1,599 results match your criteria Addiction Biology[Journal]


Cannabidiol modulates the expression of neuroinflammatory factors in stress- and drug-induced reinstatement of methamphetamine in extinguished rats.

Addict Biol 2019 Feb 22. Epub 2019 Feb 22.

Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Methamphetamine (METH) is a highly potent and addictive psychostimulant that is frequently abused worldwide. Although the biggest challenge to the efficient treatment of drug dependence is relapse, its mechanism is completely unclear. Plenty of evidence suggests that inflammation contributes to drug-induced reward especially in brain regions that are involved in the reward system, but there is no document about relapse. Read More

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http://dx.doi.org/10.1111/adb.12740DOI Listing
February 2019

Activation of AMPK-dependent autophagy in the nucleus accumbens opposes cocaine-induced behaviors of mice.

Addict Biol 2019 Feb 20. Epub 2019 Feb 20.

Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Cocaine is a strong central nervous system stimulant, which can induce drug addiction. Previous studies have reported that cocaine-induced autophagy is involved in neuroinflammation and cell death. However, the role of autophagy in psychomotor sensitivity to cocaine has not been explored. Read More

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http://dx.doi.org/10.1111/adb.12736DOI Listing
February 2019

The role of 6-acetylmorphine in heroin-induced reward and locomotor sensitization in mice.

Addict Biol 2019 Feb 20. Epub 2019 Feb 20.

Section for Drug Abuse Research, Department of Forensic Sciences, Oslo University Hospital, Oslo, Norway.

We have previously demonstrated that heroin's first metabolite, 6-acetylmorphine (6-AM), is an important mediator of heroin's acute effects. However, the significance of 6-AM to the rewarding properties of heroin still remains unknown. The present study therefore aimed to examine the contribution of 6-AM to heroin-induced reward and locomotor sensitization. Read More

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http://dx.doi.org/10.1111/adb.12727DOI Listing
February 2019

Role of glucocorticoids on noradrenergic and dopaminergic neurotransmission within the basolateral amygdala and dentate gyrus during morphine withdrawal place aversion.

Addict Biol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pharmacology, University of Murcia, Murcia, Spain.

Aversive memories related to drug withdrawal can generate a motivational state leading to compulsive drug taking. However, the mechanisms underlying the generation of these withdrawal memories remain unclear. Limbic structures, such as the basolateral amygdala (BLA) and the dentate gyrus (DG) of the hippocampus, play a crucial role in the negative affective component of morphine withdrawal. Read More

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http://dx.doi.org/10.1111/adb.12728DOI Listing
February 2019

The influence of sex and estrous cyclicity on cocaine and remifentanil demand in rats.

Addict Biol 2019 Feb 19. Epub 2019 Feb 19.

Department of Psychology, University of Kentucky, Lexington, KY, USA.

The application of behavioral economic demand theory in addiction science has proved useful for evaluating individual characteristics underlying abuse liability. Two factors that have received comparably little attention within this literature are sex and gonadal hormones. We determined cocaine and remifentanil demand in male and female rats using a within-session procedure. Read More

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http://dx.doi.org/10.1111/adb.12716DOI Listing
February 2019

Adolescence versus adulthood: Differences in basal mesolimbic and nigrostriatal dopamine transmission and response to drugs of abuse.

Addict Biol 2019 Feb 18. Epub 2019 Feb 18.

National Research Council of Italy, Institute of Neuroscience, Italy.

Epidemiological studies have shown that people who begin experimenting drugs of abuse during adolescence are more likely to develop substance use disorders, and the earliest is the beginning of their use, the greatest is the likelihood to become dependent. Understanding the neurobiological changes increasing adolescent vulnerability to drug use is becoming imperative. Although all neurotransmitter systems undergo relevant developmental changes, dopamine system is of particular interest, given its role in a variety of functions related to reward, motivation, and decision making. Read More

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http://dx.doi.org/10.1111/adb.12721DOI Listing
February 2019

Neuroimmune and epigenetic involvement in adolescent binge ethanol-induced loss of basal forebrain cholinergic neurons: Restoration with voluntary exercise.

Addict Biol 2019 Feb 18. Epub 2019 Feb 18.

Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Binge drinking and alcohol abuse are common during adolescence and cause lasting pathology. Preclinical rodent studies using the adolescent intermittent ethanol (AIE; 5.0 g/kg, i. Read More

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http://dx.doi.org/10.1111/adb.12731DOI Listing
February 2019

Pharmacological targeting of the GABA receptor alters Drosophila's behavioural responses to alcohol.

Addict Biol 2019 Feb 13. Epub 2019 Feb 13.

Medicines Research Group, University of East London, London, UK.

