5,427 results match your criteria Addison Disease


Low-dose desoxycorticosterone pivalate treatment of hypoadrenocorticism in dogs: A randomized controlled clinical trial.

J Vet Intern Med 2021 Jun 10. Epub 2021 Jun 10.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.

Background: Desoxycorticosterone pivalate (DOCP) is a commonly used mineralocorticoid replacement for dogs with primary hypoadrenocorticism (HA), but manufacturer-recommended dosing protocols can be cost-prohibitive. Recent reports also have raised concerns that label dose protocols could be excessive.

Objective: To investigate the relative efficacy and adverse effects of 2 DOCP dosages in dogs with primary glucocorticoid and mineralocorticoid deficient HA. Read More

View Article and Full-Text PDF

Addison's disease as a primary manifestation of extrapulmonary tuberculosis; A case report.

Indian J Tuberc 2021 Jul 6;68(3):405-407. Epub 2020 Aug 6.

Postgraduate Institute of Medicine, University of Colombo, Sri Lanka.

Tuberculosis remains an important public health problem globally. Addison's disease due to bilateral adrenal Tuberculosis as the primary manifestation of Extrapulmonary Tuberculosis is a very rare clinical entity. Previously healthy 52 years old male presented with increasing darkening of the skin, dizziness, loss of weight, loss of appetite, generalized weakness for one year and diarrhoea, vomiting for 3 months. Read More

View Article and Full-Text PDF

Dünner und dünner, dunkler und dunkler.

MMW Fortschr Med 2021 06;163(11):28-29

Facharzt für Innere Medizin, München, Deutschland.

View Article and Full-Text PDF

More than the Eye Can See: Shedding New Light on SARS-CoV-2 Lateral Flow Device-Based Immunoassays.

ACS Appl Mater Interfaces 2021 Jun 28;13(22):25694-25700. Epub 2021 May 28.

Centre for Oral, Clinical & Translational Sciences, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London SE1 9RT, United Kingdom.

Containing the global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been an unprecedented challenge due to high horizontal transmissivity and asymptomatic carriage rates. Lateral flow device (LFD) immunoassays were introduced in late 2020 to detect SARS-CoV-2 infection in asymptomatic or presymptomatic individuals rapidly. While LFD technologies have been used for over 60 years, their widespread use as a public health tool during a pandemic is unprecedented. Read More

View Article and Full-Text PDF

Addison's disease in antiphospholipid syndrome: A rare complication.

Clin Case Rep 2021 May 19;9(5):e04107. Epub 2021 May 19.

Endocrinology and Metabolism Research Center Institute of Basic and Clinical Physiology Science Kerman University of Medical Sciences Kerman Iran.

The association of APS and AI is rare, but it is very important, and in cases where there is an evidence in favor of the association of these two diseases, due to the importance of early treatment of both diseases, further evaluation is necessary. Read More

View Article and Full-Text PDF

Onset of Addison Disease appeared during the first trimester of a twin pregnancy: A case report.

Clin Case Rep 2021 May 5;9(5):e03784. Epub 2021 May 5.

Department of Medicine Section of General Medicine and Hypertension University of Verona Verona Italy.

Addison Disease is an uncommon, life-threatening condition affecting people at any age, including women during pregnancy. If left untreated, the disease can be rapidly fatal, but the prognosis is good if promptly recognized and hormones are replaced. Read More

View Article and Full-Text PDF

ABCD1 gene mutation in an Italian family with X-linkedadrenoleukodystrophy: case series.

Endocrinol Diabetes Metab Case Rep 2021 May 1;2021. Epub 2021 May 1.

Unit of Endocrinology, Department of Pediatrics, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.

Summary: Adrenoleukodystrophy is a peroxisomal X-linked recessive disease caused by mutations in the ABCD1 gene, located on the X-chromosome (Xq28). Gene mutations in patient with adrenoleukodystrophy induce metabolic alterations characterized by impaired peroxisomal beta-oxidation and accumulation of very long chain fatty acid (VLCFA) in plasma and in all tissues. Although nutritional intervention associated with a various mixture of oil prevents the accumulation of VLCFA, to date no causal treatment is available. Read More

View Article and Full-Text PDF

Overexpression of miR-7977 in CD4+ T cells is associated with multiplex autoimmunity in patients with Addison's disease.

Eur J Endocrinol 2021 May 28;185(1):145-154. Epub 2021 May 28.

Department of Endocrinology, Metabolism and Internal Medicine, Poznań University of Medical Sciences, Poznań, Poland.

