70,450 results match your criteria Addiction Abingdon England[Journal]


A Different Kind of Relapse: Ethanol as an Additive in Chemotherapy Formulations.

Oncol Res Treat 2019 Apr 17:1-4. Epub 2019 Apr 17.

University Cancer Center Leipzig (UCCL), University Hospital Leipzig, Leipzig, Germany.

Some chemotherapy formulations contain ethanol as a solvent which can become relevant for medical and nonmedical reasons. Only a few studies have tried to quantify the effects of ethanol in chemotherapy preparations. Furthermore, the alcohol amount highly depends on the specific formulation, with some variation among different manufacturers. Read More

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http://dx.doi.org/10.1159/000497216DOI Listing

Oral Ketamine for Depression: A Systematic Review.

J Clin Psychiatry 2019 Apr 16;80(3). Epub 2019 Apr 16.

Mood Disorder Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Objective: Intravenous (IV) ketamine has rapid and robust antidepressant effects; however, poor accessibility of the IV route often limits its use. Numerous alternative routes of administration are being investigated. Oral ketamine is particularly appealing for its ease of use with the potential for high accessibility. Read More

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http://dx.doi.org/10.4088/JCP.18r12475DOI Listing
April 2019
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Modulation of 'Protective' Nicotine Perception and Use Profile by Flavorants: Preliminary Findings in E-Cigarettes.

Nicotine Tob Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT.

Introduction: Characterizing flavors are widely available in e-cigarettes and motivate initiation and continued use. Flavors may enhance appeal and facilitate development of addiction to tobacco products through modulation of tobacco products' reinforcing or aversive actions. Palatable flavors (e. Read More

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http://dx.doi.org/10.1093/ntr/ntz057DOI Listing

Brief interventions for problem gambling: A meta-analysis.

PLoS One 2019 17;14(4):e0214502. Epub 2019 Apr 17.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada.

Background: Brief interventions have been increasingly investigated to promote early intervention in gambling problems; an accurate estimate of the impact of these interventions is required to justify their widespread implementation. The goal of the current investigation was to evaluate the efficacy of in-person brief interventions for reducing gambling behaviour and/or problems, by quantifying the aggregate effect size associated with these interventions in the published literature to date.

Methods: Randomized controlled trials including the following design features were identified via systematic review: an adult sample experiencing problems associated with gambling; an in-person individual psychosocial intervention of brief duration (≤3 sessions); a control/comparison group; and an outcome related to gambling behaviour and/or problems. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214502PLOS
April 2019
1 Read

Craving for heroin: difference between methadone maintenance therapy patients with and without ADHD.

Trends Psychiatry Psychother 2019 Jan-Mar;41(1):83-86. Epub 2019 Apr 11.

Dipartimento Salute Mentale, ASL CN1, Saluzzo, CN, Italy.

Introduction: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder persisting in adulthood in 40-60% of cases. Clinical and neuroimaging studies suggest that patients affected by both drug addiction and ADHD show higher rates of craving for drug than patients without ADHD. We designed a pilot open-label study to investigate the effects of ADHD on craving for heroin in methadone maintenance therapy patients. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/2237-6089-2017-0159DOI Listing
April 2019
1 Read

A critical literature review on emotional intelligence in addiction.

Trends Psychiatry Psychother 2019 Jan-Mar;41(1):87-93. Epub 2019 Apr 1.

Departamento de Psiquiatria, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.

Introduction: Emotional intelligence (EI) has been defined as the ability to perceive, understand, use and manage emotions. Studying EI could potentially be useful in understanding addictive behaviors as well as for designing and planning interventions.

Objectives: To conduct a critical review on EI impairment in addiction disorders. Read More

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http://dx.doi.org/10.1590/2237-6089-2018-0002DOI Listing

Do drinking problems in the past affect current consumption?

Cad Saude Publica 2019 8;35(4):e00025618. Epub 2019 Apr 8.

Centre for Business and Economics Research, Coimbra, Portugal.

