10,215 results match your criteria Addictive Disorders & Their Treatment[Journal]


Inhibitory neuromodulation of the putamen to the prefrontal cortex in Internet gaming disorder: How addiction impairs executive control.

J Behav Addict 2020 Jun;9(2):312-324

1Center for Cognition and Brain Disorders, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, PR China.

Background And Aims: Individuals with addictive disorders are usually characterized by impaired executive control, persistent craving and excessive reward-seeking. However, it is unclear whether there is a deviation in the connection pattern among the neural systems implicated in these problem behaviors.

Methods: One hundred thirty-six online gaming players were recruited in the current study (68 Internet gaming disorder (IGD) subjects and 68 recreational game users (RGUs) who served as controls matched on age, sex, years of education, and years of gaming). Read More

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http://dx.doi.org/10.1556/2006.2020.00029DOI Listing

New Challenges in Addiction Medicine: COVID-19 Infection in Patients With Alcohol and Substance Use Disorders-The Perfect Storm.

Am J Psychiatry 2020 Jul 14:appiajp202020040417. Epub 2020 Jul 14.

NIDA Intramural Research Program, Baltimore (all authors); National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research (Leggio), and National Institute of Neurological Disorders and Stroke Intramural Research Program (Spagnolo), Bethesda, Md.;Department of Neuroscience, Imaging, and Clinical Science, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy (Montemitro).

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http://dx.doi.org/10.1176/appi.ajp.2020.20040417DOI Listing

Association of Testosterone Levels and Steroid 5-Alpha-Reductase 2 Polymorphisms with Opioid Craving.

Neuropsychobiology 2020 Jul 13:1-10. Epub 2020 Jul 13.

Department of Psychiatry, Social Psychiatry and Psychotherapy, Medical School Hannover, Hannover, Germany.

Background/aims: Opioid dependence is a severe disease which is associated with a high risk of relapse, even in cases of successful withdrawal therapy. Studies have shown alterations of the hypothalamic-pituitary-gonadal axis in opioid-dependent patients, such as decreased testosterone serum levels in affected males. Sex hormones and the steroid 5-alpha-reductase 2 (SRD5A2) V89L polymorphism are associated with craving during alcohol withdrawal, but little is known about their impact on symptomatology of opioid dependence. Read More

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http://dx.doi.org/10.1159/000508681DOI Listing

Roux-en-Y gastric bypass increases GABA-A receptor levels in regions of the rat brain involved in object recognition memory and perceptual acuity.

Physiol Behav 2020 Jul 6:113053. Epub 2020 Jul 6.

Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biosciences, State University of New York at Buffalo, Buffalo, NY; Department of Psychology, State University of New York at Buffalo, Buffalo, NY. Electronic address:

Roux-en-Y gastric bypass surgery (RYGB), one of the most common and successful procedures for combatting obesity, is associated with post-surgery substance use disorder (SUD) and other addictive behaviors in a subset of patients. We investigated the effects of RYGB on GABA-A receptor levels in the rat brain to identify potential mechanisms of this behavior. The GABAergic system is affected in addiction and has been implicated in the pathology of obesity. Read More

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http://dx.doi.org/10.1016/j.physbeh.2020.113053DOI Listing

Alternative flavored and unflavored tobacco product use and cigarette quit attempts among current smokers experiencing homelessness.

Addict Behav Rep 2020 Dec 4;12:100280. Epub 2020 May 4.

University of California, San Francisco, Division of General Internal Medicine, 1001 Potrero Avenue, San Francisco, CA 94110, USA.

Introduction: Alternative tobacco product (ATP) use is common in the general population; however, few studies have explored ATP among individuals experiencing homelessness. We recruited individuals experiencing homelessness who were current cigarette smokers to explore flavored and unflavored ATP use and its association with past-year cigarette quit attempts.

Methods: Using time-location sampling, we recruited participants from eight service sites in San Francisco, CA between December 2017 and July 2018. Read More

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http://dx.doi.org/10.1016/j.abrep.2020.100280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330871PMC
December 2020

International Consensus Statement for the Screening, Diagnosis, and Treatment of Adolescents with Concurrent Attention-Deficit/Hyperactivity Disorder and Substance Use Disorder.

Eur Addict Res 2020 07 7:1-10. Epub 2020 Jul 7.

Parnassia Addiction Research Centre (PARC), Parnassia Psychiatric Institute, The Hague, The Netherlands.

