77,871 results match your criteria Addiction & health[Journal]


How Much Do We Know about the Biopsychosocial Predictors of Glycaemic Control? Age and Clinical Factors Predict Glycaemic Control, but Psychological Factors Do Not.

J Diabetes Res 2020 1;2020:2654208. Epub 2020 May 1.

Department of Psychiatry, Universiti Kebangsaan Malaysia Medical Centre, Malaysia.

Objective: Diabetes mellitus is one of the most common noncommunicable diseases in Malaysia. It is associated with significant complications and a high cost of treatment, especially when glycaemic control is poor. Despite its negative impact on health, data is still lacking on the possible biopsychosocial predictors of poor glycaemic control among the diabetic population. Read More

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http://dx.doi.org/10.1155/2020/2654208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222480PMC

BOLD activation during cue induced craving in adolescent inhalant users.

Asian J Psychiatr 2020 Apr 21;52:102097. Epub 2020 Apr 21.

National Drug Dependence Treatment Centre (NDDTC) All India Institute of Medical Sciences (AIIMS), New Delhi, India. Electronic address:

Inhalants are legally available substances, most of them inexpensive, which are often abused by adolescents. Craving causes their continued use and repeated relapses. There is a need to understand the cue-induced craving and the associated neural mechanisms. Read More

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http://dx.doi.org/10.1016/j.ajp.2020.102097DOI Listing

Sources of drug acquisition among females and males in the European Web Survey on Drugs.

Int J Drug Policy 2020 May 22;81:102777. Epub 2020 May 22.

European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Praça Europa 1, Cais do Sodré, 1249-289, Lisbon, Portugal. Electronic address:

Background: Social networks determine the availability of drugs, which in turn affects use patterns. Yet, there is some limited evidence that as frequency of drug use increases, people who use drugs increasingly utilize drug dealers. Further, females more often report receiving drugs for free. Read More

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http://dx.doi.org/10.1016/j.drugpo.2020.102777DOI Listing

Cognitive dynamics of intertemporal choice in gambling disorder.

Addict Behav 2020 May 8;109:106463. Epub 2020 May 8.

Gabriele d'Annunzio University, Department of Neuroscience, Imaging and Clinical Sciences, and Institute for Advanced Biomedical Technologies (ITAB), Via dei Vestini 33, 66013 Chieti scalo, Italy. Electronic address:

Gambling Disorder (GD) is a behavioral addiction characterized by the persistence of recurrent gambling behaviors despite serious adverse consequences. One of the key features of GD is a marked inability to delay gratification and an overall impairment of decision-making mechanisms. Indeed, in intertemporal choice (ITC) tasks, GD patients usually display a marked tendency to prefer smaller-sooner over larger-later rewards (temporal discounting, TD). Read More

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http://dx.doi.org/10.1016/j.addbeh.2020.106463DOI Listing

Anti-NMDA Receptor Encephalitis in a Psychiatric Covid-19 Patient: a Case Report.

Brain Behav Immun 2020 May 23. Epub 2020 May 23.

Department of Mental Health and Addiction Services, Niguarda Hospital, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2020.05.054DOI Listing

Glycogen synthase kinase-3 signaling in cellular and behavioral responses to psychostimulant drugs.

Biochim Biophys Acta Mol Cell Res 2020 May 23:118746. Epub 2020 May 23.

Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA; Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA. Electronic address:

Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase implicated in numerous physiological processes and cellular functions through its ability to regulate the function of many proteins, including transcription factors and structural proteins. GSK-3β has been demonstrated to function as a regulator of multiple behavioral processes induced by drugs of abuse, particularly psychostimulant drugs. In this review, we provide an overview of the regulation of GSK-3β activity produced by psychostimulants, and the role of GSK-3β signaling in psychostimulant-induced behaviors including drug reward, associative learning and memory which play a role in the maintenance of drug-seeking. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2020.118746DOI Listing

Comparison of 3 Treatment Strategies for Medication Overuse Headache: A Randomized Clinical Trial.

JAMA Neurol 2020 May 26. Epub 2020 May 26.

