9,170 results match your criteria Addictive Disorders & Their Treatment[Journal]


Methamphetamine regulates βAPP PROCESSING in human neuroblastoma cells.

Neurosci Lett 2019 Feb 13. Epub 2019 Feb 13.

Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, 73170, Thailand; Centre National de la Recherche Scientifique, 2 rue Michel Ange, 75016, Paris, France. Electronic address:

Methamphetamine is a potent and highly addictive psychostimulant whose abuse has turned out to be a global health hazard. The multitudinous effects it exerts at the cellular level induces neurotoxic responses in the human brain, ultimately leading to neurocognitive disorders. Strikingly, brain changes, tissue damage and neuropsychological symptoms due to Meth exposure compels and necessitates to link the probability of risk of developing premature Alzheimer's disease, a progressive neurodegenerative disorder characterized by amyloid plaques composed of amyloid-β peptides and clinical dementia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2019.02.023DOI Listing
February 2019

Accelerated Hepatitis A and B Immunization in a Substance Abuse Treatment Program.

Fed Pract 2015 Aug;32(8):38-43

is a clinical psychologist, is an attending psychiatrist, is a clinical psychologist, is a retired licensed practical nurse, is a retired registered nurse, is a retired registered nurse, and is an attending psychiatrist, all at the James A. Haley Veterans' Hospital in Tampa, Florida. is an advanced registered nurse practitioner at American Lake Division of the VA Puget Sound Healthcare System in Lakewood, Washington. Dr. Winn is an assistant professor, Dr. Francis is an associate professor, Dr. Shealy is an assistant professor, and Dr. Gonzales-Nolas is an assistant professor, all at the University of South Florida in Tampa.

An accelerated dosing program for hepatitis A and B vaccination among veterans receiving treatment for addictive disorders was successfully implemented, although many veterans with hepatitis C did not complete the immunization series. Read More

View Article

Download full-text PDF

Source

Which Criteria to Use to Identify Metabolic Syndrome among Patients with Addictive Disorders? Observations among Patients with Alcohol and Opioid Dependence Syndrome.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):856

Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijem.IJEM_562_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330862PMC
February 2019

Paramedic and Emergency Medical Technician Reflections on the Ongoing Impact of the 9/11 Terrorist Attacks.

Prehosp Disaster Med 2019 Feb;34(1):56-61

3Harvard Humanitarian Initiative,Harvard University and Harvard T.C. Chan School of Public Health,Cambridge,MassachusettsUSA.

IntroductionIn the years following the September 11, 2001 terrorist attacks in New York City (New York USA), otherwise known as 9/11, first responders began experiencing a range of health and psychosocial impacts. Publications documenting these largely focus on firefighters. This research explores paramedic and emergency medical technician (EMT) reflections on the long-term impact of responding to the 9/11 terrorist attacks. Read More

View Article

Download full-text PDF

Source
https://www.cambridge.org/core/product/identifier/S1049023X1
Publisher Site
http://dx.doi.org/10.1017/S1049023X18001255DOI Listing
February 2019
1 Read

Psychological and psychopathological sequelae in cardiovascular acute disease.

Ment Illn 2018 Nov 5;10(2):7887. Epub 2018 Dec 5.

Center for Prevention and Care of the Tabagism, University-Hospital "Policlinico V. Emanuele", University of Catania, Italy; Department of Clinical and Experimental Biomedicine, University of Catania, Italy; Institute for Social Marketing, University of Stirling, UK.

The burden of mental illness is profound and growing. Each year, almost one in three adults in the non-institutionalized community has a diagnosable mental or addictive disorder, and this figure climbs to approximately 40% among emergency departments patients. We described the principal cardiovascular acute disease and their emotional and behavioral consequences where psychological intervention could improve the care pathway and clinical outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4081/mi.2018.7887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342026PMC
November 2018

Shared Neural Correlates Underlying Addictive Disorders and Negative Urgency.

Brain Sci 2019 Feb 8;9(2). Epub 2019 Feb 8.

Department of Psychology, Indiana University⁻Purdue University Indianapolis, Indianapolis, IN, 46202, USA.

Negative urgency is a personality trait reflecting the tendency to act rashly in response to extreme negative emotions and is considered a transdiagnostic endophenotype for problematic levels of addictive behaviors. Recent research has begun to identify the neural correlates of negative urgency, many of which appear to overlap with neural circuitry underlying addictive disorders associated with negative urgency. The goal of this qualitative review is to summarize the extant literature concerning the neural correlates of negative urgency, to compare these correlates with those implicated with addictive disorders, and to propose new ways to begin to leverage such findings in treatment and intervention approaches. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/brainsci9020036DOI Listing
February 2019
1 Read

Cardiovascular effects of alcohol: A double-edged sword / how to remain at the nadir point of the J-Curve?

