5,152 results match your criteria Addison Disease


Preformulation and Evaluation of Tofacitinib as a Therapeutic Treatment for Asthma.

AAPS PharmSciTech 2019 Apr 16;20(5):167. Epub 2019 Apr 16.

Department of Pharmaceutical Sciences, University of Arizona, Tucson, Arizona, USA.

Preformulation studies on tofacitinib citrate, a small molecule JAK3 specific inhibitor, have not been previously reported in literature. We therefore conducted several preformulation studies on tofacitinib citrate, and its free base, to better understand factors that affect its solubility, stability, and solid-state characteristics. Further, the results of the preformulation studies helped facilitate the development of a nebulized formulation of tofacitinib citrate for inhalational delivery to house dust mite allergen-challenged, BALB/c mice as a potential treatment for eosinophilic asthma. Read More

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http://link.springer.com/10.1208/s12249-019-1377-0
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http://dx.doi.org/10.1208/s12249-019-1377-0DOI Listing
April 2019
2 Reads

Role of heat shock protein and cytokine expression as markers of clinical outcomes in Glutamine-supplemented parenteral nutrition in surgical ICU patients.

Clin Nutr 2019 Mar 13. Epub 2019 Mar 13.

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA; Center for Clinical and Molecular Nutrition, Emory University School of Medicine, Atlanta, GA 30322, USA; Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA. Electronic address:

Background: Nutrients, such as glutamine (GLN), have been shown to effect levels of a family of protective proteins termed heat shock proteins (HSPs) in experimental and clinical critical illness. HSPs are believed to serve as extracellular inflammatory messengers and intracellular cytoprotective molecules. Extracellular HSP70 (eHSP70) has been termed a chaperokine due to ability to modulate the immune response. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.02.045DOI Listing
March 2019
1 Read
4.476 Impact Factor

New Variant of MELAS Syndrome With Executive Dysfunction, Heteroplasmic Point Mutation in the Gene (m.12015T>C; p.Leu419Pro) and Comorbid Polyglandular Autoimmune Syndrome Type 2.

Front Immunol 2019 21;10:412. Epub 2019 Mar 21.

Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Mitochondrial diseases are caused by dysfunctions in mitochondrial metabolic pathways. MELAS syndrome is one of the most frequent mitochondrial disorders; it is characterized by encephalopathy, myopathy, lactic acidosis, and stroke-like episodes. Typically, it is associated with a point mutation with an adenine-to-guanine transition at position 3243 of the mitochondrial DNA (mtDNA; m. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437310PMC
March 2019
2 Reads

Reproducibility and responsiveness of gait initiation in Parkinson's disease.

J Biomech 2019 Apr 18;87:197-201. Epub 2019 Mar 18.

University of Utah, Department of Physical Therapy and Athletic Training, 520 Wakara Way, Salt Lake City, UT 84108, USA. Electronic address:

Persons with Parkinson's disease (PD) have significant impairments in functional mobility, including the ability to initiate gait. Three-dimensional analysis of kinetic and kinematic outcomes has become one of the most powerful tools in evaluating abnormalities in gait initiation for persons with PD. Surprisingly however, the psychometric properties of spatial and temporal measures of gait initiation for persons with PD have not been established using force-platforms. Read More

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http://dx.doi.org/10.1016/j.jbiomech.2019.03.009DOI Listing
April 2019
1 Read

Stress, Resilience, and Cardiovascular Disease Risk Among Black Women.

Circ Cardiovasc Qual Outcomes 2019 Apr;12(4):e005284

College of Public Health, Center for Biostatistics, College of Medicine, The Ohio State University, Columbus (A.L.).

Background: Empirical data on the link between stress and cardiovascular disease (CVD) risk among black women is limited. We examined associations of stressful life events and social strain with incident CVD among black women and tested for effect modification by resilience.

Methods And Results: Our analysis included 10 785 black women enrolled in the Women's Health Initiative Observational Study and Clinical Trials cohort. Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005284DOI Listing
April 2019
3 Reads

Representation of Patients with Cardiovascular Disease in Pivotal Cancer Clinical Trials.

Circulation 2019 Mar 18. Epub 2019 Mar 18.

