311,297 results match your criteria Acute medicine & surgery[Journal]


Lower hemoglobin levels are associated with acute seizures in patients with ruptured cerebral aneurysms.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China. Electronic address:

Objective: We test the hypothesis that low hemoglobin levels are associated with acute seizures following aneurysmal subarachnoid hemorrhage (aSAH).

Methods: Patients with ruptured intracranial aneurysms were enrolled in the observational cohort study that prospectively collected age, sex, symptom onset, history of diabetes and hypertension, history of coronary artery disease, temperature, Hunt-Hess grade, Fisher grade, aneurysm location, hemoglobin, hematocrit, serum potassium, sodium, calcium, phosphorus, iron, and modified Rankin Scale (mRS). Acute seizures were determined as seizures within one week following aSAH. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.115DOI Listing

Risk of deterioration of geriatric traumatic brain injury in patients treated with antithrombotic drugs.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

The Japan Neurotrauma Data Bank Committee, The Japan Society of Neurotraumatology, Tokyo, Japan.

Objective: Developed countries have rapidly aging populations, and use of antithrombotic drugs is increasing. We investigated the effects of antithrombotic drugs and reversal of these drugs in geriatric traumatic brain injury (TBI) patients.

Methods: Age, gender, mechanism of injury, Glasgow Coma Scale on admission, head CT findings, antithrombotic therapy, acute exacerbation, and outcomes at discharge were examined in 711 patients with geriatric TBI complicated with traumatic intracranial hemorrhage using data from the Japan Neurotrauma Data Bank Project 2015 (JNTDB P2015). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.108DOI Listing

Eight weeks of static apnea training increases spleen volume but not acute spleen contraction.

Respir Physiol Neurobiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Movement and Sports Sciences, Ghent University, Watersportlaan 2, 9000 Ghent, Belgium. Electronic address:

Splenic contraction is an important response to acute apnea causing the release of red blood cells into blood circulation. Current literature shows higher spleen volumes and greater spleen contractions in trained apnea divers compared to untrained individuals, but the influence of training is presently unknown. Thirteen subjects daily performed five static apneas for 8 weeks. Read More

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http://dx.doi.org/10.1016/j.resp.2019.04.002DOI Listing

Splenic Infarct After Warfarin Overdose Treatment; Is it coincidence or complication?

Authors:
Gökhan Yilmaz

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Specialist, Emergency Medicine Clinic, Kayseri Training and Research Hospital, Kayseri, Turkey. Electronic address:

The Splenic infarct is a rare clinical condition seen in the emergency department and can mimic acute abdomen. Hematologic, vascular and thromboembolic events are considered in the etiology. Treatment options are varying between symptomatic treatment and splenectomy. Read More

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http://dx.doi.org/10.1016/j.avsg.2019.02.012DOI Listing

A sub-chronic Xysmalobium undulatum hepatotoxicity investigation in HepG2/C3A spheroid cultures compared to an in vivo model.

J Ethnopharmacol 2019 Apr 19:111897. Epub 2019 Apr 19.

Pharmacen™, Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa; Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230, Odense M, Denmark; Celvivo IVS, Blommenslyst, Denmark. Electronic address:

Ethnopharmacology Relevance: Traditional herbal medicines are utilized by 27 million South Africans. Xysmalobium undulatum (Uzara) is one of the most widely used traditional medicinal plants in Southern Africa. A false belief in the safety of herbal medicine may result in liver injury. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111897DOI Listing

Acute Care Beta-Lactam Allergy Pathways: Approaches and Outcomes.

Ann Allergy Asthma Immunol 2019 Apr 19. Epub 2019 Apr 19.

Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA; Medical Practice Evaluation Center, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.04.009DOI Listing

The EXACT protocol: a multi-centre, single-blind, randomised, parallel-group, controlled trial to determine whether early oxygen titration improves survival to hospital discharge in adult OHCA patients.

Resuscitation 2019 Apr 19. Epub 2019 Apr 19.

Department of Epidemiology and Preventive Medicine, Monash University, Australia; Prehospital, Resuscitation and Emergency Care Research Unit, Curtin University, Australia; Alfred Hospital, Australia; Ambulance Victoria, Australia; Department of Community Emergency Health and Paramedic Practice, Monash University, Australia; SA Ambulance Service, Australia; Flinders University, Australia; St John Ambulance Western Australia, Australia; Warwick University, United Kingdom.

Background: Experimental and observational research suggests hyperoxia following resuscitation from cardiac arrest is associated with neurological injury and worse clinical outcomes. This paper describes the rationale and design of the EXACT trial. EXACT aims to determine whether reducing oxygen in the acute phase of post-resuscitation care for out-of-hospital cardiac arrest (OHCA) improves survival. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.023DOI Listing

Impella use in acute myocardial infarction complicated by cardiogenic shock and cardiac arrest : Analysis of 10 years registry data.

