6,370 results match your criteria Acute Tubular Necrosis


Cisplatin-induced renal toxicity in elderly people.

Ther Adv Med Oncol 2020 18;12:1758835920923430. Epub 2020 May 18.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.

Despite available prevention and treatment measures, such as hydration, diuresis, magnesium supplementation, and amifostine, renal toxicity is still one of the major dose-limiting side effects of cisplatin. The aim of this review is to discuss the issue of cisplatin-induced nephrotoxicity in the elderly. Compared with young patients, the incidences of cisplatin-induced nephrotoxicity and acute kidney injury (AKI) in elderly patients are significantly increased, and survival time may be decreased. Read More

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http://dx.doi.org/10.1177/1758835920923430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238313PMC

Asymmetric copolymer vesicles to serve as a hemoglobin vector for ischemia therapy.

Biomater Sci 2014 Sep 17;2(9):1254-1261. Epub 2014 Jun 17.

State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.

Self-aggregated vesicles have been considered to be promising candidates for hemoglobin-based oxygen carriers. Here, amphiphilic hetero-triblock copolymers are designed and synthesized with the capacity to self-assemble into polymer vesicles (polymersomes). Conceivably, vesicles are formed with asymmetric membranes, which achieve enhanced encapsulation efficiency of hemoglobin (Hb) beyond the diblock counterpart. Read More

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http://dx.doi.org/10.1039/c4bm00123kDOI Listing
September 2014

Current status of imaging diagnosis in the transplanted kidney. A review of the literature with a special focus on contrast-enhanced ultrasonography.

Med Pharm Rep 2020 Apr 22;93(2):133-144. Epub 2020 Apr 22.

Medical Imaging Department, "Octavian Fodor" Institute of Gastroenterology and Hepatology and Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Objectives: Ultrasonographic scanning is currently the most widespread imaging diagnostic procedure. The method provides real-time morphological, vascular and elastographic information in a non-invasive manner. In recent years, harmonic vascular examination has become accessible using intravenous contrast agents. Read More

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http://dx.doi.org/10.15386/mpr-1536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243885PMC

Pathophysiology of Contrast-Induced Acute Kidney Injury.

Interv Cardiol Clin 2020 Jul 12;9(3):293-298. Epub 2020 May 12.

Division of Nephrology, UT Health at San Antonio, 7703 Floyd Curl Dr, MSC 7882, San Antonio, TX 78229, USA.

Passing contrast media through the renal vascular bed leads to vasoconstriction. The perfusion decrease leads to ischemia of tubular cells. Through ischemia and direct toxicity to renal tubular cells, reactive oxygen species formation is increased, enhancing the effect of vasoconstrictive mediators and decreasing the bioavailability of vasodilative mediators. Read More

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http://dx.doi.org/10.1016/j.iccl.2020.03.001DOI Listing

Cyclophilin A Promotes Inflammation in Acute Kidney Injury but Not in Renal Fibrosis.

Int J Mol Sci 2020 May 22;21(10). Epub 2020 May 22.

Department of Nephrology, Monash Health, Monash Medical Centre, Clayton, Victoria 3168, Australia.

Cyclophilin A (CypA) is a highly abundant protein in the cytoplasm of most mammalian cells. Beyond its homeostatic role in protein folding, CypA is a Damage-Associated Molecular Pattern which can promote inflammation during tissue injury. However, the role of CypA in kidney disease is largely unknown. Read More

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http://dx.doi.org/10.3390/ijms21103667DOI Listing

Predictors of Renal Complications in Children With Hematotoxic Snakebite.

Indian Pediatr 2020 May;57(5):427-430

Department of Pediatrics, Burdwan Medical College, Burdwan, India.

Objective: To study the predictors of renal complications following hematotoxic snakebite in children.

Methods: This comparative study was conducted in the pediatric ward of a tertiary-care centre among 364 consecutively children admitted with hematotoxic snakebite between January 2016 and December 2017. Clinical and laboratory indicators were compared between children who developed acute kidney injury and those who did not. Read More

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Paraquat Poisoning: A Retrospective Study of 55 Patients From a Tertiary Care Center in Southern India.

Indian J Crit Care Med 2020 Mar;24(3):155-159

Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Background: In India the data on paraquat (PQ) poisoning are limited to case reports and small case series. Hence, this study was carried out to understand the clinical features and outcomes of PQ poisoning. We also briefly report the relevant Indian studies on PQ poisoning. Read More

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http://dx.doi.org/10.5005/jp-journals-10071-23369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225766PMC

Management of acute kidney injury in COVID-19.

