5,565 results match your criteria Addison Disease


NLA scientific statement on statin intolerance: a new definition and key considerations for ASCVD risk reduction in the statin intolerant patient.

J Clin Lipidol 2022 Jun 9. Epub 2022 Jun 9.

Department of Applied Health Science, School of Public Health, Indiana University, Bloomington, IN and Midwest Biomedical Research, 211 E. Lake St., Ste 3, Addison, IL 60101, United States (Dr Maki). Electronic address:

Although statins are generally well tolerated, statin intolerance is reported in 5-30% of patients and contributes to reduced statin adherence and persistence, as well as higher risk for adverse cardiovascular outcomes. This Scientific Statement from the National Lipid Association was developed to provide an updated definition of statin intolerance and to inform clinicians and researchers about its identification and management. Statin intolerance is defined as one or more adverse effects associated with statin therapy which resolves or improves with dose reduction or discontinuation and can be classified as a complete inability to tolerate any dose of a statin or partial intolerance with inability to tolerate the dose necessary to achieve the patient-specific therapeutic objective. Read More

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Cardiovascular Imaging in Cardio-Oncology: The Role of Echocardiography and Cardiac MRI in Modern Cardio-Oncology.

Heart Fail Clin 2022 Jul;18(3):455-478

Cardio-Oncology Program, Division of Cardiology, The Ohio State University Medical Center, Columbus, OH, USA; Division of Cancer Prevention and Control, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, USA. Electronic address:

Cardiovascular (CV) events are an increasingly common limitation of effective anticancer therapy. Over the last decade imaging has become essential to patients receiving contemporary cancer therapy. Herein we discuss the current state of CV imaging in cardio-oncology. Read More

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Bilateral Primary Adrenal B-Cell Lymphoma Diagnosed by Workup for Primary Adrenal Deficiency.

Gulf J Oncolog 2022 May;1(39):92-96

Gulab Devi Hospital, Al-Aleem Medical College, Pakistan.

Primary adrenal lymphoma (PAL) often occurs bilaterally and is a rare malignancy of old age. Workup for primary adrenal insufficiency often unmasks this underlying grave pathology. In this article, we present a case of a 73-yearold patient who presented with features of primary adrenal insufficiency and renal colic. Read More

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Clinical Profile of Addison's Disease in a Tertiary Care Institute, Southern India - The Changing Landscape.

Indian J Endocrinol Metab 2022 Jan-Feb;26(1):50-54. Epub 2022 Apr 27.

Department of Endocrinology, Madurai Medical College, Madurai, Tamil Nadu, India.

Aims And Objectives: Clinical, biochemical, and radiological profiles of Addison's disease and to assess the various etiological spectrum of primary adrenal insufficiency (PAI) in adults.

Materials And Methods: A retrospective cohort study was carried out in the Department of Endocrinology, Madurai Medical College, Madurai between January 2014 and January 2021 over a 7-year period.

Inclusion Criteria: All the patients with clinical symptoms and or signs of suspected PAI, such as hyperpigmentation, weight loss, persistent nausea or vomiting, fatigue, and hypotension, were recruited. Read More

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Long-Term Follow-Up of Three Family Members with a Novel Pathogenic Variant Causing Primary Adrenal Insufficiency.

Genes (Basel) 2022 Apr 20;13(5). Epub 2022 Apr 20.

Faculty of Medicine, University of Ljubljana, Vrazov Trg 2, SI-1000 Ljubljana, Slovenia.

Nicotinamide nucleotide transhydrogenase (NNT) deficiency causes primary adrenal insufficiency (PAI) and possibly some extra-adrenal manifestations. A limited number of these patients were previously described. We present the clinical and genetic characteristics of three family members with a biallelic novel pathogenic variant in the gene. Read More

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The intersection of gynecologic cancer, obesity, and cardiovascular disease.

Gynecol Oncol 2022 Jun;165(3):403-404

Cardio-Oncology Program, Division of Cardiology, The Ohio State University Wexner Medical Center, Columbus, Ohio.

