39,175 results match your criteria Adenoviruses


A multigene typing system for human adenoviruses reveals a new genotype in a collection of Swedish clinical isolates.

PLoS One 2018 14;13(12):e0209038. Epub 2018 Dec 14.

Department of Clinical Microbiology, Virology, and Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden.

Human adenoviruses (HAdVs) are common pathogens that can cause respiratory, gastrointestinal, urogenital, and ocular infections. They are divided into seven species containing 85 genotypes. Straightforward typing systems might help epidemiological investigations. Read More

View Article
December 2018

Cloning of carrier cells infected with oncolytic adenovirus driven by midkine promoter and biosafety studies.

J Gene Med 2018 Dec 13:e3064. Epub 2018 Dec 13.

Department of Obstetrics and Gynecology, School of Medicine, Ehime University, Ehime, Japan.

Background: A549 carrier cells infected with oncolytic adenovirus can induce complete tumor reduction of subcutaneous ovarian tumors but not intraperitoneal disseminated ovarian tumors. This seems to be due to the insufficient antitumor effect of A549 carrier cells. Therefore, here we cloned a novel carrier cell with the aim of improving antitumor effects. Read More

View Article
December 2018
1 Read

Immunotherapeutic effects of recombinant adenovirus encoding interleukin 12 in experimental pulmonary tuberculosis.

Scand J Immunol 2018 Dec 13:e12743. Epub 2018 Dec 13.

Sección de Patología Experimental, Departamento de Patología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, México.

High dose of Mycobacterium tuberculosis (Mtb) strain H37Rv administered by intratracheal injection in BALB/c mice induce progressive tuberculosis (TB). In this model during the first month there is a temporal control of bacillary growth, in co-existence with macrophage activation, granuloma formation and Th-1 response. Then, bacterial proliferation recommences, accompanied by progressive pneumonia and decreasing expression of protective cytokines (IFN-γ, TNF-α). Read More

View Article
December 2018

The intestinal virome of malabsorption syndrome-affected and unaffected broilers through shotgun metagenomics.

Virus Res 2018 Dec 10. Epub 2018 Dec 10.

Laboratório de Virologia, Departamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

Malabsorption syndrome (MAS) is an economically important disease of young, commercially reared broilers, characterized by growth retardation, defective feather development and diarrheic faeces. Several viruses have been tentatively associated to such syndrome. Here, in order to examine potential associations between enteric viruses and MAS, the faecal viromes of 70 stool samples collected from diseased (n = 35) and healthy (n = 35) chickens from seven flocks were characterized and compared. Read More

View Article
December 2018

TGF-β downregulation-induced cancer cell death is finely regulated by the SAPK signaling cascade.

Exp Mol Med 2018 Dec 6;50(12):162. Epub 2018 Dec 6.

Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Korea.

Transforming growth factor (TGF)-β signaling is increasingly recognized as a key driver in cancer. In progressive cancer tissues, TGF-β promotes tumor formation, and its increased expression often correlates with cancer malignancy. In this study, we utilized adenoviruses expressing short hairpin RNAs against TGF-β1 and TGF-β2 to investigate the role of TGF-β downregulation in cancer cell death. Read More

View Article
December 2018

Complete Genome Sequence of Psittacine Adenovirus 1, Identified from Poicephalus senegalus in Italy.

Microbiol Resour Announc 2018 Sep 20;7(11). Epub 2018 Sep 20.

Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro (Padua), Italy.

Using a metagenomics approach, we were able to determine for the first time the full-genome sequence of a psittacine adenovirus 1 isolate that was recovered from the liver of a dead Senegal parrot (Poicephalus senegalus) in Italy. The results of the phylogenetic investigations revealed the existence of high genetic diversity among adenoviruses circulating in psittacine birds. Read More

View Article
September 2018
1 Read

Broadly neutralizing monoclonal antibodies against human adenovirus types 55, 14p, 7, and 11 generated with recombinant type 11 fiber knob.

Emerg Microbes Infect 2018 Dec 8;7(1):206. Epub 2018 Dec 8.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.

