9,319 results match your criteria Addictive Disorders & Their Treatment[Journal]


NIDA Genomics Consortium White Paper: Coordinating Efforts Between Human and Animal Addiction Studies.

Genes Brain Behav 2019 Apr 23:e12577. Epub 2019 Apr 23.

Department of Neuroscience, The Scripps Research Institute, La Jolla, CA.

The National Institute on Drug Abuse Genetics and Epigenetics Cross-Cutting Research Team convened a diverse group of researchers, clinicians, and healthcare providers on the campus of the University of California, San Diego, in June 2018. The goal was to develop strategies to integrate genetics and phenotypes across species to achieve a better understanding of substance use disorders through associations between genotypes and addictive behaviors. This conference (1) discussed progress in harmonizing large opioid genetics cohorts, (2) discussed phenotypes that are used for genetics studies in humans, (3) examined phenotypes that are used for genetics studies in animal models, (4) identified synergies and gaps in phenotypic analyses of human and animal models, and (5) identified strategies to integrate genetics and genomics data with phenotypes across species. Read More

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http://dx.doi.org/10.1111/gbb.12577DOI Listing

Medications to treat cocaine use disorders: current options.

Curr Opin Psychiatry 2019 Apr 16. Epub 2019 Apr 16.

Addiction Psychiatry Residency Program, Department of Psychiatry & Behavioral Sciences, University of Washington School of Medicine, Director, Center of Excellence in Substance Abuse Treatment and Education (CESATE), VA Puget Sound Healthcare System, Seattle, Washington, USA.

Purpose Of Review: Cocaine is a highly addictive substance with serious medical and mental health consequences. Despite these concerns, there are no food and drug administration-approved medications for the treatment of cocaine use disorder (CUD). Although many medication-assisted treatments (MATs) have been investigated, no clear guidelines exist for clinicians treating patients with CUDs. Read More

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http://Insights.ovid.com/crossref?an=00001504-900000000-9920
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http://dx.doi.org/10.1097/YCO.0000000000000518DOI Listing
April 2019
5 Reads

[Smoking cessation: A challenge for cardiologists and pulmonologists].

Authors:
D Thomas

Rev Mal Respir 2019 Apr 18. Epub 2019 Apr 18.

Institut de cardiologie, groupe hospitalier Pitié-Salpêtrière, Paris Sorbonne université, 47, boulevard de l'Hôpital, 75013 Paris, France. Electronic address:

In addition to public health measures that need to be strongly supported politically, smoking is also a major medical issue. Tobacco dependence is a chronic disease, and, given its extremely addictive nature, treatment for tobacco dependence must be addressed actively by all health professionals. Because smoking is a major contributor to many of the pathologies their specialties address, cardiologists and pulmonologists must be at the forefront of this care. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07618425193003
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http://dx.doi.org/10.1016/j.rmr.2018.03.008DOI Listing
April 2019
1 Read

[Day hospitalisation in addictology].

Soins Psychiatr 2019 Mar - Apr;40(321):41-44

Unité d'addictologie-consultation mémoire, hôpital des Chanaux, 71018 Mâcon cedex, France.

The day hospital in addictology is a recent hospital service for patients with substance use disorders. It lies somewhere between an inpatient withdrawal unit and outpatient consultations. The day hospital service provides care ranging from withdrawal preparation, abstinence support, the reduction of risks or harm and long-term support for patients. Read More

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http://dx.doi.org/10.1016/j.spsy.2019.01.007DOI Listing

Factors associated with alcohol consumption and prescribed drugs with addiction potential among older women and men - the Nord-Trøndelag health study (HUNT2 and HUNT3), Norway, a population-based longitudinal study.

BMC Geriatr 2019 Apr 18;19(1):113. Epub 2019 Apr 18.

Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.

Background: Little is known about factors associated with alcohol consumption and use of drugs with addiction potential in older adults. The aim of this study was to explore the association between socio-demographic variables, physical and mental health and the later (11 years) use of frequent drinking, prescribed drugs with addiction potential and the possible combination of frequent drinking and being prescribed drugs with addiction potential in older adults (≥ 65 years).

Methods: In this longitudinal study, we used data from two surveys of the Nord-Trøndelag Health Study (HUNT2 1995-1997 and HUNT3 2006-2008), a population based study in Norway. Read More

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https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877
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http://dx.doi.org/10.1186/s12877-019-1114-2DOI Listing
April 2019
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Comorbidity Patterns Among Patients With Opioid Use Disorder and Problem Gambling: ADHD Status Predicts Class Membership.