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Adolescent onset of autoimmune polyglandular syndrome type 2.

BMJ Case Rep 2022 May 20;15(5). Epub 2022 May 20.

Department of Paediatrics, Midland Regional Hospital, Mullingar, Westmeath, Ireland

An adolescent female was evaluated for fatigue, anorexia and unintentional weight loss of 7 kg. Initial investigations revealed subclinical autoimmune thyroid dysfunction, which progressed to overt hypothyroidism necessitating thyroxine replacement. She had entered early puberty, but this did not appear to be progressing. Read More

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Autoimmune polyglandular syndrome type 2: A case report.

Ann Med Surg (Lond) 2022 Jun 16;78:103742. Epub 2022 May 16.

Department of Endocrinology, Aleppo University Hospital, Aleppo, Syria.

Introduction: Autoimmune polyglandular syndrome 2(APS 2) is immune-mediated destruction that affects two or more endocrine glands and causes a constellation of multiple glands insufficiencies.

Case Presentation: we reported a rare case 9 years old male diagnosed with APS 2; he had adrenal insufficiency three years ago due to leak adherence to hydrocortisone. He was admitted to the hospital for adrenal crises after hemodynamic stability; laboratory evaluation showed that he had Hashimoto's thyroiditis, celiac disease, and the glutamic acid decarboxylase antibody (GAD) Anti-islet cell antibodies were positive, so he was also predisposed to DM 1 later. Read More

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Ventricular systolic dysfunction in dogs diagnosed with hypoadrenocorticism.

J Vet Cardiol 2022 Apr 23;41:231-235. Epub 2022 Apr 23.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, 736 Wilson Road, East Lansing, Michigan, 48824, USA. Electronic address:

In human patients with hypoadrenocorticism, a secondary dilated cardiomyopathy is noted that has been reported to resolve with replacement steroid therapy. A similar secondary dilated cardiomyopathy in dogs with hypoadrenocorticism has not been previously described. We present three dogs concurrently diagnosed with hypoadrenocorticism and ventricular dilation with systolic dysfunction. Read More

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Adrenal crises in adolescents and young adults.

Endocrine 2022 Jun 18;77(1):1-10. Epub 2022 May 18.

Department of Endocrinology, Karolinska University Hospital, SE-17176, Stockholm, Sweden.

Purpose: Review the literature concerning adrenal insufficiency (AI) and adrenal crisis (AC) in adolescents and young adults.

Methods: Searches of PubMed identifying relevant reports up to March 2022.

Results: AI is rare disorder that requires lifelong glucocorticoid replacement therapy and is associated with substantial morbidity and occasional mortality among adolescents and young adults. Read More

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Interventions for the prevention of adrenal crisis in adults with primary adrenal insufficiency: a systematic review.

Eur J Endocrinol 2022 Jun 1;187(1):S1-S20. Epub 2022 Jun 1.

School of Nursing, Institute of Clinical Sciences.

Objective: The incidence of adrenal crisis (AC) remains high, particularly for people with primary adrenal insufficiency, despite the introduction of behavioural interventions. The present study aimed to identify and evaluate available evidence of interventions aiming to prevent AC in primary adrenal insufficiency.

Design: This study is a systematic review of the literature and theoretical mapping. Read More

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Diagnosis of canine spontaneous hypoadrenocorticism.

Canine Med Genet 2022 May 3;9(1). Epub 2022 May 3.

University College Dublin Veterinary Hospital, University College Dublin, Dublin, Ireland.

Hypoadrenocorticism is characterized by a reduction in mineralocorticoid and/or glucocorticoid production by the adrenal glands. Several subtypes have been described with different clinical and clinicopathological consequences. Most affected dogs have vague and non-specific signs that precede an eventual life-threatening crisis. Read More

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Metabolomic Abnormalities in Serum from Untreated and Treated Dogs with Hyper- and Hypoadrenocorticism.

Metabolites 2022 Apr 9;12(4). Epub 2022 Apr 9.