Resuscitation 2019 Apr 19. Epub 2019 Apr 19.

Department of Heart Disease, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Aims: To assess characteristics and outcome of patients treated with Impella for acute myocardial infarction (AMI) complicated by severe cardiogenic shock (CS) or cardiac arrest (CA).

Methods And Results: From 2008 through 2017, 92 patients with AMI complicated by CS were treated with Impella. Survival varied according to clinical presentation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03009572193013
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http://dx.doi.org/10.1016/j.resuscitation.2019.04.022DOI Listing
April 2019
2 Reads

"Platelet-rich plasma and its utility in medical dermatology - A systematic review".

J Am Acad Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Dermatology, Johns Hopkins University, Baltimore, Maryland.

The field of dermatology has seen numerous therapeutic innovations in the past decade with platelet-rich plasma (PRP) recently garnering significant interest particularly in alopecia, acne scarring and skin rejuvenation. In other conditions of dermatology, such as chronic wounds and vitiligo, PRP has been investigated but has received less attention. The objective of this literature review was to focus on conditions of medical dermatology and to consolidate the available evidence of platelet-rich plasma for the practicing dermatologist. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.04.037DOI Listing

Acute Lower Extremity Ischemia Following Thoracotomy due to Arterial Tumor Emboli.

Ann Thorac Surg 2019 Apr 19. Epub 2019 Apr 19.

New York Presbyterian Brooklyn Methodist Hospital, 506 6(th) Street, Brooklyn, NY 11215; New York Presbyterian, Weill Cornell Medicine, New York, NY.

Our patient is a 58 year old woman with metastatic uterine leiomysarcoma with prior resection found to have an isolated metastatic lesion in the upper lobe of the right lung. She underwent a thoracotomy with right upper and middle lobectomy. Following her procedure, she developed acute ischemia of her left lower extremity secondary to an embolized tumor. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975193056
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http://dx.doi.org/10.1016/j.athoracsur.2019.03.059DOI Listing
April 2019
1 Read

Co-spray-dried urea cross-linked hyaluronic acid and sodium ascorbyl phosphate as novel inhalable dry powder formulation.

J Pharm Sci 2019 Apr 19. Epub 2019 Apr 19.

Respiratory Technology, Woolcock Institute of Medical Research and Discipline of Pharmacology, Faculty of Medicine and Health, The University of Sydney, 431 Glebe Point Road, Glebe, NSW 2037, Australia. Electronic address:

The pathogenesis and progression of several lung disorders is propagated by inflammatory and oxidative processes which can be controlled by adjunctive inhaled therapies. The present study aimed to develop an inhalable dry powder formulation consisting of co-spray-dried urea-crosslinked hyaluronic acid and sodium ascorbyl phosphate (SD HA-CL - SAP), a novel combination which was recently shown to possess anti-inflammatory, antioxidant and wound healing properties. Native HA and SAP were co-spray dried (SD HA - SAP) and evaluated as control formulation. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.04.015DOI Listing
April 2019
2 Reads

Twin arginine translocation, ammonia incorporation, and polyamine biosynthesis are crucial for Proteus mirabilis fitness during bloodstream infection.

PLoS Pathog 2019 Apr 22;15(4):e1007653. Epub 2019 Apr 22.

Department of Microbiology and Immunology; University of Michigan Medical School; Ann Arbor, MI, United States of America.

The Gram-negative bacterium Proteus mirabilis is a common cause of catheter-associated urinary tract infections (CAUTI), which can progress to secondary bacteremia. While numerous studies have investigated experimental infection with P. mirabilis in the urinary tract, little is known about pathogenesis in the bloodstream. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007653DOI Listing

Spatial distribution and determinants of acute respiratory infection among under-five children in Ethiopia: Ethiopian Demographic Health Survey 2016.

PLoS One 2019 22;14(4):e0215572. Epub 2019 Apr 22.

Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Childhood acute respiratory infection remains the commonest global cause of morbidity and mortality among under-five children. In Ethiopia, it remains the highest burden of the health care system. The problem varies in space and time, and exploring its spatial distribution has supreme importance for monitoring and designing effective intervention programs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215572PLOS
April 2019
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Unreliable usage of a single influenza virus IgM antibody assay in influenza-like illness: A retrospective study of the 2016-2018 flu epidemic.

PLoS One 2019 22;14(4):e0215514. Epub 2019 Apr 22.

Department of Clinical Laboratory, Beijing Tsinghua Chang-gung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, PR. China.