Danish Headache Center, Rigshospitalet, Glostrup, Denmark.

Importance: Medication overuse headache (MOH) is a disabling, globally prevalent disorder representing a well-known and debated clinical problem. Evidence for the most effective treatment strategy is needed.

Objective: To compare 3 treatment strategies for MOH. Read More

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http://dx.doi.org/10.1001/jamaneurol.2020.1179DOI Listing

Kratom (Mitragyna speciosa): worldwide issues.

Curr Opin Psychiatry 2020 May 20. Epub 2020 May 20.

Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida, USA.

Purpose Of Review: To inform readers about the increasingly popular Western dietary supplement, kratom (Mitragyna speciosa) and how the products are available in the Western world compared with traditional Southeast Asian use. Kratom has been traditionally used for increasing stamina of outdoor laborers (farmers), mood enhancement, pain, and opium addiction. Interestingly, kratom has been reported to have a paradoxical effect in that stimulant feelings, and sedative feelings can be obtained depending on the amount utilized. Read More

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http://dx.doi.org/10.1097/YCO.0000000000000621DOI Listing

Relationship Between Alcohol-related Family Adversity, Alcohol Use Across Adolescence, and Mental States Recognition in Young Adulthood.

J Addict Med 2020 May 22. Epub 2020 May 22.

Department of Psychiatry, Medical University of Warsaw, Warsaw, Poland (MK, AJ, MW); Department of Psychology, Center for Children and Families, Florida International University, Miami, FL (EMT); Department of Psychology, University of Warsaw, Warsaw, Poland (HS); Department of Psychology, University of Michigan, Ann Arbor, MI (HS); Department of Psychiatry, Addiction Center, University of Michigan, Ann Arbor, MI (EMT, MW, RAZ); National Information Processing Institute, Laboratory of Interactive Technologies, Warsaw, Poland (PK).

Objectives: Although a theoretical link between childhood adversity and mental states recognition has been established, empirical findings are mixed. Some prior work indicates that childhood adversity might enhance, preserve, or reduce mentalization skills in selected at-risk populations. In the current study, we examine whether the presence of risky alcohol use during adolescence moderates the association between childhood alcohol-related family adversity and mental states recognition in young adulthood. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000659DOI Listing

Assessment of the Efficacy of a Mobile Phone-Delivered Just-in-Time Planning Intervention to Reduce Alcohol Use in Adolescents: Randomized Controlled Crossover Trial.

JMIR Mhealth Uhealth 2020 May 26;8(5):e16937. Epub 2020 May 26.

Health, Work & Organizational Psychology, School of Psychology and Psychotherapy, Witten/Herdecke University, Witten/Herdecke, Germany.

Background: Interventions to reduce alcohol use typically include several elements, such as information on the risks of alcohol consumption, planning for sensible drinking, and training of protective behavioral strategies. However, the effectiveness of these individual intervention elements within comprehensive programs has not been addressed so far, but it could provide valuable insights for the development of future interventions. Just-in-time interventions provided via mobile devices are intended to help people make healthy decisions in the moment and thus could influence health behavior. Read More

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http://dx.doi.org/10.2196/16937DOI Listing

Digital Health Equity and COVID-19: The Innovation Curve Cannot Reinforce the Social Gradient of Health.

J Med Internet Res 2020 May 25. Epub 2020 May 25.

Virtual Mental Health and Outreach, Centre for Addiction and Mental Health, 250 College StRoom 825, Toronto, CA.

Unstructured: Digital health innovations have been rapidly implemented and scaled to provide solutions to health delivery challenges posed by the coronavirus disease (COVID-19) pandemic. This has provided people with ongoing access to vital health services while minimizing their potential exposure to infection and allowing them to maintain social distancing. However, these solutions may have unintended consequences for health equity. Read More

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http://dx.doi.org/10.2196/19361DOI Listing

Functional connectome contractions in temporal lobe epilepsy: Microstructural underpinnings and predictors of surgical outcome.

Epilepsia 2020 May 26. Epub 2020 May 26.

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.

