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    Association between prior antibiotic therapy and subsequent risk of community-acquired infections: a systematic review.
    J Antimicrob Chemother 2017 Nov 14. Epub 2017 Nov 14.
    Department of Primary Care and Public Health Sciences, King's College London, Addison House, Guy's Campus, London SE1 1UL, UK.
    Background: Antibiotic use can have negative unintended consequences including disruption of the human microbiota, which is thought to protect against pathogen overgrowth. We conducted a systematic review to assess whether there is an association between exposure to antibiotics and subsequent risk of community-acquired infections.

    Methods: We searched MEDLINE, EMBASE and Web of Science for studies published before 30 June 2017, examining the association between antibiotic use and subsequent community-acquired infection. Read More

    Sarcopenia in Peripheral Arterial Disease: Prevalence and Impact on Functional Status.
    Arch Phys Med Rehabil 2017 Nov 11. Epub 2017 Nov 11.
    Department of Veterans Affairs and Veterans Affairs Medical Center Baltimore, Geriatric Research, Education and Clinical Center (GRECC), Baltimore, MD, USA; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
    Objectives: To determine the prevalence of sarcopenia in older men with peripheral arterial disease (PAD) and to compare to a subset of the group to age, race, sex, and body mass index (BMI)-matched non-PAD control counterparts. We also sought to compare the functional status of those with PAD with and without sarcopenia.

    Design: Cohort study. Read More

    Clues for early detection of autoimmune Addison's disease - myths and realities.
    J Intern Med 2017 Nov 3. Epub 2017 Nov 3.
    Department of Clinical Medicine, University of Bergen, Bergen, Norway.
    Background: Early detection of autoimmune Addison's disease (AAD) is important as delay in diagnosis may result in a life-threatening adrenal crisis and death. The classical clinical picture of untreated AAD is well-described, but methodical investigations are scarce.

    Objective: Perform a retrospective audit of patient records with the aim of identifying biochemical markers for early diagnosis of AAD. Read More

    HIV Case Management Support Service Is Associated with Improved CD4 Counts of Patients Receiving Care at the Antiretroviral Clinic of Pantang Hospital, Ghana.
    AIDS Res Treat 2017 20;2017:4697473. Epub 2017 Sep 20.
    Division of Epidemiology & Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
    Background: Factors associated with individual patient-level management of HIV have received minimal attention in sub-Saharan Africa. This study determined the association between support services and cluster of differentiation 4 (CD4) counts among HIV patients attending ART clinic in Ghana.

    Methodology: This was a cross-sectional study involving adults with HIV recruited between 1 August 2014 and 31 January 2015. Read More

    Cytokine autoantibody screening in the Swedish Addison Register identifies patients with undiagnosed APS1.
    J Clin Endocrinol Metab 2017 Oct 20. Epub 2017 Oct 20.
    Center for Molecular Medicine, Dept. of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.
    Context: Autoimmune polyendocrine syndrome type 1 (APS1) is a monogenic disorder that features autoimmune Addison's disease as a major component. Although APS1 accounts for only a small fraction of all Addison's disease cases, it is vital with an early identification of these individuals in order to prevent potentially lethal complications of APS1.

    Objective: To determine whether available serological and genetic markers are valuable screening tools for the identification of APS1 among patients diagnosed with Addison's disease. Read More

    A case of primary adrenal failure in the emergency department.
    Am J Emerg Med 2017 Oct 16. Epub 2017 Oct 16.
    Manchester Memorial Hospital, Department of Emergency Medicine, Manchester, CT, USA. Electronic address:
    Background: Primary adrenal failure is considered to be an extremely rare disease presenting in the ED, with an incidence reported to be as low as 50 cases per 1,000,000 persons (Klauer, 2017). I would like to present a case of a young man who presented to the ED, with what I suspected to be this rare entity.