Background: Childhood attention-deficit/hyperactivity disorder (ADHD) is a risk factor for substance misuse and substance use disorder (SUD) in adolescence and (early) adulthood. ADHD and SUD also frequently co-occur in treatment-seeking adolescents, which complicates diagnosis and treatment and is associated with poor treatment outcomes. Research on the effect of treatment of childhood ADHD on the prevention of adolescent SUD is inconclusive, and studies on the diagnosis and treatment of adolescents with ADHD and SUD are scarce. Read More

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http://dx.doi.org/10.1159/000508385DOI Listing

Long-term exposure to ephedrine leads to neurotoxicity and neurobehavioral disorders accompanied by up-regulation of CRF in prefrontal cortex and hippocampus in rhesus macaques.

Behav Brain Res 2020 Jul 4:112796. Epub 2020 Jul 4.

Department of Radiology, The First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Shantou, 515041, Guangdong, China; Shantou University Medical College, No. 22 Xinling Road, Shantou, 515041, Guangdong, China; Guangdong Key Laboratory of Medical Molecular Imaging, No. 57 Changping Road, Shantou, 515041, Guangdong, China. Electronic address:

Drug addiction continues to threaten the health and welfare of people worldwide, and ephedrine abuse is a serious drug problem in many areas of the world. Ephedrine toxicity is thought to induce behavioral effects primarily through actions on the central nervous system. The corticotropin-releasing factor (CRF) system plays an important role in regulating behavioral effects induced by addictive drugs, but whether CRF is related to ephedrine toxicity remains unclear. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112796DOI Listing

Which conditions should be considered as disorders in the International Classification of Diseases (ICD-11) designation of "other specified disorders due to addictive behaviors"?

J Behav Addict 2020 Jun 30. Epub 2020 Jun 30.

21Departments of Psychiatry, Neuroscience and Child Study, Yale University School of Medicine, New Haven, CT, USA.

Background: Gambling and gaming disorders have been included as "disorders due to addictive behaviors" in the International Classification of Diseases (ICD-11). Other problematic behaviors may be considered as "other specified disorders due to addictive behaviors (6C5Y)."

Methods: Narrative review, experts' opinions. Read More

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http://dx.doi.org/10.1556/2006.2020.00035DOI Listing

Alcohol consumption and internalising disorders in young adults of ALSPAC: a population-based study.

J Epidemiol Community Health 2020 Jul 6. Epub 2020 Jul 6.

School of Social and Community Medicine, University of Bristol, Bristol, UK.

Introduction: Depression and harmful alcohol consumption contribute significantly to the global health burden, but in young adults, this relationship is under-researched and conflicted. The aim of this study was to determine the sex-based prevalence and the association between internalising disorders such as depression and alcohol use disorders.

Method: Using the Avon Longitudinal Study of Parents and Children, we assessed the sex-specific prevalence of International Classification of Diseases,Tenth Revision diagnosed generalised anxiety disorder (GAD), depression and fear-based anxieties (FBA) at 24 years (n=3572). Read More

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http://dx.doi.org/10.1136/jech-2020-213922DOI Listing

Childhood Trauma Predicts Less Remission from PTSD among Patients with Co-Occurring Alcohol Use Disorder and PTSD.

J Clin Med 2020 Jun 30;9(7). Epub 2020 Jun 30.

CHRU de Tours, Clinique Psychiatrique Universitaire, 37044 Tours, France.

Post-traumatic stress disorder (PTSD) is highly prevalent among patients hospitalized for an alcohol use disorder (AUD). Hospitalization can improve PTSD and AUD outcomes in some but not all patients, but we lack data on the baseline predictors of PTSD non-remission. This study aimed to determine the baseline risk factors for non-remitted PTSD in patients hospitalized for an AUD. Read More

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http://dx.doi.org/10.3390/jcm9072054DOI Listing

Cigarette Smoking, Coffee Consumption, Alcohol Intake, and Risk of Crohn's Disease and Ulcerative Colitis: A Mendelian Randomization Study.

Inflamm Bowel Dis 2020 Jul 6. Epub 2020 Jul 6.

Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece.

Background: Crohn's disease (CD) and ulcerative colitis (UC) are widely associated with smoking in epidemiological studies, whereas there are conflicting results for the association between CD and UC for both coffee and alcohol consumption. Herein, we aimed to investigate whether cigarette smoking and alcohol and coffee consumption are causally associated with either CD or UC.

Methods: We utilized 540 genome-wide significant single-nucleotide polymorphisms for 3 potentially addictive substances-nicotine, alcohol, and caffeine-to assess the association of smoking, coffee, and alcohol consumption with CD and UC (12,194 CD cases, 12,366 UC cases, and 25,042 controls of European ancestry), using Mendelian randomization analysis. Read More

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http://dx.doi.org/10.1093/ibd/izaa152DOI Listing

[Possibilities of using Mexidol in the complex therapy of mental disorders].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(5):160-164

Kirov military medical Academy, St. Petersburg, Russia.

