78,791 results match your criteria Addiction Abingdon England[Journal]


The effect of ellagic acid on spinal cord and sciatica function in a mice model of multiple sclerosis.

J Biochem Mol Toxicol 2020 Jul 8:e22564. Epub 2020 Jul 8.

Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Multiple sclerosis (MS) is a well-known neurodegenerative disorder, causing toxicity in different organs, such as spinal cord tissue. The goal of this study was to investigate the protective effect of ellagic acid (EA) against spinal cord and sciatica function in cuprizone (Cup)-induced demyelination model. Animals were divided into six equal groups. Read More

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http://dx.doi.org/10.1002/jbt.22564DOI Listing
July 2020
1.925 Impact Factor

Stress and Perception of Procedural Pain Management in Chinese Parents of Children with Cancer.

J Pain Symptom Manage 2020 Jul 5. Epub 2020 Jul 5.

The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR. Electronic address:

Objectives: Children with cancer are exposed to repeated painful and invasive procedures. This study examines Chinese parents' stress and perception towards their children's procedural pain-control.

Methods: We recruited 265 parents of children (aged <18 years) diagnosed with hematological cancer (74. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2020.06.028DOI Listing

Inbred Substrain Differences Influence Neuroimmune Response and Drinking Behavior.

Alcohol Clin Exp Res 2020 Jul 8. Epub 2020 Jul 8.

Waggoner Center for Alcoholism and Addiction Research, The University of Texas at Austin, Austin, TX, 78712, USA.

Background: The inbred mouse strain C57BL/6 is widely used in both models of addiction and immunological disease. However, there are pronounced phenotypic differences in ethanol consumption and innate immune response between B6 substrains. The focus of this study was to examine the effects of substrain on innate immune response and neuroimmune-induced escalation of voluntary ethanol consumption. Read More

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http://dx.doi.org/10.1111/acer.14410DOI Listing

Impulsiveness and Emotional Dysregulation as Stable Features in Borderline Personality Disorder Outpatients Over Time.

J Nerv Ment Dis 2020 Jul 6. Epub 2020 Jul 6.

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Large-scale longitudinal studies show that specific borderline personality disorder (BPD) symptoms are more likely to remit over time, suggesting that clinical features of BPD may vary between younger patients and older ones. The objective of the present report is to provide a direct comparison between younger (age 18-25 years; n = 44) and older (age 40-59 years; n = 49) BPD patients on the nine DSM-4 BPD criteria (self-harm, emotional dysregulation, impulsiveness, and work and social functioning). Younger and older patients reported similar levels of impulsiveness, emotional dysregulation, and work and social functional impairment. Read More

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http://dx.doi.org/10.1097/NMD.0000000000001204DOI Listing

Uncovering the analgesic effects of a pH-dependent mu-opioid receptor agonist using a model of non-evoked ongoing pain.

Pain 2020 Jun 24. Epub 2020 Jun 24.

Department of Anesthesiology, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany.

Currently, opioids targeting mu-opioid receptors (MOR) are the most potent drugs for acute and cancer pain. However, opioids produce adverse side effects such as constipation, respiratory depression, or addiction potential. We recently developed (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), a compound that does not evoke central or intestinal side effects due to its selective activation of MOR at low pH in peripheral injured tissues. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001968DOI Listing

Commentary on Evans et al. (2020): the complex interplay between adolescent substance use, internalizing and externalizing symptoms.

Authors:
João Picoito

Addiction 2020 Jul 8. Epub 2020 Jul 8.

Department of Child and Adolescent Psychiatry, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

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http://dx.doi.org/10.1111/add.15171DOI Listing

INTERNET ADDICTION AMONG ADOLESCENTS IN A WESTERN BRAZILIAN AMAZONIAN CITY.

Rev Paul Pediatr 2021 3;39:e2019270. Epub 2020 Jul 3.

Universidade Federal do Acre, Rio Branco, AC, Brazil.

Objective: Analyze the prevalence and factors associated with internet addiction in a sample of high school adolescents in Acre, a state in northern Brazil.

Methods: A population-based cross-sectional study was conducted with 1,387 adolescents between 14 and 18 years old enrolled in high schools in the city of Rio Branco, Acre. A structured questionnaire with questions about demographics, family and behavioral patterns was applied. Read More

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http://dx.doi.org/10.1590/1984-0462/2021/39/2019270DOI Listing

Energy sensors in drug addiction: A potential therapeutic target.

Addict Biol 2020 Jul 7:e12936. Epub 2020 Jul 7.

Instituto de Investigación Biomédica de Málaga (IBIMA), UGC Salud Mental, Hospital Regional Universitario de Málaga, Málaga, Spain.

