5,301 results match your criteria Addison Disease


The altered circadian pattern of basal insulin requirements - an early marker of autoimmune polyendocrine syndromes in type 1 diabetes mellitus.

Endocr Regul 2020 Apr;54(2):126-132

1st Department of Psychiatry, Pavol Jozef Safarik University Faculty of Medicine, Kosice, Slovak Republic.

Objectives: The purpose of the present paper is to propose and introduce novel biomarkers of autoimmune polyendocrine syndromes that are relevant to the early diagnosis and optimal medical management of the patients who already suffer from type 1 diabetes mellitus.

Methods: We hypothesize and demonstrate on a case study that various organ-specific autoimmune endocrinopathies can result in lowered basal insulin requirements, leading to unexplained hypoglycemia.

Results: It can be hypothesized that hypothyroidism in patients with type 1 diabetes mellitus may deteriorate glycemic control and can lead to an increased rate of hypoglycemia, particularly the overnight and morning hypoglycemia. Read More

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http://dx.doi.org/10.2478/enr-2020-0015DOI Listing

Prevalence and characterization of hypoadrenocorticism in dogs with signs of chronic gastrointestinal disease: A multicenter study.

J Vet Intern Med 2020 Jun 23. Epub 2020 Jun 23.

Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University of Munich, Munich, Germany.

Background: Dogs with hypoadrenocorticism (HA) frequently show signs of gastrointestinal disease (SGD). The prevalence of dogs presented for chronic SGD with HA is unknown.

Objectives: The aims of this study were to determine the prevalence of HA in dogs with chronic SGD and to identify clinical and laboratory variables for HA in this population. Read More

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http://dx.doi.org/10.1111/jvim.15752DOI Listing

Community and Socioeconomic Factors Associated with COVID-19 in the United States: Zip code level cross sectional analysis.

medRxiv 2020 Apr 22. Epub 2020 Apr 22.

Background: Multiple reports have pointed towards involvement of community and socioeconomic characteristics of people in the United States may be associated with COVID-19 cases and deaths.

Methods: In this study, zip-code level data from 5 major metropolitan areas, was utilized to study the effect of multiple demographic & socio-economic factors including race, age, income, chronic disease comorbidity, population density, number of people per household on number of positive cases and ensuing death. Adjusted linear regression analysis using 13 to 16 such variables was performed. Read More

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http://dx.doi.org/10.1101/2020.04.19.20071944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277002PMC

Increased risk of endocrine autoimmunity in first-degree relatives of patients with autoimmune Addison's disease.

Eur J Endocrinol 2020 Jul;183(1):73-81

Department of Paediatric Diabetes and Obesity, Poznan University of Medical Sciences, Poznan, Poland.

Objective: Autoimmune conditions tend to cluster in subjects with Addison's disease (AD) and probably also among their relatives. The aim of the study was to estimate the frequency of the endocrine gland-specific autoantibodies in first-degree relatives of patients with AD.

Methods: Autoantibodies were investigated in 113 family members using RIA and ELISA assays. Read More

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http://dx.doi.org/10.1530/EJE-20-0150DOI Listing

Case report of a familial triple: a syndrome and review of the literature.

Medicine (Baltimore) 2020 May;99(22):e20474

Pediatric Unit, Maternal and Child Department, Azienda USL of Reggio Emilia, Sant'Anna Hospital, Castelnovo ne' Monti, Italy.

Rationale: Triple-A syndrome, or Allgrove syndrome (AS), is a rare autosomal recessive disorder characterized by the alacrimia, achalasia, and adrenal insufficiency triad. Alacrimia usually starts at early infancy, while achalasia and adrenal insufficiency appear later during childhood or adulthood. Some patients may also present with the so-called Double-A syndrome (i. Read More

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http://dx.doi.org/10.1097/MD.0000000000020474DOI Listing

Risk of incident autoimmune diseases in patients with thymectomy.

Ann Clin Transl Neurol 2020 Jun 1. Epub 2020 Jun 1.

Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Objectives: The data concerning the association between Tx and ADs remain unclear and are scarce. This study was undertaken to investigate whether people with Tx are more likely to develop ADs, compared to those without Tx.

Methods: Individuals who received Tx between 2002 and 2015 were identified and matched on age and sex with individuals without Tx. Read More

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http://dx.doi.org/10.1002/acn3.51055DOI Listing

A multicentre, randomised controlled trial to compare the clinical and cost-effectiveness of Lee Silverman Voice Treatment versus standard NHS Speech and Language Therapy versus control in Parkinson's disease: a study protocol for a randomised controlled trial.

Trials 2020 May 27;21(1):436. Epub 2020 May 27.

Institute for Applied Health Research, University of Birmingham, Birmingham, B15 2TT, UK.