A review of the current literature on the possible use of mexidol (ethylmethylhydroxypyridine succinate) in the treatment of mental (including addictive) disorders is conducted. The possibility of its use to reduce negative psychopathological symptoms, neurocognitive deficit, manifestations of the antipsychotic syndrome (including its extrapyramidal disorders) in antipsychotic treatment of patients with schizophrenia spectrum disorders and insomnia disorders in the complex therapy of borderline mental disorders has been shown. The potential of mexidol in the treatment of addictive pathology, as well as the effects of intoxication caused by alcohol and other psychoactive (including narcotic) substances, deserves special attention. Read More

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http://dx.doi.org/10.17116/jnevro2020120051160DOI Listing

Reduction in World Health Organization Risk Drinking Levels and Cardiovascular Disease.

Alcohol Clin Exp Res 2020 Jul 3. Epub 2020 Jul 3.

From the Columbia University Mailman School of Public Health, New York, New York.

Background: Reductions in World Health Organization (WHO) risk drinking levels have recently been shown to lower the risk of multiple adverse health outcomes, but prior work has not examined reductions in WHO risk drinking levels in relation to cardiovascular disease (CVD), the leading cause of death for men and women in the United States and of global mortality. This study examined associations between reductions in WHO risk drinking levels and subsequent risk for CVD.

Methods: In a US national survey, 1,058 very-high-risk and high-risk drinkers participated in Wave 1 interviews (2001 to 2002) and Wave 2 follow-ups (2004 to 2005). Read More

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http://dx.doi.org/10.1111/acer.14386DOI Listing

A Latent Class Analysis of Manic and Psychotic Symptoms.

J Nerv Ment Dis 2020 Jun 29. Epub 2020 Jun 29.

Université de Paris, NeuroDiderot, Inserm.

Bipolar spectrum disorders encompass heterogeneous clinical manifestations and comorbidities. A latent class analysis (LCA) was performed in 1846 subjects who experienced an episode of abnormally elevated or irritable mood to identify homogeneous groups of subjects, based on the distribution of 11 manic and 7 psychotic symptoms. LCA identified five classes: 1) two classes with irritability and with low and high level of psychosis (respectively "irritable," 29. Read More

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http://dx.doi.org/10.1097/NMD.0000000000001193DOI Listing

[Mindfulness in Development-oriented Approaches to Substance Use Prevention and Therapy: Rationale, Design and Objectives of the Research Consortium IMAC-Mind].

Prax Kinderpsychol Kinderpsychiatr 2020 Jul;69(4):353-374

Universitätsklinikum Hamburg-Eppendorf Deutsches Zentrum für Suchtfragen des Kindes- und Jugendalters (DZSKJ) Martinistr. 52 20246 Hamburg Deutschland.

Substance use disorders (SUD) are a major contributor to morbidity and mortality. They are typically initiated during adolescence and can have fatal implications for healthy development. Despite substantial scientific advances, there remains a need to prioritize research directed at reducing risks for SUD, particularly in vulnerable periods and populations from a developmental perspective. Read More

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http://dx.doi.org/10.13109/prkk.2020.69.4.353DOI Listing

[Media-associated disorders in childhood and adolescence: Evidence paper of the joint addiction commision of the German societies and professional associations of child and adolescent psychiatry and psychotherapy].

Z Kinder Jugendpsychiatr Psychother 2020 Jul;48(4):303-317

Deutsches Zentrum für Suchtfragen des Kindes- und Jugendalters (DZSKJ), Universitätsklinikum Hamburg-Eppendorf, Hamburg.

Media-associated disorders in childhood and adolescence: Evidence paper of the joint addiction commision of the German societies and professional associations of child and adolescent psychiatry and psychotherapy Media-associated disorders (MAD) describe the problematic use of the internet, certain electronic devices in general as well as digital applications. During childhood and adolescence, digital games and social media are the most commonly used applications. In May 2019, as first MAD "gaming disorder" was included as a clinical diagnosis in the ICD-11. Read More

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http://dx.doi.org/10.1024/1422-4917/a000735DOI Listing

One Is Not Enough: Understanding and Modeling Polysubstance Use.

Front Neurosci 2020 16;14:569. Epub 2020 Jun 16.

Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, United States.

Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative affect, and motivation to maintain drug consumption. SUDs are highly prevalent, with 35 million people meeting criteria for SUD. While drug use and addiction are highly studied, most investigations of SUDs examine drug use in isolation, rather than in the more prevalent context of comorbid substance histories. Read More

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http://dx.doi.org/10.3389/fnins.2020.00569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309369PMC

Co-occurrences of substance use and other potentially addictive behaviors: Epidemiological results from the Psychological and Genetic Factors of the Addictive Behaviors (PGA) Study.