We retrospectively analyzed serum IgM antibodies (Abs) to influenza viruses from two tertiary hospitals in Beijing from December 2016 to February 2018. Samples from 36,792 patients, aged 0-98 years, were collected and tested. Among the patients, 923 children from two winter flu seasons were assayed with both antigens and IgM Abs to Flu A and Flu B and assigned as paired groups. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215514PLOS

A cross-sectional survey on the seroprevalence of dengue fever in febrile patients attending health facilities in Cross River State, Nigeria.

PLoS One 2019 22;14(4):e0215143. Epub 2019 Apr 22.

Nuffield Centre for International Health and Development, University of Leeds, Leeds, United Kingdom.

Background: In Nigeria, recent reports suggest that dengue viruses could be a major cause of acute fevers. We sought to make a cross-sectional estimate of the prevalence of current and previous dengue infections in patients presenting with fever to healthcare centres in Cross River State Nigeria.

Methodology/principal Findings: This cross-sectional health facility survey recruited persons with temperature ≥38°C. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215143PLOS

Anti-interferon-α receptor 1 antibodies attenuate inflammation and organ injury following hemorrhagic shock.

J Trauma Acute Care Surg 2019 May;86(5):881-890

From the Elmezzi Graduate School of Molecular Medicine, (J.C., W-L.Y., P.W.); Center for Immunology and Inflammation, (J.C., W-L.Y., Z.W., P.W.) The Feinstein Institute for Medical Research, Manhasset; Department of Surgery, Zucker School of Medicine at Hofstra/Northwell, (W-L.Y., J.T.M., P.W.) Hempstead, New York.

Background: Hemorrhagic shock (HS) is a life-threatening condition resulting from rapid and significant loss of intravascular volume, leading to hemodynamic instability and death. Inflammation contributes to the multiple organ injury in HS. Type I interferons (IFNs), such as IFN-α and IFN-β, are a family of cytokines that regulate the inflammatory response through binding to IFN-α receptor (IFNAR) which consists of IFNAR1 and IFNAR2 chains. Read More

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http://dx.doi.org/10.1097/TA.0000000000002214DOI Listing

Risk Factors for Acute Ischemic Stroke Caused by Anterior Large Vessel Occlusion.

Stroke 2019 May;50(5):1074-1080

From the Department of Neurosurgery (P.H., N.S., O.G., C.M.S., C.J.G.), Geisinger, Danville, PA.

Background and Purpose- Accurate prediction of acute ischemic stroke (AIS) caused by anterior large vessel occlusion (LVO) that is amendable to mechanical thrombectomy remains a challenge. We developed and validated a prediction model for anterior circulation LVO stroke using past medical history elements present on admission and neurological examination. Methods- We retrospectively reviewed AIS patients admitted between 2009 and 2017 to 3 hospitals within a large healthcare system in the United States. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023917DOI Listing

Atrial Fibrillation Known Before or Detected After Stroke Share Similar Risk of Ischemic Stroke Recurrence and Death.

Stroke 2019 May;50(5):1124-1129

From the Vascular Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.-M.Y., X.-Q.Z., Y.-L.W., Z.-X.L., Y.-J.W.).

Background and Purpose- We aim to compare the risk of 1-year ischemic stroke recurrence and death for atrial fibrillation diagnosed after stroke (AFDAS), atrial fibrillation known before stroke (KAF), and sinus rhythm (SR). Methods- From June 2012 to January 2013, 19 604 patients with acute ischemic stroke were admitted to 219 urban hospitals in the China National Stroke Registry II. Based on heart rhythm assessed during admission, we classified patients as AFDAS, KAF, or SR. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.024176DOI Listing

Arteriopathy Influences Pediatric Ischemic Stroke Presentation, but Sickle Cell Disease Influences Stroke Management.

Stroke 2019 May;50(5):1089-1094

Departments of Pediatrics, Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas and Children's Health Dallas (M.M.D.).

Background and Purpose- Sickle cell disease (SCD) and arteriopathy are pediatric stroke risk factors that are not mutually exclusive. The relative contributions of sickled red blood cells and arteriopathy to stroke risk are unknown, resulting in unclear guidelines for primary and secondary stroke prevention when both risk factors are present. We hypothesized that despite similarities in clinical presentation and radiographic appearance of arteriopathies, stroke evaluation and management differ in children with SCD compared with those without SCD. Read More

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.022800
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http://dx.doi.org/10.1161/STROKEAHA.118.022800DOI Listing
May 2019
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Safety and Outcomes of Tenecteplase in Moderate and Severe Ischemic Stroke.

Stroke 2019 May;50(5):1279-1281

Department of Neurosurgery (N.L.), Haukeland University Hospital, Bergen, Norway.

