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    1 OF 97

    A case of adrenoleukodystrophy presenting with manic symptoms in a patient on steroids for Addison's disease.
    Indian J Psychiatry 2016 Oct-Dec;58(4):467-470
    Department of Psychiatry, Government Medical College, Thrissur, Kerala, India.
    Adrenoleukodystrophy (ALD) is an X-linked disorder with diverse clinical presentations. A 30-year-old male, previously diagnosed with Addison's disease, on steroid supplementation for 18 years, presented to us with manic symptoms for 4 years. He was found to have white matter hypodensities in computed tomography head and had white matter signal changes in magnetic resonance imaging, and therefore a diagnosis of ALD was made. Read More

    Clinical implications for biochemical diagnostic thresholds of adrenal sufficiency using a highly specific cortisol immunoassay.
    Clin Biochem 2017 Feb 10. Epub 2017 Feb 10.
    Department of Pathology and Laboratory Medicine, University of Calgary, Calgary Laboratory Services, Canada.
    Objectives: Recent guidelines recommend a diagnosis of adrenal insufficiency when a stimulated peak cortisol level falls below 500nmol/L. This may not be valid using a highly specific cortisol immunoassay or liquid chromatography-mass spectroscopy (LCMS/MS). We sought to determine the diagnostic threshold for adrenal insufficiency using a new and widely available, highly specific cortisol immunoassay. Read More

    Paternal Low Protein Diet Programs Preimplantation Embryo Gene Expression, Fetal Growth and Skeletal Development in Mice.
    Biochim Biophys Acta 2017 Feb 8. Epub 2017 Feb 8.
    School of Engineering and Applied Science and Aston Research Centre for Healthy Ageing, Aston University, Birmingham, B4 7ET, United Kingdom.
    Defining the mechanisms underlying the programming of early life growth is fundamental for improving adult health and wellbeing. While the association between maternal diet, offspring growth and adult disease risk is well-established, the effect of father's diet on offspring development are largely unknown. Therefore, we fed male mice an imbalanced low protein diet (LPD) to determine the impact on post-fertilisation development and fetal growth. Read More

    Topical treatments for blepharokeratoconjunctivitis in children.
    Cochrane Database Syst Rev 2017 Feb 7;2:CD011965. Epub 2017 Feb 7.
    NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, 162 City Road, London, UK, EC1V 2PD.
    Background: Blepharokeratoconjunctivitis (BKC) is a type of inflammation of the surface of the eye and eyelids that involves changes of the eyelids, dysfunction of the meibomian glands, and inflammation of the conjunctiva and cornea. Chronic inflammation of the cornea can lead to scarring, vascularisation and opacity. BKC in children can cause significant symptoms including irritation, watering, photophobia and loss of vision from corneal opacity, refractive error or amblyopia. Read More

    Pernicious anemia: Fundamental and practical aspects in diagnosis.
    Cardiovasc Hematol Agents Med Chem 2017 Feb 3. Epub 2017 Feb 3.
    The University of Texas M.D. Anderson Cancer Center - Thrombosis & Benign Hematology Houston, TX,. United States.
    Pernicious anemia (PA), the most common cause of cobalamin deficiency anemia worldwide, is an autoimmune disease of multifactorial etiologies involving complex environmental and immunological factors. Although it was first reported by Addison in 1849 with subsequent advances in understanding of pathogenesis and molecular biology, diagnosis of pernicious anemia is still challenging for clinicians because of its complexity and diverse clinical presentations. Herein, we provide an overview of PA, mainly focusing on its scientific and practical aspects in diagnosis. Read More

    Cardiac Manifestations of Adrenal Insufficiency.
    Rev Cardiovasc Med 2016 ;17(3-4):131-136
    Division of Cardiovascular Diseases, Carilion Clinic and Virginia Tech Carilion School of Medicine, Roanoke, VA.
    It is estimated that the prevalence of primary adrenal insufficiency (Addison disease) is 1 in 10,000 people. There are multiple case reports and several studies that suggest a correlation between Addison disease and abnormalities of cardiac function. The pathophysiology of cardiac abnormalities in this condition is incompletely understood. Read More