Addiction is defined as the repeated exposure and compulsive seek of psychotropic drugs that, despite the harmful effects, generate relapse after the abstinence period. The psychophysiological processes associated with drug addiction (acquisition/expression, withdrawal, and relapse) imply important alterations in neurotransmission and changes in presynaptic and postsynaptic plasticity and cellular structure (neuroadaptations) in neurons of the reward circuits (dopaminergic neuronal activity) and other corticolimbic regions. These neuroadaptation mechanisms imply important changes in neuronal energy balance and protein synthesis machinery. Read More

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http://dx.doi.org/10.1111/adb.12936DOI Listing

Synonymous variants associated with Alzheimer disease in multiplex families.

Neurol Genet 2020 Aug 8;6(4):e450. Epub 2020 Jun 8.

The Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.E.A., B.V., R.L., P.L.J., R.M., I.S.-M., C.R.); The Gertrude H. Sergievsky Center (M.T., D.R.-D., R.L., R.M., C.R.); Department of Neurology (P.L.J., R.M., C.R.); Department of Epidemiology (R.M., C.R.); Department of Psychiatry (R.M.), Columbia University, New York; Department of Pathology and Cell Biology (M.E.A., I.S.-M.), Columbia University, New York; Rush Alzheimer's Disease Center (D.A.B.); Department of Neurological Sciences (D.A.B.); Department of Pathology (D.A.B.), Rush University Medical Center, Chicago, IL; Center for Innovation in Brain Science , Departments of Pharmacology and Neurology , University of Arizona College of Medicine (M.T.), Tucson; Department of Medicine (R.L.), College of Physicians and Surgeons, Columbia University, New York, NY; School of Medicine (M.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; and The Krembil Centre for Neuroinformatics (D.F.), Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

Objective: Synonymous variants can lead to disease; nevertheless, the majority of sequencing studies conducted in Alzheimer disease (AD) only assessed coding variation.

Methods: To detect synonymous variants modulating AD risk, we conducted a whole-genome sequencing study on 67 Caribbean Hispanic (CH) families multiply affected by AD. Identified disease-associated variants were further assessed in an independent cohort of CHs, expression quantitative trait locus (eQTL) data, brain autopsy data, and functional experiments. Read More

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http://dx.doi.org/10.1212/NXG.0000000000000450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323483PMC

Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain.

Sci Adv 2020 Jun 24;6(26):eaba0154. Epub 2020 Jun 24.

Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Sant Joan d'Alacant, Spain.

Already moderate alcohol consumption has detrimental long-term effects on brain function. However, how alcohol produces its potent addictive effects despite being a weak reinforcer is a poorly understood conundrum that likely hampers the development of successful interventions to limit heavy drinking. In this translational study, we demonstrate widespread increased mean diffusivity in the brain gray matter of chronically drinking humans and rats. Read More

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http://dx.doi.org/10.1126/sciadv.aba0154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314532PMC

Adolescent problematic internet use and parental mediation: A Bangladeshi structured interview study.

Addict Behav Rep 2020 Dec 1;12:100288. Epub 2020 Jun 1.

Undergraduate Research Organization, Savar, Dhaka, Bangladesh.

Internet-related problems such as excessive internet use, problematic internet use (PIU), and internet addiction, are becoming increasingly studied among Bangladeshi adult students, but there has been little research among adolescents. In Bangladesh, there has been no research examining the role of parental mediation in their children's internet use. Therefore, the present structured interview study investigated Bangladeshi adolescent PIU and its associated socio-demographics, internet use behaviors, and the parental mediation role among 350 high school students residing in Dhaka. Read More

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http://dx.doi.org/10.1016/j.abrep.2020.100288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330868PMC
December 2020

Hispanic participants in the National Institute on Drug Abuse's Clinical Trials Network: A scoping review of two decades of research.

Addict Behav Rep 2020 Dec 1;12:100287. Epub 2020 Jun 1.

College of Social Work, Florida State University, 296 Champions Way, UCC 3407, Tallahassee, FL 32309, United States.

Introduction: Hispanics significantly underutilize substance abuse treatment and are at greater risk for poor treatment outcomes and dropout. Two decades of research from the National Drug Abuse Treatment Clinical Trials Network (CTN) offers an opportunity to increase our understanding in how to address the disparities experienced by Hispanics in substance abuse treatment.

Methods: A scoping review was utilized to determine what has been learned from the CTN about Hispanic populations with substance use disorder. Read More

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http://dx.doi.org/10.1016/j.abrep.2020.100287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330873PMC
December 2020

Factors associated with quality of life trajectories among inpatients treated for alcohol use disorders: A prospective cohort study.

Addict Behav Rep 2020 Dec 20;12:100285. Epub 2020 May 20.

Department of Research and Development, Clinic of Substance Use and Addiction Medicine, St. Olavs University Hospital, Trondheim, Norway.

