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    The Schmidt Syndrome.
    Acta Biomed 2018 Jan 16;88(4):499-501. Epub 2018 Jan 16.
    Parma University Hospital.
    Addison's disease (AD) is a rare endocrine condition related to adrenal insufficiency. Autoimmune adrenalitis is commonly associated with autoimmune diseases. Autoimmune Addison's Disease (AAD) describes Autoimmune Polyendocrine Syndrome (APS) in 60% of patients with an important immunitary pathogenesis imprinting. Read More

    Relationship between sedentary behavior and depression: A mediation analysis of influential factors across the lifespan among 42,469 people in low- and middle-income countries.
    J Affect Disord 2018 Jan 3;229:231-238. Epub 2018 Jan 3.
    Research and Development Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, Barcelona 08830, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Monforte de Lemos 3-5 Pabellón 11, Madrid 28029, Spain.
    Background: Sedentary behavior (SB) is associated with diabetes, cardiovascular disease and low mood. There is a paucity of multi-national research investigating SB and depression, particularly among low- and middle-income countries. This study investigated the association between SB and depression, and factors which influence this. Read More

    Addison disease and normocalcemic primary hyperparathyroidism in a dog with multiple endocrine neoplasia.
    Open Vet J 2017 5;7(4):332-336. Epub 2017 Dec 5.
    Cátedra de Patología, Fac. de Ciencias Veterinarias, UBA, Av. Chorroarín 280, Ciudad Autónoma de Buenos Aires, Argentina.
    A 12-year old dog with a 9-year history of primary adrenal insufficiency was referred to the service for hyporexia, muscle weakness, polyuria and polydipsia. Ultrasound examination showed an unresectable mass in the left adrenal gland, with local vascular invasion, which prompted the euthanasia of the animal. Additionally, necropsy revealed a nodular lesion in the right adrenal gland and enlargement of one of the four parathyroid glands. Read More

    Characteristics of Korean Patients with Primary Adrenal Insufficiency: A Registry-Based Nationwide Survey in Korea.
    Endocrinol Metab (Seoul) 2017 Dec;32(4):466-474
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
    Background: Primary adrenal insufficiency (PAI) is a rare, potentially life-threatening condition. There are few Korean studies on PAI, and most have had small sample sizes. We aimed to examine the etiology, clinical characteristics, treatment, and mortality of PAI in Korean patients. Read More

    Does intensive management improve remission rates in patients with intermediate rheumatoid arthritis? (the TITRATE trial): study protocol for a randomised controlled trial.
    Trials 2017 Dec 8;18(1):591. Epub 2017 Dec 8.
    Academic Department of Rheumatology, King's College London, Weston Education Centre, Cutcombe Road, Denmark Hill, London, SE5 9RJ, UK.
    Background: Uncontrolled active rheumatoid arthritis can lead to increasing disability and reduced quality of life over time. 'Treating to target' has been shown to be effective in active established disease and also in early disease. However, there is a lack of nationally agreed treatment protocols for patients with established rheumatoid arthritis who have intermediate disease activity. Read More

    Hyperkalemia and Acute Kidney Injury in an Adolescent: Thinking Outside the Box.
    Pediatr Emerg Care 2017 Dec 1. Epub 2017 Dec 1.
    Addison disease is a rare endocrine disorder, which typically presents with nonspecific symptoms including weight loss, fatigue, and nausea in conjunction with hyponatremia and hyperkalemia. This case demonstrates key diagnostic clues in evaluation of an adolescent who presented with severe hyperkalemia and acute kidney injury that was resistant to insulin, glucose, and sodium polystyrene sulfonate and was found to have primary adrenal insufficiency. Read More