Background: Parkinson's disease (PD) affects approximately 145,519 people in the UK. Speech impairments are common with a reported prevalence of 68%, which increase physical and mental demands during conversation, reliance on family and/or carers, and the likelihood of social withdrawal reducing quality of life. In the UK, two approaches to Speech and Language Therapy (SLT) intervention are commonly available: National Health Service (NHS) SLT or Lee Silverman Voice Treatment (LSVT LOUD®). Read More

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http://dx.doi.org/10.1186/s13063-020-04354-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251680PMC

Biological stenciling of mineralization in the skeleton: Local enzymatic removal of inhibitors in the extracellular matrix.

Bone 2020 May 23;138:115447. Epub 2020 May 23.

Faculty of Dentistry, McGill University, 3640 University St., Montreal, Quebec H3A 0C7, Canada; Department of Anatomy and Cell Biology, McGill University, 3640 University St., Montreal, Quebec H3A 0C7, Canada. Electronic address:

Biomineralization is remarkably diverse and provides myriad functions across many organismal systems. Biomineralization processes typically produce hardened, hierarchically organized structures usually having nanostructured mineral assemblies that are formed through inorganic-organic (usually protein) interactions. Calcium‑carbonate biomineral predominates in structures of small invertebrate organisms abundant in marine environments, particularly in shells (remarkably it is also found in the inner ear otoconia of vertebrates), whereas calcium-phosphate biomineral predominates in the skeletons and dentitions of both marine and terrestrial vertebrates, including humans. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115447DOI Listing

Current Management and Outcome of Pregnancies in Women With Adrenal Insufficiency: Experience from a Multicenter Survey.

J Clin Endocrinol Metab 2020 Aug;105(8)

Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich, Zürich, Switzerland.

Context: Appropriate management of adrenal insufficiency (AI) in pregnancy can be challenging due to the rarity of the disease and lack of evidence-based recommendations to guide glucocorticoid and mineralocorticoid dosage adjustment.

Objective: Multicenter survey on current clinical approaches in managing AI during pregnancy.

Design: Retrospective anonymized data collection from 19 international centers from 2013 to 2019. Read More

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http://dx.doi.org/10.1210/clinem/dgaa266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320831PMC

Fasting with adrenal insufficiency: Practical guidance for healthcare professionals managing patients on steroids during Ramadan.

Clin Endocrinol (Oxf) 2020 May 18. Epub 2020 May 18.

Department of Diabetes and Endocrinology, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

There are limited recommendations for fasting in many chronic diseases such as adrenal insufficiency (AI). Research in such situations highlights potential for complications and need for education for patients with AI undertaking fasting during Ramadan. This article aimed to provide up-to-date guidance for healthcare professionals to educate, discuss and manage patients with AI who are considering fasting in Ramadan and is religiously compatible. Read More

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http://dx.doi.org/10.1111/cen.14250DOI Listing

Omega-3 fatty acid therapy for cardiovascular disease: justified or not?

Curr Opin Cardiol 2020 Jul;35(4):417-422

Midwest Biomedical Research, Addison, Illinois, Boca Raton, Florida.

Purpose Of Review: To discuss the current evidence regarding the relationship between omega-3 fatty acid intake and atherosclerotic cardiovascular disease (ASCVD) risk.

Recent Findings: Combined results from randomized controlled trials using low-dosage (≤1.8 g/day of ethyl esters) eicosapentaenoic acid (EPA) or EPA + docosahexaenoic acid (DHA) suggest a small benefit for reducing coronary heart disease risk. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000741DOI Listing

Acute illness in patients with concomitant Addison's disease and type 1 diabetes mellitus: Increased incidence of hypoglycaemia and adrenal crises.

Clin Endocrinol (Oxf) 2020 May 12. Epub 2020 May 12.

School of Medicine, Sydney, The University of Notre Dame, Sydney, NSW, Australia.

Background: Patients with Addison's disease (AD) and comorbid type 1 diabetes mellitus (T1DM) are at increased risk of certain acute metabolic disorders relative to patients with one of these conditions only. The reasons for this are unknown.

Methods: All attendances for acute illness by AD patients at the emergency department of a Sydney hospital between 2000 and 2017 were reviewed. Read More

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http://dx.doi.org/10.1111/cen.14219DOI Listing
May 2020
3.457 Impact Factor

Residual Corticosteroid Production in Autoimmune Addison Disease.

J Clin Endocrinol Metab 2020 Jul;105(7)

Department of Clinical Science, University of Bergen, Norway.

Context: Contrary to current dogma, growing evidence suggests that some patients with autoimmune Addison disease (AAD) produce corticosteroids even years after diagnosis.

Objective: To determine frequencies and clinical features of residual corticosteroid production in patients with AAD.

