7,984 results match your criteria Addiction science & clinical practice[Journal]


Intervention Effects of Motivation Interviewing Chinese Modified on the Mental Health of College Students with Exercise Dependence.

Psychiatr Q 2019 Apr 18. Epub 2019 Apr 18.

Physical Education Institute, Hunan First Normal University, NO.1015, The Third Fenglin Road, Changsha, 410205, China.

Exercise dependence is a psychological problem that cannot be ignored and is positively related to anxiety and depression of college students. However, only a few effective intervention methods are available to deal with exercise dependence. This study aims to investigate the intervention effects of motivation interviewing Chinese modified on the mental health of college students with exercise dependence. Read More

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http://dx.doi.org/10.1007/s11126-019-09635-2DOI Listing

Factors associated with alcohol consumption and prescribed drugs with addiction potential among older women and men - the Nord-Trøndelag health study (HUNT2 and HUNT3), Norway, a population-based longitudinal study.

BMC Geriatr 2019 Apr 18;19(1):113. Epub 2019 Apr 18.

Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.

Background: Little is known about factors associated with alcohol consumption and use of drugs with addiction potential in older adults. The aim of this study was to explore the association between socio-demographic variables, physical and mental health and the later (11 years) use of frequent drinking, prescribed drugs with addiction potential and the possible combination of frequent drinking and being prescribed drugs with addiction potential in older adults (≥ 65 years).

Methods: In this longitudinal study, we used data from two surveys of the Nord-Trøndelag Health Study (HUNT2 1995-1997 and HUNT3 2006-2008), a population based study in Norway. Read More

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https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877
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http://dx.doi.org/10.1186/s12877-019-1114-2DOI Listing
April 2019
1 Read

[Chronic phosphoproteomic in temporal lobe epilepsy mouse models induced by kainic acid].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):197-205

Institute of Systems Biomedicine, State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Science, Beijing 100191, China.

Objective: To investigate functions of proteins and signaling pathways involved in epileptogenesis during the chronic stage of temporal lobe epilepsy in mouse models.

Methods: Kainic acid-induced temporal lobe epilepsy models were conducted, when reaching stage 4 using racine scale, the mice of experimental group were supposed to be successfully established. Pentobarbital sodium was injected to stop epileptic seizure in case of death. Read More

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April 2019
3 Reads

Physical activity and fitness among pediatric cancer survivors: a meta-analysis of observational studies.

Support Care Cancer 2019 Apr 16. Epub 2019 Apr 16.

Division of Pediatric Hematology and Oncology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.

Purpose: The number of pediatric cancer survivors has increased dramatically over recent decades. Prior studies involving pediatric cancer survivors have reported reduced physical activity and fitness levels. Thus, the aim of this meta-analysis was to synthesize previous findings on physical activity and fitness levels of pediatric cancer survivors, who had completed cancer treatment and are in complete remission compared with age-matched, non-athletic healthy controls with no history of cancer diagnosis. Read More

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http://dx.doi.org/10.1007/s00520-019-04788-zDOI Listing

Intrinsic insular-frontal networks predict future nicotine dependence severity.

J Neurosci 2019 Apr 16. Epub 2019 Apr 16.

Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, 251 Bayview Blvd, Baltimore, MD, 21224

Although 60% of the US population have tried smoking cigarettes, only 16% smoke regularly. Identifying this susceptible subset of the population before the onset of nicotine dependence may encourage targeted early interventions to prevent regular smoking and/or minimize severity. While prospective neuroimaging in human populations can be challenging, preclinical neuroimaging models prior to chronic nicotine administration can help develop translational biomarkers of disease risk. Read More

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http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.0140-1
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http://dx.doi.org/10.1523/JNEUROSCI.0140-19.2019DOI Listing
April 2019
1 Read

Flexible assertive community treatment for individuals with a mild intellectual disability or borderline intellectual functioning: results of a longitudinal study in the Netherlands.

J Intellect Disabil Res 2019 Apr 16. Epub 2019 Apr 16.

Behavioural Science Institute (BSI), Radboud University, Nijmegen, the Netherlands & Trajectum, Zwolle, the Netherlands.

Background: Assertive community treatment (ACT) and Flexible assertive community treatment (FACT) are organisation models for intensive assertive outreach that were originally developed for individuals with severe mental illness. The models are increasingly applied to people with mild intellectual disability (MID) or borderline intellectual functioning (BIF) and challenging behaviour or mental illness. Research on these types of care for this population is limited. Read More

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http://dx.doi.org/10.1111/jir.12619DOI Listing

The effect of N-acetylcysteine and working memory training on neural mechanisms of working memory and cue reactivity in regular cocaine users.

