1,623 results match your criteria Addiction Biology[Journal]


Pharmacokinetics of N-ethylpentylone and its effect on increasing levels of dopamine and serotonin in the nucleus accumbens of conscious rats.

Addict Biol 2019 Apr 15:e12755. Epub 2019 Apr 15.

Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, China.

N-Ethylpentylone (NEP) is one of the most confiscated synthetic cathinones in the world. However, its pharmacology and pharmacokinetics remain largely unknown. In this study, the pharmacokentics of NEP in rat nucleus accumbens (NAc) was assessed via brain microdialysis after the intraperitoneal (ip) administration of NEP (20 or 50 mg/kg). Read More

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http://dx.doi.org/10.1111/adb.12755DOI Listing

Nicotine-induced neuroplasticity in striatum is subregion-specific and reversed by motor training on the rotarod.

Addict Biol 2019 Apr 10:e12757. Epub 2019 Apr 10.

Addiction Biology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Nicotine is recognized as one of the most addictive drugs, which in part could be attributed to progressive neuroadaptations and rewiring of dorsal striatal circuits. Since motor-skill learning produces neuroplasticity in the same circuits, we postulate that rotarod training could be sufficient to block nicotine-induced rewiring and thereby prevent long-lasting impairments of neuronal functioning. To test this hypothesis, Wistar rats were subjected to 15 days of treatment with either nicotine (0. Read More

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http://dx.doi.org/10.1111/adb.12757DOI Listing
April 2019
1 Read

Inhibitory transmission in the bed nucleus of the stria terminalis in male and female mice following morphine withdrawal.

Addict Biol 2019 Apr 9. Epub 2019 Apr 9.

Bowles Center for Alcohol Studies, UNC Chapel Hill School of Medicine, Chapel Hill, NC, USA.

The United States is experiencing an opioid crisis imposing enormous fiscal and societal costs and driving the staggering overdose death rate. While prescription opioid analgesics are essential for treating acute pain, cessation of use in individuals with a physical dependence induces an aversive withdrawal syndrome that promotes continued drug use to alleviate/avoid these symptoms. Additionally, repeated bouts of withdrawal often lead to an increased propensity for relapse. Read More

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http://dx.doi.org/10.1111/adb.12748DOI Listing
April 2019
1 Read

Respective influence of current alcohol consumption and duration of heavy drinking on brain morphological alterations in alcohol use disorder.

Addict Biol 2019 Apr 9:e12751. Epub 2019 Apr 9.

Institute of Neuroscience, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.

Numerous studies have explored the morphological differences of the brain between subjects with alcohol use disorder (AUD) and control subjects, but very few have investigated the impact of the duration of alcohol use disorder (DAD) and current level of alcohol consumption (CAC) within AUD subjects using magnetic resonance imaging (MRI). We compared the morphological MRI of 44 controls and 66 AUD subjects, recruited at the end of a detoxification program. Additional analyses within the AUD group determined which specific alterations were respectively associated with DAD and CAC using: (1) Bonferroni-corrected multivariable linear regressions to explore the DAD/CAC impact on brain volumes and (2) a general linear model (GLM module of FreeSurfer's Qdec) and Monte Carlo simulation to correct for multiple comparisons (P < 0. Read More

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http://dx.doi.org/10.1111/adb.12751DOI Listing
April 2019
1 Read

Cannabis-dependent adolescents show differences in global reward-associated network topology: A functional connectomics approach.

Addict Biol 2019 Apr 8:e12752. Epub 2019 Apr 8.

School of Psychology and Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.

Adolescence may be a period of increased vulnerability to the onset of drug misuse and addiction due to changes in developing brain networks that support cognitive and reward processing. Cannabis is a widely misused illicit drug in adolescence which can lead to dependence and alterations in reward-related neural functioning. Concerns exist that cannabis-related alterations in these reward networks in adolescence may sensitize behaviour towards all forms of reward that increase the risk of further drug use. Read More

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http://dx.doi.org/10.1111/adb.12752DOI Listing

Inhibitory effects of Shati/Nat8l overexpression in the medial prefrontal cortex on methamphetamine-induced conditioned place preference in mice.

Addict Biol 2019 Apr 5. Epub 2019 Apr 5.

Department of Pharmaceutical Therapy and Neuropharmacology, Faculty of Pharmaceutical Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.