J Dual Diagn 2019 Apr 18:1-12. Epub 2019 Apr 18.

b Department for Applied Psychology: Work Education and Economy , University of Vienna , Vienna , Austria.

Objective: Psychiatric comorbidities are highly prevalent among individuals affected by substance use disorders and those with non-substance-related addictive disorders such as gambling disorder. More recently, the frequent co-occurrence of substance use disorders and attention-deficit hyperactivity disorder (ADHD) has received particular attention. The aim of our study was to identify patterns of psychiatric comorbidity and to examine associations between patient group and ADHD status with class membership. Read More

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https://www.tandfonline.com/doi/full/10.1080/15504263.2019.1
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http://dx.doi.org/10.1080/15504263.2019.1590672DOI Listing
April 2019
1 Read

A critical literature review on emotional intelligence in addiction.

Trends Psychiatry Psychother 2019 Jan-Mar;41(1):87-93. Epub 2019 Apr 1.

Departamento de Psiquiatria, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.

Introduction: Emotional intelligence (EI) has been defined as the ability to perceive, understand, use and manage emotions. Studying EI could potentially be useful in understanding addictive behaviors as well as for designing and planning interventions.

Objectives: To conduct a critical review on EI impairment in addiction disorders. Read More

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http://dx.doi.org/10.1590/2237-6089-2018-0002DOI Listing
April 2019
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Links between sexuality, impulsivity, compulsivity, and addiction in a large sample of university students.

CNS Spectr 2019 Apr 15:1-7. Epub 2019 Apr 15.

Department of Psychiatry and Behavioral Neuroscience,University of Chicago,Chicago, Illinois,USA.

Objective: Non-heterosexual populations experience poorer mental health outcomes than their heterosexual counterparts. Few studies, however, have examined how mental health varies across the continuum of sexual orientation. Nor has any study examined possible links between sexual orientation and traits of impulsivity and compulsivity, which contribute to functional impairment across a broad spectrum of psychiatric disorders. Read More

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http://dx.doi.org/10.1017/S1092852918001591DOI Listing
April 2019
2 Reads

Children's high engagement makes disordered video game playing unique among addictive disorders.

Aust N Z J Psychiatry 2019 Apr 12:4867419844612. Epub 2019 Apr 12.

Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.1177/0004867419844612DOI Listing

Neural correlates of inhibition and reward are negatively associated.

Neuroimage 2019 Apr 8;196:188-194. Epub 2019 Apr 8.

Department of Psychiatry and Behavioral Neuroscience, MC3077, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL, 60637, USA. Electronic address:

Individuals with impulsive and addictive disorders, including drug addiction, binge eating/obesity, and problem gambling, exhibit both impaired control over behavior and heightened sensitivity to reward. However, it is not known whether such deviation in inhibitory and reward circuitry among clinical populations is a cause or consequence of the disorders. Recent evidence suggests that these constructs may be related at the neural level, and together, increase risk for engaging in maladaptive behaviors. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.04.021DOI Listing
April 2019
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Interactions of immediate and long-term action regulation in the course and complications of bipolar disorder.

Philos Trans R Soc Lond B Biol Sci 2019 Feb;374(1766):20180132

1 Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine , Houston, TX 77030-4101 , USA.

Immediate and long-term mechanisms interact in the regulation of action. We will examine neurobiology and practical clinical consequences of these interactions. Long-term regulation of immediate behavioural control is based on analogous responses to highly rewarding or stressful stimuli: (i) impulsivity is a failure of the balance between activation and inhibition in the immediate regulation of action. Read More

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http://dx.doi.org/10.1098/rstb.2018.0132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335464PMC
February 2019
1 Read

The More You Take It, the Better It Works: Six-Month Results of a Nalmefene Phase-IV Trial.

J Clin Med 2019 Apr 6;8(4). Epub 2019 Apr 6.

Addictive Behaviors Unit, Clinic Hospital, University of Barcelona, Barcelona 08036, Spain.

Background: Alcohol use disorders remain a major health problem. Reduced drinking has been increasingly recognized as a valuable alternative to abstinence. Nalmefene has shown in previous, experimental studies to be a useful tool to aid reduced drinking. Read More

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http://dx.doi.org/10.3390/jcm8040471DOI Listing

Cognitive-behavioral treatment with behavioral activation for smoking cessation: Randomized controlled trial.

PLoS One 2019 8;14(4):e0214252. Epub 2019 Apr 8.

Smoking Cessation and Addictive Disorders Unit, Department of Clinical Psychology and Psychobiology, Faculty of Psychology, University of Santiago de Compostela, Galicia, Spain.