    Group 6. Modalities and frequency of monitoring of patients with adrenal insufficiency. Patient education.
    Ann Endocrinol (Paris) 2017 Dec 1;78(6):544-558. Epub 2017 Dec 1.
    Service d'endocrinologie diabétologie pédiatrique, hôpital Robert-Debré, université Paris-Diderot, centre de référence des maladies endocriniennes rares de la croissance et du développement, Assistance publique-hôpitaux de Paris, 48, boulevard Sérurier, 75019 Paris, France.
    Patients with adrenal insufficiency require regular, specialised monitoring in order to optimise their replacement therapy, to detect signs of under- and over-dosage, and to examine for possible associated disorders (auto-immune disorders in the case of auto-immune primary adrenal insufficiency either isolated or as part of auto-immune polyendocrinopathy syndrome type 1; illnesses with underlying monogenic causes). The transition period between adolescence and adulthood represents an added risk of a breakdown in monitoring which requires particular attention from medical teams and coordination between adult and pediatric medical teams. It is essential to encourage patient autonomy in the management of their illness, notably their participation in treatment education programs, in particular programs that target avoidance of, or early treatment of acute adrenal insufficiency. Read More

    Group 1. Epidemiology of primary and secondary adrenal insufficiency: Prevalence and incidence, acute adrenal insufficiency, long-term morbidity and mortality.
    Ann Endocrinol (Paris) 2017 Dec 27;78(6):490-494. Epub 2017 Nov 27.
    Service des maladies endocriniennes et métaboliques, hôpital Cochin, CHU Paris Centre, 75014 Paris, France.
    The prevalence of primary adrenal insufficiency is estimated at between 82-144/million, with auto-immunity being the most common cause in adults and genetic causes, especially enzyme defects, being the most common cause in children. The prevalence of secondary adrenal deficiency is estimated to be between 150-280/million. The most frequent occurrence is believed to be corticosteroid-induced insufficiency, despite the incidence of clinically relevant deficiency after cessation of glucocorticoid treatment being widely debated. Read More

    Group 5: Acute adrenal insufficiency in adults and pediatric patients.
    Ann Endocrinol (Paris) 2017 Dec 23;78(6):535-543. Epub 2017 Nov 23.
    Service d'endocrinologie et des maladies de la reproduction, hôpital de Bicêtre, hôpitaux universitaires Paris-Sud, AP-HP, 94275 Le Kremlin-Bicêtre, France; Inserm 1185, faculté médecine Paris-Sud, université Paris-Sud, université Paris-Saclay, 94276 Le Kremlin-Bicêtre, France.

    Group 2: Adrenal insufficiency: screening methods and confirmation of diagnosis.
    Ann Endocrinol (Paris) 2017 Dec 23;78(6):495-511. Epub 2017 Nov 23.
    Service d'endocrinologie et nutrition, CHU Ambroise-Paré, AP-HP, 9, avenue Charles-de-Gaulle, Boulogne-Billancourt, France; Inserm U1173, université Versailles-Saint-Quentin, Montigny-Le-Bretonneux, France. Electronic address:
    A diagnosis of adrenal insufficiency should be suspected in the presence of a number of non-specific symptoms (fatigue, anorexia, weight loss, hypotension, hyponatremia and hyperkalemia amongst adrenal causes of insufficiency). The diagnosis should be considered in case of pituitary disease or a state of shock. Treatment should be commenced immediately without waiting for confirmation from biochemical tests, which rely on cortisol level at 8am (expected to be low) and on ACTH level (expected to be high in the case of primary adrenal insufficiency). Read More

    Residual renal and cardiovascular disease risk in conventionally-treated patients with type 2 diabetes: the potential of non-traditional biomarkers and treatments related redox metabolism.
    Minerva Med 2017 Nov 21. Epub 2017 Nov 21.
    Thomas Addison Diabetes Unit, St George's University Hospitals NHS Foundation Trust, London, UK -
    Diabetes is a leading cause of chronic kidney disease (CKD) in the developed world. Promoters of the progression of kidney disease include the traditional profile of cardiovascular risk factors. However, the development of CKD and vulnerability to end-stage renal disease (ESRD) is highly variable. Read More

    Association between prior antibiotic therapy and subsequent risk of community-acquired infections: a systematic review.
    J Antimicrob Chemother 2017 Nov 14. Epub 2017 Nov 14.
    Department of Primary Care and Public Health Sciences, King's College London, Addison House, Guy's Campus, London SE1 1UL, UK.
    Background: Antibiotic use can have negative unintended consequences including disruption of the human microbiota, which is thought to protect against pathogen overgrowth. We conducted a systematic review to assess whether there is an association between exposure to antibiotics and subsequent risk of community-acquired infections.