Alcohol 2018 Aug 29;76:117-129. Epub 2018 Aug 29.

Third Department of Cardiology, Athens University School of Medicine, Athens, Greece. Electronic address:

Background: In addition to its established harmful effects on the liver and other organs, heavy alcohol use confers deleterious effects on the cardiovascular (CV) system, as well. However, data have emerged that light/moderate alcohol consumption (1 drink/day for women and 1-2 drinks/day for men) may be protective against CV disease.

Objective/methods: English articles regarding the CV effects of alcohol/ethanol were reviewed by search in Medline, Scopus, and Google Scholar. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.08.011DOI Listing

Dietary Energy Restriction Ameliorates Cognitive Impairment in a Mouse Model of Traumatic Brain Injury.

J Mol Neurosci 2019 Feb 8. Epub 2019 Feb 8.

Department of Anatomy and Anthropology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Traumatic brain injury (TBI) is one of the most common causes of neurological damage in young people. It was previously reported that dietary restriction, by either intermittent fasting (IF) or daily caloric restriction (CR), could protect neurons against dysfunction and degeneration in animal models of stroke and Parkinson's disease. Recently, several studies have shown that the protein Sirtuin 1 (SIRT1) plays a significant role in the induced neuroprotection following dietary restriction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12031-019-01271-6DOI Listing
February 2019
2 Reads

Global Burden of Disease and the Impact of Mental and Addictive Disorders.

Curr Psychiatry Rep 2019 Feb 7;21(2):10. Epub 2019 Feb 7.

Centre for Addiction and Mental Health, Institute for Mental Health Policy Research, 33 Russell Street, Toronto, Ontario, M5S 2S1, Canada.

Purpose Of Review: This contribution reviews the newest empirical evidence regarding the burden of mental and addictive disorders and weighs their importance for global health in the first decades of the twenty-first century.

Recent Findings: Mental and addictive disorders affected more than 1 billion people globally in 2016. They caused 7% of all global burden of disease as measured in DALYs and 19% of all years lived with disability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11920-019-0997-0DOI Listing
February 2019
1 Read

Enhancing the Quality and Utility of Content Analyses for Addictive Disorders.

Int J Environ Res Public Health 2018 Jul 2;15(7). Epub 2018 Jul 2.

Family Medicine and Primary Care, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore 308232, Singapore.

The advances in Mobile Health (M-health) technologies has led to an increase in the numbers of alcohol and drugs applications on the commercial stores. Content analyses and reviews of applications to date have demonstrated that most of these applications are for entertainment or information purposes. More recent content analyses have identified common behavioural change techniques in substance applications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph15071389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068796PMC
July 2018
1 Read

Repeated methamphetamine treatment increases spine density in the nucleus accumbens of serotonin transporter knockout mice.

Neuropsychopharmacol Rep 2019 Feb 4. Epub 2019 Feb 4.

Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan.

Aim: Repeated psychostimulant drug treatment, including methamphetamine, in rodents readily produces behavioral sensitization, which reflects altered brain function caused by repeated drug exposure. Dendritic remodeling of medium spiny neurons in the nucleus accumbens is thought to be an essential mechanism underlying behavioral sensitization. We recently showed that chronic methamphetamine treatment did not produce behavioral sensitization in serotonin transporter knockout mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/npr2.12049DOI Listing
February 2019

Low stress resilience in late adolescence and risk of smoking, high alcohol consumption and drug use later in life.

J Epidemiol Community Health 2019 Feb 4. Epub 2019 Feb 4.

Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden.

Background: While compromised stress resilience constitutes a recognised risk factor for somatic and psychiatric disease development in general, the knowledge about how individual variation in vulnerability to stress may specifically influence the long-term risks of disadvantageous health behaviours is limited.

Methods: In this Swedish cohort study, we aimed to investigate the association between stress resilience in late adolescence and adult use of addictive substances. We included 9381 men with information on psychological stress resilience measured during military conscription examinations, who later responded to an extensive health survey (mean age 34. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jech-2018-211815DOI Listing
February 2019

Magnesium in addiction - a general view.

Authors:
Mihai Nechifor

Magnes Res 2018 Aug;31(3):90-98

Department of Pharmacology "Gr. T. Popa" University of Medicine and Pharmacy, Iasi, Romania.