Objective: Temporal lobe epilepsy (TLE) is the most common drug-resistant epilepsy in adults. Although it is commonly related to hippocampal pathology, increasing evidence suggests structural changes beyond the mesiotemporal lobe. Functional anomalies and their link to underlying structural alterations, however, remain incompletely understood. Read More

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http://dx.doi.org/10.1111/epi.16540DOI Listing

Effect of alcohol prohibition on liver cirrhosis mortality rates in Canada from 1901 to 1956: A time-series analysis.

Drug Alcohol Rev 2020 May 25. Epub 2020 May 25.

Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Canada.

Introduction And Aims: The extent to which alcohol consumption in Canada was affected by alcohol prohibition in the early 20th century remains unclear. Since there is a dearth of data on consumption during this time, we estimated the effect of alcohol prohibition on alcohol consumption, as measured by changes in liver cirrhosis mortality rates in Canada.

Design And Methods: Annual liver cirrhosis mortality data were obtained for 1901 to 1956 for the provinces of Alberta, British Columbia, Manitoba, New Brunswick, Nova Scotia, Ontario and Saskatchewan. Read More

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http://dx.doi.org/10.1111/dar.13089DOI Listing

Cholinergic Receptors and Addiction.

Curr Top Behav Neurosci 2020 May 26. Epub 2020 May 26.

Department of Psychiatry and Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

Human behavior can be controlled by physical or psychological dependencies associated with addiction. One of the most insidious addictions in our society is the use of tobacco products which contain nicotine. This addiction can be associated with specific receptors in the brain that respond to the natural neurotransmitter acetylcholine. Read More

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http://dx.doi.org/10.1007/7854_2020_139DOI Listing

Bptf determines oncogenic addiction in aggressive B-cell lymphomas.

Oncogene 2020 May 25. Epub 2020 May 25.

Epithelial Carcinogenesis Group, Molecular Oncology Programme, Spanish National Cancer Research Centre-CNIO, 28029, Madrid, Spain.

Chromatin remodeling factors contribute to establish aberrant gene expression programs in cancer cells and therefore represent valuable targets for therapeutic intervention. BPTF (Bromodomain PhD Transcription Factor), a core subunit of the nucleosome remodeling factor (NURF), modulates c-MYC oncogenic activity in pancreatic cancer. Here, we analyze the role of BPTF in c-MYC-driven B-cell lymphomagenesis using the Eμ-Myc transgenic mouse model of aggressive B-cell lymphoma. Read More

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http://dx.doi.org/10.1038/s41388-020-1331-3DOI Listing

Behavioral Conditioning, the Placebo Effect, and Emergency Department Pain Management.

Authors:
Kenneth Frumkin

J Emerg Med 2020 May 22. Epub 2020 May 22.

Emergency Medicine Department, Naval Medical Center, Portsmouth, Virginia.

Animals and humans can be readily conditioned to associate a novel stimulus (often a unique taste) by pairing it with the effects of a drug or other agent. When later presented with the stimulus alone, their body's systems respond as if the drug or agent were given. The earliest clinical applications demonstrated both conditioned suppression and enhancement of immune processes. Read More

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http://dx.doi.org/10.1016/j.jemermed.2020.04.025DOI Listing

Psychiatric Management of Bariatric Surgery Patients: A Review of Psychopharmacological and Psychological Treatments and Their Impact on Postoperative Mental Health and Weight Outcomes.

Psychosomatics 2020 Apr 24. Epub 2020 Apr 24.

Centre for Mental Health, University Health Network, Toronto, ON, Canada; Bariatric Surgery Program, Toronto Western Hospital, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Background: Bariatric surgery is an effective treatment for severe obesity; however, high rates of psychiatric comorbidity complicate bariatric surgery care. As a result, importance has been placed on the need for ongoing psychiatric support in patients undergoing bariatric surgery. Given the lack of conclusive presurgery psychosocial predictors of postoperative mental health outcomes, studies have now shifted their focus to understand the long-term psychosocial sequalae that arise after surgery. Read More

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http://dx.doi.org/10.1016/j.psym.2020.04.011DOI Listing

The influence of stress and early life adversity on addiction: Psychobiological mechanisms of risk and resilience.