    Methods: We searched MEDLINE, EMBASE and Web of Science for studies published before 30 June 2017, examining the association between antibiotic use and subsequent community-acquired infection. Read More

    Sarcopenia in Peripheral Arterial Disease: Prevalence and Impact on Functional Status.
    Arch Phys Med Rehabil 2017 Nov 11. Epub 2017 Nov 11.
    Department of Veterans Affairs and Veterans Affairs Medical Center Baltimore, Geriatric Research, Education and Clinical Center (GRECC), Baltimore, MD, USA; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
    Objectives: To determine the prevalence of sarcopenia in older men with peripheral arterial disease (PAD) and to compare to a subset of the group to age, race, sex, and body mass index (BMI)-matched non-PAD control counterparts. We also sought to compare the functional status of those with PAD with and without sarcopenia.

    Design: Cohort study. Read More

    Clues for early detection of autoimmune Addison's disease - myths and realities.
    J Intern Med 2018 Feb 3;283(2):190-199. Epub 2017 Nov 3.
    Department of Clinical Medicine, University of Bergen, Bergen, Norway.
    Background: Early detection of autoimmune Addison's disease (AAD) is important as delay in diagnosis may result in a life-threatening adrenal crisis and death. The classical clinical picture of untreated AAD is well-described, but methodical investigations are scarce.

    Objective: Perform a retrospective audit of patient records with the aim of identifying biochemical markers for early diagnosis of AAD. Read More

    Primary adrenal insufficiency in adult population: a Portuguese Multicentre Study by the Adrenal Tumours Study Group.
    Endocr Connect 2017 Nov 31;6(8):935-942. Epub 2017 Oct 31.
    Department of EndocrinologyHospital de Braga, Braga, Portugal.
    Introduction: Primary adrenal insufficiency (PAI) is a rare but severe and potentially life-threatening condition. No previous studies have characterized Portuguese patients with PAI.

    Aims: To characterize the clinical presentation, diagnostic workup, treatment and follow-up of Portuguese patients with confirmed PAI. Read More

    HIV Case Management Support Service Is Associated with Improved CD4 Counts of Patients Receiving Care at the Antiretroviral Clinic of Pantang Hospital, Ghana.
    AIDS Res Treat 2017 20;2017:4697473. Epub 2017 Sep 20.
    Division of Epidemiology & Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
    Background: Factors associated with individual patient-level management of HIV have received minimal attention in sub-Saharan Africa. This study determined the association between support services and cluster of differentiation 4 (CD4) counts among HIV patients attending ART clinic in Ghana.

    Methodology: This was a cross-sectional study involving adults with HIV recruited between 1 August 2014 and 31 January 2015. Read More

    Cytokine Autoantibody Screening in the Swedish Addison Registry Identifies Patients With Undiagnosed APS1.
    J Clin Endocrinol Metab 2018 Jan;103(1):179-186
    Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.
    Context: Autoimmune polyendocrine syndrome type 1 (APS1) is a monogenic disorder that features autoimmune Addison disease as a major component. Although APS1 accounts for only a small fraction of all patients with Addison disease, early identification of these individuals is vital to prevent the potentially lethal complications of APS1.