When exposed to ethanol, Drosophila melanogaster display a variety of addiction-like behaviours similar to those observed in mammals. Sensitivity to ethanol can be quantified by measuring the time at which 50% of the flies are sedated by ethanol exposure (ST50); an increase of ST50 following multiple ethanol exposures is widely interpreted as development of tolerance to ethanol. Sensitivity and tolerance to ethanol were measured after administration of the gamma-aminobutyric acid receptor B (GABA ) agonist (SKF 97541) and antagonist (CGP 54626), when compared with flies treated with ethanol alone. Read More

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http://dx.doi.org/10.1111/adb.12725DOI Listing
February 2019
2 Reads

Ultrahigh-resolution MRI reveals structural brain differences in serotonin transporter knockout rats after sucrose and cocaine self-administration.

Addict Biol 2019 Feb 12. Epub 2019 Feb 12.

Department of Cognitive Neuroscience, Centre for Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboudumc, Nijmegen, The Netherlands.

Excessive use of cocaine is known to induce changes in brain white and gray matter. It is unknown whether the extent of these changes is related to individual differences in vulnerability to cocaine addiction. One factor increasing vulnerability involves reduced expression of the serotonin transporter (5-HTT). Read More

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http://dx.doi.org/10.1111/adb.12722DOI Listing
February 2019
1 Read

Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone.

Addict Biol 2019 Feb 12. Epub 2019 Feb 12.

Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.

During the first weeks of abstinence, alcohol craving in patients may increase or "incubate." We hypothesize that Naltrexone (NTX) blocks this incubation effect. Here, we compared NTX effects on neural alcohol cue reactivity (CR) over the first weeks of abstinence and on long-term clinical outcomes to standard treatment. Read More

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http://dx.doi.org/10.1111/adb.12717DOI Listing
February 2019

Demonstration of critical role of GRIN3A in nicotine dependence through both genetic association and molecular functional studies.

Addict Biol 2019 Feb 11. Epub 2019 Feb 11.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine, China.

Nicotine dependence (ND) is a chronic disease with catastrophic effects on individual and public health. The glutamate receptor subunit gene, ionotropic N-methyl-d-aspartate 3A (GRIN3A), encodes a crucial subunit of N-methyl-d-aspartate receptors (NMDARs), which play an essential role in synaptic plasticity in the brain. Although various variants of GRIN3A have been associated with ND in European-American and African-American samples, no study has been reported for the association between GRIN3A and ND in Chinese Han population. Read More

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http://dx.doi.org/10.1111/adb.12718DOI Listing
February 2019
1 Read

Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice.

Addict Biol 2019 Feb 7. Epub 2019 Feb 7.

Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

In drug addiction, environmental stimuli previously associated with cocaine use readily elicit cocaine-associated memories, which persist long after abstinence and trigger cocaine craving and consumption. Although previous studies suggest that the medial prefrontal cortex (mPFC) is involved in the expression of cocaine-addictive behaviors, it remains unclear whether excitatory and inhibitory neurons in the mPFC are causally related to the formation and retrieval of cocaine-associated memories. To address this issue, we used the designer receptors exclusively activated by designer drugs (DREADD) technology combined with a cocaine-induced conditioned place preference (CPP) paradigm. Read More

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http://dx.doi.org/10.1111/adb.12723DOI Listing
February 2019

N-acetylcysteine yields sex-specific efficacy for cue-induced reinstatement of nicotine seeking.

Addict Biol 2019 Feb 7. Epub 2019 Feb 7.

Department of Psychology, Arizona State University, Tempe, Arizona.

Women report greater craving during certain phases of the menstrual cycle. As well, research indicates that pharmacotherapies for smoking may be less efficacious in women compared with men, which may be due to interactions with natural fluctuations in ovarian hormone levels. N-Acetylcysteine (NAC) is a glutamatergic compound that has shown some efficacy in treating substance use disorders and aids in the prevention of relapse. Read More

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http://doi.wiley.com/10.1111/adb.12711
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http://dx.doi.org/10.1111/adb.12711DOI Listing
February 2019
2 Reads

Cocaine'omics: Genome-wide and transcriptome-wide analyses provide biological insight into cocaine use and dependence.

Addict Biol 2019 Feb 8. Epub 2019 Feb 8.

Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado.

We investigated the genetic and molecular architecture of cocaine dependence (CD) and cocaine use by integrating genome-/transcriptome-wide analyses. To prioritize candidates for follow-up investigation, we also sought to translate gene expression findings across species. Using data from the largest genome-wide association study (GWAS) of CD to date (n = 3176, 74% with CD), we assessed genomic heritability, gene-based associations, and tissue enrichment. Read More

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http://dx.doi.org/10.1111/adb.12719DOI Listing
February 2019

The role of DNA methyltransferase activity in cocaine treatment and withdrawal in the nucleus accumbens of mice.