Cleve Clin J Med 2020 May 20. Epub 2020 May 20.

Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic.

Acute kidney injury has been reported in as many as 29% of COVID-19 patients. Reported risk factors include elevated baseline serum creatinine, elevated blood urea nitrogen, acute kidney injury, proteinuria, and hematuria. Suspected causes include sepsis and acute tubular necrosis resulting from renal hypoperfusion, cytokine release syndrome, direct viral invasion, renal medullary hypoxia secondary to alveolar damage, rhabdomyolysis, and cardiorenal syndrome due to viral myocarditis. Read More

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http://dx.doi.org/10.3949/ccjm.87a.ccc034DOI Listing

Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome: Results From a Prospective, Single-Center, Clinicopathologic Case Series.

Ann Intern Med 2020 May 14. Epub 2020 May 14.

Medical University of Vienna, Vienna, Austria (M.T.).

Background: Coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become pandemic, with substantial mortality.

Objective: To evaluate the pathologic changes of organ systems and the clinicopathologic basis for severe and fatal outcomes.

Design: Prospective autopsy study. Read More

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http://dx.doi.org/10.7326/M20-2566DOI Listing

Acute kidney injury in pregnant women following SARS-CoV-2 infection: A case report from Iran.

Respir Med Case Rep 2020 May 13:101090. Epub 2020 May 13.

Tuberculosis and Lung Disease Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.

We reported a 33-year-old female case with novel coronavirus disease 2019 (COVID-19) accompanied by Acute tubular necrosis (ATN). She had a gestational age of 34 weeks. The patient referred to treatment clinic for COVID-19 in Imam Reza hospital of Tabriz (Iran) after having flu-like symptoms. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219375PMC

Timing of Initiation of Renal Replacement Therapy in Sepsis-Associated Acute Kidney Injury.

J Clin Med 2020 May 10;9(5). Epub 2020 May 10.

Division of Nephrology and Renal Transplantation, Department of Medicine Centro Hospitalar Lisboa Norte, EPE Av. Prof. Egas Moniz, 1649-035 Lisboa, Portugal.

Sepsis-associated acute kidney injury (SA-AKI) is a major issue in medical, surgical and intensive care settings and is an independent risk factor for increased mortality, as well as hospital length of stay and cost. SA-AKI encompasses a proper pathophysiology where renal and systemic inflammation play an essential role, surpassing the classic concept of acute tubular necrosis. No specific treatment has been defined yet, and renal replacement therapy (RRT) remains the cornerstone supportive therapy for the most severe cases. Read More

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http://dx.doi.org/10.3390/jcm9051413DOI Listing

Baicalin attenuates lipopolysaccharide-induced renal tubular epithelial cell injury by inhibiting the TXNIP/NLRP3 signalling pathway via increasing miR-223-3p expression.

J Biol Regul Homeost Agents 2020 Jan-Feb;34(1):69-82

Department of Nephrology, The Sixth Affiliated Hospital of Kunming Medical University, Hongta District, Yuxi, China.

Baicalin has been used in China to treat inflammation-related diseases, such as inflammation-induced acute kidney injury (AKI). However, the specific mechanism of baicalin remains unclear. To observe the protective effects of baicalin on lipopolysaccharide (LPS)-induced inflammatory injury of renal tubular epithelial cells (HK-2 cells) and to explore its protective mechanism. Read More

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http://dx.doi.org/10.23812/19-502-ADOI Listing

Predictive Nephrotoxicity Profiling of a Novel Antifungal Small Molecule in Comparison to Amphotericin B and Voriconazole.

Front Pharmacol 2020 24;11:511. Epub 2020 Apr 24.

National Dental Centre Singapore, Oral Health ACP, Duke-NUS Medical School, Singapore, Singapore.

Background And Purpose: is the major fungal species associated with superficial mucosal infections such as oral candidiasis as well as systemic mycoses with high morbidity and mortality. On top of the rising drug resistance, currently available antifungal agents have significant adverse effects. Nephrotoxicity is the major treatment complication associated with antifungal agents. Read More

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http://dx.doi.org/10.3389/fphar.2020.00511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193989PMC

Selective nanoparticle-mediated targeting of renal tubular Toll-like receptor 9 attenuates ischemic acute kidney injury.

Kidney Int 2020 Feb 22. Epub 2020 Feb 22.

Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York, USA. Electronic address:

We developed an innovative therapy for ischemic acute kidney injury with discerning kidney-targeted delivery of a selective Toll-like receptor 9 (TLR9) antagonist in mice subjected to renal ischemia reperfusion injury. Our previous studies showed that mice deficient in renal proximal tubular TLR9 were protected against renal ischemia reperfusion injury demonstrating a critical role for renal proximal tubular TLR9 in generating ischemic acute kidney injury. Herein, we used 300-400 nm polymer-based mesoscale nanoparticles that localize to the renal tubules after intravenous injection. Read More

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http://dx.doi.org/10.1016/j.kint.2020.01.036DOI Listing
February 2020

Toll-like receptor-2 mediates systemic inflammation in gentamicin-induced rat nephrotoxicity.

Clin Exp Pharmacol Physiol 2020 May 8. Epub 2020 May 8.

Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Gentamicin is an aminoglycoside antibiotic commonly administrated to patients with gram-negative infections. Gentamicin induced nephrotoxicity by functional and structural impairment. Toll like receptors (TLRs) as key mediators in the innate and adaptive immune system response involved in gentamicin induced-nephrotoxicity. Read More

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http://dx.doi.org/10.1111/1440-1681.13334DOI Listing

A Unique Case of Metformin-associated Severe Lactic Acidosis Without Preexisting Renal Disease: Perspectives on Prolonged Dialysis and Education for Prevention.

Cureus 2020 Apr 6;12(4):e7564. Epub 2020 Apr 6.

Nephrology, Raymond G. Murphy Veterans Affairs Medical Center, Albuquerque, USA.

Metabolic acidosis is a common disorder defined by an imbalance in the body's acid-base balance. Identifying the cause of acidosis is critical for its management. We describe a case of acute renal failure with lactic acidosis in a 69-year-old man who was taking metformin for type 2 diabetes. Read More

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http://dx.doi.org/10.7759/cureus.7564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202579PMC

Dexmedetomidine Preconditioning Protects Rats from Renal Ischemia-Reperfusion Injury Accompanied with Biphasic Changes of Nuclear Factor-Kappa B Signaling.

J Immunol Res 2020 17;2020:3230490. Epub 2020 Apr 17.

Department of Anesthesiology, Hospital of China Medical University, 155 Nanjingbei Street, Heping District, Shenyang, Liaoning 110001, China.

Acute kidney injury (AKI) is one of the most common and troublesome perioperative complications. Dexmedetomidine (DEX) is a potent 2-adrenoceptor (2-AR) agonist with anti-inflammatory and renoprotective effects. In this study, a rat renal ischemia-reperfusion injury (IRI) model was induced. Read More

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http://dx.doi.org/10.1155/2020/3230490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183529PMC

Effects of bodybuilding supplements on the kidney: A population-based incidence study of biopsy pathology and clinical characteristics among middle eastern men.

BMC Nephrol 2020 May 6;21(1):164. Epub 2020 May 6.

Department of Pathology, University of Sulaimani College of Medicine and Shoresh Teaching Hospital, Quirga Road, Sulaimani, Iraq.

Background: The incidence of kidney diseases among bodybuilders is unknown.

Methods: Between January 2011 and December 2019, the Iraqi Kurdistan 15 to 39 year old male population averaged 1,100,000 with approximately 56,000 total participants and 25,000 regular participants (those training more than 1 year). Annual age specific incidence rates (ASIR) with (95% confidence intervals) per 100,000 bodybuilders were compared with the general age-matched male population. Read More

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http://dx.doi.org/10.1186/s12882-020-01834-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203829PMC

Acute Renal Failure/Acute Kidney Injury (AKI) Associated with Endovascular Procedures.

Diagnostics (Basel) 2020 May 2;10(5). Epub 2020 May 2.

Department of Nephrology, Transplantology and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, Poland.

AKI is one of the most common underdiagnosed postoperative complications that can occur after any type of surgery. Contrast-induced nephropathy (CIN) is still poorly defined and due a wide range of confounding individual variables, its risk is difficult to determine. CIN mainly affects patients with underlying chronic kidney disease, diabetes, sepsis, heart failure, acute coronary syndrome and cardiogenic shock. Read More

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http://dx.doi.org/10.3390/diagnostics10050274DOI Listing

Dehydration-associated chronic kidney disease: a novel case of kidney failure in China.

BMC Nephrol 2020 May 4;21(1):159. Epub 2020 May 4.

Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.