    Objective: To determine whether available serological and genetic markers are valuable screening tools for the identification of APS1 among patients diagnosed with Addison disease. Read More

    Incidence, prevalence and seasonal onset variation of Addison's disease among persons with type 1 diabetes mellitus: nationwide, matched cohort studies.
    Eur J Endocrinol 2018 Jan 24;178(1):115-122. Epub 2017 Oct 24.
    Department of Internal Medicine and Clinical NutritionInstitute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Objectives: We determined the incidence and prevalence of Addison's disease (AD) among persons with or without type 1 diabetes mellitus (T1DM) in nationwide, matched cohort studies.

    Methods: Persons with T1DM were identified from the Swedish National Diabetes Register and each was matched for age, sex, year and county to five controls randomly selected from the general population. Persons with AD were identified from the Swedish National Inpatient Register. Read More

    A case of primary adrenal failure in the emergency department.
    Am J Emerg Med 2017 Oct 16. Epub 2017 Oct 16.
    Manchester Memorial Hospital, Department of Emergency Medicine, Manchester, CT, USA. Electronic address:
    Background: Primary adrenal failure is considered to be an extremely rare disease presenting in the ED, with an incidence reported to be as low as 50 cases per 1,000,000 persons (Klauer, 2017). I would like to present a case of a young man who presented to the ED, with what I suspected to be this rare entity.

    Case Report: A 26year old otherwise healthy male presented to our ED with complaints of weakness, nausea, vomiting, and hiccups of 1. Read More

    Cardiac tamponade in a patient with autoimmune polyglandular syndrome type 2.
    Endocrinol Diabetes Metab Case Rep 2017 13;2017. Epub 2017 Oct 13.
    1st Department of Cardiology, Hellenic Red Cross Hospital, Athens, Greece.
    We describe a case of a 40-year-old woman who was admitted to the intensive care unit with a rapid onset of dyspnea and orthopnea. She presented progressive weakness, weight loss and secondary amenorrhea during last year, while intermittent fever was present for the last two months. Initial biochemical evaluation showed anemia, hyponatremia and increased C-reactive protein levels. Read More

    A Novel Gametocyte Biomarker for Superior Molecular Detection of the Plasmodium falciparum Infectious Reservoirs.
    J Infect Dis 2017 Dec;216(10):1264-1272
    Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases.
    Background: Complete malaria eradication and optimal use of transmission-reducing interventions require knowledge of submicroscopic infectious reservoirs among asymptomatic individuals. Even submicroscopic levels of Plasmodium falciparum gametocytes can infect mosquitoes and promote onward transmission. Most efforts to identify gametocyte carriers use polymerase chain reaction amplification of the gametocyte-specific transcript Pfs25. Read More

    Prevalence and clinical features of hypoadrenocorticism in Great Pyrenees dogs in a referred population: 11 cases.
    Can Vet J 2017 Oct;58(10):1093-1099
    Department of Clinical Sciences, Université de Montréal, Faculté de médecine vétérinaire, 1500 rue des Vétérinaires, Saint Hyacinthe, Quebec J2S 7C6.
    Naturally occurring hypoadrenocorticism (Addison's disease) is uncommon, with an estimated prevalence in the canine population between 0.06% and 0.28%. Read More

    A novel data-driven workflow combining literature and electronic health records to estimate comorbidities burden for a specific disease: a case study on autoimmune comorbidities in patients with celiac disease.
    BMC Med Inform Decis Mak 2017 Sep 29;17(1):140. Epub 2017 Sep 29.
    Georges Pompidou European Hospital (HEGP), AP-HP, Paris, France.
    Background: Data collected in EHRs have been widely used to identifying specific conditions; however there is still a need for methods to define comorbidities and sources to identify comorbidities burden. We propose an approach to assess comorbidities burden for a specific disease using the literature and EHR data sources in the case of autoimmune diseases in celiac disease (CD).

    Methods: We generated a restricted set of comorbidities using the literature (via the MeSH® co-occurrence file). Read More

    Visceral Fat and Novel Biomarkers of Cardiovascular Disease in Patients With Addison's Disease: A Case-Control Study.
    J Clin Endocrinol Metab 2017 Nov;102(11):4264-4272
    Department of Endocrinology, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.
    Context: Patients with Addison's disease (AD) have increased cardiovascular mortality.

