6,124 results match your criteria Acute Tubular Necrosis


Renal and Vascular Effects of Kallikrein Inhibition in a Model of Lonomia obliqua Venom-Induced Acute Kidney Injury.

PLoS Negl Trop Dis 2019 Feb 14;13(2):e0007197. Epub 2019 Feb 14.

Laboratório de Bioquímica Farmacológica, Centro de Pesquisa Experimental (CPE), Hospital de Clínicas de Porto Alegre (HCPA-UFRGS), Porto Alegre, RS, Brazil.

Background: Lonomia obliqua venom is nephrotoxic and acute kidney injury (AKI) is the main cause of death among envenomed victims. Mechanism underlying L. obliqua-induced AKI involves renal hypoperfusion, inflammation, tubular necrosis and loss of glomerular filtration and tubular reabsorption capacities. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007197DOI Listing
February 2019

Angiopoietin 1 influences ischemic reperfusion renal injury via modulating endothelium survival and regeneration.

Mol Med 2019 Feb 13;25(1). Epub 2019 Feb 13.

Department of Internal Medicine, National Taiwan University Hospital, No. 7, Jhong-Shan South Road, Taipei, 100, Taiwan.

Background: Damage to the endothelium due to ischemia reperfusion injury (IRI) leads to a disruption of the microvasculature, which could be influenced by angiopoietin 1 via its effects on endothelium. We investigated the physiological and therapeutic roles of angiopoietin 1 in renal IRI using angiopoietin 1 knockout and over-expression mice.

Methods: Renal IRI was induced by clamping the right renal artery seven days after left uninephrectomy for 25 min followed by reperfusion. Read More

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http://dx.doi.org/10.1186/s10020-019-0072-7DOI Listing
February 2019

Endocan as a marker of microvascular inflammation in kidney transplant recipients.

Sci Rep 2019 Feb 12;9(1):1854. Epub 2019 Feb 12.

Division of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea.

Endocan is a water-soluble proteoglycan exclusively secreted by vascular endothelium. Endocan levels may be elevated in kidney transplant recipients experiencing antibody-mediated rejection (ABMR), which is characterized by vascular inflammation in transplanted kidney. We evaluated the clinical relevance of endocan as markers of microvascular inflammation in patients who underwent kidney transplantation. Read More

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http://dx.doi.org/10.1038/s41598-018-37975-9DOI Listing
February 2019
1 Read

Association of hemophagocytic lymphohistiocytosis with kidney lesions in acute African swine fever virus infection

Ann Parasitol 2018 ;64(4):343-350

Department of Medical Biology and Parasitology, Armenia Yerevan State Medical University, 2 Koryun St., Yerevan 0025, Armenia

Glomerulonephritis due to African swine fever (ASF) is well documented. However, there is absence of good understanding of mechanisms involved in the development of pathology development. This study examines glomerulonephritis in association with acute infection induced by II genotype (Georgia 2007) of ASF virus. Read More

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January 2018
1 Read

The aqueous extract of aged black garlic ameliorates colistin-induced acute kidney injury in rats.

Ren Fail 2019 Nov;41(1):24-33

a Department of Internal Medicine , Gyeongsang National University Changwon Hospital , Changwon , Republic of Korea.

The use of colistin in the treatment of multidrug-resistant Gram-negative bacterial infections is restricted due to nephrotoxicity. We investigated the effects of aged black garlic extract (ABGE) on colistin-induced kidney injury in rats. Rats were assigned to four groups. Read More

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http://dx.doi.org/10.1080/0886022X.2018.1561375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366426PMC
November 2019
1 Read

The spectrum of kidney biopsy findings in patients with morbid obesity.

Kidney Int 2019 Jan 26. Epub 2019 Jan 26.

Department of Pathology and Cell Biology, Division of Renal Pathology, Columbia University Medical Center, New York, New York, USA. Electronic address:

Morbid obesity, defined as body mass index (BMI) ≥40 kg/m, affects approximately 8% of United States adults and is a recognized risk factor for chronic kidney disease (CKD). We present the first focused biopsy-based study exploring the range of kidney diseases in this population. Among 3263 native kidney biopsies interpreted at Columbia University in 2017, we identified 248 biopsies from morbidly obese patients. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.026DOI Listing
January 2019
1 Read

Malaria and acute kidney injury.

Pediatr Nephrol 2019 Jan 31. Epub 2019 Jan 31.

Department of Pediatric Nephrology at The Children's Hospital at Montefiore, 3326 Bainbridge Ave, Bronx, NY, 10029, USA.

Malaria is a parasitic infection transmitted by mosquitos, resulting in significant morbidity and mortality. It affects 212 million worldwide, causing death in up to 303,000 children annually. In the USA, up to 1700 people are affected yearly. Read More

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http://link.springer.com/10.1007/s00467-018-4191-0
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http://dx.doi.org/10.1007/s00467-018-4191-0DOI Listing
January 2019
3 Reads

Human proximal tubular cells can form calcium phosphate deposits in osteogenic culture: role of cell death and osteoblast-like transdifferentiation.