Design: Two-staged, cross-sectional clinical study in 17 centers (Norway, Sweden, and Germany). Read More

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http://dx.doi.org/10.1210/clinem/dgaa256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274491PMC

Snoring is associated with obesity among middle aged Slum-dwelling women in Mysore, India.

Lung India 2020 May-Jun;37(3):210-219

Department of Health Promotion and Disease Prevention, Stempel College of Public Health, Florida International University, Miami, Florida, USA.

Background: Globally, rates of obesity have trebled in the past four decades. India has more than 9.8 million men and 20 million women classified as obese. Read More

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http://dx.doi.org/10.4103/lungindia.lungindia_515_19DOI Listing

Substituting Lean Beef for Carbohydrate in a Healthy Dietary Pattern Does Not Adversely Affect the Cardiometabolic Risk Factor Profile in Men and Women at Risk for Type 2 Diabetes.

J Nutr 2020 Jul;150(7):1824-1833

Midwest Biomedical Research Center for Metabolic and Cardiovascular Health, Addison, IL, USA.

Background: Observational evidence suggests that red meat intake is associated with type 2 diabetes (T2D) and cardiovascular disease incidence, but few randomized controlled trials have assessed effects of lean, unprocessed red meat intake on insulin sensitivity and other cardiometabolic risk factors.

Objective: This study compared the USDA Healthy US-Style Eating Pattern, low in saturated fat and red meat (<40 g/d red meat; USDA-CON), with a modified version with an additional 150 g/d lean beef as an isocaloric replacement for carbohydrate (USDA-LB) on insulin sensitivity and cardiometabolic risk markers.

Methods: Participants (7 men, 26 women; 44. Read More

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http://dx.doi.org/10.1093/jn/nxaa116DOI Listing

Current Perspectives on Coronavirus Disease 2019 and Cardiovascular Disease: A White Paper by the Editors.

J Am Heart Assoc 2020 06 29;9(12):e017013. Epub 2020 Apr 29.

Division of Cardiovascular Medicine Department of Medicine University of Iowa Carver College of Medicine Iowa City IA.

Coronavirus Disease 2019 (COVID-19) has infected more than 3.0 million people worldwide and killed more than 200,000 as of April 27, 2020. In this White Paper, we address the cardiovascular co-morbidities of COVID-19 infection; the diagnosis and treatment of standard cardiovascular conditions during the pandemic; and the diagnosis and treatment of the cardiovascular consequences of COVID-19 infection. Read More

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http://dx.doi.org/10.1161/JAHA.120.017013DOI Listing

Adrenal Insufficiency Due to Bilateral Adrenal Non-Hodgkin's Lymphoma: A Case Report.

Authors:
Fahed S Bangash

Cureus 2020 Mar 22;12(3):e7359. Epub 2020 Mar 22.

Internal Medicine, Hull University Teaching Hospitals NHS Trust, Hull, GBR.

Primary adrenal insufficiency is a rare condition due to the impairment of adrenal glands. Previously, tuberculosis damaging adrenal glands was attributed as the main cause for it; whereas, nowadays autoimmune disease is the most common cause of it. However, rarely metastatic malignancy can cause adrenal insufficiency as well. Read More

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http://dx.doi.org/10.7759/cureus.7359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174869PMC

Nasal Packs for Epistaxis: Predictors of Success.

Authors:

Clin Otolaryngol 2020 Apr 19. Epub 2020 Apr 19.

Objectives: To investigate factors affecting the haemostatic success of non-dissolvable intranasal packs in the management of acute epistaxis presenting to the emergency department (ED).

Design: Prospective cohort study.

Setting: A nationwide prospective audit examining epistaxis management at 113 sites in the UK over a 30-day period. Read More

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http://dx.doi.org/10.1111/coa.13555DOI Listing
April 2020
2.268 Impact Factor

Natural History of Adrenal Steroidogenesis in Autoimmune Addison's Disease Following Diagnosis and Treatment.

J Clin Endocrinol Metab 2020 Jul;105(7)

Institute of Genetic Medicine, International Centre for Life, Newcastle University, Newcastle upon Tyne.

Context: The natural history of adrenal function in autoimmune Addison disease once diagnosed and treated has not been systematically studied, but several case reports of recovery from established adrenal failure suggest it may not be uniform.

Objective: To ascertain steroidogenic function in autoimmune Addison disease immediately following diagnosis and during prolonged treatment.

Design: We studied peak serum cortisol in response to ACTH1-24 in 20 newly diagnosed autoimmune Addison disease patients at first presentation and then again within a month. Read More

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http://dx.doi.org/10.1210/clinem/dgaa187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250207PMC

MANAGEMENT OF ENDOCRINE DISEASE Disease burden and treatment challenges in patients with both Addison's disease and type 1 diabetes mellitus.