J Behav Addict 2020 Jun 26. Epub 2020 Jun 26.

1Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary.

Background And Aims: Changes in the nomenclature of addictions suggest a significant shift in the conceptualization of addictions, where non-substance related behaviors can also be classified as addictions. A large amount of data provides empirical evidence that there are overlaps of different types of addictive behaviors in etiology, phenomenology, and in the underlying psychological and biological mechanisms. Our aim was to investigate the co-occurrences of a wide range of substance use and behavioral addictions. Read More

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http://dx.doi.org/10.1556/2006.2020.00033DOI Listing

Patients' perception about opioids and addiction in South Korea.

Korean J Pain 2020 Jul;33(3):234-244

Department of Anesthesiology and Pain Medicine, Konkuk University School of Medicine, Seoul, Korea.

Background: Chronic pain affects approximately 22% of the world's population. Opioids can be useful in chronic pain management. However, some patients have negative perception of opioids. Read More

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http://dx.doi.org/10.3344/kjp.2020.33.3.234DOI Listing

Neprilysin controls the synaptic activity of neuropeptides in the intercalated cells of the amygdala.

Mol Pharmacol 2020 Jun 30. Epub 2020 Jun 30.

Charles Perkins Centre D17

Endogenous opioids peptides in the amygdala regulate many of our behaviours and emotional responses. In particular, the endogenous opioid enkephalin plays a significant role in regulating amygdala activity, but its action is strongly limited by peptidases which degrade enkephalin into inactive fragments. Inhibiting peptidases maybe an attractive method to enhance endogenous opioid signalling, however we do not know which specific peptidase/s to target. Read More

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http://dx.doi.org/10.1124/mol.119.119370DOI Listing

Food Addiction among Female Patients Seeking Treatment for an Eating Disorder: Prevalence and Associated Factors.

Nutrients 2020 Jun 26;12(6). Epub 2020 Jun 26.

Addictology and Psychiatry Department, Hôpital Saint Jacques, University Hospital of Nantes, 85 rue Saint Jacques, CEDEX 1, 44 093 Nantes, France.

The concept of "food addiction" (FA) has aroused much focus because of evidence for similarities between overeating and substance use disorders (SUDs). However, few studies have explored this concept among the broad spectrum of eating disorders (ED), especially in anorexia nervosa (AN). This study aimed to assess FA prevalence in ED female patients and to determine its associated factors. Read More

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http://dx.doi.org/10.3390/nu12061897DOI Listing

Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction.

Mol Psychiatry 2020 Jun 29. Epub 2020 Jun 29.

Centre for Addictive Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.

Cocaine addiction is characterized by overwhelming craving for the substance, which drives its escalating use despite adverse consequences. Animal models suggest a disrupted glutamate homeostasis in the nucleus accumbens to underlie addiction-like behavior. After chronic administration of cocaine, rodents show decreased levels of accumbal glutamate, whereas drug-seeking reinstatement is associated with enhanced glutamatergic transmission. Read More

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http://dx.doi.org/10.1038/s41380-020-0828-zDOI Listing

History of child maltreatment and excessive dietary and screen time behaviors in young adults: Results from a nationally representative study.

Prev Med 2020 Jun 24;139:106176. Epub 2020 Jun 24.

Department of Epidemiology, Rollins School of Public Health, Emory University, United States of America.

Child maltreatment is common and has been associated with substance use addictions, yet few studies have examined associations with potentially addictive dietary and screen time behaviors. The goal of this study was to assess associations between retrospectively self-reported child maltreatment (sexual abuse, physical abuse, emotional abuse, and neglect) and excessive self-reported dietary (sugar sweetened beverage and fast food consumption) and screen time behaviors (television/video watching and leisure time computer use) in early adulthood, overall and by sex and race/ethnicity. Associations were examined using data from 10,813 participants 24-32 years old from the National Longitudinal Study of Adolescent to Adult Health. Read More

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http://dx.doi.org/10.1016/j.ypmed.2020.106176DOI Listing

Resting-state connectivity and network parameter analysis in alcohol-dependent males. A simultaneous EEG-MEG study.

J Neurosci Res 2020 Jun 25. Epub 2020 Jun 25.

12 de Octubre Biomedical Research Institute, Madrid, Spain.