Authors:
Mustafa al'Absi

Int Rev Neurobiol 2020 4;152:71-100. Epub 2020 May 4.

Department of Family Medicine and Biobehavioral Health, University of Minnesota Medical School, Duluth, MN, United States. Electronic address:

Preclinical, clinical, and population research demonstrates that stress and early life adversity (ELA) increase vulnerability to initiate, maintain, and relapse in addiction. Individuals with addiction problems have higher prevalence of trauma exposure than nondrug users; and this association extends to young populations (e.g. Read More

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http://dx.doi.org/10.1016/bs.irn.2020.03.012DOI Listing

Effectiveness of a culturally adapted cognitive behavioural therapy-based guided self-help (CACBT-GSH) intervention to reduce social anxiety and enhance self-esteem in adolescents: a randomized controlled trial from Pakistan.

Behav Cogn Psychother 2020 May 26:1-12. Epub 2020 May 26.

Department of Mental Health, Psychiatry & Behavioural Sciences, Peshawar Medical College, Riphah International University, Islamabad, Pakistan.

Background: Social anxiety is common among adolescents in Pakistan and is associated with low self-esteem. Among the recommended treatments, cognitive behavioural therapy (CBT) is effective, and self-help approaches are encouraged.

Aim: To determine the effectiveness of culturally adapted CBT-based guided self-help (CACBT-GSH) intervention, using a manual 'Khushi aur Khatoon', for treating social anxiety when added to treatment as usual (TAU) compared with TAU only. Read More

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http://dx.doi.org/10.1017/S1352465820000284DOI Listing

Primary outcome reporting in adolescent depression clinical trials needs standardization.

BMC Med Res Methodol 2020 May 25;20(1):129. Epub 2020 May 25.

Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, 686 Bay Street, Room 11.9712, Toronto, Ontario, M5G 0A4, Canada.

Background: Evidence-based health care is informed by results of randomized clinical trials (RCTs) and their syntheses in meta-analyses. When the trial outcomes measured are not clearly described in trial publications, knowledge synthesis, translation, and decision-making may be impeded. While heterogeneity in outcomes measured in adolescent major depressive disorder (MDD) RCTs has been described, the comprehensiveness of outcome reporting is unknown. Read More

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http://dx.doi.org/10.1186/s12874-020-01019-6DOI Listing

Chronic Pain in HIV.

Mol Pain 2020 Jan-Dec;16:1744806920927276

Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

The evolution of therapeutics for and management of human immunodeficiency virus-1 (HIV-1) infection has shifted it from predominately manifesting as a severe, acute disease with high mortality to a chronic, controlled infection with a near typical life expectancy. However, despite extensive use of highly active antiretroviral therapy, the prevalence of chronic widespread pain in people with HIV remains high even in those with a low viral load and high CD4 count. Chronic widespread pain is a common comorbidity of HIV infection and is associated with decreased quality of life and a high rate of disability. Read More

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http://dx.doi.org/10.1177/1744806920927276DOI Listing

The vagus nerve mediates the suppressing effects of peripherally administered oxytocin on methamphetamine self-administration and seeking in rats.

Neuropsychopharmacology 2020 May 25. Epub 2020 May 25.

Centre for Emotional Health, Department of Psychology, Macquarie University, Marsfield, NSW, Australia.

The neuropeptide oxytocin has emerged as a promising pharmacotherapy for methamphetamine (METH) addiction, and clinical trials of intranasal oxytocin are underway. However, there is debate as to how peripherally administered oxytocin alters brain signalling to modulate addiction processes. Interestingly, there is evidence for functional interactions between peripheral oxytocin administration and the vagus nerve. Read More

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http://dx.doi.org/10.1038/s41386-020-0719-7DOI Listing

Dental health care workers' attitude towards patients with substance use disorders in medically assisted rehabilitation (MAR).

Acta Odontol Scand 2020 May 25:1-6. Epub 2020 May 25.

Department of Addiction Medicine, Haukeland University Hospital, Bergen, Norway.