Ohio State University, Columbus, OH.

Cardiovascular disease (CVD) is increasingly common among new cancer patients, with a reported prevalence near 30% at diagnosis. Cancer patients with concurrent CVD have poorer outcomes than those without CVD. Despite the high prevalence of CVD and its prognostic significance, there is limited evidence to guide the care of this increasing population. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.039180DOI Listing
March 2019
16 Reads

Broadening the Spectrum of Adulthood X-Linked Adrenoleukodystrophy: A Report of Two Atypical Cases.

Front Neurol 2019 6;10:70. Epub 2019 Feb 6.

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

X-linked adrenoleukodystrophy (x-ALD) is a rare genetic disorder caused by a mutation in the gene, which encodes for a peroxisomal very long chain fatty acid transporter. Clinically, x-ALD can present a wide spectrum of different phenotypes: asymptomatic carriers, Addison only, cerebral x-ALD, and myelopathy with/without evidence of peripheral axonopathy (Adrenomyeloneuropathy). We report on two cases of adult x-ALD, with atypical phenotypes: A 37-years-old male with a 2-years-long history of spastic paraparesis, urinary urgency, and subclinical adrenocortical insufficiency. Read More

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http://dx.doi.org/10.3389/fneur.2019.00070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372518PMC
February 2019
2 Reads

Immune Checkpoint Blockade Anti-PD-L1 as a Trigger for Autoimmune Polyendocrine Syndrome.

J Endocr Soc 2019 Feb 8;3(2):496-503. Epub 2019 Jan 8.

Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Context: The programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) pathway is a key regulator in T-cell activation and tolerance, limiting effector T-cell function in peripheral tissues. Atezolizumab, an anti-PD-L1 monoclonal antibody, is approved for treatment of some types of advanced cancer. Its main treatment-related adverse events are immune related, such as thyroid dysfunction and hypophysitis. Read More

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http://dx.doi.org/10.1210/js.2018-00366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364624PMC
February 2019
7 Reads

SIADH versus adrenal insufficiency: a life-threatening misdiagnosis.

Ital J Pediatr 2019 Feb 6;45(1):23. Epub 2019 Feb 6.

University of Trieste, Piazzale Europa, 1, 34127, Trieste, Italy.

Background: Primary adrenal insufficiency (PAI) in children is an uncommon but severe condition which can be either inherited or acquired. It consists in clinical manifestation of defective production or ineffective action of endogenous glucocorticoids; deficiency in mineralocorticoids and adrenal androgens may coexist. Diagnosis of PAI in children and young people can be challenging; while adrenal crisis (acute decompensation) is a life-threatening condition, with patient presenting with characteristic features of hypoglycemia, hypotension, collapse and coma, chronic adrenal insufficiency may present with vague and non-specific symptoms, making the diagnosis more difficult. Read More

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http://dx.doi.org/10.1186/s13052-019-0614-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366080PMC
February 2019
11 Reads

Extreme Competence: Keystone Hosts of Infections.

Trends Ecol Evol 2019 Apr 29;34(4):303-314. Epub 2019 Jan 29.

Environmental Futures Research Institute, Griffith University, Nathan, QLD 4111, Australia.

Individual hosts differ extensively in their competence for parasites, but traditional research has discounted this variation, partly because modeling such heterogeneity is difficult. This discounting has diminished as tools have improved and recognition has grown that some hosts, the extremely competent, can have exceptional impacts on disease dynamics. Most prominent among these hosts are the superspreaders, but other forms of extreme competence (EC) exist and others await discovery; each with potentially strong but distinct implications for disease emergence and spread. Read More

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http://dx.doi.org/10.1016/j.tree.2018.12.009DOI Listing
April 2019
4 Reads

Managing thymic enlargement in Graves' disease.

Endocrinol Diabetes Metab Case Rep 2019 Jan 31;2019. Epub 2019 Jan 31.

Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff, UK.