Eur J Endocrinol 2020 Jul;183(1):R1-R11

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Concurrent type 1 diabetes (T1D) and Addison's disease (AD) is a rare combination of diseases and, in approximately one third of these patients, it is also combined with an autoimmune thyroid disease. Recently, it was shown that patients with both T1D and AD have a higher risk of premature death compared to patients with T1D alone, the most common causes of death being due to diabetic complications and cardiovascular disease. These patients receiving replacement therapies with both insulin and glucocorticoids face an increased risk of hypo- and hyperglycemia and diabetic ketoacidosis and have a higher risk of adrenal crisis than patients with AD alone. Read More

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http://dx.doi.org/10.1530/EJE-20-0052DOI Listing

An analysis of early morning acth levels in the first case of pembrolizumab-induced adrenalitis as a delayed immune-related event (dire) - case study.

Wiad Lek 2020 ;73(2):396-400

Department Of Internal Medicine Ii, Division Of Gastroenterology, Thuringia Clinic "Georgius Agricola", Saalfeld/Saale, Germany.

Objective: The aim: The levels of adrenocorticotrophic hormone (ACTH) are elevated in primary adrenal failure (Addison's disease) with a peak in the early morning hours. This also occurs under hydrocortisone replacement therapy due to the unphysiological substitution regime. The aim was to study ACTH levels under two different replacement regimens. Read More

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Surfactant Protein-A Protects against IL-13-Induced Inflammation in Asthma.

J Immunol 2020 May 3;204(10):2829-2839. Epub 2020 Apr 3.

Department of Medicine, University of Arizona, Tucson, AZ 85719;

The lung surfactant proteins are recognized as critical not only for their role in lowering lung surface tension but also in innate host defense. Reports have shown that some asthmatic patients have decreased levels of one member of this protein family in particular, surfactant protein-A (SP-A). Our studies set out to determine the contribution of SP-A to the response of a key effector cytokine in asthma, IL-13. Read More

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http://dx.doi.org/10.4049/jimmunol.1901227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304346PMC

Elevated Intracranial Pressure Associated With Exogenous Hormonal Therapy Used for Gender Affirmation.

J Neuroophthalmol 2020 Mar 24. Epub 2020 Mar 24.

Neuro-Ophthalmology Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.

Background: Addison disease, corticosteroid withdrawal, and taking synthetic growth hormone have been linked with development of intracranial hypertension, but there is still debate on whether administration of other exogenous hormones plays a role in precipitating elevated pressure. The growing use of hormonal therapy for gender affirmation provides an opportunity to explore this possibility.

Methods: All transgender patients taking exogenous hormones for female-to-male (FTM) and male-to-female (MTF) transitions who were diagnosed with intracranial hypertension at Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital and Beth Israel Deaconess Medical Center between August 2014 and November 2018 were included in a retrospective review. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000926DOI Listing

[Etiology and clinical features of primary adrenal insufficiency].

Zhonghua Yi Xue Za Zhi 2020 Mar;100(12):915-921

Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Endocrinology of National Health Commission, Beijing 100730, China (Wang Long is now working in the Department of Endocrine and Metabolic Diseases, the Third Affiliated Hospital of Soochow University, Changzhou 213000, China).

To summarize the etiology of primary adrenal insufficiency (PAI) and analyze its clinical features. A retrospective analysis was performed in the Department of Endocrinology, Peking Union Medical College Hospital from October 1981 to June 2019. Patients with PAI as the first symptom were enrolled. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191009-02178DOI Listing

Co-aggregation and heritability of organ-specific autoimmunity: a population-based twin study.

Eur J Endocrinol 2020 May;182(5):473-480

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Objective: Co-aggregation of autoimmune diseases is common, suggesting partly shared etiologies. Genetic factors are believed to be important, but objective measures of environmental vs heritable influences on co-aggregation are absent. With a novel approach to twin studies, we aimed at estimating heritability and genetic overlap in seven organ-specific autoimmune diseases. Read More

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http://dx.doi.org/10.1530/EJE-20-0049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182094PMC

Vitamin B deficiency as a cause of severe neurological symptoms in breast fed infant - a case report.

Ital J Pediatr 2020 Mar 30;46(1):40. Epub 2020 Mar 30.

Department of Neonate and Infant Pathology, Medical University of Lublin, Prof. Gębali 6 str, 20-093, Lublin, Poland.

Background: Vitamin B (cobalamin, cbl) deficiency in children is rare and may occurs in exclusively breast fed infants of mothers on vegetarian or vegan diet with lack of appropriate supplementation. The clinical manifestation of vitamin B12 deficiency include neurological disorders, megaloblastic anemia and failure to thrive. Routine and commonly used laboratory tests such as cell blood count (CBC) or serum vitamin B level are sufficient for appropriate diagnosis. Read More

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http://dx.doi.org/10.1186/s13052-020-0804-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106665PMC

Novel Gene Mutation in a Korean Patient with X-Linked Adrenoleukodystrophy Presenting with Addison's Disease.

