349,312 results match your criteria Acute medicine & surgery[Journal]


Stroke care during the Covid-19 pandemic: Experience from three large European countries.

Eur J Neurol 2020 Jun 3. Epub 2020 Jun 3.

Stroke and Dementia Lab, "Luigi Sacco" Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.

To cope with the exponentially increasing number of patients infected by SARS-Cov-2, European countries carried out enormous efforts to reorganize medical assistance, and several diseases, including stroke, were particularly impacted. Herein, we report the experience of stroke neurologists from three European countries, Italy, France and Germany, that faced the pandemic at diverse time points and with different approaches, depending on their resources and health care system organization. Pre-hospital and in-hospital acute stroke pathways were reorganized to prioritize COVID-19 management, and, in severely affected regions of Italy and France, stroke care was centralized to a limited number of centers while remaining stroke units were dedicated to COVID-19 patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ene.14375DOI Listing

Prevention of Venous Thromboembolism in Hospitalized Medically Ill Patients: A U.S. Perspective.

Thromb Haemost 2020 Jun 3;120(6):924-936. Epub 2020 Jun 3.

University of Oklahoma Health Sciences Center, Hudson College of Public Health, Oklahoma City, Oklahoma, United States.

Venous thromboembolism (VTE) remains a major cause of morbidity and mortality in hospitalized medically ill patients. These patients constitute a heterogeneous population, whose VTE risk is dependent upon the acute medical illness, immobility status, and patient-specific risk factors that have been incorporated into individualized VTE risk assessment models. Randomized placebo-controlled trials (RCTs) have shown both efficacy and net clinical benefit of in-hospital thromboprophylaxis, which is supported by guideline recommendations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0040-1710326DOI Listing

Treatment of Venous Thromboembolism in Special Populations with Direct Oral Anticoagulants.

Thromb Haemost 2020 Jun 3;120(6):899-911. Epub 2020 Jun 3.

Section of Angiology, Center of Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Germany.

As a result of the successful completion of their respective phase III studies compared with vitamin K antagonists (VKAs), four direct oral anticoagulants (DOACs) have been approved for the treatment and secondary prevention of venous thromboembolism (VTE). These DOACs-apixaban, dabigatran, edoxaban, and rivaroxaban-have subsequently seen a steady uptake among clinicians since their approval. Despite the suitability of DOACs for a broad range of patients, they are not appropriate in certain situations, whereas in others they require additional considerations such as dose reductions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0040-1710314DOI Listing

COVID-19 Pandemic and Role of Human Saliva as a Testing Biofluid in Point-of-Care Technology.

Eur J Dent 2020 Jun 3. Epub 2020 Jun 3.

Department of Biomedical Engineering, College of Engineering, King Faisal University, Al Ahsa, Saudi Arabia.

Novel coronavirus disease 2019 (COVID-19) outbreak has termed as a controllable pandemic, and the entire world has come to a standstill trying to mitigate the disease with health systems. Health care providers, around the globe, are fighting day and night. Currently, rapid testing is taking place with the help of nasopharyngeal, oropharyngeal swab, bronchoalveolar lavage, sputum, urine, and blood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0040-1713020DOI Listing

Moderate-intensity exercise and high-intensity interval training affect insulin sensitivity similarly in obese adults.

J Clin Endocrinol Metab 2020 Jun 3. Epub 2020 Jun 3.

Substrate Metabolism Laboratory, School of Kinesiology, University of Michigan, USA.

Objective: We compared the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on insulin sensitivity and other important metabolic adaptations in adults with obesity.

Methods: Thirty-one inactive adults with obesity (age: 31±6 years, BMI: 33±3 kg/m2) completed 12 weeks (4 sessions/week) of either HIIT (10x1-minute at 90%HRmax, 1-minute active recovery; n=16) or MICT (45 minutes at 70%HRmax; n=15). To assess the direct effects of exercise independent of weight/fat loss, participants were required to maintain body mass. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/clinem/dgaa345DOI Listing

Necroptosis inhibition prevents long-term cardiac damage during pneumococcal pneumonia and invasive disease.