Addiction is a dysregulation of brain reward systems that progressively increases, resulting in compulsive drug use and loss of control over drug-taking. Addiction is a brain disease. There is evidence that magnesium deficit is involved in addiction to various addictive substances (heroin, morphine, cocaine, nicotine, alcohol, caffeine, and others). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/mrh.2018.0443DOI Listing
August 2018
2 Reads

Comparing opium tincture and methadone for medication-assisted treatment of patients with opioid use disorder: Protocol for a multicenter parallel group noninferiority double-blind randomized controlled trial.

Int J Methods Psychiatr Res 2019 Feb 4:e1768. Epub 2019 Feb 4.

Addiction and Concurrent Disorders Group, Institute of Mental Health, Centre for Health Evaluation and Outcome Sciences, Department of Psychiatry, University of British Columbia, Vancouver, Canada.

Objectives: This is the first study to compare the safety and efficacy of opium tincture (OT) with methadone for treatment of opioid use disorder.

Methods: In this multicenter, double-blind, noninferiority controlled trial, a stratified sample of 204 participants with opioid use disorder were recruited from community outreach, drop-in centers, and triangular clinics. Participants were excluded in case of active participation in another treatment program for opioid use disorder, hypersensitivity to trial medications, pregnancy, and certain serious medical conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mpr.1768DOI Listing
February 2019
3.759 Impact Factor

Unmasking neurobiological commonalities between addictive disorders and impulse control disorders in Parkinson's disease.

Brain Imaging Behav 2019 Feb 1. Epub 2019 Feb 1.

UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia.

Changes in reward circuitry have been studied extensively in substance and behavioural addictions. However, comparatively little is known about the neurobiology underlying impulse control disorders (ICDs) in Parkinson's disease, which show roughly similar risk factors and behavioural presentations to both stimulant and behavioural addictions. ICDs occur in a subset of susceptible patients with Parkinson's disease (PD) following intake of dopamine replacement therapy (DRT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11682-019-00041-7DOI Listing
February 2019

The Cognitive Drivers of Compulsive Eating Behavior.

Front Behav Neurosci 2018 17;12:338. Epub 2019 Jan 17.

Monash Institute for Cognitive and Clinical Neurosciences (MICCN), School of Psychological Sciences, Monash University, Melbourne, VIC, Australia.

Compulsivity is a central feature of obsessive-compulsive and addictive disorders, which share considerable overlap with excessive eating in terms of repetitive behavior despite negative consequences. Excessive eating behavior is characteristic of several eating-related conditions, including eating disorders [bulimia nervosa (BN), binge eating disorder (BED)], obesity, and food addiction (FA). Compulsivity is proposed to be driven by four distinct cognitive components, namely, contingency-related cognitive flexibility, task/attentional set-shifting, attentional bias/disengagement and habit learning. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnbeh.2018.00338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344462PMC
January 2019
1 Read

Methamphetamine and its immune-modulating effects.

Maturitas 2019 Mar 5;121:13-21. Epub 2018 Dec 5.

Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia. Electronic address:

The recreational use of methamphetamine (METH, or ice) is a global burden. It pervades and plagues contemporary society; it has been estimated that there are up to 35 million users worldwide. METH is a highly addictive psychotropic compound which acts on the central nervous system, and chronic use can induce psychotic behavior. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.maturitas.2018.12.003DOI Listing
March 2019
2 Reads
2.942 Impact Factor

Sodium Channels in Human Pain Disorders: Genetics and Pharmacogenomics.

Annu Rev Neurosci 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA; email:

Acute pain is adaptive, but chronic pain is a global challenge. Many chronic pain syndromes are peripheral in origin and reflect hyperactivity of peripheral pain-signaling neurons. Current treatments are ineffective or only partially effective and in some cases can be addictive, underscoring the need for better therapies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-neuro-070918-050144DOI Listing
January 2019

Acculturative stress and alcohol use among Latinx recruited from a primary care clinic: Moderations by emotion dysregulation.

Am J Orthopsychiatry 2019 Jan 31. Epub 2019 Jan 31.

Department of Psychology.

Among Latinx in the United States, alcohol is the most widely abused substance and is associated with a range of negative consequences. Acculturative stress is one factor that is relevant regarding Latinx substance use although more work is needed in this area. In theory, those with more adaptive emotion regulation capabilities may be better able to buffer against the adverse effects of acculturative stress on alcohol use because the person has more and better strategies to deal with life stress. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1037/ort0000378DOI Listing
January 2019

Oleoylethanolamide, Neuroinflammation, and Alcohol Abuse.