Introduction: Behavioral Activation is a behavioral-based treatment that has been proposed as suitable for smoking cessation, as it simultaneously addresses reinforcement-related variables and also mood management. The aim of this study was to compare the effects of a cognitive-behavioral smoking cessation treatment with components of behavioral activation (SCBSCT-BA) with a standard cognitive-behavioral treatment (SCBSCT), and a wait-list control group (WL).

Method: The sample was comprised of 275 adults smokers (61. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214252PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453447PMC

Measuring facets of reward sensitivity, inhibition, and impulse control in individuals with problematic Internet use.

Psychiatry Res 2019 Mar 19;275:351-358. Epub 2019 Mar 19.

Northwestern University, Department of Psychology, Department of Psychiatry, Department of Medical Social Sciences, Institute for Policy Research, and Institute for Innovations in Developmental Sciences, 2029 Sheridan Road, Evanston, IL 60208, United States. Electronic address:

Introduction: Problematic Internet Use (PIU) is the inability to control the amount of time spent on the Internet. Research indicates that abnormalities in reward sensitivity, sensitivity to punishment, and impulse control drive addictive behaviors such as substance abuse and gambling disorders, but it is unclear whether this is also the case in PIU.

Methods: Behavioral tasks and scales were completed by 62 participants (32 PIU individuals and 30 no-PIU individuals) to assess reward sensitivity, sensitivity to punishment, as well as inhibitory function and impulse control. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.03.032DOI Listing
March 2019
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Impaired frontostriatal functional connectivity among chronic opioid using pain patients is associated with dysregulated affect.

Addict Biol 2019 Apr 4. Epub 2019 Apr 4.

Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.

Preclinical studies have shown effects of chronic exposure to addictive drugs on glutamatergic-mediated neuroplasticity in frontostriatal circuitry. These initial findings have been paralleled by human functional magnetic resonance imaging (fMRI) research demonstrating weaker frontostriatal resting-state functional connectivity (rsFC) among individuals with psychostimulant use disorders. However, there is a dearth of human imaging literature describing associations between long-term prescription opioid use, frontostriatal rsFC, and brain morphology among chronic pain patients. Read More

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http://dx.doi.org/10.1111/adb.12743DOI Listing
April 2019
2 Reads

A critical literature review on emotional intelligence in addiction.

Trends Psychiatry Psychother 2019 Apr 1. Epub 2019 Apr 1.

Departamento de Psiquiatria, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.

Introduction: Emotional intelligence (EI) has been defined as the ability to perceive, understand, use and manage emotions. Studying EI could potentially be useful in understanding addictive behaviors as well as for designing and planning interventions.

Objectives: To conduct a critical review on EI impairment in addiction disorders. Read More

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http://dx.doi.org/10.1590/2237-6089-2018-0002DOI Listing
April 2019
1 Read

[Motivational interviewing : A possibility for doctor-patient communication in schizophrenia?]

Nervenarzt 2019 Apr 2. Epub 2019 Apr 2.

Psychiatrie, Psychotherapie und Psychosomatik, Vivantes Klinikum am Urban, Berlin, Deutschland.

Motivational interviewing (MI) has become established nowadays as an approach for a cooperative style of conversation to promote intrinsic motivation for change by exploring and resolving ambivalences. The change of addictive behavior is no longer sought by exerting pressure or lecturing/converting attempts of convincing or persuasion but by activating existing but "buried" or newly acquired self-motivation to change. The MI is now also used to change the treatment of other health-related behavior and chronic diseases, including schizophrenic disorders. Read More

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http://dx.doi.org/10.1007/s00115-019-0702-xDOI Listing
April 2019
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Indeed, not really a brain disorder: Implications for reductionist accounts of addiction.

Behav Brain Sci 2019 01;42:e9

Department of Psychology,University of Amsterdam,PB 15916,1001 NK Amsterdam,The

Borsboom et al.'s formulation provides an opportunity for a fundamental rethink about the "brain disease model" of addiction that dominates research, treatment, policy, and lay understanding of addiction. We also demonstrate how the American opioid crisis provides a contemporary example of how "brain disease" is not moderated by the environmental context but is instead crucially dependent upon it. Read More

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http://dx.doi.org/10.1017/S0140525X18001024DOI Listing
January 2019
3 Reads

Association of variants of prodynorphin promoter 68-bp repeats in caucasians with opioid dependence diagnosis: Effect on age trajectory of heroin use.

Neurosci Lett 2019 Mar 29;704:100-105. Epub 2019 Mar 29.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Ave, New York, NY, 10065, USA.