Background and Purpose- Tenecteplase represents a promising alternative to alteplase as thrombolytic treatment in acute ischemic stroke. There are limited data on tenecteplase 0.4 mg/kg in patients with increased stroke severity. Read More

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http://dx.doi.org/10.1161/STROKEAHA.119.025041DOI Listing

Risk Factors and Outcomes for Sepsis after Appendectomy in Adults.

Surg Infect (Larchmt) 2019 Apr 20. Epub 2019 Apr 20.

Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, New York.

Sepsis is an uncommon occurrence after appendectomy, but the morbidity and mortality of patients who develop sepsis after appendectomy remains exceedingly high. The purpose of this study is to identify risk factors and adverse post-operative outcomes associated with sepsis after appendectomy in adults. The American College of Surgery National Surgical Quality Improvement Program participant user database was queried from 2012 to 2015. Read More

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https://www.liebertpub.com/doi/10.1089/sur.2019.003
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http://dx.doi.org/10.1089/sur.2019.003DOI Listing
April 2019
2 Reads

Pattern and Outcome of Uveitis in a Tertiary Military Hospital in Thailand.

Ocul Immunol Inflamm 2019 Apr 22:1-9. Epub 2019 Apr 22.

a Ocular inflammation and infection division, Department of Ophthalmology, Phramongkutklao hospital , Phramongkutklao college of Medicine , Bangkok , Thailand.

Background: Causes of uveitis vary upon the epidemiologic, racial, and geographical variations.

Objective: The objective of the study is to analyze pattern and outcome of uveitis in Phramongkutklao Hospital.

Methods: This is a retrospective study. Read More

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http://dx.doi.org/10.1080/09273948.2019.1589527DOI Listing

Patient Satisfaction and Treatments Offered to Swedish Patients with Suspected Pediatric Acute-Onset Neuropsychiatric Syndrome and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections.

J Child Adolesc Psychopharmacol 2019 Apr 19. Epub 2019 Apr 19.

1 Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.

Pediatric acute-onset neuropsychiatric syndrome (PANS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are subtypes of Obsessive-Compulsive Disorder (OCD) with suggested autoimmune etiology. Immunomodulatory treatments have been introduced as treatment options. A recent systematic review concluded that the evidence for all treatment options for PANS and PANDAS is inconclusive. Read More

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http://dx.doi.org/10.1089/cap.2018.0141DOI Listing

Differential response of human blood leukocytes to brushite, monetite, and calcium polyphosphate biomaterials.

J Biomed Mater Res B Appl Biomater 2019 Apr 22. Epub 2019 Apr 22.

Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.

Calcium phosphate-based biomaterials are extensively used for bone replacement and regeneration in orthopedic, dental, and maxillofacial surgical applications. The injury induced by surgical implantation of bone replacement graft materials initiates a cascade of host responses, starting with blood-biomaterial contact, protein adsorption on the material surface, blood coagulation, and leukocyte responses. During the initial acute inflammatory response, polymorphonuclear neutrophils (PMNs) and monocytes, abundant circulating leukocytes of the myeloid lineage, are recruited to the site of inflammation. Read More

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http://dx.doi.org/10.1002/jbm.b.34385DOI Listing

Melatonin Stabilizes Rupture-Prone Vulnerable Plaques via Regulating Macrophage Polarization in a Nuclear Circadian Receptor RORα-Dependent Manner.

J Pineal Res 2019 Apr 22:e12581. Epub 2019 Apr 22.

State Key Laboratory for Oncogenes and Related Genes, Division of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai Cancer Institute, Shanghai, China.

Rupture of vulnerable plaques is the main trigger of acute cardio-cerebral vascular events, but mechanisms responsible for transforming a stable atherosclerotic into a vulnerable plaque remain largely unknown. Melatonin, an indoleamine hormone secreted by the pineal gland, plays pleiotropic roles in the cardiovascular system; however, the effect of melatonin on vulnerable plaque rupture and its underlying mechanisms remain unknown. Here, we generated a rupture-prone vulnerable carotid plaque model induced by endogenous renovascular hypertension combined with low shear stress in hypercholesterolemic ApoE mice. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jpi.12581
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http://dx.doi.org/10.1111/jpi.12581DOI Listing
April 2019
2 Reads

Novel Role of Macrophage Migration Inhibitory Factor in Upstream Control of the Unfolded Protein Response after Ethanol Feeding in Mice.

Alcohol Clin Exp Res 2019 Apr 22. Epub 2019 Apr 22.

Center for Liver Disease Research, Department of Inflammation and Immunity - Cleveland Clinic, Cleveland, OH, United States.