Vetsuisse Faculty, University of Zürich, 8057 Zürich, Switzerland.

The adrenal glands play a major role in metabolic processes, and both excess and insufficient serum cortisol concentrations can lead to serious metabolic consequences. Hyper- and hypoadrenocorticism represent a diagnostic and therapeutic challenge. Serum samples from dogs with untreated hyperadrenocorticism ( = 27), hyperadrenocorticism undergoing treatment ( = 28), as well as with untreated ( = 35) and treated hypoadrenocorticism ( = 23) were analyzed and compared to apparently healthy dogs ( = 40). Read More

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Psychotic Disorder as the First Manifestation of Addison Disease: A Case Report.

Int J Endocrinol Metab 2022 Jan 14;20(1):e121011. Epub 2022 Mar 14.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institude, Shariati Hospital, Tehran University of Medical Sciences,Tehran, Iran.

Introduction: Addison disease is a relatively uncommon endocrine disease resulting from adrenal insufficiency. Psychiatric symptoms are among its rare primary and particularly isolated clinical symptoms. This report presents a case with adrenal insufficiency manifested by the psychotic syndrome. Read More

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January 2022

Effect of Recombinant Gonadotropin on Testicular Function and Testicular Sperm Extraction in Five Cases of () Pathogenic Variants.

Front Endocrinol (Lausanne) 2022 30;13:855082. Epub 2022 Mar 30.

Service de Biochimie et Biologie Moléculaire, UM Pathologies Endocriniennes, CR DEV-GEN, Centre de Biologie et Pathologie Est, Hospices Civils de Lyon, Bron, France.

Background: pathogenic variants can cause congenital adrenal hypoplasia or primary adrenal insufficiency in early childhood usually associated with hypogonadotropic hypogonadism. is necessary for organogenesis of the adrenal cortex and to maintain normal spermatogenesis. In humans, restoration of fertility in patients carrying pathogenic variants is challenging. Read More

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Can Digenic, Tri-Allelic Inheritance of Variants in and Give Rise to Primary Adrenal Insufficiency? A Case Report.

Front Endocrinol (Lausanne) 2022 28;13:860055. Epub 2022 Mar 28.

Centre for Endocrinology, William Harvey Research Institute, Queen Mary, University of London, London, United Kingdom.

An eight-year old South Asian boy presenting with progressive hyperpigmentation was found to have primary adrenal insufficiency (PAI) in the form of isolated glucocorticoid deficiency. Follow up of this boy for nine years, until the age of 17 years showed normal pubertal onset and progression. Molecular evaluation, by targeted next generation sequencing of candidate genes linked to PAI revealed changes in two genes that are intricately linked in the early stages of steroid biosynthesis: compound heterozygous variants in , c. Read More

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The genetics of autoimmune Addison disease: past, present and future.

Nat Rev Endocrinol 2022 Jul 11;18(7):399-412. Epub 2022 Apr 11.

Department of Clinical Science, University of Bergen, Bergen, Norway.

Autoimmune Addison disease is an endocrinopathy that is fatal if not diagnosed and treated in a timely manner. Its rarity has hampered unbiased studies of the predisposing genetic factors. A 2021 genome-wide association study, explaining up to 40% of the genetic susceptibility, has revealed new disease loci and reproduced some of the previously reported associations, while failing to reproduce others. Read More

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Racial Disparities in COVID-19 Outcomes Among Black and White Patients With Cancer.

JAMA Netw Open 2022 03 1;5(3):e224304. Epub 2022 Mar 1.

Population Health Sciences, Mays Cancer Center at University of Texas Health San Antonio MD Anderson, San Antonio.

Importance: Non-Hispanic Black individuals experience a higher burden of COVID-19 than the general population; hence, there is an urgent need to characterize the unique clinical course and outcomes of COVID-19 in Black patients with cancer.

Objective: To investigate racial disparities in severity of COVID-19 presentation, clinical complications, and outcomes between Black patients and non-Hispanic White patients with cancer and COVID-19.