Front Mol Neurosci 2018 9;11:490. Epub 2019 Jan 9.

Department of Pharmacology and Toxicology, Faculty of Medicine, Complutense University of Madrid, Madrid, Spain.

Neuroinflammation is a complex process involved in the physiopathology of many central nervous system diseases, including addiction. Alcohol abuse is characterized by induction of peripheral inflammation and neuroinflammation, which hallmark is the activation of innate immunity toll-like receptors 4 (TLR4). In the last years, lipid transmitters have generated attention as modulators of parts of the addictive process. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fnmol.2018.00490
Publisher Site
http://dx.doi.org/10.3389/fnmol.2018.00490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333756PMC
January 2019
2 Reads

Reconsolidation impairment of reward memory by stimulating stress response.

Addict Biol 2019 Jan 22. Epub 2019 Jan 22.

Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany.

Research in memory reconsolidation has raised hope for new treatment options of persistent psychiatric disorders like substance dependence and post-traumatic stress disorder (PTSD). While animal research showed successful memory modification by interfering with reconsolidation, human research requires less invasive techniques. In our pilot study, we aimed to reduce appetitive memory reconsolidation of a newly acquired reward memory by exerting a stressor. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/adb.12712
Publisher Site
http://dx.doi.org/10.1111/adb.12712DOI Listing
January 2019
4 Reads

Prescription opioid misuse and the need to promote medication safety among adolescents.

Res Social Adm Pharm 2019 Jan 11. Epub 2019 Jan 11.

Department of Family Medicine and Community Health, School of Medicine and Public Health, University of Wisconsin-Madison, USA; Center for Addictive Disorders, UW Hospitals & Clinics, USA.

Misuse of prescription opioids and associated negative health outcomes is a leading public health crisis among adolescents in the US. Opioid prescription rates, misuse, and overdose deaths have increased among adolescents in the last twenty years. This commentary highlights trends in prescribing opioids and medication misuse among adolescents in the US and sheds light on reasons and motives for misuse of prescription opioids among adolescents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sapharm.2019.01.003DOI Listing
January 2019
3 Reads

Brain Change in Addiction as Learning, Not Disease.

N Engl J Med 2019 01;380(3):301

UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1815144DOI Listing
January 2019
4 Reads

Brain Change in Addiction as Learning, Not Disease.

N Engl J Med 2019 01;380(3):301

Johns Hopkins University School of Medicine, Baltimore, MD

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1815144DOI Listing
January 2019
6 Reads

Functional and structural neuroimaging studies of delayed reward discounting in addiction: A systematic review.

Psychol Bull 2019 Feb;145(2):141-164

Peter Boris Centre for Addiction Research, St. Joseph's Healthcare Hamilton, McMaster University.

Given the robust behavioral association between delayed reward discounting (DRD) and addictive behavior, there is an expanding literature investigating the neural correlates of this relationship. The objective of this systematic review was to characterize and critically appraise the existing literature examining the neural correlates of DRD in individuals exhibiting addictive behavior using functional and structural MRI (fMRI/MRI) and to do so through the lens of the neural networks implicated in addiction. Using a systematic search strategy, 20 studies were identified, with 12 focusing on task fMRI, 4 focusing on functional connectivity fMRI, and 4 focusing on structural MRI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1037/bul0000181DOI Listing
February 2019
9 Reads

Brain Change in Addiction as Learning, Not Disease.

Authors:
Marc Lewis

N Engl J Med 2019 01;380(3):301-302

University of Toronto, Toronto, ON, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1815144DOI Listing
January 2019
3 Reads

Mephedrone impact on matrix metalloproteinases activity - do they influence the memory processes?

Curr Mol Pharmacol 2019 Jan 14. Epub 2019 Jan 14.

Laboratory of Behavioral Research, Jaczewskiego 8d Str., Medical University of Lublin, Lublin. Poland.

Background: The use of drugs of addiction, as mephedrone, is associated with functional neuronal disorders due to remodeling of the nervous tissue. Key enzymes in remodeling are extracellular matrix (ECM) proteases like matrix metalloproteases (MMPs). Recently, MMPs have been of great interest as some studies point to a fact that the alterations in structural remodeling of synaptic connections modify learning-dependent changes, which remain active even after a prolonged period of abstinence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874467212666190114154307DOI Listing
January 2019
3 Reads

Cognitive Bias Modification for Behavior Change in Alcohol and Smoking Addiction: Bayesian Meta-Analysis of Individual Participant Data.