There is supporting evidence of alcohol negative effects on the brain: neuroimaging and psychophysiological studies finding anatomical and functional connectivity (FC) changes associated with the dependence process. Thus, the aim of this work was to evaluate brain FC and network characteristics of alcohol-dependent individuals in resting state. For this study, we included males diagnosed with alcohol dependence (N = 25) and a group of healthy individuals (N = 23). Read More

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http://dx.doi.org/10.1002/jnr.24673DOI Listing

Exposure to methamphetamine exacerbates motor activities and alters circular RNA profile of cerebellum.

J Pharmacol Sci 2020 Jun 6. Epub 2020 Jun 6.

Cell Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Methamphetamine (METH) is a psychostimulant drug that acts on monoaminergic systems in the brain. There are several lines of evidence indicating the devastating effects of addictive drugs on the cerebellum. Moreover, it was shown that circular RNAs (circRNAs) have an important role in neurodegenerative disorders. Read More

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http://dx.doi.org/10.1016/j.jphs.2020.05.010DOI Listing

Impulsivity, Emotional Dysregulation and Executive Function Deficits Could Be Associated with Alcohol and Drug Abuse in Eating Disorders.

J Clin Med 2020 Jun 21;9(6). Epub 2020 Jun 21.

Department of Psychiatry, Bellvitge University Hospital-IDIBELL, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.

Background: Empirical data suggests a high comorbid occurrence of eating disorders (EDs) and substance use disorders (SUDs), as well as neurological and psychological shared characteristics. However, no prior study has identified the neuropsychological features of this subgroup. This study examines the prevalence of alcohol and/or drug abuse (A/DA) symptoms in ED patients. Read More

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http://dx.doi.org/10.3390/jcm9061936DOI Listing

Delineating the Psychic Structure of Substance Use and Addictions, from Neurobiology to Clinical Implications: Ten Years Later.

J Clin Med 2020 Jun 18;9(6). Epub 2020 Jun 18.

PISA-School of Experimental and Clinical Psychiatry, 56100 Pisa, Italy.

The diagnosis of substance use disorder is currently based on the presence of specifically identified behavioral symptoms. In addition, other psychiatric signs and symptoms accompany addictive behavior, contributing to the full picture of patients' psychopathologic profile. Historically, such symptoms were confined within the framework of "comorbidity", as comorbid psychiatric disorders or personality traits. Read More

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http://dx.doi.org/10.3390/jcm9061913DOI Listing

[Feasibility on the Internet-based HIV nucleic acid testing with dry blood spots and risk factors associated with HIV infection in men having sex with men in Beijing].

Zhonghua Liu Xing Bing Xue Za Zhi 2020 Jun;41(6):913-918

Beijing Center for Diseases Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing 100013, China.

To understand the prevalence of HIV nucleic acid using internet-based dry blood spots HIV testing strategy in men who had sex with men (MSM) and to probe the factors associated with HIV infection. Using convenient sampling method, 1 375 MSM were recruited and their dry blood spots samples were collected before being mailed to the laboratories for HIV nucleic acid testing. Results were showed to these MSM on a specific website by inputting their codes to it. Read More

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http://dx.doi.org/10.3760/cma.j.cn112338-20190828-00630DOI Listing

Cannabis use the week before admission to psychiatric in-patient service as a marker of severity.

J Psychiatr Res 2020 May 29;129:40-46. Epub 2020 May 29.

Department of Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Research Group on Addictions, Barcelona, Spain; Addictions Research Group, Institut D'Investigacions Biomèdiques August Pi I Sunyer, Barcelona, Spain.

Objective: To evaluate if cannabis dose recorded as standard joint unit (SJU) consumed before admission and other related factors have an influence on psychiatric inpatient's symptom severity and clinical outcomes.

Methods: Cross-sectional study in an acute psychiatric inpatient unit including 106 individuals. Quantity of cannabis was measured as SJU and symptoms severity through the Brief Psychiatric Rating Scale (BPRS). Read More

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http://dx.doi.org/10.1016/j.jpsychires.2020.05.028DOI Listing

Who becomes addicted and to what? psychosocial predictors of substance and behavioral addictive disorders.

Psychiatry Res 2020 Jun 11;291:113221. Epub 2020 Jun 11.

Department of Psychology, Bar-Ilan University, Ramat-Gan 52900, Israel; Leslie and Susan Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel; Department of Psychiatry and Biobehavioral Sciences, 760 Westwood Plaza (C8-746), University of California, Los Angeles (UCLA), California 90095, United States. Electronic address:

A multitude of psychological and social factors likely contribute to the development and maintenance of addictive disorders. As different people develop different addictions, it is important to understand whether psychosocial factors are related differently to different types of addictive disorders. In this study, we examined the unique interaction of personality traits, family environment, and life events in predicting substance (drugs, alcohol) and behavioral (gambling, sex) addictive disorders, among 207 participants suffering from an addictive disorder and 79 controls. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113221DOI Listing

Reward-related attentional capture and cognitive inflexibility interact to determine greater severity of compulsivity-related problems.