Psychiatry Res Neuroimaging 2019 Apr 5;287:56-59. Epub 2019 Apr 5.

Addiction, Development, and Psychopathology (ADAPT) lab, Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands.

The current study investigated the combined effects of N-acetylcysteine and working memory (WM) training on behavioral and neural mechanisms of cue reactivity and WM in cocaine users in a randomized, double-blind design. Twenty-four of 38 cocaine-using men completed a 25-day treatment with either 2400 mg/day NAC or placebo. Both groups performed WM-training. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2019.03.011DOI Listing

Mortality in older adults with frequent alcohol consumption and use of drugs with addiction potential - The Nord Trøndelag Health Study 2006-2008 (HUNT3), Norway, a population-based study.

PLoS One 2019 16;14(4):e0214813. Epub 2019 Apr 16.

Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.

Background: The aim of this study was to investigate whether frequent drinking, use of drugs with addiction potential and the possible combination of frequent drinking and use of prescribed drugs with addiction potential were associated with all-cause mortality in older adults.

Methods: We used data from the Nord-Trøndelag Health Study (HUNT3 2006-08), a population-based study in Norway. A total of 11,545 (6,084 women) individuals 65 years and older at baseline participated. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214813PLOS

Relationships between Internet addiction and clinicodemographic and behavioral factors.

Neuropsychiatr Dis Treat 2019 26;15:739-752. Epub 2019 Mar 26.

Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan,

Backgrounds And Aims: While the Internet became an indispensable component of our contemporary life, public and academic attention is also gathered to its negative impact, namely Internet addiction (IA). Although clinicodemographic and behavioral factors are hypothetically implicated in the mechanism of IA, it still remains largely unknown how such factors are linked to IA severity. Thus, this study sought to examine relationships among IA severity and factors potentially associated with IA in Japanese students in different educational stages. Read More

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http://dx.doi.org/10.2147/NDT.S193357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440534PMC

Causes of death among homeless people: a population-based cross-sectional study of linked hospitalisation and mortality data in England.

Wellcome Open Res 2019 11;4:49. Epub 2019 Mar 11.

Collaborative Centre for Inclusion Health, Institute of Epidemiology & Health Care, University College London, London, NW1 2DA, UK.

: Homelessness has increased by 165% since 2010 in England, with evidence from many settings that those affected experience high levels of mortality. In this paper we examine the contribution of different causes of death to overall mortality in homeless people recently admitted to hospitals in England with specialist integrated homeless health and care (SIHHC) schemes.  : We undertook an analysis of linked hospital admission records and mortality data for people attending any one of 17 SIHHC schemes between 1st November 2013 and 30th November 2016. Read More

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http://dx.doi.org/10.12688/wellcomeopenres.15151.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449792PMC

Identification of a Functional Non-coding Variant in the GABA Receptor α2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research.

Front Genet 2019 29;10:188. Epub 2019 Mar 29.

Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.

GABA type-A (GABA-A) receptors containing the α2 subunit (GABRA2) are expressed in most brain regions and are critical in modulating inhibitory synaptic function. Genetic variation at the locus has been implicated in epilepsy, affective and psychiatric disorders, alcoholism and drug abuse. expression varies as a function of genotype and is modulated by sequence variants in several brain structures and populations, including F2 crosses originating from C57BL/6J (B6J) and the BXD recombinant inbred family derived from B6J and DBA/2J. Read More

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http://dx.doi.org/10.3389/fgene.2019.00188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449455PMC

The impact of expanded Medicaid eligibility on access to naloxone.

Addiction 2019 Apr 14. Epub 2019 Apr 14.

Doctoral Candidate in Health Policy, Harvard Graduate School of Arts and Science, 14 Story St. 4th Floor, Cambridge, MA, 02138.

Background And Aims: Federal, state, and local US governments have sought interventions to reduce deaths due to opioid overdoses, by increasing the availability of naloxone. The Affordable Care Act (ACA) expanded Medicaid coverage to low-income, childless adults, potentially giving this group financial access to naloxone. The aims of this paper are: 1) to describe the changes in the amount of Medicaid-covered naloxone used between 2009 and 2016 and 2) to quantify the differential change in the amount of dispensed naloxone between states that expanded their Medicaid programs and states that did not. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/add.14634
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http://dx.doi.org/10.1111/add.14634DOI Listing
April 2019
6 Reads

Cigarette smoke reduces short chain fatty acid production by a Porphyromonas gingivalis clinical isolate.