Thymic enlargement (TE) in Graves' disease (GD) is often diagnosed incidentally when chest imaging is done for unrelated reasons. This is becoming more common as the frequency of chest imaging increases. There are currently no clear guidelines for managing TE in GD. Read More

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http://dx.doi.org/10.1530/EDM-18-0119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365683PMC
January 2019
5 Reads

Research priorities to inform "Treat All" policy implementation for people living with HIV in sub-Saharan Africa: a consensus statement from the International epidemiology Databases to Evaluate AIDS (IeDEA).

J Int AIDS Soc 2019 Jan;22(1):e25218

Institute for Implementation Science in Population Health, City University of New York, New York, NY, USA.

Introduction: "Treat All" - the treatment of all people with HIV, irrespective of disease stage or CD4 cell count - represents a paradigm shift in HIV care that has the potential to end AIDS as a public health threat. With accelerating implementation of Treat All in sub-Saharan Africa (SSA), there is a need for a focused agenda and research to identify and inform strategies for promoting timely uptake of HIV treatment, retention in care, and sustained viral suppression and addressing bottlenecks impeding implementation.

Methods: The Delphi approach was used to develop consensus around research priorities for Treat All implementation in SSA. Read More

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http://dx.doi.org/10.1002/jia2.25218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338103PMC
January 2019
9 Reads
5.090 Impact Factor

Therapy Side Effects in Systemic Lupus Erythematosus.

Curr Health Sci J 2018 Jul-Sep;44(3):316-321. Epub 2018 Jul 15.

Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania.

Glucosteroids (GS) are widely used drugs for various inflammatory pathologies (Nephrotic syndrome, Proliferative glomerulonephritis, Extramembrane glomerulonephritis, Nephropathy of the Nodous Poliarterita (PAN), Nephropathy from purple Henoch-Schonlein, lupus nephropathy (LN), Acute adrenal insufficiency Waterhouse-Friederichsen, Chronic adrenal insufficiency Addison, Systemic Lupus Erythematosus (SLE), Polymyositis and dermatomyositis, Chronic granulomatosis, Crohn's disease, Hemorrhagic rectocolitis, Hemolytic anemias, Acute leukemias and chronic lymphocytic leukemia, Hodgkin's lymphoma). Although they are prescribed for their anti-inflammatory and immunosuppressive properties, they also have many side effects, hyperglycemia being one of the most common and representative, which is why these drugs need careful monitoring when administered over the long term. This paper presents the case of a 39 year old patient diagnosed with systemic lupus erythematosus (SLE) with class IV lupus nephropathy (LN) who developed numerous complications due to the pathogenic side effects: diabetes, amenorrhea, recurrent infections, and depression. Read More

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http://dx.doi.org/10.12865/CHSJ.44.03.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311221PMC
July 2018
13 Reads

[Cardiovascular and metabolic impact of glucocorticoid substitution therapy in patients with Addison's disease].

Pan Afr Med J 2018 6;30:251. Epub 2018 Aug 6.

Service d'Endocrinologie et Diabétologie du CHU Hédi Chaker Sfax, Tunisie.

Recent studies conducted in patients with Addison's disease (AD) highlighted that this disease, even after treatment, is a significant cause of morbi-mortality. This study aims to determine the cardiovascular and metabolic deleterious impact of long-course glucocorticoid substitution therapy. We conducted a retrospective study of 28 patients with treated Addison's disease evolving for more than 15 years. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.251.12546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307925PMC
January 2019
12 Reads

Predicted Benign and Synonymous Variants in Cause Primary Adrenal Insufficiency Through Missplicing.

J Endocr Soc 2019 Jan 30;3(1):201-221. Epub 2018 Oct 30.

Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.

Primary adrenal insufficiency (PAI) is a potentially life-threatening condition that can present with nonspecific features and can be difficult to diagnose. We undertook next generation sequencing in a cohort of children and young adults with PAI of unknown etiology from around the world and identified a heterozygous missense variant (rs6161, c.940G>A, p. Read More

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http://dx.doi.org/10.1210/js.2018-00130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316989PMC
January 2019
5 Reads

Identification and Functional Analysis of Six Mutations in Patients With X-Linked Adrenal Hypoplasia Congenita.

J Endocr Soc 2019 Jan 12;3(1):171-180. Epub 2018 Dec 12.