Harmful use of alcohol ranks among the top five risk factors for disease, disability and death worldwide. However, not all individuals who consume alcohol throughout life are addicted and our premise is that addiction implies a chain of consumption that produces harmful effects. The objective of this study was to evaluate whether self-assessed past drinking problems - our measure of harmful alcohol consumption - affect the current alcohol consumption patterns. Read More

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http://dx.doi.org/10.1590/0102-311X00025618DOI Listing

A retrospective cohort study comparing non-fatal self-harm emergency department visits between Canadian veterans living in Ontario and matched civilians.

Int Rev Psychiatry 2019 Apr 17:1-9. Epub 2019 Apr 17.

d IC/ES , Toronto , Canada.

This was a retrospective cohort study linking provincial administrative databases to compare rates of non-fatal self-harm between CAF and RCMP veterans living in Ontario and age-matched civilians. This study included male veterans who registered for provincial health insurance between 2002 and 2013. A civilian comparator group was matched 4:1 on age and sex. Read More

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http://dx.doi.org/10.1080/09540261.2019.1580685DOI Listing

Metabolomics reveals tepotinib-related mitochondrial dysfunction in MET activating mutations-driven models.

FEBS J 2019 Apr 16. Epub 2019 Apr 16.

Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland.

Genetic aberrations in the hepatocyte growth factor receptor tyrosine kinase MET induce oncogenic addiction in various types of human cancers, advocating MET as a viable anticancer target. Here, we report that MET signaling plays an important role in conferring a unique metabolic phenotype to cellular models expressing MET-activating mutated variants that are either sensitive or resistant towards MET small molecule inhibitors. MET phosphorylation downregulated by the specific MET inhibitor tepotinib resulted in markedly decreased viability and increased apoptosis in tepotinib-sensitive cells. Read More

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http://dx.doi.org/10.1111/febs.14852DOI Listing

Initiation Sequence of E-Cigarette and Cigarette Smoking among US Adolescents: A National Study.

Am J Addict 2019 Apr 16. Epub 2019 Apr 16.

Center for the Study of Drugs, Alcohol, Smoking, and Health, Department of Health Behavior and Biological Sciences, School of Nursing, University of Michigan, Ann Arbor, Michigan.

Background And Objectives: The primary objectives were to: (1) examine the initiation sequence of e-cigarette use and cigarette smoking; (2) assess other substance use as a function of the initiation sequence of e-cigarettes and cigarettes; and (3) investigate the role of early e-cigarette initiation among US secondary school students.

Methods: Data were collected via self-administered questionnaires from independent 2015 and 2016 nationally representative cross-sectional samples of 8th grade, 10th grade, and 12th grade students (N = 36 410).

Results: The lifetime initiation sequence included: (1) e-cigarette use before cigarette smoking (1. Read More

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http://dx.doi.org/10.1111/ajad.12886DOI Listing

Separation anxiety and gender variance in a community sample of children.

Eur Child Adolesc Psychiatry 2019 Apr 16. Epub 2019 Apr 16.

Department of Psychology, University of Toronto Mississauga, Mississauga, ON, L5L 1C6, Canada.

In clinical child and retrospective adult samples, childhood gender variance (GV; i.e., cross-gender behaviour) has been associated with separation anxiety (SA; i. Read More

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http://link.springer.com/10.1007/s00787-019-01319-3
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http://dx.doi.org/10.1007/s00787-019-01319-3DOI Listing
April 2019
1 Read

Physical activity and fitness among pediatric cancer survivors: a meta-analysis of observational studies.

Support Care Cancer 2019 Apr 16. Epub 2019 Apr 16.

Division of Pediatric Hematology and Oncology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.

Purpose: The number of pediatric cancer survivors has increased dramatically over recent decades. Prior studies involving pediatric cancer survivors have reported reduced physical activity and fitness levels. Thus, the aim of this meta-analysis was to synthesize previous findings on physical activity and fitness levels of pediatric cancer survivors, who had completed cancer treatment and are in complete remission compared with age-matched, non-athletic healthy controls with no history of cancer diagnosis. Read More

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http://dx.doi.org/10.1007/s00520-019-04788-zDOI Listing

Possible Role of Cyclic AMP Response Element Binding/Brain-Derived Neurotrophic Factor Signaling Pathway in Mediating the Pharmacological Effects of Duloxetine against Methamphetamine Use-Induced Cognitive Impairment and Withdrawal-Induced Anxiety and Depression in Rats.