The re-emerging human adenovirus types HAdV7, HAdV14, and HAdV55 of species B have caused severe lower respiratory tract diseases and even deaths during recent outbreaks. However, no adenovirus vaccine or therapeutic has been approved for general use. These adenoviruses attach to host cells via the knob domain of the fiber, using human desmoglein 2 as the primary cellular receptor. Read More

View Article
December 2018

Measuring Antiviral Capacity of T Cell Responses to Adenovirus.

J Immunol 2018 Dec 7. Epub 2018 Dec 7.

Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen 72076, Tubingen, Germany;

Adenoviruses are a major cause of infectious mortality in children following allogeneic hematopoietic stem cell transplantation, with adoptive transfer of adenovirus-specific T cells being an effective therapeutic approach. We have previously shown that T cells specific for the peptide epitope LTDLGQNLLY were protective. In this study, we aimed to establish a viral dissemination assay to measure the antiviral capacity of T cells specific for this and other peptide epitopes in an infectious setting. Read More

View Article
December 2018
1 Read

Fowl adenovirus 9 ORF19, a lipase homolog, is nonessential for virus replication and is suitable for foreign gene expression.

Virus Res 2018 Dec 5;260:129-134. Epub 2018 Dec 5.

Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Canada. Electronic address:

Fowl adenovirus 9 (FAdV-9) has one of the largest genomes (45 kb) so far sequenced from all adenoviruses studied. Genus-specific genes located within the early (E) regions at the right and left ends of the viral genome have unknown functions except for ORF8 (Gam-1 gene), ORF22 and ORF1 (dUTPase gene). ORF19, located at the right end of the genome (nts 34,220-36,443), is predicted to encode a lipase protein and its homologs are also found in all FAdV genomes so far sequenced. Read More

View Article
December 2018

E4orf1: A protein for enhancing glucose uptake despite impaired proximal insulin signaling.

PLoS One 2018 6;13(12):e0208427. Epub 2018 Dec 6.

Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, United States of America.

Background: Type 2 diabetes is often linked with impaired proximal insulin signaling. Hence, a therapeutic agent that enhances cellular glucose uptake without requiring proximal insulin signaling would be desirable for improving glycemic control. The E4orf1 peptide (E4) derived from human adenovirus 36 (Ad36) promotes cellular glucose uptake in vitro and in vivo, independent of insulin. Read More

View Article
December 2018
3 Reads

KLF2 Inhibits the Migration and Invasion of Prostate Cancer Cells by Downregulating MMP2.

Am J Mens Health 2018 Dec 6:1557988318816907. Epub 2018 Dec 6.

1 Department of Urology, Peking University Third Hospital, Beijing, China.

KLF2, a member of the Kruppel-like factor (KLF) family, is thought to be a tumor suppressor in many kinds of malignant tumors. Its functions in prostate cancer (PCa) are unknown. This study aimed to explore the role of KLF2 in the migration and invasion of PCa cells. Read More

View Article
December 2018
3 Reads

Oncolytic Adenovirus Harboring Interleukin-24 Improves Chemotherapy for Advanced Prostate Cancer.

J Cancer 2018 22;9(23):4391-4397. Epub 2018 Oct 22.

Department of Urinary Surgery, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, China.

Purpose: Oncolytic adenoviruses emerge as new agents for cancer therapy. This study aimed to investigate the synergistic anti-tumor activity of oncolytic adenovirus armed with IL-24 (ZD55-IL-24) and docetaxel (DTX) on advanced prostate cancer and .

Methods: DU145 prostate cancer cells or nude mice xenografted with DU145 prostate cancer cells were treated by ZD55-IL-24 and DTX alone or in combination. Read More

View Article
October 2018
1 Read

Vomiting symptom of acute gastroenteritis estimated from epidemiological data can help predict river contamination by human pathogenic enteric viruses.

Environ Int 2018 Nov 30;123:114-123. Epub 2018 Nov 30.

INRA, UMR 1114 EMMAH, 228 route de l'Aérodrome, CS 40 509, 84914 Avignon Cedex 9, France. Electronic address:

Contamination of fresh water bodies by human enteric viruses from wastewater discharge is a well-established phenomenon. Here we propose a model of viral contamination of rivers based on acute gastroenteritis epidemiology and assess how well it can simulate in situ experimental monitoring. Noroviruses, rotaviruses, enteroviruses, adenoviruses and hepatitis A viruses were quantified by molecular methods after water concentration. Read More

View Article
November 2018
2 Reads

Notch1 provides myocardial protection by improving mitochondrial quality control.