Center of Excellence for Medical Genetics, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Context: () mutations cause X-linked adrenal hypoplasia congenita (AHC) and hypogonadotropic hypogonadism (HH) in affected male patients. Affected individuals typically present with early-onset adrenal insufficiency and develop HH during puberty. Rare cases can present with late-onset adrenal insufficiency or other unusual phenotypes. Read More

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http://dx.doi.org/10.1210/js.2018-00270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316980PMC
January 2019
3 Reads

Sex-Specific Risk of Cardiovascular Disease in Autoimmune Addison Disease-A Population-Based Cohort Study.

J Clin Endocrinol Metab 2019 Jun;104(6):2031-2040

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Context: Little is known of cardiovascular disease (CVD) in autoimmune Addison disease (AAD). Inadequate glucocorticoid replacement might potentially increase CVD risk.

Objective: To examine CVD in AAD in subgroups of ischemic heart disease (IHD) and cerebrovascular disease (CeVD) and investigate the effects of glucocorticoid and mineralocorticoid dosing. Read More

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http://dx.doi.org/10.1210/jc.2018-02298DOI Listing
June 2019
5 Reads

Persuasive bodies: Testimonies of deep brain stimulation and Parkinson's on YouTube.

Soc Sci Med 2019 Feb 24;222:44-51. Epub 2018 Dec 24.

Department of Global Health and Social Medicine, Kings College London, UK. Electronic address:

Contemporary publics actively engage with diverse forms of media when seeking health-related information. The hugely popular digital media platform YouTube has become one means by which people share their experiences of healthcare. In this paper, we examine amateur YouTube videos featuring people receiving Deep Brain Stimulation (DBS) for the treatment of Parkinson's disease. Read More

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http://dx.doi.org/10.1016/j.socscimed.2018.12.036DOI Listing
February 2019
2 Reads

The plasma peptides of ovarian cancer.

Clin Proteomics 2018 21;15:41. Epub 2018 Dec 21.

1Ryerson Analytical Biochemistry Laboratory (RABL), Department of Chemistry and Biology, Ryerson University, Toronto, Canada.

Background: It may be possible to discover new diagnostic or therapeutic peptides or proteins from blood plasma by using liquid chromatography and tandem mass spectrometry to identify, quantify and compare the peptides cleaved ex vivo from different clinical populations. The endogenous tryptic peptides of ovarian cancer plasma were compared to breast cancer and female cancer normal controls, other diseases with their matched or normal controls, plus ice cold plasma to control for pre-analytical variation.

Methods: The endogenous tryptic peptides or tryptic phospho peptides (i. Read More

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http://dx.doi.org/10.1186/s12014-018-9215-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302491PMC
December 2018
8 Reads

HLA-DQB1 Position 57 Defines Susceptibility to Isolated and Polyglandular Autoimmunity in Adults: Interaction With Gender.

J Clin Endocrinol Metab 2019 Jun;104(6):1907-1916

Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, University Hospital Frankfurt, Frankfurt, Germany.

Context: Autoimmune endocrinopathies result from environmental triggers on the genetic background of risk alleles, especially HLA-DR and HLA-DQ with alanine (Ala) in HLA-DQB1 position 57 (Ala57), whereas amino acid Asp57 is protective.

Objectives: Differentiate the effects of HLA-DQB1 amino acid variants at position 57 in adult patients with isolated endocrinopathies and autoimmune polyglandular syndrome type 2 (APS-2) compared with healthy controls in relation to gender.

Setting: University Hospital Frankfurt, Frankfurt, Germany. Read More

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http://dx.doi.org/10.1210/jc.2018-01621DOI Listing
June 2019
4 Reads

Body-weight goals, trends, and weight-loss techniques among patients with peripheral arterial disease.

Nutr Health 2019 Mar 23;25(1):47-52. Epub 2018 Dec 23.

4 Center for Visual and Neurocognitive Rehabilitation and Geriatric Research and Education Center, Atlanta VA Medical Center, Atlanta, Georgia, USA.

Background:: Obesity contributes to negative outcomes in peripheral arterial disease (PAD). Little is known about the body-weight goals and trends among patients with PAD.