Shati/Nat8l is a novel N-acetyltransferase identified in the brain of mice treated with methamphetamine (METH). Shati/Nat8l mRNA is expressed in various brain areas, including the prefrontal cortex (PFC), where the expression level is higher than that in other brain regions. Shati/Nat8l overexpression in the nucleus accumbens (NAc) attenuates the pharmacological response to METH via mGluR3. Read More

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http://dx.doi.org/10.1111/adb.12749DOI Listing
April 2019
1 Read

DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats.

Addict Biol 2019 Apr 5. Epub 2019 Apr 5.

CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.

Drug-reinforced excessive operant responding is one fundamental feature of long-lasting addiction-like behaviors and relapse in animals. However, the transcriptional regulatory mechanisms responsible for the persistent drug-specific (not natural rewards) operant behavior are not entirely clear. In this study, we demonstrate a key role for one of the de novo DNA methyltransferase, DNMT3a, in the acquisition of morphine self-administration (SA) in rats. Read More

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http://dx.doi.org/10.1111/adb.12730DOI Listing

Impaired frontostriatal functional connectivity among chronic opioid using pain patients is associated with dysregulated affect.

Addict Biol 2019 Apr 4. Epub 2019 Apr 4.

Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.

Preclinical studies have shown effects of chronic exposure to addictive drugs on glutamatergic-mediated neuroplasticity in frontostriatal circuitry. These initial findings have been paralleled by human functional magnetic resonance imaging (fMRI) research demonstrating weaker frontostriatal resting-state functional connectivity (rsFC) among individuals with psychostimulant use disorders. However, there is a dearth of human imaging literature describing associations between long-term prescription opioid use, frontostriatal rsFC, and brain morphology among chronic pain patients. Read More

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http://dx.doi.org/10.1111/adb.12743DOI Listing
April 2019
2 Reads

Different pharmaceutical preparations of Δ -tetrahydrocannabinol differentially affect its behavioral effects in rats.

Addict Biol 2019 Apr 2. Epub 2019 Apr 2.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Based on the contribution of the endocannabinoid system to the pathophysiology of schizophrenia, the primary pro-psychotic ingredient of Cannabis sativa, Δ-9-tetrahydrocannabinol (Δ-9-THC), is used in preclinical as well as clinical research to mimic schizophrenia-like symptoms. While it is common to administer lipid-based formulations of Δ-9-THC in human studies orally, intraperitoneal injections of water-based solutions are used in animal models. Because of the poor water solubility of Δ-9-THC, solubilizers such as ethanol and/or emulsifiers are needed for these preparations. Read More

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http://dx.doi.org/10.1111/adb.12745DOI Listing
April 2019
3 Reads

Accelerated aging and motor control deficits are related to regional deformation of central cerebellar white matter in alcohol use disorder.

Addict Biol 2019 Apr 1. Epub 2019 Apr 1.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.

The World Health Organization estimates a 12-month prevalence rate of 8+% for an alcohol use disorder (AUD) diagnosis in people age 15 years and older in the United States and Europe, presenting significant health risks that have the potential of accelerating age-related functional decline. According to neuropathological studies, white matter systems of the cerebellum are vulnerable to chronic alcohol dependence. To pursue the effect of AUD on white matter structure and functions in vivo, this study used T1-weighted, magnetic resonance imaging (MRI) to quantify the total corpus medullare of the cerebellum and a finely grained analysis of its surface in 135 men and women with AUD (mean duration of abstinence, 248 d) and 128 age- and sex-matched control participants; subsets of these participants completed motor testing. Read More

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http://dx.doi.org/10.1111/adb.12746DOI Listing
April 2019
2 Reads

Inhibitory-control event-related potentials correlate with individual differences in alcohol use.

Addict Biol 2019 Mar 27. Epub 2019 Mar 27.

School of Psychology, Trinity College Dublin, Dublin, Ireland.

Impulsivity is a multidimensional construct that is related to different aspects of alcohol use, abuse, and dependence. Inhibitory control, one facet of impulsivity, can be assayed using the stop-signal task (SST) and quantified behaviorally via the stop-signal reaction time (SSRT) and electrophysiologically using event-related potentials (ERPs). Research on the relationship between alcohol use and SSRTs, and between alcohol use and inhibitory-control ERPs, is mixed. Read More

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http://dx.doi.org/10.1111/adb.12729DOI Listing
March 2019
2 Reads

Aberrant insular cortex connectivity in abstinent alcohol-dependent rats is reversed by dopamine D3 receptor blockade.

Addict Biol 2019 Mar 24. Epub 2019 Mar 24.

Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Rovereto, Italy.