J Periodontal Res 2019 Apr 14. Epub 2019 Apr 14.

Departments of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, Kentucky.

Objectives: We hypothesized that short chain fatty acid (SCFA) production by oral pathogens is suppressed by exposure to cigarette smoke extract (CSE).

Background: Tobacco smoking is a major risk factor for plaque-induced periodontal diseases. Despite increased disease susceptibility, overt oral inflammation is suppressed in smokers, presenting a diagnostic conundrum. Read More

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http://dx.doi.org/10.1111/jre.12660DOI Listing
April 2019
1 Read

Acute Alcohol and Cognition: Remembering What It Causes Us to Forget.

Alcohol 2019 Apr 11. Epub 2019 Apr 11.

Division of Psychology, University of Wisconsin - Eau Claire, Eau Claire, WI 54702. Electronic address:

Addiction has been conceptualized as a specific form of memory that appropriates typically adaptive neural mechanisms of learning to produce the progressive spiral of drug-seeking and drug-taking behavior, perpetuating the path to addiction through aberrant processes of drug-related learning and memory. From that perspective, to understand the development of alcohol use disorders it is critical to identify how a single exposure to alcohol enters into or alters the processes of learning and memory, so that involvement of and changes in neuroplasticity processes responsible for learning and memory can be identified early on. This review characterizes the effects produced by acute alcohol intoxication as a function of brain region and memory neurocircuitry. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07418329193003
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http://dx.doi.org/10.1016/j.alcohol.2019.03.006DOI Listing
April 2019
3 Reads

Riluzole blocks HU210-facilitated ventral tegmental long-term depression by enhancing glutamate uptake in astrocytes.

Neurosci Lett 2019 Apr 9;704:201-207. Epub 2019 Apr 9.

Department of Neurology, Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, China. Electronic address:

The lifetime prevalence of addiction to cannabis (marijuana or cannabinoids) is among the highest of that of all illicit drugs in developed countries, and no effective treatment for cannabis addiction is currently available. Previous studies in our research group suggested that astrocyte-mediated long-term depression (LTD) in ventral tegmental area (VTA) dopamine neurons plays a pivotal role in the development of cannabis addiction. The present study was designed to investigate the effects and potential mechanisms of riluzole, a drug used for the treatment of motor neuron diseases, on cannabinoid-facilitated LTD induction. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.021DOI Listing
April 2019
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Commentary on Gravely et al (2019): Beginning a new era of nicotine products-beyond the four national-level determinants of nicotine vaping products (NVPs) use.

Authors:
Takahiro Tabuchi

Addiction 2019 Apr 11. Epub 2019 Apr 11.

Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan.

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http://dx.doi.org/10.1111/add.14611DOI Listing
April 2019
1 Read

Acute Cocaine Enhances Dopamine DR Recognition and Signaling and Counteracts DR Internalization in Sigma1R-DR Heteroreceptor Complexes.

Mol Neurobiol 2019 Apr 10. Epub 2019 Apr 10.

Department of Neuroscience, Karolinska Institutet, Biomedicum (B0851). Solnavägen 9, 171 77, Stockholm, Sweden.

The current study was performed to establish the actions of nanomolar concentrations of cocaine, not blocking the dopamine transporter, on dopamine D2 receptor (DR)-sigma 1 receptor (δ1R) heteroreceptor complexes and the DR protomer recognition, signaling and internalization in cellular models. We report the existence of DR-δ1R heteroreceptor complexes in subcortical limbic areas as well as the dorsal striatum, with different distribution patterns using the in situ proximity ligation assay. Also, through BRET, these heteromers were demonstrated in HEK293 cells. Read More

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http://dx.doi.org/10.1007/s12035-019-1580-8DOI Listing

Retraction Note to: Effect of N-acetyl cysteine (NAC) supplementation on positive and negative syndrome scale in schizophrenia: a systematic review and meta-analysis of randomised controlled trials.

Eur J Clin Pharmacol 2019 May;75(5):741

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

The authors have retracted this article [1] because there are fundamental errors in the data presented that undermine the conclusions drawn. All authors agree with this retraction. The authors are re-analysing their data and intend to submit a new manuscript for peer review in due course. Read More

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http://dx.doi.org/10.1007/s00228-019-02676-3DOI Listing

Ketamine-induced antidepressant like effects in mice: A possible involvement of cannabinoid system.