Aim:: The aim of this study was to explore self-reported body-weight trends and methods used to achieve weight loss in patients with PAD. Read More

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http://dx.doi.org/10.1177/0260106018817190DOI Listing
March 2019
2 Reads

Exploratory study of the impact of perceived reward on habit formation.

BMC Psychol 2018 Dec 20;6(1):62. Epub 2018 Dec 20.

Department of Disease Control, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

Background: Habits (learned automatic responses to contextual cues) are considered important in sustaining health behaviour change. While habit formation is promoted by repeating behaviour in a stable context, little is known about what other variables may contribute, and whether there are variables which may accelerate the habit formation process. The aim of this study was to explore variables relating to the perceived reward value of behaviour - pleasure, perceived utility, perceived benefits, and intrinsic motivation. Read More

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http://dx.doi.org/10.1186/s40359-018-0270-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302524PMC
December 2018
5 Reads

Thyroid and celiac disease in pediatric age: a literature review.

Acta Biomed 2018 Dec 17;89(9-S):11-16. Epub 2018 Dec 17.

Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Chronic autoimmune thyroid disease or Hashimoto thyroiditis (HT) and Graves-Basedow disease (GD) are the main autoimmune thyroid diseases in pediatric age. Both are characterized by the production of anti-thyroid antibodies, by an infiltration of autoreactive B and T lymphocytes into the thyroid parenchyma and by alterations in thyroid function (hyperthyroidism in GD, normal function or subclinical hypothyroidism in HT with possible evolution towards manifest hypothyroidism). Celiac disease (CD) is a systemic autoimmune disease caused by gluten ingestion in genetically predisposed subjects, its prevalence is around 1% in Western Countries. Read More

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http://dx.doi.org/10.23750/abm.v89i9-S.7872DOI Listing
December 2018
15 Reads

Club Cell Secretory Protein Deficiency Leads to Altered Lung Function.

Am J Respir Crit Care Med 2019 Feb;199(3):302-312

1 Asthma and Airway Disease Research Center.

Rationale: CC16 (club cell secretory protein-16), a member of the secretoglobin family, is one of the most abundant proteins in normal airway secretions and has been described as a serum biomarker for obstructive lung diseases.

Objectives: To determine whether low CC16 is a marker for airway pathology or is implicated in the pathophysiology of progressive airway damage in these conditions.

Methods: Using human data from the birth cohort of the Tucson Children's Respiratory Study, we examined the relation of circulating CC16 levels with pulmonary function and responses to bronchial methacholine challenge from childhood up to age 32 years. Read More

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https://www.atsjournals.org/doi/10.1164/rccm.201807-1345OC
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http://dx.doi.org/10.1164/rccm.201807-1345OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363971PMC
February 2019
12 Reads

Against the Odds.

Authors:
Emily M Bucholz

JAMA 2018 Dec;320(22):2313-2314

Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jama.2018.17821DOI Listing
December 2018
6 Reads

The plasma peptidome.

Clin Proteomics 2018 1;15:39. Epub 2018 Dec 1.

1Ryerson Analytical Biochemistry Laboratory (RABL), Department of Chemistry and Biology, Faculty of Science, Ryerson University, 350 Victoria St, Toronto, ON Canada.

Background: It may be possible to discover new diagnostic or therapeutic peptides or proteins from blood plasma using LC-ESI-MS/MS to identify, with a linear quadrupole ion trap to identify, quantify and compare the statistical distributions of peptides cleaved ex vivo from plasma samples from different clinical populations.

Methods: A systematic method for the organic fractionation of plasma peptides was applied to identify and quantify the endogenous tryptic peptides from human plasma from multiple institutions by C18 HPLC followed nano electrospray ionization and tandem mass spectrometry (LC-ESI-MS/MS) with a linear quadrupole ion trap. The endogenous tryptic peptides, or tryptic phospho peptides (i. Read More

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http://dx.doi.org/10.1186/s12014-018-9211-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271647PMC
December 2018
8 Reads

Case 4: 18-year-old Young Man with Chest Pressure, Shortness of Breath, Fatigue, and Hyponatremia.