Endocrinol Metab (Seoul) 2020 Mar;35(1):188-191

Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.

X-linked adrenoleukodystrophy (X-ALD) occurs due to mutations in the gene that encodes the peroxisomal membrane protein peroxisomal transporter ATP-binding cassette sub-family D member 1 (ABCD1). Degradation of very long-chain fatty acids in peroxisomes is impaired owing to ABCD dysfunction, subsequently leading to adrenomyeloneuropathy, cerebral adrenoleukodystrophy, and adrenal insufficiency. X-ALD frequently induces idiopathic Addison's disease in young male patients. Read More

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http://dx.doi.org/10.3803/EnM.2020.35.1.188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090298PMC

Implementing a Learning Collaborative Framework for States Working to Improve Outcomes for Vulnerable Populations: The Opioid Use Disorder, Maternal Outcomes, and Neonatal Abstinence Syndrome Initiative Learning Community.

J Womens Health (Larchmt) 2020 Apr 13;29(4):475-486. Epub 2020 Mar 13.

Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.

The opioid crisis has impacted vulnerable populations, specifically pregnant and postpartum women, and infants prenatally exposed to substances, including infants with Neonatal Abstinence Syndrome. Lack of access to clinical and social services; potential stigma or discrimination; and lack of resources for provision of services, including screening and treatment, have impacted the health of these populations. In 2018, using a systems change approach, the Association of State and Territorial Health Officials (ASTHO) and the Centers for Disease Control and Prevention (CDC) convened an Opioid use disorder, Maternal outcomes, Neonatal abstinence syndrome Initiative Learning Community (OMNI LC) that included other federal agencies, national clinical and nonclinical organizations, and 12 state leadership groups. Read More

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http://dx.doi.org/10.1089/jwh.2020.8303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259818PMC

Contemporary Trends and Outcomes of Percutaneous and Surgical Mitral Valve Replacement or Repair in Patients With Cancer.

Am J Cardiol 2020 May 8;125(9):1355-1360. Epub 2020 Feb 8.

Cardio-Oncology Program, Division of Cardiology, Ohio State University, Columbus, Ohio; Cancer Control Program, Department of Medicine, Ohio State University Comprehensive Cancer Center, Columbus, Ohio. Electronic address:

In the era of emerging options for mitral valvular intervention, we sought to characterize the relative utilization, outcomes, and posthospital dispositions of patients referred for transcatheter mitral valve repair (TMVRepair) and surgical mitral valve procedures (SMVP), by cancer-status. Leveraging the National Inpatient Sample, a representative national dataset, ICD-9 codes for all adults >18 years with co-morbid mitral regurgitation, and cancer without metastatic disease admitted from 2003 to 2015 were queried. TMVRepair was performed in 700 hospitalizations from 2012 to 2015, whereas SMVP was utilized during 12,863 hospitalizations from 2003 to 2015. Read More

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http://dx.doi.org/10.1016/j.amjcard.2020.01.047DOI Listing

Mass Cytometry Studies of Patients With Autoimmune Endocrine Diseases Reveal Distinct Disease-Specific Alterations in Immune Cell Subsets.

Front Immunol 2020 21;11:288. Epub 2020 Feb 21.

Division of Children and Women Health, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Although there is evidence that autoimmune diseases share similar immunogenetic mechanisms, studies comparing peripheral CD45 cells from patients with autoimmune endocrine diseases in parallel are limited. In this study, we applied high-dimensional single-cell mass cytometry to phenotypically characterize PBMC from patients with new-onset (N-T1D) and long-standing type 1 diabetes, Hashimoto's thyroiditis (HT), Graves' disease and autoimmune Addison's disease (AD), as well as healthy controls. The frequency of CD20CD27CD38HLA-DR plasmablasts, CD86CD14CD16 non-classical monocytes and two subsets of CD56HLA-DRIFN-γ NK cells were increased in patients with HT. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047233PMC
February 2020

Primary antiphospholipid syndrome, Addison disease, and adrenal incidentaloma.

Clin Rheumatol 2020 Jun 7;39(6):1997-2001. Epub 2020 Mar 7.

Direction of Education and Research, Hospital de Especialidades, Centro Médico Nacional "La Raza," IMSS, Seris y Zaachila S/N Col. La Raza CP, 02990, Mexico City, Mexico.

Primary adrenal failure comprises an insufficient production of mineralocorticoids and glucocorticoids in the adrenal cortex. A rare manifestation of antiphospholipid syndrome (APS) is adrenal failure. The majority of patients with adrenal involvement in APS develop an irreversible cortisol deficiency and atrophy of the adrenal glands. Read More

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http://dx.doi.org/10.1007/s10067-020-04978-9DOI Listing

Every Fifth Individual With Type 1 Diabetes Suffers From an Additional Autoimmune Disease: A Finnish Nationwide Study.