Neuropsychol Rev 2019 Jan 14. Epub 2019 Jan 14.

Department of Psychology, University of Amsterdam, Nieuwe Achtergracht 129B, 1018, Amsterdam, WS, Netherlands.

Cognitive Bias Modification (CBM) refers to a family of interventions targeting substance-related cognitive biases, which have been found to play a role in the maintenance of addictive behaviors. In this study, we conducted a Bayesian meta-analysis of individual patient data from studies investigating the effects of CBM as a behavior change intervention for the treatment of alcohol and tobacco use disorders, in individuals aware of the behavior change goal of the studies. Main outcomes included reduction in the targeted cognitive biases after the intervention and in substance use or relapse rate at the short-to-long term follow-up. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11065-018-9386-4
Publisher Site
http://dx.doi.org/10.1007/s11065-018-9386-4DOI Listing
January 2019
4 Reads

Adulthood and childhood ADHD in patients consulting for obesity is associated with food addiction and binge eating, but not sleep apnea syndrome.

Appetite 2019 Jan 11;136:25-32. Epub 2019 Jan 11.

CHRU de Tours, Équipe de Liaison et de Soins en Addictologie & Clinique Psychiatrique Universitaire, 2 boulevard Tonnellé, 37044, Tours Cedex 9, France; Université de Tours, INSERM U1253 iBrain « Brain and Imaging », 2 boulevard Tonnellé, 37044, Tours Cedex, France. Electronic address:

Introduction: The exact mechanisms underlying the established association between ADHD and obesity remain unclear. Food addiction and binge eating may contribute to this link. We examined for the first time the association between childhood/adult ADHD and food addiction/binge eating in patients with obesity, as well as the association between ADHD and sleep apnea syndrome. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01956663183130
Publisher Site
http://dx.doi.org/10.1016/j.appet.2019.01.013DOI Listing
January 2019
5 Reads

Addicted to Facebook? Relationship between Facebook Addiction Disorder, duration of Facebook use and narcissism in an inpatient sample.

Psychiatry Res 2019 Jan 6;273:52-57. Epub 2019 Jan 6.

Department of Psychosomatic Medicine, Rehabilitation Center Seehof, Federal German Pension Agency, and Psychosomatic Rehabilitation Research Group, Charité - Universitätsmedizin Berlin, Germany.

The present study explored the Facebook Addiction Disorder (FAD) in an inpatient sample in Germany. Of the 112 Facebook users (71.4% women; age(years): M (SD) = 49. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psychres.2019.01.016DOI Listing
January 2019
5 Reads

Longitudinal changes in cocaine intake and cognition are linked to cortical thickness adaptations in cocaine users.

Neuroimage Clin 2019 Jan 4:101652. Epub 2019 Jan 4.

Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich, Switzerland. Electronic address:

Background: Cocaine use has been consistently associated with decreased gray matter volumes in the prefrontal cortex. However, it is unclear if such neuroanatomical abnormalities depict either pre-existing vulnerability markers or drug-induced consequences. Thus, this longitudinal MRI study investigated neuroplasticity and cognitive changes in relation to altered cocaine intake. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nicl.2019.101652DOI Listing
January 2019
4 Reads

Precision Psychiatry and Dual Disorders.

J Dual Diagn 2019 Jan 14:1-10. Epub 2019 Jan 14.

b Research Unit and Dual Disorders Program, Centre Neuchâtelois de Psychiatrie (CNP) , Neuchâtel , Switzerland.

Objective: Addiction co-occurs with distinct pathological personality traits, other psychiatric disorders or symptoms and cognitive impairment, which are known as dual disorders or co-occurring disorders. This symptomatic high concurrency suggests that both conditions are in some ways causally linked. Research is ongoing to identify distinctive neurobehavioral mechanisms and endophenotypes that predispose individuals to compulsive drug use and other mental disorders. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/15504263.2018.1
Publisher Site
http://dx.doi.org/10.1080/15504263.2018.1512727DOI Listing
January 2019
6 Reads

Effectiveness of a telephone-based intervention for smoking cessation in patients with severe mental disorders: study protocol for a randomized controlled trial.

Trials 2019 Jan 11;20(1):38. Epub 2019 Jan 11.

Tobacco Control Unit, Cancer Control and Prevention Program, Institut Català d'Oncologia-ICO, Av. Granvia de L'Hospitalet 199-203, L'Hospitalet de Llobregat, 08908, Barcelona, Spain.