Addict Biol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pharmacology, Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia.

An increasing number of reports have provided crucial evidence that epigenetic modifications, such as DNA methylation, may be involved in initiating and establishing psychostimulant-induced stable changes at the cellular level by coordinating the expression of gene networks, which then manifests as long-term behavioral changes. In this study, we evaluated the enzyme activity of DNA methyltransferases (DNMTs) after cocaine treatment and during withdrawal. Furthermore, we studied how genetic or pharmacological inhibition of DNMTs in mouse nucleus accumbens (NAc) affects the induction and expression of cocaine-induced behavioral sensitization. Read More

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http://dx.doi.org/10.1111/adb.12720DOI Listing
February 2019

Differential gene expression and stereological analyses of the cerebellum following methamphetamine exposure.

Addict Biol 2019 Feb 4. Epub 2019 Feb 4.

Cell Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Iran.

Methamphetamine (METH) is a highly addictive psychostimulant that profoundly aimed at monoaminergic systems in the brain. Despite the leading role of cerebellum in sensorimotor control as well as augmented locomotor activity under the influence of METH, there are few studies examining the effect of METH administration on gene expression profiling and structural consequences in the cerebellar region. Thus, we sought to explore the effects of METH on the cerebellum, from gene expression changes to structural alterations. Read More

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http://dx.doi.org/10.1111/adb.12707DOI Listing
February 2019

Reconsolidation impairment of reward memory by stimulating stress response.

Addict Biol 2019 Jan 22. Epub 2019 Jan 22.

Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany.

Research in memory reconsolidation has raised hope for new treatment options of persistent psychiatric disorders like substance dependence and post-traumatic stress disorder (PTSD). While animal research showed successful memory modification by interfering with reconsolidation, human research requires less invasive techniques. In our pilot study, we aimed to reduce appetitive memory reconsolidation of a newly acquired reward memory by exerting a stressor. Read More

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http://doi.wiley.com/10.1111/adb.12712
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http://dx.doi.org/10.1111/adb.12712DOI Listing
January 2019
6 Reads

The role of matrix metalloproteinase-9 in negative reinforcement learning and plasticity in alcohol dependence.

Addict Biol 2019 Jan 16. Epub 2019 Jan 16.

Laboratory of Alcoholism and Addictions Neuroscience, Department of Psychology, Alcohol and Drug Abuse Research Program, Translational Addictions Research Center, Washington State University, Pullman, Washington, USA.

A role for matrix metalloproteinases (MMPs) in plasticity-dependent learning has been established. MMPs degrade the extracellular matrix (ECM) when synaptic reorganization is warranted. Previously, we showed that escalation of alcohol self-administration is a learned plasticity-dependent process that requires an intact MMP system. Read More

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http://dx.doi.org/10.1111/adb.12715DOI Listing
January 2019
3 Reads

The role of the paraventricular nucleus of the thalamus in the augmentation of heroin seeking induced by chronic food restriction.

Addict Biol 2019 Jan 9. Epub 2019 Jan 9.

Department of Psychology, Center for Studies in Behavioral Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Canada.

Drug addiction is a chronic disorder that is characterized by compulsive drug seeking and involves cycling between periods of compulsive drug use, abstinence, and relapse. In both human addicts and animal models of addiction, chronic food restriction has been shown to increase rates of relapse. Previously, our laboratory has demonstrated a robust increase in drug seeking following a period of withdrawal in chronically food-restricted rats compared with sated rats. Read More

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http://doi.wiley.com/10.1111/adb.12708
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http://dx.doi.org/10.1111/adb.12708DOI Listing
January 2019
6 Reads

Central nucleus of the amygdala as a common substrate of the incubation of drug and natural reinforcer seeking.

Addict Biol 2019 Jan 8. Epub 2019 Jan 8.

Department of Psychobiology, School of Psychology, UNED, Madrid, Spain.

Relapse into drug use is a major problem faced by recovering addicts. In humans, an intensification of the desire for the drug induced by environmental cues-incubation of drug craving-has been observed. In rodents, this phenomenon has been modeled by studying drug seeking under extinction after different times of drug withdrawal (or using a natural reinforcer). Read More

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http://dx.doi.org/10.1111/adb.12706DOI Listing
January 2019
1 Read

Support vector machine-based multivariate pattern classification of methamphetamine dependence using arterial spin labeling.

Addict Biol 2019 Jan 9. Epub 2019 Jan 9.

