Pharmacokinetics of concentrated naloxone nasal spray for opioid overdose reversal: Phase I healthy volunteer study.
- Rebecca McDonald,
- Ulrike Lorch,
- Jo Woodward,
- Björn Bosse,
- Helen Dooner,
- Gill Mundin,
- Kevin Smith,
- John Strang
Addiction 2017 Nov 16. Epub 2017 Nov 16.
National Addiction Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Background And Aims: Take-home naloxone can prevent death from heroin/opioid overdose, but pre-provision is difficult because naloxone is usually given by injection. Non-injectable alternatives, including naloxone nasal sprays, are currently being developed. To be effective, the intranasal (i. Read More