J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.

Mitochondrial quality control is a new target for myocardial protection. Notch signaling plays an important role in heart development, maturation, and repair. However, the role of Notch in the myocardial mitochondrial quality control remains elusive. Read More

View Article
December 2018
1 Read

Oncolytic adenovirus: A tool for cancer therapy in combination with other therapeutic approaches.

J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Molecular Virology, Pasteur Institute of Iran, Tehran, Iran.

Cancer therapy using oncolytic viruses is an emerging area, in which viruses are engineered to selectively propagate in tumor tissues without affecting healthy cells. Because of the advantages that adenoviruses (Ads) have over other viruses, they are more considered. To achieve tumor selectivity, two main modifications on Ads genome have been applied: small deletions and insertion of tissue- or tumor-specific promoters. Read More

View Article
December 2018
3.839 Impact Factor

Assessment of metabolic patterns and new antitumoral treatment in osteosarcoma xenograft models by [F]FDG and sodium [F]fluoride PET.

BMC Cancer 2018 Nov 29;18(1):1193. Epub 2018 Nov 29.

Servicio de Medicina Nuclear, Clínica Universidad de Navarra, Avenida Pío XII, 36 31008, Pamplona, Spain.

Background: Osteosarcoma is the most common malignant bone tumor in children and young adults that produces aberrant osteoid. The aim of this study was to assess the utility of 2-deoxy-2-[18F-] fluoro-D-glucose ([F] FDG) and sodium [F] Fluoride (Na [F] F) PET scans in orthotopic murine models of osteosarcoma to describe the metabolic pattern of the tumors, to detect and diagnose tumors and to evaluate the efficacy of a new treatment based in oncolytic adenoviruses.

Methods: Orthotopic osteosarcoma murine models were created by the injection of 143B and 531MII cell lines. Read More

View Article
November 2018
1 Read

Antagonism of glycolysis and reductive carboxylation of glutamine potentiates activity of oncolytic adenoviruses in cancer cells.

Cancer Res 2018 Nov 28. Epub 2018 Nov 28.

Oncology, University of Oxford

Tumour cells exhibiting the Warburg effect rely on aerobic glycolysis for ATP production and have a notable addiction to anaplerotic use of glutamine for macromolecular synthesis. This strategy maximises cellular biosynthetic potential while avoiding excessive depletion of NAD+, and provides an attractive anabolic environment for viral infection. Here we evaluate infection of highly permissive and poorly permissive cancer cells with wild type adenoviruses and the oncolytic chimeric adenovirus enadenotucirev (EnAd). Read More

View Article
November 2018
1 Read

Viral Vectors for Gene Transfer.

Curr Protoc Mouse Biol 2018 Dec 28;8(4):e58. Epub 2018 Nov 28.

The Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Viral vectors are a promising tool for effective delivery of genetic material into cells. They take advantage of the natural ability of a virus to deliver a genetic payload into cells while being genetically modified such that their ability to replicate is crippled or removed. Here, an updated overview of routinely used viral vectors, including adeno-associated viruses (AAV), retroviruses/lentiviruses, and adenoviruses (Ads), is provided, as well as perspectives on their advantages and disadvantages in research and gene therapy. Read More

View Article
December 2018

Unleashing the Full Potential of Oncolytic Adenoviruses against Cancer by Applying RNA Interference: The Force Awakens.

Cells 2018 Nov 23;7(12). Epub 2018 Nov 23.

Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands.

Oncolytic virus therapy of cancer is an actively pursued field of research. Viruses that were once considered as pathogens threatening the wellbeing of humans and animals alike are with every passing decade more prominently regarded as vehicles for genetic and oncolytic therapies. Oncolytic viruses kill cancer cells, sparing healthy tissues, and provoke an anticancer immune response. Read More

View Article
November 2018

Cellular stress is a prerequisite for glucose-induced mitochondrial matrix alkalinization in pancreatic β-cells.

Mol Cell Endocrinol 2018 Nov 23. Epub 2018 Nov 23.