    Case Report: A 26year old otherwise healthy male presented to our ED with complaints of weakness, nausea, vomiting, and hiccups of 1. Read More

    Cardiac tamponade in a patient with autoimmune polyglandular syndrome type 2.
    Endocrinol Diabetes Metab Case Rep 2017 13;2017. Epub 2017 Oct 13.
    1st Department of Cardiology, Hellenic Red Cross Hospital, Athens, Greece.
    We describe a case of a 40-year-old woman who was admitted to the intensive care unit with a rapid onset of dyspnea and orthopnea. She presented progressive weakness, weight loss and secondary amenorrhea during last year, while intermittent fever was present for the last two months. Initial biochemical evaluation showed anemia, hyponatremia and increased C-reactive protein levels. Read More

    A novel data-driven workflow combining literature and electronic health records to estimate comorbidities burden for a specific disease: a case study on autoimmune comorbidities in patients with celiac disease.
    BMC Med Inform Decis Mak 2017 Sep 29;17(1):140. Epub 2017 Sep 29.
    Georges Pompidou European Hospital (HEGP), AP-HP, Paris, France.
    Background: Data collected in EHRs have been widely used to identifying specific conditions; however there is still a need for methods to define comorbidities and sources to identify comorbidities burden. We propose an approach to assess comorbidities burden for a specific disease using the literature and EHR data sources in the case of autoimmune diseases in celiac disease (CD).

    Methods: We generated a restricted set of comorbidities using the literature (via the MeSH® co-occurrence file). Read More

    Human Papillomavirus Status and the Risk of Cerebrovascular Events Following Radiation Therapy for Head and Neck Cancer.
    J Am Heart Assoc 2017 Aug 30;6(9). Epub 2017 Aug 30.
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Background: Radiation therapy (RT) is a standard treatment for head and neck cancer; however, it is associated with inflammation, accelerated atherosclerosis, and cerebrovascular events (CVEs; stroke or transient ischemic attack). Human papillomavirus (HPV) is found in nearly half of head and neck cancers and is associated with inflammation and atherosclerosis. Whether HPV confers an increased risk of CVEs after RT is unknown. Read More

    Physical performance and movement-evoked pain profiles in community-dwelling individuals at risk for knee osteoarthritis.
    Exp Gerontol 2017 Nov 24;98:186-191. Epub 2017 Aug 24.
    Pain Research & Intervention Center of Excellence, University of Florida, USA; Institute on Aging, University of Florida, USA; Department of Community Dentistry and Behavioral Science, College of Dentistry, University of Florida, USA.
    Background: Knee pain associated with osteoarthritis is a significant contributor to decreased physical function. Recent evidence supports the inter-individual heterogeneity associated with knee pain presentation, but whether there is similar heterogeneity in physical performance among these individuals has not been previously examined. The aim of the present study was to characterize the variability in physical performance profiles and the pain evoked by their performance (i. Read More

    Clinical relevance of the modified physical performance test versus the short physical performance battery for detecting mobility impairments in older men with peripheral arterial disease.
    Disabil Rehabil 2017 Aug 23:1-5. Epub 2017 Aug 23.
    a Department of Veterans Affairs and Veterans Affairs Medical Center Baltimore, Geriatric Research , Education and Clinical Center (GRECC) , Baltimore , MD , USA.
    Purpose: The study is to compare the Modified Physical Performance Test (MPPT) and Short Physical Performance Battery (SPPB) as metrics of mobility and function in older men with peripheral arterial disease (PAD).

    Materials And Methods: A total of 51 men (55-87 years) with PAD underwent functional testing including the SPPB, MPPT, Walking Impairment Questionnaire (WIQ), stair ascent, and 6-min walk distance. Individuals were grouped according to SPPB and MPPT scores as not limited on either, limited only on the MPPT, or limited on both. Read More

    Natural history of autoimmune primary ovarian insufficiency in patients with Addison's disease: from normal ovarian function to overt ovarian dysfunction.
    Eur J Endocrinol 2017 Oct 21;177(4):329-337. Epub 2017 Jul 21.
    Diabetes UnitDepartment of Medical, Surgical, Neurological, Metabolic Sciences and Aging, University of Campania 'L. Vanvitelli', Naples, Italy.
    Context: Women with autoimmune Addison's disease with normal ovulatory cycles but positive for steroid cell antibodies (StCA) have been considered at risk of premature ovarian insufficiency (POI).

    Design: Thirty-three women younger than 40 years, with subclinical-clinical autoimmune Addison's disease but with normally ovulatory menses, were followed up for 10 years to evaluate the long-term time-related variations of StCA, ovarian function and follicular reserve. All patients and 27 control women were investigated at the start and every year for the presence and titre of StCA (by indirect immunofluorescence), serum concentrations of anti-Mullerian hormone (AMH) and ovarian function at four consecutive menses every year. Read More