Design, Setting, And Participants: This retrospective cohort study used data from the COVID-19 and Cancer Consortium registry from March 17, 2020, to November 18, 2020, to examine the clinical characteristics and outcomes of COVID-19 in Black patients with cancer. Read More

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Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19.

Front Immunol 2022 3;13:834988. Epub 2022 Mar 3.

Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.

Patients with COVID-19 present with a wide variety of clinical manifestations. Thromboembolic events constitute a significant cause of morbidity and mortality in patients infected with SARS-CoV-2. Severe COVID-19 has been associated with hyperinflammation and pre-existing cardiovascular disease. Read More

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COVID-19 and the adaptive evolution of genetic counseling.

J Genet Couns 2022 Mar 18. Epub 2022 Mar 18.

Metis Genetics, Addison, Texas, USA.

Emerging diseases such as the Coronavirus Disease (COVID-19) have exposed severe weaknesses in the United States and global health. Healthcare systems have struggled and are still severely challenged and strained by this pandemic. It is clear that additional resources are needed to support healthcare providers in managing this and future pandemics. Read More

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Young adult Swedish patients with autoimmune Addison's disease report difficulties with executive functions in daily life despite overall good cognitive performance.

Psychoneuroendocrinology 2022 06 10;140:105714. Epub 2022 Mar 10.

Department of Women's and Children's Health, Karolinska Institutet, Pediatric Endocrinology Unit, Karolinska University Hospital, SE-171 76 Stockholm, Sweden. Electronic address:

Objectives: Sub-optimal replacement of glucocorticoids (GC) in autoimmune Addison's disease (AAD) may affect cognitive functioning. The present study therefore sought to investigate cognitive performance and self-reported problems with executive functions in a cohort of young adult patients with AAD.

Design And Methods: 67 patients with AAD (39 females), mean age 32 yrs. Read More

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Current Approach for Diagnosis and Treatment of Adrenal Tuberculosis-Our Experience and Review of Literature.

Surg J (N Y) 2022 Jan 3;8(1):e92-e97. Epub 2022 Mar 3.

Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences, Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Addison's disease was first described by Thomas Addison in 1855. He demonstrated the destruction of bilateral adrenal gland by tuberculosis (TB) in six patients. Since then, the incidence of TB has declined in the Western world, but in developing countries, it is still the most common cause of adrenal insufficiency. Read More

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January 2022

Cardiac tamponade as a presentation of primary adrenal insufficiency.

BMJ Case Rep 2022 Mar 4;15(3). Epub 2022 Mar 4.

Musgrove Park Hospital, Taunton, UK.

Cardiac tamponade is an important and severe consequence of pericardial effusion. Patients with haemodynamically significant pericardial effusions present with signs and symptoms relating to the degree of their impaired cardiac function. Although autoimmune disease is a recognised cause of pericardial effusion, cardiac tamponade as a clinical presentation of primary adrenal insufficiency (PAI) is infrequently reported. Read More

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mHealth Interventions for Self-management of Hypertension: Framework and Systematic Review on Engagement, Interactivity, and Tailoring.

JMIR Mhealth Uhealth 2022 03 2;10(3):e29415. Epub 2022 Mar 2.

Department of Biomedical Informatics, The Ohio State University, Columbus, OH, United States.

Background: Engagement is essential for the effectiveness of digital behavior change interventions. Existing systematic reviews examining hypertension self-management interventions via mobile apps have primarily focused on intervention efficacy and app usability. Engagement in the prevention or management of hypertension is largely unknown. Read More

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A Head-to-Head Comparison of a Free Fatty Acid Formulation of Omega-3 Pentaenoic Acids Versus Icosapent Ethyl in Adults With Hypertriglyceridemia: The ENHANCE-IT Study.

J Am Heart Assoc 2022 03 1;11(6):e024176. Epub 2022 Mar 1.

Matinas BioPharma Inc. Bedminster NJ.