A few studies have reported aberrant functional connectivity in alcoholic patients, but the specific neural circuits involved remain unknown. Moreover, it is unclear whether these alterations can be reversed upon treatment. Here, we used functional MRI to study resting state connectivity in rats following chronic intermittent exposure to ethanol. Read More

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http://dx.doi.org/10.1111/adb.12744DOI Listing
March 2019
4 Reads

Addiction theory matters-Why there is no dependence on caffeine or antidepressant medication.

Addict Biol 2019 Mar 21. Epub 2019 Mar 21.

Department of Biomedical Science, Università degli studi di Cagliari, Cagliari, Italy.

With the development of the ICD-11, the debate about classifying certain psychoactive substances such as antidepressant medication and caffeine as drugs of dependence is ignited again. We argue that any coherent theory of addiction needs to identify the neurobiological processes elicited by a potentially addictive substance and to clearly define the clinical symptoms associated with these processes, which can then be used to guide diagnosis. Tolerance development and withdrawal symptoms can occur with any pharmacologically active agent, and their presence is not a sufficient criterion for the clinical diagnosis of an addictive disorder. Read More

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http://dx.doi.org/10.1111/adb.12735DOI Listing

Lateral septum inhibition reduces motivation for cocaine: Reversal by diazepam.

Addict Biol 2019 Mar 21. Epub 2019 Mar 21.

Brain Health Institute, Rutgers University/Rutgers Biomedical and Health Sciences, Piscataway, NJ, USA.

The lateral septum (LS) is a brain region implicated in motivation, addiction, anxiety, and affect. We recently found that LS is necessary for cocaine-seeking behaviors including conditioned place preference and reinstatement of extinguished drug seeking, which involve LS input to limbic regions including ventral tegmental area (VTA) and orexin neurons in hypothalamus. Here, we microinjected baclofen-muscimol (B-M) in LS prior to testing in a behavioral economics (BE) paradigm. Read More

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http://dx.doi.org/10.1111/adb.12742DOI Listing

Phase locking of event-related oscillations is decreased in both young adult humans and rats with a history of adolescent alcohol exposure.

Addict Biol 2019 Mar 18. Epub 2019 Mar 18.

Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.

Alcohol exposure typically begins in adolescence, and frequent binge drinking has been associated with health risk behaviors including alcohol use disorders (AUDs). Few studies have documented the effects of a history of adolescent binge drinking on neurophysiological consequences in young adulthood. Synchrony of phase (phase locking (PL)) of event-related oscillations (EROs) within and between different brain areas reflects communication exchange between neural networks and is a sensitive measure of adolescent development in both rats and humans, and thus may be a good translational measure of the potential harmful effects of alcohol exposure during adolescence. Read More

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http://dx.doi.org/10.1111/adb.12732DOI Listing
March 2019
2 Reads

Influence of nonsynaptic α1 glycine receptors on ethanol consumption and place preference.

Addict Biol 2019 Mar 18. Epub 2019 Mar 18.

Laboratory of Neurophysiology, Department of Physiology, Universidad de Concepcion, Concepcion, Chile.

Here, we used knock-in (KI) mice that have ethanol-insensitive alpha 1 glycine receptors (GlyRs) (KK385/386AA) to examine how alpha 1 GlyRs might affect binge drinking and conditioned place preference. Data show that tonic alpha 1 GlyR-mediated currents were exclusively sensitive to ethanol only in wild-type mice. Behavioral studies showed that the KI mice have a higher intake of ethanol upon first exposure to drinking and greater conditioned place preference to ethanol. Read More

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http://dx.doi.org/10.1111/adb.12726DOI Listing
March 2019
4 Reads

Impaired decision making following escalation of cocaine self-administration predicts vulnerability to relapse in rats.

Addict Biol 2019 Mar 7. Epub 2019 Mar 7.

Department of Psychology, University of Cambridge, Cambridge, UK.

Impairments in cost-benefit decision making represent a cardinal feature of drug addiction. However, whether these alterations predate drug exposure, thereby contributing to facilitating loss of control over drug intake, or alternatively arise as a result of drug use and subsequently confer vulnerability to relapse has yet to be determined. Male Sprague-Dawley rats were trained to self-administer (SA) cocaine during 19 daily long-access (12-h) sessions; conditions reliably shown to promote escalation. Read More

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http://dx.doi.org/10.1111/adb.12738DOI Listing

High-risk social drinkers and heavy drinkers display similar rates of alcohol consumption.

Addict Biol 2019 Mar 1. Epub 2019 Mar 1.

Section on Human Psychopharmacology, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.