Background: Up to 75% of inpatients with mental disorders smoke, and their life expectancy is decreased by up to 25 years compared to the general population. Hospitalized patients without monitoring after discharge quickly return to prehospitalization levels of tobacco use. The aim of the 061 QuitMental study is to assess the effectiveness of a multicomponent and motivational telephone-based intervention to stop smoking through a quitline addressed to smokers discharged from mental health hospital wards. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-018-3106-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329054PMC
January 2019
2 Reads

Development and evaluation of a novel kappa opioid receptor agonist as PET radiotracer with superior imaging characteristics.

J Nucl Med 2019 Jan 10. Epub 2019 Jan 10.

Yale University School of Medicine, United States.

Studies have shown kappa opioid receptor (KOR) abnormalities in addictive disorders and other central nervous system diseases and Alzheimer's disease. We have developed the first set of agonist C-GR103545 and antagonist C-LY2795050 radiotracers for positron emission tomography imaging of KOR in human. Nonetheless, C-GR103545 displays protracted uptake kinetics and is not an optimal radiotracer. Read More

View Article

Download full-text PDF

Source
http://jnm.snmjournals.org/lookup/doi/10.2967/jnumed.118.220
Publisher Site
http://dx.doi.org/10.2967/jnumed.118.220517DOI Listing
January 2019
13 Reads

The Effects of Oxytocin on Withdrawal, Craving and Stress Response in Heroin-Dependent Patients: A Randomized, Double-Blind Clinical Trial.

Eur Addict Res 2019 10;25(1):41-47. Epub 2019 Jan 10.

Department of Addiction Studies, School of Medicine, Kashan University of Medical Sciences, Kashan,

Opioid dependence is an increasing clinical and public health problem. Current pharmacotherapies have limited efficacy and cause serious side effects. Increasing bodies of evidences suggest the neuropeptide, oxytocin (OT), as a potential treatment for drug abuse disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496194DOI Listing
January 2019
5 Reads

Excessive social media users demonstrate impaired decision making in the Iowa Gambling Task.

J Behav Addict 2019 Jan 9:1-5. Epub 2019 Jan 9.

5 School of Psychological Sciences, Monash Institute of Cognitive and Clinical Neurosciences, Monash University , Melbourne, VIC, Australia.

Background And Aims: Online social networking sites (SNSs) like Facebook provide users with myriad social rewards. These social rewards bring users back to SNSs repeatedly, with some users displaying maladaptive, excessive SNS use. Symptoms of this excessive SNS use are similar to symptoms of substance use and behavioral addictive disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1556/2006.7.2018.138DOI Listing
January 2019
11 Reads

Substance Abuse-Related Self-Stigma in Women with Substance Use Disorder and Comorbid Posttraumatic Stress Disorder.

Eur Addict Res 2019 9;25(1):20-29. Epub 2019 Jan 9.

Center for Interdisciplinary Addiction Research, University of Hamburg, Hamburg, Germany.

Background: Self-stigma is a result of internalizing negative stereotypes by the affected person. Research on self-stigma in substance use disorders (SUD) is still scarce, especially regarding the role of childhood trauma and subsequent posttraumatic disorders.

Objectives: The present study investigated the progressive model of self-stigma in women with SUD and posttraumatic stress disorder (PTSD), and the predictive value of PTSD severity and childhood trauma experiences on self-stigma. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/496113
Publisher Site
http://dx.doi.org/10.1159/000496113DOI Listing
January 2019
8 Reads

Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero.

Mol Brain 2019 01 8;12(1). Epub 2019 Jan 8.

Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, Japan.

The mammalian target of rapamycin (mTOR) signaling pathway plays a crucial role in cell metabolism, growth, and proliferation. The overactivation of mTOR has been implicated in the pathogenesis of syndromic autism spectrum disorder (ASD), such as tuberous sclerosis complex (TSC). Treatment with the mTOR inhibitor rapamycin improved social interaction deficits in mouse models of TSC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13041-018-0423-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325753PMC
January 2019
2 Reads

Vitamin B12 Levels in Methamphetamine Addicts.

Front Behav Neurosci 2018 18;12:320. Epub 2018 Dec 18.

Department of Psychiatry, Bengbu Medical College, Bengbu, China.