Biomed Pharmacother 2019 Apr 28;112:108717. Epub 2019 Feb 28.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

The purpose of this study was to explore the possible interaction between ketamine and cannabinoid system in the modulation of depression-related responses using the forced swimming test (FST), tail suspension test (TST) and open-field test (OFT) in mice. Our results revealed that intra-peritoneal (i.p. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108717DOI Listing

Addiction to DUSP1 protects JAK2V617F-driven polycythemia vera progenitors against inflammatory stress and DNA damage, allowing chronic proliferation.

Oncogene 2019 Apr 9. Epub 2019 Apr 9.

Department of Biology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.

Inflammatory and oncogenic signaling converge in disease evolution of BCR-ABL-negative myeloproliferative neoplasms, clonal hematopoietic stem cell disorders characterized by gain-of-function mutation in JAK2 kinase (JAK2V617F), with highest prevalence in patients with polycythemia vera (PV). Despite the high risk, DNA-damaging inflammatory microenvironment, PV progenitors tend to preserve their genomic stability over decades until their progression to post-PV myelofibrosis/acute myeloid leukemia. Using induced pluripotent stem cells-derived CD34 progenitor-enriched cultures from JAK2V617F PV patient and from JAK2 wild-type healthy control, CRISPR-modified HEL cells and patients' bone marrow sections from different disease stages, we demonstrate that JAK2V617F induces an intrinsic IFNγ- and NF-κB-associated inflammatory program, while suppressing inflammation-evoked DNA damage both in vitro and in vivo. Read More

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http://www.nature.com/articles/s41388-019-0813-7
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http://dx.doi.org/10.1038/s41388-019-0813-7DOI Listing
April 2019
3 Reads

Monitoring new psychoactive substances: Exploring the contribution of an online discussion forum.

Int J Drug Policy 2019 Apr 7. Epub 2019 Apr 7.

Ecole des sciences criminelles, University of Lausanne, 1015 Lausanne, Switzerland.

Background: The rapid emergence of new psychoactive substances (NPS) is a challenge for public health authorities and law enforcement. The phenomenon is strengthened since the increase of the Internet usage. Not only used to trade NPS, the Web is an important source of information for both potential drug consumers and experienced users. Read More

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http://dx.doi.org/10.1016/j.drugpo.2019.03.025DOI Listing

Implementation of a Novel Electronic Patient-Directed Smoking Cessation Platform for Cancer Patients: Interrupted Time Series Analysis.

J Med Internet Res 2019 Apr 9;21(4):e11735. Epub 2019 Apr 9.

Princess Margaret Cancer Centre, Toronto, ON, Canada.

Background: Continued smoking in cancer patients undergoing treatment results in significantly higher rates of treatment toxicities and persistent effects, increased risk of recurrence and second malignancy, and increased all-cause mortality. Despite this, routine tobacco use screening and the provision of smoking cessation treatment has yet to be implemented widely in the cancer setting.

Objective: The objective of this study was to implement and evaluate the adoption and impact of an innovative Smoking Cessation e-referral System (CEASE) to promote referrals to smoking cessation programs in cancer patients. Read More

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https://www.jmir.org/2019/4/e11735/
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http://dx.doi.org/10.2196/11735DOI Listing
April 2019
3 Reads

Parents and substance use. Editorial essay, special themed collection.

Int J Drug Policy 2019 Apr 5. Epub 2019 Apr 5.

NMAHP Research Unit, University of Stirling, United Kingdom.

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http://dx.doi.org/10.1016/j.drugpo.2019.02.011DOI Listing

An Ensemble Classifier with Case-Based Reasoning System for Identifying Internet Addiction.

Int J Environ Res Public Health 2019 Apr 6;16(7). Epub 2019 Apr 6.

Department of Information Management, National Yunlin University of Science & Technology, Douliu 64002, Taiwan.

Internet usage has increased dramatically in recent decades. With this growing usage trend, the negative impacts of Internet usage have also increased significantly. One recurring concern involves users with Internet addiction, whose Internet usage has become excessive and disrupted their lives. Read More

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http://dx.doi.org/10.3390/ijerph16071233DOI Listing

Differential levels of prefrontal cortex glutamate+glutamine in adults with antisocial personality disorder and bipolar disorder: A proton magnetic resonance spectroscopy study.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Apr 5. Epub 2019 Apr 5.