    Objective: To study visceral fat and conventional and exploratory cardiovascular risk factors in patients with AD.

    Design: A cross-sectional, single-center, case-control study. Read More

    Human Papillomavirus Status and the Risk of Cerebrovascular Events Following Radiation Therapy for Head and Neck Cancer.
    J Am Heart Assoc 2017 Aug 30;6(9). Epub 2017 Aug 30.
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Background: Radiation therapy (RT) is a standard treatment for head and neck cancer; however, it is associated with inflammation, accelerated atherosclerosis, and cerebrovascular events (CVEs; stroke or transient ischemic attack). Human papillomavirus (HPV) is found in nearly half of head and neck cancers and is associated with inflammation and atherosclerosis. Whether HPV confers an increased risk of CVEs after RT is unknown. Read More

    Physical performance and movement-evoked pain profiles in community-dwelling individuals at risk for knee osteoarthritis.
    Exp Gerontol 2017 Nov 24;98:186-191. Epub 2017 Aug 24.
    Pain Research & Intervention Center of Excellence, University of Florida, USA; Institute on Aging, University of Florida, USA; Department of Community Dentistry and Behavioral Science, College of Dentistry, University of Florida, USA.
    Background: Knee pain associated with osteoarthritis is a significant contributor to decreased physical function. Recent evidence supports the inter-individual heterogeneity associated with knee pain presentation, but whether there is similar heterogeneity in physical performance among these individuals has not been previously examined. The aim of the present study was to characterize the variability in physical performance profiles and the pain evoked by their performance (i. Read More

    Clinical relevance of the modified physical performance test versus the short physical performance battery for detecting mobility impairments in older men with peripheral arterial disease.
    Disabil Rehabil 2017 Aug 23:1-5. Epub 2017 Aug 23.
    a Department of Veterans Affairs and Veterans Affairs Medical Center Baltimore, Geriatric Research , Education and Clinical Center (GRECC) , Baltimore , MD , USA.
    Purpose: The study is to compare the Modified Physical Performance Test (MPPT) and Short Physical Performance Battery (SPPB) as metrics of mobility and function in older men with peripheral arterial disease (PAD).

    Materials And Methods: A total of 51 men (55-87 years) with PAD underwent functional testing including the SPPB, MPPT, Walking Impairment Questionnaire (WIQ), stair ascent, and 6-min walk distance. Individuals were grouped according to SPPB and MPPT scores as not limited on either, limited only on the MPPT, or limited on both. Read More

    Addison's disease concomitant with corticotropin deficiency and pituitary CRH resistance - a case report.
    Endokrynol Pol 2017 ;68(4):468-471
    Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland, Poland; Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland, Poland.
    A 36-year-old woman was found to have a low morning ACTH concentration despite a history of Addison's disease. Past medical history: At the age of 23 years the subject developed Graves's disease, which was treated with radioiodine. At about the same time, she claimed to have two episodes of pancreatitis treated with cholecystectomy. Read More

    [Recurrent anorexia and pigmentation of skin for more than two months in an infant].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Aug;19(8):926-929
    Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, Shanghai 201102, China.
    A 2-month-old boy presented with adrenal insufficiency, impaired liver function, hypertriglyceridemia, significantly elevated creatine kinase and electrolyte disturbance. Microarray comparative genomic hybridization (aCGH) analysis test showed a pathogenic 8.7 Mb deletion in the short arm of chromosome X (Xp21. Read More