Alcohol consumption is often assessed over weeks to months, but few attempts have been made to characterize alcohol consumption rates at the level of an individual drinking session. Here, we aimed to compare the rate of alcohol consumption in social drinkers at high risk for alcohol use disorder (AUD) and heavy drinkers. One hundred and sixty social drinkers and 48 heavy drinkers participated in an alcohol self-administration study. Read More

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http://dx.doi.org/10.1111/adb.12734DOI Listing
March 2019
3 Reads

Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity.

Addict Biol 2019 Feb 27. Epub 2019 Feb 27.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, M5S 1A8, Canada.

The nicotine metabolite ratio (NMR; 3-hydroxycotinine/cotinine) is an index of CYP2A6 activity. CYP2A6 is responsible for nicotine's metabolic inactivation and variation in the NMR/CYP2A6 is associated with several smoking behaviors. Our aim was to integrate established alleles and novel genome-wide association studies (GWAS) signals to create a weighted genetic risk score (wGRS) for the CYP2A6 gene for European-ancestry populations. Read More

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http://dx.doi.org/10.1111/adb.12741DOI Listing
February 2019
2 Reads

HDAC superfamily promoters acetylation is differentially regulated by modafinil and methamphetamine in the mouse medial prefrontal cortex.

Addict Biol 2019 Feb 27. Epub 2019 Feb 27.

Instituto de Investigaciones Farmacológicas, Universidad de Buenos Aires - Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.

Dysregulation of histone deacetylases (HDAC) has been proposed as a potential contributor to aberrant transcriptional profiles that can lead to changes in cognitive functions. It is known that METH negatively impacts the prefrontal cortex (PFC) leading to cognitive decline and addiction whereas modafinil enhances cognition and has a low abuse liability. We investigated if modafinil (90 mg/kg) and methamphetmine (METH) (1 mg/kg) may differentially influence the acetylation status of histones 3 and 4 (H3ac and H4ac) at proximal promoters of class I, II, III, and IV HDACs. Read More

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http://dx.doi.org/10.1111/adb.12737DOI Listing
February 2019

Cerebellar alterations in cannabis users: A systematic review.

Addict Biol 2019 Feb 27. Epub 2019 Feb 27.

Grup de Recerca en Addiccions Clínic (GRAC), Institut Clínic de Neurociències, Barcelona, Spain.

Cannabis is the most used illicit substance in the world. As many countries are moving towards decriminalization, it is crucial to determine whether and how cannabis use affects human brain and behavior. The role of the cerebellum in cognition, emotion, learning, and addiction is increasingly recognized. Read More

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http://dx.doi.org/10.1111/adb.12714DOI Listing
February 2019

Fetus morphology changes by second-trimester ultrasound in pregnant women drinking alcohol.

Addict Biol 2019 Feb 27. Epub 2019 Feb 27.

Centro Riferimento Alcologico Regione Lazio, Sapienza University of Rome, Rome, Italy.

Fetal alcohol spectrum disorders (FASDs) are a group of negative conditions occurring in children exposed to alcohol during gestation. The early discovery of FASD is crucial for mother and infant follow-ups. In this study, we investigated in pregnant women the association between urine ethylglucuronide (EtG-a biomarker of alcohol drinking) and indicators of the physical characteristics of FASD by prenatal ultrasound in the second trimester of gestation. Read More

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http://dx.doi.org/10.1111/adb.12724DOI Listing
February 2019
1 Read

Neural cue reactivity during acute abstinence predicts short-term smoking relapse.

Addict Biol 2019 Feb 25. Epub 2019 Feb 25.

Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.

In smokers, neural responses to smoking cues can be sensitive to acute abstinence, but the degree to which abstinence-related cue reactivity contributes to relapse is not fully understood. This study addressed this question in a sample of 75 smokers who were motivated to quit smoking. Participants underwent blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) during presentation of visual smoking cues and neutral stimuli on two occasions: once during smoking satiety and once following 24-hour abstinence (order counterbalanced). Read More

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http://dx.doi.org/10.1111/adb.12733DOI Listing
February 2019
6 Reads

Cannabidiol modulates the expression of neuroinflammatory factors in stress- and drug-induced reinstatement of methamphetamine in extinguished rats.

Addict Biol 2019 Feb 22. Epub 2019 Feb 22.

Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Methamphetamine (METH) is a highly potent and addictive psychostimulant that is frequently abused worldwide. Although the biggest challenge to the efficient treatment of drug dependence is relapse, its mechanism is completely unclear. Plenty of evidence suggests that inflammation contributes to drug-induced reward especially in brain regions that are involved in the reward system, but there is no document about relapse. Read More

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http://dx.doi.org/10.1111/adb.12740DOI Listing
February 2019
1 Read

Activation of AMPK-dependent autophagy in the nucleus accumbens opposes cocaine-induced behaviors of mice.

Addict Biol 2019 Feb 20. Epub 2019 Feb 20.

Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Cocaine is a strong central nervous system stimulant, which can induce drug addiction. Previous studies have reported that cocaine-induced autophagy is involved in neuroinflammation and cell death. However, the role of autophagy in psychomotor sensitivity to cocaine has not been explored. Read More

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http://dx.doi.org/10.1111/adb.12736DOI Listing
February 2019
1 Read

The role of 6-acetylmorphine in heroin-induced reward and locomotor sensitization in mice.

Addict Biol 2019 Feb 20. Epub 2019 Feb 20.

Section for Drug Abuse Research, Department of Forensic Sciences, Oslo University Hospital, Oslo, Norway.

We have previously demonstrated that heroin's first metabolite, 6-acetylmorphine (6-AM), is an important mediator of heroin's acute effects. However, the significance of 6-AM to the rewarding properties of heroin still remains unknown. The present study therefore aimed to examine the contribution of 6-AM to heroin-induced reward and locomotor sensitization. Read More

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http://dx.doi.org/10.1111/adb.12727DOI Listing
February 2019
2 Reads

Role of glucocorticoids on noradrenergic and dopaminergic neurotransmission within the basolateral amygdala and dentate gyrus during morphine withdrawal place aversion.

Addict Biol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pharmacology, University of Murcia, Murcia, Spain.

Aversive memories related to drug withdrawal can generate a motivational state leading to compulsive drug taking. However, the mechanisms underlying the generation of these withdrawal memories remain unclear. Limbic structures, such as the basolateral amygdala (BLA) and the dentate gyrus (DG) of the hippocampus, play a crucial role in the negative affective component of morphine withdrawal. Read More

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http://dx.doi.org/10.1111/adb.12728DOI Listing
February 2019
1 Read

The influence of sex and estrous cyclicity on cocaine and remifentanil demand in rats.

Addict Biol 2019 Feb 19. Epub 2019 Feb 19.

Department of Psychology, University of Kentucky, Lexington, KY, USA.

The application of behavioral economic demand theory in addiction science has proved useful for evaluating individual characteristics underlying abuse liability. Two factors that have received comparably little attention within this literature are sex and gonadal hormones. We determined cocaine and remifentanil demand in male and female rats using a within-session procedure. Read More

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http://dx.doi.org/10.1111/adb.12716DOI Listing
February 2019
3 Reads

Adolescence versus adulthood: Differences in basal mesolimbic and nigrostriatal dopamine transmission and response to drugs of abuse.

Addict Biol 2019 Feb 18. Epub 2019 Feb 18.

National Research Council of Italy, Institute of Neuroscience, Italy.

Epidemiological studies have shown that people who begin experimenting drugs of abuse during adolescence are more likely to develop substance use disorders, and the earliest is the beginning of their use, the greatest is the likelihood to become dependent. Understanding the neurobiological changes increasing adolescent vulnerability to drug use is becoming imperative. Although all neurotransmitter systems undergo relevant developmental changes, dopamine system is of particular interest, given its role in a variety of functions related to reward, motivation, and decision making. Read More

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http://dx.doi.org/10.1111/adb.12721DOI Listing
February 2019
1 Read

Neuroimmune and epigenetic involvement in adolescent binge ethanol-induced loss of basal forebrain cholinergic neurons: Restoration with voluntary exercise.

Addict Biol 2019 Feb 18. Epub 2019 Feb 18.

Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Binge drinking and alcohol abuse are common during adolescence and cause lasting pathology. Preclinical rodent studies using the adolescent intermittent ethanol (AIE; 5.0 g/kg, i. Read More

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http://dx.doi.org/10.1111/adb.12731DOI Listing
February 2019
1 Read

Pharmacological targeting of the GABA receptor alters Drosophila's behavioural responses to alcohol.

Addict Biol 2019 Feb 13. Epub 2019 Feb 13.

Medicines Research Group, University of East London, London, UK.