    Addison's Disease Caused by Tuberculosis with Atypical Hyperpigmentation and Active Pulmonary Tuberculosis.
    Intern Med 2017 15;56(14):1843-1847. Epub 2017 Jul 15.
    Department of Medical Education and General Practice, Osaka City University, Graduate School of Medicine, Japan.
    We herein report a case of Addison's disease caused by tuberculosis characterized by atypical hyperpigmentation, noted as exacerbation of the pigmentation of freckles and the occurrence of new freckles, that was diagnosed in the presence of active pulmonary tuberculosis. The clinical condition of the patient was markedly ameliorated by the administration of hydrocortisone and anti-tuberculosis agents. When exacerbation of the pigmentation of the freckles and/or the occurrence of new freckles are noted, Addison's disease should be considered as part of the differential diagnosis. Read More

    Contrast-Enhanced Ultrasound Reveals Exercise-Induced Perfusion Deficits in Claudicants.
    J Vasc Endovasc Surg 2017 6;2(1). Epub 2017 Mar 6.
    Department of Surgery, Division of Vascular Surgery, Baltimore VA Medical Center, University of Maryland School of Medicine, Baltimore, USA.
    Background: Contrast-Enhanced Ultrasonography (CEUS) is an imaging modality allowing perfusion quantification in targeted regions of interest of the lower extremity that has not been possible with color-flow imaging or with measurement of ankle brachial indices. We developed a protocol to quantify lower extremity muscle perfusion impairment in PAD patients in response to exercise.

    Methods And Findings: Thirteen patients with Rutherford Class I-III Peripheral Arterial Disease (PAD) and no prior revascularization procedures were recruited from the Baltimore Veterans Affairs Medical Center and compared with eight control patients without PAD. Read More

    Adrenal crisis in metastatic breast cancer.
    BMJ Case Rep 2017 Jul 6;2017. Epub 2017 Jul 6.
    Interne I: Internistische Onkologie, Hämatologie u. Gastroenterologie, Ordensklinikum Linz Krankenhaus d. Barmherzigen Schwestern Linz Betriebs GmbH, Linz, Austria.
    A female patient with oestrogen receptor-positive and human epidermal growth factor receptor 2 (HER2)-positive invasive lobular breast cancer presented with progressive disease on CT scan. Some days after initiation of antineoplastic chemotherapy and anti-HER2 targeted antibody therapy, the patient presented with profuse diarrhoea, neutropaenia, nausea and weakness. Although Clostridium difficile was rapidly tackled as a causative agent of gastrointestinal complaints, clinical situation did not markedly improve despite proper antimicrobial treatment. Read More

    Factors Affecting Dietary Practices in a Mississippi African American Community.
    Int J Environ Res Public Health 2017 Jul 3;14(7). Epub 2017 Jul 3.
    Center of Excellence in Minority Health and Health Disparities, School of Public Health, Jackson State University, 350 West Woodrow Wilson Drive, Suite, 2900B, Jackson, MS 39213, USA.
    This study examined the practices, personal motivation, and barriers of African American communities in Mississippi regarding their dietary practices. We selected the Metro Jackson Area comprised of Hinds, Madison and Rankin Counties because it is a combination of urban and rural communities. The sample consisted of 70 participants from seven sites. Read More

    The Serological and Biochemical Markers of Adrenal Cortex and Endocrine Pancreas Dysfunction in Patients with Hashimoto's Thyroiditis: A Hospital-based Pilot Study.
    Indian J Endocrinol Metab 2017 Jul-Aug;21(4):540-544
    Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
    Background: The prevalence of both islet cell and adrenal autoimmunity among Asian Indian hypothyroidism patients with Hashimoto's thyroiditis (HT) is lacking in literature.

    Objectives: The objective of this study was to assess the proportion of Addison's disease (AD) and type 1 diabetes mellitus (T1DM) in patients with HT.

    Materials And Methods: The patients with hypothyroidism due to HT were included in this study over 2 years. Read More

    Multifocal oral melanoacanthoma associated with Addison's disease and hyperthyroidism: a case report.
    Arch Endocrinol Metab 2017 Jul-Aug;61(4):403-407. Epub 2017 Jun 26.
    Divisão de Patologia Oral, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brasil.
    Oral melanoacanthoma is a mucocutaneous, pigmented, rare, benign, and probably reactive lesion. This paper reports for the first time in the literature a case of multifocal oral melanoacanthoma in a patient diagnosed with Addison's disease and concomitant Graves' disease with hyperthyroidism. The patient presented with oral pigmented lesions, which were hypothesized to be mucosal pigmentation associated with Addison's disease. Read More