Aims: The main study purpose was to investigate patient- and treatment-related factors associated with overall quality of life (OQOL) trajectories during and after inpatient alcohol use disorder (AUD) treatment.

Design: A large-scale prospective multicenter cohort study of patients with different substance use disorder (SUD) types who were consecutively admitted for inpatient SUD treatment. Data were obtained at treatment entry (T1), discharge (T2), three months after discharge (T3), and one year after discharge (T4). Read More

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http://dx.doi.org/10.1016/j.abrep.2020.100285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330870PMC
December 2020

Alternative flavored and unflavored tobacco product use and cigarette quit attempts among current smokers experiencing homelessness.

Addict Behav Rep 2020 Dec 4;12:100280. Epub 2020 May 4.

University of California, San Francisco, Division of General Internal Medicine, 1001 Potrero Avenue, San Francisco, CA 94110, USA.

Introduction: Alternative tobacco product (ATP) use is common in the general population; however, few studies have explored ATP among individuals experiencing homelessness. We recruited individuals experiencing homelessness who were current cigarette smokers to explore flavored and unflavored ATP use and its association with past-year cigarette quit attempts.

Methods: Using time-location sampling, we recruited participants from eight service sites in San Francisco, CA between December 2017 and July 2018. Read More

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http://dx.doi.org/10.1016/j.abrep.2020.100280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330871PMC
December 2020

Treatment effects on neurometabolite levels in schizophrenia: A meta-analysis dataset of proton magnetic resonance spectroscopy.

Data Brief 2020 Aug 16;31:105862. Epub 2020 Jun 16.

Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.

This article describes a dataset for a meta-analysis that aimed to investigate the effects of treatment on the neurometabolite status in patients with schizophrenia (DOI of original article: https://doi.org/10.1016/j. Read More

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http://dx.doi.org/10.1016/j.dib.2020.105862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327820PMC

Nanotechnology in Chronic Pain Relief.

Front Bioeng Biotechnol 2020 19;8:682. Epub 2020 Jun 19.

Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Increasing awareness of chronic pain due to both injury and disease have encouraged drug companies and pharmaceutical researchers alike to design and fabricate better, more specific drugs for pain relief. However, overuse of clinically available pain medication has caused a multitude of negative repercussions, including drug tolerance, addiction, and other severe side effects, which can prolong suffering and reduce pain mediation. Applications of nanotechnology to the field of drug delivery has sought to enhance the treatment efficiency, lower side effects, and mitigate the formation of tolerance. Read More

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http://dx.doi.org/10.3389/fbioe.2020.00682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317276PMC

Using Group Concept Mapping to Develop a Conceptual Model of Housing and Community-Based Residential Settings for Adults With Severe Mental Illness.

Front Psychiatry 2020 19;11:430. Epub 2020 Jun 19.

Research Centre, Institut universitaire en santé mentale de Montréal (IUSMM), Montreal, QC, Canada.

Background: Most existing conceptual models of residential environments and housing programs were developed over a decade ago or lack comprehensiveness. The attributes to be used to describe housing programs with adequate specification remain unclear including the attributes that mediate service user outcomes. In this study, group concept mapping was used to develop a conceptual model of housing and community-based residential settings for adults with severe mental illness based on stakeholder perceptions and values. Read More

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http://dx.doi.org/10.3389/fpsyt.2020.00430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319103PMC

Pharmacological Manipulation of K 7 Channels as a New Therapeutic Tool for Multiple Brain Disorders.

Front Physiol 2020 19;11:688. Epub 2020 Jun 19.

Department of Cellular and Integrative Physiology, University of Texas Health San Antonio, San Antonio, TX, United States.

K 7 ("M-type," KCNQ) K currents, play dominant roles in controlling neuronal excitability. They act as a "brake" against hyperexcitable states in the central and peripheral nervous systems. Pharmacological augmentation of M current has been developed for controlling epileptic seizures, although current pharmacological tools are uneven in practical usefulness. Read More

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http://dx.doi.org/10.3389/fphys.2020.00688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317068PMC

Medical Student Attitudes Toward Substance Use Disorders Before and After a Skills-Based Screening, Brief Intervention, and Referral to Treatment (SBIRT) Curriculum.

Adv Med Educ Pract 2020 30;11:455-461. Epub 2020 Jun 30.

Department of Psychiatry, Columbia University, New York, NY, USA.

Purpose: Screening, Brief Intervention, and Referral to Treatment (SBIRT) is an evidence-based framework for assessing and addressing risky substance use. This study evaluated the substance-related attitudes of medical students who participated in an Enhanced Pre-Clinical SBIRT Curriculum designed to reduce stigma, help students empathize with the experiences of people using alcohol and drugs, understand substance use in-context, and feel more optimistic about efforts to prevent and treat substance use disorders (SUDs).