When exposed to ethanol, Drosophila melanogaster display a variety of addiction-like behaviours similar to those observed in mammals. Sensitivity to ethanol can be quantified by measuring the time at which 50% of the flies are sedated by ethanol exposure (ST50); an increase of ST50 following multiple ethanol exposures is widely interpreted as development of tolerance to ethanol. Sensitivity and tolerance to ethanol were measured after administration of the gamma-aminobutyric acid receptor B (GABA ) agonist (SKF 97541) and antagonist (CGP 54626), when compared with flies treated with ethanol alone. Read More

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http://dx.doi.org/10.1111/adb.12725DOI Listing
February 2019
5 Reads

Ultrahigh-resolution MRI reveals structural brain differences in serotonin transporter knockout rats after sucrose and cocaine self-administration.

Addict Biol 2019 Feb 12. Epub 2019 Feb 12.

Department of Cognitive Neuroscience, Centre for Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboudumc, Nijmegen, The Netherlands.

Excessive use of cocaine is known to induce changes in brain white and gray matter. It is unknown whether the extent of these changes is related to individual differences in vulnerability to cocaine addiction. One factor increasing vulnerability involves reduced expression of the serotonin transporter (5-HTT). Read More

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http://dx.doi.org/10.1111/adb.12722DOI Listing
February 2019
8 Reads

Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone.

Addict Biol 2019 Feb 12. Epub 2019 Feb 12.

Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.

During the first weeks of abstinence, alcohol craving in patients may increase or "incubate." We hypothesize that Naltrexone (NTX) blocks this incubation effect. Here, we compared NTX effects on neural alcohol cue reactivity (CR) over the first weeks of abstinence and on long-term clinical outcomes to standard treatment. Read More

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http://dx.doi.org/10.1111/adb.12717DOI Listing
February 2019
2 Reads

Demonstration of critical role of GRIN3A in nicotine dependence through both genetic association and molecular functional studies.

Addict Biol 2019 Feb 11. Epub 2019 Feb 11.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine, China.

Nicotine dependence (ND) is a chronic disease with catastrophic effects on individual and public health. The glutamate receptor subunit gene, ionotropic N-methyl-d-aspartate 3A (GRIN3A), encodes a crucial subunit of N-methyl-d-aspartate receptors (NMDARs), which play an essential role in synaptic plasticity in the brain. Although various variants of GRIN3A have been associated with ND in European-American and African-American samples, no study has been reported for the association between GRIN3A and ND in Chinese Han population. Read More

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http://dx.doi.org/10.1111/adb.12718DOI Listing
February 2019
1 Read

Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice.

Addict Biol 2019 Feb 7. Epub 2019 Feb 7.

Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

In drug addiction, environmental stimuli previously associated with cocaine use readily elicit cocaine-associated memories, which persist long after abstinence and trigger cocaine craving and consumption. Although previous studies suggest that the medial prefrontal cortex (mPFC) is involved in the expression of cocaine-addictive behaviors, it remains unclear whether excitatory and inhibitory neurons in the mPFC are causally related to the formation and retrieval of cocaine-associated memories. To address this issue, we used the designer receptors exclusively activated by designer drugs (DREADD) technology combined with a cocaine-induced conditioned place preference (CPP) paradigm. Read More

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http://dx.doi.org/10.1111/adb.12723DOI Listing
February 2019
2 Reads

N-acetylcysteine yields sex-specific efficacy for cue-induced reinstatement of nicotine seeking.

Addict Biol 2019 Feb 7. Epub 2019 Feb 7.

Department of Psychology, Arizona State University, Tempe, Arizona.

Women report greater craving during certain phases of the menstrual cycle. As well, research indicates that pharmacotherapies for smoking may be less efficacious in women compared with men, which may be due to interactions with natural fluctuations in ovarian hormone levels. N-Acetylcysteine (NAC) is a glutamatergic compound that has shown some efficacy in treating substance use disorders and aids in the prevention of relapse. Read More

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http://doi.wiley.com/10.1111/adb.12711
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http://dx.doi.org/10.1111/adb.12711DOI Listing
February 2019
13 Reads

Cocaine'omics: Genome-wide and transcriptome-wide analyses provide biological insight into cocaine use and dependence.

Addict Biol 2019 Feb 8. Epub 2019 Feb 8.

Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado.

We investigated the genetic and molecular architecture of cocaine dependence (CD) and cocaine use by integrating genome-/transcriptome-wide analyses. To prioritize candidates for follow-up investigation, we also sought to translate gene expression findings across species. Using data from the largest genome-wide association study (GWAS) of CD to date (n = 3176, 74% with CD), we assessed genomic heritability, gene-based associations, and tissue enrichment. Read More

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http://dx.doi.org/10.1111/adb.12719DOI Listing
February 2019
1 Read

The role of DNA methyltransferase activity in cocaine treatment and withdrawal in the nucleus accumbens of mice.