It has been established that reduced vitamin B12 serum levels are associated with cognitive decline and mental illness. The chronic use of methamphetamine (MA), which is a highly addictive drug, can induce cognitive impairment and psychopathological symptoms. There are few studies addressing the association of MA with vitamin B12 serum levels. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fnbeh.2018.00320
Publisher Site
http://dx.doi.org/10.3389/fnbeh.2018.00320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305445PMC
December 2018
7 Reads

Rising trend of substance abuse in Pakistan: a study of sociodemographic profiles of patients admitted to rehabilitation centres.

Authors:
P Ghazal

Public Health 2019 Feb 4;167:34-37. Epub 2019 Jan 4.

Department of Biosciences, COMSATS, Institute of Information Technology, Islamabad, Pakistan. Electronic address:

Objectives: In Pakistan, the prevalence of drug addiction is increasing at an alarming rate. However, the risk factors, which are increasing vulnerability towards addiction, remain largely elusive. The major objective of this investigation was to study the sociodemographic variables common in addicted patients in order to identify vulnerable cohorts and risk factors, which increase predisposition towards substance abuse. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00333506183034
Publisher Site
http://dx.doi.org/10.1016/j.puhe.2018.10.020DOI Listing
February 2019
5 Reads

Development and validation of the compulsive-buying follow-up scale: A measure to assess treatment improvements in compulsive buying disorder.

Psychiatry Res 2018 Dec 31. Epub 2018 Dec 31.

Impulse Control Disorders Outpatient Unit, Institute of Psychiatry, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo (SP). Brazil.

The aim of the present research was to develop a scale to assess treatment improvements for compulsive buying disorder (CBD), adapted from the Gambling Follow-up Scale Self-Report Version. The Compulsive Buying Follow-up Scale (CBFS) contains six self-report multiple-choice items assessing different aspects of compulsive buying in the past four weeks. Forty-eight treatment-seeking patients with CBD were evaluated, with 39 patients completing the 12-week follow-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psychres.2018.12.078DOI Listing
December 2018
3 Reads

The Cerebellum, THC, and Cannabis Addiction: Findings from Animal and Human Studies.

Cerebellum 2019 Jan 4. Epub 2019 Jan 4.

Pharmacy El Toro, La Fuente 11, 12429, El Toro, Castellon, Spain.

Cannabis is the third most used psychoactive drug worldwide. Despite being legally scheduled as a drug with high harm potential and no therapeutic utility in countries like the USA, evidence shows otherwise and legislative changes and reinterpretations of existing ambiguous laws make this drug increasingly available by legal means. Nevertheless, this substance is able to generate clear addiction syndromes in some individuals who use it, which are accompanied by brain alterations resembling those caused by other addictive drugs. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12311-018-0993-7
Publisher Site
http://dx.doi.org/10.1007/s12311-018-0993-7DOI Listing
January 2019
6 Reads

A positive association between a polymorphism in the HTR2B gene and cocaine-crack in a French Afro-Caribbean population.

World J Biol Psychiatry 2019 Jan 4:1-6. Epub 2019 Jan 4.

j Department of Psychiatry and Addictive Disorders , University Sorbonne Paris-Cité (Faculty of Medicine Paris Descartes), INSERM UMR 894-Team1 Center of Psychiatry and Neuroscience, University Hospital Cochin (site Tarnier) , Paris , France.

Objectives: Cocaine dependence has a strong heritability component. The aim of this study was to investigate the putative association between the serotonin 2B receptor gene (HTR2B), crack use disorders and impulsivity.

Methods: A French Afro-Caribbean male population of patients with crack use disorders (n = 80) was compared to healthy Afro-Caribbean male controls (n = 60). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15622975.2018.1563721DOI Listing
January 2019
2 Reads
4.183 Impact Factor

Neurofunctional Domains Derived From Deep Behavioral Phenotyping in Alcohol Use Disorder.

Am J Psychiatry 2019 Jan 4:appiajp201818030357. Epub 2019 Jan 4.

Office of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda (Kwako, Schwandt, Diazgranados, Goldman); Section on Human Psychopharmacology, NIAAA, Bethesda (Ramchandani); Office of the Director, NIAAA, Bethesda (Koob); Office of the Director, NIDA, Bethesda (Volkow); Division of Epidemiology, Services, and Prevention, NIDA, Bethesda (Blanco); and Laboratory of Neurogenetics, NIAAA, Bethesda (Goldman).

Objective:: The authors evaluated whether three neurofunctional domains proposed to be critical in the addiction cycle, namely, incentive salience, negative emotionality, and executive function, could be identified through factor analysis of a deeply phenotyped clinical sample.