Laboratory of Behavioral Neuroscience, Ningbo Addiction Research and Treatment Center, Ningbo, China.

Arterial spin labeling (ASL) magnetic resonance imaging has been widely applied to identify cerebral blood flow (CBF) abnormalities in a number of brain disorders. To evaluate its significance in detecting methamphetamine (MA) dependence, this study used a multivariate pattern classification algorithm, ie, a support vector machine (SVM), to construct classifiers for discriminating MA-dependent subjects from normal controls. Forty-five MA-dependent subjects, 45 normal controls, and 36 heroin-dependent subjects were enrolled. Read More

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http://doi.wiley.com/10.1111/adb.12705
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http://dx.doi.org/10.1111/adb.12705DOI Listing
January 2019
5 Reads

Cue-elicited craving-related lentiform activation during gaming deprivation is associated with the emergence of Internet gaming disorder.

Addict Biol 2019 Jan 6. Epub 2019 Jan 6.

Department of Psychiatry, Department of Neurobiology, and Child Study Center, Yale University School of Medicine, New Haven, Connecticut.

Internet gaming disorder (IGD) is associated with negative health measures. However, little is known regarding the brain mechanisms or cognitive factors that may predict transitions from regular game use (RGU) to IGD. Such knowledge may help identify individuals who are particularly vulnerable to IGD and aid in prevention efforts. Read More

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http://doi.wiley.com/10.1111/adb.12713
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http://dx.doi.org/10.1111/adb.12713DOI Listing
January 2019
10 Reads

Polysubstance addiction vulnerability in mental illness: Concurrent alcohol and nicotine self-administration in the neurodevelopmental hippocampal lesion rat model of schizophrenia.

Addict Biol 2018 Dec 28. Epub 2018 Dec 28.

Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN.

Multiple addictions frequently occur in patients with mental illness. However, basic research on the brain-based linkages between these comorbidities is extremely limited. Toward characterizing the first animal modeling of polysubstance use and addiction vulnerability in schizophrenia, adolescent rats with neonatal ventral hippocampal lesions (NVHLs) and controls had 19 weekdays of 1 hour/day free access to alcohol/sucrose solutions (fading from 10% sucrose to 10% alcohol/2% sucrose on day 10) during postnatal days (PD 35-60). Read More

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http://dx.doi.org/10.1111/adb.12704DOI Listing
December 2018
2 Reads

Subthalamic nucleus mediates the modulation on cocaine self-administration induced by ultrasonic vocalization playback in rats.

Addict Biol 2018 Dec 28. Epub 2018 Dec 28.

Institut de Neurosciences de la Timone, UMR 7289 CNRS and Aix-Marseille Université, Marseille, France.

Drug intake is known to be under the influence of social context. We have recently shown that presence of a peer influences drug intake in both rats and humans. Whether or not social acoustic communications between the peers play a role during cocaine or sucrose self-administration (SA) was investigated here using playback of ultrasonic vocalizations (USVs) at 50 and 22 kHz, conveying, respectively, positive and negative internal affective states in adult rats. Read More

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http://dx.doi.org/10.1111/adb.12710DOI Listing
December 2018
1 Read

Oxytocin inhibits methamphetamine-associated learning and memory alterations by regulating DNA methylation at the Synaptophysin promoter.

Addict Biol 2018 Dec 25. Epub 2018 Dec 25.

Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China.

Methamphetamine (METH) causes memory changes, but the underlying mechanisms are poorly understood. Epigenetic mechanisms, including DNA methylation, can potentially cause synaptic changes in the brain. Oxytocin (OT) plays a central role in learning and memory, but little is known of the impact of OT on METH-associated memory changes. Read More

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http://doi.wiley.com/10.1111/adb.12697
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http://dx.doi.org/10.1111/adb.12697DOI Listing
December 2018
7 Reads

Brain GABA levels are reduced in alcoholic liver disease: A proton magnetic resonance spectroscopy study.

Addict Biol 2018 Dec 18. Epub 2018 Dec 18.

NHMRC Centre of Research Excellence in Mental Health and Substance Use, Central Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.

Background And Aims: Baclofen, a selective γ-aminobutyric acid (GABA) receptor agonist, has emerged as a potential treatment for alcohol use disorder with much unexplained variation in response to treatment efficacy and dose regimen. Several positive studies include patients with alcoholic liver disease (ALD) and/or history of heavy drinking. The aim of this paper was to examine the association of cortical GABA+ concentration with severity of liver disease (including markers of liver injury) and other clinical characteristics in alcohol patients. Read More

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http://dx.doi.org/10.1111/adb.12702DOI Listing
December 2018
2 Reads

How high-dose alcohol intoxication affects the interplay of automatic and controlled processes.

