1,390 results match your criteria Adenoma Bronchial

Bronchiolar adenoma with unusual presentation: Two case reports.

World J Clin Cases 2022 May;10(14):4541-4549

Department of Pathology, The Affiliated Hospital of Shandong First Medical University (Liaocheng People's Hospital), Liaocheng 252000, Shandong Province, China.

Background: The clinicopathological features, immunohistochemical characteristics, and genetic mutation profile of two unusual cases of distal bronchiolar adenoma are retrospectively analyzed and the relevant literature is reviewed.

Case Summary: Case 1 was a 63-year-old female patient who had a mixed ground-glass nodule, with mild cells in morphology, visible cilia, and bilayer structures in focal areas. Immunohistochemical staining for P63 and cytokeratin (CK)5/6 revealed the lack of a continuous bilayer structure in most areas, and no mutations were found in epidermal growth factor receptor, anaplastic lymphoma kinase, ROS1, Kirsten rat sarcoma, PIK3CA, BRAF, human epidermal growth factor receptor-2 (HER2), RET, and neuroblastoma RAS genes. Read More

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Management of Bronchial Adenoma/Ciliated Muconodular Papillary Tumor with Definitive Stereotactic Body Radiation Therapy (SBRT): A Case Report.

Clin Lung Cancer 2022 Jul 29;23(5):e335-e338. Epub 2022 Apr 29.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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Metastasis of lung carcinoid in the thyroid gland after 18 years: it is never too late. A case report and review of the literature.

Pathologica 2022 Apr;114(2):164-169

Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.

Metastasis to the thyroid gland is a rare event. To date, only 11 cases of metastasis from neuroendocrine tumors (NETs) originating in the lung have been reported. We present a case of a patient in his 40s harboring two nodules in the thyroid gland that were diagnosed as well-differentiated NET (G1). Read More

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Single utility port approach in robot-assisted sleeve segmentectomy for bronchial carcinoid tumor.

Thorac Cancer 2022 05 6;13(10):1537-1540. Epub 2022 Apr 6.

Department of Thoracic Surgery, The Affiliated Hospital of Qingdao University, Shandong, China.

Bronchial carcinoid tumors are low-grade malignant and lung-sparing surgery is preferred for the removal of these tumors. We describe a surgical technique of robot-assisted sleeve segmentectomy via single utility port approach with three robotic arms. This operation was performed in an aged patient with decreased pulmonary function, whose carcinoid tumor was located at the origin of the right superior segmental bronchus. Read More

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Early differential responses elicited by BRAF in adult mouse models.

Cell Death Dis 2022 02 10;13(2):142. Epub 2022 Feb 10.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Melchor Fernández Almagro 3, Madrid, E-28029, Spain.

The BRAF gene is frequently mutated in cancer. The most common genetic mutation is a single nucleotide transition which gives rise to a constitutively active BRAF kinase (BRAF) which in turn sustains continuous cell proliferation. The study of BRAF murine models has been mainly focused on the role of BRAF in tumor development but little is known on the early molecular impact of BRAF expression in vivo. Read More

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February 2022

Glucocorticoid Receptor Antagonism Upregulates Somatostatin Receptor Subtype 2 Expression in ACTH-Producing Neuroendocrine Tumors: New Insight Based on the Selective Glucocorticoid Receptor Modulator Relacorilant.

Front Endocrinol (Lausanne) 2021 4;12:793262. Epub 2022 Jan 4.

Drug Research and Development, Corcept Therapeutics, Menlo Park, CA, United States.

Somatostatin exhibits an inhibitory effect on pituitary hormone secretion, including inhibition of growth hormone and adrenocorticotropic hormone (ACTH), and it can have antisecretory and antitumor effects on neuroendocrine tumors (NETs) that express somatostatin receptors. Although the precise mechanism remains unclear, the finding that glucocorticoids downregulate somatostatin receptor subtype 2 (SSTR2) expression has been used to explain the lack of efficacy of traditional SSTR2-targeting analogs in patients with ACTH-secreting NETs. Glucocorticoid receptor (GR) antagonism with mifepristone has been shown to reverse the glucocorticoid-induced downregulation of SSTR2; however, the effects of GR modulation on SSTR2 expression in ACTH-secreting NETs, particularly corticotroph pituitary tumors, are not well known. Read More

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Multiple bronchiolar adenomas with malignant transformation and CCNE1 mutation: a case report and literature review.