J Infect Dis 2020 Jun 3. Epub 2020 Jun 3.

Department of Microbiology, The University of Alabama at Birmingham, Birmingham, USA.

Background: Streptococcus pneumoniae (Spn) infection can result in bacteremia with devastating consequences including heart damage. Necroptosis is a pro-inflammatory form of cell death instigated by pore-forming toxins such as Spn pneumolysin. Necroptosis-inhibiting drugs may lessen organ damage during invasive pneumococcal disease (IPD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/infdis/jiaa295DOI Listing

Acute Kidney Injury Caused by TAFRO Syndrome in a Chinese Patient: Efficacy of Long-Term Corticosteroids Combined with Bortezomib and Cyclophosphamide.

Kidney Blood Press Res 2020 Jun 3:1-7. Epub 2020 Jun 3.

Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China,

Introduction: Thrombocytopenia, ascites, myelofibrosis, renal dysfunction, and organomegaly (TAFRO) syndrome is a newly recognized and rare clinical subtype of Castleman disease. Renal involvement in TAFRO syndrome usually presents with mild proteinuria, microscopic hematuria, and acute renal injury requiring temporary renal replacement. There is no standard therapy available and treatment failures are common, leading to a poor prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000505458DOI Listing

miR-195-5p alleviates acute kidney injury through repression of inflammation and oxidative stress by targeting vascular endothelial growth factor A.

Aging (Albany NY) 2020 Jun 3;12. Epub 2020 Jun 3.

Department of Nephrology, Huai'an Second People's Hospital and The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.

Acute kidney injury (AKI) is a common renal dysfunction. Renal ischemia-reperfusion (I/R) injury contributes to AKI progression. The microRNA miR-195-5p can act as a crucial tumor inhibitor in various cancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103160DOI Listing

Emodin attenuates acute lung injury in Cecal-ligation and puncture rats.

Int Immunopharmacol 2020 May 31;85:106626. Epub 2020 May 31.

Department of Emergency, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

Acute lung injury (ALI) is a major cause of sepsis-induced acute respiratory failure. Emodin has been considered to play a protective role for acute lung edema in cecal ligation and puncture (CLP)-induced sepsis model. In this study we aimed to investigate whether emodin could improve CLP-induced lung sepsis via regulating aquaporin (AQP) and tight junction (TJ), inflammatory factors, and pulmonary apoptosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2020.106626DOI Listing

Recurrent Cerebral Vasospasm and Delayed Cerebral Ischemia Weeks Subsequent to Elective Clipping of an Unruptured Middle Cerebral Artery Aneurysm.

World Neurosurg 2020 May 31. Epub 2020 May 31.

Carilion Clinic, Section of Neurosurgery, 1906 Belleview Ave, Roanoke, VA 24014, USA; Virginia Tech Carilion School of Medicine, 2 Riverside Circle, Roanoke, VA 24016, USA; Virginia Tech School of Neuroscience, 300 Turner Street NW, Blacksburg, VA 24061, USA.

Background: Cerebral vasospasm and delayed ischemic neurologic deficits are well-known clinical after-effects of subarachnoid hemorrhage due to rupture of an intracranial aneurysm. However, vasospasm with consequential ischemia following clipping of an unruptured aneurysm is an exceedingly rare sequelae encountered in the neurosurgical literature.

Case Description: A 53-year-old female presented for elective craniotomy with microsurgical clipping of an unruptured left middle cerebral artery bifurcation saccular aneurysm, which was successfully treated without complication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2020.05.235DOI Listing

Risks, Benefits, and Effects on Management for Biopsy of the Papilla in Patients with Familial Adenomatous Polyposis.

Clin Gastroenterol Hepatol 2020 May 31. Epub 2020 May 31.

Department of Gastroenterology, Hepatology, and Nutrition, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, United States. Sanford R. Weiss, MD Center for Hereditary Colorectal Neoplasia, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, United States.