Diabetes Care 2020 May 5;43(5):1041-1047. Epub 2020 Mar 5.

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, Helsinki, Finland.

Objective: The aim of this study was to quantify the excess risk of autoimmune hypothyroidism and hyperthyroidism, Addison disease, celiac disease, and atrophic gastritis in adults with type 1 diabetes (T1D) compared with nondiabetic individuals in Finland.

Research Design And Methods: The study included 4,758 individuals with T1D from the Finnish Diabetic Nephropathy (FinnDiane) Study and 12,710 nondiabetic control individuals. The autoimmune diseases (ADs) were identified by linking the data with the Finnish nationwide health registries from 1970 to 2015. Read More

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http://dx.doi.org/10.2337/dc19-2429DOI Listing

Treatment of Catatonic Symptoms in a Patient With Autism Spectrum Disorder and Addison Disease: A Case Report.

J ECT 2020 Jun;36(2):e10-e12

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD Kennedy Krieger Institute, Baltimore, MD.

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http://dx.doi.org/10.1097/YCT.0000000000000670DOI Listing

Cardiovascular Risk Factor Knowledge and Behaviors Among Low-Income Urban Women in Mysore, India.

J Cardiovasc Nurs 2020 Feb 20. Epub 2020 Feb 20.

Karl Krupp, PhD Postdoctoral Fellow, Department of Health Promotion Sciences, Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson; and Public Health Research Institute of India, Mysuru, India. Meredith L. Wilcox, MPH Analyst, Midwest Biomedical Research/Center for Metabolic and Cardiovascular Health, Addison, Illinois; and MB Clinical Research, Boca Raton, Florida. Arun Srinivas, MD Chief of Cardiology, Department of Cardiology, Apollo Hospital, Mysuru, India. Vijaya Srinivas, DGO Senior Research Physician, Public Health Research Institute of India, Mysuru, India. Purnima Madhivanan, PhD Associate Professor, Department of Health Promotion Sciences, Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson; Department of Family & Community Medicine, College of Medicine, University of Arizona, Tucson; Division of Infectious Diseases, College of Medicine, University of Arizona, Tucson; and Public Health Research Institute of India, Mysuru, India. Elena Bastida, PhD Professor and Chair, Department of Health Promotion and Disease Prevention, Stempel College of Public Health, Florida International University, Miami.

Background: Cardiovascular diseases (CVDs) are the leading causes of death among women globally. Cardiovascular disease-related events are more common in older women compared with men and are more likely to result in death. Although research in high-income countries suggests that women have unique sociobiological CVD risk factors, only a few study authors have examined risk factor knowledge among women from low- and middle-income countries. Read More

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http://dx.doi.org/10.1097/JCN.0000000000000657DOI Listing
February 2020

Science dialogue mapping of knowledge and knowledge gaps related to the effects of dairy intake on human cardiovascular health and disease.

Crit Rev Food Sci Nutr 2020 Feb 19:1-17. Epub 2020 Feb 19.

Department of Epidemiology and Biostatistics, Indiana University School of Public Health-Bloomington, Bloomington, Indiana, USA.

Dairy has been described as everything from a superfood to a poison; yet, arguments, assumptions, and data justifying these labels are not always clear. We used an issue-based information system, "dialogue mapping™," to summarize scientific points of a live panel discussion on the putative effects of dairy on cardiovascular diseases (CVD) from a day-long session among experts in nutrition and CVD. Dialogue mapping captures relations among ideas to explicitly, logically, and visually connect issues/questions, ideas, pro/con arguments, and agreements, even if discussed at different times. Read More

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http://dx.doi.org/10.1080/10408398.2020.1722941DOI Listing
February 2020

Reporting of Cardiovascular Events in Clinical Trials Supporting FDA Approval of Contemporary Cancer Therapies.

J Am Coll Cardiol 2020 Feb;75(6):620-628

Cardio-Oncology Program, Division of Cardiology, The Ohio State University Medical Center, Columbus, Ohio; Division of Cancer Prevention and Control, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio. Electronic address:

Background: Cardiovascular disease (CVD) has become an increasingly common limitation to effective anticancer therapy. Yet, whether CVD events were consistently reported in pivotal trials supporting contemporary anticancer drugs is unknown.

Objectives: The authors sought to evaluate the incidence, consistency, and nature of CVD event reporting in cancer drug trials. Read More

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http://dx.doi.org/10.1016/j.jacc.2019.11.059DOI Listing
February 2020

Autoimmune polyglandular syndrome type III associated with antineutrophil cytoplasmic autoantibody-mediated crescentic glomerulonephritis: A case report and literature review.

