1,783 results match your criteria Addiction Biology[Journal]


Effects of 5-HT receptor stimulation on economic demand for fentanyl after intermittent and continuous access self-administration in male rats.

Addict Biol 2020 May 26:e12926. Epub 2020 May 26.

Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

The relative value of and motivation for abused drugs often increases with drug experience and differs based on drug availability. Here, we determined how different intake patterns of fentanyl, a μ-opioid agonist, alter economic demand for fentanyl and how 5-HT receptor stimulation affects economic demand for fentanyl. We used a within-session demand threshold procedure to characterize changes in economic demand for fentanyl before and after intermittent or continuous access schedules. Read More

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http://dx.doi.org/10.1111/adb.12926DOI Listing

Increased striatal functional connectivity is associated with improved smoking cessation outcomes: A preliminary study.

Addict Biol 2020 May 21:e12919. Epub 2020 May 21.

Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

The striatum is the critical area of reward processing and has been repeatedly linked to nicotine addiction. However, it remains unclear whether different smoking cessation outcomes (relapse or not) are associated with different functional connectivity changes of the striatum during smoking cessation treatment. A total of 30 treatment-seeking smokers were recruited in the study and underwent magnetic resonance imaging (MRI) scans immediately before and after a 12-week treatment with varenicline. Read More

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http://dx.doi.org/10.1111/adb.12919DOI Listing

Adolescent alcohol use disrupts functional neurodevelopment in sensation seeking girls.

Addict Biol 2020 May 19:e12914. Epub 2020 May 19.

Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.

Exogenous causes, such as alcohol use, and endogenous factors, such as temperament and sex, can modulate developmental trajectories of adolescent neurofunctional maturation. We examined how these factors affect sexual dimorphism in brain functional networks in youth drinking below diagnostic threshold for alcohol use disorder (AUD). Based on the 3-year, annually acquired, longitudinal resting-state functional magnetic resonance imaging (MRI) data of 526 adolescents (12-21 years at baseline) from the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) cohort, developmental trajectories of 23 intrinsic functional networks (IFNs) were analyzed for (1) sexual dimorphism in 259 participants who were no-to-low drinkers throughout this period; (2) sex-alcohol interactions in two age- and sex-matched NCANDA subgroups (N = 76 each), half no-to-low, and half moderate-to-heavy drinkers; and (3) moderating effects of gender-specific alcohol dose effects and a multifactorial impulsivity measure on IFN connectivity in all NCANDA participants. Read More

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http://dx.doi.org/10.1111/adb.12914DOI Listing

The effects of morphine withdrawal and conditioned withdrawal on memory consolidation and c-Fos expression in the central amygdala.

Addict Biol 2020 May 17:e12909. Epub 2020 May 17.

Department of Psychology & Neuroscience, University of Guelph, Guelph, Canada.

The current study tested the hypothesis that drug withdrawal contributes to the addiction cycle in part because of an action on memory consolidation. Hence, four experiments in male Sprague-Dawley rats compared the effects of precipitated morphine withdrawal and conditioned morphine withdrawal on the consolidation of object memory and on activation of c-Fos in the central nucleus of the amygdala (CeA). It was found that immediate, but not 6 h delayed, post sample administration of 3 mg/kg of naltrexone significantly enhanced object memory in rats maintained, or previously maintained, on 10 mg/kg/day of morphine via osmotic minipumps. Read More

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http://dx.doi.org/10.1111/adb.12909DOI Listing

Altered intrinsic connectivity distribution in internet gaming disorder and its associations with psychotherapy treatment outcomes.

Addict Biol 2020 May 16:e12917. Epub 2020 May 16.

Institute of Developmental Psychology, Faculty of Psychology, Beijing Normal University, Beijing, China.

Alterations in brain connectivity have been implicated in internet gaming disorder (IGD). However, little is known about alterations in whole-brain connectivity and their associations with long-term treatment outcomes. Here, we used a relatively new analytic approach, intrinsic connectivity distribution (ICD) analysis, to examine brain connectivity in 74 IGD participants and 41 matched healthy controls (HCs) and conducted post hoc seed-based resting-state functional connectivity (rsFC) analyses based on the ICD findings. Read More

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http://dx.doi.org/10.1111/adb.12917DOI Listing

Effects of a selective long-acting amylin receptor agonist on alcohol consumption, food intake and body weight in male and female rats.

Addict Biol 2020 May 8:e12910. Epub 2020 May 8.

Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Alcohol use disorder is a complex neuropsychiatric disorder affecting both males and females worldwide; however, the efficacy of current pharmacotherapies varies. Recent advances show that gut-brain peptides, like amylin, regulate alcohol behavioural responses by acting on brain areas involved in alcohol reward processes. Thus, the activation of amylin receptors (AMYRs) by salmon calcitonin (sCT) decreases alcohol behaviours in male rodents. Read More

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http://dx.doi.org/10.1111/adb.12910DOI Listing

Naphyrone (naphthylpyrovalerone): Pharmacokinetics, behavioural effects and thermoregulation in Wistar rats.

Addict Biol 2020 May 7:e12906. Epub 2020 May 7.

Department of Experimental Neurobiology, National Institute of Mental Health, Klecany, Czech Republic.