To assess knowledge, beliefs and attitudes related to treatment of MAR patients among dentists and dental hygienists. Secondly, to investigate to what extent dental health care professionals' attitudes associate with their treatment experience and beliefs regarding MAR patients. We conducted a cross-sectional study, involving a census of dental hygienists and dentists in the public dental health care services in Hordaland and Rogaland counties in Norway. Read More

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http://dx.doi.org/10.1080/00016357.2020.1769856DOI Listing

Effectiveness of Group Cognitive Behavioral Therapy and Exercise in the Management of Major Depressive Disorder: Protocol for a Pilot Randomized Controlled Trial.

JMIR Res Protoc 2020 May 25;9(5):e14309. Epub 2020 May 25.

Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

Background: Despite evidence in scientific literature indicating the effectiveness of both cognitive behavioral therapy (CBT) and physical exercise in the management of major depressive disorder (MDD), few studies have directly compared them.

Objective: This study aims to evaluate and compare the effectiveness of group CBT, physical exercise, and only wait-listing to receive treatment-as-usual (TAU) in the management of MDD. The investigators hypothesize that participants with MDD assigned to the group CBT or exercise arms of the study will achieve superior outcomes compared with participants wait-listed to receive TAU only. Read More

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http://dx.doi.org/10.2196/14309DOI Listing

The impact of medical school education on the opioid overdose crisis with concurrent training in naloxone administration and MAT.

J Addict Dis 2020 May 25:1-4. Epub 2020 May 25.

OMS III Pacific Northwest University of Health Sciences, College of Osteopathic Medicine, Yakima, WA, USA.

The Student Osteopathic Medical Association (SOMA) Overdose Prevention Task Force (OPTF) was created with a vision to reduce overdose deaths around the country through osteopathic medical student action and advocacy. With the medical understanding that opioid overdose is a public health crisis and that there are knowledge deficits within patient populations subject to possible overdose and use disorders, our aim is to increase medical education and training within the medical community, starting at the medical student level. Our focus at this time is to create training and distribution programs for naloxone, to advocate for effective Good Samaritan Laws in states where they are lacking, and to increase access to medication-assisted treatments (MAT) in the communities that need them most. Read More

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http://dx.doi.org/10.1080/10550887.2020.1762030DOI Listing

Challenges and Opportunities in Insomnia Disorder.

Int J Neurosci 2020 May 23:1-12. Epub 2020 May 23.

Ursinus College, Collegeville, PA, USA.

Insomnia disorder is a prevalent, often unrecognized condition that affects millions. This clinical disorder is characterized by difficulty initiating or maintaining sleep over a sustained period. In fact, insomnia disorder affects much more than sleep; it increases the risk for developing serious medical and psychiatric comorbidities and can exacerbate existing conditions. Read More

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http://dx.doi.org/10.1080/00207454.2020.1773460DOI Listing

Long-term effectiveness of web-based cognitive behavioral therapy for patients with eating disorders.

Eat Weight Disord 2020 May 24. Epub 2020 May 24.

Medical School Twente, Medisch Spectrum Twente, Enschede, The Netherlands.

Purpose: To evaluate the long-term effectiveness of a web-based therapist-delivered cognitive behavioral therapy (CBT) for patients with eating disorders (ED).

Methods: We used follow-up data from a randomized controlled trial that evaluated a web-based CBT on ED psychopathology and related health, compared to a waiting list control (WL) condition. As participants of the WL condition started the intervention after their waiting period, follow-up data included participants from both groups. Read More

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http://dx.doi.org/10.1007/s40519-020-00929-0DOI Listing

Improving insight to facilitate antipsychotic medication adherence in patients with schizophrenia.

Clin Neurophysiol 2020 May 11. Epub 2020 May 11.

Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2020.05.004DOI Listing

Opioid Use Disorder Treatment Facilities With Programs for Special Populations.

Am J Prev Med 2020 May 21. Epub 2020 May 21.

Center for Opioid Epidemiology and Policy, Department of Population Health, New York University School of Medicine, New York, New York.