Background MAT9001 is an omega-3 free fatty acid (FFA) formulation containing mainly eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPA). Compared with icosapent ethyl (EPA-ethyl esters [EE]), EPA+DPA-FFA previously showed enhanced triglyceride lowering and higher plasma EPA when both were administered once daily with a very-low fat diet. This trial compared pharmacodynamic responses and plasma omega-3 levels following twice daily dosing, with meals, of EPA+DPA-FFA and EPA-EE in hypertriglyceridemic subjects consuming a Therapeutic Lifestyle Changes diet. Read More

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Autoimmune Thyroid Disorders in Autoimmune Addison Disease.

J Clin Endocrinol Metab 2022 05;107(6):e2331-e2338

Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway.

Context: Autoimmune thyroid disease is the most common endocrine comorbidity in autoimmune Addison disease (AAD), but detailed investigations of prevalence and clinical course are lacking.

Objective: This work aimed to provide comprehensive epidemiological and clinical data on autoimmune thyroid disorders in AAD.

Methods: A nationwide registry-based study including 442 patients with AAD and autoimmune thyroid disease were identified through the Norwegian National Registry of Autoimmune Diseases. Read More

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Identification of QTLs Controlling Resistance to Anthracnose Disease in Water Yam ().

Genes (Basel) 2022 02 14;13(2). Epub 2022 Feb 14.

International Institute of Tropical Agriculture (IITA), Ibadan 5320, Nigeria.

Anthracnose disease caused by a fungus is the primary cause of yield loss in water yam (), the widely cultivated species of yam. Resistance to yam anthracnose disease (YAD) is a prime target in breeding initiatives to develop durable-resistant cultivars for sustainable management of the disease in water yam cultivation. This study aimed at tagging quantitative trait loci (QTL) for anthracnose disease resistance in a bi-parental mapping population of Parent genotypes and their recombinant progenies were genotyped using the Genotyping by Sequencing (GBS) platform and phenotyped in two crop cycles for two years. Read More

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February 2022

Cardiovascular Event Reporting in Modern Cancer Radiation Therapy Trials.

Adv Radiat Oncol 2022 Mar-Apr;7(2):100888. Epub 2021 Dec 29.

Cardio-Oncology Program, Division of Cardiology, Ohio State University Medical Center, Columbus, Ohio.

Purpose: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in cancer survivors, particularly after chest radiation therapy (RT). However, the extent to which CVD events are consistently reported in contemporary prospective trials is unknown.

Methods And Materials: From 10 high-impact RT, oncology, and medicine journals, we identified all latter phase trials from 2000 to 2019 enrolling patients with breast, lung, lymphoma, mesothelioma, or esophageal cancer wherein chest-RT was delivered. Read More

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December 2021

Tongue Muscle for the Analysis of Head Muscle Regeneration Dynamics.

J Dent Res 2022 Feb 22:220345221075966. Epub 2022 Feb 22.

Division of Molecular Signaling and Biochemistry, Kyushu Dental University, Kitakyushu, Fukuoka, Japan.

Tongue muscle damage impairs speaking and eating, thereby degrading overall health and quality of life. Skeletal muscles of the body are diverse in embryonic origin, anatomic location, and gene expression profiles. Responses to disease, atrophy, aging, or drugs vary among different muscles. Read More

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February 2022

Severe weight loss in a hypothyroid patient as an acute presentation of autoimmune polyglandular syndrome type II.

Hormones (Athens) 2022 Jun 19;21(2):317-322. Epub 2022 Feb 19.

Faculty of Health and Medical Research, Copenhagen University, Copenhagen, Denmark.

Background: Autoimmune disease, including autoimmune thyroid disease, with uncharacteristic symptoms can be due to additional severe disease. We report a life-threatening debut of autoimmune polyglandular syndrome type II (APS II) defined as Addison's disease combined with autoimmune diabetes and/or thyroid disease.

Patient Findings: A 33-year-old male with newly diagnosed hypothyroidism was referred to a tertiary center due to fatigue and 20-kg rapid weight loss. Read More

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