Naphthylpyrovalerone (naphyrone) is a pyrovalerone cathinone that potently inhibits monoamine transporters and provides stimulatory-entactogenic effects. Little is known about the safety of naphyrone or its effects in vivo, and more research is needed to acquire knowledge about its fundamental effects on physiology and behaviour. Our objective was to investigate naphyrone's pharmacokinetics, acute toxicity, hyperthermic potential and stimulatory and psychotomimetic properties in vivo in male Wistar rats. Read More

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http://dx.doi.org/10.1111/adb.12906DOI Listing

A neural mechanism of the relationship between impulsivity and emotion dysregulation in patients with Internet gaming disorder.

Addict Biol 2020 May 4:e12916. Epub 2020 May 4.

Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Impulsivity and emotion dysregulation have been known to be risk factors for Internet gaming disorder (IGD), but their underlying neural mechanisms are not yet fully understood. Given that the prefrontal cortex has a key role in higher order cognition and addiction, the present study aimed to investigate emotional influences on response inhibition in situations with different cognitive demands. A total of 41 young male adults (20 with and 21 without IGD) were scanned while performing two versions of an emotional go/no-go task with demands on low and high working memory load. Read More

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http://dx.doi.org/10.1111/adb.12916DOI Listing

Repeated nicotine exposure increases the intracellular interaction between ERK-mGluR5 in the nucleus accumbens more in adult than adolescent rats.

Addict Biol 2020 Apr 27:e12913. Epub 2020 Apr 27.

Department of Biological Sciences, Pusan National University, Busan, South Korea.

Intracellular interactions between protein kinases and metabotropic receptors in the striatum regulate behavioral changes in response to drug exposure. We investigated the difference in the degree of interaction between extracellular signal-regulated kinase (ERK) and metabotropic glutamate receptor subtype 5 (mGluR5) in the nucleus accumbens (NAc) after repeated exposure to nicotine in adult and adolescent rats. The results showed that repeated exposure to nicotine (0. Read More

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http://dx.doi.org/10.1111/adb.12913DOI Listing

Enhancement of alcohol aversion by the nicotinic acetylcholine receptor drug sazetidine-A.

Addict Biol 2020 Apr 24:e12908. Epub 2020 Apr 24.

Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.

The prevalence of alcohol use disorders (AUDs) has steadily increased in the United States over the last 30 years. Alcohol acts on multiple receptor systems including the nicotinic acetylcholine receptors (nAChRs), which are known to mediate alcohol consumption and reward. We previously reported that the preclinical drug sazetidine-A, a nAChR agonist and desensitizer, reduces alcohol consumption without affecting nicotine consumption in C57BL/6J mice. Read More

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http://dx.doi.org/10.1111/adb.12908DOI Listing

Maternal separation increases cocaine intake through a mechanism involving plasticity in glutamate signalling.

Addict Biol 2020 Apr 24:e12911. Epub 2020 Apr 24.

Neurobiology of Behaviour Research Group (GReNeC-NeuroBio), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.

Early-life stress (ELS) is associated with negative consequences, including maladaptive long-lasting brain effects. These alterations seem to increase the likelihood of developing substance use disorders. However, the molecular consequences of ELS are poorly understood. Read More

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http://dx.doi.org/10.1111/adb.12911DOI Listing

Impaired motor cortical plasticity associated with cannabis use disorder in young adults.

Addict Biol 2020 Apr 23:e12912. Epub 2020 Apr 23.

Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.

Maladaptive cortical plasticity has been described in individuals with heroin and methamphetamine addiction and may mediate other substance abuse disorders. It is unknown whether cannabis dependence in humans alters the capacity for induction of cortical plasticity. The aim of this study was to non-invasively investigate cortical plasticity with transcranial magnetic stimulation in young adults who meet DSM-5 criteria for cannabis use disorder (CUD). Read More

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http://dx.doi.org/10.1111/adb.12912DOI Listing

Sugar intake and craving during alcohol withdrawal in alcohol use disorder inpatients.

Addict Biol 2020 Apr 19:e12907. Epub 2020 Apr 19.

Addictions Department, CHU Caremeau, Nîmes, France.

To assess whether changes in sugar intake and craving occur during alcohol withdrawal in humans, we conducted a prospective, observational study in a university hospital addictions treatment center. Recruited patients had severe alcohol use disorder and were hospitalized for 7 days in the short-stay unit for alcohol withdrawal and then for 6 weeks in the rehabilitation unit. During the hospital stay, they had no access to alcohol but had full access to sweet products and beverages in a shop and vending machines located inside the hospital. Read More

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http://dx.doi.org/10.1111/adb.12907DOI Listing

Nicotine abolishes memory-related synaptic strengthening and promotes synaptic depression in the neurogenic dentate gyrus of miR-132/212 knockout mice.

Addict Biol 2020 Apr 15:e12905. Epub 2020 Apr 15.

Center for Physiology and Pharmacology, Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, Vienna, Austria.

Micro-RNAs (miRNAs) are highly evolutionarily conserved short-length/noncoding RNA molecules that modulate a wide range of cellular functions in many cell types by regulating the expression of a variety of targeted genes. miRNAs have also recently emerged as key regulators of neuronal genes mediating the effects of psychostimulant drugs and memory-related neuroplasticity processes. Smoking is a predominant addictive behaviour associated with millions of deaths worldwide, and nicotine is a potent natural psychoactive agonist of cholinergic receptors, highly abundant in cigarettes. Read More

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http://dx.doi.org/10.1111/adb.12905DOI Listing

Biomarkers of endothelial dysfunction in cocaine overdose and overdose-related cardiovascular events.