Pediatr Rev 2018 Dec;39(12):620-622

Nashaway Pediatrics UMass Memorial Medical Group, Sterling, MA.

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http://dx.doi.org/10.1542/pir.2017-0042DOI Listing
December 2018
3 Reads

Age May Influence the Impact of TRAbs on Thyroid Function and Relapse-Risk in Patients With Graves Disease.

J Clin Endocrinol Metab 2019 May;104(5):1378-1385

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

Context: Thyrotropin receptor antibodies (TRAbs) play a crucial role in the pathogenesis of Graves disease (GD). However, factors that influence the association of TRAbs with thyroid hormones and relapse risk in GD remain unclear.

Objective: We investigated the associations of TRAbs at diagnosis with thyroid hormones and relapse risk and potential factors that can influence these associations in GD. Read More

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http://dx.doi.org/10.1210/jc.2018-01738DOI Listing
May 2019
8 Reads

Addison's disease in antiphospholipid syndrome: a rare complication.

Endocrinol Diabetes Metab Case Rep 2018 22;2018. Epub 2018 Nov 22.

Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.

Addison's disease (AD) is the most common endocrine manifestation of antiphospholipid syndrome (APS), but it remains a very rare complication of the syndrome. It is caused by adrenal venous thrombosis and consequent hemorrhagic infarction or by spontaneous (without thrombosis) adrenal hemorrhage, usually occurring after surgery or anticoagulant therapy. We present a clinical case of a 36-year-old female patient with a previous diagnosis of APS. Read More

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http://dx.doi.org/10.1530/EDM-18-0118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280132PMC
November 2018
4 Reads

Early Clinical Indicators of Addison Disease in Adults With Type 1 Diabetes: A Nationwide, Observational, Cohort Study.

J Clin Endocrinol Metab 2019 Apr;104(4):1148-1157

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Context: Patients with type 1 diabetes mellitus (T1DM) have an increased risk of Addison disease (AD) development, but prediction of those at risk is not possible.

Objective: To determine whether there are early clinical indicators that may denote the development of AD in adults with T1DM.

Design: Observational, matched-cohort study. Read More

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http://dx.doi.org/10.1210/jc.2018-02064DOI Listing
April 2019
13 Reads

Epistaxis and mortality.

Authors:

J Laryngol Otol 2018 Dec 20;132(12):1061-1066. Epub 2018 Nov 20.

Background: Epistaxis is a common emergency presentation to ENT. The 'Epistaxis 2016: national audit of management' collected prospective data over a 30-day audit window in 113 centres. A 30-day all-cause mortality rate of 3. Read More

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http://dx.doi.org/10.1017/S0022215118002013DOI Listing
December 2018
14 Reads

Polyglandular endocrine emergency: lessons from a patient, which a book cannot teach.

BMJ Case Rep 2018 Nov 8;2018. Epub 2018 Nov 8.

Department of Diabetes and Endocrinology, Royal Glamorgan Hospital, Llantrisant, UK.

A 30-year-old woman with polyglandular autoimmune type 2 syndrome was found collapsed at home with a cardiac arrest, which required direct current cardioversion. On admission, she was hypothermic, hypotensive and bradycardic. Initial biochemical investigations were consistent with a pre-renal acute kidney injury, metabolic acidosis and a possible sepsis. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22650
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http://dx.doi.org/10.1136/bcr-2018-226503DOI Listing
November 2018
26 Reads

Dairy milk proteins attenuate hyperglycemia-induced impairments in vascular endothelial function in adults with prediabetes by limiting increases in glycemia and oxidative stress that reduce nitric oxide bioavailability.

J Nutr Biochem 2019 Jan 25;63:165-176. Epub 2018 Sep 25.

Human Nutrition Program, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

Postprandial hyperglycemia (PPH) transiently impairs vascular endothelial function (VEF) in an oxidative stress-dependent manner by decreasing nitric oxide (NO) bioavailability. Dairy milk and its proteins attenuate PPH, but whether this improves VEF is unknown. We hypothesized that dairy milk, mediated by its whey and/or casein proteins, improves VEF by attenuating PPH-induced oxidative stress that otherwise decreases NO bioavailability. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09552863183055
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http://dx.doi.org/10.1016/j.jnutbio.2018.09.018DOI Listing
January 2019
23 Reads

Persistent Underrepresentation of Kidney Disease in Randomized, Controlled Trials of Cardiovascular Disease in the Contemporary Era.

