6,732 results match your criteria Addison Disease


The plasma peptidome.

Clin Proteomics 2018 1;15:39. Epub 2018 Dec 1.

1Ryerson Analytical Biochemistry Laboratory (RABL), Department of Chemistry and Biology, Faculty of Science, Ryerson University, 350 Victoria St, Toronto, ON Canada.

Background: It may be possible to discover new diagnostic or therapeutic peptides or proteins from blood plasma using LC-ESI-MS/MS to identify, with a linear quadrupole ion trap to identify, quantify and compare the statistical distributions of peptides cleaved ex vivo from plasma samples from different clinical populations.

Methods: A systematic method for the organic fractionation of plasma peptides was applied to identify and quantify the endogenous tryptic peptides from human plasma from multiple institutions by C18 HPLC followed nano electrospray ionization and tandem mass spectrometry (LC-ESI-MS/MS) with a linear quadrupole ion trap. The endogenous tryptic peptides, or tryptic phospho peptides (i. Read More

View Article
December 2018

Age may influence the impact of TRAbs on thyroid function and relapse-risk in patients with Graves' disease.

J Clin Endocrinol Metab 2018 Dec 3. Epub 2018 Dec 3.

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

Context: Thyrotropin receptor antibodies (TRAbs) play a crucial role in the pathogenesis of Graves' disease (GD). However, factors that influence the association of TRAbs with thyroid hormones and relapse risk in GD remain unclear.

Objective: We investigated: (i) the associations of TRAbs at diagnosis with thyroid hormones and relapse risk; (ii) potential factors that can influence these associations in GD. Read More

View Article
December 2018

Do Out-of-Hospital Cardiac Arrest Patients Have Increased Chances of Survival When Transported to a Cardiac Resuscitation Center?

J Am Heart Assoc 2018 Dec;7(23):e011079

6 Université de Montréal Montréal Québec Canada.

Background Patients suffering from an out-of-hospital cardiac arrest are often transported to the closest hospital. Although it has been suggested that these patients be transported to cardiac resuscitation centers, few jurisdictions have acted on this recommendation. To better evaluate the evidence on this subject, a systematic review and meta-analysis of the currently available literature evaluating the association between the destination hospital's capability (cardiac resuscitation center or not) and resuscitation outcomes for adult patients suffering from an out-of-hospital cardiac arrest was performed. Read More

View Article
December 2018

Addison's disease in antiphospholipid syndrome: a rare complication.

Endocrinol Diabetes Metab Case Rep 2018 Nov 22;2018. Epub 2018 Nov 22.

Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.

Addison's disease (AD) is the most common endocrine manifestation of antiphospholipid syndrome (APS), but it remains a very rare complication of the syndrome. It is caused by adrenal venous thrombosis and consequent hemorrhagic infarction or by spontaneous (without thrombosis) adrenal hemorrhage, usually occurring after surgery or anticoagulant therapy. We present a clinical case of a 36-year-old female patient with a previous diagnosis of APS. Read More

View Article
November 2018
2 Reads

SIG-1273 protects skin against urban air pollution and when formulated in AgeIQ™ Night Cream anti-aging benefits clinically demonstrated.

J Cosmet Dermatol 2018 Nov 19. Epub 2018 Nov 19.

Signum Dermalogix, Princeton, New Jersey.

Background: SIG-1273 is a novel cosmetic active that provides a broad spectrum of benefits to the skin. Considering the chronic skin exposure to pollution in urban areas, we sought to determine if SIG-1273 could provide additional protection against skin aging by inhibiting pollutant-induced cytotoxicity and inflammation.

Objective: Determine if SIG-1273 possesses antipollution properties in vitro and evaluate the potential anti-aging benefits of Age IQ™ Night Cream clinically in human subjects. Read More

View Article
November 2018
2 Reads

Four priorities for new links between conservation science and accounting research.

Conserv Biol 2018 Nov 19. Epub 2018 Nov 19.

Department of Zoology, University of Cambridge, The David Attenborough Building, Pembroke Street, Cambridge, CB2 3QZ, U.K.

Article impact statement: New collaborations with accounting research can improve conservation impact of ecosystem-based information systems. Read More

View Article
November 2018

Strength-limiting damage in lithium silicate glass-ceramics associated with CAD-CAM.