Medicine (Baltimore) 2020 Feb;99(7):e19179

Department of VIP Unit, China-Japan Union Hospital of Jilin University, Changchun, China.

Rationale: Polyglandular autoimmune syndromes (PAS) are a heterogeneous group of rare diseases characterized by the association of at least 2 organ-specific autoimmune disorders, concerning both the endocrine and nonendocrine organs. Type III is defined as the combination of autoimmune thyroid disease and other autoimmune conditions (other than Addison disease), and is divided into 4 subtypes. We describe a patient with Hashimoto thyroiditis, adult-onset Still disease, alopecia, vasculitis, antineutrophil cytoplasmic antibody (ANCA)-mediated crescentic glomerulonephritis, and hyperparathyroidism. Read More

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http://dx.doi.org/10.1097/MD.0000000000019179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035075PMC
February 2020
5.723 Impact Factor

Characterization of a Pathogenic Variant in the ABCD1 Gene Through Protein Molecular Modeling.

Case Rep Genet 2020 25;2020:3256539. Epub 2020 Jan 25.

Department of Clinical Genomics, Mayo Clinic, Jacksonville, FL 32224, USA.

Background: The ATP-binding cassette, subfamily D, member 1 (ABCD1) protein is a peroxisomal half-transporter that allows for very long chain fatty acid (VLCFA) degradation. Pathogenic variants of cause VLCFAs to build up in various tissues and bodily fluids, resulting in a disorder called X-linked adrenoleukodystrophy (X-ALD). This disorder is most commonly marked by adrenocortical insufficiency and high VLCFA concentration, and has varying levels of neurological involvement depending on phenotype. Read More

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http://dx.doi.org/10.1155/2020/3256539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003284PMC
January 2020

Machine learning algorithm as a diagnostic tool for hypoadrenocorticism in dogs.

Domest Anim Endocrinol 2020 Jul 16;72:106396. Epub 2019 Sep 16.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA. Electronic address:

Canine hypoadrenocorticism (CHA) is a life-threatening condition that affects approximately 3 of 1,000 dogs. It has a wide array of clinical signs and is known to mimic other disease processes, including kidney and gastrointestinal diseases, creating a diagnostic challenge. Because CHA can be fatal if not appropriately treated, there is risk to the patient if the condition is not diagnosed. Read More

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http://dx.doi.org/10.1016/j.domaniend.2019.106396DOI Listing

Autoimmune Polyglandular Syndrome type 2.

Rev Assoc Med Bras (1992) 2019 Dec;65(12):1434-1437

. Hospital Assistant with a Degree on Internal Medicine, Tondela-Viseu Hospital Center, Portugal.

Autoimmune polyglandular syndrome type 2 (APS 2) is defined by the presence of Addison's disease (AD) associated with autoimmune thyroid disease and/or Type 1 diabetes mellitus (T1DM). It is a rare disease, affecting about 1.4-2 cases/100,000 inhabitants. Read More

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http://dx.doi.org/10.1590/1806-9282.65.12.1434DOI Listing
December 2019

Beyond the adrenals: Organ manifestations in inherited primary adrenal insufficiency in children.

Authors:
Clemens Kamrath

Eur J Endocrinol 2020 Mar;182(3):C9-C12

Division of Pediatric Endocrinology and Diabetology Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany.

Primary adrenal insufficiency (PAI) in children is mostly due to genetic defects. The understanding of the molecular genetics of the causes of adrenal insufficiency in the pediatric population has made significant progress during the last years. It has been shown that inherited PAI can lead to certain clinical manifestations and health problems in children beyond the adrenals. Read More

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http://dx.doi.org/10.1530/EJE-19-0995DOI Listing

POEMS syndrome: a rare cause of adrenal insufficiency in a young male.

Endocrinol Diabetes Metab Case Rep 2019 Sep 17;2019. Epub 2019 Sep 17.

Departments of Endocrinology, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal.

Summary: POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein and Skin changes) is a rare multisystemic disease. Clinical presentation is variable, the only mandatory criteria being polyneuropathy and monoclonal gammapathy in association with one major and one minor criterion. Primary adrenal insufficiency is rarely reported. Read More

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http://dx.doi.org/10.1530/EDM-19-0010DOI Listing
September 2019

ELECTROCARDIOGRAM CHANGES IN ADDISON DISEASE: POTENTIAL CLINICAL MARKER FOR ADRENAL CRISIS.

AACE Clin Case Rep 2019 Sep-Oct;5(5):e307-e310. Epub 2019 Aug 28.

Objective: To present a unique phenomenon of a patient in addisonian crisis with electrocardiogram (ECG) anomalies that resolved following glucocorticoid therapy.

Methods: We present the case report followed by discussion with literature review.

