DRD2 promoter methylation and measures of alcohol reward: functional activation of reward circuits and clinical severity.
- L Cinnamon Bidwell,
- Hollis C Karoly,
- Rachel E Thayer,
- Eric D Claus,
- Angela D Bryan,
- Barbara J Weiland,
- Sophie YorkWilliams,
- Kent E Hutchison
Addict Biol 2018 Feb 21. Epub 2018 Feb 21.
Institute of Cognitive Science, University of Colorado Boulder, Boulder, CO, USA.
Studies have identified strong associations between D2 receptor binding potential and neural responses to rewarding stimuli and substance use. Thus, D2 receptor perturbations are central to theoretical models of the pathophysiology of substance dependence, and epigenetic changes may represent one of the fundamental molecular mechanisms impacting the effects of alcohol exposure on the brain. We hypothesized that epigenetic alterations in the promoter region of the dopamine D2 receptor (DRD2) gene would be associated with cue-elicited activation of neural reward regions, as well as severity of alcohol use behavior. Read More