Research Imaging Centre, Campbell Family Mental Health Research Institute and Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Violence Prevention Neurobiological Research Unit, Forensic Psychiatry, CAMH, Toronto, ON, Canada; Faculty of Medicine Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Faculty of Arts and Science, Department of Criminology and Sociological Studies, University of Toronto, Toronto, ON, Canada; Waypoint Centre for Mental Health Care, Penetanguishene, ON, Canada. Electronic address:

As the main excitatory neurotransmitter in the central nervous system, glutamate, as measured in combination with glutamine (Glx), is implicated in several psychopathologies when levels are aberrant. One illness that shows heightened Glx levels is bipolar disorder (BD), an illness characterized by high impulsivity. In addition, although animal studies have reported elevated levels of Glx in aggressive and impulsive phenotypes, no study, to our knowledge, has reported Glx in the human cortex in relation to aggression. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2019.04.002DOI Listing
April 2019
1 Read

The epigenetic modulation of alcohol/ethanol and cannabis exposure/co-exposure during different stages.

Open Biol 2019 Jan;9(1):180115

2 Biomedical Sciences Program, Zewail City of Science and Technology , Giza , Egypt.

Studies have reported the significant economic impact of smoking cannabis and drinking alcohol In the USA. It was estimated that the costs of cannabis-related treatment, hospitalization and loss of work-related pay have amounted to $200 billion. (Andersen AM, Dogan MV, Beach SRH, Philibert RA. Read More

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http://dx.doi.org/10.1098/rsob.180115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367141PMC
January 2019
1 Read

Cultural Correlates of Internet Addiction.

Cyberpsychol Behav Soc Netw 2019 Apr;22(4):258-263

10 The Department of Social Work, Ariel University, Ariel, Israel.

Increasing problems connected with excessive Internet use can be observed all over the world. Internet addiction is defined as excessive involvement in the Internet with negative consequences. The main aim of the study was to investigate economic indicators as correlates of Internet addiction. Read More

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http://dx.doi.org/10.1089/cyber.2018.0667DOI Listing

Feasibility, acceptability, and cost-effectiveness of a brief, lay counsellor delivered psychological treatment for men with alcohol dependence in primary care: an exploratory randomised controlled trial.

Addiction 2019 Apr 7. Epub 2019 Apr 7.

Sangath, Socorro, Goa, India.

Aims: To examine the feasibility, acceptability, and preliminary cost-effectiveness of a lay counsellor delivered psychological treatment for men with alcohol dependence in primary care.

Design: Single-blind individually randomized trial comparing Counselling for Alcohol Problems [CAP] plus Enhanced Usual Care [EUC]) versus EUC only.

Setting: Ten primary health centres in Goa, India. Read More

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http://dx.doi.org/10.1111/add.14630DOI Listing
April 2019
1 Read

Classification of cocaine-dependent participants with dynamic functional connectivity from functional magnetic resonance imaging data.

J Neurosci Res 2019 Apr 7. Epub 2019 Apr 7.

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas.

Static functional connectivity (FC) analyses based on functional magnetic resonance imaging (fMRI) data have been extensively explored for studying various psychiatric conditions in the brain, including cocaine addiction. A recently emerging, more powerful technique, dynamic functional connectivity (DFC), studies how the FC dynamics change during the course of the fMRI experiments. The aim in this paper was to develop a computational approach, using a machine learning framework, to determine if DFC features were more successful than FC features in the classification of cocaine-dependent patients and healthy controls. Read More

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http://dx.doi.org/10.1002/jnr.24421DOI Listing
April 2019
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Methadone's effects on pentylenetetrazole-induced seizure threshold in mice: NMDA/opioid receptors and nitric oxide signaling.

Ann N Y Acad Sci 2019 Apr 7. Epub 2019 Apr 7.

Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Methadone is a synthetic opioid used to treat opiate withdrawal and addiction. Studies have demonstrated the impact of methadone on seizure susceptibility. This study investigated the modulatory impacts of acute and subchronic (three times daily for 5 days) intraperitoneal methadone treatment on pentylenetetrazole-induced clonic seizure threshold (CST) in mice, as well as the involvement of the nitric oxide, N-methyl-d-aspartate (NMDA), and μ-opioid pathways. Read More

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http://dx.doi.org/10.1111/nyas.14043DOI Listing
April 2019
4.313 Impact Factor

Associations between e-cigarette and combustible cigarette use among U.S. cancer survivors: implications for research and practice.