Background & Aims: Ampullary and duodenal cancer are the leading causes of death in patients with familial adenomatous polyposis (FAP) after colectomy has been performed. Risk of duodenal cancer is determined based on Spigelman stage (SS) of duodenal polyposis. Guidelines recommend endoscopic surveillance of the duodenum and visualization of the papilla to stage duodenal polyposis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cgh.2020.05.054DOI Listing

Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells.

Cell Rep 2020 Jun;31(9):107688

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

Leukemia stem cells (LSCs) are believed to have more distinct vulnerabilities than the bulk acute myeloid leukemia (AML) cells, but their rarity and the lack of universal markers for their prospective isolation hamper their study. We report that genetically clonal induced pluripotent stem cells (iPSCs) derived from an AML patient and characterized by exceptionally high engraftment potential give rise, upon hematopoietic differentiation, to a phenotypic hierarchy. Through fate-tracking experiments, xenotransplantation, and single-cell transcriptomics, we identify a cell fraction (iLSC) that can be isolated prospectively by means of adherent in vitro growth that resides on the apex of this hierarchy and fulfills the hallmark features of LSCs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2020.107688DOI Listing

Oral Anticoagulants and Antiplatelet Agents in Patients With Atrial Fibrillation and Concomitant Critical Limb Ischemia: A Nationwide Cohort Study.

Can J Cardiol 2020 Feb 19. Epub 2020 Feb 19.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom.

Background: Evidence of clinical outcomes for oral anticoagulants and antiplatelet treatment (APT) in patients with atrial fibrillation (AF) and critical limb ischemia (CLI) is very limited.

Methods: In this nationwide retrospective cohort study collected from Taiwan National Health Insurance Research Database, 1223 patients with AF and CLI taking direct-acting oral coagulants (DOACs), warfarin, or APT were identified from June 1, 2012, to December 31, 2017. We used propensity score stabilized weighting (PSSW) to balance covariates across study groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cjca.2020.02.071DOI Listing
February 2020

N-acetylcysteine differentially regulates the populations of bone marrow and circulating endothelial progenitor cells in mice with limb ischemia.

Eur J Pharmacol 2020 May 31:173233. Epub 2020 May 31.

Center for Precision Medicine and Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, MO, USA. Electronic address:

Endothelial progenitor cells (EPCs) are important to tissue repair and regeneration especially after ischemic injury, and very heterogeneous in phenotypes and biological features. Reactive oxygen species are involved in regulating EPC number and function. N-acetylcysteine (NAC) inhibits ischemia-induced reactive oxygen species formation and promotes ischemic limb recovery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2020.173233DOI Listing

Sustainability of antimicrobial stewardship programs in Australian rural hospitals: a qualitative study.

Aust Health Rev 2020 Jun;44(3):415-420

National Centre for Antimicrobial Stewardship, Peter Doherty Research Institute for Infection and Immunity, Level 5, 792 Elizabeth Street, Melbourne, Vic. 3000, Australia. Email: and Department of Medicine - Royal Melbourne Hospital, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Royal Parade, Melbourne, Vic. 3050, Australia; and Victorian Infectious Diseases Service, Royal Melbourne Hospital, 300 Grattan Street, Melbourne, Vic. 3050, Australia.

Objective The aim of this study was to explore the features of sustainable antimicrobial stewardship (AMS) programs in Australian rural hospitals and develop recommendations on incorporating these features into rural hospitals' AMS programs. Methods Lead AMS clinicians with knowledge of at least one AMS program sustained for >2 years in a health service in rural Australia were recruited to the study. A series of interviews was conducted and the transcripts analysed thematically using a framework method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1071/AH19097DOI Listing

Reply to Tuffet, et al. and Michard, et al.

Am J Respir Crit Care Med 2020 Jun 3. Epub 2020 Jun 3.

University Hospital Modena, 208968, Respiratory Diseases Unit, Modena, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.202005-1730LEDOI Listing

Rationale and Design of ORCHID: A Randomized Placebo-Controlled Trial of Hydroxychloroquine for Adults Hospitalized with COVID-19.

Ann Am Thorac Soc 2020 Jun 3. Epub 2020 Jun 3.