J Cardiothorac Surg 2021 Oct 18;16(1):307. Epub 2021 Oct 18.

Department of Cardiothoracic Surgery, The Third Affiliated Hospital, Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, 510630, Guangdong, People's Republic of China.

Background: Bronchiolar adenoma (BA) is a recently proposed diagnostic terminology, which is considered as the expansion of the concept of ciliated muconodular papillary tumors. BA is considered to be a benign neoplasm, but a few previous cases have been reported with the possibility of malignant transformation. Therefore, the genetic and histological nature of BA is controversial so far. Read More

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October 2021

Bronchiolar adenomas (BA) - A detailed radio-pathologic analysis of six cases and review of literature.

Ann Diagn Pathol 2021 Dec 4;55:151837. Epub 2021 Oct 4.

A.M. Rywlin, MD Department of Pathology, Mount Sinai Medical Center, Miami Beach, FL 33140, USA; Florida International University, Herbert Wertheim College of Medicine, Miami, FL 33199, USA.

Bronchiolar adenomas (BAs)/ciliated muco-nodular papillary tumors (CMPTs), are small, peripheral lung nodules arising predominantly in the elderly that follow a benign course. They can be mistaken for adenocarcinomas on frozen section. Immunohistochemistry (IHC) for basal cell markers highlights the continuous layer of basal cells underlying the tumor cells in BAs. Read More

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December 2021

Asynchronous DNA Replication of Biallelically Expressed Genes in Human Peripheral Blood Lymphocytes as a Prognostic Sign of Cancer.

Sovrem Tekhnologii Med 2021 28;13(3):33-38. Epub 2021 Jun 28.

Head of the Laboratory of Molecular and Genetic Pathology, Department of Clinical Morphology; A. Tsyb Medical Radiological Research Centre - Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 4 Korolev St., Obninsk, 249036, Russia.

was to identify and quantify lymphocytes with asynchronous replication of the and genes in cancer patients versus controls and to assess the diagnostic capabilities of this approach.

Materials And Methods: The study was carried out with peripheral blood lymphocytes probed for the and genes using the interphase fluorescence hybridization (FISH) method (Vysis, USA and Kreatech, The Netherlands). The control group included 70 people: clinically healthy donors and patients with non-oncological diseases such as gastritis, pancreatitis, chronic calculous cholecystitis, bronchial asthma, peptic ulcer disease, inguinal hernia, arthrosis, myoma, hepatitis, epilepsy, chronic prostatitis, chronic tonsillitis, and rectal adenoma. Read More

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Intranasal Iloprost Prevents Tumors in a Murine Lung Carcinogenesis Model.

Cancer Prev Res (Phila) 2022 01 23;15(1):11-16. Epub 2021 Sep 23.

Division of Pulmonary Sciences and Critical Care Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Lung cancer chemoprevention with the prostacyclin analogue iloprost is the most promising approach to date for intercepting progression of premalignant lung lesions in former smokers. Previous preclinical studies of iloprost used oral delivery, but a study modeling delivery directly to the target organ was needed. and studies have identified gene expression changes following iloprost treatment, including increased e-cadherin and and decreased and vimentin. Read More

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January 2022

Clinical significance of interventional therapeutic bronchoscopy combined with bronchial arterial embolization in the treatment of hypervascular primary airway tumors in children.

Pediatr Investig 2021 Jun 18;5(2):130-135. Epub 2021 Jun 18.

The Second Department of Respiratory Medicine Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China.

Importance: Pediatric hypervascular primary airway tumors are progressive, fatal lesions with a low incidence, and the disease is often more serious than that in adults.