Methods: Students (N=118; 73. Read More

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http://dx.doi.org/10.2147/AMEP.S251391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335270PMC

Effects of the Alpha-2 Adrenergic Receptor Agonist Lofexidine on Food-Cocaine Choice in Socially Housed Cynomolgus Monkeys.

J Pharmacol Exp Ther 2020 Jul 7. Epub 2020 Jul 7.

Wake Forest School of Medicine.

Although norepinephrine (NE) does not appear to play prominent a role in mediating the abuse-related effects of cocaine, studies have indicated that NE alpha-2 receptor agonists can attenuate reinstatement of extinguished cocaine self-administration in rats and monkeys and can decrease cocaine craving in humans. In the present studies, we examined the effects of two alpha-2 receptor agonists, lofexidine and guanfacine, on choice between food and cocaine (0.0-0. Read More

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http://dx.doi.org/10.1124/jpet.120.266007DOI Listing

Hot wires and film boiling: Another look at carbonyl formation in electronic cigarettes.

Chem Res Toxicol 2020 Jul 8. Epub 2020 Jul 8.

Electronic cigarettes (ECIGS) are a class of tobacco products that emit a nicotine-containing aerosol by heating and vaporizing a liquid. Apart from initiating nicotine addiction in nonsmokers, a persistent concern about these products is that their emissions often include high levels of carbonyl species, toxicants thought to cause most non-cancer pulmonary disease in smokers. This study examined whether the phenomenon of film boiling can account for observations of high carbonyl emissions under certain operating conditions, and if so, whether film boiling theory can be invoked to predict conditions where high carbonyl emissions are likely. Read More

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http://dx.doi.org/10.1021/acs.chemrestox.0c00196DOI Listing

Management pathway for emergency department patients in the setting of the opioid epidemic and emergency department overcrowding.

Clin Exp Emerg Med 2020 Jun 30;7(2):131-135. Epub 2020 Jun 30.

Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA.

Objective: The United States is currently in the midst of a major opioid addiction epidemic, of which the primary drivers are a sharp increase in prescription opioid pain medications, their misuse, and the inordinate illicit use of opioids. Declared a national health emergency, the opioid crisis puts enormous pressure on various systems, including increasing overcrowding in emergency departments (EDs) and forced changes in prescribing practices. We are piloting a newlydeveloped ED opiate pathway to streamline ED care for patients who frequently present at the ED for chronic pain management or other recurrent pain-causing medical problems. Read More

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http://dx.doi.org/10.15441/ceem.19.067DOI Listing

Mind over Matter: Testing the Efficacy of an Online Randomized Controlled Trial to Reduce Distraction from Smartphone Use.

Int J Environ Res Public Health 2020 Jul 5;17(13). Epub 2020 Jul 5.

International Gaming Research Unit, Psychology Department, Nottingham Trent University, Nottingham NG1 4FQ, UK.

Evidence suggests a growing call for the prevention of excessive smartphone and social media use and the ensuing distraction that arises affecting academic achievement and productivity. A ten-day online randomized controlled trial with the use of smartphone apps, engaging participants in mindfulness exercises, self-monitoring and mood tracking, was implemented amongst UK university students ( = 143). Participants were asked to complete online pre- and post-intervention assessments. Read More

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http://dx.doi.org/10.3390/ijerph17134842DOI Listing

Interaction of Socioeconomic Status with Risky Internet Use, Gambling and Substance Use in Adolescents from a Structurally Disadvantaged Region in Central Europe.

Int J Environ Res Public Health 2020 Jul 3;17(13). Epub 2020 Jul 3.

Department of Addictology, General University Hospital in Prague, Apolinářská 447/4, 128 00 Prague, Czech Republic.

Background And Aims: The current level of knowledge concerning the effect of socioeconomic status (SES) on internet use, gambling, and substance use in structurally disadvantaged regions is scarce. The objective of this study was an investigation of the relationship between SES and risky internet use, gambling and substance use in a structurally disadvantaged region in Central Europe.

Methods: A cross-sectional survey was conducted among high school students ( = 1063) in a Czech structurally disadvantaged region in autumn 2017. Read More

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http://dx.doi.org/10.3390/ijerph17134803DOI Listing

The Conceptual Framework of Dual Disorders and Its Flaws.

J Clin Med 2020 Jul 3;9(7). Epub 2020 Jul 3.

G. De Lisio Institute of Behavioral Sciences, 56100 Pisa, Italy.

When psychiatric illness and substance use disorder coexist, the clinical approach to the patient is, unsurprisingly, awkward. This fact is due to a cultural context and, more directly, to the patient's psychiatric condition and addiction behaviors-a situation that does not favor a scientific approach. In dual disorder facilities, several types of professionals work together: counselors, social workers, psychologists, and psychiatrists. Read More

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http://dx.doi.org/10.3390/jcm9072098DOI Listing

Preclinical research of analgesic αO-conotoxin GeXIVA without addiction side effect.