    An Addison disease revealed with a serious hyponatremia.
    Ann Biol Clin (Paris) 2017 Feb;75(1):87-91
    Laboratoire.
    We present the case of an Addison's disease revealed by a serious hyponatremia. The serum concentration of ACTH and 21-hydroxylase antibodies were increased and lead to the diagnosis. The cortisol blood level was lowered but required to take into account the stress induced by the hospitalisation of the patient. Read More

    Clinical features and practice patterns of treatment for adrenal crisis: a nationwide cross-sectional study in Japan.
    Eur J Endocrinol 2017 Mar;176(3):329-337
    Department of General MedicineNational Defense Medical College, Tokorozawa, Saitama, Japan.
    Context: Adrenal crisis is an endocrine emergency that requires prompt diagnosis and treatment. However, the clinical features and practice patterns of treatment for adrenal crisis are not completely understood.

    Objective: To investigate patient characteristics, comorbidities and treatments of adrenal crisis. Read More

    A phase 2 trial exploring the clinical and correlative effects of combining doxycycline with bone-targeted therapy in patients with metastatic breast cancer.
    J Bone Oncol 2016 Nov 1;5(4):173-179. Epub 2016 Jul 1.
    Ottawa Hospital Research Institute and University of Ottawa, Department of Medicine, Ottawa, Ontario, Canada; Division of Medical Oncology, The Ottawa Hospital Cancer Centre and Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
    Background: Bone-targeting agents (BTAs), such as bisphosphonates and denosumab, have demonstrated no discernable effects on tumour response or disease free/overall survival in patients with bone metastases from breast cancer. Doxycycline is both osteotropic and has anti-cancer effects. When combined with zoledronate in animal models, doxycycline showed significantly increased inhibition of tumour burden and increased bone formation. Read More

    Creating a driving profile for older adults using GPS devices and naturalistic driving methodology.
    F1000Res 2016 26;5:2376. Epub 2016 Sep 26.
    Charles F. and Joanne Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63130, USA.
    Background/Objectives: Road tests and driving simulators are most commonly used in research studies and clinical evaluations of older drivers. Our objective was to describe the process and associated challenges in adapting an existing, commercial, off-the-shelf (COTS), in-vehicle device for naturalistic, longitudinal research to better understand daily driving behavior in older drivers. Design: The Azuga G2 Tracking Device (TM) was installed in each participant's vehicle, and we collected data over 5 months (speed, latitude/longitude) every 30-seconds when the vehicle was driven. Read More

    Maternal and neonatal outcomes of pregnancies in women with Addison's disease: a population-based cohort study on 7.7 million births.
    BJOG 2016 Dec 15. Epub 2016 Dec 15.
    Department of Obstetrics and Gynaecology, Jewish General Hospital, Montreal, QC, Canada.
    Objective: To assess if pregnancies among women with Addison's disease (AD) are at higher risk of adverse maternal and neonatal outcomes.

    Design: Population-based retrospective cohort study.

    Setting/population: All births in the United States' Healthcare Cost and Utilization Project-Nationwide Inpatient Sample from 2003 to 2011. Read More

    Outcomes following operative vs. non-operative management of blunt traumatic pancreatic injuries: a retrospective multi-institutional study.
    Burns Trauma 2016 9;4:39. Epub 2016 Dec 9.
    Department of Surgery, Hofstra-Northwell School of Medicine, Hempstead, NY USA ; Pancreas Disease Center, Northwell Health, Manhasset, NY USA ; Northwell Health, 900 Northern Boulevard, Suite 150, Great Neck, NY 11020 USA.
    Background: Traumatic pancreatic injuries are rare, and guidelines specifying management are controversial and difficult to apply in the acute clinical setting. Due to sparse data on these injuries, we carried out a retrospective review to determine outcomes following surgical or non-surgical management of traumatic pancreatic injuries. We hypothesize a higher morbidity and mortality rate in patients treated surgically when compared to patients treated non-surgically. Read More

    Mortality in patients with diabetes mellitus and Addison's disease: a nationwide, matched, observational cohort study.
    Eur J Endocrinol 2017 Jan;176(1):31-39
    Department of Internal Medicine and Clinical NutritionInstitute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Objective: Our hypothesis was that patients with diabetes mellitus obtain an additional risk of death if they develop Addison's disease (AD).