The dynorphin/kappa opioid receptor (Dyn/KOR) system is involved in reward processing and dysphoria/anhedonia. Exposure to mu-opioid receptor agonists such as heroin increases expression of the prodynorphin gene (PDYN) in the brain. In this study in a Caucasian cohort, we examined the association of the functional PDYN 68-bp repeat polymorphism with opioid use disorders. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.03.038DOI Listing
March 2019
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A Systematic Meta-Review of Impulsivity and Compulsivity in Addictive Behaviors.

Neuropsychol Rev 2019 Mar 30. Epub 2019 Mar 30.

Erasmus University, Rotterdam, The Netherlands.

It is well established that poor inhibitory control confers both a vulnerability to, and maintenance of, addictive behaviors across the substance and behavioral spectrums. By comparison, the role of compulsivity in addictive behaviors has received less research focus. The neurocognitive literature to date is vast, and it is unclear whether there are any convincing lines of systematic evidence delineating whether and how aspects of impulsivity and compulsivity are shared and unique across different substance and behavioral addictive disorders. Read More

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http://link.springer.com/10.1007/s11065-019-09402-x
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http://dx.doi.org/10.1007/s11065-019-09402-xDOI Listing
March 2019
3 Reads

BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates.

Br J Anaesth 2019 Feb 28. Epub 2019 Feb 28.

Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, USA; W.G. Hefner Veterans Affairs Medical Center, Salisbury, NC, USA. Electronic address:

Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have agonist action at both mu opioid peptide (MOP) and nociceptin/orphanin FQ peptide (NOP) receptors. BU10038 is a recently identified bifunctional MOP/NOP partial agonist. Read More

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http://dx.doi.org/10.1016/j.bja.2018.10.065DOI Listing
February 2019
1 Read

A study on the correlates of habit-, reward-, and fear-related motivations in alcohol use disorder.

CNS Spectr 2019 Mar 27:1-8. Epub 2019 Mar 27.

Obsessive, Compulsive, and Anxiety Spectrum Research Program,Institute of Psychiatry, Federal University of Rio de Janeiro,Rio de Janeiro,Brazil.

Objective: We assessed self-reported drives for alcohol use and their impact on clinical features of alcohol use disorder (AUD) patients. Our prediction was that, in contrast to "affectively" (reward or fear) driven drinking, "habitual" drinking would be associated with worse clinical features in relation to alcohol use and higher occurrence of associated psychiatric symptoms.

Methods: Fifty-eight Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) alcohol abuse patients were assessed with a comprehensive battery of reward- and fear-based behavioral tendencies. Read More

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http://dx.doi.org/10.1017/S1092852918001554DOI Listing
March 2019
2 Reads

Quantitative Systems Pharmacological Analysis of Drugs of Abuse Reveals the Pleiotropy of Their Targets and the Effector Role of mTORC1.

Front Pharmacol 2019 8;10:191. Epub 2019 Mar 8.

Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.

Existing treatments against drug addiction are often ineffective due to the complexity of the networks of protein-drug and protein-protein interactions (PPIs) that mediate the development of drug addiction and related neurobiological disorders. There is an urgent need for understanding the molecular mechanisms that underlie drug addiction toward designing novel preventive or therapeutic strategies. The rapidly accumulating data on addictive drugs and their targets as well as advances in machine learning methods and computing technology now present an opportunity to systematically mine existing data and draw inferences on potential new strategies. Read More

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http://dx.doi.org/10.3389/fphar.2019.00191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418047PMC

Methamphetamine produces cardiac damage and apoptosis by decreasing melusin.

Toxicol Appl Pharmacol 2019 Mar 20. Epub 2019 Mar 20.

Department of Forensic Medicine, Guizhou Medical University, Guiyang 550004, China. Electronic address:

Methamphetamine (METH) is an amphetamine-type drug that is highly addictive and widely abused. Many studies have shown that METH exposure causes severe damage not only to the nervous system but also to the cardiovascular system. Melusin protein is a mechanotransducer that plays an important role in maintaining normal heart function. Read More

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http://dx.doi.org/10.1016/j.taap.2019.03.015DOI Listing
March 2019
2 Reads

Trichotillomania: a psychopathological perspective and the psychiatric comorbidity of hair pulling.

Acta Dermatovenerol Alp Pannonica Adriat 2019 Mar;28(1):33-36

Central Michigan University, Saginaw, MI, United States.

Trichotillomania, or hair-pulling disorder, is classified as an obsessive-compulsive spectrum disorder and is seen predominantly in females. This is a non-systematic review article focusing on the psychopathological features of hair pulling. It is speculated that hair pulling may function to provide short-term relief from stress and other unwanted emotional states, thus serving as a method of emotion regulation. Read More

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A Bibliometric Analysis of Scientific Production on Second-Generation Anti-Psychotic Drugs in Malaysia.