Adv Biomed Res 2019 21;8:11. Epub 2019 Feb 21.

Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: Duloxetine is used for treating depression and anxiety. The current study evaluated the effects of duloxetine against methamphetamine withdrawal-induced anxiety, depression, and motor disturbances and methamphetamine use-induced cognitive impairments.

Materials And Methods: Ninety-six adult male rats were used for two independent experiments. Read More

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http://dx.doi.org/10.4103/abr.abr_34_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425746PMC
February 2019

Mental Healthcare Act, 2017, and addiction treatment: Potential pitfalls and trepidations.

Indian J Psychiatry 2019 Mar-Apr;61(2):208-212

Department of Psychiatry, National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India.

The Mental Healthcare Act (MHCA), 2017, is enacted with an aim to promote and protect the rights of and improve the care and treatment for people affected by mental illness in India. The Act purportedly includes substance use disorder (SUD) specifically in the definition of mental illness itself. However, some of the phrases used in the definition such as "abuse" are not clear, as the current classificatory systems of mental illnesses do not have any diagnostic category termed "abuse. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_463_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425793PMC

Case vignette-based evaluation of psychiatric blended training program of primary care doctors.

Indian J Psychiatry 2019 Mar-Apr;61(2):204-207

Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Introduction: The need to integrate psychiatry in primary care is increasingly recognized as the favorable strategy worldwide. The contribution of primary care doctors (PCDs) is extremely important toward it. However, majority PCDs find it difficult to diagnose and treat common psychiatric disorders. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_250_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425787PMC

Perceived parental style, cognitive style, and resilience in females with dissociative disorder in India.

Indian J Psychiatry 2019 Mar-Apr;61(2):177-183

Department of Psychiatry and Drug De-addiction, Centre of Excellence in Mental Health, Post Graduate Institute of Medical Education and Research-Dr Ram Manohar Lohia Hospital, New Delhi, India.

Background: Dissociative disorders are theorized to be caused by extremely stressful situations, including abuse, kidnapping, incest, rape, and other threats of death. Such childhood experiences alter one's cognitive style as well as one's ability to deal with adverse situations. It is important to understand how cognitive style influences the relationship between parental style and resilience to help in the management. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_404_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425806PMC

Intrinsic insular-frontal networks predict future nicotine dependence severity.

J Neurosci 2019 Apr 16. Epub 2019 Apr 16.

Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, 251 Bayview Blvd, Baltimore, MD, 21224

Although 60% of the US population have tried smoking cigarettes, only 16% smoke regularly. Identifying this susceptible subset of the population before the onset of nicotine dependence may encourage targeted early interventions to prevent regular smoking and/or minimize severity. While prospective neuroimaging in human populations can be challenging, preclinical neuroimaging models prior to chronic nicotine administration can help develop translational biomarkers of disease risk. Read More

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http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.0140-1
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http://dx.doi.org/10.1523/JNEUROSCI.0140-19.2019DOI Listing
April 2019
1 Read

Case Report: Unprovoked venous thromboembolism in a young adult male.

F1000Res 2019 14;8:182. Epub 2019 Feb 14.

Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.

A 24-year-old male was presented to us with sudden onset of chest pain and dyspnea for the past one hour. There was no history of calf pain, trauma, surgery, prolonged immobilization, long-haul air travel, bleeding diathesis or any other co-morbidity. The patient denied any addiction history. Read More

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https://f1000research.com/articles/8-182/v1
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http://dx.doi.org/10.12688/f1000research.18202.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446494PMC
February 2019
2 Reads

Flexible assertive community treatment for individuals with a mild intellectual disability or borderline intellectual functioning: results of a longitudinal study in the Netherlands.

J Intellect Disabil Res 2019 Apr 16. Epub 2019 Apr 16.

