributes to these effects. Read More

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http://dx.doi.org/10.1080/21623945.2018.1442980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152508PMC
March 2018
6 Reads

Adipocyte CD1d determines adipose inflammation and insulin resistance in obesity.

Adipocyte 2018 6;7(2):129-136. Epub 2018 Mar 6.

a Department of Biological Science , Institute of Molecular Biology & Genetics, Seoul National University , Seoul , South Korea.

Obesity-induced adipose tissue inflammation is regulated by various immune cells for innate and adaptive immunity. Among adipose tissue immune cells, it has been proposed that invariant Natural Killer T (iNKT) cells play crucial roles in anti-inflammatory responses in obesity. iNKT cells recognize 'lipid' antigens loaded on CD1d of antigen presenting cells and modulate immune responses by secreting Th1 or Th2 type cytokines depending on species of lipid antigens, antigen presenting cell types, and environmental cytokine milieu. Read More

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http://dx.doi.org/10.1080/21623945.2018.1440928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152521PMC
March 2018
3 Reads

Dysregulated lipid storage and its relationship with insulin resistance and cardiovascular risk factors in non-obese Asian patients with type 2 diabetes.

Adipocyte 2018 7;7(2):71-80. Epub 2018 Feb 7.

a Division of Endocrinology & Metabolism, Department of Medicine , Ramathibodi hospital, Mahidol university , Bangkok , Thailand.

The prevalence of non-obese type 2 diabetes in Asians is up to 50%. This review aims to summarize the role of regional fat in the development of insulin resistance and cardiovascular risk in non-obese Asian type 2 diabetes as well as the role of intra-pancreatic fat and β-cell dysfunction. The body fat content of non-obese Asian type 2 diabetic patients is not different from that of non-diabetic subjects but the proportion of intra-abdominal and intra-hepatic fat are greater. Read More

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http://dx.doi.org/10.1080/21623945.2018.1429784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152525PMC
February 2018

Mirna biogenesis pathway is differentially regulated during adipose derived stromal/stem cell differentiation.

Adipocyte 2018 7;7(2):96-105. Epub 2018 Feb 7.

f Departments of Medicine , Structural and Cellular Biology, & Surgery, Tulane University School of Medicine , New Orleans , LA , USA.

Stromal/stem cell differentiation is controlled by a vast array of regulatory mechanisms. Included within these are methods of mRNA gene regulation that occur at the level of epigenetic, transcriptional, and/or posttranscriptional modifications. Current studies that evaluate the posttranscriptional regulation of mRNA demonstrate microRNAs (miRNAs) as key mediators of stem cell differentiation through the inhibition of mRNA translation. Read More

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http://dx.doi.org/10.1080/21623945.2018.1423911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152510PMC
February 2018

Adipose tissue autophagy related gene expression is associated with glucometabolic status in human obesity.

Adipocyte 2018 Jan 5;7(1):12-19. Epub 2018 Feb 5.

a Department of Human Biology , NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+ , Maastricht , The Netherlands.

Adipose tissue autophagy (AT) is associated with human obesity and increased metabolic risk. Recent findings establish a role for autophagy in lipid metabolism. Here, we compared the expression of autophagy-related and lipolysis genes in human abdominal subcutaneous AT (SCAT) in overweight/obese subjects (n = 17) with or without impaired glucose tolerance in comparison with lean normal glucose tolerant individuals (n = 9), and investigated the association between AT autophagy and lipolysis. Read More

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http://dx.doi.org/10.1080/21623945.2017.1394537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915036PMC
January 2018
2 Reads

Emerging roles of SGLT2 inhibitors in obesity and insulin resistance: Focus on fat browning and macrophage polarization.

Adipocyte 2018 29;7(2):121-128. Epub 2018 Jan 29.

a Department of Cell Metabolism and Nutrition , Advanced Preventive Medical Sciences Research Center, Kanazawa University , Kanazawa, Ishikawa , Japan.

Obesity-associated low-grade inflammation underlies insulin resistance and associated metabolic comorbidities, such as type 2 diabetes (T2D) and nonalcoholic fatty liver disease. Excessive ectopic fat deposition in obesity causes disorders of energy homeostasis and low-grade chronic inflammation in metabolic tissues. In particular, obesity-induced recruitment and activation of adipose tissue macrophages play a key role in the pathogenesis of insulin resistance and T2D. Read More

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https://www.tandfonline.com/doi/full/10.1080/21623945.2017.1
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http://dx.doi.org/10.1080/21623945.2017.1413516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152529PMC
January 2018
8 Reads

Endothelial dysfunction occurs independently of adipose tissue inflammation and insulin resistance in ovariectomized Yucatan miniature-swine.

Adipocyte 2018 Jan 28;7(1):35-44. Epub 2017 Dec 28.

a Nutrition and Exercise Physiology , University of Missouri , Columbia , MO , United States.