J Behav Ther Exp Psychiatry 2020 May 1;69:101580. Epub 2020 May 1.

BrainPark, Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Australia.

Background And Objectives: Neurocognitive processes are key drivers of addictive and compulsive disorders. The current study examined whether reward-related attentional capture and cognitive inflexibility are associated with impulsive and/or compulsive personality traits, and whether these cognitive characteristics interact to predict greater compulsivity-related problems across obsessive-compulsive and drinking behaviors.

Methods: One-hundred and seventy-three participants (mean age = 34. Read More

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http://dx.doi.org/10.1016/j.jbtep.2020.101580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308172PMC

Specific Relapse Predictors: Could Cognitive-Behavioral Treatment for Smoking Cessation Be Improved?

Int J Environ Res Public Health 2020 Jun 17;17(12). Epub 2020 Jun 17.

Department of Clinical Psychology and Psychobiology, Faculty of Psychology, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Relapse remains a frequent and complex phenomenon that is not yet well understood. An under-researched area of study that may provide relevant information concerns the assessment of specific post-treatment variables, rather than the composite measures commonly used to predict smoking relapse. The current study sought to examine the effects of post-treatment smoking-related variables, including withdrawal symptomatology, abstinence self-efficacy, and smoking urgency in negative-affect situations and smoking relapse at the 3 month follow-up. Read More

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http://dx.doi.org/10.3390/ijerph17124317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344644PMC

Activity, cognition, and emotion: Three dimensional pillars of the natural presentations of mood disorders enriched by the "sleep" fourth dimension (ACES).

Bipolar Disord 2020 Jun 17. Epub 2020 Jun 17.

Department of Psychiatry and Behavioral Science, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.1111/bdi.12957DOI Listing

Testing the transdiagnostic hypothesis of inhibitory control deficits in addictions: An experimental study on gambling disorder.

J Behav Addict 2020 Jun 16. Epub 2020 Jun 16.

2 Department of Developmental and Social Psychology, University of Padova, Via Venezia, 8, I-35131, Padova, Italy.

Background And Aims: Many psychopathologies, including addictions, are characterized by inhibitory control deficits. In this regard, recent studies on substance-related disorders (SRD) have shown an impairment in the ability to inhibit potentially interfering memories, despite preserved motor inhibition. To investigate whether the same dissociation could also characterize gambling disorder (GD) in a transdiagnostic perspective, we tested both cognitive and motor inhibitory processes through dedicated tasks, for the first time in this behavioral addiction. Read More

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http://dx.doi.org/10.1556/2006.2020.00021DOI Listing

Interference of Dermatophagoides pteronyssinus sensitization in grass pollen allergy.

Eur Ann Allergy Clin Immunol 2020 06 17. Epub 2020 Jun 17.

Allergy Department, Complejo Hospitalario Universitario de Santiago, Faculty of Medicine, University of Santiago de Compostela, Santiago, Spain.

Background. Climate conditions in the northwest of Spain are from the rest of the country, and the pollen sensitisation rates and allergens involved are different. The present study aimed to investigate the sensitisation profile of patients with grass pollen allergy and the interference of other sensitisations in respiratory symptoms. Read More

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http://dx.doi.org/10.23822/EurAnnACI.1764-1489.159DOI Listing

Nicotine-induced adrenal beta-arrestin1 upregulation mediates tobacco-related hyperaldosteronism leading to cardiac dysfunction.

World J Cardiol 2020 May;12(5):192-202

Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences (Pharmacology), College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328-2018, United States.

Background: Tobacco-related products, containing the highly addictive nicotine together with numerous other harmful toxicants and carcinogens, have been clearly associated with coronary artery disease, heart failure, stroke, and other heart diseases. Among the mechanisms by which nicotine contributes to heart disease is elevation of the renin-angiotensin-aldosterone system (RAAS) activity. Nicotine, and its major metabolite in humans cotinine, have been reported to induce RAAS activation, resulting in aldosterone elevation in smokers. Read More

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http://dx.doi.org/10.4330/wjc.v12.i5.192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283997PMC

Validation of a nicotine vapor self-administration model in rats with relevance to electronic cigarette use.

Neuropsychopharmacology 2020 Jun 16. Epub 2020 Jun 16.

Department of Neuroscience, The Scripps Research Institute, 10550N. Torrey Pines Road, La Jolla, CA, USA.