Behavioural Science Institute (BSI), Radboud University, Nijmegen, the Netherlands & Trajectum, Zwolle, the Netherlands.

Background: Assertive community treatment (ACT) and Flexible assertive community treatment (FACT) are organisation models for intensive assertive outreach that were originally developed for individuals with severe mental illness. The models are increasingly applied to people with mild intellectual disability (MID) or borderline intellectual functioning (BIF) and challenging behaviour or mental illness. Research on these types of care for this population is limited. Read More

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http://dx.doi.org/10.1111/jir.12619DOI Listing

An experimental study on spontaneous recovery of conditioned reward expectancies and instrumental responding in humans.

Behav Res Ther 2019 Mar 21;118:54-64. Epub 2019 Mar 21.

Sussex Addiction Research and Intervention Centre, School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QH, UK.

The aim of the present study was to investigate spontaneous recovery of reward-expectancies and a reward-associated response in humans and to assess individual factors affecting spontaneous recovery. We therefore implemented an experimental procedure comprising three separate test-sessions. In the first test-session, participants underwent instrumental discrimination training to acquire a conditioned reward-associated response, in the second test-session, memory of this response was tested followed by extinction training. Read More

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http://dx.doi.org/10.1016/j.brat.2019.03.010DOI Listing

Increased [³H]quisqualic acid binding density in the dorsal striatum and anterior insula of alcoholics: A post-mortem whole-hemisphere autoradiography study.

Psychiatry Res Neuroimaging 2019 Apr 8;287:63-69. Epub 2019 Apr 8.

Department of Psychiatry, Kuopio University Hospital, P.O. Box 100, FI-70029 Kuopio, Finland.

The function of group I metabotropic glutamate receptors mGluR1 and mGluR5 is involved in the hyperglutamatergic state caused by chronic alcohol. Preclinical studies suggest that group I mGluR modulation could serve as a novel treatment of alcoholism. Considering the wide role of glutamatergic neurochemistry in addiction, group I mGluR binding was studied in brain areas involved in decision-making, learning and memory. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2019.04.002DOI Listing

The effect of N-acetylcysteine and working memory training on neural mechanisms of working memory and cue reactivity in regular cocaine users.

Psychiatry Res Neuroimaging 2019 Apr 5;287:56-59. Epub 2019 Apr 5.

Addiction, Development, and Psychopathology (ADAPT) lab, Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands.

The current study investigated the combined effects of N-acetylcysteine and working memory (WM) training on behavioral and neural mechanisms of cue reactivity and WM in cocaine users in a randomized, double-blind design. Twenty-four of 38 cocaine-using men completed a 25-day treatment with either 2400 mg/day NAC or placebo. Both groups performed WM-training. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2019.03.011DOI Listing

Measurement of substance-free reinforcement in addiction: A systematic review.

Clin Psychol Rev 2019 Apr 5;70:79-90. Epub 2019 Apr 5.

Department of Psychology, University of Memphis, 400 Innovation Dr., Memphis, TN 38152, United States. Electronic address:

A robust body of theoretical and experimental work highlights the influence of alternative, substance-free rewards on decisions to use alcohol and other drugs. However, translational applications have been limited in part by the lack of consensus on how to measure substance-free reinforcement in applied and clinical settings. The current study summarizes extant research utilizing self-report reinforcement or reward methodologies, and critically reviews the psychometric properties of the available measures. Read More

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http://dx.doi.org/10.1016/j.cpr.2019.04.003DOI Listing

Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala.

PLoS Biol 2019 Apr 16;17(4):e2006421. Epub 2019 Apr 16.

Neurobiology of Addiction Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States of America.