    Design And Methods: Nationwide, matched, observational cohort study cross-referencing the Swedish National Diabetes Register with Inpatient, Cancer and Cause of Death Registers in patients with diabetes (type 1 and 2) and AD and matched controls with diabetes. Clinical characteristics at baseline, overall, and cause-specific mortality were assessed. Read More

    Polyglandular Autoimmune Syndrome in pregnancy: case report.
    Ital J Gynaecol Obstet 2016 Sep;28(4):35-40
    Division of Gynecology and Obstetrics, Maternal and Child Department, Cannizzaro Hospital, Catania, Italy.
    Type III Polyglandular Autoimmune Syndrome is a multiple endocrine disorders disease determined by autoimmunity; it can be diagnosed if a patient is affected by Type 1 Diabetes Mellitus and another autoimmune disease, except Addison Disease, for example Autoimmune Hashimoto Thyroiditis or Celiac Disease. R.D. Read More

    Long term condition morbidity in English general practice: a cross-sectional study using three composite morbidity measures.
    BMC Fam Pract 2016 Nov 29;17(1):166. Epub 2016 Nov 29.
    Division of Health and Social Care Research, Department of Primary Care and Public Health Sciences, King's College London, Addison House, Guy's Campus, London, SE1 1UL, UK.
    Background: The burden of morbidity represented by patients with long term conditions (LTCs) varies substantially between general practices. This study aimed to determine the characteristics of general practices with high morbidity burden.

    Method: Retrospective cross-sectional study; general practices in England, 2014/15. Read More

    Clinical and immunological characteristics of Autoimmune Addison's disease: a nationwide Swedish multicenter study.
    J Clin Endocrinol Metab 2016 Nov 21:jc20162522. Epub 2016 Nov 21.
    3 Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
    Context: Studies on clinical and immunological features of Autoimmune Addison's disease (AAD) are needed to understand the disease burden and increased mortality.

    Objective: To provide upgraded data on autoimmune comorbidities, replacement therapy, autoantibody profiles and cardiovascular risk factors.

    Design, Setting And Participants: Cross sectional, population-based study. Read More

    MANAGEMENT OF ENDOCRINE DISEASE: Regenerative therapies in autoimmune Addison's disease.
    Eur J Endocrinol 2017 Mar 3;176(3):R123-R135. Epub 2016 Nov 3.
    Institute of Genetic MedicineInternational Centre for Life, Centre Parkway, Newcastle upon Tyne, UK.
    The treatment for autoimmune Addison's disease (AAD) has remained virtually unchanged in the last 60 years. Most patients have symptoms that are relatively well controlled with exogenous steroid replacement, but there may be persistent symptoms, recurrent adrenal crisis and poor quality of life, despite good compliance with optimal current treatments. Treatment with conventional exogenous steroid therapy is also associated with premature mortality, increased cardiovascular risk and complications related to excessive steroid replacement. Read More

    Extended exome sequencing identifies BACH2 as a novel major risk locus for Addison's disease.
    J Intern Med 2016 Dec 2;280(6):595-608. Epub 2016 Nov 2.
    Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
    Background: Autoimmune disease is one of the leading causes of morbidity and mortality worldwide. In Addison's disease, the adrenal glands are targeted by destructive autoimmunity. Despite being the most common cause of primary adrenal failure, little is known about its aetiology. Read More