Introduction: Macrophage migration inhibitory factor (MIF), a pluripotent immune regulator, is an emerging mediator in Alcohol-related Liver Disease (ALD). MIF is associated with ALD progression through its chemokine- and cytokine-like activities.

Methods: Mechanistic studies into the role of MIF in ethanol-induced liver injury were performed in Mif mice and in C57BL/6J mice treated with a small molecule MIF antagonist, MIF098, after Gao-Binge (acute-on-chronic) ethanol feeding, an ethanol feeding protocol associated with hepatic neutrophilia and induction of the Unfolded Protein Response (UPR). Read More

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http://dx.doi.org/10.1111/acer.14065DOI Listing

Fourth European stroke science workshop.

Eur Stroke J 2018 Sep 24;3(3):206-219. Epub 2018 May 24.

Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.

Lake Eibsee, Garmisch-Partenkirchen, 16 to 18 November, 2017: The European Stroke Organisation convened >120 stroke experts from 21 countries to discuss latest results and hot topics in clinical, translational and basic stroke research. Since its inception in 2011, the European Stroke Science Workshop has become a cornerstone of European Stroke Organisation's academic activities and a major highlight for researchers in the field. Participants include stroke researchers at all career stages and with different backgrounds, who convene for plenary lectures and discussions. Read More

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http://dx.doi.org/10.1177/2396987318774443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453207PMC
September 2018
2 Reads

Severity stratification and prognostic prediction of patients with acute pancreatitis at early phase: A retrospective study.

Medicine (Baltimore) 2019 Apr;98(16):e15275

Department of Emergency Medicine, Beijing Chao-yang Hospital.

Severity stratification and prognostic prediction at early stage is crucial for reducing the rates of mortality of patients with acute pancreatitis (AP). We aim to investigate the predicting performance of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red-cell distribution width (RDW) combined with severity scores (sequential organ failure assessment [SOFA], bed-side index for severity of AP [BISAP], Ranson criteria, and acute physiology and chronic health evaluation II [APACHE II]) for severe AP (SAP) and mortality.A total of 406 patients diagnosed with AP admitted in a tertiary teaching hospital were enrolled. Read More

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http://dx.doi.org/10.1097/MD.0000000000015275DOI Listing

The efficacy of renal replacement therapy strategies for septic-acute kidney injury: A PRISMA-compliant network meta-analysis.

Medicine (Baltimore) 2019 Apr;98(16):e15257

Department of Critical Care Medicine, Anqing Municipal Hospital, Anqing, Anhui, China.

Background: Renal replacement therapy (RRT) is the main treatment for patients with sepsis-induced acute kidney injury (SAKI). However, the choice of RRT strategy remains controversial.

Objective: This study assessed the effectiveness of RRT variants in SAKI patients by a network meta-analysis. Read More

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http://dx.doi.org/10.1097/MD.0000000000015257DOI Listing

The clinical efficacy and safety of the Chinese herbal medicine Astragalus (Huangqi) preparation for the treatment of acute myocardial infarction: A systematic review of randomized controlled trials.

Medicine (Baltimore) 2019 Apr;98(16):e15256

School of Chinese Medicine.

Background: In recent years, with the enormous advances in the field of cardiac intervention technology, the survival rate of patients with acute myocardial infarction (AMI) has been improved significantly. However, the risk of arrhythmias and heart failure remains very high in AMI patients for long-term prognosis. Chinese herbal medicine (CHM) is more and more used in the treatment of AMI because of its good curative effect and less side effects. Read More

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http://dx.doi.org/10.1097/MD.0000000000015256DOI Listing

Pediatric ovarian tumors, a challenge for pediatrician and gynecologist: Three case reports (CARE compliant).

Medicine (Baltimore) 2019 Apr;98(16):e15242

University of Medicine, Pharmacy, Sciences and Technology Târgu Mureş, Romania.

Rationale: Ovarian or adnexal tumors are very rare in patients below the age of 18 years, most of them being functional cysts, only 10% being malignant. We report 3 cases of ovarian tumors with the aim of revealing the particularities regarding the diagnosis and management of benign and malignant ovarian tumors in pediatric patients.

Patient Concerns: The 1st case, a 9-year-old girl presented for diffuse abdominal pain, distended abdomen and rapid increase in abdominal volume. Read More

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http://dx.doi.org/10.1097/MD.0000000000015242DOI Listing

Tension pneumothorax-induced Takotsubo syndrome: A case report.

Medicine (Baltimore) 2019 Apr;98(16):e15190

Rationale: Takotsubo syndrome (TTS) is a form of acute and usually reversible heart failure syndrome. Transient left ventricular dysfunction and electrocardiographic changes could mimic acute coronary syndrome but there are actually no obstructive coronary lesions.