Dent Mater 2018 Nov 16. Epub 2018 Nov 16.

University of Alberta, School of Dentistry, Edmonton, AB, Canada. Electronic address:

Objective: The fabrication of all-ceramic restorations using Computer Aided Design and Computer Aided Manufacturing (CAD-CAM) most commonly involves subtractive machining which results in strength-limiting, surface and sub-surface damage in the resultant prosthesis. The objective was to explore how clinically relevant machining-process variables, and material variables, affect damage accumulation in lithium silicate glass-ceramics.

Methods: Three commercial lithium silicate glass-ceramics (IPS e. Read More

View Article
November 2018

The effect of rehabilitation interventions on physical function and immobility-related complications in severe stroke-protocol for a systematic review.

Syst Rev 2018 Nov 17;7(1):197. Epub 2018 Nov 17.

School of Population Health and Environmental Sciences, Faculty of Life Sciences and Medicine, King's College London, Addison House, Guy's Campus, London, SE1 1UL, England.

Background: Stroke rehabilitation aims to optimise function and reduce complications post-stroke. Rehabilitation to optimise physical function post-stroke has beneficial effects for survivors of mild to moderate stroke. However, little is known about the effectiveness of interventions to rehabilitate physical function or manage immobility-related complications for survivors of severe stroke. Read More

View Article
November 2018
3 Reads

The design of additively manufactured lattices to increase the functionality of medical implants.

Mater Sci Eng C Mater Biol Appl 2019 Jan 13;94:901-908. Epub 2018 Oct 13.

School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.

The rise of antibiotic resistant bacterial species is driving the requirement for medical devices that minimise infection risks. Antimicrobial functionality may be achieved by modifying the implant design to incorporate a reservoir that locally releases a therapeutic. For this approach to be successful it is critical that mechanical functionality of the implant is maintained. Read More

View Article
January 2019

Pulsed Transcranial Red/Near-Infrared Light Therapy Using Light-Emitting Diodes Improves Cerebral Blood Flow and Cognitive Function in Veterans with Chronic Traumatic Brain Injury: A Case Series.

Photomed Laser Surg 2018 Nov 28. Epub 2018 Nov 28.

8 Penrose-St. Francis Health Services , Emergency Department, Colorado Springs, Colorado.

Objective: This study explored the outcome of applying red/near-infrared light therapy using light-emitting diodes (LEDs) pulsed with three different frequencies transcranially to treat traumatic brain injury (TBI) in Veterans.

Background: Photobiomodulation therapy (PBMT) using LEDs has been shown to have positive effects on TBI in humans and animal models.

Materials And Methods: Twelve symptomatic military Veterans diagnosed with chronic TBI >18 months post-trauma received pulsed transcranial PBMT (tPBMT) using two neoprene therapy pads containing 220 infrared and 180 red LEDs, generating a power output of 3. Read More

View Article
November 2018
1 Read

Dairy milk proteins attenuate hyperglycemia-induced impairments in vascular endothelial function in adults with prediabetes by limiting increases in glycemia and oxidative stress that reduce nitric oxide bioavailability.

J Nutr Biochem 2018 Sep 25;63:165-176. Epub 2018 Sep 25.

Human Nutrition Program, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

Postprandial hyperglycemia (PPH) transiently impairs vascular endothelial function (VEF) in an oxidative stress-dependent manner by decreasing nitric oxide (NO) bioavailability. Dairy milk and its proteins attenuate PPH, but whether this improves VEF is unknown. We hypothesized that dairy milk, mediated by its whey and/or casein proteins, improves VEF by attenuating PPH-induced oxidative stress that otherwise decreases NO bioavailability. Read More

View Article
September 2018
6 Reads

Implications of X-ray beam profiles on qualitative and quantitative synchrotron micro-focus X-ray fluorescence microscopy.

J Synchrotron Radiat 2018 Nov 28;25(Pt 6):1719-1726. Epub 2018 Sep 28.

Aston Institute of Materials Research, School of Engineering, University of Aston, Birmingham B4 7ET, UK.