Introduction: Special populations, including veterans, pregnant and postpartum women, and adolescents, benefit from opioid use disorder treatment tailored to their specific needs, but access to such services is poorly described. This study identifies the availability of opioid use disorder treatment facilities that use medications and have special programming and contextualizes facilities amid counties' opioid-related overdose mortality.

Methods: Data were compiled on 15,945 U. Read More

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http://dx.doi.org/10.1016/j.amepre.2020.03.022DOI Listing

One size doesn't fit all: a thematic analysis of interviews with people who have stopped participating in Narcotics Anonymous in Norway.

Addict Sci Clin Pract 2020 May 24;15(1):18. Epub 2020 May 24.

Addiction Unit, Sørlandet Hospital HF, Po. Box 416, 4604, Kristiansand, Norway.

Background: For persons with substance use disorders (SUDs), 12-step groups (TSGs) are the most available and used peer-based recovery resource, worldwide. However, disengagement is common, and attrition may partly be due to practices and procedures within these groups that are unacceptable to a portion of the population with SUDs. Our overall aim was to identify problematic issues related to Narcotics Anonymous (NA) participation in Norway, to inform addiction professionals' strategies when referring persons to addiction-related self-help groups (SHGs). Read More

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http://dx.doi.org/10.1186/s13722-020-00191-wDOI Listing

Prisoners should not be left behind in HCV research and policies.

Harm Reduct J 2020 May 24;17(1):33. Epub 2020 May 24.

Heidelberg Institute of Global Health, Heidelberg University, Bergheimer Str. 20, Zimmer 317, 69115, Heidelberg, Germany.

With a worldwide prevalence of 15.4%, hepatitis C virus (HCV) has been estimated to be the most prevalent major infectious disease in prisons. The exceptionally high prevalence of HCV in prisons is attributable to common risk behaviors including sharing contaminated tattooing equipment and drug paraphernalia, as well as lack of HCV control interventions including needle and syringe programs. Read More

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http://dx.doi.org/10.1186/s12954-020-00379-yDOI Listing

Cognitive behavioral group therapy for panic disorder in a general clinical setting: a prospective cohort study with 12 to 31-years follow-up.

BMC Psychiatry 2020 May 24;20(1):259. Epub 2020 May 24.

Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

Background: The long-term prognosis after cognitive behavioral therapy (CBT) in outpatient groups for panic disorder and agoraphobia is not well known. The purpose of this study was to assess long-term outcomes in terms of psychological health, health-related quality of life (HRQoL), quality of life (QoL) and treatment satisfaction after CBT for panic disorder and agoraphobia.

Methods: The sample consisted of 68 patients (61% response rate), who were assessed at pretreatment; at the start and end of treatment; and after 3 months, after 1 year, and over the long term (M = 24 years; SD = 5. Read More

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http://dx.doi.org/10.1186/s12888-020-02679-wDOI Listing

Immediate versus wait-and-gradual discontinuation in antipsychotic switching: A meta-analysis.

J Psychopharmacol 2020 May 25:269881120922964. Epub 2020 May 25.

Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, Canada.

Introduction: In two previous meta-analyses of randomized controlled trials (RCTs) examining antipsychotic switching strategies in patients with schizophrenia, we showed no significant differences in any clinical outcomes between immediate versus gradual and gradual versus wait-and-gradual discontinuation of the pre-switch antipsychotic. In this report, we compared immediate versus wait-and-gradual antipsychotic discontinuation.

Methods: We identified five RCTs examining immediate versus wait-and-gradual discontinuation of the pre-switch antipsychotic in antipsychotic switching involving patients with schizophrenia. Read More

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http://dx.doi.org/10.1177/0269881120922964DOI Listing

Time to revisit uneven policy in the US for medication for opioid use disorder during Covid19.

Addiction 2020 May 24. Epub 2020 May 24.

Addiction Psychiatry Fellow, Boston Medical Center/VA Boston Healthcare System, 720 Harrison Avenue, 7th Floor, Suite 7600, Boston, MA, 02118, USA.

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http://dx.doi.org/10.1111/add.15143DOI Listing

Core competencies for Australian pharmacists when supplying prescribed opioids: a modified Delphi study.