Addict Biol 2020 Apr 15:e12901. Epub 2020 Apr 15.

Departments of Psychiatry, Neuroscience, and Pharmacological Sciences, The Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Overdose of stimulant drugs has been associated with increased risk of adverse cardiovascular events (ACVE), some of which may be ascribed to endothelial dysfunction. The aims of this study were to evaluate biomarkers of endothelial dysfunction in emergency department (ED) patients with acute cocaine overdose and to assess the association between in-hospital ACVE in ED patients with any acute drug overdose. This was a prospective consecutive cohort study over 9 months (2015-2016) at two urban, tertiary-care hospital EDs. Read More

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http://dx.doi.org/10.1111/adb.12901DOI Listing

The future of translational research on alcohol use disorder.

Addict Biol 2020 Apr 14:e12903. Epub 2020 Apr 14.

National Institute on Drug Abuse, Baltimore, Maryland, USA.

In March 2019, a scientific meeting was held at the University of California, Los Angeles (UCLA) Luskin Center to discuss approaches to expedite the translation of neurobiological insights to advances in the treatment of alcohol use disorder (AUD). A guiding theme that emerged was that while translational research in AUD is clearly a challenge, it is also a field ripe with opportunities. Herein, we seek to summarize and disseminate the recommendations for the future of translational AUD research using four sections. Read More

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http://dx.doi.org/10.1111/adb.12903DOI Listing

Gene-based association analysis reveals involvement of LAMA5 and cell adhesion pathways in nicotine dependence in African- and European-American samples.

Addict Biol 2020 Apr 13:e12898. Epub 2020 Apr 13.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Nicotine dependence (ND) is a chronic brain disorder that causes heavy social and economic burdens. Although many susceptibility genetic loci have been reported, they can explain only approximately 5%-10% of the genetic variance for the disease. To further explore the genetic etiology of ND, we genotyped 242 764 SNPs using an exome chip from both European-American (N = 1572) and African-American (N = 3371) samples. Read More

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http://dx.doi.org/10.1111/adb.12898DOI Listing

A meta-analysis of tract-based spatial statistics studies examining white matter integrity in cocaine use disorder.

Addict Biol 2020 Apr 8:e12902. Epub 2020 Apr 8.

Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.

Tract-based spatial statistics (TBSS) of diffusion tensor imaging (DTI) studies have consistently shown diminished white matter (WM) integrity for individuals with cocaine use disorder (CUD). The present study used seed-based d mapping (SDM) to determine the extent to which a systematic difference in the WM integrity of cocaine users may exist (as compared with that of healthy controls). Articles from 2006 (when TBSS was first developed) to present were reviewed, with eight selected for inclusion. Read More

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http://dx.doi.org/10.1111/adb.12902DOI Listing

Ethanol produces multiple electrophysiological effects on ventral tegmental area neurons in freely moving rats.

Addict Biol 2020 Apr 7:e12899. Epub 2020 Apr 7.

Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Although alcohol (i.e., ethanol) is a major drug of abuse, the acute functional effects of ethanol on the reward circuitry are not well defined in vivo. Read More

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http://dx.doi.org/10.1111/adb.12899DOI Listing

Interactions between reinforcement history and drug-primed reinstatement: Studies with MDPV and mixtures of MDPV and caffeine.

Addict Biol 2020 Apr 1:e12904. Epub 2020 Apr 1.

Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.

Many drugs of abuse are mixed with other psychoactive substances (e.g., caffeine) prior to their sale or use. Read More

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http://dx.doi.org/10.1111/adb.12904DOI Listing

N-acetylcysteine reduces cocaine-seeking behavior and anterior cingulate glutamate/glutamine levels among cocaine-dependent individuals.

Addict Biol 2020 Mar 24:e12900. Epub 2020 Mar 24.

Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA.

N-acetylcysteine (NAC) is a cystine prodrug shown to reduce cocaine- and cue-primed reinstatement of cocaine-seeking behavior in preclinical studies. In this inpatient study, the effects of NAC maintenance versus placebo on cocaine-seeking behavior were examined during cocaine-primed and unprimed self-administration sessions among non-treatment-seeking, cocaine-dependent individuals. Twelve participants completed this double-blind, placebo-controlled, within-subject crossover study. Read More

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http://dx.doi.org/10.1111/adb.12900DOI Listing

Enduring consequences of perinatal fentanyl exposure in mice.

Addict Biol 2020 Mar 18:e12895. Epub 2020 Mar 18.

Department of Anatomy & Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA.

Opioid use by pregnant women is an understudied consequence associated with the opioid epidemic, resulting in a rise in the incidence of neonatal opioid withdrawal syndrome (NOWS) and lifelong neurobehavioral deficits that result from perinatal opioid exposure. There are few preclinical models that accurately recapitulate human perinatal drug exposure and few focus on fentanyl, a potent synthetic opioid that is a leading driver of the opioid epidemic. To investigate the consequences of perinatal opioid exposure, we administered fentanyl to mouse dams in their drinking water throughout gestation and until litters were weaned at postnatal day (PD) 21. Read More

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http://dx.doi.org/10.1111/adb.12895DOI Listing

The role of the serotonin transporter in prefrontal cortex glutamatergic signaling following short- and long-access cocaine self-administration.