Synchrotron radiation X-ray fluorescence microscopy is frequently used to investigate the spatial distribution of elements within a wide range of samples. Interrogation of heterogeneous samples that contain large concentration ranges has the potential to produce image artefacts due to the profile of the X-ray beam. The presence of these artefacts and the distribution of flux within the beam profile can significantly affect qualitative and quantitative analyses. Read More

View Article
November 2018

DELTA guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial.

Trials 2018 Nov 5;19(1):606. Epub 2018 Nov 5.

Health Economics Group, Institute of Health & Society, Newcastle University, Newcastle upon Tyne, NE2 4AX, UK.

Background: A key step in the design of a RCT is the estimation of the number of participants needed in the study. The most common approach is to specify a target difference between the treatments for the primary outcome and then calculate the required sample size. The sample size is chosen to ensure that the trial will have a high probability (adequate statistical power) of detecting a target difference between the treatments should one exist. Read More

View Article
November 2018
3 Reads

Correction to: Using measures of wellbeing for impact evaluation: Proof of concept developed with an Indigenous community undertaking land management programs in northern Australia.

Ambio 2018 Nov 2. Epub 2018 Nov 2.

Division of Tropical Environments and Societies, James Cook University, Building 1, Townsville, QLD, 4811, Australia.

The article "Using measures of wellbeing for impact evaluation: Proof of concept developed with an Indigenous community undertaking land management programs in northern Australia" written by "Silva Larson, Natalie Stoeckl, Diane Jarvis, Jane Addison, Sharon Prior and Michelle Esparon", was originally published electronically on the publisher's internet portal (currently SpringerLink) on 05 May 2018 without open access. Read More

View Article
November 2018
1 Read

Persistent Underrepresentation of Kidney Disease in Randomized, Controlled Trials of Cardiovascular Disease in the Contemporary Era.

J Am Soc Nephrol 2018 Dec 2;29(12):2782-2786. Epub 2018 Nov 2.

Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas;

View Article
December 2018
10 Reads

Beverage Containing Dispersible Yeast β-Glucan Decreases Cold/Flu Symptomatic Days After Intense Exercise: A Randomized Controlled Trial.

J Diet Suppl 2018 Oct 31:1-11. Epub 2018 Oct 31.

a Biofortis , Mérieux NutriSciences , Addison , IL , USA.

In this double-blind, randomized, placebo-controlled parallel study, we examined the effect of dairy-based beverages (250 mL/day) containing 250 mg of dispersible baker's yeast β-glucan (Wellmune) compared to a macronutrient- and calorie-matched control on upper respiratory tract infection (URTI) in marathon runners. Healthy adults running in the 2017 Austin Marathon consumed either β-glucan (N = 132) or control (N = 225) for the 45 days prior to, day of, and 45 days after the marathon (91 days total). Participants completed a daily online survey assessing compliance, training status, and URTI symptoms. Read More

View Article
October 2018
2 Reads

Breast ultrasound utilization in a safety net emergency department.

Emerg Radiol 2018 Oct 30. Epub 2018 Oct 30.

Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard MC 8896, Dallas, TX, 75390-8896, USA.

Purpose: The purpose of this study is to (1) assess the diagnostic yield of ultrasounds performed in the emergency department for suspected breast abscess and determine the rates of reimaging, discordance, and emergent intervention in a large, busy safety net hospital and (2) determine clinical factors significantly associated with abscess as a way to improve patient selection for emergent breast ultrasounds.

Methods: A total of 581 consecutive breast ultrasounds performed in the emergency department for suspected abscess over 15 months were retrospectively reviewed for imaging, demographics, laboratory data, and physical exam findings. Breast abscess was confirmed by combining imaging, clinical, and laboratory data. Read More

View Article
October 2018
12 Reads

Implementing multiple health behaviour change interventions for cardiovascular risk reduction in primary care: a qualitative study.

BMC Fam Pract 2018 Oct 30;19(1):171. Epub 2018 Oct 30.

School of Population Health and Environmental Sciences, Faculty of Life Sciences and Medicine, King's College London, Addison House, Guy's Campus, London, SE1 1UL, UK.

Background: The implementation of multiple health behaviour change interventions for cardiovascular risk reduction in primary care is suboptimal. This study aimed to identify barriers and facilitators to implementing multiple health behaviour change interventions for cardiovascular disease (CVD) risk reduction in primary care.