Addict Biol 2018 Dec 18. Epub 2018 Dec 18.

Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Carl Gustav Carus Faculty of Medicine, Dresden, Germany.

Binge drinking is an increasingly prevalent pattern of alcohol consumption that impairs top-down cognitive control to a much stronger degree than automatic response generation. Even though an imbalance of those two antagonistic processes fosters the development and maintenance of alcohol use disorders (AUDs), it has never been directly investigated how binge drinking affects the interaction of those two processes. We therefore assessed a sample of n = 35 healthy young men who were asked to perform a newly developed Simon Nogo paradigm once sober and once intoxicated (~1. Read More

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http://doi.wiley.com/10.1111/adb.12700
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http://dx.doi.org/10.1111/adb.12700DOI Listing
December 2018
2 Reads

Dysfunctional approach behavior triggered by alcohol-unrelated Pavlovian cues predicts long-term relapse in alcohol dependence.

Addict Biol 2018 Dec 18. Epub 2018 Dec 18.

Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Germany.

We demonstrated that alcohol-dependent patients who relapsed within 1 year after detoxification showed stronger PIT effects compared with abstainers and controls. Relapsers particularly failed to correctly perform in trials where an instrumental stimulus required inhibition while a Pavlovian background cue indicated a monetary gain. Under that condition, relapsers approached the instrumental stimulus, independent of the expected punishment. Read More

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http://dx.doi.org/10.1111/adb.12703DOI Listing
December 2018
2 Reads

Stress vulnerability promotes an alcohol-prone phenotype in a preclinical model of sustained depression.

Addict Biol 2018 Dec 18. Epub 2018 Dec 18.

Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam, The Netherlands.

Major depression and alcohol-related disorders frequently co-occur. Depression severity weighs on the magnitude and persistence of comorbid alcohol use disorder (AUD), with severe implications for disease prognosis. Here, we investigated whether depression vulnerability drives propensity to AUD at the preclinical level. Read More

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http://dx.doi.org/10.1111/adb.12701DOI Listing
December 2018
2 Reads

The Fyn kinase inhibitor, AZD0530, suppresses mouse alcohol self-administration and seeking.

Addict Biol 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurology, University of California San Francisco, San Francisco, California.

Fyn is a member of the Src family of protein tyrosine kinases (PTKs) that plays an important role not only in normal synaptic functions but also in brain pathologies including alcohol use disorder. We previously reported that repeated cycles of binge drinking and withdrawal activate Fyn in the dorsomedial striatum (DMS) of rodents, and that Fyn signaling in the DMS contributes to rat alcohol intake and relapse. Here, we used AZD0530, a CNS penetrable inhibitor of Src PTKs developed for the treatment of Alzheimer disease and cancer and tested its efficacy to suppress alcohol-dependent molecular and behavioral effects. Read More

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http://dx.doi.org/10.1111/adb.12699DOI Listing
December 2018
3 Reads

Larry Parsons: Researcher, mentor, and friend.

Addict Biol 2018 Nov;23(6):1204-1206

Instituto IBIMA, Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain.

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http://dx.doi.org/10.1111/adb.12686DOI Listing
November 2018
3 Reads

Shifts in the functional topography of frontal cortex-striatum connectivity in alcohol use disorder.

Addict Biol 2018 Nov 23. Epub 2018 Nov 23.

Department of Clinical Psychology, Central Institute of Mental Health, University of Heidelberg/Medical Faculty Mannheim, Mannheim, Germany.

Frontostriatal circuits are centrally involved in the selection of behavioral programs and play a prominent role in alcohol use disorder (AUD) as well as other mental disorders. However, how frontal regions change their striatal connectivity to implement adaptive cognitive control is still not fully understood. Here, we developed an approach for functional magnetic resonance imaging (fMRI) connectivity analysis in which we change the focus from connectivity to individual voxels towards spatial information about the location of strongest functional connectivity. Read More

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http://dx.doi.org/10.1111/adb.12692DOI Listing
November 2018
8 Reads

Sex-dependent differences in ethanol inhibition of mouse lateral orbitofrontal cortex neurons.

Addict Biol 2018 Nov 23. Epub 2018 Nov 23.

Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina.

Biological differences between males and females likely influence responses to alcohol and the propensity to engage in excessive drinking. In both humans and rodents, females escalate alcohol use and develop addiction-like behaviors faster than males, while males exhibit more severe withdrawal symptoms during abstinence. The mechanisms underlying these differences are not yet known but may reflect fundamental differences in the ethanol sensitivity of neurons in reward and control areas of the brain. Read More

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http://dx.doi.org/10.1111/adb.12698DOI Listing
November 2018
4 Reads

PI3K activation within ventromedial prefrontal cortex regulates the expression of drug-seeking in two rodent species.