    Development and interval testing of a naturalistic driving methodology to evaluate driving behavior in clinical research.
    F1000Res 2016 15;5:1716. Epub 2016 Jul 15.
    Charles F. and Joanne Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St. Louis, USA.
    Background: The number of older adults in the United States will double by 2056. Additionally, the number of licensed drivers will increase along with extended driving-life expectancy. Motor vehicle crashes are a leading cause of injury and death in older adults. Read More

    Trans fatty acids and cholesterol levels: An evidence map of the available science.
    Food Chem Toxicol 2016 Dec 7;98(Pt B):269-281. Epub 2016 Jul 7.
    U.S. Department of Agriculture, Beltsville Human Nutrition Research Center, USA.
    High intakes of industrial trans fatty acids (iTFA) increase circulating low density lipoprotein cholesterol (LDL-C) levels, which has implicated iTFA in coronary heart disease (CHD) risk. Published data on iTFA and LDL-C, however, represent higher intake levels than the U.S. Read More

    Delayed diagnosis with autoimmune polyglandular syndrome type 2 causing acute adrenal crisis: A case report.
    Medicine (Baltimore) 2016 Oct;95(42):e5062
    Key laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
    Background: Autoimmune polyglandular syndrome type 2 (APS-2), also known as Schmidt's syndrome, is an uncommon disorder characterized by the coexistence of Addison's disease with thyroid autoimmune disease and/or type 1 diabetes mellitus. Addison's disease as the obligatory component is potentially life-threatening. Unfortunately, the delayed diagnosis of Addison's disease is common owing to its rarity and the nonspecific clinical manifestation. Read More

    Paul Ehrlich and the Early History of Granulocytes.
    Microbiol Spectr 2016 Aug;4(4)
    Paul Ehrlich's techniques, published between 1879 and 1880, for staining blood films using coal tar dyes, and his method of differential blood cell counting, ended years of speculation regarding the classification of white cells. Acidic and basic dyes had allowed him to recognize eosinophil and basophil granules, respectively, work that was a direct continuation of his discovery of the tissue mast cell described in his doctoral thesis. Ehrlich went on to develop neutral dyes that identified epsilon granules in neutrophils ("cells with polymorphous nuclei"). Read More

    Evaluation of Basal Serum or Plasma Cortisol Concentrations for the Diagnosis of Hypoadrenocorticism in Dogs.
    J Vet Intern Med 2016 Nov 7;30(6):1798-1805. Epub 2016 Oct 7.
    and the Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI.
    Background: Previous studies that included limited numbers of affected dogs have suggested basal cortisol concentrations ≤55 nmol/L (2 μg/dL) are sensitive, but nonspecific, for a diagnosis of hypoadrenocorticism. A detailed assessment of the diagnostic utility of basal cortisol concentrations is warranted.

    Hypothesis/objectives: To evaluate the utility of basal cortisol concentrations for the diagnosis of hypoadrenocorticism in a large number of dogs, including those with and without serum electrolyte abnormalities. Read More

    Corn oil intake favorably impacts lipoprotein cholesterol, apolipoprotein and lipoprotein particle levels compared with extra-virgin olive oil.
    Eur J Clin Nutr 2017 Jan 28;71(1):33-38. Epub 2016 Sep 28.
    Midwest Biomedical - Center for Metabolic and Cardiovascular Research, Glen Ellyn, IL, USA.
    Background: Corn oil (CO) and extra-virgin olive oil (EVOO) are rich sources of unsaturated fatty acids (UFA), but UFA profiles differ among oils, which may affect lipoprotein levels.

    Objectives: The objective of this study was to assess the effects of CO versus EVOO intake on fasting lipoprotein and subfraction cholesterol levels, apolipoprotein (apo) A1, apo B, and low-density lipoprotein particle concentrations in men and women.