J Cancer Surviv 2019 Apr 6. Epub 2019 Apr 6.

Department of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, IN, 47405, USA.

Purpose: Prior studies established significant associations between e-cigarette use and combustible cigarette smoking in the general population; however, little is known about such associations among cancer survivors. Thus, the current study examined possible associations between e-cigarette use and combustible cigarette smoking among U.S. Read More

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http://dx.doi.org/10.1007/s11764-019-00753-1DOI Listing

Neuro-hormonal mechanisms underlying changes in reward related behaviors following weight loss surgery: Potential pharmacological targets.

Biochem Pharmacol 2019 Apr 4;164:106-114. Epub 2019 Apr 4.

Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, United States.

Currently, the only available effective treatment option for obesity and its comorbidities is weight loss surgery (WLS). Long-term maintenance of weight loss after surgery cannot be explained by caloric restriction or malabsorption alone and has been attributed to unexplained changes in eating behavior. Whether these behavioral changes are related to altered taste or reward functions, or both, are subject to debate. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.04.004DOI Listing
April 2019
1 Read

How to determine whether conceptual endophenotypes can improve clinical outcomes in patients suffering from major depression: An exploratory approach.

Psychoneuroendocrinology 2019 Mar 15. Epub 2019 Mar 15.

Department of Psychology, Division of Clinical and Physiological Psychology, Trier University, Johanniterufer 15, D-54290 Trier, Germany.

Depression is a complex mental health disorder, resulting in a high degree of disability. Since symptom constellation, course, and outcome are heterogeneous in these patients, current research initiatives are striving to establish stratified diagnostic and treatment approaches. In the past two decades, Dirk Hellhammer and his team introduced Neuropattern, a new diagnostic concept, which is based on conceptual endophenotypes of the stress response network. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.03.010DOI Listing
March 2019
1 Read

Melatonin Pretreatment Attenuates Acute Methamphetamine-induced Aggression in Male ICR Mice.

Brain Res 2019 Apr 3. Epub 2019 Apr 3.

Department of Epidemiology & Health Statistics, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, 13 Hangkong Road, Wuhan 430030, China. Electronic address:

Aggression is one of the symptoms of methamphetamine (MA) use and withdrawal, which can exacerbate MA addiction and relapse. Many studies have demonstrated that poor sleep is significantly associated with aggression. Melatonin has been indicated to be effective in treating sleep disorders induced by MA, and it can also protect neuronal cells against MA-induced neurotoxicity. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.002DOI Listing
April 2019
2 Reads

HIV pre-exposure prophylaxis uptake by advanced practice nurses: interplay of agency, community, and attitudinal factors.

J Adv Nurs 2019 Apr 5. Epub 2019 Apr 5.

School of Nursing, Indiana University - Purdue University Indianapolis (IUPUI), United States.

Aims: To identify associations among agency, community, personal and attitudinal factors that affect advanced practice nurses' uptake of HIV pre-exposure prophylaxis, an intervention consists of emtricitabine/tenofovir once-daily pill, along with sexual risk reduction education.

Design: Cross-sectional.

Methods: During March-May 2017, randomly-selected Indiana advanced practice nurses were invited to complete an online survey, consisted of several validated self-rating measures (N=1,358; response=32. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jan.14019
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http://dx.doi.org/10.1111/jan.14019DOI Listing
April 2019
4 Reads

Inhibitory effects of Shati/Nat8l overexpression in the medial prefrontal cortex on methamphetamine-induced conditioned place preference in mice.

Addict Biol 2019 Apr 5. Epub 2019 Apr 5.

Department of Pharmaceutical Therapy and Neuropharmacology, Faculty of Pharmaceutical Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.

Shati/Nat8l is a novel N-acetyltransferase identified in the brain of mice treated with methamphetamine (METH). Shati/Nat8l mRNA is expressed in various brain areas, including the prefrontal cortex (PFC), where the expression level is higher than that in other brain regions. Shati/Nat8l overexpression in the nucleus accumbens (NAc) attenuates the pharmacological response to METH via mGluR3. Read More

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http://dx.doi.org/10.1111/adb.12749DOI Listing
April 2019
1 Read

DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats.

Addict Biol 2019 Apr 5. Epub 2019 Apr 5.

CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.