Mitochondrial Function, Nestlé Institute of Health Sciences, 1015, Lausanne, Switzerland. Electronic address:

Changes in mitochondrial and cytosolic pH alter the chemical gradient across the inner mitochondrial membrane. The proton chemical gradient contributes to mitochondrial ATP synthesis as well as the uptake and release of metabolites and ions from the organelle. Here mitochondrial pH and ΔpH were studied for the first time in human pancreatic β-cells. Read More

View Article
November 2018
6 Reads

Fatal bronchopneumonia caused by skunk adenovirus 1 in an African pygmy hedgehog.

J Vet Diagn Invest 2018 Nov 26:1040638718812123. Epub 2018 Nov 26.

New Hampshire Veterinary Diagnostic Laboratory, College of Life Sciences and Agriculture, University of New Hampshire, Durham, NH (Needle).

Eleven adult African pygmy hedgehogs ( Atelerix albiventris) were added to a group of 35 animals, and within 10 d, respiratory distress affected 8 of 35 resident animals in the group, but none of the introduced animals. Three animals died following onset of clinical signs. Tissues from one animal were collected and submitted for histopathology, which revealed acute necrotizing bronchopneumonia and tracheitis with intraepithelial intranuclear inclusion bodies. Read More

View Article
November 2018
4 Reads

Development of a standard protocol for quantitative polymerase chain reaction to detect adenovirus 36, which is associated with obesity.

Acta Virol 2018 ;62(4):350-359

It has been previously reported that adenovirus 36 (Ad36) infection is associated with obesity in humans and other animals. However, there is no clinically available standard protocol to detect Ad36 DNA. In this study, we developed a method for quantitative and rapid detection of Ad36 DNA. Read More

View Article
January 2018

A complete analysis of Relative Synonymous Codon Usage in HVRs1-4 region in adenovirus genome.

Authors:
J S Niczyporuk

Pol J Vet Sci 2018 Sep;21(3):459-468

Department of Poultry Diseases, National Veterinary Research Institute, Partyzantow 57, 24-100 Pulawy, Poland.

Recent outbreaks of adenovirus (FAdV) infections in poultry flocks have been determined in many countries in Europe, Asia and Australia connected with economic consequences, and loses in poultry production. To better understand the evolution and transmission of FAdV viruses, de- tailed codon usage analysis was performed for 137 recently obtained FAdV strains. A high effec- tive number of codons, and an indication the presence of low codon usage were determined. Read More

View Article
September 2018
1 Read

Fecal virome composition of migratory wild duck species.

PLoS One 2018 21;13(11):e0206970. Epub 2018 Nov 21.

Departamento de Medicina y Zootecnia de Aves, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Ciudad de México, México.

The fecal virome comprises a complex diversity of eukaryotic viruses, phages and viruses that infect the host. However, little is known about the intestinal community of viruses that is present in wild waterfowl, and the structure of this community in wild ducks has not yet been studied. The fecal virome compositions of six species of wild dabbling ducks and one species of wild diving duck were thus analyzed. Read More

View Article
November 2018
2 Reads

Cellular zinc finger protein 622 hinders human adenovirus lytic growth and limits binding of the viral pVII protein to virus DNA.

J Virol 2018 Nov 14. Epub 2018 Nov 14.

Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden

Human adenovirus (HAdV) encodes a multifunctional DNA-binding protein pVII, which is involved in virus DNA packaging and extracellular immune signaling regulation. Although the pVII is an essential viral protein, its exact role in the virus life cycle and interplay with cellular proteins have remained to a large extent unclear. We have recently identified the cellular zinc finger protein 622 (ZNF622) as a potential pVII-interacting protein. Read More

View Article
November 2018
5 Reads

Detection of Human Enteric Viruses in French Polynesian Wastewaters, Environmental Waters and Giant Clams.

Food Environ Virol 2018 Nov 13. Epub 2018 Nov 13.

Enteric, Environmental and Food Virology Laboratory, Institute of Environmental Science and Research (ESR), Kenepuru Science Centre, PO BOX 50-348, Porirua, 5240, New Zealand.