    Subjects/methods: As part of a weight maintenance diet, men and women were provided with food items prepared with 54 g per day of CO or EVOO (21-day treatment, 21-day washout) in a randomized, double-blind, controlled-feeding, crossover trial. Read More

    Addison Disease and Discoid Lupus Erythematosus: A Rare Association of Polyglandular Autoimmune Syndrome Type II.
    J Clin Rheumatol 2016 Oct;22(7):382-3
    From the *Corporal Michael J. Crescenz Medical Center; †Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania; and ‡Department of Dermatology, Thomas Jefferson University Sidney Kimmel School of Medicine, Philadelphia, PA.

    Connecting the Dots: A Comparative Global Multi-Institutional Study of Prohibitive Factors Affecting Cancer Pain Management.
    Pain Med 2016 Sep 20. Epub 2016 Sep 20.
    Department of Anesthesiology & Critical Care Medicine, Division of Pain Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Objective: [Formula: see text]The goal of this study was to elucidate the attitudes, beliefs, and barriers interfering with cancer pain management, the degree of barrier interference with trainees' care of patients, and the relationships among prohibitive factors to pain management for physicians in a low-middle-income countries (LMICs) vs high-income countries (HICs).

    Design And Setting:  A multi-institutional cross-sectional survey of physicians in specialties with a focus in pain management training was performed. All surveys were completed anonymously from July 1, 2015, to November 30, 2015. Read More

    Changes in cardiovascular disease risk and behavioural risk factors before the introduction of a health check programme in England.
    Prev Med 2016 Oct 16;91:158-163. Epub 2016 Aug 16.
    Department of Primary Care and Public Health Sciences, King's College London, Addison House, Guy's Campus, London SE1 1UL, United Kingdom.
    A population-based programme of health checks was introduced for adults in England in 2011 for the primary prevention of cardiovascular diseases (CVD) and risk factors management. The aim was to evaluate changes in cardiovascular risk and behavioural risk factors in a health check eligible population in England from 1994 to 2013, by using repeated cross-sectional design using seven surveys of the Health Survey for England. Measures included traditional CVD risk factors and behavioural risk factors. Read More

    An ABCD1 Mutation (c.253dupC) Caused Diverse Phenotypes of Adrenoleukodystrophy in an Iranian Consanguineous Pedigree.
    J Mol Genet Med 2016 Jun 19;10(2). Epub 2016 Jun 19.
    Department of Medical Genetics and Molecular Biology, Faculty of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran; NIH Undiagnosed Diseases Program, National Human Genome Research Institute (NHGRI), National Institutes of Health, Bethesda, Maryland, USA.
    Objectives: Current study was the first to report a consanguineous Iranian pedigree with ABCD1 mutation.

    Methods: Targeted molecular analysis was initially performed in three affected individuals in one family suspected to have X-ALD due to chronic progressive spasticity. Upon confirmation of genetic diagnosis, further neurologic and genetic evaluation of all family members was done. Read More

    Creating the Future of Evidence-Based Nutrition Recommendations: Case Studies from Lipid Research.
    Adv Nutr 2016 Jul 15;7(4):747-55. Epub 2016 Jul 15.
    School of Professional Studies, Northwestern University, Evanston, IL and North American Branch of the International Life Sciences Institute, Washington, DC
    Strategic translational research is designed to address research gaps that answer specific guidance questions. It provides translational value with respect to nutrition guidance and regulatory and public policy. The relevance and the quality of evidence both matter in translational research. Read More

    Estrogen, progesterone, and HER2/neu receptor discordance between primary and metastatic breast tumours-a review.
    Cancer Metastasis Rev 2016 Sep;35(3):427-37
    Division of Surgical Oncology, University of Ottawa, Ottawa, Canada.
    Discordance in estrogen (ER), progesterone (PR), and HER2/neu status between primary breast tumours and metastatic disease is well recognized. In this review, we highlight how receptor discordance between primary tumours and paired metastasis can help elucidate the mechanism of metastasis but can also effect patient management and the design of future trials. Discordance rates and ranges were available from 47 studies (3384 matched primary and metastatic pairs) reporting ER, PR, and HER2/neu expression for both primary and metastatic sites. Read More