Oxytocin administration has been reported to decrease consumption, withdrawal, and drug-seeking associated with several drugs of abuse and thus represents a promising pharmacological approach to treat drug addiction. We used an established rat model of alcohol dependence to investigate oxytocin's effects on dependence-induced alcohol drinking, enhanced motivation for alcohol, and altered GABAergic transmission in the central nucleus of the amygdala (CeA). Intraperitoneal oxytocin administration blocked escalated alcohol drinking and the enhanced motivation for alcohol in alcohol-dependent but not nondependent rats. Read More

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http://dx.doi.org/10.1371/journal.pbio.2006421DOI Listing

Mortality in older adults with frequent alcohol consumption and use of drugs with addiction potential - The Nord Trøndelag Health Study 2006-2008 (HUNT3), Norway, a population-based study.

PLoS One 2019 16;14(4):e0214813. Epub 2019 Apr 16.

Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.

Background: The aim of this study was to investigate whether frequent drinking, use of drugs with addiction potential and the possible combination of frequent drinking and use of prescribed drugs with addiction potential were associated with all-cause mortality in older adults.

Methods: We used data from the Nord-Trøndelag Health Study (HUNT3 2006-08), a population-based study in Norway. A total of 11,545 (6,084 women) individuals 65 years and older at baseline participated. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214813PLOS

Violence risk and mental disorders (VIORMED-2): A prospective multicenter study in Italy.

PLoS One 2019 16;14(4):e0214924. Epub 2019 Apr 16.

Unit of Epidemiological and Evaluation Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.

Background: The management of mentally ill offenders in the community is one of the great challenges imposed on community psychiatry.

Aim: The aim of this study was to analyze the association between sociodemographic, clinical, and psychosocial factors and violent behavior in a sample of outpatients with severe mental disorders.

Method: This was a prospective cohort study with a baseline cross-sectional design used to provide a detailed analysis of patients' profiles, followed by a longitudinal design to measure aggressive and violent behavior during a 1-year follow-up. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214924PLOS
April 2019
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Making Amends for the Opioid Epidemic.

JAMA 2019 Apr;321(15):1446-1447

Medical director of the Institutes for Behavior Resources, Inc, an addiction treatment program in Baltimore, Maryland.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2019.3505DOI Listing
April 2019
1 Read

Designing a Chatbot for a Brief Motivational Interview on Stress Management: Qualitative Case Study.

J Med Internet Res 2019 Apr 16;21(4):e12231. Epub 2019 Apr 16.

Human Centered Computing Lab., Seoul National University, Seoul, Republic of Korea.

Background: In addition to addiction and substance abuse, motivational interviewing (MI) is increasingly being integrated in treating other clinical issues such as mental health problems. Most of the many technological adaptations of MI, however, have focused on delivering the action-oriented treatment, leaving its relational component unexplored or vaguely described. This study intended to design a conversational sequence that considers both technical and relational components of MI for a mental health concern. Read More

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http://dx.doi.org/10.2196/12231DOI Listing

Time is overestimated in obesity: A cohort study.

J Health Psychol 2019 Apr 16:1359105319842937. Epub 2019 Apr 16.

4 University of Melbourne, Australia.

Food addiction and high impulsivity are common traits in obesity. In accordance with the evidence that time is overestimated in patients with a history of impulsivity and/or drug addiction, we tested the hypothesis that duration is overestimated in obesity. A total of 92 obese participants and 182 healthy controls completed a timing task of visual stimuli. Read More

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http://dx.doi.org/10.1177/1359105319842937DOI Listing

Overexpression of miR-9 in the nucleus accumbens increases oxycodone self-administration.

Int J Neuropsychopharmacol 2019 Apr 16. Epub 2019 Apr 16.

Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, U.S.A.

Background: There is an urgent need to identify factors that increase vulnerability to opioid addiction to help stem the opioid epidemic and develop more efficient pharmacotherapeutics. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at a posttranscriptional level and have been implicated in chronic drug-taking in humans and in rodent models. Recent evidence has shown that chronic opioid treatment regulates the microRNA miR-9. Read More

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https://academic.oup.com/ijnp/advance-article/doi/10.1093/ij
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http://dx.doi.org/10.1093/ijnp/pyz015DOI Listing
April 2019
1 Read

Environmental and familial factors in drug use among commercial drivers in suburban public transport.