Addict Biol 2020 Mar 18:e12896. Epub 2020 Mar 18.

Department of Cognitive Neuroscience, Division of Molecular Neurogenetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

Vulnerability to drug addiction relies on substantial individual differences. We previously demonstrated that serotonin transporter knockout (SERT ) rats show increased cocaine intake and develop signs of compulsivity. However, the underlying neural mechanisms are not fully understood. Read More

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http://dx.doi.org/10.1111/adb.12896DOI Listing

Microglia depletion and alcohol: Transcriptome and behavioral profiles.

Addict Biol 2020 Mar 16:e12889. Epub 2020 Mar 16.

Waggoner Center for Alcoholism and Addiction Research, University of Texas at Austin, Austin, TX, USA.

Alcohol abuse induces changes in microglia morphology and immune function, but whether microglia initiate or simply amplify the harmful effects of alcohol exposure is still a matter of debate. Here, we determine microglia function in acute and voluntary drinking behaviors using a colony-stimulating factor 1 receptor inhibitor (PLX5622). We show that microglia depletion does not alter the sedative or hypnotic effects of acute intoxication. Read More

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http://dx.doi.org/10.1111/adb.12889DOI Listing

The role of HINT1 protein in morphine addiction: An animal model-based study.

Addict Biol 2020 Mar 14:e12897. Epub 2020 Mar 14.

College of Medicine and Forensics, Key Laboratory of the Health Ministry for Forensic Medicine, Key Laboratory of Environment and Genes Related to Diseases of the Education Ministry, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.

Drug addiction is a recurrent, chronic brain disease. The existing treatment methods have limitations, such as poor adherence and inability to completely avoid relapse. Histidine triad nucleotide-binding protein 1 (HINT1) is involved in many neuropsychiatric diseases, such as schizophrenia, pain, and drug dependence. Read More

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http://dx.doi.org/10.1111/adb.12897DOI Listing

Assessing effects of oxytocin on alcohol consumption in socially housed prairie voles using radio frequency tracking.

Addict Biol 2020 Mar 11:e12893. Epub 2020 Mar 11.

Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, 97239, USA.

Alcohol use disorder affects millions of people each year. Currently approved pharmacotherapies have limited success in treating this disorder. Evidence suggests that this lack of success is partly due to how these pharmacotherapies are tested in preclinical settings. Read More

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http://dx.doi.org/10.1111/adb.12893DOI Listing

The role of the insula in internet gaming disorder.

Addict Biol 2020 Mar 8:e12894. Epub 2020 Mar 8.

Brain and Creativity Institute, University of Southern California, Los Angeles, California, USA.

Internet gaming disorder (IGD) is a concerning issue that requires further research. Here, we seek to examine its neural etiology with an emphasis on the role of the insula. To do so, we relied on the tripartite neurocognitive model of addictive behaviors as applied to IGD. Read More

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http://dx.doi.org/10.1111/adb.12894DOI Listing

Is R(+)-Baclofen the best option for the future of Baclofen in alcohol dependence pharmacotherapy? Insights from the preclinical side.

Addict Biol 2020 Mar 8:e12892. Epub 2020 Mar 8.

INSERM UMR 1247-Research Group on Alcohol and Pharmacodependences (GRAP), Université de Picardie Jules Verne, Amiens, France.

For several decades, studies conducted to evaluate the efficacy of RS(±)-Baclofen in the treatment of alcohol dependence yielded contrasting results. Human and animal studies recently questioned the use of the racemic drug in patients since a potential important role of the different enantiomers has been revealed with an efficacy thought to reside with the active R(+)-enantiomer. Here we conducted experiments in the postdependent rat model of alcohol dependence to compare the efficacy of R(+)-Baclofen or S(-)-Baclofen to that of RS(±)-Baclofen on ethanol intake, seeking, and relapse. Read More

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http://dx.doi.org/10.1111/adb.12892DOI Listing

Adolescent nicotine induces depressive and anxiogenic effects through ERK 1-2 and Akt-GSK-3 pathways and neuronal dysregulation in the nucleus accumbens.

Addict Biol 2020 Mar 5:e12891. Epub 2020 Mar 5.

Addiction Research Group, University of Western Ontario, London, Ontario, Canada.

Long-term tobacco dependence typically develops during adolescence and neurodevelopmental nicotine exposure is associated with affective disturbances that manifest as a variety of neuropsychiatric comorbidities in clinical and preclinical studies, including mood and anxiety-related disorders. The nucleus accumbens shell (NASh) is critically involved in regulating emotional processing, and both molecular and neuronal disturbances in this structure are associated with mood and anxiety-related pathologies. In the present study, we used a rodent model of adolescent neurodevelopmental nicotine exposure to examine the expression of several molecular biomarkers associated with mood/anxiety-related phenotypes. Read More

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http://dx.doi.org/10.1111/adb.12891DOI Listing

Alcohol use disorder and cannabis use disorder symptomatology in adolescents is associated with dysfunction in neural processing of future events.

Addict Biol 2020 Mar 5:e12885. Epub 2020 Mar 5.

Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, Nebraska.

Two of the most commonly used substances by adolescents in the United States are cannabis and alcohol. Cannabis use disorder (CUD) and alcohol use disorder (AUD) are associated with impairments in decision-making processes. One mechanism for impaired decision-making in these individuals is thought to be an inability to adequately represent future events during decision-making. Read More

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http://dx.doi.org/10.1111/adb.12885DOI Listing

Differential correlation of serum BDNF and microRNA content in rats with rapid or late onset of heavy alcohol use.