Addict Biol 2018 Nov 18. Epub 2018 Nov 18.

Department of Psychological and Brain Sciences, University of California Santa Barbara, Santa Barbara, California.

Phosphatidylinositide 3-kinases (PI3Ks) are intracellular signal transducer enzymes that recruit protein kinase B (aka Akt) to the cell membrane, the subsequent activation of which regulates many cellular functions. PI3K/Akt activity is up-regulated within mesocorticolimbic structures in animal models of alcoholism, but less is known regarding PI3K/Akt activity in animal models of cocaine addiction. Given that prefrontal cortex (PFC) is grossly dysregulated in addiction, we studied how cocaine affects protein indices of PFC PI3K/Akt activity in rat and mouse models and examined the relevance of PI3K activity for cocaine-related learning. Read More

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http://dx.doi.org/10.1111/adb.12696DOI Listing
November 2018
12 Reads

GABA receptor positive allosteric modulators with different efficacies affect neuroadaptation to and self-administration of alcohol and cocaine.

Addict Biol 2018 Nov 13. Epub 2018 Nov 13.

Department of Pharmacology, Faculty of Medicine, University of Helsinki, Finland.

Drugs of abuse induce widespread synaptic adaptations in the mesolimbic dopamine (DA) neurons. Such drug-induced neuroadaptations may constitute an initial cellular mechanism eventually leading to compulsive drug-seeking behavior. To evaluate the impact of GABA receptors on addiction-related persistent neuroplasticity, we tested the ability of orthosteric agonist baclofen and two positive allosteric modulators (PAMs) of GABA receptors to suppress neuroadaptations in the ventral tegmental area (VTA) and reward-related behaviors induced by ethanol and cocaine. Read More

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http://doi.wiley.com/10.1111/adb.12688
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http://dx.doi.org/10.1111/adb.12688DOI Listing
November 2018
13 Reads

Stress responding and stress-related changes in cue reactivity in heavy smokers, problem gamblers, and healthy controls.

Addict Biol 2018 Nov 13. Epub 2018 Nov 13.

University at Albany, State University of New York, Albany, New York.

Addictions, both substance and behavioral, have been conceptualized as involving similar biopsychosocial processes with different opportunistic expressions. A maladaptive stress response in combination with craving or urges to engage in the addictive behavior may be among the underlying factors common to behavioral and substance addictions. The current study compared the neuroendocrine (cortisol) and subjective responses to stress of gamblers and smokers to healthy controls. Read More

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http://doi.wiley.com/10.1111/adb.12687
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http://dx.doi.org/10.1111/adb.12687DOI Listing
November 2018
17 Reads

Cannabinoid dependence induces sustained changes in GABA release in the globus pallidus without affecting dopamine release in the dorsal striatum: A dual microdialysis probe study.

Addict Biol 2018 Nov 13;23(6):1251-1261. Epub 2018 Nov 13.

Laboratorio de Neuropsicofarmacología, Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga, Hospital Regional Universitario de Málaga, Málaga, Spain.

A dual probe microdialysis study was designed to characterize GABA and dopamine (DA) release in the basal ganglia of cannabinoid-dependent Wistar rats. Whereas chronic administration of the cannabinoid receptor agonist WIN55,212 (WIN) resulted in increased basal GABA release, the D2 agonist receptor-mediated control of GABA and DA release elicited by quinpirole was similar in both cannabinoid-dependent and non dependent animals. However, quinpirole did induce a greater number of more stereotypies in cannabinoid-dependent animals, indicating a dysregulated behavioral response. Read More

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http://dx.doi.org/10.1111/adb.12694DOI Listing
November 2018
4 Reads

ARC and BDNF expression after cocaine self-administration or cue-induced reinstatement of cocaine seeking in adolescent and adult male rats.

Addict Biol 2018 Nov 12;23(6):1233-1241. Epub 2018 Nov 12.

Neuroscience Institute, Georgia State University, Atlanta, GA, USA.

Recreational drug use peaks during adolescence. Our research with adolescent vs adult male rats, however, shows that rats taking cocaine as adolescents have lower levels of cue-induced reinstatement of drug-seeking than adults, despite similar levels of intravenous (i.v. Read More

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http://dx.doi.org/10.1111/adb.12689DOI Listing
November 2018
1 Read

Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice.

Addict Biol 2018 Nov 13. Epub 2018 Nov 13.

Department of Neuroscience, The Scripps Research Institute, La Jolla, California, USA.