    Comparing the case mix and survival of women receiving breast cancer care from one private provider with other London women with breast cancer: pilot data exchange and analyses.
    BMC Cancer 2016 Jul 7;16:421. Epub 2016 Jul 7.
    Public Health England, Knowledge and Intelligence (London), 2nd Floor, Skipton House, 80 London Road, London, SE1 6HL, UK.
    Background: Data from providers of private cancer care are not yet formally included in English cancer registration data. This study aimed to test the exchange of breast cancer data from one Hospital Corporation of America International (HCAI) hospital in London with the cancer registration system and assess the suitability of these data for comparative analyses of case mix and adjusted survival.

    Methods: Data on 199 London women receiving 'only HCAI care', 278 women receiving 'some HCAI care' (HCAI and other services), and 31,234 other London women diagnosed between 2005 and 2011 could be identified and compared. Read More

    Changes in Function After a 6-Month Walking Intervention in Patients With Intermittent Claudication Who Are Obese or Nonobese.
    J Geriatr Phys Ther 2016 Jun 23. Epub 2016 Jun 23.
    1Department of Medicine, Division of Gerontology, University of Maryland, Baltimore. 2Department of Veterans Affairs and Veterans Affairs Medical Center, Geriatric Research, Education and Clinical Centers, Baltimore, Maryland. 3Department of Surgery, Division of Vascular Surgery, University of Maryland, Baltimore. 4Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.
    Background And Purpose: Both obesity and peripheral artery disease (PAD) limit function and may work additively to reduce mobility. The purpose of this study was to compare the effects of a 6-month, center-based walking program on mobility function between adults who are weight-stable obese and nonobese with PAD.

    Methods: This is a secondary data analysis of 2 combined studies taken from previous work. Read More

    Experimental pain phenotyping in community-dwelling individuals with knee osteoarthritis.
    Pain 2016 Sep;157(9):2104-14
    aPain Research and Intervention Center of Excellence (PRICE), University of Florida, Gainesville, FL, USA bDepartment of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, USA Departments of cBiobehavioral Nursing Science and dAging and Geriatric Research, University of Florida, Gainesville, FL, USA eDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA fDivision of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA gDepartment of Medicine, University of Florida, Gainesville, FL, USA Departments of hBiostatistics and iMedicine and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
    Pain among individuals with knee osteoarthritis (OA) is associated with significant disability in older adults, and recent evidence demonstrates enhanced experimental pain sensitivity. Although previous research showed considerable heterogeneity in the OA clinical pain presentation, less is known regarding the variability in responses to experimental pain. The present study included individuals with knee OA (n = 292) who participated in the Understanding Pain and Limitations in Osteoarthritic Disease study and completed demographic and psychological questionnaires followed by a multimodal quantitative sensory testing (QST) session. Read More

    Skin disease in pregnancy: The approach of the obstetric medicine physician.
    Clin Dermatol 2016 May-Jun;34(3):320-6. Epub 2016 Feb 10.
    Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address:
    This review presents the approach of the obstetric medicine physician to skin disease in pregnancy. It elaborates on common skin-related problems during gestation, such as pruritus, with or without eruption, and drug eruptions. An algorithmic approach to the differential diagnosis of pruritus in pregnancy is outlined. Read More

    Lymphovascular space invasion in uterine corpus cancer: What is its prognostic significance in the absence of lymph node metastases?
    Gynecol Oncol 2016 Aug 8;142(2):278-82. Epub 2016 Jun 8.
    Division of Gynecologic Oncology, Medical University of South Carolina, Charleston, SC, USA; Hollings Cancer Center, Charleston, SC, USA.
    Objective: Lymphovascular space invasion (LVSI) is a poor prognostic indicator in uterine cancer, primarily due to its association with lymph node metastases. We sought to determine if LVSI provides any prognostic information for uterine cancer subjects in the absence of nodal disease.