Objective: To evaluate the clinical efficacy and safety of interventional therapeutic bronchoscopy combined with conservative treatment and bronchial arterial embolization in children with primary airway tumors.

Methods: We retrospectively analyzed the clinical data of four pediatric patients with hypervascular primary airway tumor between 2017 and 2019 at Beijing Children's Hospital. Read More

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Renal Papillary Necrosis Associated With Normocalcemic Primary Hyperparathyroidism.

AACE Clin Case Rep 2021 Mar-Apr;7(2):113-116. Epub 2020 Dec 28.

Department of Endocrinology, Diabetes & Metabolism, Walter Reed National Military Medical Center, Bethesda, Maryland.

Objectives: Renal papillary necrosis (RPN) occurring in primary hyperparathyroidism (PHPT) has not been reported. We present a 50-year-old woman who manifested RPN associated with hypercalciuria and normocalcemic PHPT.

Methods: The diagnosis of RPN was based on imaging studies (ultrasound and computed tomography [CT] scan). Read More

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December 2020

New types of localization methods for adrenocorticotropic hormone-dependent Cushing's syndrome.

Best Pract Res Clin Endocrinol Metab 2021 01 10;35(1):101513. Epub 2021 Mar 10.

Cambridge Endocrine Molecular Imaging Group, Metabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK. Electronic address:

The management of endogenous Cushing's syndrome (CS) typically involves two key steps: (i) confirmation of autonomous hypercortisolism and (ii) localization of the cause to guide treatment. Adrenocorticotropic hormone (ACTH)-dependent CS is most commonly due to a pituitary corticotrope tumor which may be so small as to evade detection on conventional magnetic resonance imaging (MRI). Although biochemical testing (e. Read More

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January 2021

[Clinicopathological features of bronchiolar adenoma versus mixed squamous cell and glandular papilloma: a comparative analysis].

Zhonghua Bing Li Xue Za Zhi 2021 May;50(5):458-464

Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, China.

To observe the clinicopathological features of bronchiolar adenoma (BA) and mixed squamous cell and glandular papilloma (MSGP). The relationship between them was also analyzed. Clinical data of eight patients with BA and four patients with MSGP diagnosed in China-Japan Friendship Hospital were collected from January 2018 to January 2020. Read More

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Pulmonary ossifying carcinoid - MEN in a male?

J Postgrad Med 2022 Jan-Mar;68(1):44-47

Department of Pathology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Pulmonary carcinoid tumors are considered as low-grade neoplasms, seen as centrally located endobronchial masses or as peripheral circumscribed nodules. Calcification or ossification is a known phenomenon, but presentation as large bony mass is extremely uncommon. Herein, we report a case of ossifying bronchial carcinoid along with nodular Hashimoto's thyroiditis as incidental autopsy findings in a 32-year-old patient with a prior recent excision of pituitary macroadenoma. Read More

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February 2022

Sialadenoma Papilliferum of the Bronchus: An Unrecognized Bronchial Counterpart of the Salivary Gland Tumor With Frequent BRAF V600E Mutations.

Am J Surg Pathol 2021 05;45(5):662-671

Departments of Anatomic Pathology.

Sialadenoma papilliferum (SP) is a rare benign tumor of the salivary glands, and only 3 unequivocal cases of SP arising in the bronchus have been reported. We herein describe the histomorphologic and molecular features of 4 bronchial SP cases and discuss the differential diagnosis of this entity and the relationship with its clinicopathologic mimics, in particular, glandular papilloma and mixed squamous cell and glandular papilloma (GP/MP). We encountered 2 male and 2 female patients with bronchial SP (mean: 66. Read More

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Morphological, immunohistochemical, and genetic analyses of bronchiolar adenoma and its putative variants.

J Pathol Clin Res 2021 05 5;7(3):287-300. Epub 2021 Jan 5.

Department of Pathology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, PR China.

We collected 26 cases of bronchiolar adenoma (BA) and its variants, and performed a comprehensive characterization using a combination of morphological, immunohistochemical, and genetic assessments. Of these 26, 13 were classic bilayered cases, including 10 proximal and 3 distal-type BAs. Of note, we also identified 13 cases that lacked a continuous basal cell layer. Read More

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[Clinical features and interventional bronchoscopic treatment of primary airway tumor in 8 children].