Addict Biol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pharmacology, Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia.

An increasing number of reports have provided crucial evidence that epigenetic modifications, such as DNA methylation, may be involved in initiating and establishing psychostimulant-induced stable changes at the cellular level by coordinating the expression of gene networks, which then manifests as long-term behavioral changes. In this study, we evaluated the enzyme activity of DNA methyltransferases (DNMTs) after cocaine treatment and during withdrawal. Furthermore, we studied how genetic or pharmacological inhibition of DNMTs in mouse nucleus accumbens (NAc) affects the induction and expression of cocaine-induced behavioral sensitization. Read More

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http://dx.doi.org/10.1111/adb.12720DOI Listing
February 2019

Differential gene expression and stereological analyses of the cerebellum following methamphetamine exposure.

Addict Biol 2019 Feb 4. Epub 2019 Feb 4.

Cell Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Iran.

Methamphetamine (METH) is a highly addictive psychostimulant that profoundly aimed at monoaminergic systems in the brain. Despite the leading role of cerebellum in sensorimotor control as well as augmented locomotor activity under the influence of METH, there are few studies examining the effect of METH administration on gene expression profiling and structural consequences in the cerebellar region. Thus, we sought to explore the effects of METH on the cerebellum, from gene expression changes to structural alterations. Read More

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http://dx.doi.org/10.1111/adb.12707DOI Listing
February 2019
1 Read

Reconsolidation impairment of reward memory by stimulating stress response.

Addict Biol 2019 Jan 22. Epub 2019 Jan 22.

Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany.

Research in memory reconsolidation has raised hope for new treatment options of persistent psychiatric disorders like substance dependence and post-traumatic stress disorder (PTSD). While animal research showed successful memory modification by interfering with reconsolidation, human research requires less invasive techniques. In our pilot study, we aimed to reduce appetitive memory reconsolidation of a newly acquired reward memory by exerting a stressor. Read More

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http://doi.wiley.com/10.1111/adb.12712
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http://dx.doi.org/10.1111/adb.12712DOI Listing
January 2019
18 Reads

The role of matrix metalloproteinase-9 in negative reinforcement learning and plasticity in alcohol dependence.

Addict Biol 2019 Jan 16. Epub 2019 Jan 16.

Laboratory of Alcoholism and Addictions Neuroscience, Department of Psychology, Alcohol and Drug Abuse Research Program, Translational Addictions Research Center, Washington State University, Pullman, Washington, USA.

A role for matrix metalloproteinases (MMPs) in plasticity-dependent learning has been established. MMPs degrade the extracellular matrix (ECM) when synaptic reorganization is warranted. Previously, we showed that escalation of alcohol self-administration is a learned plasticity-dependent process that requires an intact MMP system. Read More

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http://dx.doi.org/10.1111/adb.12715DOI Listing
January 2019
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The role of the paraventricular nucleus of the thalamus in the augmentation of heroin seeking induced by chronic food restriction.

Addict Biol 2019 Jan 9. Epub 2019 Jan 9.

Department of Psychology, Center for Studies in Behavioral Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Canada.

Drug addiction is a chronic disorder that is characterized by compulsive drug seeking and involves cycling between periods of compulsive drug use, abstinence, and relapse. In both human addicts and animal models of addiction, chronic food restriction has been shown to increase rates of relapse. Previously, our laboratory has demonstrated a robust increase in drug seeking following a period of withdrawal in chronically food-restricted rats compared with sated rats. Read More

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http://doi.wiley.com/10.1111/adb.12708
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http://dx.doi.org/10.1111/adb.12708DOI Listing
January 2019
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Central nucleus of the amygdala as a common substrate of the incubation of drug and natural reinforcer seeking.

Addict Biol 2019 Jan 8. Epub 2019 Jan 8.

Department of Psychobiology, School of Psychology, UNED, Madrid, Spain.

Relapse into drug use is a major problem faced by recovering addicts. In humans, an intensification of the desire for the drug induced by environmental cues-incubation of drug craving-has been observed. In rodents, this phenomenon has been modeled by studying drug seeking under extinction after different times of drug withdrawal (or using a natural reinforcer). Read More

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http://dx.doi.org/10.1111/adb.12706DOI Listing
January 2019
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Support vector machine-based multivariate pattern classification of methamphetamine dependence using arterial spin labeling.

Addict Biol 2019 Jan 9. Epub 2019 Jan 9.