Malays J Med Sci 2018 May 28;25(3):40-55. Epub 2018 Jun 28.

Department of Biomedical Sciences (Pharmacology Area), Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain.

Objective: We carried out a bibliometric study on the scientific papers related to second-generation antipsychotic drugs (SGAs) in Malaysia.

Methods: With the SCOPUS database, we selected those documents made in Malaysia whose title included descriptors related to SGAs. We applied bibliometric indicators of production and dispersion, as Price's law and Bradford's law, respectively. Read More

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http://journal.usm.my/journal/05MJMS25032018_OA31.pdf
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http://dx.doi.org/10.21315/mjms2018.25.3.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422559PMC
May 2018
4 Reads

Brief Assessment of Cigarette Demand (BACD): Initial development and correlational results in adults and adolescents.

Exp Clin Psychopharmacol 2019 Mar 21. Epub 2019 Mar 21.

Department of Behavioral & Social Sciences, Center for Alcohol and Addiction Studies, Brown University School of Public Health.

Developing briefer behavioral economic measures is an important priority to ensure that these measures can be used in a variety of different contexts and to reduce participant burden. We developed and sought to validate a Brief Assessment of Cigarette Demand (BACD). A 17-item Cigarette Purchase Task (CPT) and a 3-item BACD were completed concurrently in 2 community samples of smokers (Study 1, adult smokers [n = 80] with substance use disorders; Study 2, adolescent smokers [n = 81]). Read More

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http://doi.apa.org/getdoi.cfm?doi=10.1037/pha0000267
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http://dx.doi.org/10.1037/pha0000267DOI Listing
March 2019
4 Reads

Cognitive remediation therapy of working memory in addictive disorders: An individualized, tailored, and recovery-oriented approach.

Expert Rev Neurother 2019 Apr 20;19(4):285-287. Epub 2019 Mar 20.

b Addiction Medicine, Department of Psychiatry , Lausanne University Hospital , Lausanne , Switzerland.

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http://dx.doi.org/10.1080/14737175.2019.1591950DOI Listing

Sex Differences in Aversion-Resistant Ethanol Intake in Mice.

Alcohol Alcohol 2019 Mar 19. Epub 2019 Mar 19.

Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.

Aims: Compulsive ethanol intake, characterized by persistent consumption despite negative consequences, is an addictive behavior identified by the DSM-5 as a central criterion in diagnosing alcohol use disorders (AUD). Epidemiological data suggest that females transition from recreational alcohol use to AUD more rapidly than males. Because of this potential sex difference in the etiology of AUD, it is critical to assess addictive behaviors such as compulsive intake in both males and females in preclinical studies. Read More

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http://dx.doi.org/10.1093/alcalc/agz022DOI Listing
March 2019
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Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats.

Nat Commun 2019 03 18;10(1):1238. Epub 2019 Mar 18.

Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, 92037, USA.

The activation of a neuronal ensemble in the central nucleus of the amygdala (CeA) during alcohol withdrawal has been hypothesized to induce high levels of alcohol drinking in dependent rats. In the present study we describe that the CeA neuronal ensemble that is activated by withdrawal from chronic alcohol exposure contains ~80% corticotropin-releasing factor (CRF) neurons and that the optogenetic inactivation of these CeA CRF+ neurons prevents recruitment of the neuronal ensemble, decreases the escalation of alcohol drinking, and decreases the intensity of somatic signs of withdrawal. Optogenetic dissection of the downstream neuronal pathways demonstrates that the reversal of addiction-like behaviors is observed after the inhibition of CeA CRF projections to the bed nucleus of the stria terminalis (BNST) and that inhibition of the CRF pathway is mediated by inhibition of the CRF-CRF system and inhibition of BNST cell firing. Read More

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http://dx.doi.org/10.1038/s41467-019-09183-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423296PMC
March 2019
4 Reads

Subtle white matter alterations in schizophrenia identified with a new measure of fiber density.

Sci Rep 2019 Mar 15;9(1):4636. Epub 2019 Mar 15.

Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.

Altered cerebral connectivity is one of the core pathophysiological mechanism underlying the development and progression of information-processing deficits in schizophrenia. To date, most diffusion tensor imaging (DTI) studies used fractional anisotropy (FA) to investigate disrupted white matter connections. However, a quantitative interpretation of FA changes is often impeded by the inherent limitations of the underlying tensor model. Read More

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http://dx.doi.org/10.1038/s41598-019-40070-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420505PMC

[When to transplant a patient with alcoholic liver disease?]