    Cholestasis and Hepatic Iron Deposition in an Infant With Complex Glycerol Kinase Deficiency.
    Pediatrics 2017 Jul;140(1)
    Division of Neonatology, Department of Pediatrics, University of Florida, Gainesville, Florida.
    We present a 6-week-old male infant with persistent hyperbilirubinemia, hypertriglyceridemia, elevated creatine kinase levels, and transaminitis since the second week of life. When he developed hyperkalemia, clinical suspicion was raised for adrenal insufficiency despite hemodynamic stability. A full endocrine workup revealed nearly absent adrenocorticotropic hormone. Read More

    Unusual Onset of Celiac Disease and Addison's Disease in a 12-Year-Old Boy.
    Int J Environ Res Public Health 2017 Jul 29;14(8). Epub 2017 Jul 29.
    Paediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06123 Perugia, Italy.
    Background: Celiac disease (CD) is an autoimmune disorder deriving from an aberrant adaptive immune response against gluten-containing grains in genetically predisposed subjects. In a number of patients, CD is associated with one or more other autoimmune diseases. Primary Addison's disease (AD) and CD may co-exist, although this association is relatively uncommon in children. Read More

    Natural history of autoimmune primary ovarian insufficiency in patients with Addison's disease: from normal ovarian function to overt ovarian dysfunction.
    Eur J Endocrinol 2017 Oct 21;177(4):329-337. Epub 2017 Jul 21.
    Diabetes UnitDepartment of Medical, Surgical, Neurological, Metabolic Sciences and Aging, University of Campania 'L. Vanvitelli', Naples, Italy.
    Context: Women with autoimmune Addison's disease with normal ovulatory cycles but positive for steroid cell antibodies (StCA) have been considered at risk of premature ovarian insufficiency (POI).

    Design: Thirty-three women younger than 40 years, with subclinical-clinical autoimmune Addison's disease but with normally ovulatory menses, were followed up for 10 years to evaluate the long-term time-related variations of StCA, ovarian function and follicular reserve. All patients and 27 control women were investigated at the start and every year for the presence and titre of StCA (by indirect immunofluorescence), serum concentrations of anti-Mullerian hormone (AMH) and ovarian function at four consecutive menses every year. Read More

    Addison's Disease Caused by Tuberculosis with Atypical Hyperpigmentation and Active Pulmonary Tuberculosis.
    Intern Med 2017 15;56(14):1843-1847. Epub 2017 Jul 15.
    Department of Medical Education and General Practice, Osaka City University, Graduate School of Medicine, Japan.
    We herein report a case of Addison's disease caused by tuberculosis characterized by atypical hyperpigmentation, noted as exacerbation of the pigmentation of freckles and the occurrence of new freckles, that was diagnosed in the presence of active pulmonary tuberculosis. The clinical condition of the patient was markedly ameliorated by the administration of hydrocortisone and anti-tuberculosis agents. When exacerbation of the pigmentation of the freckles and/or the occurrence of new freckles are noted, Addison's disease should be considered as part of the differential diagnosis. Read More

    Contrast-Enhanced Ultrasound Reveals Exercise-Induced Perfusion Deficits in Claudicants.
    J Vasc Endovasc Surg 2017 6;2(1). Epub 2017 Mar 6.
    Department of Surgery, Division of Vascular Surgery, Baltimore VA Medical Center, University of Maryland School of Medicine, Baltimore, USA.
    Background: Contrast-Enhanced Ultrasonography (CEUS) is an imaging modality allowing perfusion quantification in targeted regions of interest of the lower extremity that has not been possible with color-flow imaging or with measurement of ankle brachial indices. We developed a protocol to quantify lower extremity muscle perfusion impairment in PAD patients in response to exercise.

