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J Clin Med 2022 Jun 17;11(12). Epub 2022 Jun 17.

Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou 310006, China.

Although many studies show that patients with diffuse adenomyosis who underwent fertility-sparing surgery can have a successful pregnancy, their pregnancy outcomes are still controversial. The objective of this study was to determine long-term pregnancy outcomes and possible influencing factors after double-flap adenomyomectomy for patients with diffuse adenomyosis. A total of 137 patients with diffuse adenomyosis who underwent double-flap adenomyomectomy between January 2011 and December 2019 were studied, and correlations between pregnancy outcomes and clinical data, including age and junctional zone measured by magnetic resonance imaging (JZ), were analyzed. Read More

Ann Med Surg (Lond) 2022 Jun 23;78:103809. Epub 2022 May 23.

Clinic of Gynecology, Obstetrics and Gynecological Oncology, University Hospital for Gynecology, Pius-Hospital Oldenburg, Medical Campus University of Oldenburg, Germany.

Background: Adenomyosis can cause symptoms like dysmenorrhea, dyspareunia, pelvic pain and bleeding disorders and is related to subfertility and obstetrical complications. The disease is probably underestimated and underdiagnosed because of difficulties in reliable clinical examination and imaging results. The age-related prevalence of adenomyosis still remains unclear. Read More

Scanning 2022 31;2022:2366871. Epub 2022 May 31.

Ultrasonic Center, Huaibei Maternal and Child Health Hospital, Huaibei Anhui 235000, China.

In order to explore the value of color Doppler ultrasonography (TVCDS) in the diagnosis and differential diagnosis of adenomyosis. A total of 150 patients with adenomyosis admitted to a hospital from January 2020 to December 2021 were selected, taking transvaginal three-dimensional color Doppler ultrasound and abdominal ultrasound for examination, all results were compared with patient pathology or surgical results, in order to compare the accuracy of the two inspection methods. The positive predictive value of three-dimensional color Doppler ultrasonography was higher than that of abdominal ultrasonography, and the difference was statistically significant ( < 0. Read More

World J Clin Cases 2022 May;10(14):4617-4624

Department of Neurosurgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou 450000, Henan Province, China.

Background: Moyamoya disease is essentially an ischemic cerebrovascular disease. Here, we describe a case of acute recurrent cerebral infarction caused by moyamoya disease with concurrent adenomyosis which, to our knowledge, is the first in the literature. A literature review is also presented. Read More

Int J Environ Res Public Health 2022 05 11;19(10). Epub 2022 May 11.

Department of Radiological, Oncological and Pathological Sciences, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.

Uterine adenomyosis is a common benign condition defined by the presence of heterotopic endometrial glands and stroma within the myometrium. Adenomyosis is often related to infertility and other adverse pregnancy outcomes. Modern imaging techniques allow the non-invasive diagnosis of adenomyosis and, in this framework, Magnetic Resonance Imaging (MRI) has assumed a central role due to its high diagnostic accuracy in the detection of adenomyosis. Read More

Surg Neurol Int 2022 29;13:179. Epub 2022 Apr 29.

Department of Neurosurgery, Takashimadaira Central General Hospital, Itabashiku, Tokyo, Japan.

Background: Adenomyosis is a common and benign uterine disease. Acute cerebral infarction (CI) associated with adenomyosis is rarely reported and difficult to treat. We experienced successful treatment for this disease. Read More

Exp Ther Med 2022 Jun 7;23(6):374. Epub 2022 Apr 7.

State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, P.R. China.

Extracellular vesicles (EVs) carry specific proteins involved in intercellular communication. EVs with different protein contents are released into circulation in different diseases. Recent studies have identified proteins in adenomyosis (AM)-derived EVs (AMEVs) from blood as biomarkers for this disease. Read More

Sci Rep 2022 04 30;12(1):7086. Epub 2022 Apr 30.

Endometriosis Unit, ICGON, Hospital Clinic of Barcelona, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain.

Deep endometriosis (DE) occurs in 15-30% of patients with endometriosis and is associated with concomitant adenomyosis in around 25-49% of cases. There are no data about the effect of the presence of adenomyosis in terms of surgical outcomes and complications. Thus, the aim of the present study was to evaluate the impact of adenomyosis on surgical complications in women with deep endometriosis undergoing laparoscopic surgery. Read More

Radiography (Lond) 2022 Apr 27. Epub 2022 Apr 27.

Harran University, Faculty of Medicine, Department of Medical Pathology, Sanliurfa, Turkey. Electronic address:

Introduction: Apparent diffusion coefficient (ADC) values are effective in the diagnosis of different gynecological lesions.