Rev Prat 2018 Sep;68(7):761-765

Maladies de l'appareil digestif, hôpital Claude- Huriez, CHRU de Lille, Lille, France.

When to transplant a patient with alcoholic liver disease? Alcoholic liver disease is the leading cause of cirrhosis in France, but there is only a minority of patients who have access to liver transplantation. Although still controversial, this disease is a validated indication of liver transplantation with survival similar to that of other indications. The survival benefit of transplantation is limited to patients with severe decompensation. Read More

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September 2018
2 Reads

[General principles of treatment in addictology].

Rev Prat 2018 Jun;68(6):680-682

Laboratoire de physiopathologie des maladies psychiatriques, centre psychiatrie et neurosciences, Inserm U894 (Pr M.-O. Krebs), université Paris-Descartes, Paris, France.

General principles of treatment in addictology. Among all mental disorders, addictive pathologies are serious disorders. Their prognosis is severe. Read More

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June 2018
3 Reads

Multimodal neurocognitive markers of interoceptive tuning in smoked cocaine.

Neuropsychopharmacology 2019 Mar 13. Epub 2019 Mar 13.

Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.

Contemporary neurocognitive models of drug addiction have associated this condition with changes in interoception -namely, the sensing and processing of body signals that fulfill homeostatic functions relevant for the onset and maintenance of addictive behavior. However, most previous evidence is inconsistent, behaviorally unspecific, and virtually null in terms of direct electrophysiological and multimodal markers. To circumvent these limitations, we conducted the first assessment of the relation between cardiac interoception and smoked cocaine dependence (SCD) in a sample of (a) 25 participants who fulfilled criteria for dependence on such a drug, (b) 22 participants addicted to insufflated clorhidrate cocaine (only for behavioral assessment), and (c) 25 healthy controls matched by age, gender, education, and socioeconomic status. Read More

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http://www.nature.com/articles/s41386-019-0370-3
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http://dx.doi.org/10.1038/s41386-019-0370-3DOI Listing
March 2019
4 Reads

Assessment of food addiction using the Yale Food Addiction Scale 2.0 in individuals with binge-eating disorder symptomatology: Factor structure, psychometric properties, and clinical significance.

Psychiatry Res 2019 Mar 9. Epub 2019 Mar 9.

School of Psychology, Deakin University, 1 Gheringhap Street, Geelong, VIC 3220, Australia.

The Yale Food Addiction Scale 2.0 (YFAS) assesses addiction-like eating of palatable foods based on the 11 diagnostic criteria for substance use disorder in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). This study was the first to investigate the factor structure, psychometric properties, and clinical significance of the YFAS 2. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.03.003DOI Listing
March 2019
1 Read

[Internet-related disorders-old and new challenges. Conference report on the 10th symposium of the German Association on Internet-Related Disorders].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2019 Apr;62(4):486-492

Grüsser Sinopoli-Ambulanz für Spielsucht, Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Untere Zahlbacher Str. 8, 55131, Mainz, Deutschland.

Internet-related disorders have become a growing challenge for psychosocial healthcare and society. For ten years, the German Association on Internet-Related Disorders has been a cooperative network, bringing together caregiving professionals and researchers, fostering our knowledge and expertise in facing this health issue. The conference "Categorically after 10 years," held in November 2018, was the annual meeting of these experts. Read More

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http://dx.doi.org/10.1007/s00103-019-02919-9DOI Listing

Psychosocial Issues in Long-Term Survivors of Testicular Cancer.

Front Endocrinol (Lausanne) 2019 25;10:113. Epub 2019 Feb 25.

Medical Oncology Department, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRCCS, Meldola, Italy.

Testicular cancer is the most frequent tumor in young males aged 15-39 years. As cure rates are currently around 90%, the prevalence of survivors is increasing. However, a disease-free condition does not necessarily correspond to a life free of physical and psychosocial health problems. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2019.00113
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http://dx.doi.org/10.3389/fendo.2019.00113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397854PMC
February 2019
4 Reads

Endocannabinoid-mediated synaptic plasticity and substance use disorders.

Neurologia 2019 Mar 8. Epub 2019 Mar 8.

Centro Médico Diagnóstico, Pamplona, España.