    The Key to Adrenal Insufficiency Education: Repetition, Repetition, Repetition.
    Pediatr Endocrinol Rev 2017 Jun;14 Suppl 2(Suppl 2):448-453
    Organic Acid Research Section (OARS) of the Medical Genomics and Metabolic Genetics Branch (MGMGB) National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
    Described more than 150 years ago by Thomas Addison, adrenal gland dysfunction, while treatable, remains a clinically significant and potentially fatal disease. Vague and non-specific symptomatology can delay diagnosis of adrenal insufficiency and lead to adrenal crisis. Affected individuals may delay self-management due to knowledge deficits or lack of required therapies. Read More

    Sex differences in vascular stiffness and relationship to the risk of renal functional decline in patients with type 2 diabetes.
    Diab Vasc Dis Res 2017 Jul 9;14(4):304-309. Epub 2017 Mar 9.
    3 Population Health Research Institute, St George's, University of London, London, UK.
    Background: Recent data suggest that the higher risk of end-stage renal disease in women compared with men is associated with waist circumference. We investigated whether vascular stiffness which is linked to visceral fat accumulation is gender specific and associated with a loss in renal function.

    Methods: We studied 166 patients with type 2 diabetes at high risk of progressive renal disease. Read More

    Histopathologic Findings of Cutaneous Hyperpigmentation in Addison Disease and Immunostain of the Melanocytic Population.
    Am J Dermatopathol 2017 May 31. Epub 2017 May 31.
    *Department of Cellular Pathology, CellCOM-SB Group, Servicio de Anatomía Patologica, Hospital El Bierzo, Cellular Pathology, Ponferrada, Spain; †Department of CellCOM-SB Group, Biomedical Investigation Institute of A Coruña, CellCOM-SB Group, A Coruña, Spain; ‡Department of Cellular Pathology, Hospital de la Reina, Cellular Pathology, Ponferrada, Spain; and §Department of Dermatology, Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente, Los Angeles, CA.
    The histopathological features of cutaneous hyperpigmentation in Addison disease have very occasionally been reported, and they include acanthosis, hyperkeratosis, focal parakeratosis, spongiosis, superficial perivascular lymphocytic infiltrate, basal melanin hyperpigmentation, and superficial dermal melanophages. We present a study on 2 biopsies from the arm and the thigh in a 77-year-old woman with a long clinical history of Addison disease as well as senile purpura and alopecia of female pattern. The patient presented diffuse hyperpigmentation of the skin, more pronounced on her face, and left upper forehead. Read More

    Premature ovarian failure could be an alarming sign of polyglandular autoimmune dysfunction.
    Endocr Regul 2017 Apr;51(2):114-116
    .
    A 31-year-old lady, diagnosed to have premature ovarian failure in the gynecology clinic, was referred for endocrine assessment because of an abnormal thyroid function test. Clinical examination revealed hypotension, and fungal skin infection under her atrophic breasts. Thyroid stimulating hormone (TSH) level was very high. Read More

    Efficacy and Safety of Degludec versus Glargine in Type 2 Diabetes.
    N Engl J Med 2017 08 12;377(8):723-732. Epub 2017 Jun 12.
    From the Research Medical Center, Kansas City, MO (S.P.M.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto (B.Z.); Imperial Clinical Trials Unit, Imperial College London, London (N.R.P.); University of Washington, Seattle (S.S.E.); Medical University of Graz, Graz, Austria (T.R.P.); Florida Hospital Translational Research Institute for Metabolism and Diabetes and Sanford Burnham Prebys Medical Discovery Institute, Orlando (R.E.P.); Novo Nordisk, Søborg, Denmark (P.-M.H., M.L., K.B.-F., A.M., S.S., K.K.); and University of North Carolina School of Medicine, Chapel Hill (J.B.B.).
    Background: Degludec is an ultralong-acting, once-daily basal insulin that is approved for use in adults, adolescents, and children with diabetes. Previous open-label studies have shown lower day-to-day variability in the glucose-lowering effect and lower rates of hypoglycemia among patients who received degludec than among those who received basal insulin glargine. However, data are lacking on the cardiovascular safety of degludec. Read More

    Amyloidosis Cutis Dyschromica, a Rare Cause of Hyperpigmentation: A New Case and Literature Review.
    Pediatrics 2017 May;139(5)
    Department of General Pediatrics and Division of Pediatric Endocrinology and Diabetes, University Children's Hospital Heidelberg, Heidelberg, Germany; and.
    Amyloidosis cutis dyschromica is a rare form of primary cutaneous amyloidosis without systemic involvement and characterized by asymptomatic, progressive hyper- and hypopigmentation. We present the first case of a patient with amyloidosis cutis dyschromica diagnosed previously elsewhere as having Addison disease with generalized hyperpigmentation of the skin. This case suggests that in patients presenting with asymptomatic cutaneous dyschromia a skin biopsy for histopathological examination should be considered. Read More