Int J Crit Illn Inj Sci 2019 Jan-Mar;9(1):25-28

Department of Safety Promotion and Injury Prevention Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: A study was conducted in 2013 on the lack of accurate statistics on the environmental and family factors behind the use of drugs by drivers of public transport.

Materials And Methods: Overall, 1176 drivers of buses, mini-buses, vans, all kinds of trucks, and cars were randomly selected proportionately according to the type of vehicles. The capture-recapture sampling method was used to determine the prevalence rate of drug use among commercial drivers. Read More

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http://dx.doi.org/10.4103/IJCIIS.IJCIIS_38_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423924PMC

Lead Toxicity due to Ingestion of Lead-Contaminated Opium in a Patient Presenting with Motor Neuropathy and Upper Limb : A case report.

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e529-e532. Epub 2019 Mar 28.

Department of Clinical Toxicology, Loghman Hakim Hospital, Tehran, Iran.

Opium users may present with central or peripheral nervous system-related symptoms, gastrointestinal complications and anaemia; in such cases, lead poisoning should be suspected and chelation therapy initiated as soon as possible. We report a 64-year-old male patient with a 20-year history of opium addiction who was referred to the Imam Reza Hospital, Birjand, Iran, in 2017 with severe motor neuropathy and in both upper limbs. His primary symptoms were generalised weakness, abdominal and bone pain, constipation and lower limb paraesthesia that had started several months prior. Read More

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http://dx.doi.org/10.18295/squmj.2018.18.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443289PMC
November 2018

Relationships between Internet addiction and clinicodemographic and behavioral factors.

Neuropsychiatr Dis Treat 2019 26;15:739-752. Epub 2019 Mar 26.

Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan,

Backgrounds And Aims: While the Internet became an indispensable component of our contemporary life, public and academic attention is also gathered to its negative impact, namely Internet addiction (IA). Although clinicodemographic and behavioral factors are hypothetically implicated in the mechanism of IA, it still remains largely unknown how such factors are linked to IA severity. Thus, this study sought to examine relationships among IA severity and factors potentially associated with IA in Japanese students in different educational stages. Read More

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http://dx.doi.org/10.2147/NDT.S193357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440534PMC

The Making of an Addiction: Examining Psychological Determinants of Prescription Stimulant Abuse among College Students.

Health Commun 2019 Apr 16:1-9. Epub 2019 Apr 16.

a Department of Communication , Texas A&M University.

Diagnoses of attention-deficit-disorders and stimulant prescriptions to treat these disorders (e.g., Adderall) are on the rise. Read More

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http://dx.doi.org/10.1080/10410236.2019.1598743DOI Listing

Impressions of "Evidence-Based Practice": A Direct-to-Consumer Survey of Caregivers Concerned about Adolescent Substance Use.

Evid Based Pract Child Adolesc Ment Health 2018 1;3(2):70-80. Epub 2018 Mar 1.

Center for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI, USA.

National behavioral health organizations have recently started using direct-to-consumer (DTC) marketing strategies as a means of promoting increased utilization of evidence-based practice (EBP). Such strategies often encourage patients and caregivers to proactively seek out EBP, based on the assumptions that patients and caregivers understand the concept and view it favorably. We conducted a DTC marketing survey of caregivers concerned about their adolescents' substance use in order to explore how these caregivers define, value, and prefer to describe the EBP concept. Read More

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http://dx.doi.org/10.1080/23794925.2018.1429228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457678PMC

Psychiatric comorbidity among first-time and repeat DUI offenders.

Addict Behav 2019 Apr 1;96:1-10. Epub 2019 Apr 1.

Division on Addiction, Cambridge Health Alliance, United States of America; Harvard Medical School, United States of America.

Driving under the influence of alcohol or other substances is a serious public health concern. Previous research has shown that psychiatric comorbidity is more prevalent for repeat offenders than the general population, and that first-time offenders exhibit elevated rates of psychiatric comorbidity, but few studies have directly compared first-time and repeat DUI offenders. The current study compares psychiatric comorbidity among repeat and first-time DUI offenders. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064603183144
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http://dx.doi.org/10.1016/j.addbeh.2019.03.018DOI Listing
April 2019
1 Read

Childhood maltreatment, vulnerability characteristics and adult incident common mental disorders: 3-year longitudinal data among >10,000 adults in the general population.