Drugs impact brain reward circuits, causing dependence and addiction, in a condition currently described as substance use disorders. Mechanisms of synaptic plasticity in these circuits are crucial in the development of addictive behaviour, and endocannabinoids, particularly anandamide and 2-arachidonyl-glycerol, participate in normal neuroplasticity. Substance use disorders are known to be associated with disruption of endocannabinoid-mediated synaptic plasticity, among other phenomena. Read More

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http://dx.doi.org/10.1016/j.nrl.2018.12.004DOI Listing
March 2019
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Desire thinking as a predictor of drinking status following treatment for alcohol use disorder: A prospective study.

Addict Behav 2019 Mar 5;95:70-76. Epub 2019 Mar 5.

Centre for Addictive Behaviours Research, School of Applied Sciences, London South Bank University, London, UK. Electronic address:

Research has indicated that craving is one of the strongest predictors of treatment outcome and relapse in Alcohol Use Disorders (AUD) but there is little consensus on the factors that may influence its activation and escalation. Research has also shown that desire thinking is an important cognitive process which may exacerbate craving in problem drinkers. The aim of present study was to explore, for the first time, the role of desire thinking in prospectively predicting relapse, craving and binge drinking in patients receiving treatment for AUD. Read More

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http://dx.doi.org/10.1016/j.addbeh.2019.03.004DOI Listing

Exploratory study examining associations between prescription opioid dose and delay discounting in patients with chronic pain.

J Opioid Manag 2019 Jan/Feb;15(1):19-25

Department of Psychiatry, Oregon Health & Science University, Portland, Oregon; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon; Oregon Institute for Occupational Health Sciences, Portland, Oregon.

Objective: Although some research has identified correlates of high-dose opioid prescriptions, relatively little is known about factors that lead to higher doses. Delay discounting (DD), defined as the subjective value of a reward declining as a function of the delay to that reward, is an objective measure of impulsivity. DD is commonly studied in the context of addictive behaviors, and findings consistently demonstrate greater DD among individuals with opioid use disorders. Read More

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http://dx.doi.org/10.5055/jom.2019.0482DOI Listing
March 2019
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Mummy, daddy, and addiction: Implicit insecure attachment is associated with substance use in college students.

Exp Clin Psychopharmacol 2019 Mar 11. Epub 2019 Mar 11.

Clinical Research Unit, Poitiers Hospital.

Indirect measures of cognition have become an important tool in research on addiction. To date, however, no research has examined whether indirect measures of parent attachment relate to substance use. To examine this issue, a sample of college students (N = 121) was asked to complete two measures of explicit attachment (the Relationship Questionnaire; Bartholomew & Horowitz, 1991, and the Adult Attachment Styles; Collins & Read, 1990), and a measure of implicit attachment (the Single Category Implicit Association Test, Karpinski & Steinman, 2006). Read More

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http://dx.doi.org/10.1037/pha0000266DOI Listing
March 2019
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Bad Choices Make Good Stories: The Impaired Decision-Making Process and Skin Conductance Response in Subjects With Smartphone Addiction.

Front Psychiatry 2019 22;10:73. Epub 2019 Feb 22.

Department of Mental Health, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Smartphone Addiction (SA) has caused negative consequences and functional impairments in college students, such as reduction of academic performance and impairment in sleep quality. Studies have shown that individuals with chemical and behavioral dependencies have a bias in decision-making process, which leads to short-term advantageous choices even if they cause long-term harm. This bias in decision-making process is accompanied by a change in somatic markers and is associated with the development and maintenance of addictive behavior. Read More

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https://www.frontiersin.org/article/10.3389/fpsyt.2019.00073
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http://dx.doi.org/10.3389/fpsyt.2019.00073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395375PMC
February 2019
8 Reads

Efficacy of Pharmacological Interventions in Targeting Decision-Making Impairments across Substance and Behavioral Addictions.

Neuropsychol Rev 2019 Mar 9. Epub 2019 Mar 9.

Department of Psychiatry & Behavioral Neuroscience, Pritzker School of Medicine, University of Chicago, ISA, 5841 S. Maryland Avenue, MC 3077, Chicago, IL, 60637, USA.

Decision-making impairments reflect tendencies towards risky or unwise choices as manifested by presence of psychiatric symptoms or cognitive impairment (e.g. representation of value, inhibitory control-response selection, learning). Read More

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http://dx.doi.org/10.1007/s11065-019-09400-zDOI Listing
March 2019
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Reduction in non-abstinent WHO drinking risk levels and depression/anxiety disorders: 3-year follow-up results in the US general population.

Drug Alcohol Depend 2019 Apr 14;197:228-235. Epub 2019 Feb 14.