Lack of wastewater treatment efficiency causes receiving seawaters and bivalve molluscan shellfish to become contaminated, which can lead to public health issues. Six wastewater samples, five seawater samples and three batches of giant clams from Tahiti (French Polynesia) were investigated for the presence of enteric viruses, but also if present, for the diversity, infectivity and integrity of human adenoviruses (HAdV). Enteroviruses (EV), sapoviruses (SaV) and human polyomaviruses (HPyV) were detected in all wastewater samples. Read More

View Article
November 2018
1 Read

Oncolytic viruses and checkpoint inhibitors: combination therapy in clinical trials.

Clin Transl Med 2018 Nov 14;7(1):35. Epub 2018 Nov 14.

Division of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA, 91010, USA.

Advances in the understanding of cancer immunotherapy and the development of multiple checkpoint inhibitors have dramatically changed the current landscape of cancer treatment. Recent large-scale phase III trials (e.g. Read More

View Article
November 2018
4 Reads

Respiratory viruses in returning Hajj & Umrah pilgrims with acute respiratory illness in 2014-2015.

Indian J Med Res 2018 Sep;148(3):329-333

Center for Community Medicine, All India Institute of Medical Sciences, New Delhi, India.

Background & Objectives: Respiratory tract infections are common among Hajj and Umrah pilgrims which pose a public health risk of spread of respiratory infections. Influenza has been reported from Indian Hajj and Umrah returning pilgrims, but data on other respiratory pathogens are sparse in India. Here we report the presence of common respiratory viral pathogens in returning Hajj and Umrah pilgrims suffering from acute respiratory illness (ARI) in 2014-2015. Read More

View Article
September 2018
6 Reads

Effects of Triple-Mutated Hypoxia-Inducible Factor-1α on Angiogenesis and Cardiac Function Improvement in Rats with Myocardial Infarction.

Cell Physiol Biochem 2018 13;50(6):2329-2340. Epub 2018 Nov 13.

Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background/aims: The effects of hypoxia-inducible factor-1α (HIF-1α) on angiogenesis and cardiac function improvement in rats with myocardial infarction (MI) is unknown and our current study was to evaluate whether HIF-1α would be beneficial for angiogenesis and cardiac function improvement in MI rats.

Methods: A mutant of adenovirus HIF-1α (Ad-HIF-1α-Trip) was constructed by three sites mutation (Pro402, Pro564 and Asn803) in HIF-1α. The rat MI model was produced by permanent ligation of left anterior descending artery and 1×109 PFU adenovirus (Ad) vector particles of Ad-Null, Ad- HIF-1a-564/402, Ad- HIF-1a-Trip, 250ng vascular endothelial growth factor (VEGF) in 0. Read More

View Article
December 2018
2 Reads

Current practices in the management of adenovirus infection in allogeneic hematopoietic cell transplant recipients in Europe: The AdVance study.

Eur J Haematol 2018 Nov 12. Epub 2018 Nov 12.

Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.

Objective: Adenovirus (AdV) infections are potentially life-threatening for allogeneic hematopoietic cell transplant (allo-HCT) recipients. The AdVance study aimed to evaluate the incidence management and outcomes of AdV infections in European allo-HCT recipients.

Methods: As part of the study physician surveys were conducted to determine current AdV screening and treatment practices at their center. Read More

View Article
November 2018
6 Reads

Combination therapy with F5/35 fiber chimeric conditionally replicative adenoviruses expressing IL-24 enhances the antitumor effect of temozolomide against melanoma.

Cancer Med 2018 Nov 8. Epub 2018 Nov 8.

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Background: Temozolomide (TMZ) is widely used to treat melanoma; however, response rates to TMZ are low because of rapid and frequent resistance. Conditionally, replicative adenoviruses (CRAds) are an effective and promising approach. The receptor for adenovirus is coxsackie-adenovirus receptor (CAR), which is poorly expressed in most cells. Read More

View Article
November 2018
2 Reads

Adjunctive Use of Cidofovir and Intravenous Immunoglobulin to Treat Invasive Adenoviral Disease in Solid Organ Transplant Recipients.

Pharmacotherapy 2018 Dec 26;38(12):1260-1266. Epub 2018 Nov 26.

Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Background: Infections with adenoviruses (ADVs) can result in considerable mortality and morbidity in solid organ transplant (SOT) recipients. Standard therapy for ADV infections in transplant recipients is not established. At our institution, intravenous cidofovir and immunoglobulin have been used to treat disseminated or invasive ADV in SOT and hematopoietic stem cell transplant recipients. Read More

View Article
December 2018
3 Reads

Molecular epidemiology and characterization of porcine adenoviruses in pigs with diarrhea in Thailand.

Infect Genet Evol 2018 Nov 2;67:73-77. Epub 2018 Nov 2.

Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Center of Excellence in Emerging and Re-emerging Diarrheal Viruses, Chiang Mai University, Chiang Mai, Thailand. Electronic address:

Pigs have been assumed as a source of human viral infections. Surveillance of viruses in animals is essential to evaluate the risk to human and animal health and to determine economic impact. A number of studies focused mainly on well- known enteritis viruses such as porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine group A rotavirus (PRVA), however, little data is available for porcine adenovirus (PAdV). Read More

View Article
November 2018
2 Reads

Total coliforms as an indicator of human enterovirus presence in surface water across Tianjin city, China.

BMC Infect Dis 2018 Nov 1;18(1):542. Epub 2018 Nov 1.

Tianjin Institute of Environmental & Operational Medcine, Key Laboratory of Risk Assessment and Control for Environment & Food Safety, Tianjin, 300050, China.

Background: Enteric viruses in surface water pose considerable risk to morbidity in populations living around water catchments and promote outbreaks of waterborne diseases. However, due to poor understanding of the correlation between water quality and the presence of human enteric viruses, the failure to assess viral contamination through alternative viral indicators makes it difficult to control disease transmission.

Methods: We investigated the occurrence of Enteroviruses (EnVs), Rotaviruses (HRVs), Astroviruses (AstVs), Noroviruses GII (HuNoVs GII) and Adenoviruses (HAdVs) from Jinhe River over 4 years and analyzed their correlation with physicochemical and bacterial parameters in water samples. Read More

View Article
November 2018
2 Reads

Betulinic acid attenuates liver fibrosis by inducing autophagy via the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway.

J Nat Med 2018 Oct 30. Epub 2018 Oct 30.

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.

The present study was designed to investigate the effects of betulinic acid on human hepatic stellate cells in vitro and C57BL/6 mice in vivo, as well as the signaling pathways involved. In this study, we explored the effects of betulinic acid on expression of alpha smooth muscle actin and autophagy-related proteins. Betulinic acid reduced pathological damage associated with liver fibrosis, as well as serum platelet-derived growth factor and serum hydroxyproline levels. Read More

View Article
October 2018
1 Read

Carbohydrate-Based Polymer Brushes Prevent Viral Adsorption on Electrostatically Heterogeneous Interfaces.

Macromol Rapid Commun 2018 Oct 15:e1800530. Epub 2018 Oct 15.

Department of Chemical Engineering, University of Michigan, MI, 48109, USA.

Chemical heterogeneity on biomaterial surfaces can transform its interfacial properties, rendering nanoscale heterogeneity profoundly consequential during bioadhesion. To examine the role played by chemical heterogeneity in the adsorption of viruses on synthetic surfaces, a range of novel coatings is developed wherein a tunable mixture of electrostatic tethers for viral binding, and carbohydrate brushes, bearing pendant α-mannose, β-galactose, or β-glucose groups, is incorporated. The effects of binding site density, brush composition, and brush architecture on viral adsorption, with the goal of formulating design specifications for virus-resistant coatings are experimentally evaluated. Read More

View Article
October 2018
2 Reads

Effect of cold atmospheric plasma (CAP) on human adenoviruses is adenovirus type-dependent.

PLoS One 2018 26;13(10):e0202352. Epub 2018 Oct 26.

Institute of Virology and Microbiology, Centre for Biomedical Education and Research (ZBAF), School of Human Medicine, Faculty of Health, Witten/Herdecke University, Witten, Germany.

More than 70 human adenovirus types were identified divided into 7 different species (A-G). Diseases caused by human adenoviruses are type-dependent and can range from mild to severe respiratory infections, gastrointestinal infections or eye infections such as epidemic keratoconjunctivitis. Unfortunately there is no specific anti-adenovirus therapy available. Read More

View Article
October 2018
5 Reads

Human adenoviruses as waterborne index pathogens and their use for Quantitative Microbial Risk Assessment.