    Genetic defects in pediatric-onset adrenal insufficiency in Japan.
    Eur J Endocrinol 2017 Aug 25;177(2):187-194. Epub 2017 May 25.
    Department of PediatricsKeio University School of Medicine, Tokyo, Japan
    Context: Most patients with pediatric-onset primary adrenal insufficiency (PAI), such as 21-hydroxylase deficiency, can be diagnosed by measuring the urine or serum levels of steroid metabolites. However, the etiology is often difficult to determine in a subset of patients lacking characteristic biochemical findings.

    Objective: To assess the frequency of genetic defects in Japanese children with biochemically uncharacterized PAI and characterize the phenotypes of mutation-carrying patients. Read More

    Disseminated Cryptococcosis with Adrenal Insufficiency and Meningitis in an Immunocompetent Individual.
    Intern Med 2017 15;56(10):1259-1264. Epub 2017 May 15.
    Department of Internal Medicine, Japan Self Defense Forces Central Hospital, Japan.
    We present a case of cryptococcosis with adrenal insufficiency and meningitis in a healthy host without any risk factors. Antifungal therapy did not reduce the cryptococcal antigen titers of the cerebrospinal fluid and serum or the bilateral adrenal gland enlargement. It was suggested that the adrenal glands were the focus of persistent fungemia. Read More

    Evolution of the "fourth stage" of epidemiologic transition in people aged 80 years and over: population-based cohort study using electronic health records.
    Popul Health Metr 2017 May 12;15(1):18. Epub 2017 May 12.
    Department of Primary Care and Public Health Sciences, King's College London, 3rd Floor Addison House, Guy's Campus, London, SE1 1UL, UK.
    Background: In the "fourth stage" of epidemiological transition, the distribution of non-communicable diseases is expected to shift to more advanced ages, but age-specific changes beyond 80 years of age have not been reported.

    Methods: This study aimed to evaluate demographic and health transitions in a population aged 80 years and over in the United Kingdom from 1990 to 2014, using primary care electronic health records. Epidemiological analysis of chronic morbidities and age-related impairments included a cohort of 299,495 participants, with stratified sampling by five-year age group up to 100 years and over. Read More

    Eruptive melanocytic nevi during azathioprine therapy for antisynthetase syndrome.
    Cutis 2017 Apr;99(4):268-270
    Department of Dermatology, University of Maryland Medical Center, Baltimore, USA.
    Eruptive melanocytic nevi (EMN) are rare multiple benign melanocytic nevi that develop within a few months. The phenomenon has been associated with a variety of dermatologic and systemic conditions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, epidermolysis bullosa, Addison disease, human immunodeficiency virus infection, and internal malignancy, among others. It also is commonly attributed to medications, particularly immunosuppressive and chemotherapeutic agents. Read More

    Impact of Coronary Calcification on Clinical Management in Patients With Acute Chest Pain.
    Circ Cardiovasc Imaging 2017 May;10(5)
    From the Cardiac MR PET CT Program (D.O.B., T.M., F.B., T.R.H., S.J., D.A., M.T.L., U.H., M.F.), Department of Radiology (D.O.B., T.M., T.R.H., S.J., D.A., M.T.L., U.H., M.F.), and Department of Emergency Medicine (J.T.N.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Cardiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Germany (D.O.B.); School of Business Studies, Stralsund University of Applied Sciences, Germany (T.M.); Department of Diagnostic and Interventional Radiology, University of Tuebingen, Germany (F.B.); Division of Cardiology and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Department of Radiology, Weill Cornell Medicine, New York City (Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (P.K.W.); Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA (J.E.H., A.M.C.); Department of Emergency Medicine, Wake Forest School of Medicine, Winston-Salem, NC (C.M.); Penn State Heart and Vascular Institute, Hershey, PA (H.S.); Perelman School of Medicine of the University of Pennsylvania, Philadelphia (H.L.); and Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.).
    Background: Coronary artery calcification (CAC) may impair diagnostic assessment of coronary computed tomography angiography (CTA). We determined whether CAC affects efficiency of coronary CTA in patients with suspected acute coronary syndrome (ACS).