Zhonghua Er Ke Za Zhi 2021 Jan;59(1):27-32

Department No.2 of Respiratory Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

To summarize the clinical manifestations and to evaluate the feasibility of therapeutic bronchoscopy in pediatric primary airway tumors. The clinical data of 8 children presented with airway tumors in Beijing Children's Hospital from November 2016 to March 2018 were retrospectively analyzed. Descriptive analysis was used to summarize the outcome and prognosis of these children after interventional bronchoscopy. Read More

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January 2021

[A case of bronchial mucous gland adenoma: A rare diagnosis that should not be mistaken!]

Ann Pathol 2021 Apr 31;41(2):192-195. Epub 2020 Dec 31.

Service d'anatomie et cytologie pathologiques, AP-HP Cochin, 27, rue du faubourg Saint-Jacques, 75014 Paris, France.

We report the case of a 32-year-old man, who was admitted for a recurrent pneumopathy. The thoracic computed tomography revealed a small well-circumscribed lesion of the lower right lobe of the lung. Microscopic examination from the biopsy material of the endoscopy concluded a mucoepidermoid carcinoma. Read More

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Rehabilitation Therapy for Vocal Fold Paralysis Caused by Lung Cancer: A Case Report.

Phys Ther 2020 12;100(12):2198-2204

Rehabilitation Department, Daping Hospital, Army Medical University, Chongqing 400042 China.

Objective: Unilateral vocal fold paralysis (UVFP) can be caused by iatrogenic injury or tumor-induced damage to the recurrent laryngeal nerve. Studies of comprehensive rehabilitation therapies for patients suffering from severe UVFP are limited. The purpose of this case report is to describe an improvement in complete aphonia after comprehensive rehabilitation therapies in a patient with severe UVFP due to a lung tumor. Read More

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December 2020

A bronchial mucous gland adenoma harboring GNAS R201C mutation.

Diagn Cytopathol 2021 Jun 25;49(6):E203-E206. Epub 2020 Nov 25.

Department of Surgical Pathology, Teikyo University, Chiba Medical Center, Ichihara, Japan.

We present a case of bronchial mucous gland adenoma (MGA) and discuss the results of its cytomorphological and cytogenetic examination serving as a basis for the differential diagnosis. To our best knowledge, this is a first report that demonstrate a GNAS gene (R201C) mutation in mucous gland adenoma, which may play an important role in MGA tumorigenesis, as is the case in other mucinous-type epithelial neoplasms of various organs. Read More

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A case report of bronchial pleomorphic adenoma in a child in China.

BMC Pulm Med 2020 Nov 11;20(1):295. Epub 2020 Nov 11.

Department of Respiratory Medicine, Children's Hospital of Shanghai, Shanghai Jiao Tong University, Shanghai, China.

Background: Paediatric cases of pleomorphic adenoma of the bronchus are rare in clinical practice, despite pleomorphic adenoma being the most common histological form of salivary gland neoplasm. To date, no such cases have been reported in China.

Case Presentation: We report a case of pleomorphic adenoma of the bronchus in a 10-year-old child with no obvious positive signs on examination. Read More

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November 2020

[Bronchiolar adenoma: report of a case].

Zhonghua Bing Li Xue Za Zhi 2020 Sep;49(9):946-948

Department of Pathology, Affiliated Hospital of Jining Medical College, Shandong Province, Jining 272000, China.

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September 2020

Bronchiolar adenoma with diffuse pulmonary nodules: a extremely rare case report and review of literature.

BMC Pulm Med 2020 Jul 14;20(1):192. Epub 2020 Jul 14.

Department of Pathology, Tianjin Fifth Central Hospital, 41 Zhejiang Road, Tanggu District, Tianjin, 300450, China.