The debate about electronic cigarettes is dividing healthcare professionals, policymakers, manufacturers, and communities. A key limitation in our understanding of the cause and consequences of vaping is the lack of animal models of nicotine vapor self-administration. Here, we developed a novel model of voluntary electronic cigarette use in rats using operant behavior. Read More

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http://dx.doi.org/10.1038/s41386-020-0734-8DOI Listing

Does physical activity associated with chronic food restriction alleviate anxiety like behaviour, in female mice?

Horm Behav 2020 Jul 9;124:104807. Epub 2020 Jul 9.

Université de Paris, Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266, "Vulnerability of Psychiatric and Addictive Disorders", F-75014 Paris, France; Department of Physiology/Endocrine, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, SE-405 30 Gothenburg, Sweden. Electronic address:

Anorexia nervosa (AN) is an eating disorder characterized by excessive weight loss, persistent food restriction and inappropriate physical activity relative to declining energy balance. The comorbidity with depression and/or anxiety disorders might contribute to the "chronicization" of the disease. We aimed here to question first the link between physical activity and anxiety from a clinical investigation of AN patients (n = 206). Read More

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http://dx.doi.org/10.1016/j.yhbeh.2020.104807DOI Listing

Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities.

Nat Rev Neurol 2020 Jul 15;16(7):381-400. Epub 2020 Jun 15.

Division of Translational Research, National Institute of Neurological Disorders and Stroke, NIH, Rockville, MD, USA.

Pain medication plays an important role in the treatment of acute and chronic pain conditions, but some drugs, opioids in particular, have been overprescribed or prescribed without adequate safeguards, leading to an alarming rise in medication-related overdose deaths. The NIH Helping to End Addiction Long-term (HEAL) Initiative is a trans-agency effort to provide scientific solutions to stem the opioid crisis. One component of the initiative is to support biomarker discovery and rigorous validation in collaboration with industry leaders to accelerate high-quality clinical research into neurotherapeutics and pain. Read More

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http://dx.doi.org/10.1038/s41582-020-0362-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326705PMC

A modulator of the low-voltage activated T-type calcium channel that reverses HIV glycoprotein 120-, paclitaxel-, and spinal nerve ligation-induced peripheral neuropathies.

Pain 2020 Jun 10. Epub 2020 Jun 10.

Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85721, United States.

The voltage-gated calcium channels CaV3.1-3.3 constitute the T-type subfamily, whose dysfunctions are associated with epilepsy, psychiatric disorders, and chronic pain. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001955DOI Listing
June 2020
5.213 Impact Factor

COVID-19 and addiction.

Diabetes Metab Syndr 2020 Jun 9;14(5):817-823. Epub 2020 Jun 9.

Department of Neuromedicine, Bangur Institute of Neurosciences, Institute of Post Graduate Medical Education and Research & SSKM Hospital, Kolkata, West Bengal, India. Electronic address:

Background And Aims: 2019-coronavirus disease (COVID-19) is causing insurmountable psychosocial impact on the whole mankind. Marginalized community, particularly those with substance use disorders (SUD), are particularly vulnerable to contract the infection and also likely to suffer from greater psychosocial burden. This article analyses the intricate bi-directional relationship between COVID-19 and addiction. Read More

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http://dx.doi.org/10.1016/j.dsx.2020.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282772PMC

Gambling motives: Association with addictive disorders and negative and positive mood in youth.

Addict Behav 2020 May 22;110:106482. Epub 2020 May 22.

Universidad de Deusto, Spain.

Gambling disorder and other comorbid addictive disorders may have similar underlying affective and motivational patterns. This study aims at examining the association between gambling disorder, comorbid addictive disorders (i.e. Read More

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http://dx.doi.org/10.1016/j.addbeh.2020.106482DOI Listing

Neurobiology of cue-reactivity, craving, and inhibitory control in non-substance addictive behaviors.

J Neurol Sci 2020 Aug 31;415:116952. Epub 2020 May 31.

Departments of Psychiatry, Neuroscience and Child Study, Yale University School of Medicine, New Haven, USA; Connecticut Council on Problem Gambling, Wethersfield, USA; Connecticut Mental Health Center, New Haven, USA. Electronic address:

Non-substance addictive behaviors may involve repetitive rewarding behaviors including gambling, gaming, sexual activities, internet-use, and buying-shopping. In addictions, there exists diminished control over participation in the behaviors and continuation of the behaviors despite experiencing negative consequences. Addictive participation in behaviors typically results in distress and functional impairment in personal, relational, occupational, educational, or other life domains. Read More

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http://dx.doi.org/10.1016/j.jns.2020.116952DOI Listing

Lisdexamfetamine alters BOLD-fMRI activations induced by odor cues in impulsive children.