Methods: Qualitative study using semi-structured interviews informed by the Theoretical Domains Framework. Read More

View Article
October 2018
6 Reads

Aerosol Optical Properties and Climate Implications of Emissions from Traditional and Improved Cookstoves.

Environ Sci Technol 2018 Nov 8;52(22):13647-13656. Epub 2018 Nov 8.

Carnegie Mellon University , 5000 Forbes Avenue , Pittsburgh , Pennsylvania 15213 , United States.

Cookstove emissions are a major global source of black carbon but their impact on climate is uncertain because of limited understanding of their optical properties. We measured optical properties of fresh aerosol emissions from 32 different stove/fuel combinations, ranging from simple open fires to high-performing forced-draft stoves. Stoves were tested in the laboratory using the firepower sweep protocol, which measures emissions across the entire range of functional firepower. Read More

View Article
November 2018
1 Read

21-hydroxylase autoantibodies are more prevalent in Turner syndrome but without an association to the autoimmune polyendocrine syndrome type I.

Clin Exp Immunol 2018 Oct 29. Epub 2018 Oct 29.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Denmark.

Turner syndrome (TS) is associated with an increased frequency of autoimmunity. Frequently observed autoimmune diseases in TS are also seen in the autoimmune polyendocrine syndrome type I (APS I), of which Addison disease is a key component. An overlapping antibody profile between TS and APS I could be considered. Read More

View Article
October 2018
2 Reads

Comparing ST-segment elevation myocardial infarction care between patients residing in central and remote locations: a retrospective case series.

Rural Remote Health 2018 Oct 27;18(4):4618. Epub 2018 Oct 27.

NHS Highland, Cardiac Unit, Raigmore Hospital, Inverness, IV2 3UJ, UK

Introduction: People who experience an ST-elevation myocardial infarction (STEMI) due to an occluded coronary artery require prompt treatment. Treatments to open a blocked artery are called reperfusion therapies (RTs) and can include intravenous pharmacological thrombolysis (TL) or primary percutaneous coronary intervention (pPCI) in a cardiac catheterisation laboratory (cath lab). Optimal RT (ORT) with pPCI or TL reduces morbidity and mortality. Read More

View Article
October 2018

Dairy milk, regardless of fat content, protects against postprandial hyperglycemia-mediated impairments in vascular endothelial function in adults with prediabetes by limiting oxidative stress responses that reduce nitric oxide bioavailability.

J Nutr Biochem 2018 Oct 16;63:129-139. Epub 2018 Oct 16.

Human Nutrition Program, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

Postprandial hyperglycemia (PPH) transiently impairs vascular endothelial function (VEF) in an oxidative-stress-dependent manner by decreasing nitric oxide (NO) bioavailability. Dairy milk, regardless of fat content, attenuates PPH, but whether this improves VEF by limiting oxidative stress responses that otherwise decrease NO bioavailability is not known. We hypothesized that nonfat and full-fat dairy milk would similarly improve VEF by attenuating PPH-induced oxidative stress that otherwise decreases NO biosynthesis and bioavailability. Read More

View Article
October 2018
1 Read

Management of High and Very High-Risk Subjects with Familial Hypercholesterolemia: Results from an Observational Study in Bulgaria.

Folia Med (Plovdiv) 2018 Sep;60(3):389-396

Department of General Medicine, Amgen Europe GmbH,Cambridge, United Kingdom.

Background: Familial hypercholesterolaemia (FH) is a genetic disorder causing accelerated atherosclerosis and premature cardiovascular disease (CVD). This retrospective observational study examined the clinical characteristics and management of FH subjects in Bulgaria over a 12-month period.

Materials And Methods: Twelve cardiology sites participated in this study from May 2015 to May 2016. Read More

View Article
September 2018
1 Read

Hierarchical spidroin micellar nanoparticles as the fundamental precursors of spider silks.

Proc Natl Acad Sci U S A 2018 11 22;115(45):11507-11512. Epub 2018 Oct 22.