J Am Soc Nephrol 2018 Dec 2;29(12):2782-2786. Epub 2018 Nov 2.

Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas;

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http://dx.doi.org/10.1681/ASN.2018070674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287860PMC
December 2018
23 Reads

Implementing multiple health behaviour change interventions for cardiovascular risk reduction in primary care: a qualitative study.

BMC Fam Pract 2018 10 30;19(1):171. Epub 2018 Oct 30.

School of Population Health and Environmental Sciences, Faculty of Life Sciences and Medicine, King's College London, Addison House, Guy's Campus, London, SE1 1UL, UK.

Background: The implementation of multiple health behaviour change interventions for cardiovascular risk reduction in primary care is suboptimal. This study aimed to identify barriers and facilitators to implementing multiple health behaviour change interventions for cardiovascular disease (CVD) risk reduction in primary care.

Methods: Qualitative study using semi-structured interviews informed by the Theoretical Domains Framework. Read More

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https://bmcfampract.biomedcentral.com/articles/10.1186/s1287
Publisher Site
http://dx.doi.org/10.1186/s12875-018-0860-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208114PMC
October 2018
9 Reads

21-hydroxylase autoantibodies are more prevalent in Turner syndrome but without an association to the autoimmune polyendocrine syndrome type I.

Clin Exp Immunol 2019 Mar 14;195(3):364-368. Epub 2018 Nov 14.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Denmark.

Turner syndrome (TS) is associated with an increased frequency of autoimmunity. Frequently observed autoimmune diseases in TS are also seen in the autoimmune polyendocrine syndrome type I (APS I), of which Addison disease is a key component. An overlapping antibody profile between TS and APS I could be considered. Read More

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http://doi.wiley.com/10.1111/cei.13231
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http://dx.doi.org/10.1111/cei.13231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378376PMC
March 2019
3 Reads

Management of High and Very High-Risk Subjects with Familial Hypercholesterolemia: Results from an Observational Study in Bulgaria.

Folia Med (Plovdiv) 2018 Sep;60(3):389-396

Department of General Medicine, Amgen Europe GmbH,Cambridge, United Kingdom.

Background: Familial hypercholesterolaemia (FH) is a genetic disorder causing accelerated atherosclerosis and premature cardiovascular disease (CVD). This retrospective observational study examined the clinical characteristics and management of FH subjects in Bulgaria over a 12-month period.

Materials And Methods: Twelve cardiology sites participated in this study from May 2015 to May 2016. Read More

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http://dx.doi.org/10.2478/folmed-2018-0020DOI Listing
September 2018
5 Reads

[Genetics of pheochromocytoma and the relevance in surgery].

Chirurg 2019 Jan;90(1):15-22

Medizinische Universitätsklinik, Universitätsklinikum Freiburg, Freiburg, Deutschland.

Chromaffin tumors, e.g. pheochromocytomas and paragangliomas are caused by germline mutations of several susceptibility genes in 30-40% of the patients. Read More

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http://link.springer.com/10.1007/s00104-018-0741-z
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http://dx.doi.org/10.1007/s00104-018-0741-zDOI Listing
January 2019
18 Reads

Development and Validation of the Coeliac Disease Food Attitudes and Behaviours Scale.

Gastroenterol Res Pract 2018 19;2018:6930269. Epub 2018 Aug 19.

School of Psychology, University of Birmingham, 52 Pritchatts Road, Edgbaston, Birmingham B15 2SB, UK.

Objectives: Previous studies on coeliac disease suggest that attitudes towards the gluten-free diet may contribute to the development of disordered eating. This study describes the development and validation of the Coeliac Disease Food Attitudes and Behaviours scale (CD-FAB) to measure these behaviours in coeliac disease.