Methods: A retrospective evaluation was made of 12 patients with uterine cervix carcinoma and 151 patients with uterine lesions, comprising endometrial cancer, endometrial polyps, carcinosarcoma, submucous myoma, adenomyosis, endometrial hyperplasia, gestational trophoblastic neoplasm (GTN), and leiomyomas. As a control group, 20 healthy volunteers with normal endometrium and normal cervix were also evaluated. Read More

J Vasc Interv Radiol 2022 05;33(5):586-592

Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Adenomyosis poses an important diagnostic and therapeutic challenge in women's health because of a variety of clinical/imaging presentations and frequent coexistence with other benign gynecologic conditions. In recent years, uterine artery embolization (UAE) for the treatment of adenomyosis has shown encouraging and favorable outcomes and long-term symptom improvement. To expand the current understanding of adenomyosis pathophysiology, imaging diagnostic criteria, and treatment outcomes, the Society of Interventional Radiology Foundation gathered a multidisciplinary Research Consensus Panel with experts from diverse backgrounds. Read More

Zhonghua Fu Chan Ke Za Zhi 2022 Apr;57(4):259-264

State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China.

To investigate the relationship between the clinical efficacy and the ablated area of endometrium in patients with internal adenomyosis treated with focused ultrasound ablation surgery (FUAS). From January 2015 to December 2018, 122 patients in Chongqing Haifu Hospital who were diagnosed as internal adenomyosis through history, clinical symptoms and enhanced magnetic resonance imaging (MRI) and treated with FUAS were enrolled in this study. According to the patient's wishes, patients were given whether to ablate the adenomyotic lesion alone or ablate the adenomyotic lesion and the endometrium that involved in adenomyotic lesions together. Read More

Ultrasound Med Biol 2022 Jul 22;48(7):1328-1335. Epub 2022 Apr 22.

Obstetrics and Gynecology Department, Croix-Rousse University Hospital of Lyon (Hospices Civils de Lyon), Lyon, France; Claude Bernard Lyon 1 University, Lyon, France.

Three-dimensional rectosonography (RSG) is a transvaginal sonography technique using rectal water contrast and 3-D acquisitions. The main points of interest of 3-D RSG could be its easy accessibility and its quick learning curve, especially with respect to rectosigmoid lesions. The objective of this prospective observational study was to assess the learning curve of 3-D RSG for the diagnosis of rectosigmoid lesions and for various other locations of deep endometriosis (DE), endometriomas and adenomyosis. Read More

Hum Reprod 2022 Apr 23. Epub 2022 Apr 23.

Faculté de Médecine, Université de Paris, Paris, France.

Study Question: What is the impact of adenomyosis on the live birth rate (LBR) in women affected by endometriosis women undergoing ART?

Summary Answer: For women undergoing ART, the presence of adenomyosis at MRI, especially T2 high-signal intensity spots within the myometrium, has a negative impact on the LBR.

What Is Known Already: Adenomyosis is a common gynecological disease. The development of imaging techniques for the diagnosis has led to several adenomyosis phenotypes being described, and fertility issues appear to vary according to the characteristics of the lesions. Read More

J Med Life 2022 Mar;15(3):397-404

Department of Obstetrics and Gynaecology of Postgraduate Education, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine.

Endometrial pathology, including hyperplastic processes in the structure of reproductive disorders, occupies one of the leading places along with inflammatory diseases of the pelvic organs, contributing to infertility in 80% of cases and irregular menstrual cycle in 40-43%. This study aims to optimize the diagnostic algorithm in patients with endometrial hyperplasia combined with chronic endometritis and determine qualitative indicators of compression sonoelastography in patients with endometrial pathology and infertility. A comprehensive clinical and laboratory examination of 90 infertile patients aged 25 to 45 years with endometrial hyperplasia combined with chronic inflammation, retention cysts, and benign ovarian tumors was carried out. Read More

J Comput Assist Tomogr 2022 May-Jun 01;46(3):379-382. Epub 2022 Apr 8.

Department of Radiology, Huashan Hospital, Fudan University, Shanghai, P.R. China.

Objective: The clinical application of magnetic resonance imaging-guided focused ultrasound (MRgFUS) surgery for treatment of symptomatic uterine fibroids is often limited because of the bowel between the abdominal wall and uterus. If bowels are in the pathway of sonication path, firstly filling the bladder, then filling the rectum, and emptying the bladder subsequently can be used to avoid them in recent research. The purpose of this study was to evaluate whether the modified bowel displacement technique (rectal filling first and then bladder filling, with or without subsequent bladder emptying) was feasible to create secure acoustic window. Read More

Reprod Med Biol 2022 Jan-Dec;21(1):e12442. Epub 2022 Feb 7.

Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases Fudan University Shanghai China.

Purpose: To investigate how the extent of fibrosis in adenomyosis lesions contributes to heavy menstrual bleeding (HMB).

Methods: We recruited 57 women with histologically confirmed adenomyosis, 29 of whom reported moderate/heavy bleeding (MHB) (menstrual blood loss (MBL) ≥20 but <100 mL) and the remaining 28, excessive MBL (EXB; ≥100 mL). Lesional stiffness was measured by transvaginal elastosonography. Read More

BMC Womens Health 2022 04 5;22(1):101. Epub 2022 Apr 5.

Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, People's Republic of China.

Background: Endometriosis is a common benign gynecological disease characterized by growing-functioning endometrial tissue outside the uterus. Extra-pelvic endometriosis, which accounts for approximately 12% of endometriosis, is more challenging to diagnose because of its distance from the pelvic organs. Halban's theory of benign metastasis indicates that endometrial cells can appear in extra-pelvic organs via lymphatic and blood vessels, but endometrial lymph node metastasis cases are still rare. Read More

Front Med (Lausanne) 2022 3;9:764523. Epub 2022 Mar 3.

Department of Ultrasound, Sheng Jing Hospital of China Medical University, Shenyang, China.

Background: Uterine cystic adenomyosis is a very rare type of adenomyosis which can be easily misdiagnosed in clinical practice. In the past, cases have been mostly treated with surgical resection of the uterine lesion.

Case Presentation: We report the case of a 25-year-old woman who presented with severe dysmenorrhea for more than 1 year. Read More

Int J Hyperthermia 2022 ;39(1):530-538

State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.

Objective: To evaluate the mid-term symptom improvement of patients with different types of adenomyosis based on magnetic resonance imaging (MRI) classification after ultrasound-guided high intensity focused ultrasound (USgHIFU) treatment.

Materials And Methods: A total of 321 patients with adenomyosis who underwent HIFU and completed 18-month follow-up were retrospectively reviewed. Based on the relationship between the adenomyotic lesion and the uterine structural components on T2-weighted imaging (T2WI), adenomyotic lesions were classified as internal, external, full thickness and intramural adenomyosis. Read More

Arch Gynecol Obstet 2022 Mar 14. Epub 2022 Mar 14.

Department of the Statistics, Apollo Institute of Medical Sciences and Research, Hyderabad, India.

Purpose: The objective of this study was to evaluate and compare the diagnostic performance of ultrasonography (USG) assessment using structured reporting with intraoperative laparoscopic assessment in deep infiltrating endometriosis (DIE) using the recent update of the #ENZIAN classification.

Methods: This was a retrospective study conducted in Tertiary Multi-disciplinary Endometriosis Care Hospital over a period of 8 months which included 50 patients who underwent a planned laparoscopic endometriosis excisional surgery after a dedicated USG assessment using International Deep Endometriosis Analysis (IDEA) protocol and #ENZIAN score (updated ENZIAN classification), between Feb 2021 and Sept 2021 at Apollo Hospitals, Hyderabad. The pre-operative USG findings were reported in a structured reporting format and intraoperative findings were classified using the standard #ENZIAN classification. Read More

Georgian Med News 2022 Feb(323):30-37

2"Evroonco" clinic, Moscow, Russia.

The aim of this work is to review current trends in the minimally invasive treatment of adenomyosis, in particular uterine artery embolization (UAE). Adenomyosis is an unsolved problem in modern gynecology, its clinical manifestations and associated infertility lead to a decrease in the quality of life of women. Advances in imaging are making it possible to diagnose adenomyosis in young women. Read More

BMC Pregnancy Childbirth 2022 Mar 8;22(1):187. Epub 2022 Mar 8.

Department of Obstetrics and Gynecology, Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Yangpu District, Shanghai, 200092, China.

Background: To examine the correlation between the occurrence of adenomyosis and the outcome of vaginal repair of cesarean section scar defects (CSDs).

Methods: A total of 278 women with CSD were enrolled in this retrospective observational cohort study at the Shanghai First Maternity & Infant Hospital between January 2013 and August 2017. Patients were divided into two groups according to preoperative magnetic resonance imaging (MRI) findings: the adenomyosis group and the non-adenomyosis group. Read More

J Clin Ultrasound 2022 Jun 7;50(5):655-659. Epub 2022 Mar 7.

Department of Obstetrics and Gynecology, Clinica Universidad de Navarra, Pamplona, Spain.