Department of Chemistry and Biochemistry, San Diego State University (SDSU), San Diego, CA 92182;

Many natural silks produced by spiders and insects are unique materials in their exceptional toughness and tensile strength, while being lightweight and biodegradable-properties that are currently unparalleled in synthetic materials. Myriad approaches have been attempted to prepare artificial silks from recombinant spider silk spidroins but have each failed to achieve the advantageous properties of the natural material. This is because of an incomplete understanding of the in vivo spidroin-to-fiber spinning process and, particularly, because of a lack of knowledge of the true morphological nature of spidroin nanostructures in the precursor dope solution and the mechanisms by which these nanostructures transform into micrometer-scale silk fibers. Read More

View Article
November 2018
4 Reads

Geranylgeraniol-induced Myogenic Differentiation of C2C12 Cells.

In Vivo 2018 Nov-Dec;32(6):1427-1431

Division of Molecular Signaling and Biochemistry, Kyushu Dental University, Kitakyushu, Japan

Background: Geranylgeraniol (GGOH) is a C20 isoprenoid found in fruits, vegetables, and grains, including rice. As a food substance, GGOH is categorized as 'Generally Recognized as Safe'. GGOH is an intermediate product in the mevalonate pathway and acts as a precursor to geranylgeranyl pyrophosphate. Read More

View Article
August 2018
3 Reads

Geranylgeraniol Induces PPARγ Expression and Enhances the Biological Effects of a PPARγ Agonist in Adipocyte Lineage Cells.

In Vivo 2018 Nov-Dec;32(6):1339-1344

Division of Molecular Signaling and Biochemistry, School of Oral Health Sciences, Kyushu Dental University, Kitakyushu, Japan

Background: The global incidence of diabetes mellitus (DM) has risen precipitously, even in middle- and low-income countries. Peroxisome proliferator-activated receptor γ (PPARγ) plays an important role in the control of cellular glucose metabolism. Activation of PPARγ beneficially results in increased insulin sensitivity. Read More

View Article
July 2018
2 Reads

A qualitative investigation of the role of sport coaches in designing and delivering a complex community sport intervention for increasing physical activity and improving health.

BMC Public Health 2018 Oct 22;18(1):1196. Epub 2018 Oct 22.

Department of Primary Care and Public Health Sciences, King's College London, Addison House, Guy's, London, SE1 1UL, UK.

Background: Community sport can potentially help to increase levels of physical activity and improve public health. Sport coaches have a role to play in designing and implementing community sport for health. To equip the community sport workforce with the knowledge and skills to design and deliver sport and empower inactive participants to take part, this study delivered a bespoke training package on public health and recruiting inactive people to community sport for sport coaches. Read More

View Article
October 2018

Equal North: how can we reduce health inequalities in the North of England? A prioritization exercise with researchers, policymakers and practitioners.

J Public Health (Oxf) 2018 Oct 20. Epub 2018 Oct 20.

Institute of Health and Society, Newcastle University, Baddiley Clark Building, Richardson Road, Newcastle Upon Tyne, UK.

Background: The Equal North network was developed to take forward the implications of the Due North report of the Independent Inquiry into Health Equity. The aim of this exercise was to identify how to reduce health inequalities in the north of England.

Methods: Workshops (15 groups) and a Delphi survey (3 rounds, 368 members) were used to consult expert opinion and achieve consensus. Read More

View Article
October 2018

Substitution of Corn Starch with Resistant Starch Type 4 in a Breakfast Bar Decreases Postprandial Glucose and Insulin Responses: A Randomized, Controlled, Crossover Study.

Curr Dev Nutr 2018 Oct 9;2(10):nzy066. Epub 2018 Aug 9.

Biofortis, Mérieux NutriSciences, Addison, IL.

Background: Resistant starches type 4 (RS4) are chemically modified starches that are resistant to digestion by human enzymes.

Objective: We aimed to test our hypothesis that replacement of standard starch with RS4 in a baked breakfast bar would decrease postprandial glycemic and insulinemic responses in healthy adults.

Methods: In this double-blind, randomized crossover study, 21 healthy adults [10 men; 20-45 y old; BMI (kg/m): 19. Read More

View Article
October 2018

[Genetics of pheochromocytoma and the relevance in surgery].

Chirurg 2018 Oct 10. Epub 2018 Oct 10.