Drug-reinforced excessive operant responding is one fundamental feature of long-lasting addiction-like behaviors and relapse in animals. However, the transcriptional regulatory mechanisms responsible for the persistent drug-specific (not natural rewards) operant behavior are not entirely clear. In this study, we demonstrate a key role for one of the de novo DNA methyltransferase, DNMT3a, in the acquisition of morphine self-administration (SA) in rats. Read More

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http://dx.doi.org/10.1111/adb.12730DOI Listing

The Relationship Between Parental Attachment and Mobile Phone Dependence Among Chinese Rural Adolescents: The Role of Alexithymia and Mindfulness.

Front Psychol 2019 20;10:598. Epub 2019 Mar 20.

College of Psychology and Sociology, Shenzhen University, Shenzhen, China.

Mobile phone has experienced a significant increase in popularity among adolescents in recent years. Findings indicate dependence on mobile phone is related to poor parent-child relationship. However, previous research on mobile phone dependence (MPD) is scant and mainly focus on adult samples. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435572PMC
March 2019
1 Read

Prolonged exposure of rats to varenicline increases anxiety and alters serotonergic system, but has no effect on memory.

Pharmacol Biochem Behav 2019 Apr 1;181:1-8. Epub 2019 Apr 1.

Graduate Program of Experimental and Comparative Pathology, Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87, 05508-270 São Paulo, Brazil. Electronic address:

Varenicline is a drug used for smoking addiction cessation treatment and acts as a partial agonist of nicotinic cholinergic receptors. Recent clinical trial data support use of varenicline for treatment of conditions/addictions that are not related to smoking cessation. Considering the importance of this issue and the need for new studies on its effects, especially on behavior, more studies using animal models are necessary. Read More

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http://dx.doi.org/10.1016/j.pbb.2019.03.009DOI Listing

Interoceptive awareness is associated with acute alcohol-induced changes in subjective effects.

Pharmacol Biochem Behav 2019 Apr 1. Epub 2019 Apr 1.

University of Sussex, Behavioural and Clinical Neuroscience, School of Psychology, Brighton BN1 9QH, UK; Sussex Addiction Research and Intervention Centre (SARIC), University of Sussex, UK. Electronic address:

Interoception, the sensing of bodily signals, is related to emotional reactivity and may contribute to the pathophysiology of addiction. Evidence is accumulating that individuals with alcohol use disorders and other substance-dependences show altered interoceptive processing, however little is known about the acute effects of alcohol on interoception and how this may influence the perception of drug induced effects. In a double-blind design, fifty (30 females) healthy young participants were given a beverage containing either a low (0. Read More

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http://dx.doi.org/10.1016/j.pbb.2019.03.007DOI Listing
April 2019
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Reversal of Peripheral Neuropathic Pain by the Small-Molecule Natural Product Physalin F via Block of CaV2.3 (R-Type) and CaV2.2 (N-Type) Voltage-Gated Calcium Channels.

ACS Chem Neurosci 2019 Apr 18. Epub 2019 Apr 18.

The Center for Innovation in Brain Sciences , The University of Arizona Health Sciences , Tucson , Arizona 85724 , United States.

No universally efficacious therapy exists for chronic pain, a disease affecting one-fifth of the global population. An overreliance on the prescription of opioids for chronic pain despite their poor ability to improve function has led to a national opioid crisis. In 2018, the NIH launched a Helping to End Addiction Long-term plan to spur discovery and validation of novel targets and mechanisms to develop alternative nonaddictive treatment options. Read More

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http://dx.doi.org/10.1021/acschemneuro.9b00166DOI Listing
April 2019
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Differences in the rate of nicotine metabolism among smokers with and without HIV.

AIDS 2019 May;33(6):1083-1088

Department of Psychiatry, University of Pennsylvania Perelman School of Medicine.

Objective: HIV-infected smokers lose more life years to tobacco use than to HIV infection. The nicotine metabolite ratio (NMR), a biomarker of CYP2A6, represents individual variation in the rate at which nicotine is metabolized and is associated with response to smoking cessation treatments. We evaluated whether HIV-infected smokers metabolize nicotine faster than HIV-uninfected smokers, which may contribute to the disproportionate smoking burden and may have important treatment implications. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457129PMC
May 2019
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Brain Imaging of Taste Perception in Obesity: a Review.

Curr Nutr Rep 2019 Apr 4. Epub 2019 Apr 4.

Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Dr, Rm B2L124, Bethesda, MD, 20892-1013, USA.