Background: Mesoamerican nephropathy (MeN) is a pattern of chronic kidney disease (CKD) prevalent among Central American men who work in agriculture, and its underlying cause has not been elucidated. Currently, experts hypothesize that MeN is related to repeated episodes of occupational heat stress leading to water loss and hence it is also called dehydration-associated CKD.

Case Presentation: We report a case of a 40-year-old man, whose first admission to Peking Union Medical College Hospital was due to acute kidney injury (AKI). Read More

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http://dx.doi.org/10.1186/s12882-020-01804-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199376PMC

Renal Toxicity From Pemetrexed and Pembrolizumab in the Era of Combination Therapy in Patients With Metastatic Nonsquamous Cell NSCLC.

J Thorac Oncol 2020 Apr 30. Epub 2020 Apr 30.

Department of Pulmonary Medicine, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

The combination of chemotherapy and immune checkpoint inhibition (ICI) therapy is the current standard of care for most patients who are fit to undergo treatment for metastatic NSCLC. With this combination, renal toxicity was slightly higher than with chemotherapy alone in initial clinical trials. However, in recent real-world data, loss of kidney function is reported to be more frequent. Read More

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http://dx.doi.org/10.1016/j.jtho.2020.04.021DOI Listing

Novel biomarkers of acute kidney injury in children: an update on recent findings.

Curr Opin Pediatr 2020 Jun;32(3):354-359

Department of Pediatrics, Section of Nephrology, Yale University School of Medicine.

Purpose Of Review: The clinical diagnosis of acute kidney injury (AKI) relies largely on changes in serum creatinine; a delayed biomarker. Research in children has been focused on developing novel AKI biomarkers, which can improve the prediction, early detection and diagnosis of kidney injury, as well as our understanding of AKI pathophysiology. In this review, we describe recently published studies on urine or blood biomarkers of AKI. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000891DOI Listing

Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China.

Kidney Int 2020 Apr 9. Epub 2020 Apr 9.

Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Although the respiratory and immune systems are the major targets of Coronavirus Disease 2019 (COVID-19), acute kidney injury and proteinuria have also been observed. Currently, detailed pathologic examination of kidney damage in critically ill patients with COVID-19 has been lacking. To help define this we analyzed kidney abnormalities in 26 autopsies of patients with COVID-19 by light microscopy, ultrastructural observation and immunostaining. Read More

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http://dx.doi.org/10.1016/j.kint.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194105PMC

The Presence of Renal IgG Deposits in Necrotizing Crescentic Glomerulonephritis Associated with ANCA Is Not Related to Worse Renal Clinical Outcomes.

Kidney Dis (Basel) 2020 Mar 21;6(2):98-108. Epub 2019 Nov 21.

Department of Nephrology - Hypertension, Dialysis, Transplantation, CHRU, Tours, France.

Introduction: Classical pauci-immune necrotizing crescentic glomerulonephritis (CGN) associated with antineutrophil cytoplasmic autoantibodies (ANCA) is characterized by the absence of renal immunoglobulin (Ig) deposits. However, IgG deposits can sometimes be present. We wanted to assess whether necrotizing CGN with IgG deposits is associated with a more severe presentation and outcome than necrotizing CGN without IgG deposits. Read More

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http://dx.doi.org/10.1159/000503969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154286PMC

Ferroptosis and Necroptosis in the Kidney.

Cell Chem Biol 2020 Apr;27(4):448-462

Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Fletscherstrasse 74, 01307, Dresden, Germany. Electronic address:

In the last decade, the role of apoptosis in the pathophysiology of acute kidney injury (AKI) and AKI to chronic kidney disease (CKD) progression has been revisited as our understanding of ferroptosis and necroptosis has emerged. A growing body of evidence, reviewed here, ascribes a central pathophysiological role for ferroptosis and necroptosis to AKI, nephron loss, and acute tubular necrosis. We will introduce concepts to the non-cell-autonomous manner of kidney tubular injury during ferroptosis, a phenomenon that we refer to as a "wave of death. Read More

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http://dx.doi.org/10.1016/j.chembiol.2020.03.016DOI Listing

Novel lncRNA XLOC_032768 alleviates cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells through TNF-α.

Int Immunopharmacol 2020 Jun 8;83:106472. Epub 2020 Apr 8.

Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address:

The cellular and molecular mechanisms through which cisplatin induces nephrotoxicity have been investigated extensively. However, the role of long non-coding RNAs (lncRNAs) in cisplatin-induced nephrotoxicity is not well known. We explored the functions and underlying mechanisms of a novel lncRNA XLOC_032768 in cisplatin-induced nephrotoxicity. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106472DOI Listing

[Protective effect and mechanism of Ribociclib on sepsis induced-acute kidney injury].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2020 Feb;32(2):204-209

Department of Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, China. Corresponding author: Li Guofu, Email:

Objective: To investigate the role of Ribociclib in sepsis induced-acute kidney injury (AKI) and its possible mechanisms.