    Methods And Results: This is a pooled analysis of ACRIN-PA (American College of Radiology Imaging Network-Pennsylvania) 4005 and the ROMICAT-II trial (Rule Out Myocardial Infarction/Ischemia Using Computer Assisted Tomography) comparing an initial coronary CTA strategy to standard of care in acute chest pain patients. Read More

    MECHANISMS IN ENDOCRINOLOGY: Update on pathogenesis of primary adrenal insufficiency: beyond steroid enzyme deficiency and autoimmune adrenal destruction.
    Eur J Endocrinol 2017 Sep 27;177(3):R99-R111. Epub 2017 Apr 27.
    Departments of Pediatrics and Clinical ResearchBern University Children's Hospital Inselspital, University of Bern, Bern, Switzerland
    Primary adrenal insufficiency (PAI) is potentially life threatening, but rare. In children, genetic defects prevail whereas adults suffer more often from acquired forms of PAI. The spectrum of genetic defects has increased in recent years with the use of next-generation sequencing methods and now has reached far beyond genetic defects in all known enzymes of adrenal steroidogenesis. Read More

    A Case of Autoimmune Polyglandular Syndrome .ype 2 Associated with Atypical Form of Scleromyxedema.
    Ethiop J Health Sci 2016 Sep;26(5):503-507
    Department of Clinical Immunology, Allergology and Endocrinology, Donetsk National Medical University, Ukraine.
    Background: Autoimmune polyglandular syndrome type 2 represents an uncommon endocrine disorder composed by Addison's disease with autoimmune thyroid disease (Schmidt's syndrome) and/or type 1 diabetes mellitus. Scleromyxedema is a rare progressive cutaneous mucinosis usually associated with systemic involvement and paraproteinemia. To the best of our knowledge, there is no case report of Schmidt's syndrome associated with scleromyxedema. Read More

    Endocrine Comorbidities in Patients with Psoriatic Arthritis: A Population-based Case-controlled Study.
    J Rheumatol 2017 Jun 15;44(6):786-790. Epub 2017 Apr 15.
    From the Department of Rheumatology, and the Department of Internal Medicine, and the Department of Community Medicine and Epidemiology, Carmel Medical Center; Bruce and Ruth Rappaport Faculty of Medicine Technion, Haifa; Chief Physician's Office, Central Headquarters, Clalit Health Services, Tel Aviv; Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheba, Israel.
    Objective: To investigate endocrine comorbidities in patients with psoriatic arthritis (PsA).

    Methods: A retrospective, cross-sectional study was performed with the database of Clalit Health Services, the largest healthcare provider in Israel, between 2002 and 2014. Patients with PsA were identified and matched by age and sex to healthy controls. Read More

    Health-related quality of life of patients with hypothalamic-pituitary-adrenal axis dysregulations: a cohort study.
    Eur J Endocrinol 2017 Jul 12;177(1):1-8. Epub 2017 Apr 12.
    Université Paris DescartesSorbonne Paris Cité, Paris, France
    Objective: Health-related quality of life (HrQoL) is increasingly considered to be an important outcome of care for hypothalamic-pituitary-adrenal (HPA) axis dysregulation. The objective of this study was to assess the influence of type of HPA axis dysregulation and cortisol status on HrQOL and its evolution with time and treatment.

    Design: Prospective cohort study. Read More

    A Complex Interplay: Cognitive Behavioural Therapy for Severe Health Anxiety in Addison's Disease to Reduce Emergency Department Admissions.
    Behav Cogn Psychother 2017 Jul 9;45(4):419-426. Epub 2017 Apr 9.
    Department of Psychology,University of Bath,Bath,UK.
    Background: Addison's disease (AD) is a rare chronic illness caused by adrenocortical insufficiency. Due to the pivotal role of the regulating hormone cortisol in AD, there is a common symptom overlap between the presentation of anxiety and adrenal crisis. Previous literature has identified the prevalence of anxiety in endocrinological disorders, however there is a paucity of research examining the complex interplay between AD and anxiety. Read More

    A Naturalistic Study of Driving Behavior in Older Adults and Preclinical Alzheimer Disease.
    J Appl Gerontol 2017 Jan 1:733464817690679. Epub 2017 Jan 1.
    1 Washington University in St. Louis, MO, USA.
    A clinical consequence of symptomatic Alzheimer's disease (AD) is impaired driving performance. However, decline in driving performance may begin in the preclinical stage of AD. We used a naturalistic driving methodology to examine differences in driving behavior over one year in a small sample of cognitively normal older adults with ( n = 10) and without ( n = 10) preclinical AD. Read More