Patient Concerns: A 76-year-old woman with chronic lung disease developed spontaneous tension pneumothorax with the presentation of severe dyspnea, respiratory failure, left ventricular dysfunction, and anterior wall ST-segment elevation on 12-lead electrocardiogram. Read More

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http://dx.doi.org/10.1097/MD.0000000000015190DOI Listing

Chemotherapy-induced peripheral neuropathy: where are we now?

Authors:
Lesley A Colvin

Pain 2019 May;160 Suppl 1:S1-S10

Chair of Pain Medicine, Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland.

Chemotherapy-induced peripheral neuropathy (CIPN) is a major challenge, with increasing impact as oncological treatments, using potentially neurotoxic chemotherapy, improve cancer cure and survival. Acute CIPN occurs during chemotherapy, sometimes requiring dose reduction or cessation, impacting on survival. Around 30% of patients will still have CIPN a year, or more, after finishing chemotherapy. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001540DOI Listing

Early Immunologic Response in Multiply Injured Patients With Orthopaedic Injuries Is Associated With Organ Dysfunction.

J Orthop Trauma 2019 May;33(5):220-228

Indiana University Health Methodist Hospital, Indianapolis, IN.

Objectives: To quantify the acute immunologic biomarker response in multiply injured patients with axial and lower extremity fractures and to explore associations with adverse short-term outcomes including organ dysfunction and nosocomial infection (NI).

Design: Prospective cohort study.

Setting: Level 1 academic trauma center. Read More

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http://dx.doi.org/10.1097/BOT.0000000000001437DOI Listing
May 2019
1 Read

Complications of Postoperative Epidural Analgesia for Oncologic Surgery: A Review of 18,895 Cases.

Clin J Pain 2019 Apr 18. Epub 2019 Apr 18.

The Department of Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.

Objectives: The risks of epidural analgesia differ depending on the population studied. We describe our experience with postoperative epidural analgesia for oncologic surgery.

Materials And Methods: After approval from the Institutional Review Board of The University of Texas MD Anderson Cancer Center to conduct this retrospective analysis, we searched our acute pain medicine database for cases in which postoperative epidural analgesia was used between 2003 and 2012. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000718DOI Listing

Acute Flares of Knee Osteoarthritis (the ACT-FLARE Study): Protocol for a Web-Based Case-Crossover Study in Community-Dwelling Adults.

JMIR Res Protoc 2019 Apr 22;8(4):e13428. Epub 2019 Apr 22.

Primary Care Centre Versus Arthritis, Research Institute for Primary Care and Health Sciences, Keele University, Staffordshire, United Kingdom.

Background: The cardinal feature of osteoarthritis (OA) is pain. Although heterogeneity in pain and function have been demonstrated in the long-term course of OA, the more proximate determinants of acute flare-ups remain less clear. How short-term intermittent or transient exposures trigger acute flare-ups has important implications for effective and sustainable self-management strategies. Read More

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https://www.researchprotocols.org/2019/4/e13428/
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http://dx.doi.org/10.2196/13428DOI Listing
April 2019
1 Read

Drug discovery strategies for acute radiation syndrome.

Expert Opin Drug Discov 2019 Apr 22:1-15. Epub 2019 Apr 22.

b Scientific Research Department , Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences , Bethesda , MD , USA.

Introduction: There are at the minimum two major, quite different approaches to advance drug discovery. The first being the target-based drug discovery (TBDD) approach that is commonly referred to as the molecular approach. The second approach is the phenotype-based drug discovery (PBDD), also known as physiology-based drug discovery or empirical approach. Read More

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http://dx.doi.org/10.1080/17460441.2019.1604674DOI Listing

Intramuscular sodium tetrathionate as an antidote in a clinically relevant swine model of acute cyanide toxicity.

Clin Toxicol (Phila) 2019 Apr 22:1-7. Epub 2019 Apr 22.

a Department of Emergency Medicine, School of Medicine , University of Colorado , Aurora , CO , USA.

Background: Cyanide is a metabolic poison used in multiple industries and is a high threat chemical agent. Current antidotes require intravenous administration, limiting their usefulness in a mass casualty scenario. Sodium tetrathionate reacts directly with cyanide yielding thiosulfate and the non-toxic compound thiocyanate. Read More

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https://www.tandfonline.com/doi/full/10.1080/15563650.2019.1
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http://dx.doi.org/10.1080/15563650.2019.1602272DOI Listing
April 2019
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Incremental value of high-frequency QRS analysis for diagnosis and prognosis in suspected exercise-induced myocardial ischaemia.

Eur Heart J Acute Cardiovasc Care 2019 Apr 22:2048872619842988. Epub 2019 Apr 22.

1 Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Switzerland.