Toxicon 2020 Apr;177 Suppl 1:S3

Key Laboratory of Tropical Biological Resources, Ministry of Education, Key Laboratory for Marine Drug of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou Hainan, 570228, China.

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http://dx.doi.org/10.1016/j.toxicon.2019.10.016DOI Listing

International Consensus Statement for the Screening, Diagnosis, and Treatment of Adolescents with Concurrent Attention-Deficit/Hyperactivity Disorder and Substance Use Disorder.

Eur Addict Res 2020 Jul 7:1-10. Epub 2020 Jul 7.

Parnassia Addiction Research Centre (PARC), Parnassia Psychiatric Institute, The Hague, The Netherlands.

Background: Childhood attention-deficit/hyperactivity disorder (ADHD) is a risk factor for substance misuse and substance use disorder (SUD) in adolescence and (early) adulthood. ADHD and SUD also frequently co-occur in treatment-seeking adolescents, which complicates diagnosis and treatment and is associated with poor treatment outcomes. Research on the effect of treatment of childhood ADHD on the prevention of adolescent SUD is inconclusive, and studies on the diagnosis and treatment of adolescents with ADHD and SUD are scarce. Read More

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http://dx.doi.org/10.1159/000508385DOI Listing

Perceived school climate and problematic internet use among adolescents: Mediating roles of school belonging and depressive symptoms.

Addict Behav 2020 Jun 7;110:106501. Epub 2020 Jun 7.

School of Education Science, Jiaying University, Meizhou, Guangdong 514015, China.

Prior studies have found that a positive school climate can prevent adolescents from developing problematic Internet use (PIU), yet gaps remain in identifying the proximal mechanisms. Guided by social control theory and the self-medication hypothesis, this study examined the mediating roles of adolescents' sense of school belonging and depressive symptoms in the relationship between perceived school climate (PSC) and adolescent PIU. A total of 2,758 adolescents (M = 13. Read More

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http://dx.doi.org/10.1016/j.addbeh.2020.106501DOI Listing

Long-term exposure to ephedrine leads to neurotoxicity and neurobehavioral disorders accompanied by up-regulation of CRF in prefrontal cortex and hippocampus in rhesus macaques.

Behav Brain Res 2020 Jul 4:112796. Epub 2020 Jul 4.

Department of Radiology, The First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Shantou, 515041, Guangdong, China; Shantou University Medical College, No. 22 Xinling Road, Shantou, 515041, Guangdong, China; Guangdong Key Laboratory of Medical Molecular Imaging, No. 57 Changping Road, Shantou, 515041, Guangdong, China. Electronic address:

Drug addiction continues to threaten the health and welfare of people worldwide, and ephedrine abuse is a serious drug problem in many areas of the world. Ephedrine toxicity is thought to induce behavioral effects primarily through actions on the central nervous system. The corticotropin-releasing factor (CRF) system plays an important role in regulating behavioral effects induced by addictive drugs, but whether CRF is related to ephedrine toxicity remains unclear. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112796DOI Listing

Which conditions should be considered as disorders in the International Classification of Diseases (ICD-11) designation of "other specified disorders due to addictive behaviors"?

J Behav Addict 2020 Jun 30. Epub 2020 Jun 30.

21Departments of Psychiatry, Neuroscience and Child Study, Yale University School of Medicine, New Haven, CT, USA.

Background: Gambling and gaming disorders have been included as "disorders due to addictive behaviors" in the International Classification of Diseases (ICD-11). Other problematic behaviors may be considered as "other specified disorders due to addictive behaviors (6C5Y)."

Methods: Narrative review, experts' opinions. Read More

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http://dx.doi.org/10.1556/2006.2020.00035DOI Listing

Impact of COVID-19 on gaming disorder: Monitoring and prevention.

J Behav Addict 2020 Jul 2. Epub 2020 Jul 2.

1Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 100 Tzyou 1st Rd, Kaohsiung City, 807, Taiwan, ROC.

The global coronavirus disease 2019 (COVID-19) outbreak has necessitated physical distancing, lockdown, contact tracing, and self-quarantine so as to prevent the spread of the disease. Amid the outbreak, gaming data usage has reportedly increased in the United States, and game download volume has reached a record high in Europe. Because gaming can be used to cope with the psychological stress from the outbreak, therefore mental health professionals should be aware of how increased gaming during the pandemic may contribute to risk of gaming disorder, especially if the pandemic persists. Read More

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http://dx.doi.org/10.1556/2006.2020.00040DOI Listing

Gambling in adolescence: a narrative review of the last 20 years.