Sci Total Environ 2019 Feb 25;651(Pt 1):1469-1475. Epub 2018 Sep 25.

Laboratory of Hygiene and Environmental Virology, Department of Biology, University of Pisa, Via S. Zeno 37, 56127 Pisa, Italy. Electronic address:

The current microbial water quality standards are based on the monitoring of fecal indicator organisms, which are mainly bacterial indicators (i.e., Escherichia coli, intestinal enterococci), however epidemiological data indicate that viruses are important etiological agents of waterborne illnesses. Read More

View Article
February 2019
7 Reads

Rapid detection of multiple respiratory viruses based on microfluidic isothermal amplification and a real-time colorimetric method.

Lab Chip 2018 Nov;18(22):3507-3515

Institute of Disease Control and Prevention, PLA, Beijing 100071, China.

Respiratory viruses are major threats causing development of acute respiratory tract infections, which are common causes of illness and death throughout the world. Here, an integrated microsystem based on real-time colorimetry was developed for diagnosing multiple respiratory viruses. The microsystem employed magnetic beads for nucleic acid extraction and an eight-channel microfluidic array chip integrated with a loop-mediated isothermal amplification system for point-of-care screening of respiratory viruses. Read More

View Article
November 2018
1 Read

Case presentation: persistent adenovirus B3 infections associated with bronchiolitis obliterans treated with cidofovir in a child with mosaic tetrasomy 9p.

BMC Infect Dis 2018 Oct 22;18(1):529. Epub 2018 Oct 22.

Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.

Background: Adenoviruses (AdV) are non-enveloped, double-stranded DNA viruses with multiple serotypes, which cause a variety of end-organ disease in both immunocompetent and immunocompromised individuals. Some adenoviruses can become latent in the mucosa-associated lymphoid tissue (e.g. Read More

View Article
October 2018
2 Reads

Rapid Construction of a Replication-Competent Infectious Clone of Human Adenovirus Type 14 by Gibson Assembly.

Viruses 2018 10 18;10(10). Epub 2018 Oct 18.

Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China.

In 1955, Human adenovirus type 14 (HAdV-B14p) was firstly identified in a military trainee diagnosed as acute respiratory disease (ARD) in the Netherlands. Fifty years later, a genomic variant, HAdV-B14p1, re-emerged in the U.S. Read More

View Article
October 2018
1 Read

Survival of E. coli O157:H7, Salmonella Typhimurium, HAdV2 and MNV-1 in river water under dark conditions and varying storage temperatures.

Sci Total Environ 2019 Jan 22;648:1297-1304. Epub 2018 Aug 22.

Environmental Virology Laboratory, Water Pollution Research Department, National Research Centre, Dokki, Giza 12622, Egypt.

The ability of Escherichia coli O157:H7, Salmonella enterica serovar Typhimurium, Human adenovirus serotype 2 (HAdV2) and Murine Norovirus 1 (MNV-1) to survive in river water at -20, 4, room temperature (~24 °C) and 37 °C, were evaluated under dark conditions. The tested surface water was obtained from the main Nile River in the Dokki area, Giza and sterilized by autoclaving. The pathogens were inoculated separately in the autoclaved river water. Read More

View Article
January 2019

Adenoviral Gizzard Erosions in Two Belgian Broiler Farms.

Avian Dis 2018 Sep;62(3):322-325

A Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B9820 Merelbeke, Belgium.

Fowl adenovirus infections are widely prevalent in poultry. Many of the viruses can infect chickens without resulting in overt disease. Nevertheless, some fowl adenoviruses can cause important disease complexes in chickens such as inclusion body hepatitis, hydropericardium syndrome, necrotic pancreatitis, and gizzard erosion. Read More

View Article
September 2018
1 Read

Evaluation of a Novel Immunochromatographic Assay for Detection of Human Adenoviruses from Throat Swab Samples Compared with Real-time PCR.

Clin Lab 2018 Oct;64(10):1777-1781

Background: The aim of this study was to determine the sensitivity and specificity of a novel immunochromatographic assay (ICA) kit, ALSONIC® Adeno (Alfresa Pharma Co., Osaka, Japan), for the detection of human adenovirus (HAdV) from throat swab samples based on the results of real-time PCR. The incubation time required for the novel assay kit (5 minutes) is shorter than that required for other ICA kits that are available in Japan. Read More

View Article
October 2018
1 Read

Adenovirus-Associated Influenza-Like Illness among College Students, Pennsylvania, USA.