J Psychiatr Res 2019 Mar 30;113:199-207. Epub 2019 Mar 30.

Department of Psychiatry and Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands.

Childhood maltreatment (CM) is a strong predictor of incident (first-onset and recurrent) mental disorders in adulthood. However, less is known about underlying mechanisms and moderators of these associations. This study examines to what extent vulnerability characteristics (low social support, negative life events, parental psychopathology, neuroticism, history and comorbidity of mental and physical health) contribute to the impact of CM on adult psychopathology. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.03.029DOI Listing

Development of a long-acting Fc-fused cocaine hydrolase with improved yield of protein expression.

Chem Biol Interact 2019 Apr 12. Epub 2019 Apr 12.

Molecular Modeling and Biopharmaceutical Center and Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA. Electronic address:

Human butyrylcholinesterase (BChE) is known as a safe and effective protein for detoxification of organophosphorus (OP) nerve agents. Its rationally designed mutants with considerably improved catalytic activity against cocaine, known as cocaine hydrolases (CocHs), are recognized as the most promising drug candidates for the treatment of cocaine abuse. However, it is a grand challenge to efficiently produce active recombinant BChE and CocHs with a sufficiently long biological half-life. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797193035
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http://dx.doi.org/10.1016/j.cbi.2019.04.012DOI Listing
April 2019
2 Reads

Opioids in the Management of Acute Pediatric Pain: An Update in a Time of Crisis.

Clin J Pain 2019 Apr 12. Epub 2019 Apr 12.

Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD.

Management of acute pain in children is fundamental to our practice. Its myriad benefits include reduced suffering, improved patient satisfaction, more rapid recovery, and a reduced risk of developing postsurgical chronic pain. Although a multimodal analgesic approach is now routinely used, informed and judicious use of opioid receptor agonists remains crucial in this treatment paradigm, as long as the benefits and risks are fully understood. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000709DOI Listing

Causes of death among homeless people: a population-based cross-sectional study of linked hospitalisation and mortality data in England.

Wellcome Open Res 2019 11;4:49. Epub 2019 Mar 11.

Collaborative Centre for Inclusion Health, Institute of Epidemiology & Health Care, University College London, London, NW1 2DA, UK.

: Homelessness has increased by 165% since 2010 in England, with evidence from many settings that those affected experience high levels of mortality. In this paper we examine the contribution of different causes of death to overall mortality in homeless people recently admitted to hospitals in England with specialist integrated homeless health and care (SIHHC) schemes.  : We undertook an analysis of linked hospital admission records and mortality data for people attending any one of 17 SIHHC schemes between 1st November 2013 and 30th November 2016. Read More

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http://dx.doi.org/10.12688/wellcomeopenres.15151.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449792PMC

Identification of a Functional Non-coding Variant in the GABA Receptor α2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research.

Front Genet 2019 29;10:188. Epub 2019 Mar 29.

Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.

GABA type-A (GABA-A) receptors containing the α2 subunit (GABRA2) are expressed in most brain regions and are critical in modulating inhibitory synaptic function. Genetic variation at the locus has been implicated in epilepsy, affective and psychiatric disorders, alcoholism and drug abuse. expression varies as a function of genotype and is modulated by sequence variants in several brain structures and populations, including F2 crosses originating from C57BL/6J (B6J) and the BXD recombinant inbred family derived from B6J and DBA/2J. Read More

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http://dx.doi.org/10.3389/fgene.2019.00188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449455PMC

NOP Receptor Agonist Ro 64-6198 Decreases Escalation of Cocaine Self-Administration in Rats Genetically Selected for Alcohol Preference.

Front Psychiatry 2019 29;10:176. Epub 2019 Mar 29.

Pharmacology Unit, School of Pharmacy, University of Camerino, Camerino, Italy.