Results: A 25-year-old male with Addison disease (AD) presented with a 1-week history of lightheadedness, shortness of breath, chest pain, abdominal pain, postural hypotension, and tachycardia. Read More

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http://dx.doi.org/10.4158/ACCR-2019-0239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876962PMC

Oral and nail pigmentations: a useful parallelism for the clinician.

J Dtsch Dermatol Ges 2020 01 17;18(1):7-14. Epub 2020 Jan 17.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Oral (OP) and nail (NP) pigmentations may occur simultaneously in physiological or pathological conditions, and may be a sign of underlying syndromic conditions that necessitate further investigation and treatment. Interestingly, the nail unit and oral cavity show a clinical parallelism that may help the clinician to conduct a correct examination and reach a prompt diagnosis. Both OP and NP can manifest clinically with focal or diffuse involvement and are due to external factors (exogenous pigmentation, drug-induced pigmentation) or endogenous factors (racial pigmentation, post-inflammatory pigmentation, nevi, genetic conditions and other disorders). Read More

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http://dx.doi.org/10.1111/ddg.14023DOI Listing
January 2020

COPD and asthma in patients with opioid dependency: a cross-sectional study in primary care.

NPJ Prim Care Respir Med 2020 01 14;30(1). Epub 2020 Jan 14.

School of Population Health and Environmental Sciences, King's College London, Guy's Campus, Addison House, London, SE1 1UL, UK.

Patients treated for drug addiction have high asthma and COPD prevalence rates. The relative contributions of cigarette smoking, smoking intensity and possible smoking of other substances has not been described. We aimed to describe the prevalence and determinants of asthma and COPD in patients prescribed methadone as opioid substitution therapy (OST). Read More

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http://dx.doi.org/10.1038/s41533-019-0161-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959319PMC
January 2020

Case 1-2020: An 11-Year-Old Boy with Vomiting and Weight Loss.

N Engl J Med 2020 Jan;382(2):180-189

From the Departments of Pediatrics (A.F., M.M.L., D.M.M.) and Pathology (G.E.), Massachusetts General Hospital, and the Departments of Pediatrics (A.F., M.M.L., D.M.M.) and Pathology (G.E.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1913469DOI Listing
January 2020

Potential Cardiometabolic Health Benefits of Full-Fat Dairy: The Evidence Base.

Adv Nutr 2020 May;11(3):533-547

Department of Applied Health Science, School of Public Health, Indiana University, Bloomington, IN, USA.

Since their inception in 1980, the Dietary Guidelines for Americans have promoted low- or fat-free dairy foods. Removing fat from dairy does not reduce putatively beneficial nutrients per serving, including calcium, vitamin D, and potassium. Additionally, links between saturated fat and dietary cholesterol intakes with cardiovascular disease risk have helped to sustain the view that low-fat dairy foods should be recommended. Read More

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http://dx.doi.org/10.1093/advances/nmz132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231591PMC

Blood eosinophil count, a marker of inhaled corticosteroid effectiveness in preventing COPD exacerbations in post-hoc RCT and observational studies: systematic review and meta-analysis.

Respir Res 2020 Jan 3;21(1). Epub 2020 Jan 3.

Department of Public Health and Primary Care, School of Population Health & Environmental Sciences, King's College London, 3rd floor Addison House, Guys Campus, London, SE1 1UL, UK.

Background: Blood eosinophil count has been proposed as a predictor of response to inhaled corticosteroid (ICS) in the prevention of acute exacerbations of COPD. An optimal threshold of blood eosinophil count for prescribing ICS has not been agreed. Doubt has been cast on the role by observational studies. Read More

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http://dx.doi.org/10.1186/s12931-019-1268-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942335PMC
January 2020

The color of skin: brown diseases of the skin, nails, and mucosa.

Clin Dermatol 2019 Sep - Oct;37(5):487-506. Epub 2019 Jul 23.

Department of Dermatology, Cerrahpaşa Medical Faculty, Istanbul University-Cerrahpaşa, Istanbul, Turkey.

Brown diseases comprise disorders leading to hyperpigmentation in skin and nails. Melasma is an acquired skin disorder that is characterized by brownish macules that typically occur on the face. Schamberg disease, also known as progressive pigmented purpura, is characterized by brown pigmentation with pepper spots on their edges. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.07.007DOI Listing

How can someone's entire skin change color?

Clin Case Rep 2019 Dec 24;7(12):2581-2582. Epub 2019 Oct 24.

Cancer Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran.

One of the most important differential diagnoses that not to be missed in patients with hyperpigmentation changes in the skin is Addison's. The diagnosis of the disease is relatively difficult, and its misdiagnosis leads to dangerous morbidity and even mortality. It confirms by cosyntropin test. Read More

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http://dx.doi.org/10.1002/ccr3.2505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935622PMC
December 2019