Addict Biol 2020 Mar 5:e12890. Epub 2020 Mar 5.

Department of Neurology, University of California, San Francisco, San Francisco, California.

Heavy alcohol use reduces the levels of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex of rodents through the upregulation of microRNAs (miRs) targeting BDNF mRNA. In humans, an inverse correlation exists between circulating blood levels of BDNF and the severity of psychiatric disorders including alcohol abuse. Here, we set out to determine whether a history of heavy alcohol use produces comparable alterations in the blood of rats. Read More

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http://dx.doi.org/10.1111/adb.12890DOI Listing

Hyperfunction of the stress response system and novelty-induced hyperactivity correlate with enhanced cocaine-induced conditioned place preference in NCAM-deficient mice.

Addict Biol 2020 Mar 2:e12887. Epub 2020 Mar 2.

Institute for Biosynthesis of Neural Structures, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Several studies in humans and rodents suggest an association between impulsivity and activity of the stress response on the one hand and addiction vulnerability on the other. The neural cell adhesion molecule (NCAM) has been related to several neuropsychiatric disorders in humans. Constitutively NCAM-deficient (-/-) mice display enhanced novelty-induced behavior and hyperfunction of the hypothalamic-pituitary-adrenal axis. Read More

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http://dx.doi.org/10.1111/adb.12887DOI Listing

Significant, replicable, and functional associations between KTN1 variants and alcohol and drug codependence.

Addict Biol 2020 Mar 1:e12888. Epub 2020 Mar 1.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

The gray matter volume (GMV) of the putamen has been reported to be regulated by kinectin 1 gene (KTN1). As a hub of the dopaminergic circuit, the putamen is widely implicated in the etiological processes of substance use disorders (SUD). Here, we aimed to identify robust and reliable associations between KTN1 SNPs and SUD across multiple samples. Read More

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http://dx.doi.org/10.1111/adb.12888DOI Listing

Remote memory of drug experiences coexists with cognitive decline and abnormal adult neurogenesis in an animal model of cocaine-altered cognition.

Addict Biol 2020 Feb 23:e12886. Epub 2020 Feb 23.

Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain.

Cocaine addiction is a chronic disorder in which the person loses control over drug use. The past memories of the stimuli associated with the drug are a relevant clinical problem, since they trigger compulsive drug-seeking and drug-taking habits. Furthermore, these persistent drug-related memories seemingly coexist with cognitive decline that predicts worse therapeutic output. Read More

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http://dx.doi.org/10.1111/adb.12886DOI Listing
February 2020

Drinking and responses to antidrinking messages among young adults: An fMRI study.

Addict Biol 2020 Feb 18:e12882. Epub 2020 Feb 18.

Department of Psychiatry, Yale School of Medicine, New Haven, CT.

Young adults consume most of their alcohol by binge drinking, and more than one-third report binge drinking in the past month. Some will transition out of excessive drinking, while others will maintain or increase alcohol use into adulthood. Public health campaigns depicting negative consequences of drinking have shown some efficacy at reducing this behavior. Read More

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http://dx.doi.org/10.1111/adb.12882DOI Listing
February 2020

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.