Vanderbilt University Medical Center, 12328, Emergency Medicine, Nashville, Tennessee, United States.

The Outcomes Related to COVID-19 treated with Hydroxychloroquine among In-patients with symptomatic Disease (ORCHID) trial is a multicenter, blinded, randomized trial of hydroxychloroquine versus placebo for the treatment of adults hospitalized with COVID-19. This document provides the rationale and background for the trial and highlights key design features. We discuss five novel challenges to the design and conduct of a large, multi-center, randomized trial during a pandemic, including: 1) widespread, off-label use of the study drug before the availability of safety and efficacy data; 2) the need to adapt traditional procedures for documentation of informed consent during an infectious pandemic; 3) developing a flexible and robust Bayesian analysis incorporating significant uncertainty about the disease, outcomes, and treatment; 4) obtaining indistinguishable drug and placebo without delaying enrollment; and 5) rapidly obtaining administrative and regulatory approvals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1513/AnnalsATS.202005-478SDDOI Listing

Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children.

N Engl J Med 2020 Jun;382(23):2207-2219

From the Departments of Pediatric and Adolescent Oncology (V.M.-C., C.P.) and Clinical Research (G.V.), INSERM Unité 1015 (V.M.-C.), and the Unit of Biostatistics and Epidemiology and INSERM Unité 1018 (A.A.), Gustave Roussy, Université Paris-Saclay, Villejuif, France; the Department of Pediatric Hematology and Oncology, University of Padua, Padua, Italy (M.P.); the Department of Paediatric Haematology, Oncology, and Palliative Care, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge (G.A.A.B.), Cancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham (K.W.), and the Department of Histopathology, Royal Marsden NHS Foundation Trust, London (A.W.) - all in the United Kingdom; the Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles (D.A.B.); the Department of Pediatric Hematology and Oncology, University of Valencia, Valencia, Spain (R.F.D.); the Division of Haematology-Oncology, Hospital for Sick Children, Toronto (S.A.); the Department of Pediatric Hematology and Oncology, University Hospitals Leuven, Leuven, Belgium (A.U.); the Center for Cancer and Immunology Research, Children's National Health System and George Washington University, Washington, DC (C.M.B.); Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands (J.Z.); the Department of Pediatric Hematology and Oncology, Semmelweis University, Budapest, Hungary (M.C.); the Department of Pediatric Bone Marrow Transplantation, Oncology, and Hematology, Wroclaw Medical University, Wroclaw, Poland (B.K.); the Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong (A.K.C.); the Department of Pathology, University of Utah, Salt Lake City (R.R.M.); Children's Hospital of Philadelphia, Philadelphia (P.C.A.); and the National Cancer Institute, Center for Global Health, Rockville, MD (T.G.G.).

Background: Rituximab added to chemotherapy prolongs survival among adults with B-cell cancer. Data on its efficacy and safety in children with high-grade, mature B-cell non-Hodgkin's lymphoma are limited.

Methods: We conducted an open-label, international, randomized, phase 3 trial involving patients younger than 18 years of age with high-risk, mature B-cell non-Hodgkin's lymphoma (stage III with an elevated lactate dehydrogenase level or stage IV) or acute leukemia to compare the addition of six doses of rituximab to standard lymphomes malins B (LMB) chemotherapy with standard LMB chemotherapy alone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1915315DOI Listing

A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19.

N Engl J Med 2020 Jun 3. Epub 2020 Jun 3.

From the University of Minnesota (D.R.B., M.F.P., A.S.B., K.A.P., S.M.L., E.C.O., C.P.S., A.A.N., M.R.N., M.A., N.W.E., R.R., K.H.H.) and M Health Fairview Investigational Drug Service Pharmacy (D.L.), Minneapolis; and the Research Institute of the McGill University Health Centre and the Clinical Practice Assessment Unit, Department of Medicine, McGill University, Montreal (M.P.C., E.G.M., T.C.L.), the Department of Internal Medicine, University of Manitoba (S.A.L., L.J.M., G.D., N.M., R.Z.), the Research Institute in Oncology and Hematology, CancerCare Manitoba, University of Manitoba (R.Z.), and the George and Fay Yee Centre for Healthcare Innovation (L.E.K.), Winnipeg, and the University of Alberta, Edmonton (I.S.S.) - all in Canada.