Medizinische Universitätsklinik, Universitätsklinikum Freiburg, Freiburg, Deutschland.

Chromaffin tumors, e.g. pheochromocytomas and paragangliomas are caused by germline mutations of several susceptibility genes in 30-40% of the patients. Read More

View Article
October 2018
7 Reads

Wooden spatula sinusitis following maxillary expansion surgery.

Ann R Coll Surg Engl 2018 Oct 5:e1-e3. Epub 2018 Oct 5.

James Paget University Hospitals NHS Foundation Trust, Great Yarmouth , Norfolk , UK.

Sinusitis is a recognised rare complication of palatine expansion procedures and is usually caused by the presence of an oroantral fistula. We report the first case of unilateral sinusitis as a result of a retained foreign body (a wooden spatula) following a surgically assisted rapid palatine expansion procedure. Read More

View Article
October 2018
4 Reads

Global cities and cultural diversity: challenges and opportunities for young people's nutrition.

Proc Nutr Soc 2018 Nov 27;77(4):456-469. Epub 2018 Sep 27.

Department of Nutritional Sciences,School of Life Course Sciences,Faculty of Life Sciences & Medicine,King's College London,Franklin Wilkins Building,London SE1 9NH,UK.

Childhood obesity is a common concern across global cities and threatens sustainable urban development. Initiatives to improve nutrition and encourage physical exercise are promising but are yet to exert significant influence on prevention. Childhood obesity in London is associated with distinct ethnic and socio-economic patterns. Read More

View Article
November 2018
7 Reads

Glass ionomer cements with milled, dry chlorhexidine hexametaphosphate filler particles to provide long-term antimicrobial properties with recharge capacity.

Dent Mater 2018 Dec 21;34(12):1717-1726. Epub 2018 Sep 21.

Oral Nanoscience, Bristol Dental School, University of Bristol, UK; Pertinax Pharma Ltd., Bristol, UK. Electronic address:

Objective: Glass ionomer cements (GICs) are a versatile material, offering the opportunity for ion exchange with the oral environment. The aim of this study was to develop a GIC that delivers a controlled, rechargeable dose of chlorhexidine (CHX) over an extended period without compromising mechanical properties.

Methods: GICs were supplemented with finely milled particles of chlorhexidine hexametaphosphate (CHX-HMP). Read More

View Article
December 2018
10 Reads
3.770 Impact Factor

Home Environment-Focused Intervention Improves Dietary Quality: A Secondary Analysis From the Healthy Homes/Healthy Families Randomized Trial.

J Nutr Educ Behav 2018 Sep 18. Epub 2018 Sep 18.

Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory University, Atlanta, GA.

Objective: Estimate Healthy Homes/Healthy Families (HHHF) intervention efficacy for improving dietary quality.

Methods: Low-income overweight and obese women (n = 349) recruited from rural community health centers were randomized to receive HHHF, a 16-week home environment-focused coaching intervention or health education materials by mail. Healthy Eating Index-2010 scores were calculated from 2 24-hour dietary recalls collected at baseline and 6- and 12-month follow-up. Read More

View Article
September 2018

Low-dose ACTH stimulation testing in dogs suspected of hypoadrenocorticism.

J Vet Intern Med 2018 Nov 19;32(6):1886-1890. Epub 2018 Sep 19.

Department of Clinical Sciences, Auburn University, Auburn, Alabama.

Background: Low-dose ACTH stimulation testing would lower cost and may increase sensitivity for identification of partial ACTH deficiency.

Hypothesis: (1) The low-dose ACTH stimulation test will provide comparable results to the standard-dose ACTH stimulation test in dogs suspected of hypoadrenocorticism and (2) partial ACTH deficiency exists in dogs and can result in chronic, intermittent gastrointestinal signs.

Animals: Thirty-one client-owned dogs suspected of having hypoadrenocorticism. Read More

View Article
November 2018
4 Reads

Crystal structure of bis-(pivaloyl-hydroxamato-κ,')copper(II).

Acta Crystallogr E Crystallogr Commun 2018 Sep 31;74(Pt 9):1384-1387. Epub 2018 Aug 31.