Int J Clin Pharm 2020 May 23. Epub 2020 May 23.

Department of Pharmacy and Biomedical Science, College of Science, Health and Engineering, La Trobe University, PO Box 199, Bendigo, VIC, 3552, Australia.

Background In the past decade, there has been an increase in prescription opioid related harms. These include dependence, non-fatal and fatal overdose. Pharmacists play a an important role in safe opioid supply. Read More

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http://dx.doi.org/10.1007/s11096-020-01060-xDOI Listing

TP63 links chromatin remodeling and enhancer reprogramming to epidermal differentiation and squamous cell carcinoma development.

Cell Mol Life Sci 2020 May 23. Epub 2020 May 23.

NHC Key Laboratory of Carcinogenesis, Hunan Provincial Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.

Squamous cell carcinoma (SCC) is an aggressive malignancy that can originate from various organs. TP63 is a master regulator that plays an essential role in epidermal differentiation. It is also a lineage-dependent oncogene in SCC. Read More

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http://dx.doi.org/10.1007/s00018-020-03539-2DOI Listing

Relationship of maternal high-fat diet during pregnancy and lactation to offspring health.

Nutr Rev 2020 May 23. Epub 2020 May 23.

Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.

A balanced maternal diet is essential for proper fetal development, and the consumption of a nutritionally inadequate diet during intrauterine development and early childhood is associated with a significantly increased risk of metabolic and brain disorders in offspring. The current literature indicates that maternal exposure to a high-fat diet exerts an irreversible influence on the general health of the offspring. This review of preclinical research examines the relationship between a maternal high-fat diet during pregnancy or lactation and metabolic changes, molecular alterations in the brain, and behavioral disorders in offspring. Read More

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http://dx.doi.org/10.1093/nutrit/nuaa020DOI Listing

Association between opioid agonist therapy and testing, treatment uptake, and treatment outcomes for hepatitis C infection among people who inject drugs: A systematic review and meta-analysis.

Clin Infect Dis 2020 May 24. Epub 2020 May 24.

The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia.

Background: People who inject drugs (PWID) experience barriers to accessing testing and treatment for hepatitis C virus (HCV) infection. Opioid agonist therapy (OAT) may provide an opportunity to improve access to HCV care. This systematic review assessed the association of OAT and HCV testing, treatment, and treatment outcomes among PWID. Read More

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http://dx.doi.org/10.1093/cid/ciaa612DOI Listing

Exposure to JUUL use: cue reactivity effects in young adult current and former smokers.

Tob Control 2020 May 23. Epub 2020 May 23.

Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA

Background: Exposure to the use of first, second and third generations of electronic cigarettes (e-cigarettes) elicits the desire to vape and smoke among observers, as well as facilitates smoking behaviour. Given the rapid rise in the popularity of the pod mod JUUL, we examined whether observing the use of this device would elicit similar responses in smokers. Exploratory analyses were also conducted to determine whether JUUL can act as a smoking cue for former smokers. Read More

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http://dx.doi.org/10.1136/tobaccocontrol-2019-055553DOI Listing

Stigmatization of opioid addiction based on prescription, sex and age.

Addict Behav 2020 May 19;108:106469. Epub 2020 May 19.

California State University Los Angeles, 5151 State University Dr., Los Angeles, CA 90032, United States. Electronic address:

With opioid abuse becoming a nationwide epidemic, it is important to understand what is contributing to societal views of opioid dependence. Difference in stigmatization of drug users may exist between sexes, ages and type of drugs being used. Social perceptions may impact drug use and recovery. Read More

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http://dx.doi.org/10.1016/j.addbeh.2020.106469DOI Listing

Mediating effect of neuroticism and negative coping style in relation to childhood psychological maltreatment and smartphone addiction among college students in China.

Child Abuse Negl 2020 May 19;106:104531. Epub 2020 May 19.