Objective: Defining the normal range for the anterior/posterior myometrial wall thickness ratio in a cohort of women without adenomyosis or any other uterine wall anomaly on ultrasound examination.

Methods: Anterior and posterior miometrial wall thickness was measured in 555 women (mean age 34.6 years old, range: 20-50 years) without any ultrasound findings of adenomiosis or other uterine pathology. Read More

Eur J Obstet Gynecol Reprod Biol 2022 Apr 24;271:223-234. Epub 2022 Feb 24.

Department of Gynaecology and Obstetrics, Catharina Hospital, Michelangelolaan 2, 5623EJ Eindhoven, Netherlands; Department of Electrical Engineering, Eindhoven University of Technology, Groene Loper 19, 5612 AP Eindhoven, Netherlands; Department of Reproductive Medicine, University Hospital Ghent, C. Heymanslaan 10, 9000 Ghent, Belgium.

Study Objectives: To assess the effect of adenomyosis, endometriosis and combined adenomyosis and endometriosis, diagnosed on MRI, on IVF/ICSI outcomes versus male subfertility controls.

Study Design: This single-centre matched retrospective cohort study was carried out at Catharina Hospital in Eindhoven, The Netherlands. The study group consisted of infertile women undergoing their first, fresh embryo transfer during IVF/ICSI, with adenomyosis only (N = 36), endometriosis only (N = 61), and combined adenomyosis and endometriosis (N = 93) based on MRI. Read More

Acta Obstet Gynecol Scand 2022 May 27;101(5):524-531. Epub 2022 Feb 27.

Department of Obstetrics and Gynecology, Skåne University Hospital, Lund University, Malmö, Sweden.

Introduction: Prevalence of endometriosis is commonly reported based on surgery findings and varies widely depending on study population and indication for surgery. Symptoms such as dysmenorrhea, pelvic pain, dyspareunia, dysuria, and dyschezia can be associated with endometriosis and adenomyosis. Transvaginal ultrasound examination is proposed to be the first-line diagnostic method, nevertheless there are no published ultrasound-based studies reporting prevalence of endometriosis and adenomyosis in symptomatic women other than those scheduled for surgery. Read More

Yonago Acta Med 2022 Feb 29;65(1):106-110. Epub 2022 Jan 29.

Department of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan.

Uterine adenomyosis is an estrogen-dependent tumor and one of the most common benign diseases in sexually mature women. The frequency of endometrial cancer associated with adenomyosis has been reported to be 18%-66%. On the other hand, endometrial cancer arising in adenomyosis (EC-AIA) is extremely rare. Read More

Taiwan J Obstet Gynecol 2022 Jan;61(1):75-79

Department of Obstetrics and Gynecology, Fibroid Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-Gu, Seoul, 06591, Republic of Korea. Electronic address:

Objective: To introduce our novel technique for myometrial defect closure after adenomyomectomy.

Materials And Methods: A retrospective cohort study. A total of 40 patients with adenomyosis who visited our clinic between October 2012 and January 2018 were recruited. Read More

J Obstet Gynaecol Res 2022 May 16;48(5):1265-1270. Epub 2022 Feb 16.

Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Uterine fibroids are known to degenerate during pregnancy, but it is unknown if similar pathologic condition occurs in adenomyosis. A 38-year-old para 1 woman exhibited uterine tenderness and a markedly elevated inflammatory response at 22 weeks of gestation. Based on magnetic resonance imaging (MRI) findings indicative of hemorrhagic components in an adenomyosis lesion, we judged these features resulted from degeneration of adenomyosis after excluding the possibility of underlying infection by amniocentesis. Read More

BMJ Case Rep 2022 Feb 7;15(2). Epub 2022 Feb 7.

Obstetrics and Gynaecology, Centro Hospitalar do Baixo Vouga, EPE, Aveiro, Portugal.

A 37-year-old woman with a previous diagnosis of Mayer-Rokitansky-Kuster-Hauser syndrome at 18 years of age was referred from a primary healthcare physician to a gynaecology appointment in our centre. She presented with a 2-year worsening pelvic pain and dyspareunia, symptoms that were previously absent and, at the time, with inadequate relief with oral analgesia. Physical examination showed absent uterine cervix and hypoplastic superior vagina. Read More

Eur J Radiol 2022 Mar 29;148:110183. Epub 2022 Jan 29.

Department of Interventional Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China. Electronic address:

Objective: The present study aimed to develop a nomogram to predict long-term outcomes of uterine artery embolisation (UAE) for treating adenomyosis.

Materials And Methods: We reviewed data of 221 patients with adenomyosis who underwent UAE between May 2016 and January 2018. Predictive factors were identified using multivariate logistic regression analysis. Read More