    Comprehensiveness of HIV care provided at global HIV treatment sites in the IeDEA consortium: 2009 and 2014.
    J Int AIDS Soc 2017 01;20(1):20933
    Vanderbilt Institute for Global Health (VIGH), Nashville, TN, USA.
    Introduction: An important determinant of the effectiveness of HIV treatment programs is the capacity of sites to implement recommended services and identify systematic changes needed to ensure that invested resources translate into improved patient outcomes. We conducted a survey in 2014 of HIV care and treatment sites in the seven regions of the International epidemiologic Database to Evaluate AIDS (IeDEA) Consortium to evaluate facility characteristics, HIV prevention, care and treatment services provided, laboratory capacity, and trends in the comprehensiveness of care compared to data obtained in the 2009 baseline survey.

    Methods: Clinical staff from 262 treatment sites in 45 countries in IeDEA completed a site survey from September 2014 to January 2015, including Asia-Pacific with Australia (n = 50), Latin America and the Caribbean (n = 11), North America (n = 45), Central Africa (n = 17), East Africa (n = 36), Southern Africa (n = 87), and West Africa (n = 16). Read More

    Cashew consumption reduces total and LDL cholesterol: a randomized, crossover, controlled-feeding trial.
    Am J Clin Nutr 2017 May 29;105(5):1070-1078. Epub 2017 Mar 29.
    Biofortis Inc., Addison, IL; and
    Background: Cashews are the third most-consumed tree nut in the United States and are abundant with monounsaturated fatty acids and polyunsaturated fatty acids, which are associated with reduced cardiovascular disease risk. Although a qualified Food and Drug Administration health claim exists for nuts and heart health, cashews have been exempt from its use because cashews exceed the disqualifying amount of saturated fatty acids. Approximately one-third of the saturated fat in cashews is stearic acid, which is relatively neutral on blood lipids, thereby suggesting that cashews could have effects that are similar to those of other nuts. Read More

    Subclinical Atherosclerosis, Statin Eligibility, and Outcomes in African American Individuals: The Jackson Heart Study.
    JAMA Cardiol 2017 Jun;2(6):644-652
    Cardiovascular Medicine Division, Department of Medicine, University of Michigan, Ann Arbor.
    Importance: Modern prevention guidelines substantially increase the number of individuals who are eligible for treatment with statins. Efforts to refine statin eligibility via coronary calcification have been studied in white populations but not, to our knowledge, in large African American populations.

    Objective: To compare the relative accuracy of US Preventive Services Task Force (USPSTF) and American College of Cardiology/American Heart Association (ACC/AHA) recommendations in identifying African American individuals with subclinical and clinical atherosclerotic cardiovascular disease (ASCVD). Read More

    Long-term safety of once-daily, dual-release hydrocortisone in patients with adrenal insufficiency: a phase 3b, open-label, extension study.
    Eur J Endocrinol 2017 Jun 14;176(6):715-725. Epub 2017 Mar 14.
    Department of EndocrinologySahlgrenska University Hospital and Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Objective: To investigate the long-term safety and tolerability of a once-daily, dual-release hydrocortisone (DR-HC) tablet as oral glucocorticoid replacement therapy in patients with primary adrenal insufficiency (AI).

    Design: Prospective, open-label, multicenter, 5-year extension study of DR-HC conducted at five university clinics in Sweden.

    Methods: Seventy-one adult patients diagnosed with primary AI who were receiving stable glucocorticoid replacement therapy were recruited. Read More

    Long-term outcome of patients with X-linked adrenoleukodystrophy: A retrospective cohort study.
    Eur J Paediatr Neurol 2017 Jul 21;21(4):600-609. Epub 2017 Feb 21.
    Division of Clinical and Metabolic Genetics, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Canada; Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada.
    Background: X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder associated with leukodystrophy, myeloneuropathy and adrenocortical insufficiency. We performed a retrospective cohort study to evaluate long-term outcome of patients with X-ALD.