Methods: (1) Twenty adult male C57BL/6 mice were divided into sham operation group (Sham group; only open the abdomen without ligating or perforating the cecum, administered with sodium lactate buffer 12 hours before the sham operation), Ribociclib control group (administered with 150 mg/kg Ribociclib), cecal ligation and puncture (CLP) group (sepsis model induced by CLP; lactate buffer was given by intragastric administration 12 hours before CLP), and Ribociclib pretreatment group (administered with 150 mg/kg Ribociclib 12 hours before CLP) according to random number table, with 5 mice in each group. Kidneys were harvested 12 hours after the operation. Read More

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http://dx.doi.org/10.3760/cma.j.cn121430-20200108-00038DOI Listing
February 2020

[Expression characteristics of inflammatory and apoptosis factors and regulatory effect of anemoside B4 in mice with acute kidney injury].

Zhongguo Zhong Yao Za Zhi 2020 Jan;45(1):157-162

State Key Laboratory of Innovative Drugs and Efficient Energy-saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine Nanchang 330006, China.

This paper was aimed to observe the effect of anemoside B4(hereinafter referred to as B4) on cisplatin-induced acute kidney injury in mice, and to investigate its possible mechanism in renal protection from inflammation and apoptosis aspects. Mice were divided into normal group, model group, dexamethasone positive group and B4 high, middle and low dose groups(5, 2.5, and 1. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20190918.402DOI Listing
January 2020

Fatal acetaminophen poisoning with hepatic microvesicular steatosis in a child after repeated administration of therapeutic doses.

Forensic Sci Int 2020 May 17;310:110258. Epub 2020 Mar 17.

Univ Rennes, Inra, Inserm, Institut NUMECAN - UMR_A 1341, UMR_S 1241, Rennes, France; Department of Forensic Toxicology, Rennes University Hospital, Rennes, France. Electronic address:

Acetaminophen is the leading cause of acute liver failure worldwide following massive ingestion. We present here a fatal acute liver failure after repeated administration of four therapeutic doses of acetaminophen at 4-h intervals in a previously healthy 9-year-old female who presented dental pain after a facial trauma during sport practice. A diagnosis of paracetamol-induced hepatitis was deduced from the clinical picture of fulminant hepatitis and tubular necrosis, the encephalopathy with oedema and without signs of trauma. Read More

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http://dx.doi.org/10.1016/j.forsciint.2020.110258DOI Listing

Chemokine receptor 5 blockade modulates macrophage trafficking in renal ischaemic-reperfusion injury.

J Cell Mol Med 2020 May 30;24(10):5515-5527. Epub 2020 Mar 30.

Kidney Research Institute, Seoul National University, Seoul, Korea.

Chemokine receptor 5 (CCR5) is a pivotal regulator of macrophage trafficking in the kidneys in response to an inflammatory cascade. We investigated the role of CCR5 in experimental ischaemic-reperfusion injury (IRI) pathogenesis. To establish IRI, we clamped the bilateral renal artery pedicle for 30 min and then reperfused the kidney. Read More

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http://dx.doi.org/10.1111/jcmm.15207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214177PMC

Red Cell Distribution Width as a Severity Marker on the Outcome of Patients with Acute Kidney Injury on Renal Replacement Therapy.

Indian J Crit Care Med 2020 Feb;24(2):95-98

Department of Nephrology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.

Background: Acute kidney injury (AKI) requiring dialysis is associated with high mortality and morbidity. Red blood cell distribution width (RDW) has been shown as a predictor of mortality in different subsets of patients admitted to intensive care unit (ICU). This study compares the predictive ability of RDW and other severity illness prognostic models on 30 days mortality in adult patients admitted to ICUs with AKI necessitating dialysis. Read More

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http://dx.doi.org/10.5005/jp-journals-10071-23342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075065PMC
February 2020

The effect of MEK1/2 inhibitors on cisplatin-induced acute kidney injury (AKI) and cancer growth in mice.

Cell Signal 2020 Jul 16;71:109605. Epub 2020 Mar 16.