Background: Bronchiolar adenoma(BA) is a recently recognized, rare tumor of the bronchioles. It can be divided into proximal and distal types according to the proportion of mucinous and ciliated cells on the luminal surface. BA is often misdiagnosed because it has similar ultrasonographic, gross and histological presentations as other diseases. Read More

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Well-differentiated fetal adenocarcinoma of the lung: positron emission tomography features and diagnostic difficulties in frozen section analysis-a case report.

Surg Case Rep 2020 Jun 29;6(1):152. Epub 2020 Jun 29.

Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Background: Well-differentiated fetal adenocarcinoma (WDFA) of the lung is a rare disease that resembles fetal lung tubules. Most of previous reports concerning WDFA have focused on histological features, while there are few reports describing radiological features. In addition, there are no reports evaluating the difficulty of intraoperative diagnosis of WDFA with frozen section. Read More

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A Case of Localized Malignant Peritoneal Mesothelioma With Lung Cancer Detected by 18F-FDG PET/CT.

Clin Nucl Med 2020 Oct;45(10):795-797

From the Department of Radiology.

A 62-year-old woman was referred for cough and lower abdominal pain. F-FDG PET/CT showed strong uptake not only in the left lung mass and hilar and mediastinal lymph nodes, but also a huge lower abdominal mass. All lesions were initially thought to be multiple metastases because bronchial biopsy of the lung mass showed poorly differentiated adenocarcinoma. Read More

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October 2020

Persistent hyperparathyroidism due to mediastinal parathyroid adenoma treated with selective arterial embolization with embosphere: first case in the literature.

G Yuce N C Seyrek

Osteoporos Int 2020 Nov 5;31(11):2259-2262. Epub 2020 Jun 5.

Endocrinology and Metabolism Department, Ankara Yildirim Beyazit University, Ankara, Turkey.

Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia in the clinical setting and affects 0.3% of the population. Parathyroidectomy is the only definitive cure. Read More

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November 2020

Mechanism of miR-222 and miR-126 regulation and its role in asbestos-induced malignancy.

Int J Biochem Cell Biol 2020 04 4;121:105700. Epub 2020 Feb 4.

Department of Clinical and Molecular Sciences, Section of Experimental and Occupational Medicine, Polytechnic University of Marche, Via Tronto 10/A, 60020, Ancona, Italy. Electronic address:

MiR-222 and miR-126 are associated with asbestos exposure and the ensuing malignancy, but the mechanism(s) of their regulation remain unclear. We evaluated the mechanism by which asbestos regulates miR-222 and miR-126 expression in the context of cancer etiology. An 'in vitro' model of carcinogen-induced cell transformation was used based on exposing bronchial epithelium BEAS-2B cells to three different carcinogens including asbestos. Read More

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Histologic characteristics and prognosis of lung mixed squamous cell and glandular papilloma: six case reports.

Int J Clin Exp Pathol 2019 1;12(9):3542-3548. Epub 2019 Sep 1.

Department of Clinical Laboratory, The Fourth Hospital of Hebei Medical University Shijiazhuang, China.

Lung mixed squamous cell and glandular papilloma (LMSCGP) has no clear signs, clinical symptoms, or imaging features; thus, its diagnosis primarily relies on post-resection histology and immunohistochemistry. Therefore, in this work six case reports are described to review the clinicopathologic characteristics, diagnosis, treatment, and prognosis. Here, we report the clinical symptoms, imaging features, pathologic characteristics, and follow-up data of six LMSCGP patients. Read More

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September 2019

La néoplasie endocrinienne multiple de type 1 : mise au point après le congrès de l’ENETS 2019: Multiple Endocrine Neoplasia Type 1: Development after the ENETS 2019 Congress.

Ann Endocrinol (Paris) 2019 Sep;80 Suppl 1:S19-S28

Service endocrinologie et maladies métaboliques, pôle cardio-vasculaire et métabolique, CHU Larrey-Rangueil, Toulouse, France.

Multiple Endocrine Neoplasia Type 1 (NEM1) is related to mutations of the menin gene. It is an autosomal dominant disease. Its prevalence is about 1/30 000 with a hugh penetrance. Read More

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September 2019