    Method: All patients with X-ALD diagnosed between 1989 and 2012 were included. Read More

    Perception of Policy and Environmental Action to Promote Healthy Behaviors in African American Communities.
    Int J Environ Res Public Health 2017 Mar 7;14(3). Epub 2017 Mar 7.
    Center of Excellence in Minority Health and Health Disparities, School of Public Health, Jackson State University, 350 West Woodrow Wilson Drive, Suite, 2280, Jackson, MS 39213, USA.
    The present study aimed to examine the perceptions of African American communities regarding the involvement of political leaders in facilitating policy and environmental change promoting healthy eating and physical activity. We selected the Metro Jackson Area comprised of Hinds, Madison and Rankin Counties because it is a combination of urban and rural communities. The sample consisted of 70 participants from seven sites. Read More

    Video monitoring of oxygen saturation during controlled episodes of acute hypoxia.
    Conf Proc IEEE Eng Med Biol Soc 2016 Aug;2016:4747-4750
    A method for extracting video photoplethysmographic information from an RGB video stream is tested on data acquired during a porcine model of acute hypoxia. Cardiac pulsatile information was extracted from the acquired signals and processed to determine a continuously reported oxygen saturation (SvidO2). A high degree of correlation was found to exist between the video and a reference from a pulse oximeter. Read More

    Combination of dabrafenib plus trametinib for BRAF and MEK inhibitor pretreated patients with advanced BRAF(V600)-mutant melanoma: an open-label, single arm, dual-centre, phase 2 clinical trial.
    Lancet Oncol 2017 Apr 4;18(4):464-472. Epub 2017 Mar 4.
    Department of Medical Oncology, UZ Brussel, Brussels, Belgium. Electronic address:
    Background: Patients with BRAF(V600)-mutant melanoma benefit from treatment with the combination of BRAF and MEK inhibitors, but resistance and disease progression develops in most patients. Preclinical studies and case studies have indicated that acquired resistance to BRAF inhibition can be reversible. We aimed to assess the anti-tumour activity of rechallenge with BRAF plus MEK inhibition in a prospective clinical trial. Read More

    Pharyngeal Residue and Aspiration and the Relationship with Clinical/Nutritional Status of Patients with Oropharyngeal Dysphagia Submitted to Videofluoroscopy.
    J Nutr Health Aging 2017 ;21(3):336-341
    Emilia Addison Machado Moreira, Departamento de Nutrição, Universidade Federal de Santa Catarina UFSC. Campus Universitário, Trindade, s/n, Florianópolis, Santa Catarina, Brazil. Zip Code: 88.040-970. Phone: +55 48 37219784, Fax: +55 48 37219542, E-mail address:
    Objectives: The aim of this study was to investigate the association between the videofluoroscopic (VFS) signs of impaired efficacy (pharyngeal residue) and safety (aspiration) swallowing and the clinical/nutritional status of patients with suspect of dysphagia.

    Design: A cross-sectional study was conducted with patients submitted to videofluoroscopy.

    Setting And Participants: Data of 76 patients were analyzed between March 2011 and December 2014. Read More

    Glucocorticoid-deficient hypoadrenocorticism secondary to intravascular lymphoma in the adrenal glands of a dog.
    Aust Vet J 2017 Mar;95(3):64-67
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
    Case Report: A 2-year-old neutered male German Shepherd dog was presented with weakness, poor appetite and weight loss. Glucocorticoid-deficient hypoadrenocorticism was diagnosed with undetectable pre- and post-ACTH cortisol concentrations but normal sodium and potassium concentrations. Despite appropriate supplementation with glucocorticoids, the patient's weakness progressed and neurological deficits developed. Read More

    Optimistic Bias, Risk Factors, and Development of High Blood Pressure and Obesity among African American Adolescents in Mississippi (USA).
    Int J Environ Res Public Health 2017 Feb 20;14(2). Epub 2017 Feb 20.
    Center of Excellence in Minority Health and Health Disparities, School of Public Health, Jackson State University, Jackson, MS 39213, USA.
    Childhood obesity has reached epidemic proportions and is linked to hypertension among African American youth. Optimistic bias influences behavior of youth causing them to underestimate their susceptibility to negative health outcomes. This study explored adolescent behaviors and prevalence of high blood pressure and obesity in a school district. Read More

    Primary adrenal insufficiency is associated with impaired natural killer cell function: a potential link to increased mortality.
    Eur J Endocrinol 2017 Apr;176(4):471-480
    Institute of Metabolism and Systems ResearchUniversity of Birmingham, Birmingham, UK
    Objective: Mortality in patients with primary adrenal insufficiency (PAI) is significantly increased, with respiratory infections as a major cause of death. Moreover, patients with PAI report an increased rate of non-fatal infections. Neutrophils and natural killer (NK) cells are innate immune cells that provide frontline protection against invading pathogens. Read More

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