Objective: Autoimmune Addison's disease (AD) results from a combination of the genetic predisposition, unclear environmental triggers and ensuing immune dysfunction. MicroRNA molecules (miRNAs) are involved in post-transcriptional regulation of numerous target genes, hence may affect the immune function and promote autoimmunity. A deregulated miRNAs profile was reported in several autoimmune conditions. Read More

View Article and Full-Text PDF

Aggregation of autoimmunity in extended families of people with autoimmune Addison's disease.

Intern Med J 2021 May 5. Epub 2021 May 5.

Department of Endocrinology, Metabolism and Internal Medicine, Poznań University of Medical Sciences, 49 Przybyszewskiego, 60-355, Poznań, Poland.

Background: Autoimmunity accounts for 90% of cases of primary adrenal insufficiency (Addison's disease, AD). Affected persons present a significant co-occurrence of autoimmune conditions, hence, clustering of autoimmunity is also predicted among their relatives.

Aims: The aim of our study was to evaluate the burden of autoimmunity in families of people with AD. Read More

View Article and Full-Text PDF

Knee pain trajectories over 18 months in non-Hispanic Black and non-Hispanic White adults with or at risk for knee osteoarthritis.

BMC Musculoskelet Disord 2021 May 5;22(1):415. Epub 2021 May 5.

Pain Research and Intervention Center of Excellence (PRICE), University of Florida, Gainesville, FL, USA.

Background: Pain is the hallmark symptom of knee osteoarthritis (OA), and varies widely across individuals. Previous research has demonstrated both fluctuating and stable pain trajectories in knee OA using various time periods. Changes in pain assessed quarterly (i. Read More

View Article and Full-Text PDF

Hyperpigmentation from Addison's Disease.

N Engl J Med 2021 May;384(18):1752

University of the Witwatersrand, Johannesburg, South Africa

View Article and Full-Text PDF

The ROX index has greater predictive validity than NEWS2 for deterioration in Covid-19.

EClinicalMedicine 2021 May 25;35:100828. Epub 2021 Apr 25.

Department of Critical Care, Guys and St Thomas NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH, UK.

Background: Patients admitted to hospital with Covid-19 are at risk of deterioration. The National Early Warning Score (NEWS2) is widely recommended, however it's validity in Covid-19 is not established and indices more specific for respiratory failure may be more appropriate. We aim to describe the physiological antecedents to deterioration, test the predictive validity of NEWS2 and compare this to the ROX index ([SpO/FiO]/respiratory rate). Read More

View Article and Full-Text PDF

Cardiovascular Toxicities of Androgen Deprivation Therapy.

Curr Treat Options Oncol 2021 04 17;22(6):47. Epub 2021 Apr 17.

Cardio-Oncology Program, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Opinion Statement: Prostate cancer is the second leading cause of cancer death in men, and cardiovascular disease is the number one cause of death in patients with prostate cancer. Androgen deprivation therapy, the cornerstone of prostate cancer treatment, has been associated with adverse cardiovascular events. Emerging data supports decreased cardiovascular risk of gonadotropin releasing hormone (GnRH) antagonists compared to agonists. Read More

View Article and Full-Text PDF

Rate of fracture in patients with glucocorticoid replacement therapy: a systematic review and meta-analysis.

Endocrine 2021 Apr 12. Epub 2021 Apr 12.

Department of Endocrinology, Royal Darwin Hospital, Darwin, NT, Australia.

Purpose: The association between glucocorticoid replacement therapy for adrenal insufficiency (AI) and osteoporosis is unclear. Fracture is a major cause of morbidity in patients with osteoporosis. This study aims to determine if patients on glucocorticoid replacement therapy for AI have an increased rate of fractures compared to the general population. Read More

View Article and Full-Text PDF

Death Due to Adrenal Crisis: Case Report and a Review of the Forensic Literature.

Am J Forensic Med Pathol 2021 Apr 7. Epub 2021 Apr 7.

From the Department of Pathology, State University of New York, Syracuse, NY.

Abstract: Adrenal crisis is a life-threatening manifestation of acute adrenal insufficiency. One of the most important underlying causes is Addison disease (primary adrenal insufficiency).A 42-year-old White woman with a medical history of Addison disease on chronic steroid therapy was admitted to the emergency department due to sustained episodes of cardiopulmonary arrest. Read More

View Article and Full-Text PDF

Identification and mapping of a novel resistance gene to the rice pathogen, Cercospora janseana.