Authors:
Melissa A Munn-Chernoff Emma C Johnson Yi-Ling Chou Jonathan R I Coleman Laura M Thornton Raymond K Walters Zeynep Yilmaz Jessica H Baker Christopher Hübel Scott Gordon Sarah E Medland Hunna J Watson Héléna A Gaspar Julien Bryois Anke Hinney Virpi M Leppä Manuel Mattheisen Stephan Ripke Shuyang Yao Paola Giusti-Rodríguez Ken B Hanscombe Roger A H Adan Lars Alfredsson Tetsuya Ando Ole A Andreassen Wade H Berrettini Ilka Boehm Claudette Boni Vesna Boraska Perica Katharina Buehren Roland Burghardt Matteo Cassina Sven Cichon Maurizio Clementi Roger D Cone Philippe Courtet Scott Crow James J Crowley Unna N Danner Oliver S P Davis Martina de Zwaan George Dedoussis Daniela Degortes Janiece E DeSocio Danielle M Dick Dimitris Dikeos Christian Dina Monika Dmitrzak-Weglarz Elisa Docampo Laramie E Duncan Karin Egberts Stefan Ehrlich Geòrgia Escaramís Tõnu Esko Xavier Estivill Anne Farmer Angela Favaro Fernando Fernández-Aranda Manfred M Fichter Krista Fischer Manuel Föcker Lenka Foretova Andreas J Forstner Monica Forzan Christopher S Franklin Steven Gallinger Ina Giegling Johanna Giuranna Fragiskos Gonidakis Philip Gorwood Monica Gratacos Mayora Sébastien Guillaume Yiran Guo Hakon Hakonarson Konstantinos Hatzikotoulas Joanna Hauser Johannes Hebebrand Sietske G Helder Stefan Herms Beate Herpertz-Dahlmann Wolfgang Herzog Laura M Huckins James I Hudson Hartmut Imgart Hidetoshi Inoko Vladimir Janout Susana Jiménez-Murcia Antonio Julià Gursharan Kalsi Deborah Kaminská Leila Karhunen Andreas Karwautz Martien J H Kas James L Kennedy Anna Keski-Rahkonen Kirsty Kiezebrink Youl-Ri Kim Kelly L Klump Gun Peggy S Knudsen Maria C La Via Stephanie Le Hellard Robert D Levitan Dong Li Lisa Lilenfeld Bochao Danae Lin Jolanta Lissowska Jurjen Luykx Pierre J Magistretti Mario Maj Katrin Mannik Sara Marsal Christian R Marshall Morten Mattingsdal Sara McDevitt Peter McGuffin Andres Metspalu Ingrid Meulenbelt Nadia Micali Karen Mitchell Alessio Maria Monteleone Palmiero Monteleone Benedetta Nacmias Marie Navratilova Ioanna Ntalla Julie K O'Toole Roel A Ophoff Leonid Padyukov Aarno Palotie Jacques Pantel Hana Papezova Dalila Pinto Raquel Rabionet Anu Raevuori Nicolas Ramoz Ted Reichborn-Kjennerud Valdo Ricca Samuli Ripatti Franziska Ritschel Marion Roberts Alessandro Rotondo Dan Rujescu Filip Rybakowski Paolo Santonastaso André Scherag Stephen W Scherer Ulrike Schmidt Nicholas J Schork Alexandra Schosser Jochen Seitz Lenka Slachtova P Eline Slagboom Margarita C T Slof-Op't Landt Agnieszka Slopien Sandro Sorbi Beata Świątkowska Jin P Szatkiewicz Ioanna Tachmazidou Elena Tenconi Alfonso Tortorella Federica Tozzi Janet Treasure Artemis Tsitsika Marta Tyszkiewicz-Nwafor Konstantinos Tziouvas Annemarie A van Elburg Eric F van Furth Gudrun Wagner Esther Walton Elisabeth Widen Eleftheria Zeggini Stephanie Zerwas Stephan Zipfel Andrew W Bergen Joseph M Boden Harry Brandt Steven Crawford Katherine A Halmi L John Horwood Craig Johnson Allan S Kaplan Walter H Kaye James Mitchell Catherine M Olsen John F Pearson Nancy L Pedersen Michael Strober Thomas Werge David C Whiteman D Blake Woodside Jakob Grove Anjali K Henders Janne T Larsen Richard Parker Liselotte V Petersen Jennifer Jordan Martin A Kennedy Andreas Birgegård Paul Lichtenstein Claes Norring Mikael Landén Preben Bo Mortensen Renato Polimanti Jeanette N McClintick Amy E Adkins Fazil Aliev Silviu-Alin Bacanu Anthony Batzler Sarah Bertelsen Joanna M Biernacka Tim B Bigdeli Li-Shiun Chen Toni-Kim Clarke Franziska Degenhardt Anna R Docherty Alexis C Edwards Jerome C Foo Louis Fox Josef Frank Laura M Hack Annette M Hartmann Sarah M Hartz Stefanie Heilmann-Heimbach Colin Hodgkinson Per Hoffmann Jouke-Jan Hottenga Bettina Konte Jari Lahti Marius Lahti-Pulkkinen Dongbing Lai Lannie Ligthart Anu Loukola Brion S Maher Hamdi Mbarek Andrew M McIntosh Matthew B McQueen Jacquelyn L Meyers Yuri Milaneschi Teemu Palviainen Roseann E Peterson Euijung Ryu Nancy L Saccone Jessica E Salvatore Sandra Sanchez-Roige Melanie Schwandt Richard Sherva Fabian Streit Jana Strohmaier Nathaniel Thomas Jen-Chyong Wang Bradley T Webb Robbee Wedow Leah Wetherill Amanda G Wills Hang Zhou Jason D Boardman Danfeng Chen Doo-Sup Choi William E Copeland Robert C Culverhouse Norbert Dahmen Louisa Degenhardt Benjamin W Domingue Mark A Frye Wolfgang Gäebel Caroline Hayward Marcus Ising Margaret Keyes Falk Kiefer Gabriele Koller John Kramer Samuel Kuperman Susanne Lucae Michael T Lynskey Wolfgang Maier Karl Mann Satu Männistö Bertram Müller-Myhsok Alison D Murray John I Nurnberger Ulrich Preuss Katri Räikkönen Maureen D Reynolds Monika Ridinger Norbert Scherbaum Marc A Schuckit Michael Soyka Jens Treutlein Stephanie H Witt Norbert Wodarz Peter Zill Daniel E Adkins Dorret I Boomsma Laura J Bierut Sandra A Brown Kathleen K Bucholz E Jane Costello Harriet de Wit Nancy Diazgranados Johan G Eriksson Lindsay A Farrer Tatiana M Foroud Nathan A Gillespie Alison M Goate David Goldman Richard A Grucza Dana B Hancock Kathleen Mullan Harris Victor Hesselbrock John K Hewitt Christian J Hopfer William G Iacono Eric O Johnson Victor M Karpyak Kenneth S Kendler Henry R Kranzler Kenneth Krauter Penelope A Lind Matt McGue James MacKillop Pamela A F Madden Hermine H Maes Patrik K E Magnusson Elliot C Nelson Markus M Nöthen Abraham A Palmer Brenda W J H Penninx Bernice Porjesz John P Rice Marcella Rietschel Brien P Riley Richard J Rose Pei-Hong Shen Judy Silberg Michael C Stallings Ralph E Tarter Michael M Vanyukov Scott Vrieze Tamara L Wall John B Whitfield Hongyu Zhao Benjamin M Neale Tracey D Wade Andrew C Heath Grant W Montgomery Nicholas G Martin Patrick F Sullivan Jaakko Kaprio Gerome Breen Joel Gelernter Howard J Edenberg Cynthia M Bulik Arpana Agrawal

Addict Biol 2020 Feb 16:e12880. Epub 2020 Feb 16.

Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA.

Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [r ], twin-based = 0.23-0. Read More

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http://dx.doi.org/10.1111/adb.12880DOI Listing
February 2020

Regulation of miR-128 in the nucleus accumbens affects methamphetamine-induced behavioral sensitization by modulating proteins involved in neuroplasticity.

Addict Biol 2020 Feb 14:e12881. Epub 2020 Feb 14.

College of Forensic Medicine, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.

Methamphetamine (METH) -induced behavioral sensitization depends on long-term neuroplasticity in the mesolimbic dopamine system, especially in the nucleus accumbens (NAc). miR-128, a brain enriched miRNA, was found to have abilities in regulating neuronal excitability and formation of fear-extinction memory. Here, we aim to identify the role of miR-128 on METH-induced locomotor sensitization of male mice. Read More

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http://dx.doi.org/10.1111/adb.12881DOI Listing
February 2020

Adolescent binge-ethanol accelerates cognitive impairment and β-amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP/PSE mice.

Addict Biol 2020 Feb 11:e12883. Epub 2020 Feb 11.

Departament de Psicobiologia, Universitat de València, Valencia, Spain.

Previous research in rodents suggests that the long-term neurobehavioral disturbances induced by chronic ethanol (EtOH) exposure could be due to endocannabinoid system (ECS) alterations. Moreover, ECS failure has been proposed to mediate the cognitive impairment and β-amyloid production in Alzheimer disease (AD). Thus, in the present study, we evaluated the effects of adolescent EtOH binge drinking on the cognitive disturbances, hippocampal β-amyloid levels, and in the ECS expression on a transgenic mouse model (APP/PSEN, AZ) of AD. Read More

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http://dx.doi.org/10.1111/adb.12883DOI Listing
February 2020

Dual-specificity phosphatase 15 (DUSP15) in the nucleus accumbens is a novel negative regulator of morphine-associated contextual memory.

Addict Biol 2020 Feb 11:e12884. Epub 2020 Feb 11.

Department of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, China.

Drug relapse among addicts often occurs due to the learned association between drug-paired cues and the rewarding effects of these drugs, such as morphine. Contextual memory associated with morphine has a central role in maintenance and relapse. We showed that morphine-conditioned place preference (CPP) activates extracellular-regulated protein kinase (ERK) in the nucleus accumbens (NAc). Read More

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http://dx.doi.org/10.1111/adb.12884DOI Listing
February 2020

Double dissociation of inhibitory effects between the hippocampal TET1 and TET3 in the acquisition of morphine self-administration in rats.

Addict Biol 2020 Feb 7:e12875. Epub 2020 Feb 7.

CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.

The development of opioid addiction involves DNA methylation. Accordingly, the DNA demethylation, induced by ten-eleven translocation (Tet) enzymes, may represent a novel approach to prevent opioid addiction. The present study examined the role of TET1 and TET3 in the development of morphine-seeking behavior in rats. Read More

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http://dx.doi.org/10.1111/adb.12875DOI Listing
February 2020

Common genetic substrates of alcohol and substance use disorder severity revealed by pleiotropy detection against GWAS catalog in two populations.

Addict Biol 2020 Feb 6:e12877. Epub 2020 Feb 6.

Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.

Alcohol and other substance use disorders (AUD and SUD) are complex diseases that are postulated to have a polygenic inheritance and are often comorbid with other disorders. The comorbidities may arise partially through genetic pleiotropy. Identification of specific gene variants accounting for large parts of the variance in these disorders has yet to be accomplished. Read More

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http://dx.doi.org/10.1111/adb.12877DOI Listing
February 2020

Microglia imaging in methamphetamine use disorder: a positron emission tomography study with the 18 kDa translocator protein radioligand [F-18]FEPPA.

Addict Biol 2020 Feb 4:e12876. Epub 2020 Feb 4.

Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

Activation of brain microglial cells, microgliosis, has been linked to methamphetamine (MA)-seeking behavior, suggesting that microglia could be a new therapeutic target for MA use disorder. Animal data show marked brain microglial activation following acute high-dose MA, but microglial status in human MA users is uncertain, with one positron emission tomography (PET) investigation reporting massively and globally increased translocator protein 18 kDa (TSPO; [C-11](R)-PK11195) binding, a biomarker for microgliosis, in MA users. Our aim was to measure binding of a second-generation TSPO radioligand, [F-18]FEPPA, in brain of human chronic MA users. Read More

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http://dx.doi.org/10.1111/adb.12876DOI Listing
February 2020

Amphetamine promotes cortical Up state: Role of adrenergic receptors.

Addict Biol 2020 Jan 31:e12879. Epub 2020 Jan 31.

Department of Pharmaceutical and Administrative Sciences, Loma Linda University School of Pharmacy, Loma Linda, CA, USA.