Deletion of fatty acid amide hydrolase (FAAH), enzyme responsible for degrading endocannabinoids, increases alcohol consumption and preference. However, there is a lack of data on neurochemical events in mice exposed to alcohol in the absence of FAAH. Extracellular levels of endocannabinoids and relevant neurotransmitters were measured by in vivo microdialysis in the nucleus accumbens (NAc) of FAAH knockout (KO) and wild-type (WT) mice during an ethanol (EtOH; 2 g/kg, ip) challenge in EtOH-naive and repeated (r) EtOH-treated mice. Read More

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http://doi.wiley.com/10.1111/adb.12695
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http://dx.doi.org/10.1111/adb.12695DOI Listing
November 2018
13 Reads

Overexpression of ASIC1A in the nucleus accumbens of rats potentiates cocaine-seeking behavior.

Addict Biol 2018 Nov 6. Epub 2018 Nov 6.

Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA.

Acid-sensing ion channels (ASICs) are abundantly expressed in the nucleus accumbens core (NAcore), a region of the mesolimbocortical system that has an established role in regulating drug-seeking behavior. Previous work shows that a single dose of cocaine reduced the AMPA-to-NMDA ratio in Asic1a mice, an effect observed after withdrawal in wild-type mice, whereas ASIC1A overexpression in the NAcore of rats decreases cocaine self-administration. However, whether ASIC1A overexpression in the NAcore alters measures of drug-seeking behavior after the self-administration period is unknown. Read More

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http://doi.wiley.com/10.1111/adb.12690
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http://dx.doi.org/10.1111/adb.12690DOI Listing
November 2018
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Neuronal nicotinic acetylcholine receptors mediate ∆ -THC dependence: Mouse and human studies.

Addict Biol 2018 Oct 31. Epub 2018 Oct 31.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.

Cessation from prolonged use of ∆ -tetrahydrocannabinol (THC), the primary active compound responsible for the cannabimimetic effects of cannabis, results in a mild to moderate withdrawal syndrome in humans and laboratory animals. Whereas manipulations of the endogenous cannabinoid system (eg, cannabinoid receptors and endocannabinoid regulating enzymes) alter nicotine withdrawal, in this study we asked the reciprocal question. Do nicotinic acetylcholine receptors (nAChRs) modulate THC withdrawal? To assess the role of different nAChR subtypes in THC withdrawal, we used transgenic mouse, preclinical pharmacological, and human genetic correlation approaches. Read More

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http://dx.doi.org/10.1111/adb.12691DOI Listing
October 2018
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Special issue honoring the legacy of Loren H. Parsons.

Addict Biol 2018 Nov 31;23(6):1203. Epub 2018 Oct 31.

Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga, Hospital Regional Universitario de Málaga, Málaga, Spain.

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http://doi.wiley.com/10.1111/adb.12693
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http://dx.doi.org/10.1111/adb.12693DOI Listing
November 2018
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Varenicline and nabilone in tobacco and cannabis co-users: effects on tobacco abstinence, withdrawal and a laboratory model of cannabis relapse.

Addict Biol 2018 Oct 31. Epub 2018 Oct 31.

Division on Substance Use Disorders, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY, USA.

Tobacco and cannabis co-users (T+CUs) have poor cannabis cessation outcomes, but the mechanisms underlying this are not well understood. This laboratory study examined the effects of (1) the partial nicotinic agonist, varenicline, on tobacco cessation among T+CUs, and (2) varenicline, alone, and when combined with the cannabinoid agonist nabilone, on cannabis withdrawal and a laboratory model of cannabis relapse. Non-treatment-seeking T+CUs were randomized to active-varenicline or placebo-varenicline, and completed a 15-day outpatient phase; varenicline was titrated to 1 mg BID during days 1-8, and participants were instructed to abstain from tobacco during days 9-15. Read More

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http://dx.doi.org/10.1111/adb.12664DOI Listing
October 2018
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A dual-process exploration of binge drinking: Evidence through behavioral and electrophysiological findings.

Addict Biol 2018 Oct 29. Epub 2018 Oct 29.

Laboratory for Experimental Psychopathology (LEP), Psychological Science Research Institute, Université catholique de Louvain, Louvain-la-Neuve, Belgium.

The dual-process model, describing addictive disorders as resulting from an imbalance between increased automatic approach behaviors towards the substance and reduced abilities to control these behaviors, constitutes a sound theoretical framework to understand alcohol-use disorders. The present study aimed at exploring this imbalance at behavioral and cerebral levels in binge drinking, a pattern of excessive alcohol consumption frequently observed in youth, by assessing both reflective control abilities and automatic processing of alcohol-related stimuli. For this purpose, 25 binge drinkers and 25 comparison participants performed a Go/No-Go task during electrophysiological recording. Read More

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http://doi.wiley.com/10.1111/adb.12685
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http://dx.doi.org/10.1111/adb.12685DOI Listing
October 2018
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DRD2 methylation is associated with executive control network connectivity and severity of alcohol problems among a sample of polysubstance users.