Theor Appl Genet 2021 Apr 7. Epub 2021 Apr 7.

H. Rouse Caffey Rice Research Station, Louisiana State University Agricultural Center, 1373 Caffey Rd, Rayne, LA, 70578, USA.

Key Message: The genetic architecture of resistance to Cercospora janseana was examined, and a single resistance locus was identified. A SNP marker was identified and validated for utilization in U.S. Read More

View Article and Full-Text PDF

Therapeutic wavelengths of ultraviolet B radiation activate apoptotic, circadian rhythm, redox signalling and key canonical pathways in psoriatic epidermis.

Redox Biol 2021 May 10;41:101924. Epub 2021 Mar 10.

Institute of Translational and Clinical Medicine, Faculty of Medical Sciences, Framlington Place, Newcastle University, Newcastle Upon Tyne, UK; Department of Dermatology, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK. Electronic address:

Ultraviolet B radiation (UVB) exerts pleiotropic effects on human skin. DNA damage response and repair pathways are activated by UVB; if damage cannot be repaired, apoptosis ensues. Although cumulative UVB exposure predisposes to skin cancer, UVB phototherapy is widely used as an effective treatment for psoriasis. Read More

View Article and Full-Text PDF

The Role of Oat Nutrients in the Immune System: A Narrative Review.

Nutrients 2021 Mar 24;13(4). Epub 2021 Mar 24.

Quaker Oats Center of Excellence, PepsiCo Health & Nutrition Sciences, Barrington, IL 60010, USA.

Optimal nutrition is the foundation for the development and maintenance of a healthy immune system. An optimal supply of nutrients is required for biosynthesis of immune factors and immune cell proliferation. Nutrient deficiency/inadequacy and hidden hunger, which manifests as depleted nutrients reserves, increase the risk of infectious diseases and aggravate disease severity. Read More

View Article and Full-Text PDF

Endocrine complications of immunotherapies: a review.

Clin Med (Lond) 2021 03;21(2):e212-e222

University Hospital of Wales, Cardiff, UK

Use of immune checkpoint inhibitors in cancer treatment has increased vastly over the past decade, as both single and combination agent therapies. While having a positive impact on survival rates, adverse effects have been noted, with endocrine effects in around 10% of patients. Thyroid disease and hypophysitis are the most commonly encountered, with diabetes mellitus and primary adrenal insufficiency also reported, as well as more rare endocrinopathies. Read More

View Article and Full-Text PDF

Addison's disease associated with hypokalemia: a case report.

J Med Case Rep 2021 Mar 25;15(1):131. Epub 2021 Mar 25.

Division of Endocrinology, Department of Medicine, Faculty of Health Sciences, Groote Schuur Hospital and University of Cape Town, Private Bag X3, J47-85 Old Main Building, Observatory, Cape Town, 7935, South Africa.

Background: Primary adrenal insufficiency (Addison's disease) is a rare medical condition usually associated with hyperkalemia or normokalemia. We report a rare case of Addison's disease, coexisting with hypokalemia, requiring treatment.

Case Presentation: In this case, a 42-year-old man was admitted to the intensive care unit with a history of loss of consciousness and severe hypoglycemia. Read More

View Article and Full-Text PDF

Addison's Disease: A Diagnosis Easy to Overlook.

Cureus 2021 Feb 15;13(2):e13364. Epub 2021 Feb 15.

Endocrinology, Hospital de Braga, Braga, PRT.

Addison's disease is a rare and potentially life-threatening clinical condition that often presents with an insidious onset of nonspecific symptoms and signs, frequently resulting in a significant delay in diagnosis. Clinical presentation usually includes fatigue and electrolyte imbalance disorders such as hyponatremia. However, specific diagnostic features, such as hyperpigmentation, should raise clinical suspicion. Read More

View Article and Full-Text PDF
February 2021

Life expectancy inequalities in Wales before COVID-19: an exploration of current contributions by age and cause of death and changes between 2002 and 2018.

Public Health 2021 Apr 15;193:48-56. Epub 2021 Mar 15.

Division of Population Medicine, School of Medicine, Cardiff University, Division of Population Medicine, School of Medicine, Cardiff University, UHW Main Building, Heath Park, Cardiff, CF14 4XN, UK.

Objectives: The COVID-19 pandemic in Wales and the UK has highlighted significant and historic inequalities in health between social groups. To better understand the composition of these inequalities and inform planning after the pandemic, we undertook a decomposition of life expectancy inequalities between the most and least deprived quintiles for men and women by age and cause of death and explored trends between 2002 and 2018.