Emerg Infect Dis 2018 Nov;24(11):2117-2119

Among students with influenza-like illness at a Pennsylvania college student health center during 2016-2017, 44 (15%) of 288 with respiratory specimens tested positive for human adenovirus (HAdV). HAdV-3, -7, and -4 predominated, and types clustered temporally. HAdV infection should be considered among college students with acute respiratory illness. Read More

View Article
November 2018
6 Reads

αvβ3 Integrin Is Required for Efficient Infection of Epithelial Cells with Human Adenovirus Type 26.

J Virol 2019 Jan 10;93(1). Epub 2018 Dec 10.

Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia

Human adenoviruses (HAdVs) are being explored as vectors for gene transfer and vaccination. Human adenovirus type 26 (HAdV26), which belongs to the largest subgroup of adenoviruses, species D, has a short fiber and a so-far-unknown natural tropism. Due to its low seroprevalence, HAdV26 has been considered a promising vector for the development of vaccines. Read More

View Article
January 2019
1 Read

In vitro toxicity and efficacy of verdinexor, an exportin 1 inhibitor, on opportunistic viruses affecting immunocompromised individuals.

PLoS One 2018 17;13(10):e0200043. Epub 2018 Oct 17.

Karyopharm Therapeutics, Department of Neurofegenerative and Infectious Diseases, Newton, Massachussets, United States of America.

Infection of immunocompromised individuals with normally benign opportunistic viruses is a major health burden globally. Infections with viruses such as Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), Kaposi's sarcoma virus (KSHV), adenoviruses (AdV), BK virus (BKPyV), John Cunningham virus (JCPyV), and human papillomavirus (HPV) are significant concerns for the immunocompromised, including when these viruses exist as a co-infection with human immunodeficiency virus (HIV). These viral infections are more complicated in patients with a weakened immune system, and often manifest as malignancies resulting in significant morbidity and mortality. Read More

View Article
October 2018
2 Reads

Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies.

Viruses 2018 10 13;10(10). Epub 2018 Oct 13.

Department of Oncology and Hemato-Oncology, Center of Excellence on Neurodegenerative Diseases, University of Milan, 20122 Milan, Italy.

Oncolytic viruses (OV) are engineered to infect, replicate in and kill cancer cells. Currently, the OV therapeutic approach is mainly restricted to neoplasia amenable to direct local administration of viral particles, while the possibility of a systemic delivery of cancer-tropic viruses would extend the OV application to the treatment of metastatic neoplasia. Herein, we applied imaging to demonstrate that cancer tropism is achieved when OV are encapsulated inside extracellular vesicles (EV) administered intravenously (i. Read More

View Article
October 2018
2 Reads

Detection of coliphages and human adenoviruses in a subtropical estuarine lake.

Sci Total Environ 2019 Feb 27;649:1514-1521. Epub 2018 Aug 27.

Department of Global Environmental Health Sciences, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, United States of America. Electronic address:

Fecal indicator bacteria (FIB) have been used to assess fecal contamination in recreational water. However, enteric viruses have been shown to be more persistent in the environment and resistant to wastewater treatment than bacteria. Recently, U. Read More

View Article
February 2019
5 Reads

Ubiquitin Carboxyl Terminal Hydrolase L1 Attenuates TNF-α-Mediated Vascular Smooth Muscle Cell Migration Through Suppression of NF-κB Activation.

Int Heart J 2018 Nov 10;59(6):1409-1415. Epub 2018 Oct 10.

Tianjin Institute of Health and Environmental Medicine.

Ubiquitin carboxyl terminal hydrolase L1 (UCH-L1) is one of the deubiquitinating enzymes in the ubiquitin-proteasome system. It has been shown that UCH-L1 could markedly decrease neointima formation through suppressing vascular smooth muscle cell (VSMC) proliferation in the balloon-injured rat carotid. However, whether UCH-L1 plays roles in VSMC migration remains to be determined. Read More

View Article
November 2018
2 Reads
1.130 Impact Factor