Background: Coronavirus disease 2019 (Covid-19) occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For persons who are exposed, the standard of care is observation and quarantine. Whether hydroxychloroquine can prevent symptomatic infection after SARS-CoV-2 exposure is unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa2016638DOI Listing

Two hits to the renin-angiotensin system may play a key role in severe COVID-19.

Kaohsiung J Med Sci 2020 Jun 3. Epub 2020 Jun 3.

Department of Medicine, Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, USA.

The spike glycoprotein on the virion surface docking onto the angiotensin-converting enzyme (ACE) 2 dimer is an essential step in the process of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in human cells-involves downregulation of ACE2 expression with systemic renin-angiotensin system (RAS) imbalance and promotion of multi-organ damage. In general, the RAS induces vasoconstriction, hypertension, inflammation, fibrosis, and proliferation via the ACE/Ang II/Ang II type 1 receptor (AT1R) axis and induces the opposite effects via the ACE2/Ang (1-7)/Mas axis. The RAS may be activated by chronic inflammation in hypertension, diabetes, obesity, and cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/kjm2.12237DOI Listing

CAG regimen for refractory or relapsed adult T-cell acute lymphoblastic leukemia: A retrospective, multicenter, cohort study.

Cancer Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Hematology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.

Adult patients with relapsed or refractory T-cell acute lymphoblastic leukemia (R/R-T-ALL) have extremely poor prognosis, representing an urgent unmet medical need. Finding an optimal salvage regimen to bridge transplantation is a priority. The CAG (cytarabine, aclarubicin, and G-CSF) regimen was initially used by one group in China, showing unexpectedly promising results in 11 R/R-T-ALL patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cam4.3079DOI Listing

Impact of Respiratory Viral Polymerase Chain Reaction Testing on De-escalation of Antibiotic Therapy in Children who Require Chronic Positive Pressure Ventilation.

Pediatr Pulmonol 2020 Jun 3. Epub 2020 Jun 3.

Hospital Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, U.S.A.

Background: Children who require chronic positive pressure ventilation (CPPV) are frequently hospitalized with acute respiratory infections (ARI). Although respiratory viral testing is often performed, it is unclear how positive results impact antibiotic use. We sought to assess the impact of respiratory viral testing on antibiotic use in hospitalized children on CPPV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24884DOI Listing

The epidemiology of kicking injuries in professional Rugby Union: a 15-season prospective study.

Scand J Med Sci Sports 2020 Jun 3. Epub 2020 Jun 3.

Applied Sports, Technology, Exercise and Medicine Research Centre, Swansea University, Swansea, UK.

Purpose: Whilst kicking in Rugby Union can be influential to match outcome, the epidemiology of kicking injuries remains unknown. This study therefore aimed to investigate the epidemiology of injuries attributed to kicking in professional rugby, including playing position-specific effects and differences in kicking volumes and kick types.

Methods: Fifteen seasons of injury surveillance data and two seasons of match kicking characteristics from professional rugby players were analysed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/sms.13737DOI Listing

Structural variations and expression profiles of the SARS-CoV-2 host invasion genes in Lung cancer.

J Med Virol 2020 Jun 3. Epub 2020 Jun 3.

Nigde Omer Halisdemir University, Faculty of Medicine, Department of Medical Biology, Nigde, Turkey.

Recent days have seen growing evidence of cancer's susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and of the effect of genomic differences on the virus' entrance genes in lung cancer. Genetic confirmation of the hypotheses regarding gene expression and mutation pattern of target genes, including Angiotensin Converting Enzyme-2 (ACE2), Transmembrane Serine Protease 2 (TMPRSS2), Basigin (CD147/BSG) and Paired Basic Amino Acid Cleaving Enzyme (FURIN/PCSK3), as well as correlation analysis, were evaluated in lung adenocarcinoma (LUAD) and lung squamous carcinoma (LUSC) using in silico analysis. Not only were gene expression and mutation patterns detected, but also there was a correlation and survival analysis between ACE2 and other target genes expression levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jmv.26107DOI Listing

SARS-CoV-2: A comprehensive review from pathogenicity of the virus to clinical consequences.