Cocaine dependence is a psychiatric condition for which effective medications are still lacking. Published data indicate that an increase in nociceptin/orphanin FQ (N/OFQ) transmission by NOP receptor activation attenuates cocaine-induced place conditioning and the locomotor sensitization effects of cocaine. This suggests that the activation of the N/OFQ receptor (NOP) may attenuate the motivation for psychostimulants. Read More

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http://dx.doi.org/10.3389/fpsyt.2019.00176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450143PMC

Psychometric Evaluation of the Nine-Item Problematic Internet Use Questionnaire (PIUQ-9) in Nine European Samples of Internet Users.

Front Psychiatry 2019 22;10:136. Epub 2019 Mar 22.

Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary.

The nine-item Problematic Internet Use Questionnaire (PIUQ-9) is a brief self-report screening instrument for problematic internet use. The main objective of the present study was to explore the psychometric properties of the PIUQ-9 among nine different language-based samples of European internet users (Italian, German, French, Polish, Turkish, Hungarian, English, and Greek). The total sample comprised 5,593 internet users (38. Read More

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https://www.frontiersin.org/article/10.3389/fpsyt.2019.00136
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http://dx.doi.org/10.3389/fpsyt.2019.00136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448041PMC
March 2019
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Formaldehyde Induces Mesenteric Artery Relaxation via a Sensitive Transient Receptor Potential Ankyrin-1 (TRPA1) and Endothelium-Dependent Mechanism: Potential Role in Postprandial Hyperemia.

Front Physiol 2019 28;10:277. Epub 2019 Mar 28.

Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, United States.

Formaldehyde (FA), the smallest aldehyde, is generated endogenously, and is widespread in the environment in foods, beverages and as a gas phase product of incomplete combustion. The main metabolite of FA, formate, was increased significantly in murine urine (∼3×) after overnight feeding. Because feeding increases mesenteric blood flow, we explored the direct effects of FA in isolated murine superior mesenteric artery (SMA). Read More

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http://dx.doi.org/10.3389/fphys.2019.00277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448550PMC
March 2019
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Does Sociodemographic Background Determine the Responses to Ethical Dilemma Vignettes among Patients?

Indian J Psychol Med 2019 Mar-Apr;41(2):155-159

Department of Psychiatry and NDDTC, All India Institutes of Medical Sciences, New Delhi, India.

Background And Aims: Patients are important stakeholders in the care process and may have different viewpoints on clinical disclosure, which may be influenced by their sociodemographic and cultural background. Hence, the aim of this study was to assess whether age, gender, employment status, educational status, and other sociodemographic variables of persons with mental illness influence their views about ethical issues in clinical care.

Materials And Methods: The study was conducted at the Outpatient Department of a tertiary care mental health/de-addiction center in North India. Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_110_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436418PMC

Correlates of benzodiazepine dependence in patients with depression followed up in a psychiatric outpatient unit in Tunisia.

J Ethn Subst Abuse 2019 Apr 14:1-13. Epub 2019 Apr 14.

a Faculty of Medicine of Tunis , University of Tunis el Manar , Tunis , Tunisia.

Benzodiazepines may be prescribed to manage anxiety and insomnia in patients with depression. However, as noticed during our daily practice, a considerable proportion of patients treated for depression and receiving benzodiazepines developed a dependence to these medicines. Our aims were to estimate the proportion of patients with depression who develop a benzodiazepine dependence and to identify its correlates. Read More

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http://dx.doi.org/10.1080/15332640.2019.1589611DOI Listing

VMAT2 gene (SLC18A2) variants associated with a greater risk for developing opioid dependence.

Pharmacogenomics 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

Aim: To determine if selected serotonergic and noradrenergic gene variants are associated with heroin addiction.

Subjects & Methods: A total of 126 variants in 19 genes in subjects with Dutch European ancestry from The Netherlands. Subjects included 281 opioid-dependent volunteers in methadone maintenance or heroin-assisted treatment, 163 opioid-exposed but not opioid-dependent volunteers who have been using illicit opioids but never became opioid-dependent and 153 healthy controls. Read More

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http://dx.doi.org/10.2217/pgs-2018-0137DOI Listing
April 2019
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