Columbia University Mailman School of Public Health, 722 West 168th Street, New York, NY 10032, USA; New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA. Electronic address:

Background: Non-abstinent drinking reductions that predict improvement in how individuals feel or function, such as the World Health Organization (WHO) drinking risk levels, may be useful outcomes in clinical trials for alcohol use disorders (AUD).

Methods: Current drinkers in a U.S. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2019.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440807PMC
April 2019
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Water Pipe (Hookah) Smoking and Cardiovascular Disease Risk: A Scientific Statement From the American Heart Association.

Circulation 2019 Mar 8:CIR0000000000000671. Epub 2019 Mar 8.

Tobacco smoking with a water pipe or hookah is increasing globally. There are millions of water pipe tobacco smokers worldwide, and in the United States, water pipe use is more common among youth and young adults than among adults. The spread of water pipe tobacco smoking has been abetted by the marketing of flavored tobacco, a social media environment that promotes water pipe smoking, and misperceptions about the addictive potential and potential adverse health effects of this form of tobacco use. Read More

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http://dx.doi.org/10.1161/CIR.0000000000000671DOI Listing

Incorporating Participatory Action Research in Attention Bias Modification Interventions for Addictive Disorders: Perspectives.

Int J Environ Res Public Health 2019 Mar 6;16(5). Epub 2019 Mar 6.

National Addiction Management Service, Institute of Mental Health, Singapore 539747, Singapore.

Participatory action research was introduced in the 1960s and early 1970s, but it has only been more widely adopted in the recent years. Such methodologies have since been applied to several web & mobile-based interventions in psychiatry. To date no prior review has scoped the extent of the application of such methodologies for web & mobile-based interventions in psychiatry. Read More

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https://www.mdpi.com/1660-4601/16/5/822
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http://dx.doi.org/10.3390/ijerph16050822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427500PMC
March 2019
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An experimental examination of cognitive processes and response inhibition in patients seeking treatment for buying-shopping disorder.

PLoS One 2019 6;14(3):e0212415. Epub 2019 Mar 6.

Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany.

There is an ongoing debate about whether buying-shopping disorder (BSD) should be acknowledged as a behavioral addiction. The current study investigated if mechanisms that play a prominent role in disorders due to substance use or addictive behaviors are relevant in BSD, particularly cue reactivity, craving, cognitive bias and reduced inhibitory control regarding addiction-relevant cues. The study included 39 treatment-seeking patients with BSD and 39 healthy control (HC) participants (29 women and 10 men in each group). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212415PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402626PMC
March 2019
3 Reads

[Neurobiology of opioid dependence].

Anaesthesist 2019 Mar;68(3):179-190

Klinik für Abhängiges Verhalten und Suchtmedizin, LVR-Klinikum Essen, Kliniken der Universität Duisburg-Essen, Virchowstr. 174, 45147, Essen, Deutschland.

Opioid dependence is a chronic mental disease with multifactorial etiology. The neurobiological theory of addiction focuses on the manipulation of the dopaminergic reward system as a basic property of substances with addictive potential including opioids. With regular opioid intake, the manipulation of the reward system results in a cognitive bias towards drug-related stimuli. Read More

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http://dx.doi.org/10.1007/s00101-019-0557-3DOI Listing
March 2019
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[Study on the mechanism of brain damage based on structural covariant network to evaluate the brain structure of nicotine addicts].

Zhonghua Yi Xue Za Zhi 2019 Mar;99(9):669-674

Department of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To explore the neuromechanism of nicotine dependence, structural covariation networks (SCNs) based on voxel-based morphometry (VBM) were used to study the synergistic changes in gray matter volume in different cerebral cortices of nicotine dependent individuals. During the period from August 2016 to February 2018, a total of 118 long-term smokers and 57 non-smoking healthy controls (both 18-55 male volunteers) through online platforms and leaflets were recruited. The subjects were scanned with SIEMENS Skyro 3. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.09.007DOI Listing
March 2019
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An Old Treatment for an Even Older Problem: Does Psychoanalysis Have a Role in the Treatment of Addictive Disorders? A Review of the Literature.

Authors:
Timothy J Legg

J Addict Nurs 2019 Jan/Mar;30(1):4-13

Timothy J. Legg, PhD, PsyD, MS, PMHNP-BC, CARN-AP, MAC, California Southern University, Costa Mesa, California.

The fact that addictive disorders have a significant negative impact on the health of the global population is well documented in contemporary health literature. What is less well documented is the uncomfortable realization that the tools in our armament to help individuals who struggle with addictive disorders are limited. Many individuals will spend their lives "cycling" through the addiction treatment continuum only to again be met with relapse. Read More

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http://dx.doi.org/10.1097/JAN.0000000000000260DOI Listing