J Addict Dis 2020 Jul 7:1-20. Epub 2020 Jul 7.

Department of Cognitive Sciences, Psychology, Educational and Cultural Studies (COSPECS), University of Messina, Messina, Italy.

Background: Gambling has increasingly become a problem in adolescence over the last 20 years. Previous research has failed to identify exactly the level of involvement of adolescents in gambling, yet a relevant presence of addictive behaviors was noticed.

Objective: This narrative review highlights the implications of adolescent gambling, taking into consideration the main risk and protection factors aimed at limiting gambling activity, as well as the main links with the impulse-control disorder, addiction, and behavioral addiction. Read More

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http://dx.doi.org/10.1080/10550887.2020.1782557DOI Listing

Validity and reliability of the Persian version of "drug-related knowledge and attitude questionnaire" among Iranian medical students.

J Addict Dis 2020 Jul 7:1-6. Epub 2020 Jul 7.

Research Center for Addiction and Risky Behaviors, Department of Psychiatry, Iran University of Medical Sciences, Tehran, Iran.

Background: Promoting drug-related knowledge and improving relevant attitudes among students are of crucial importance toward the prevention of drug misuse. Objective: This study aimed to assess the validity and reliability of the "drug-related knowledge and attitude questionnaire" among Iranian medical students. Methods: The participants of this cross-sectional study were students of Iran University of Medical Sciences. Read More

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http://dx.doi.org/10.1080/10550887.2020.1787769DOI Listing

A randomized controlled trial to compare group motivational interviewing to very brief advice for the effectiveness of a workplace smoking cessation counseling intervention.

J Addict Dis 2020 Jul 7:1-10. Epub 2020 Jul 7.

Occupational Medicine, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Background: Studies show that smokers have a lower work performance due to time spent smoking, increased fatigue perception and are more absent from work due to smoking-related diseases. The workplace could represent an important location to promote smoking cessation.

Methods: This study is a multi-center, controlled trial for smoking cessation counseling at the participants' workplace, where 656 randomized participants received four sessions of group motivational interviewing or four sessions of very brief advice and were followed up for 52 weeks. Read More

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http://dx.doi.org/10.1080/10550887.2020.1782564DOI Listing

Psycho-Social Correlates of Opioid Use Disorder among the US Adult Population: Evidence from the National Survey on Drug Use and Health, 2015-2018.

Subst Use Misuse 2020 Jul 7:1-9. Epub 2020 Jul 7.

South Carolina SmartState Center for Healthcare Quality, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.

Background: The United States (US) has experienced an opioid epidemic over the last two decades. Drug overdose deaths increased by 21% from 2015 to 2016, with two-thirds of these deaths attributed to opioid use disorder (OUD). This study assessed the psycho-social correlates associated with OUD over 2015-2018 in the US. Read More

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http://dx.doi.org/10.1080/10826084.2020.1788086DOI Listing

Factors associated with injecting-related risk behaviors among people who inject drugs: a systematic review and meta-analysis study.

J Addict Dis 2020 Jul 7:1-18. Epub 2020 Jul 7.

Student Research Committee, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

We conducted this systematic review and meta-analysis study to better understand the factors (being drug use, drug type (methamphetamine vs others), sex partner, frequency of injection, homelessness and being HIV positive) associated with injecting-related risk behaviors (lending and/or borrowing already used syringes) among people who inject drugs (PWID). We searched the English language citations in PubMed, Science Direct, Web of Science, and Cochrane electronic databases for previous studies on risk behaviors among PWID. Two independent researchers reviewed all search results, screened for eligibility and extracted data independently. Read More

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http://dx.doi.org/10.1080/10550887.2020.1781346DOI Listing

'Extreme personal stress' and 'a lot of pain': Exploring the physical, mental and social contexts of extramedical pharmaceutical opioid use in Australian paramedic case descriptions.

Drug Alcohol Rev 2020 Jul 7. Epub 2020 Jul 7.

Turning Point, Eastern Health, Melbourne, Australia.

Introduction And Aims: Despite growing concerns over the extramedical use of pharmaceutical opioids, few studies have focused on the contexts that shape this use or how it might lead to harm. There is also limited research examining how contexts might vary across different opioids, such as those with well-established abuse liabilities (e.g. Read More

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http://dx.doi.org/10.1111/dar.13118DOI Listing

Commentary on Rossow et al. (2020): The directions and tools to pursue a public health-orientated alcohol policy.

Addiction 2020 Jul 7. Epub 2020 Jul 7.

All India Institute of Medical Sciences, Rishikesh, India.

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http://dx.doi.org/10.1111/add.15172DOI Listing

The 2019-nCoV pandemic in the global south: A Tsunami ahead.