Research Methods And Procedures: Focus groups were used to develop 33 potential questionnaire items. Read More

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https://www.hindawi.com/journals/grp/2018/6930269/
Publisher Site
http://dx.doi.org/10.1155/2018/6930269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120326PMC
August 2018
17 Reads

Response bias to a randomised controlled trial of a lifestyle intervention in people at high risk of cardiovascular disease: a cross-sectional analysis.

BMC Public Health 2018 Sep 4;18(1):1092. Epub 2018 Sep 4.

Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College Londonz, 10 Cutcombe Road, London, SE5 9RJ, UK.

Background: Research evaluating lifestyle interventions for prevention of cardiovascular disease (CVD) may not reach those most at risk. We compared the response rate to a randomised controlled trial (RCT) of a lifestyle intervention by CVD risk, ethnicity and level of deprivation.

Methods: Primary care patients with a QRisk2 score ≥ 20% were invited to participate in a RCT of an intensive lifestyle intervention versus usual care. Read More

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http://dx.doi.org/10.1186/s12889-018-5939-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124010PMC
September 2018
10 Reads

Primary adrenal insufficiency due to bilateral infiltrative disease.

Endocrine 2018 12 3;62(3):721-728. Epub 2018 Sep 3.

Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Purpose: Evidence on clinical presentation, evaluation, and management of patients with primary adrenal insufficiency (PAI) due to bilateral adrenal infiltrative disease is scarce. Our objective was to review the clinical presentation, biochemical work-up, imaging findings, and management of patients with PAI due to infiltrative adrenal disease in order to determine the best diagnostic and management approach.

Methods: Retrospective study of patients with PAI due to bilateral infiltrative adrenal disease referred for adrenal biopsy during 2000-2014 at Mayo Clinic, Rochester, Minnesota. Read More

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http://dx.doi.org/10.1007/s12020-018-1737-7DOI Listing
December 2018
11 Reads

Does quality of life differ in patients with Addison's disease on different glucocorticoid therapies?

Endocrine 2018 12 21;62(3):740. Epub 2018 Aug 21.

Imperial College London, London, UK.

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http://dx.doi.org/10.1007/s12020-018-1716-zDOI Listing
December 2018
8 Reads

Reduced Slow-Wave Sleep and Altered Diurnal Cortisol Rhythms in Patients with Addison's Disease.

Eur J Endocrinol 2018 10 16;179(5):319-330. Epub 2018 Oct 16.

Department of Psychology, ACSENT Laboratory.

Objectives: Cortisol plays a key role in initiating and maintaining different sleep stages. Patients with Addison's disease (AD) frequently report disrupted sleep, and their hydrocortisone medication regimes do not restore the natural diurnal rhythm of cortisol. However, few studies have investigated relations between sleep quality, especially as measured by polysomnographic equipment, and night-time cortisol concentrations in patients with AD. Read More

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http://dx.doi.org/10.1530/EJE-18-0439DOI Listing
October 2018
27 Reads

Empathy Training Through Symptom Burden Simulation.

Am J Hosp Palliat Care 2019 Feb 13;36(2):169-171. Epub 2018 Aug 13.

1 Transitions LifeCare, Raleigh, NC, USA.

Background:: Providing quality care to hospice and palliative care patients requires the ability to feel and demonstrate empathic behaviors. To acquire a heightened level of empathy, the learner needs to internalize a process of experiencing first-hand real-life symptom burdens common at end of life. Making this happen during new employee orientation is a challenge but with powerful outcomes. Read More

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http://dx.doi.org/10.1177/1049909118793113DOI Listing
February 2019
30 Reads

Delayed Presentation of Isolated Adrenocorticotropin Insufficiency after Nivolumab Therapy for Advanced Non-small-cell lung carcinoma (NSCLC).

BMJ Case Rep 2018 Aug 8;2018. Epub 2018 Aug 8.

Internal Medicine, Michigan State University, Lansing, Michigan, USA.

We describe a 73-year-old man who developed adrenal insufficiency 7 months after completing nivolumab therapy for advanced non-small cell lung cancer. He presented with non-specific symptoms of malaise and fatigue with an insidious 13.6 kilogram weight loss, prompting an evaluation for disease progression, which was negative. Read More

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http://dx.doi.org/10.1136/bcr-2018-225048DOI Listing
August 2018
23 Reads