Division of Renal Diseases and Hypertension, Univ. of Colorado at Denver, Aurora, CO, USA. Electronic address:

In a clinically-relevant model of 4 week, low-dose cisplatin-induced AKI, mice were injected subcutaneously with non small cell lung cancer (NSCLC) cells that harbor an activating Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation. Phospho extracellular signal-regulated kinase1/2 (pERK1/2) expression in kidney and tumors was decreased by the MEK1/2 inhibitors, U0126 and trametinib, that potently inhibit pERK1/2. U0126 resulted in a significant improvement in kidney function, acute tubular necrosis (ATN) and tubular cell apoptosis in mice with AKI. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109605DOI Listing

Chaiqin chengqi decoction alleviates severe acute pancreatitis associated acute kidney injury by inhibiting endoplasmic reticulum stress and subsequent apoptosis.

Biomed Pharmacother 2020 May 27;125:110024. Epub 2020 Feb 27.

Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, 37# Guoxue Street, Chengdu 610041, China. Electronic address:

Background: Acute kidney injury (AKI), characterized by an increase of serum creatinine and urea, is a severe complication of severe acute pancreatitis (SAP) with high mortality. Endoplasmic reticulum (ER) stress has been considered as a key pathologic process in AKI. Chaiqin chengqi decoction (CQCQD) is an effective Chinese medicine formula for SAP treatment in China and has been used for many years. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110024DOI Listing

Ischemic reperfusion injury of renal transplant mimics acute rejection on renal scintigraphy in early post-operative period.

Urol Case Rep 2020 May 16;30:101122. Epub 2020 Jan 16.

Department of Radiology, King Faisal Specialist Hospital & Research Center, Riyadh, 11211, Saudi Arabia.

Renal scintigraphy of a renal graft is a non-invasive imaging used to evaluate renal graft dysfunction in relay postoperative period. We presented the case of a 42-year-old man when underwent renal transplantation and developed anuria with severe renal impairment. Renal scintigraphy yielded no visualization of the renal graft. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066220PMC

Aquaporin 1 alleviates acute kidney injury via PI3K-mediated macrophage M2 polarization.

Inflamm Res 2020 May 16;69(5):509-521. Epub 2020 Mar 16.

Department of Laboratory Diagnosis, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang, People's Republic of China.

Background: Lipopolysaccharide (LPS)-induced acute kidney injury (AKI) is associated with an abnormal immune response. Accumulating evidence has demonstrated that aquaporin 1 (AQP1) prevents kidney tissue injury in LPS-induced AKI by mediating immune response. However, the underlying mechanisms remain obscure. Read More

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http://dx.doi.org/10.1007/s00011-020-01334-0DOI Listing

Role of silymarin () in the prevention of colistin-induced acute nephrotoxicity in rats.

Drug Chem Toxicol 2020 Mar 16:1-8. Epub 2020 Mar 16.

Department of Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey.

Silymarin (Silybum marianum) has some protective effects against drug toxicity (cisplatin, acetaminophen, adriamycin, gentamicin etc.). Colistin is a strong antimicrobial, which is frequently used in the treatment of resistant gram-negative bacterial infections in recent years although it has nephrotoxic potential. Read More

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http://dx.doi.org/10.1080/01480545.2020.1733003DOI Listing

Identification of Factors Associated With Acute Tubular Necrosis Following Kidney Transplant in Northern Mexico: Increased Risk With Cold Ischemia After 8 Hours.

Transplant Proc 2020 May 11;52(4):1110-1117. Epub 2020 Mar 11.

Department of Health Research, Christus Muguerza Hospital, Chihuahua, Mexico.

Aim: To identify potential risk factors associated with the incidence of acute tubular necrosis (ATN) following kidney transplant in a sample of patients from northern Mexico.

Methods: Secondary analysis of data extracted from clinical files of patients who underwent a kidney transplant between 2000 and 2017 at Christus Muguerza Hospital in the city of Chihuahua. The final sample with complete data included 485 patients. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.02.007DOI Listing

Signaling through tumor necrosis receptor 2 induces stem cell marker in CD133 regenerating tubular epithelial cells in acute cell-mediated rejection of human renal allografts.

Am J Transplant 2020 Mar 13. Epub 2020 Mar 13.

Department of Medicine, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.

Tumor necrosis factor receptor 2 (TNFR2) is strongly upregulated on renal tubular epithelial cells by acute cell-mediated rejection (ACR. In human kidney organ culture, TNFR2 signaling both upregulates TNFR2 expression and promotes cell cycle entry of tubular epithelial cells. We find significantly more cells express CD133 mRNA and protein, a putative stem cell marker, in allograft biopsy samples with ACR compared to acute tubular injury without rejection or pretransplant "normal kidney" biopsy samples. Read More

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http://dx.doi.org/10.1111/ajt.15846DOI Listing

Microvasculature partial endothelial mesenchymal transition in early posttransplant biopsy with acute tubular necrosis identifies poor recovery renal allografts.