J Med Virol 2020 Jun 3. Epub 2020 Jun 3.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Nowadays, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused novel coronavirus disease (COVID-19) pandemic, is the worldwide challenge. The virus is highly contagious, and clinical consequences were very divers. It is estimated that if no effective action is taken, COVID-19 could plague 90% of the world's population and kill over 40 million people. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jmv.26123DOI Listing

A case of SARS-CoV-2 infection in an untreated HIV patient in Tokyo, Japan.

J Med Virol 2020 Jun 3. Epub 2020 Jun 3.

National Center for Global Health and Medicine, Disease Control and Prevention Center, Shinjuku-ku, Tokyo, Japan.

We report a 28-year-old male co-infected with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2; COVID-19) and human immunodeficiency virus (HIV). His clinical course of the COVID-19 pneumonia improved smoothly in 9 days; however, his immune status from HIV infection was not well-controlled due to a lack of antiretroviral therapy (ART). The HIV-1 viral load decreased during the acute phase and subsequently increased in the recovery phase. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jmv.26102DOI Listing

First case of acute pancreatitis related to SARS-CoV-2 infection.

Br J Surg 2020 Jun 3. Epub 2020 Jun 3.

Internal Medicine Department, Diaconesses Croix Saint Simon Hospital, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bjs.11741DOI Listing

Clinical and Immune Features of Hospitalized Pediatric Patients With Coronavirus Disease 2019 (COVID-19) in Wuhan, China.

JAMA Netw Open 2020 Jun 1;3(6):e2010895. Epub 2020 Jun 1.

Department of Laboratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Importance: The epidemiologic and clinical characteristics of pediatric patients with coronavirus disease 2019 (COVID-19) have been reported, but information on immune features associated with disease severity is scarce.

Objective: To delineate and compare the immunologic features of mild and moderate COVID-19 in pediatric patients.

Design, Setting, And Participants: This single-center case series included 157 pediatric patients admitted to Wuhan Children's Hospital with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamanetworkopen.2020.10895DOI Listing

New insights into risk factors for transplant-associated thrombotic microangiopathy in pediatric HSCT.

Blood Adv 2020 Jun;4(11):2418-2429

Department of Blood and Marrow Transplantation, Great Ormond Street (GOS) Hospital for Children NHS Foundation Trust, University College London GOS Institute of Child Health, and NIHR GOSH BRC, London, United Kingdom.

This study aimed to identify a risk profile for development of transplant-associated thrombotic microangiopathy (TA-TMA) in children undergoing hematopoietic stem cell transplantation (HSCT). Between 2013 and 2016, 439 children underwent 474 HSCTs at 2 supraregional United Kingdom centers. At a median of 153 days post-HSCT, TA-TMA occurred among 25 of 441 evaluable cases (5. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/bloodadvances.2019001315DOI Listing

Manganese-induced mitochondrial dysfunction is not detectable at exposures below the acute cytotoxic threshold in neuronal cell types.

Toxicol Sci 2020 Jun 3. Epub 2020 Jun 3.

Departments of Pediatrics and Neurology, Vanderbilt University Medical Center, Nashville, TN.

Manganese (Mn) is an essential metal, but excessive exposures have been well-documented to culminate in neurotoxicity. Curiously, the precise mechanisms of Mn neurotoxicity are still unknown. One hypothesis suggests that Mn exerts its toxicity by inhibiting mitochondrial function, which then (if exposure levels are high and long enough) leads to cell death. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/toxsci/kfaa079DOI Listing

Prediction of mortality rate in acute type A dissection: the German Registry for Acute Type A Aortic Dissection score.

Eur J Cardiothorac Surg 2020 Jun 3. Epub 2020 Jun 3.

Department of Cardiovascular Surgery, University Heart Center Freiburg, Bad Krozingen, Germany.