    Methods: A retrospective review was performed using a database of women treated for uterine cancer at MUSC from 2005 to 2012. Read More

    Endocrine Dysfunction in X-Linked Adrenoleukodystrophy.
    Endocrinol Metab Clin North Am 2016 Jun 13;45(2):295-309. Epub 2016 Apr 13.
    Division of Pediatric Endocrinology and Diabetes, Kravis Children's Hospital, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1616, New York, NY 10029, USA. Electronic address:
    X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1 gene and leads to an elevation of very-long-chain fatty acids (VLCFA). The accumulation of the VLCFA and the associated oxidative stress can present with a spectrum of significant neurologic disease, adrenal insufficiency, and testicular dysfunction in males with ABCD1 gene mutations. Much of the published literature for X-ALD has focused on the associated devastating progressive neurologic conditions. Read More

    Effect of Intragastric Balloons on Liver Enzymes: A Systematic Review and Meta-Analysis.
    Dig Dis Sci 2016 Sep 20;61(9):2477-87. Epub 2016 May 20.
    Yale School of Medicine and VA Connecticut Healthcare System, PO Box 208019, New Haven, CT, 06520, USA.
    Background: Intragastric balloons (IGBs) are safe and effective in inducing weight loss in obese patients. The objective of this study was to review and analyze the available data of the effect of IGB on markers of nonalcoholic fatty liver disease (NAFLD) and liver enzymes.

    Methods: Searches were performed of MEDLINE and Embase databases from inception through January 2016. Read More

    Outcomes in patients with chronic kidney disease not on dialysis receiving extended dosing regimens of darbepoetin alfa: long-term results of the EXTEND observational cohort study.
    Nephrol Dial Transplant 2016 Dec 15;31(12):2073-2085. Epub 2016 Apr 15.
    Oxford Kidney Unit, Churchill Hospital, Oxford, UK.
    Background: Extended dosing of the erythropoiesis-stimulating agent (ESA) darbepoetin alfa (DA) once biweekly or monthly reduces anaemia treatment burden. This observational study assessed outcomes and dosing patterns in patients with chronic kidney disease not on dialysis (CKD-NoD) commencing extended dosing of DA.

    Methods: Adult CKD-NoD patients starting extended dosing of DA in Europe or Australia in June 2006 or later were followed up until December 2012. Read More

    First presentation of Addison's disease as hyperkalaemia in acute kidney injury.
    BMJ Case Rep 2016 May 11;2016. Epub 2016 May 11.
    Department of Acute Medicine, Hillingdon Hospital, Uxbridge, UK Imperial College London, London, UK.
    Addison's disease is a rare endocrine disorder that frequently presents with non-specific symptoms, but may deteriorate rapidly into life-threatening Addisonian crisis if left untreated. Diagnosis can be difficult in patients without a suggestive medical history. We describe a case of a 37-year-old man who was admitted with acute kidney injury and hyperkalaemia, resistant to treatment with insulin/dextrose and calcium gluconate. Read More

    The Natural History of Subclinical Hyperthyroidism in Graves' Disease: The Rule of Thirds.
    Thyroid 2016 Jun 10;26(6):765-9. Epub 2016 May 10.
    1 Department of Endocrinology, Queen Elizabeth Hospital , Gateshead, United Kingdom .
    Background: There is little information regarding the natural history of subclinical hyperthyroidism (SH) due to Graves' disease (GD).

    Methods: A prospective analysis was conducted of patients with SH due to GD between 2007 and 2013 with at least 12 months of follow-up. SH was diagnosed if serum thyrotropin (TSH) was below the laboratory reference range (0. Read More

    Polymorphic variants of the HSD11B1 gene may be involved in adverse metabolic effects of glucocorticoid replacement therapy in Addison's disease.
    Eur J Intern Med 2016 Jun 13;31:99-104. Epub 2016 Apr 13.
    Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego, 60-355 Poznan, Poland.