Purpose Of Review: We summarize neuroimaging findings related to processing of taste (fat, salt, umami, bitter, and sour) in the brain and how they influence hedonic responses and eating behaviors and their role in obesity.

Recent Findings: Neuroimaging studies in obese individuals have revealed alterations in reward/motivation, executive control/self-regulation, and limbic/affective circuits that are implicated in food and drug addiction. Psychophysical studies show that sensory properties of food ingredients may be associated with anthropometric and neurocognitive outcomes in obesity. Read More

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http://dx.doi.org/10.1007/s13668-019-0269-yDOI Listing
April 2019
5 Reads

Excessive Consumption of Sugar: an Insatiable Drive for Reward.

Curr Nutr Rep 2019 Apr 3. Epub 2019 Apr 3.

Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, USA.

Purpose Of Review: Eating behavior provides energy to ensure proper functioning of the organism. Reward aids in seeking foods that bring energy and pleasant taste, whose consumption is safe. As evidenced by the obesity "epidemic" which largely stems from overeating, reward becomes a detriment when palatable tastants are available in unlimited quantities. Read More

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http://link.springer.com/10.1007/s13668-019-0270-5
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http://dx.doi.org/10.1007/s13668-019-0270-5DOI Listing
April 2019
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The emergence of Exercise Addiction, Body Dysmorphic Disorder, and other image-related psychopathological correlates in fitness settings: A cross sectional study.

PLoS One 2019 3;14(4):e0213060. Epub 2019 Apr 3.

Centre for Clinical & Health Research Services, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.

Introduction: In a society that perpetuates the strive for a perfect appearance, a fit body has become synonymous with success, but simultaneously hard to achieve. This represents a fertile ground for the development of Exercise Addiction (EA) alongside other disorders, such as Body Dysmorphic Disorder (BDD). This study aims to explore the diffusion of EA in fitness settings in the United Kingdom, Italy, Netherlands, Hungary and the previously unexplored association with appearance anxiety, BDD, self-esteem and the use of fitness supplements. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213060PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447162PMC
April 2019
3 Reads

Anabolic androgenic steroid dependence is associated with impaired emotion recognition.

Psychopharmacology (Berl) 2019 Apr 2. Epub 2019 Apr 2.

The Anabolic Androgenic Steroid Research Group, National Advisory Unit on Substance Use Disorder Treatment, the Division of Mental Health and Addiction, Oslo University Hospital, Postbox 4959, Nydalen, 0424, Oslo, Norway.

Rationale: Illicit use of anabolic androgenic steroids (AAS) has grown into a serious public health concern throughout the Western World. AAS use is associated with adverse medical, psychological, and social consequences. Around 30% of AAS users develop a dependence syndrome with sustained use despite adverse side effects. Read More

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http://dx.doi.org/10.1007/s00213-019-05239-7DOI Listing
April 2019
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What proportion of striatal D2 receptors are occupied by endogenous dopamine at baseline? A meta-analysis with implications for understanding antipsychotic occupancy.

Neuropharmacology 2019 Mar 30. Epub 2019 Mar 30.

Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada; Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, M5T 1R8, Canada; Institute of Medical Science, University of Toronto, 1 Kings College Circle, Toronto, Ontario, M5S 1A8, Canada.

Using molecular imaging techniques - positron emission tomography (PET) and single-photon emission computed tomography (SPECT) - in conjunction with an acute dopamine depletion challenge (alpha-methyl-para-tyrosine) it is possible to estimate endogenous dopamine levels occupying striatal dopamine D receptors (DR) in humans in vivo. However, it is unclear what proportion of striatal DR are occupied by endogenous dopamine under normal conditions. This is important since it has been suggested that in schizophrenia there may be a substantial proportion of striatal DR which are occupied by endogenous dopamine and not accessible by therapeutic doses of antipsychotics. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.03.034DOI Listing
March 2019
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Indeed, not really a brain disorder: Implications for reductionist accounts of addiction.

Behav Brain Sci 2019 01;42:e9

Department of Psychology,University of Amsterdam,PB 15916,1001 NK Amsterdam,The

Borsboom et al.'s formulation provides an opportunity for a fundamental rethink about the "brain disease model" of addiction that dominates research, treatment, policy, and lay understanding of addiction. We also demonstrate how the American opioid crisis provides a contemporary example of how "brain disease" is not moderated by the environmental context but is instead crucially dependent upon it. Read More

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http://dx.doi.org/10.1017/S0140525X18001024DOI Listing
January 2019
3 Reads