Cortical neurons oscillate synchronously between the Up and Down state during slow-wave sleep and general anesthesia. Using local-field-potential recording in the rat prefrontal cortex (PFC), we have shown that systemic administration of methylphenidate promotes PFC Up states and reduces PFC slow oscillation, suggesting a depolarizing effect of the drug on PFC neurons. Here, we report that systemic injection of d-amphetamine produced similar effects. Read More

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http://dx.doi.org/10.1111/adb.12879DOI Listing
January 2020

Role of the central amygdala in acupuncture inhibition of methamphetamine-induced behaviors in rats.

Addict Biol 2020 Jan 29:e12862. Epub 2020 Jan 29.

College of Korean Medicine, Daegu Haany University, Daegu, South Korea.

Methamphetamine (METH) enhances dopamine (DA) transmission in the mesolimbic system implicated in its reinforcing effects. Our previous studies have shown that acupuncture attenuates drug-seeking behaviors by modulating GABAergic transmission in the ventral tegmental area and DA release in the nucleus accumbens (NAc) of the striatum. The effects of acupuncture on METH-induced behaviors and its mediation by neural pathways remain a relatively understudied area of research. Read More

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http://dx.doi.org/10.1111/adb.12862DOI Listing
January 2020

Effect of chemogenetic inhibition of lateral habenula neuronal activity on cocaine- and food-seeking behaviors in the rat.

Addict Biol 2020 Jan 29:e12865. Epub 2020 Jan 29.

Department of Psychiatry and Behavioral Sciences, Harborview Medical Sciences, University of Washington, Seattle, Washington, USA.

A major problem in the treatment of cocaine addiction is high rates of relapse. Relapse is often provoked by acute reexposure to cocaine-associated cues or to cocaine itself. The lateral habenula (LHb), an epithalamic nucleus, regulates midbrain dopaminergic systems that are known to be involved in cocaine taking and seeking behaviors. Read More

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http://dx.doi.org/10.1111/adb.12865DOI Listing
January 2020

Anxiety during abstinence from alcohol: A systematic review of rodent and human evidence for the anterior insula's role in the abstinence network.

Addict Biol 2020 Jan 28:e12861. Epub 2020 Jan 28.

Vanderbilt Center for Addiction Research, Vanderbilt University School of Medicine, Nashville, TN, USA.

Alcohol Use Disorder (AUD) is a chronic, relapsing disease that impacts almost a third of Americans. Despite effective treatments for attaining sobriety, the majority of patients relapse within a year, making relapse a substantial barrier to long-term treatment success. A major factor contributing to relapse is heightened negative affect that results from the combination of abstinence-related increases in stress-reactivity and decreases in reward sensitivity. Read More

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http://dx.doi.org/10.1111/adb.12861DOI Listing
January 2020

Recent cannabis use is associated with smaller hippocampus volume: High-resolution segmentation of structural subfields in a large non-clinical sample.

Addict Biol 2020 Jan 28:e12874. Epub 2020 Jan 28.

Department of Psychology, University of Georgia, Athens, Georgia, USA.

There is mixed evidence that individuals who use cannabis have reduced hippocampal and amygdalar gray matter volume, potentially because of small sample sizes and imprecise morphological characterization. New automated segmentation procedures have improved the measurement of these structures and allow better examination of their subfields, which have been linked to distinct aspects of memory and emotion. The current study applies this new segmentation procedure to the Human Connectome Project Young Adult dataset (N = 1080) to investigate associations of cannabis use with gray matter volume in the hippocampus and amygdala. Read More

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http://dx.doi.org/10.1111/adb.12874DOI Listing
January 2020

Social interaction reward in rats has anti-stress effects.

Addict Biol 2020 Jan 26:e12878. Epub 2020 Jan 26.

Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Medical University Innsbruck, Innsbruck, Austria.

Social interaction in an alternative context can be beneficial against drugs of abuse. Stress is known to be a risk factor that can exacerbate the effects of addictive drugs. In this study, we investigated whether the positive effects of social interaction are mediated through a decrease in stress levels. Read More

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http://dx.doi.org/10.1111/adb.12878DOI Listing
January 2020

Aberrant reward prediction errors in young adult at-risk alcohol users.

Addict Biol 2020 Jan 23:e12873. Epub 2020 Jan 23.

School of Psychology, Trinity College Dublin, Dublin, Ireland.

Previous studies suggest that individuals with substance use disorder have abnormally large responses to unexpected outcomes (reward prediction errors [RPEs]). However, there is much less information on RPE in individuals at risk of alcohol misuse, prior to neurobiological adaptations that might result from sustained alcohol use. Here, participants (mean age 23. Read More

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http://dx.doi.org/10.1111/adb.12873DOI Listing
January 2020

Fatty acid amide hydrolase is lower in young cannabis users.

Addict Biol 2020 Jan 20:e12872. Epub 2020 Jan 20.

Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

We have recently shown that levels of fatty acid amide hydrolase (FAAH), the enzyme that metabolizes the endocannabinoid anandamide, are lower in the brains of adult cannabis users (CUs) (34 ± 11 years of age), tested during early abstinence. Here, we examine replication of the lower FAAH levels in a separate, younger cohort (23 ± 5 years of age). Eighteen healthy volunteers (HVs) and fourteen CUs underwent a positron emission tomography scan using the FAAH radioligand [ C]CURB. Read More

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http://dx.doi.org/10.1111/adb.12872DOI Listing
January 2020