    Diagnosis and Management of Hereditary Thyroid Cancer.
    Recent Results Cancer Res 2016 ;205:29-44
    St. George's, University of London, London, UK.
    Thyroid cancers are largely divided into medullary (MTC) and non-medullary (NMTC) cancers , depending on the cell type of origin. Familial non-medullary thyroid cancer (FNMTC) comprises about 5-15% of NMTC and is a heterogeneous group of diseases, including both non-syndromic and syndromic forms. Non-syndromic FNMTC tends to manifest papillary thyroid carcinoma , usually multifocal and bilateral . Read More

    Effect of steroid replacement on thyroid function and thyroid autoimmunity in Addison's disease with primary hypothyroidism.
    Indian J Endocrinol Metab 2016 Mar-Apr;20(2):162-6
    Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
    Background: Steroid replacement without thyroxine supplementation normalizes thyroid function test (TFT) in some but not all Addison's disease patients with primary hypothyroidism. Both autoimmune and nonautoimmune mechanisms contribute to this improvement in TFT. However, the documentation of the change in thyroid autoimmunity after cortisol replacement is very limited in the literature. Read More

    [Adrenal insufficiency of the adult].
    Rev Med Interne 2016 Dec 22;37(12):820-826. Epub 2016 Mar 22.
    Service d'endocrinologie-métabolisme, Institut E3M, hôpital Pitié-Salpêtrière, 83, boulevard de l'Hôpital, 75013 Paris, France.
    Adrenal insufficiency is a rare but life-threatening disorder. Clinical manifestations include fatigue, weight loss, gastrointestinal manifestations and skin hyperpigmentation, the latter being specific of primary adrenal failure. Because of non-specific clinical features of this rare disorder, diagnosis can be delayed and adrenal failure be revealed by an acute crisis. Read More

    Anorexia nervosa: a mistaken diagnosis.
    BMJ Case Rep 2016 Mar 22;2016. Epub 2016 Mar 22.
    Department of Paediatrics, Maidstone and Tunbridge Wells NHS Trust, Kent, Aylesford, UK.
    Eating disorders in the form of anorexia and bulimia are becoming increasingly common in young adults and children. Most of the patients are initially seen by their general practitioner (GP) and it may take several months before the facts are pieced together and an underlying eating disorder is identified. However, other medical conditions, albeit rare, should be considered when assessing these young adults as potentially missing them can lead to devastating consequences. Read More

    Diffuse large B-cell lymphoma of the adrenal gland: a rare cause of primary adrenal insufficiency.
    BMJ Case Rep 2016 Mar 18;2016. Epub 2016 Mar 18.
    Department of Endocrinology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
    Although it is a rare entity, primary lymphoma of the adrenal gland should be considered in the differential diagnosis of bilateral nodular adrenal lesions, particularly when there is evidence of associated adrenal insufficiency. We describe the case of an 83-year-old woman admitted to the emergency department due to a month's history of asthenia, weight loss, anorexia and nausea. Abdominopelvic CT showed bilateral nodular lesions of adrenal glands and a stimulation test with tetracosactide was compatible with primary adrenal insufficiency. Read More

    Understanding kidney transplant patients' treatment choices: The interaction of emotion with medical and social influences on risk preferences.
    Soc Sci Med 2016 Apr 18;155:43-50. Epub 2016 Feb 18.
    King's College London, Division of Health and Social Care Research, Faculty of Life Sciences and Medicine, Addison House, Guy's Campus, London SE1 1UL, United Kingdom. Electronic address:
    Following renal transplantation patients experience on-going immunosuppressant medication to reduce the risk of graft rejection. Over the long term the side effects of immunosuppressive drugs may affect graft survival and significantly increase risks of cancers, stroke and cardiovascular disease. To reduce these risks research is underway to develop a biomarker test to identify those patients who are likely to be 'tolerant' to their graft and therefore able to reduce immunosuppression. Read More


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