Addict Biol 2018 Oct 29. Epub 2018 Oct 29.

Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado.

Chronic exposure to alcohol and other drugs of abuse has been associated with deleterious consequences, including functional connectivity deficits within neural networks associated with executive control. Altered functional connectivity within the executive control network (ECN) might underlie the progressive inability to control consumption of alcohol and other drugs as substance use disorders progress. Genetic and epigenetic factors have been associated with substance use disorders (SUDs). Read More

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http://doi.wiley.com/10.1111/adb.12684
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http://dx.doi.org/10.1111/adb.12684DOI Listing
October 2018
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Ethanol consumption following mild traumatic brain injury is related to blood-brain barrier permeability.

Addict Biol 2018 Oct 18. Epub 2018 Oct 18.

Laboratory of Neurogenomics, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Magdalenka, Poland.

Several preclinical and clinical studies that deal with the neuropathological consequences of mild traumatic brain injury (mTBI) have focused on unraveling its effect on ethanol drinking behavior. Previous reports describe changes in ethanol consumption, both in animal models of mTBI as well as in patients, after concussive brain injury. However, the neurobiological mechanisms underlying this phenomenon are still poorly understood. Read More

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http://doi.wiley.com/10.1111/adb.12683
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http://dx.doi.org/10.1111/adb.12683DOI Listing
October 2018
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Social motivational processing and interpersonal function in aging cocaine smokers.

Addict Biol 2018 Oct 17. Epub 2018 Oct 17.

Department of Psychiatry, Columbia University Medical Center and New York State Psychiatric Institute, New York, NY, USA.

Illicit drug use among aging cohorts is increasing, yet little is known about functional impairments in older drug users. Given the importance of social integration for aging and documented social decrements in cocaine users, we examined social function and its neurocognitive substrates in aging cocaine users relative to carefully matched non-cocaine users. Regular (≥twice/week), long-term (≥15 years) cocaine smokers 50-60 years old (COCs; n = 22; four women) and controls (CTRLs; n = 19; four women) underwent standardized probes of social reward and threat processing during functional magnetic resonance imaging and a behavioral facial affect recognition task. Read More

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http://doi.wiley.com/10.1111/adb.12669
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http://dx.doi.org/10.1111/adb.12669DOI Listing
October 2018
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phMRI, neurochemical and behavioral responses to psychostimulants distinguishing genetically selected alcohol-preferring from genetically heterogenous rats.

Addict Biol 2018 Oct 17. Epub 2018 Oct 17.

Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy.

Alcoholism is often associated with other forms of drug abuse, suggesting that innate predisposing factors may confer vulnerability to addiction to diverse substances. However, the neurobiological bases of these factors remain unknown. Here, we have used a combination of imaging, neurochemistry and behavioral techniques to investigate responses to the psychostimulant amphetamine in Marchigian Sardinian (msP) alcohol-preferring rats, a model of vulnerability to alcoholism. Read More

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http://dx.doi.org/10.1111/adb.12671DOI Listing
October 2018
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Cannabidiol affects circadian clock core complex and its regulation in microglia cells.

Addict Biol 2018 Oct 11. Epub 2018 Oct 11.

Dpt Addictologie, AP-HP, GH Paris-Sud, Hôpital Paul Brousse, Villejuif, France.

Cannabis is often used by consumers for sleep disorders. Studies show that circadian rhythm could be affected by a misuse of cannabis. Recent research has connected the role of microglial cells with psychiatric disorders such as substance abuse. Read More

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http://doi.wiley.com/10.1111/adb.12660
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http://dx.doi.org/10.1111/adb.12660DOI Listing
October 2018
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Neural basis of smoking-induced relief of craving and negative affect: Contribution of nicotine.

Addict Biol 2018 Oct 11. Epub 2018 Oct 11.

Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California.

Smoking-induced relief of craving and withdrawal promotes continued cigarette use. Understanding how relief is produced and the role of nicotine in this process may facilitate development of new smoking-cessation therapies. As the US Food and Drug Administration considers setting a standard for reduced nicotine content in cigarettes to improve public health, knowledge of how nicotine contributes to relief also can inform policy. Read More

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http://doi.wiley.com/10.1111/adb.12679
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http://dx.doi.org/10.1111/adb.12679DOI Listing
October 2018
4 Reads