Am J Transplant 2020 Mar 13. Epub 2020 Mar 13.

Sorbonne Université, Institut national de la santé et de la recherche médicale (INSERM), Unité mixte de recherche (UMR), Paris, France.

Acute tubular necrosis (ATN), a frequent histopathological feature in the early post-renal transplant biopsy, affects long-term graft function. Appropriate markers to identify patients at risk of no or incomplete recovery after delayed graft function are lacking. In this study, we first included 41 renal transplant patients whose biopsy for cause during the first month after transplantation showed ATN lesions. Read More

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http://dx.doi.org/10.1111/ajt.15847DOI Listing

Nephrotoxicity of Antimicrobials and Antibiotics.

Adv Chronic Kidney Dis 2020 01;27(1):31-37

Icahn School of Medicine at Mount Sinai Beth Israel, New York, NY. Electronic address:

Medication-induced nephrotoxicity remains one of the most common causes of acute kidney injury (AKI) among hospitalized patients. Within the extensive group of medications associated with AKI, antibiotics and other antimicrobials are well recognized triggers of structural and functional renal impairment. Clinical manifestations range from mild forms of tubular injury to significant deterioration of kidney function requiring acute renal replacement therapy. Read More

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http://dx.doi.org/10.1053/j.ackd.2019.08.001DOI Listing
January 2020

Different roles of bortezomib and ONX 0914 in acute kidney injury.

Int Immunopharmacol 2020 Mar 3;82:106259. Epub 2020 Mar 3.

Department of Kidney Transplantation, Hospital of Nephropathy, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China; Institute of Organ Transplantation, Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address:

Proteasome inhibitor bortezomib offers one more option for acute or chronic antibody-mediated rejection after kidney transplantation, but aggravated acute kidney injury (AKI) in some cases early after surgery using bortezomib bring new problem. Here, we evaluated the effects of bortezomib and ONX-0914 on renal tubule injury in a mouse model of ischemia-reperfusion injury. After treated with bortezomib, serum creatinine, usea nitrogen and tubular necrosis significantly increased compared with vehicle-treated mice, but decreased in ONX-0914 group mildly. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106259DOI Listing

Ageing reduces angiotensin II type 1 receptor antagonism mediated pre-conditioning effects in ischemic kidneys by inducing oxidative and inflammatory stress.

Exp Gerontol 2020 Jul 28;135:110892. Epub 2020 Feb 28.

Cardiovascular-Renal Division, ISF College of Pharmacy, Moga, India.

Background: Ischemia/reperfusion (I/R) injury is a common cause of acute kidney injury (AKI), which occurs clinically during renal organ transplantation and major cardiac surgeries. Previously, it was demonstrated that angiotensin II type 1 receptor (AT) receptor antagonism is beneficial in the resolution of AKI episodes in young rats by reducing inflammation and oxidative stress. However, studies have shown that aged kidneys are refractory to surgical ischemic pre-conditioning due to increased oxidative stress, mitochondrial dysfunction, inflammation and apoptosis. Read More

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http://dx.doi.org/10.1016/j.exger.2020.110892DOI Listing

Rapidly Progressive Acute Kidney Injury Associated with Nivolumab Treatment.

Case Rep Oncol 2020 Jan-Apr;13(1):85-90. Epub 2020 Feb 6.

Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Okayama, Japan.

A 63-year-old man with pulmonary adenocarcinoma was treated with nivolumab. High fever developed within several hours after the first administration of nivolumab; subsequently, serum creatinine levels kept increasing daily. We diagnosed acute kidney injury (AKI) as an immune-related adverse event; the patient was initially treated with 50 mg prednisolone, and the dose was then tapered. Read More

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http://dx.doi.org/10.1159/000505235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036533PMC
February 2020

Chronic copper toxicosis in a crossbred heifer calf.

J Vet Diagn Invest 2020 May 28;32(3):458-462. Epub 2020 Feb 28.

Animal Disease Diagnostic Laboratory (Wong, Wilson-Frank, Hooser), College of Veterinary Medicine, Purdue University, West Lafayette, IN.