EClinicalMedicine 2020 Jun 19;23:100384. Epub 2020 May 19.

Department of Medicine, University of California San Diego School of Medicine, La Jolla, California, United States.

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http://dx.doi.org/10.1016/j.eclinm.2020.100384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234938PMC

[Parental Factors Associated with Smartphone Overuse in Preschoolers: A Systematic Review and Meta-Analysis].

J Korean Acad Nurs 2020 Jun;50(3):349-368

College of Nursing, Seoul National University, Seoul, Korea.

Purpose: This study aimed to identify parental factors associated with smartphone overuse in preschoolers.

Methods: A systematic review was conducted according to PRISMA guidelines. Relevant studies published in peer-reviewed journals from 2009 to June 2019 were identified through systematic search in 10 electronic databases (PubMed, CINAHL, Cochrane Central, EMBASE, Web of Science, NDSL, KISS, KMbase, KoreaMed, and RISS). Read More

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http://dx.doi.org/10.4040/jkan.19186DOI Listing

Infralimbic Cortex biases Preference Decision Making for Offspring over Competing Cocaine Associated Stimuli in New Mother Rats.

eNeuro 2020 Jul 1. Epub 2020 Jul 1.

Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102 USA.

In the context of drug abuse, converging evidence suggests that cocaine use in new mothers is significantly reduced by the competing motivation related to child rearing. Given the demonstrated importance of the medial prefrontal cortex (mPFC) in decision making processes, we investigated the contribution of distinct regions of the mPFC (anterior cingulate, prelimbic, infralimbic) to decision-making in new mother rats performing a concurrent pup/cocaine choice conditioned place preference (CPP) task. When given a choice, inactivation of infralimbic cortex significantly biased decision-making of mother rats towards cocaine-associated cues, highly contrasting the distribution of preferences by control groups. Read More

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http://dx.doi.org/10.1523/ENEURO.0460-19.2020DOI Listing

Alcohol consumption and internalising disorders in young adults of ALSPAC: a population-based study.

J Epidemiol Community Health 2020 Jul 6. Epub 2020 Jul 6.

School of Social and Community Medicine, University of Bristol, Bristol, UK.

Introduction: Depression and harmful alcohol consumption contribute significantly to the global health burden, but in young adults, this relationship is under-researched and conflicted. The aim of this study was to determine the sex-based prevalence and the association between internalising disorders such as depression and alcohol use disorders.

Method: Using the Avon Longitudinal Study of Parents and Children, we assessed the sex-specific prevalence of International Classification of Diseases,Tenth Revision diagnosed generalised anxiety disorder (GAD), depression and fear-based anxieties (FBA) at 24 years (n=3572). Read More

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http://dx.doi.org/10.1136/jech-2020-213922DOI Listing

Discovery of phenanthridine analogues as novel chemical probes disrupting the binding of DNA to ΔFosB homodimers and ΔFosB/JunD heterodimers.

Bioorg Med Chem Lett 2020 Aug 6;30(16):127300. Epub 2020 Jun 6.

Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, United States; Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555, United States. Electronic address:

The transcription factor ΔFosB accumulates in response to chronic insults such as drugs of abuse, L-3,4-dihydroxyphenylalanine (l-DOPA) or stress in specific regions of the brain, triggering long lasting neural and behavioral changes that underlie aspects of drug addiction, dyskinesia, and depression. Thus, small molecule chemical probes are urgently needed to investigate biological functions of ΔFosB. Herein we describe the identification of a novel phenanthridine analogue ZL0220 (27) as an active and promising ΔFosB chemical probe with micromolar inhibitory activities against ΔFosB homodimers and ΔFosB/JunD heterodimers. Read More

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http://dx.doi.org/10.1016/j.bmcl.2020.127300DOI Listing

Recruiting a representative sample of urban South Australian Aboriginal adults for a survey on alcohol consumption.

BMC Med Res Methodol 2020 Jul 6;20(1):183. Epub 2020 Jul 6.

Faculty of Medicine and Health, Discipline of Addiction Medicine, NHMRC Centre of Research Excellence in Indigenous Health and Alcohol, The University of Sydney, King George V Building, 83-117 Missenden Road, Camperdown, NSW, 2050, Australia.

Background: Population estimates of alcohol consumption vary widely among samples of Aboriginal and Torres Strait Islander (Indigenous) Australians. Some of this difference may relate to non-representative sampling. In some communities, household surveys are not appropriate and phone surveys not feasible. Read More

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http://dx.doi.org/10.1186/s12874-020-01067-yDOI Listing

Developing a national road traffic safety education program in Iran.

BMC Public Health 2020 Jul 6;20(1):1064. Epub 2020 Jul 6.

Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Education is a pivot included Decade of Action for Road Safety initiative, which has reduced deaths caused by accidents in developed countries. Given the circumstances of each country, a proper education program is necessary. Thus, the aim of this study was to develop the National Road Traffic Safety Education Program (NRTSEP) and reduce Road Traffic Injuries (RTIs). Read More

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http://dx.doi.org/10.1186/s12889-020-09142-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336625PMC

Nonconsensual Dose Reduction Mandates are Not Justified Clinically or Ethically: An Analysis.

J Law Med Ethics 2020 Jun;48(2):259-267

Stefan G. Kertesz, M.D., M.Sc., is a professor at the Department of Medicine, UAB School of Medicine and research investigator at the Birmingham VA Medical Center. He is a board-certified internal medicine (American Board of Internal Medicine) and addiction medicine physician (American Board of Addiction Medicine). His research career began in 2000 and he has been funded by both the National Institute on Drug Abuse and the Health Services Research & Development Branch of the Department of Veterans Affairs. He received his MD from Harvard Medical School in Boston, MA and his MSc from Boston University School of Public Health in Boston, MA. Ajay Manhapra, M.D., is Lecturer at Yale School of Medicine in the Department of Psychiatry, Assistant Professor, at the Eastern Virginia Medical School in the Department of Physical Medicine and Rehabilitation and Psychiatry, and Research Scientist at the VA New England Mental Illness Research, Education and Clinical Center. Dr. Manhapra is a board-certified Internist and Addiction Medicine physician with educational, clinical and research focus on pain and addiction. He runs a unique clinic for recovering patients with severe disabling chronic pain and medication or substance dependence at Hampton VA Medical Center, where he is developing an interdisciplinary integrative model for treatment of pain and addiction. Dr. Manhapra received his medical degree from Government Medical College, Thrissur, Kerala, India, and completed his Addiction Medicine fellowship at Yale School of Medicine. Adam J. Gordon, M.D., M.P.H., is Professor of Medicine and Psychiatry at the University of Utah School of Medicine, Director of the Program for Addiction Research, Clinical Care, Knowledge, and Advocacy (PARCKA), and Chief of Addiction Medicine at VA Salt Lake City Health Care System and. He is a board-certified internal medicine (American Board of Internal Medicine) and addiction medicine physician (American Board of Preventive Medicine) with a 20-year track record of conducting research on the quality, equity, and efficiency of health care for vulnerable populations (e.g., persons with opioid use disorders, persons who are homeless, persons with hazardous alcohol use and other addiction disorders). He received his MD from University of Pittsburgh School of Medicine in Pittsburgh, PA and his MPH from the University of Pittsburgh Graduate School of Public Health in Pittsburgh, PA.

This manuscript describes the institutional and clinical considerations that apply to the question of whether to mandate opioid dose reduction in patients who have received opioids long-term. It describes how a calamitous rise in addiction and overdose involving opioids has both led to a clinical recalibration by healthcare providers, and to strong incentives favoring forcible opioid reduction by policy making agencies. Neither the 2016 Guideline issued by the Centers for Disease Control and Prevention nor clinical evidence can justify or promote such policies as safe or effective. Read More

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http://dx.doi.org/10.1177/1073110520935337DOI Listing

Prevalence and predictors of psychopathology in the war-afflicted Syrian population.

Transcult Psychiatry 2020 Jul 6:1363461520937931. Epub 2020 Jul 6.

Institute for Mental Health Policy Research, Centre for Addiction and Mental Health and Technische Universität Dresden.

Research on the psychological impact of war on affected populations is important for the planning and provision of interventions. However, most studies that address the effects of political violence have been restricted to Western countries, and even after six years of civil war in Syria, there has been no study addressing its psychological impact on the general population. The present study used an online survey to examine the level of psychological symptoms and correlates of distress in a sample of 387 subjects from different areas of Syria. Read More

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http://dx.doi.org/10.1177/1363461520937931DOI Listing

Relationship between Difficulty in Emotion Regulation and Internet Addiction in College Students: A One-Year Prospective Study.

Int J Environ Res Public Health 2020 Jul 2;17(13). Epub 2020 Jul 2.

Department of Psychiatry, School of Medicine and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

This prospective study evaluated the predictive effect of difficulty in emotion regulation on the occurrence and remission of Internet addiction (IA) and determined whether IA has a role in changing emotion regulation among college students during a follow-up period of 1 year. A total of 500 college students (262 women and 238 men) were recruited. In baseline and follow-up investigations, the levels of IA and difficulty in emotion regulation were evaluated using the Chen Internet Addiction Scale and the Difficulties in Emotion Regulation Scale (DERS), respectively. Read More

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http://dx.doi.org/10.3390/ijerph17134766DOI Listing