School of Marxism, University of Science and Technology Liaoning, Anshan 114051, Liaoning Province, China. Electronic address:

Background: Smartphones are convenient for college students. However, overuse of smartphone or smartphone addiction, can lead to problems related to healthy development. The cause of smartphone addiction can be traced to adverse childhood experiences such as childhood psychological maltreatment. Read More

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http://dx.doi.org/10.1016/j.chiabu.2020.104531DOI Listing

The association between exposure to second-hand smoke and sleep disturbances: A systematic review and meta-analysis.

Sleep Health 2020 May 20. Epub 2020 May 20.

Department of Public Health, Dalla Lana School of Public Health, University of Toronto, Canada; Ontario Tobacco Research Unit (OTRU), Toronto, Canada.

Objective: To investigate the association between second-hand smoke (SHS) exposure and sleep disturbances by systematically reviewing the literature base and to quantify this association by conducting a meta-analysis.

Method: We did a systematic search of five databases- PubMed, Embase, CINAHL Plus, Web of Science - Core Collection, and Google Scholar. The primary outcomes were short sleep duration (SSD), poor sleep quality (PSQ), and excessive daytime sleepiness (EDS). Read More

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http://dx.doi.org/10.1016/j.sleh.2020.03.008DOI Listing

Adolescents' Intense and Problematic Social Media Use and Their Well-Being in 29 Countries.

J Adolesc Health 2020 Jun;66(6S):S89-S99

Department of Interdisciplinary Social Science, Utrecht University, Utrecht, The Netherlands.

Purpose: This study examined (1) whether intense and problematic social media use (SMU) were independently associated with adolescent well-being; (2) whether these associations varied by the country-level prevalence of intense and problematic SMU; and (3) whether differences in the country-level prevalence of intense and problematic SMU were related to differences in mobile Internet access.

Methods: Individual-level data came from 154,981 adolescents (mean = 13.5) from 29 countries that participated in the 2017/2018 Health Behaviour in School-aged Children (HBSC) survey. Read More

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http://dx.doi.org/10.1016/j.jadohealth.2020.02.014DOI Listing

High Doses of Drugs Extensively Metabolized by CYP3A4 Were Needed to Reach Therapeutic Concentrations in Two Patients Taking Inducers.

Rev Colomb Psiquiatr 2020 Apr - Jun;49(2):84-95. Epub 2018 Sep 2.

University of Kentucky Mental Health Research Center, Eastern State Hospital, Lexington, Kentucky, USA; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Álava, Spain. Electronic address:

Introduction: In the last 20 years of clinical practice, the senior author has identified these 2 rare cases in which the patients needed extremely high doses of drugs metabolized by CYP3A4 to reach and maintain serum therapeutic concentrations.

Methods: The high metabolic ability of these 2 patients was demonstrated by the low concentration-to-dose ratios (C/D ratios) of several drugs metabolized by CYP3A4.

Results: Case 1 was characterized by a history of high carbamazepine doses (up to 2,000mg/day) and needed 170 mg/day of diazepam in 2 days to cooperate with dental cleaning. Read More

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http://dx.doi.org/10.1016/j.rcp.2018.07.002DOI Listing
September 2018

Tackling the overdose crisis: The role of safe supply.

Int J Drug Policy 2020 May 1;80:102769. Epub 2020 May 1.

Department of Medicine, University of British Columbia, 317 - 2194 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada; British Columbia Centre on Substance Use, 1045 Howe St Suite 400, Vancouver, BC, V6Z 2A9, Canada; General Internal Medicine, Yale School of Medicine, 367 Cedar St, New Haven, CA 06510, United States; Program in Addiction Medicine, Yale School of Medicine, 367 Cedar St, New Haven, CA 06510, United States.

North America is experiencing an unprecedented overdose crisis driven by the proliferation of fentanyl and its analogues in the illicit drug supply. In 2018 there were 67,367 drug overdose deaths in the United States, and since 2016, there have been more than 14,700 overdose deaths in Canada, with most related to fentanyl. Despite concerted efforts and some positive progress, current public health, substance use treatment, and harm reduction interventions (such as widespread naloxone distribution and implementation of supervised consumption sites) have not been able to rapidly decrease overdose fatalities. Read More

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http://dx.doi.org/10.1016/j.drugpo.2020.102769DOI Listing