Laboratory of Behavioral Neuroscience, Ningbo Addiction Research and Treatment Center, Ningbo, China.

Arterial spin labeling (ASL) magnetic resonance imaging has been widely applied to identify cerebral blood flow (CBF) abnormalities in a number of brain disorders. To evaluate its significance in detecting methamphetamine (MA) dependence, this study used a multivariate pattern classification algorithm, ie, a support vector machine (SVM), to construct classifiers for discriminating MA-dependent subjects from normal controls. Forty-five MA-dependent subjects, 45 normal controls, and 36 heroin-dependent subjects were enrolled. Read More

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http://doi.wiley.com/10.1111/adb.12705
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http://dx.doi.org/10.1111/adb.12705DOI Listing
January 2019
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Cue-elicited craving-related lentiform activation during gaming deprivation is associated with the emergence of Internet gaming disorder.

Addict Biol 2019 Jan 6. Epub 2019 Jan 6.

Department of Psychiatry, Department of Neurobiology, and Child Study Center, Yale University School of Medicine, New Haven, Connecticut.

Internet gaming disorder (IGD) is associated with negative health measures. However, little is known regarding the brain mechanisms or cognitive factors that may predict transitions from regular game use (RGU) to IGD. Such knowledge may help identify individuals who are particularly vulnerable to IGD and aid in prevention efforts. Read More

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http://doi.wiley.com/10.1111/adb.12713
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http://dx.doi.org/10.1111/adb.12713DOI Listing
January 2019
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Polysubstance addiction vulnerability in mental illness: Concurrent alcohol and nicotine self-administration in the neurodevelopmental hippocampal lesion rat model of schizophrenia.

Addict Biol 2018 Dec 28. Epub 2018 Dec 28.

Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN.

Multiple addictions frequently occur in patients with mental illness. However, basic research on the brain-based linkages between these comorbidities is extremely limited. Toward characterizing the first animal modeling of polysubstance use and addiction vulnerability in schizophrenia, adolescent rats with neonatal ventral hippocampal lesions (NVHLs) and controls had 19 weekdays of 1 hour/day free access to alcohol/sucrose solutions (fading from 10% sucrose to 10% alcohol/2% sucrose on day 10) during postnatal days (PD 35-60). Read More

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http://dx.doi.org/10.1111/adb.12704DOI Listing
December 2018
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Subthalamic nucleus mediates the modulation on cocaine self-administration induced by ultrasonic vocalization playback in rats.

Addict Biol 2018 Dec 28. Epub 2018 Dec 28.

Institut de Neurosciences de la Timone, UMR 7289 CNRS and Aix-Marseille Université, Marseille, France.

Drug intake is known to be under the influence of social context. We have recently shown that presence of a peer influences drug intake in both rats and humans. Whether or not social acoustic communications between the peers play a role during cocaine or sucrose self-administration (SA) was investigated here using playback of ultrasonic vocalizations (USVs) at 50 and 22 kHz, conveying, respectively, positive and negative internal affective states in adult rats. Read More

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http://dx.doi.org/10.1111/adb.12710DOI Listing
December 2018
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Oxytocin inhibits methamphetamine-associated learning and memory alterations by regulating DNA methylation at the Synaptophysin promoter.

Addict Biol 2018 Dec 25. Epub 2018 Dec 25.

Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China.

Methamphetamine (METH) causes memory changes, but the underlying mechanisms are poorly understood. Epigenetic mechanisms, including DNA methylation, can potentially cause synaptic changes in the brain. Oxytocin (OT) plays a central role in learning and memory, but little is known of the impact of OT on METH-associated memory changes. Read More

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http://doi.wiley.com/10.1111/adb.12697
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http://dx.doi.org/10.1111/adb.12697DOI Listing
December 2018
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Brain GABA levels are reduced in alcoholic liver disease: A proton magnetic resonance spectroscopy study.

Addict Biol 2018 Dec 18. Epub 2018 Dec 18.

NHMRC Centre of Research Excellence in Mental Health and Substance Use, Central Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.

Background And Aims: Baclofen, a selective γ-aminobutyric acid (GABA) receptor agonist, has emerged as a potential treatment for alcohol use disorder with much unexplained variation in response to treatment efficacy and dose regimen. Several positive studies include patients with alcoholic liver disease (ALD) and/or history of heavy drinking. The aim of this paper was to examine the association of cortical GABA+ concentration with severity of liver disease (including markers of liver injury) and other clinical characteristics in alcohol patients. Read More

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http://dx.doi.org/10.1111/adb.12702DOI Listing
December 2018
2 Reads