In rodents, experimentally-induced ovarian hormone deficiency increases adiposity and adipose tissue (AT) inflammation, which is thought to contribute to insulin resistance and increased cardiovascular disease risk. However, whether this occurs in a translationally-relevant large animal model remains unknown. Herein, we tested the hypothesis that ovariectomy would promote visceral and perivascular AT (PVAT) inflammation, as well as subsequent insulin resistance and peripheral vascular dysfunction in female swine. Read More

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http://dx.doi.org/10.1080/21623945.2017.1405191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915048PMC
January 2018
6 Reads

Loading and firing the brown adipocyte.

Adipocyte 2018 Jan 22;7(1):4-11. Epub 2017 Dec 22.

a Department of Experimental Surgery , University Hospital Wuerzburg , Wuerzburg , Bavaria , Germany.

Brown adipose tissue (BAT) is specialized to both store and expend chemical energy making it an ideal therapeutic target for various metabolic diseases. Fatty acids derived from lipid droplets within brown adipocytes acting on mitochondrial uncoupling protein 1 (UCP1) were long thought to be essential for non-shivering thermogenesis. Here, the roles of white adipose tissue and the liver in the provision of fuel to BAT as part of a coordinated response to temperature and dietary challenges are described. Read More

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http://dx.doi.org/10.1080/21623945.2017.1405879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915016PMC
January 2018

Hypothalamic GRP78, a new target against obesity?

Adipocyte 2018 Jan 20;7(1):63-66. Epub 2017 Dec 20.

a NeurObesity Group, Department of Physiology, CIMUS , University of Santiago de Compostela, -Instituto de Investigación Sanitaria , Santiago de Compostela , Spain.

The chaperone GRP78 (glucose related protein 78), also called BiP (binding immunoglobulin protein) is a key regulator of endoplasmic reticulum (ER) stress. We recently described that over-expression of GRP78 specifically in the ventromedial nucleus of the hypothalamus (VMH) releases hypothalamic ER stress in rodent obese models leading to weight loss, reduced hepatic steatosis and improved insulin and leptin sensitivity. The action of GRP78 is mediated by a feeding-independent mechanism involving increased sympathetic tone, augmented brown adipose tissue (BAT) thermogenesis and induction browning of white adipose tissue (WAT). Read More

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http://dx.doi.org/10.1080/21623945.2017.1405878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915027PMC
January 2018

Voluntary wheel running improves adipose tissue immunometabolism in ovariectomized low-fit rats.

Adipocyte 2018 Jan 11;7(1):20-34. Epub 2017 Dec 11.

a Department of Nutrition and Exercise Physiology , University of Missouri , Columbia , MO , US.

Loss of ovarian hormones is associated with increased adiposity, white adipose tissue (WAT) inflammation, and insulin resistance (IR). Previous work demonstrated ovariectomized (OVX) rats bred for high aerobic fitness (HCR) are protected against weight gain and IR compared to rats bred for low aerobic fitness (LCR) yet wheel running prevents OVX-induced IR in LCR rats. The purpose of this study was to determine whether adipose tissue immunometabolic characteristics from female HCR and LCR rats differs before or after OVX, and whether wheel running mitigates OVX-induced adipose tissue immunometabolic changes in LCR rats. Read More

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http://dx.doi.org/10.1080/21623945.2017.1402991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915021PMC
January 2018
8 Reads

Adiponectin-leptin ratio: A promising index to estimate adipose tissue dysfunction. Relation with obesity-associated cardiometabolic risk.

Adipocyte 2018 Jan 5;7(1):57-62. Epub 2017 Dec 5.

a Metabolic Research Laboratory , Clínica Universidad de Navarra , Pamplona , Spain.

Obesity is currently the most extended metabolic disturbance worldwide favoring the development of cardiometabolic alterations such as type 2 diabetes, hypertension, and dyslipidemia. Obesity and the metabolic syndrome (MS) are characterized by an increase in circulating leptin concentrations, in parallel to a decrease in blood levels of adiponectin. Consequently, the adiponectin/leptin ratio has been suggested as a maker of adipose tissue dysfunction. Read More

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http://dx.doi.org/10.1080/21623945.2017.1402151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915018PMC
January 2018
70 Reads

Postprandial gut microbiota-driven choline metabolism links dietary cues to adipose tissue dysfunction.

Adipocyte 2018 Jan 27;7(1):49-56. Epub 2017 Nov 27.

a Department of Cellular and Molecular Medicine , Cleveland Clinic , Cleveland , OH , USA.

The human body is an integrated circuit between microbial symbionts and our Homo sapien genome, which communicate bi-directionally to maintain homeostasis within the human meta-organism. There is now strong evidence that microbes resident in the human intestine can directly contribute to the pathogenesis of obesity and associated cardiometabolic disorders. In fact, gut microbes represent a filter of our greatest environmental exposure - the foods we consume. Read More

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http://dx.doi.org/10.1080/21623945.2017.1398295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915041PMC
January 2018
5 Reads