Aim: Exercise stress testing is used to detect myocardial ischaemia, but is limited by low sensitivity and specificity. The authors investigated the value of the analysis of high-frequency QRS components as a marker of abnormal depolarization in addition to standard ST-deviations as a marker of abnormal repolarization to improve the diagnostic accuracy.

Methods And Results: Consecutive patients undergoing bicycle exercise stress nuclear myocardial perfusion imaging were prospectively enrolled. Read More

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http://dx.doi.org/10.1177/2048872619842988DOI Listing

Estimating outcome probabilities from early symptom changes in cognitive therapy for recurrent depression.

J Consult Clin Psychol 2019 Apr 22. Epub 2019 Apr 22.

Department of Psychiatry, The University of Texas Southwestern Medical Center.

Objective: Acute-phase cognitive therapy (CT) is an efficacious treatment for major depressive disorder (MDD) producing benefits comparable to pharmacotherapy, but not all patients respond or remit. The purpose of the current analyses was to estimate CT patients' probability of nonresponse and remission from symptom improvement early in treatment.

Method: Data from 2 clinical trials of acute-phase CT for recurrent depression were pooled for analysis (N = 679). Read More

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http://dx.doi.org/10.1037/ccp0000409DOI Listing

Ultrasonographic features of presumed gastric wall edema in 14 dogs with pancreatitis.

J Vet Intern Med 2019 Apr 22. Epub 2019 Apr 22.

Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana.

Background: Gastric wall edema has not been reported as a complication of acute pancreatitis in dogs.

Objective: To describe the ultrasonographic features of gastric wall thickening in dogs with acute pancreatitis.

Animals: Fourteen dogs with ultrasonographic evidence and clinical diagnosis of acute pancreatitis, with ultrasonographic evidence of increased gastric wall thickness (>5 mm). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jvim.15507
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http://dx.doi.org/10.1111/jvim.15507DOI Listing
April 2019
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A proposed technique to visualize and classify uterosacral ligament deep endometriosis with and without infiltration into the parametrium or torus uterinus.

Ultrasound Obstet Gynecol 2019 Apr 22. Epub 2019 Apr 22.

Acute Gynecology, Early Pregnancy & Advanced Endoscopic Surgery Unit, Nepean Hospital, Sydney, Australia.

Deep endometriosis (DE) of the uterosacral ligaments (USLs) has been reported to be the most common site of DE in the pelvis . A nodule within the USL may infiltrate the parametrium, increasing the complexity of surgical resection and larger nodules noted on transvaginal ultrasound (TVS) (≥17mm) should raise suspicion for ureteral involvement . Nodules may also invade the torus uterinus, the thickening between the insertion of the USLs behind the posterior cervix. Read More

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http://dx.doi.org/10.1002/uog.20300DOI Listing

One year outcome of high-risk newborn infants discharged from the neonatal care unit of the National Maternal and Child Health Center in Cambodia.

Heliyon 2019 Apr 9;5(4):e01446. Epub 2019 Apr 9.

Bureau of International Health Cooperation, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku, Tokyo 162-8655, Japan.

Background: In the National Maternal and Child Health Center in Cambodia, about 7,500 newborn infants are born every year. Around 10% of them are admitted to the neonatal care unit. After recovery from the acute phase that presented neonatal care unit admissions, they are discharged even if they are very low birth weight infants, but there is no official follow-up system available after discharge. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24058440183210
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http://dx.doi.org/10.1016/j.heliyon.2019.e01446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458445PMC
April 2019
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First year post-stroke healthcare costs and fall-status among those discharged to the community.

Eur Stroke J 2018 Sep 15;3(3):254-262. Epub 2018 Mar 15.

School of Physiotherapy, Royal College of Surgeons in Ireland, Dublin, Ireland.

Introduction: Falls are common post-stroke events but their relationship with healthcare costs is unclear. The aim of this study was to examine the relationship between healthcare costs in the first year after stroke and falls among survivors discharged to the community.

Patients And Methods: Survivors of acute stroke with planned home discharges from five large hospitals in Ireland were recruited. Read More

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http://dx.doi.org/10.1177/2396987318764954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453204PMC
September 2018
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Falls-Related EvEnts in the first year after StrokE in Ireland: Results of the multi-centre prospective FREESE cohort study.

Eur Stroke J 2018 Sep 16;3(3):246-253. Epub 2018 Mar 16.

School of Physiotherapy, Royal College of Surgeons in Ireland, Dublin, Ireland.

Introduction: Falls are common post-stroke adverse events. This study aimed to describe the first-year falls incidence, circumstances and consequences among persons discharged home after stroke in Ireland, and to examine the association between potential risk factors and recurrent falls.