An 8-mo-old, crossbred, heifer calf was presented to the Heeke Animal Disease Diagnostic Laboratory with a history of ataxia and altered mentation. Grossly, the liver was diffusely yellow-orange, turgid, and exuded watery, thin blood on cut section. The cortex and medulla in both kidneys were diffusely and markedly dark brown to black. Read More

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http://dx.doi.org/10.1177/1040638720908229DOI Listing

ROS-responsive nano-drug delivery system combining mitochondria-targeting ceria nanoparticles with atorvastatin for acute kidney injury.

Theranostics 2020 16;10(5):2342-2357. Epub 2020 Jan 16.

Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, 866 Yu-Hang-Tang Road, Hangzhou, 310058, China.

Acute kidney injury (AKI) caused by sepsis is a serious disease which mitochondrial oxidative stress and inflammatory play a key role in its pathophysiology. Ceria nanoparticles hold strong and recyclable reactive oxygen species (ROS)-scavenging activity, have been applied to treat ROS-related diseases. However, ceria nanoparticles can't selectively target mitochondria and the ultra-small ceria nanoparticles are easily agglomerated. Read More

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http://dx.doi.org/10.7150/thno.40395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019163PMC
January 2020

Continuous renal replacement therapy in critically ill patients with acute on chronic liver failure and acute kidney injury: A retrospective cohort study
.

Clin Nephrol 2020 Apr;93(4):187-194

Background: Incident acute kidney injury (AKI) in critically ill patients with acute on chronic liver failure (ACLF) is associated with poor prognosis. The role of continuous renal replacement therapy (CRRT) is not well established for patients with ACLF and AKI.

Materials And Methods: We conducted a retrospective cohort study to examine clinical outcomes in 66 patients with ACLF and AKI requiring CRRT. Read More

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http://dx.doi.org/10.5414/CN109983DOI Listing

Molecular pathways driving omeprazole nephrotoxicity.

Redox Biol 2020 May 12;32:101464. Epub 2020 Feb 12.

Research Institute-Fundacion Jimenez Diaz, Autonoma University, Madrid, Spain; REDINREN, Madrid, Spain. Electronic address:

Omeprazole, a proton pump inhibitor used to treat peptic ulcer and gastroesophageal reflux disease, has been associated to chronic kidney disease and acute interstitial nephritis. However, whether omeprazole is toxic to renal cells is unknown. Omeprazole has a lethal effect over some cancer cells, and cell death is a key process in kidney disease. Read More

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http://dx.doi.org/10.1016/j.redox.2020.101464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038587PMC

Evaluation of Renal Disease in Patients With Cirrhosis.

J Clin Gastroenterol 2020 Apr;54(4):314-321

Department of Medicine, Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Renal dysfunction in cirrhosis is common and is associated with increased mortality. Identifying and treating reversible causes of renal disease can significantly improve outcomes. The etiology, approach, and evaluation of renal disease in this group of patients is similar to the noncirrhosis patient, with a few specific caveats. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001325DOI Listing

P2X4 receptor exacerbates ischemic AKI and induces renal proximal tubular NLRP3 inflammasome signaling.

FASEB J 2020 Apr 21;34(4):5465-5482. Epub 2020 Feb 21.

Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY, USA.

We tested the hypothesis that the P2X4 purinergic receptor (P2X4) exacerbates ischemic acute kidney injury (AKI) by promoting renal tubular inflammation after ischemia and reperfusion (IR). Supporting this, P2X4-deficient (KO) mice were protected against ischemic AKI with significantly attenuated renal tubular necrosis, inflammation, and apoptosis when compared to P2X4 wild-type (WT) mice subjected to renal IR. Furthermore, WT mice treated with P2X4 allosteric agonist ivermectin had exacerbated renal IR injury whereas P2X4 WT mice treated with a selective P2X4 antagonist (5-BDBD) were protected against ischemic AKI. Read More

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http://dx.doi.org/10.1096/fj.201903287RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136150PMC

Diabetes mellitus: a single cardiorenal syndrome umbrella.

Clin Kidney J 2020 Feb 26;13(1):14-16. Epub 2019 Nov 26.

Department of Nephrology, Hospital del Mar, Barcelona, Spain.

Diabetes and chronic kidney disease are among the fastest-growing causes of death worldwide. An optimized conceptual framework on the pathogenesis of diabetic kidney disease and its interplay with cardiovascular disease will facilitate the development of monitoring and therapeutic strategies to decrease the risk for severe clinical events and early mortality. In this issue of , Pinier . Read More

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http://dx.doi.org/10.1093/ckj/sfz161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025372PMC
February 2020