    Methods And Findings: Thirteen patients with Rutherford Class I-III Peripheral Arterial Disease (PAD) and no prior revascularization procedures were recruited from the Baltimore Veterans Affairs Medical Center and compared with eight control patients without PAD. Read More

    Adrenal crisis in metastatic breast cancer.
    BMJ Case Rep 2017 Jul 6;2017. Epub 2017 Jul 6.
    Interne I: Internistische Onkologie, Hämatologie u. Gastroenterologie, Ordensklinikum Linz Krankenhaus d. Barmherzigen Schwestern Linz Betriebs GmbH, Linz, Austria.
    A female patient with oestrogen receptor-positive and human epidermal growth factor receptor 2 (HER2)-positive invasive lobular breast cancer presented with progressive disease on CT scan. Some days after initiation of antineoplastic chemotherapy and anti-HER2 targeted antibody therapy, the patient presented with profuse diarrhoea, neutropaenia, nausea and weakness. Although Clostridium difficile was rapidly tackled as a causative agent of gastrointestinal complaints, clinical situation did not markedly improve despite proper antimicrobial treatment. Read More

    Factors Affecting Dietary Practices in a Mississippi African American Community.
    Int J Environ Res Public Health 2017 Jul 3;14(7). Epub 2017 Jul 3.
    Center of Excellence in Minority Health and Health Disparities, School of Public Health, Jackson State University, 350 West Woodrow Wilson Drive, Suite, 2900B, Jackson, MS 39213, USA.
    This study examined the practices, personal motivation, and barriers of African American communities in Mississippi regarding their dietary practices. We selected the Metro Jackson Area comprised of Hinds, Madison and Rankin Counties because it is a combination of urban and rural communities. The sample consisted of 70 participants from seven sites. Read More

    The Serological and Biochemical Markers of Adrenal Cortex and Endocrine Pancreas Dysfunction in Patients with Hashimoto's Thyroiditis: A Hospital-based Pilot Study.
    Indian J Endocrinol Metab 2017 Jul-Aug;21(4):540-544
    Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
    Background: The prevalence of both islet cell and adrenal autoimmunity among Asian Indian hypothyroidism patients with Hashimoto's thyroiditis (HT) is lacking in literature.

    Objectives: The objective of this study was to assess the proportion of Addison's disease (AD) and type 1 diabetes mellitus (T1DM) in patients with HT.

    Materials And Methods: The patients with hypothyroidism due to HT were included in this study over 2 years. Read More

    Multifocal oral melanoacanthoma associated with Addison's disease and hyperthyroidism: a case report.
    Arch Endocrinol Metab 2017 Jul-Aug;61(4):403-407. Epub 2017 Jun 26.
    Divisão de Patologia Oral, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brasil.
    Oral melanoacanthoma is a mucocutaneous, pigmented, rare, benign, and probably reactive lesion. This paper reports for the first time in the literature a case of multifocal oral melanoacanthoma in a patient diagnosed with Addison's disease and concomitant Graves' disease with hyperthyroidism. The patient presented with oral pigmented lesions, which were hypothesized to be mucosal pigmentation associated with Addison's disease. Read More

    The Key to Adrenal Insufficiency Education: Repetition, Repetition, Repetition.
    Pediatr Endocrinol Rev 2017 Jun;14 Suppl 2(Suppl 2):448-453
    Organic Acid Research Section (OARS) of the Medical Genomics and Metabolic Genetics Branch (MGMGB) National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
    Described more than 150 years ago by Thomas Addison, adrenal gland dysfunction, while treatable, remains a clinically significant and potentially fatal disease. Vague and non-specific symptomatology can delay diagnosis of adrenal insufficiency and lead to adrenal crisis. Affected individuals may delay self-management due to knowledge deficits or lack of required therapies. Read More

    Sex differences in vascular stiffness and relationship to the risk of renal functional decline in patients with type 2 diabetes.
    Diab Vasc Dis Res 2017 Jul 9;14(4):304-309. Epub 2017 Mar 9.
    3 Population Health Research Institute, St George's, University of London, London, UK.
    Background: Recent data suggest that the higher risk of end-stage renal disease in women compared with men is associated with waist circumference. We investigated whether vascular stiffness which is linked to visceral fat accumulation is gender specific and associated with a loss in renal function.