Study Design: Statistical decomposition of life expectancy inequalities by age and cause of death using routine population mortality datasets. Read More

View Article and Full-Text PDF

Autoimmune Addison's Disease as Part of the Autoimmune Polyglandular Syndrome Type 1: Historical Overview and Current Evidence.

Front Immunol 2021 26;12:606860. Epub 2021 Feb 26.

Section of Internal Medicine and Endocrinological and Metabolic Sciences, Department of Medicine, University of Perugia, Perugia, Italy.

The autoimmune polyglandular syndrome type 1 (APS1) is caused by pathogenic variants of the autoimmune regulator () gene, located in the chromosomal region 21q22.3. The related protein, AIRE, enhances thymic self-representation and immune self-tolerance by localization to chromatin and anchorage to multimolecular complexes involved in the initiation and post-initiation events of tissue-specific antigen-encoding gene transcription. Read More

View Article and Full-Text PDF
February 2021

Reversible cerebellar ataxia and bipolar disorder secondary to tuberculous adrenalitis.

Int J Mycobacteriol 2021 Jan-Mar;10(1):79-81

Department of General Medicine, MES Medical College, Perinthalmanna, Kerala, India.

Addison's disease is primary adrenal insufficiency which is most commonly due to an autoimmune disease. Patients usually presents with fatigue, anorexia, gastrointestinal complaints, salt craving, and orthostatic hypotension. Rare manifestations during presentation can result in diagnostic dilemma. Read More

View Article and Full-Text PDF

Primary Ovarian Insufficiency in Women With Addison's Disease.

J Clin Endocrinol Metab 2021 Jun;106(7):e2656-e2663

Department of Clinical Science, University of Bergen, Bergen, Norway.

Context: Primary ovarian insufficiency (POI) is defined by menopause before 40 years of age. POI prevalence is higher among women with autoimmune Addison's disease (AAD) than in the general population, but their clinical characteristics are insufficiently studied.

Objective: To assess the prevalence of POI in a large cohort of women with AAD and describe clinical, immunological, and genetic characteristics. Read More

View Article and Full-Text PDF

Addison's disease with primary hypothyroidism in a case of visceral leishmaniasis and HIV coinfection.

BMJ Case Rep 2021 Mar 5;14(3). Epub 2021 Mar 5.

Department of Endocrinology and Medicine, Pandit Bhagwat Dayal Sharma Postgraduate Institute of Medical Sciences, Rohtak, India

A 41-year-old man presented with vomiting and loose stools. He had a history of long-term intermittent fever, generalised skin hyperpigmentation, dragging sensation in the left hypochondrium and unintentional weight loss. He was receiving combination antiretroviral therapy since 2010 for HIV infection. Read More

View Article and Full-Text PDF

Cotrimoxazole-induced hyperkalaemia in a patient with known hypoaldosteronism.

BMJ Case Rep 2021 Mar 4;14(3). Epub 2021 Mar 4.

Department of Diabetes and Endocrinology, Mater Dei Hospital, Msida, Malta.

A70-year-old man, with established hypoadrenalism due to a previous bilateral adrenalectomy, was admitted with recurrent episodes of postural dizziness and presyncope. He had been discharged from hospital 3 weeks earlier on a 1-month course of cotrimoxazole following a diagnosis of prostatitis. His electrolytes on admission showed new onset hyponatraemia and hyperkalaemia. Read More

View Article and Full-Text PDF

Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19.

Sci Immunol 2021 03;6(57)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present with Multisystem Inflammatory Syndrome in Children (MIS-C) that can lead to vascular complications and shock, but rarely death. The immune features of MIS-C compared to pediatric COVID-19 or adult disease remain poorly understood. Read More

View Article and Full-Text PDF

Venoarterial extracorporeal membrane oxygenation as bridge to effective treatment in a 19-year-old woman with acute adrenal crisis: a case report.

Eur Heart J Case Rep 2021 Feb 20;5(2):ytab031. Epub 2021 Feb 20.

Intensive Care Unit, Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Marchioninistraße 15, 81377 Munich, Germany.

Background: Adrenal crisis is an acute life-threatening exacerbation of the Addison's disease or primary adrenal insufficiency (PAI) and is associated with a high mortality rate. It can be the first manifestation of adrenal insufficiency and is caused by a critical lack of glucocorticoids.

Case Summary: Here, we report the case of a 19-year-old woman presenting to the emergency room with unspecific symptoms, i. Read More

View Article and Full-Text PDF
February 2021