Patients And Methods: Patients with acute stroke and planned home-discharge were recruited consecutively from five hospitals. Read More

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http://dx.doi.org/10.1177/2396987318764961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453197PMC
September 2018

European Stroke Organisation certification of stroke units and stroke centres.

Eur Stroke J 2018 Sep 24;3(3):220-226. Epub 2018 May 24.

Department of Neurology and Stroke Center, University Hospital Basel, Basel, Switzerland.

To improve quality and to overcome the wide discrepancies in stroke care both within- and between European countries, the European Stroke Organisation Executive Committee initiated in 2007 activities to establish certification processes for stroke units and stroke centres. The rapidly expanding evidence base in stroke care provided the mandate for the European Stroke Organisation Stroke Unit-Committee to develop certification procedures for stroke units and stroke centres with the goals of setting standards for stroke treatment in Europe, improving quality and minimising variation. The purpose of this article is to present the certification criteria and the auditing process for stroke units and stroke centres that aim to standardise and harmonise care for stroke patients, and hence become members of the European Stroke Organisation Stroke Unit and Stroke Centre network. Read More

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http://dx.doi.org/10.1177/2396987318778971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453203PMC
September 2018

Statistical analysis plan for the 'Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)'.

Eur Stroke J 2018 Jun 1;3(2):193-196. Epub 2018 Feb 1.

1Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK.

Rationale: Glyceryl trinitrate, a nitric oxide donor, is a candidate treatment for acute stroke; it lowers blood pressure, does not alter cerebral blood flow or platelet function and is neuroprotective in experimental stroke. The ongoing rapid intervention with glyceryl trinitrate in hypertensive stroke trial-2 trial aims to assess the safety and efficacy of paramedic-delivered glyceryl trinitrate in patients with ultra-acute stroke. The rapid intervention with glyceryl trinitrate in hypertensive stroke trial-2 trial is a multicentre UK-based prospective randomised sham-controlled outcome-blinded parallel-group trial in patients with presumed stroke who present to the ambulance service following a 999 emergency call. Read More

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http://dx.doi.org/10.1177/2396987318756696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460414PMC

In-hospital dynamics of glucose, blood pressure and temperature predict outcome in patients with acute ischaemic stroke.

Eur Stroke J 2018 Jun 16;3(2):174-184. Epub 2018 Mar 16.

Department of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School, Alexandra Hospital, Athens, Greece.

Introduction: We aimed to assess alterations in glucose, blood pressure and temperature in acute ischaemic stroke and investigate their association with early all-cause mortality and functional outcome.

Patients And Methods: We studied all consecutive acute ischaemic stroke patients admitted in 2001-2010 to the Acute Stroke Unit, at Alexandra University Hospital, in Athens. Serial measurements were performed in the first seven days post-stroke and different parameters have been estimated: mean daily values, variability, subject-specific baseline levels and rate of change in serial measurements. Read More

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http://dx.doi.org/10.1177/2396987318765824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460405PMC

Drip and ship versus direct to endovascular thrombectomy: The impact of treatment times on transport decision-making.

Eur Stroke J 2018 Jun 14;3(2):126-135. Epub 2018 Feb 14.

Beaumont Hospital, Dublin, Ireland.

Introduction: In ischaemic stroke care, fast reperfusion is essential for disability free survival. It is unknown if bypassing thrombolysis centres in favour of endovascular thrombectomy (mothership) outweighs transport to the nearest thrombolysis centre for alteplase and then transfer for endovascular thrombectomy (drip-and-ship). We use conditional probability modelling to determine the impact of treatment times on transport decision-making for acute ischaemic stroke. Read More

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http://dx.doi.org/10.1177/2396987318759362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460407PMC

Does stroke health promotion increase awareness of appropriate behavioural response? Impact of the face, arm, speech and time (FAST) campaign on population knowledge of stroke risk factors, warning signs and emergency response.

Eur Stroke J 2018 Jun 11;3(2):117-125. Epub 2018 Jan 11.

3Department of Epidemiology & Public Health Medicine, Division of Population Health Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

Introduction: Inability to identify stroke warning signs accurately is an important cause of delay in seeking medical attention, leading to potential ineligibility for acute intervention. We report on post-campaign findings (wave 2) of national surveys to estimate changes in population knowledge following a media-based Face, Arm, Speech, Time stroke awareness campaign, comparing findings to those of a pre-campaign population survey (wave 1). One thousand and ten randomly selected adults (18+) completed the Stroke Awareness Questionnaire on knowledge of warning signs, risk factors and response to stroke at wave 2 and findings were compared to wave 1 survey results. Read More

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http://dx.doi.org/10.1177/2396987317753453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460411PMC
June 2018
1 Read