Methods:: Clinical, behavioral, and self-report measures of addiction, personality, cognition, behavior, and exposure to early-life stress were collected as part of a screening and natural history study of alcohol use disorders in 454 individuals representing the spectrum of alcohol use and use disorders. The multiple indicators, multiple causes (MIMIC) approach was used to identify significant predictors of the latent factors identified by the analysis. Read More

View Article

Download full-text PDF

Source
http://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2018.18
Publisher Site
http://dx.doi.org/10.1176/appi.ajp.2018.18030357DOI Listing
January 2019
5 Reads

[Similarities between obesity and substance abuse disorder].

Authors:
Diego Tripodi

Vertex 2018 Mar;29(138):128-132

Hospital José T. Borda.

Obesity and its complications are one of the biggest problems that a clinician faces today. The vast majority of the treatments implemented have low effcacy, and obesity becomes diffcult to manage. In the last decades, obesity prevalence has doubled. Read More

View Article

Download full-text PDF

Source
March 2018
5 Reads

Tobacco Smoking: Risk to Develop Addiction, Chronic Obstructive Pulmonary Disease, and Lung Cancer.

Recent Pat Anticancer Drug Discov 2019 Jan 2. Epub 2019 Jan 2.

Clinical and Molecular Epidemiology, IRCSS San Raffaele Pisana, Via di Valcannuta 247, I-00166 Rome. Italy.

Background: The morbidity and mortality associated with tobacco smoking is well established. Nicotine is the addictive component of tobacco. Nicotine, through non-neuronal 7nicotinic receptor, induces cell proliferation, neo-angiogenesis, epithelial to mesenchymal transition, and inhibits drug-induced apoptosis. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/168708/article
Publisher Site
http://dx.doi.org/10.2174/1574892814666190102122848DOI Listing
January 2019
10 Reads

Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development.

Chronic Dis Transl Med 2018 Dec 18;4(4):211-224. Epub 2018 Dec 18.

Nutrition and Cancer Biology Laboratory, Jean-Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.

Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. The incidence of hepatocellular carcinoma (HCC) is increasing in the United States, and chronic, excessive alcohol consumption is responsible for 32%-45% of all the liver cancer cases in the United States. Avoidance of chronic or excessive alcohol intake is the best protection against alcohol-related liver injury; however, the social presence and addictive power of alcohol are strong. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cdtm.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308920PMC
December 2018
1 Read

On Being the "Right" Kind of Chronic Pain Patient.

Authors:
Caroline J Huang

Narrat Inq Bioeth 2018 ;8(3):239-245

The intertwined themes that emerge from these passionately told narratives demonstrate how difficult it can be to navigate chronic pain. Many authors describe the labor of living in chronic pain, and several refer to their use of opioid medication as a tool to facilitate participation. The relationship between tolerance, dependence, and addiction is touched on in a handful of narratives, with some authors confronting-and seemingly internalizing-the stigma of addiction in seeking to regulate their opioid use. Read More

View Article

Download full-text PDF

Source
https://muse.jhu.edu/article/712015
Publisher Site
http://dx.doi.org/10.1353/nib.2018.0073DOI Listing
January 2019
10 Reads

No One Should Have to Prove Their Worth to Get Medical Care, Regardless of Addiction or Pain.

Authors:
Maia Szalavitz

Narrat Inq Bioeth 2018 ;8(3):233-237

Comparing pain and addiction stories provides a unique insight into the way these issues are seen through different moral lenses. Addiction stories are tales of sin and redemption, while pain narratives focus on suffering and worthiness of care. In order to improve ethical treatment of both conditions, we cannot continue to see addiction as immorality and patient abandonment or criminalization as an acceptable approach to it. Read More

View Article

Download full-text PDF

Source
https://muse.jhu.edu/article/712014
Publisher Site
http://dx.doi.org/10.1353/nib.2018.0072DOI Listing
January 2019
6 Reads

Transforming brain signals related to value evaluation and self-control into behavioral choices.

Hum Brain Mapp 2019 Mar 28;40(4):1049-1061. Epub 2018 Dec 28.

Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science & Technology of China, Hefei, China.

The processes involved in value evaluation and self-control are critical when making behavioral choices. However, the evidence linking these two types of processes to behavioral choices in intertemporal decision-making remains elusive. As the ventromedial prefrontal cortex (vmPFC), striatum, and dorsolateral prefrontal cortex (dlPFC) have been associated with these two processes, we focused on these three regions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hbm.24379DOI Listing
March 2019
2 Reads
5.969 Impact Factor