CNS Neurol Disord Drug Targets 2020 Jun 13. Epub 2020 Jun 13.

Faculty of Mathematical and Physical Sciences, Benemérita Universidad Autónoma de Puebla (BUAP). Address: Avenida San Claudio y 18 Sur, Colonia San Manuel, Edificio FM1-101B, Ciudad Universitaria, C.P. 72570, Puebla. Mexico.

Introduction: Lisdexamfetamine (LDX) is a drug used to treat ADHD/impulsive patients. Impulsivity is known to affect inhibitory, emotional and cognitive function. On the other hand, smell and odor processing are known to be affected by neurological disorders, as they are modulators of addictive and impulsive behaviors specifically. Read More

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http://dx.doi.org/10.2174/1871527319666200613222502DOI Listing

E-cigarettes, nicotine, the lung and the brain: multi-level cascading pathophysiology.

J Physiol 2020 Jun 9. Epub 2020 Jun 9.

Department of Cell Biology & Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Tobacco smoking is highly addictive and causes respiratory disease, cardiovascular disease and multiple types of cancer. Electronic-cigarettes (e-cigarettes) are non-combustible tobacco alternatives that aerosolize nicotine and flavoring agents in a propylene glycol/vegetable glycerin (PG/VG) vehicle. They were originally envisaged as a tobacco cessation aid, but whether or not they help people to quit tobacco use is controversial. Read More

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http://dx.doi.org/10.1113/JP278388DOI Listing

Animal Models of the Behavioral Symptoms of Substance Use Disorders.

Cold Spring Harb Perspect Med 2020 Jun 8. Epub 2020 Jun 8.

Université de Bordeaux, Bordeaux Neurocampus, Institut des Maladies Neurodégénératives, CNRS UMR 5293, F-33000 Bordeaux, France.

To more effectively manage substance use disorders, it is imperative to understand the neural, genetic, and psychological underpinnings of addictive behavior. To contribute to this understanding, considerable efforts have been made to develop translational animal models that capture key behavioral characteristics of addiction on the basis of DSM5 criteria of substance use disorders. In this review, we summarize empirical evidence for the occurrence of addiction-like behavior in animals. Read More

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http://dx.doi.org/10.1101/cshperspect.a040287DOI Listing

The Impact of Community Disaster Trauma: A Focus on Emerging Research of PTSD and Other Mental Health Outcomes.

Chonnam Med J 2020 May 25;56(2):99-107. Epub 2020 May 25.

Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.

This paper reviews community residents' mental health following exposure to a community disaster trauma, with a focus on post-traumatic stress disorder (PTSD) and other mental health outcomes, such as emotional disorders, behavioral problems including addictive disorders, and personality as a maladaptive trait. This review concludes with recommendations to advance the field of community disaster research by exploring how natural and man-made disasters impact community residents across multiple domains. Moreover, this study suggests that residents impacted by community disaster trauma are frequently appropriate targets for mental health assessments or services in a community setting. Read More

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http://dx.doi.org/10.4068/cmj.2020.56.2.99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250671PMC

Does acute stress influence the Pavlovian-to-instrumental transfer effect? Implications for substance use disorders.

Psychopharmacology (Berl) 2020 Aug 6;237(8):2305-2316. Epub 2020 Jun 6.

Department of Cognitive Psychology, Ruhr University Bochum, Bochum, Germany.

Rational: The ability of conditioned stimuli to affect instrumental responding is a robust finding from animal as well as human research and is assumed as a key factor regarding the development and maintenance of addictive behaviour.

Objectives: While it is well known that stress is an important factor for relapse after treatment, little is known about the impact of stress on conditioned substance-associated stimuli and their influence on instrumental responding.

Methods: We administered in the present study a Pavlovian-to-instrumental transfer (PIT) paradigm with stimuli associated with smoking- and chocolate-related rewards using points in a token economy to light to moderate smokers who also indicated to like eating chocolate. Read More

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http://dx.doi.org/10.1007/s00213-020-05534-8DOI Listing

Brief Report: Increased Addictive Internet and Substance Use Behavior During the COVID-19 Pandemic in China.

Am J Addict 2020 07 4;29(4):268-270. Epub 2020 Jun 4.

National Institute on Drug Dependence, Peking University, Beijing, China.

Background And Objectives: The COVID-19 pandemic and control measures may have increased the risk of abusing addictive substances as well as addictive behaviors.

Methods: We present an initial online survey in 6416 Chinese about the relation between the COVID-19 pandemic and addictive behavior in China.

Results: During the COVID-19 pandemic, 46. Read More

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http://dx.doi.org/10.1111/ajad.13066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300868PMC