Department of Chemistry, Purdue University, 560 Oval Dr., West Lafayette, IN 47907-2084, USA.

Reaction of copper(II) nitrate with pivaloyl-hydroxamic acid yielded the title compound, [Cu(pivHA)] (where pivHA is pivaloyl hydroxamate, CHNO). The centrosymmetric mononuclear complex consists of a Cu ion, which is located on a center of inversion, with two coordinated pivaloyl hydroxamate monoanions. The Cu ion has a square-planar coordination environment consisting of four O atoms - two carbonyl O atoms and two hydroxamate O atoms from two hydroxamate pivHA ligands. Read More

View Article
September 2018

In Situ Synchrotron X-Ray Diffraction Characterization of Corrosion Products of a Ti-Based Metallic Glass for Implant Applications.

Adv Healthc Mater 2018 Nov 16;7(21):e1800338. Epub 2018 Sep 16.

School of Metallurgy and Materials, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Ti-based bulk metallic glasses are under consideration for implants due to their high yield strength and biocompatibility. In this work, in situ synchrotron X-ray diffraction (XRD) is used to investigate the corrosion products formed from corrosion of Ti Zr Cu Pd Sn bulk metallic glass in artificial corrosion pits in physiological saline (NaCl). It is found that Pd nanoparticles form in the interior of the pits during electrochemical dissolution. Read More

View Article
November 2018
1 Read
4.880 Impact Factor

Influence of Cobalt Ions on Collagen Gel Formation and Their Interaction with Osteoblasts.

ACS Omega 2018 Aug 30;3(8):10129-10138. Epub 2018 Aug 30.

Physical Sciences for Health, School of Chemistry, Physical Sciences of Imaging in the Biomedical Sciences, School of Chemistry, Department of BioChemical Engineering, School of Chemical Engineering, and School of Dentistry, University of Birmingham, Edgbaston, B15 2TT Birmingham, U.K.

Metals on metal implants have long been used in arthroplasties because of their robustness and low dislocation rate. Several relatively low-corrosion metals have been used in arthroplasty, including 316L stainless steel, titanium, and cobalt-chromium-molybdenum alloy. Debris from these implants, however, has been found to cause inflammatory responses leading to unexpected failure rates approaching 10% 7 years surgery. Read More

View Article
August 2018
3 Reads

Development and Validation of the Coeliac Disease Food Attitudes and Behaviours Scale.

Gastroenterol Res Pract 2018 19;2018:6930269. Epub 2018 Aug 19.

School of Psychology, University of Birmingham, 52 Pritchatts Road, Edgbaston, Birmingham B15 2SB, UK.

Objectives: Previous studies on coeliac disease suggest that attitudes towards the gluten-free diet may contribute to the development of disordered eating. This study describes the development and validation of the Coeliac Disease Food Attitudes and Behaviours scale (CD-FAB) to measure these behaviours in coeliac disease.

Research Methods And Procedures: Focus groups were used to develop 33 potential questionnaire items. Read More

View Article
August 2018
7 Reads

Spider prey-wrapping silk is an α-helical coiled-coil/β-sheet hybrid nanofiber.

Chem Commun (Camb) 2018 Sep;54(76):10746-10749

Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182-1030, USA.

Solid-State NMR results on 13C-Ala/Ser and 13C-Val enriched Argiope argentata prey-wrapping silk show that native, freshly spun aciniform silk nanofibers are dominated by α-helical (∼50% total) and random-coil (∼35% total) secondary structures, with minor β-sheet nanocrystalline domains (∼15% total). This is the most in-depth study to date characterizing the protein structural conformation of the toughest natural biopolymer: aciniform prey-wrapping silks. Read More

View Article
September 2018
6 Reads

Response bias to a randomised controlled trial of a lifestyle intervention in people at high risk of cardiovascular disease: a cross-sectional analysis.

BMC Public Health 2018 Sep 4;18(1):1092. Epub 2018 Sep 4.

Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College Londonz, 10 Cutcombe Road, London, SE5 9RJ, UK.

Background: Research evaluating lifestyle interventions for prevention of cardiovascular disease (CVD) may not reach those most at risk. We compared the response rate to a randomised controlled trial (RCT) of a lifestyle intervention by CVD risk, ethnicity and level of deprivation.