Objectives: The goal was to develop a scoring system to predict the 30-day mortality rate for patients undergoing surgery for acute type A aortic dissection on the basis of the German Registry for Acute Type A Aortic Dissection (GERAADA) data set and to provide a Web-based application for standard use.

Methods: A total of 2537 patients enrolled in GERAADA who underwent surgery between 2006 and 2015 were analysed. Variable selection was performed using the R-package FAMoS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ejcts/ezaa156DOI Listing

COVID-19 pandemic: Impact caused by school closure and national lockdown on pediatric visits and admissions for viral and non-viral infections, a time series analysis.

Clin Infect Dis 2020 Jun 3. Epub 2020 Jun 3.

Assistance Publique-Hôpitaux de Paris, Department of Clinical Microbiology, Necker-Enfants Malades University Hospital, Université de Paris, Paris, France.

A time series analysis of 871,543 pediatric emergency visits revealed that the COVID-19 lockdown and school closure were associated with a significant decrease in infectious diseases disseminated through airborne or fecal-oral transmissions: common cold, gastro-enteritis, bronchiolitis, acute otitis. No change was found for urinary tract infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciaa710DOI Listing

Epidemiology, Clinical Features, and Disease Severity in Patients With Coronavirus Disease 2019 (COVID-19) in a Children's Hospital in New York City, New York.

JAMA Pediatr 2020 Jun 3:e202430. Epub 2020 Jun 3.

Department of Pediatrics, Columbia University Irving Medical Center, New York, New York.

Importance: Descriptions of the coronavirus disease 2019 (COVID-19) experience in pediatrics will help inform clinical practices and infection prevention and control for pediatric facilities.

Objective: To describe the epidemiology, clinical, and laboratory features of patients with COVID-19 hospitalized at a children's hospital and to compare these parameters between patients hospitalized with and without severe disease.

Design, Setting, And Participants: This retrospective review of electronic medical records from a tertiary care academically affiliated children's hospital in New York City, New York, included hospitalized children and adolescents (≤21 years) who were tested based on suspicion for COVID-19 between March 1 to April 15, 2020, and had positive results for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamapediatrics.2020.2430DOI Listing

Risk factors for blood transfusion in traumatic and postpartum hemorrhage patients: Analysis of the CRASH-2 and WOMAN trials.

PLoS One 2020 3;15(6):e0233274. Epub 2020 Jun 3.

Department of Population Health, Clinical Trials Unit, London School of Hygiene & Tropical Medicine, London, England, United Kingdom.

Background: Hemorrhage is a leading cause of death after trauma and childbirth. In response to severe hemorrhage, bleeding patients often receive transfusions of red blood cells, plasma, platelets, or other blood components. We examined risk factors for transfusion in acute severe bleeding in two trials of over 20,000 patients to better understand factors associated with transfusion likelihood. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233274PLOS

To beer or not to beer: A meta-analysis of the effects of beer consumption on cardiovascular health.

PLoS One 2020 3;15(6):e0233619. Epub 2020 Jun 3.

Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Ospedale Civile of Baggiovara, Modena, Italy.

A moderate alcohol consumption is demonstrated to exert a protective action in terms of cardiovascular risk. Although this property seems not to be beverage-specific, the various composition of alcoholic compounds could mediate peculiar effects in vivo. The aim of this study was to evaluate potential beer-mediated effects on the cardiovascular health in humans, using a meta-analytic approach (trial registration number: CRD42018118387). Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233619PLOS

Acute malnutrition recovery energy requirements based on mid-upper arm circumference: Secondary analysis of feeding program data from 5 countries, Combined Protocol for Acute Malnutrition Study (ComPAS) Stage 1.

PLoS One 2020 3;15(6):e0230452. Epub 2020 Jun 3.

Department of Population Health & Centre for Maternal, Adolescent and Child Health (MARCH), London School of Hygiene and Tropical Medicine, London, England, United Kingdom.