    Methods: We studied 166 patients with type 2 diabetes at high risk of progressive renal disease. Read More

    Histopathologic Findings of Cutaneous Hyperpigmentation in Addison Disease and Immunostain of the Melanocytic Population.
    Am J Dermatopathol 2017 Dec;39(12):924-927
    Department of Dermatology, Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente, Los Angeles, CA.
    The histopathological features of cutaneous hyperpigmentation in Addison disease have very occasionally been reported, and they include acanthosis, hyperkeratosis, focal parakeratosis, spongiosis, superficial perivascular lymphocytic infiltrate, basal melanin hyperpigmentation, and superficial dermal melanophages. We present a study on 2 biopsies from the arm and the thigh in a 77-year-old woman with a long clinical history of Addison disease as well as senile purpura and alopecia of female pattern. The patient presented diffuse hyperpigmentation of the skin, more pronounced on her face, and left upper forehead. Read More

    Premature ovarian failure could be an alarming sign of polyglandular autoimmune dysfunction.
    Endocr Regul 2017 Apr;51(2):114-116
    .
    A 31-year-old lady, diagnosed to have premature ovarian failure in the gynecology clinic, was referred for endocrine assessment because of an abnormal thyroid function test. Clinical examination revealed hypotension, and fungal skin infection under her atrophic breasts. Thyroid stimulating hormone (TSH) level was very high. Read More

    Efficacy and Safety of Degludec versus Glargine in Type 2 Diabetes.
    N Engl J Med 2017 08 12;377(8):723-732. Epub 2017 Jun 12.
    From the Research Medical Center, Kansas City, MO (S.P.M.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto (B.Z.); Imperial Clinical Trials Unit, Imperial College London, London (N.R.P.); University of Washington, Seattle (S.S.E.); Medical University of Graz, Graz, Austria (T.R.P.); Florida Hospital Translational Research Institute for Metabolism and Diabetes and Sanford Burnham Prebys Medical Discovery Institute, Orlando (R.E.P.); Novo Nordisk, Søborg, Denmark (P.-M.H., M.L., K.B.-F., A.M., S.S., K.K.); and University of North Carolina School of Medicine, Chapel Hill (J.B.B.).
    Background: Degludec is an ultralong-acting, once-daily basal insulin that is approved for use in adults, adolescents, and children with diabetes. Previous open-label studies have shown lower day-to-day variability in the glucose-lowering effect and lower rates of hypoglycemia among patients who received degludec than among those who received basal insulin glargine. However, data are lacking on the cardiovascular safety of degludec. Read More

    Amyloidosis Cutis Dyschromica, a Rare Cause of Hyperpigmentation: A New Case and Literature Review.
    Pediatrics 2017 May;139(5)
    Department of General Pediatrics and Division of Pediatric Endocrinology and Diabetes, University Children's Hospital Heidelberg, Heidelberg, Germany; and.
    Amyloidosis cutis dyschromica is a rare form of primary cutaneous amyloidosis without systemic involvement and characterized by asymptomatic, progressive hyper- and hypopigmentation. We present the first case of a patient with amyloidosis cutis dyschromica diagnosed previously elsewhere as having Addison disease with generalized hyperpigmentation of the skin. This case suggests that in patients presenting with asymptomatic cutaneous dyschromia a skin biopsy for histopathological examination should be considered. Read More

    Genetic defects in pediatric-onset adrenal insufficiency in Japan.
    Eur J Endocrinol 2017 Aug 25;177(2):187-194. Epub 2017 May 25.
    Department of PediatricsKeio University School of Medicine, Tokyo, Japan
    Context: Most patients with pediatric-onset primary adrenal insufficiency (PAI), such as 21-hydroxylase deficiency, can be diagnosed by measuring the urine or serum levels of steroid metabolites. However, the etiology is often difficult to determine in a subset of patients lacking characteristic biochemical findings.

    Objective: To assess the frequency of genetic defects in Japanese children with biochemically uncharacterized PAI and characterize the phenotypes of mutation-carrying patients. Read More

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