Methods: Primary care patients with a QRisk2 score ≥ 20% were invited to participate in a RCT of an intensive lifestyle intervention versus usual care. Read More

View Article
September 2018
2 Reads

Which individual, social and environmental influences shape key phases in the amphetamine type stimulant use trajectory? A systematic narrative review and thematic synthesis of the qualitative literature.

Addiction 2019 Jan 12;114(1):24-47. Epub 2018 Oct 12.

Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.

Background And Aims: There is limited evidence on what shapes amphetamine-type stimulant (ATS) use trajectories. This systematic narrative review and qualitative synthesis aimed to identify individual, social and environmental influences shaping key phases in the ATS use trajectory: initiation, continuation, increase/relapse and decrease/abstinence.

Methods: MEDLINE, PsycINFO, EMBASE, and PROQUEST (social science premium collection) were searched from 2000 to 2018. Read More

View Article
January 2019
2 Reads

Boundary spanning at the science-policy interface: the practitioners' perspectives.

Sustain Sci 2018 27;13(4):1175-1183. Epub 2018 Mar 27.

16Tasmanian Institute of Agriculture, School of Land and Food, University of Tasmania, Hobart, Tasmania Australia.

Cultivating a more dynamic relationship between science and policy is essential for responding to complex social challenges such as sustainability. One approach to doing so is to "span the boundaries" between science and decision making and create a more comprehensive and inclusive knowledge exchange process. The exact definition and role of boundary spanning, however, can be nebulous. Read More

View Article
March 2018
9 Reads

Intracoronal stress transfer through enamel following RBC photopolymerisation: A synchrotron X-ray study.

Dent Mater 2018 10 14;34(10):1426-1439. Epub 2018 Aug 14.

School of Medical Sciences and Photon Science Institute, University of Manchester, UK.

Objectives: To measure the spatial distribution of crystallographic strain in tooth enamel induced by the photo-polymerisation of a dimethacrylate resin based composite cavity restoration.

Methods: Six sound first premolar teeth, allocated into two groups (n=3), were prepared with mesio-occlusal distal cavities. The enamel was machined at the point of maximum convexity on the outer tooth to create a vertical fin of thickness 100μm and 0. Read More

View Article
October 2018

Reduced Slow-Wave Sleep and Altered Diurnal Cortisol Rhythms in Patients with Addison's Disease.

Eur J Endocrinol 2018 10 16;179(5):319-330. Epub 2018 Oct 16.

K Thomas, Psychology, University of Cape Town, Cape Town, South Africa.

Objectives: Cortisol plays a key role in initiating and maintaining different sleep stages. Patients with Addison's disease (AD) frequently report disrupted sleep, and their hydrocortisone medication regimes do not restore the natural diurnal rhythm of cortisol. However, few studies have investigated relations between sleep quality, especially as measured by polysomnographic equipment, and night-time cortisol concentrations in patients with AD. Read More

View Article
October 2018
1 Read

Empathy Training Through Symptom Burden Simulation.

Am J Hosp Palliat Care 2018 Aug 13:1049909118793113. Epub 2018 Aug 13.

1 Transitions LifeCare, Raleigh, NC, USA.

Background: Providing quality care to hospice and palliative care patients requires the ability to feel and demonstrate empathic behaviors. To acquire a heightened level of empathy, the learner needs to internalize a process of experiencing first-hand real-life symptom burdens common at end of life. Making this happen during new employee orientation is a challenge but with powerful outcomes. Read More

View Article
August 2018
15 Reads

Delayed Presentation of Isolated Adrenocorticotropin Insufficiency after Nivolumab Therapy for Advanced Non-small-cell lung carcinoma (NSCLC).

BMJ Case Rep 2018 Aug 8;2018. Epub 2018 Aug 8.

Internal Medicine, Michigan State University, Lansing, Michigan, USA.

We describe a 73-year-old man who developed adrenal insufficiency 7 months after completing nivolumab therapy for advanced non-small cell lung cancer. He presented with non-specific symptoms of malaise and fatigue with an insidious 13.6 kilogram weight loss, prompting an evaluation for disease progression, which was negative. Read More

View Article
August 2018
17 Reads