Background: Severe and moderate acute malnutrition (SAM and MAM) are currently treated with different food products in separate treatment programs. The development of a unified and simplified treatment protocol using a single food product aims to increase treatment program efficiency and effectiveness. This study, the first stage of the ComPAS trial, sought to assess rate of growth and energy requirements among children recovering from acute malnutrition in order to design a simplified, MUAC-based dosage protocol. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230452PLOS

School Nurses on the Front Lines of Healthcare: Infectious Diseases Popularized in the News.

NASN Sch Nurse 2020 Jun 3:1942602X20921426. Epub 2020 Jun 3.

Professor, Departments of Emergency Medicine and Pediatrics, Penn State College of Medicine, Attending Pediatric Emergency Medicine Physician, Penn State Hershey Medical Center, Hershey, PA.

School nurses may deal with students presenting with symptoms associated with infections popularized in the news. Although rare, the implications of missing or misdiagnosing these infections are potentially life-threatening and devastating. We present three students presenting with febrile illnesses associated with neurologic symptoms, a rash, and fatigue, focusing on the initial assessment and management of these students and their associated "hot topic" infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1942602X20921426DOI Listing

Increased microvascular permeability and low level of low-density lipoprotein cholesterol predict symptomatic intracerebral hemorrhage in acute ischemic stroke.

Sci Prog 2020 Apr-Jun;103(2):36850420924153

Department of General Internal Medicine, The First Hospital of Jilin University, Changchun, China.

Symptomatic intracerebral hemorrhage is a serious potential complication of recombinant tissue-type plasminogen activator thrombolysis in acute ischemic stroke. We investigated the optimal imaging and clinical parameters to predict symptomatic intracerebral hemorrhage in acute ischemic stroke patients after recombinant tissue-type plasminogen activator therapy. We retrospectively reviewed 151 acute ischemic stroke patients with thrombolytic therapy, who were dichotomized into symptomatic intracerebral hemorrhage group and non-symptomatic intracerebral hemorrhage group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0036850420924153DOI Listing

Understanding the age divide in COVID-19: Why are children overwhelmingly spared?

Am J Physiol Lung Cell Mol Physiol 2020 Jun 3. Epub 2020 Jun 3.

Pediatric Surgery, University of Texas McGovern Medical School, United States.

The rapid emergence and subsequent global dissemination of SARS-CoV-2 Disease (COVID-19) has resulted in over 4 million cases worldwide. The disease has a marked predilection for adults, and children are relatively spared. Understanding the age-based differences in pathophysiological pathways and processes relevant to the onset and progression of disease both in the clinical course and in experimental disease models may hold the key to the identification of therapeutic targets. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00183.2020DOI Listing

Increased Yield of Gelatin Coated Therapeutic Cells Through Cholesterol Insertion.

J Biomed Mater Res A 2020 Jun 3. Epub 2020 Jun 3.

Department of Chemical and Materials Engineering, University of Kentucky, Lexington, Kentucky, USA.

Gelatin coatings are effective in increasing the retention of MSCs injected into the heart and minimizing the damage from acute myocardial infarction (AMI), but early studies suffered from low fractions of the MSCs coated with gelatin. Biotinylation of the MSC surface is a critical first step in the gelatin coating process, and in this study, we evaluated the use of biotinylated cholesterol "lipid insertion" anchors as a substitute for the covalent NHS-biotin anchors to the cell surface. Streptavidin-eosin molecules, where eosin is our photoinitiator, can then be bound to the cell surface through biotin-streptavidin affinity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.37025DOI Listing

Differences in diagnosis, treatment, and survival rate of acute myeloid leukemia with or without disabilities: A national cohort study in the Republic of Korea.

Cancer Med 2020 Jun 3. Epub 2020 Jun 3.

T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.

We analyzed the patterns of diagnosis, treatment, and prognoses of acute myeloid leukemia (AML) patients with and without disabilities. The data were collected from the National Disability Database, the Korean Central Cancer Registry, and the Korean National Health Insurance claim database. We built a cohort of 2 776 450 people with disabilities and a nondisabled cohort of 8 329 350 people who were selected at a ratio of 1:3 by matching age and sex. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cam4.3179DOI Listing