Cell Death Discov 2019 28;5:57. Epub 2019 Jan 28.

1Laboratory of Kidney Histomorphology and Molecular Biology, Clinical Nephrology, Department of Medicine-DIMED, University of Padova, Padova, Italy.

Nephrocalcinosis is a clinicopathological entity characterized by microscopic calcium crystals in the renal parenchyma, within the tubular lumen or in the interstitium. Crystal binding to tubular cells may be the cause underlying nephrocalcinosis and nephrolithiasis. Pathological circumstances, such as acute cortical necrosis, may induce healthy cells to acquire a crystal-binding phenotype. Read More

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http://dx.doi.org/10.1038/s41420-019-0138-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349935PMC
January 2019
2 Reads

The Effect of Overexpression of the Enhancer of Zeste Homolog 1 (EZH1) Gene on Aristolochic Acid-Induced Injury in HK-2 Human Kidney Proximal Tubule Cells In Vitro.

Med Sci Monit 2019 Jan 28;25:801-810. Epub 2019 Jan 28.

Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China (mainland).

BACKGROUND Acute kidney injury (AKI) involves the renal tubular epithelium. The enhancer of zeste homolog 1 (EZH1) gene has a role in cell development and differentiation. This study aimed to investigate the effect of overexpression of the EZH1 gene on aristolochic acid-induced injury in HK-2 human kidney proximal tubule epithelial cells in vitro. Read More

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http://dx.doi.org/10.12659/MSM.911611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362760PMC
January 2019
1 Read

Acute kidney injury in cirrhosis: implications for liver transplantation.

Curr Opin Crit Care 2019 Jan 22. Epub 2019 Jan 22.

Department of Critical Care Medicine.

Purpose Of Review: Acute kidney injury (AKI) in cirrhosis consists of varying phenotypes, with hepatorenal syndrome (HRS) representing a single entity. Prompt recognition and diagnosis of AKI cause identifies appropriate therapeutic measures. This review provides an overview of AKI definitions, highlights challenges in quantifying renal impairment in cirrhosis, lists novel diagnostic AKI biomarkers, and summarizes transplantation implications. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000590DOI Listing
January 2019
2 Reads

Hyperbilirubinemia Induces Pro-Apoptotic Effects and Aggravates Renal Ischemia Reperfusion Injury.

Nephron 2019 Jan 23:1-11. Epub 2019 Jan 23.

Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao,

Aims: Hyperbilirubinemia is associated with postoperative acute kidney injury in patients undergoing cardiac surgeries. A high concentration of bilirubin could induce oxidative stress and cell apoptosis. The aim of this study was to investigate whether hyperbilirubinemia aggravated the renal tubule cells injury and the pro-apoptotic potential of bilirubin on renal ischemia reperfusion injury (RIRI). Read More

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https://www.karger.com/Article/FullText/496066
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http://dx.doi.org/10.1159/000496066DOI Listing
January 2019
4 Reads

[Contrast induced nephropathy : myth or reality ?]

Rev Med Suisse 2019 Jan;15(635):206-210

Service de radiologie diagnostique et interventionnelle, Hôpital de La Tour, Avenue J.-D. Maillard, 1217 Meyrin.

Contrast induced nephropathy has long been considered as the third cause of inpatients acute renal insufficiency after functional renal insufficiency and acute tubular necrosis. This entity is now controversial. Numerous studies failed to show a direct link between intravenous iodinated contrast injection and a worsening of renal function after injected scanners in patients with normal renal function. Read More

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January 2019
5 Reads

S-allyl cysteine protects against lipopolysaccharide-induced acute kidney injury in the C57BL/6 mouse strain: Involvement of oxidative stress and inflammation.

Int Immunopharmacol 2019 Jan 18;69:19-26. Epub 2019 Jan 18.

Neurophysiology Research Center, Department of Physiology, Shahed University, Tehran, Iran. Electronic address:

Sepsis is a serious and life-threatening medical condition with a higher rate of patients' morbidity and mortality and with complications such as acute kidney injury (AKI). S-allyl cysteine (SAC) is the active constituent of the medicinal plant garlic (Allium sativum) with multiple beneficial effects including anti-inflammatory and antioxidant properties. In this research, we tried to determine the protective effect of SAC pretreatment in a mouse model of AKI. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.026DOI Listing
January 2019
3 Reads

Dexmedetomidine protects against lipopolysaccharide-induced early acute kidney injury by inhibiting the iNOS/NO signaling pathway in rats.

Nitric Oxide 2019 Jan 17;85:1-9. Epub 2019 Jan 17.

College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Northeast Agricultural University, Harbin, 150030, PR China. Electronic address:

Increasing evidence has demonstrated that dexmedetomidine (DEX) possesses multiple pharmacological actions. Herein, we explored the protective effect and potential molecular mechanism of DEX on lipopolysaccharide (LPS)-induced early acute kidney injury (AKI) from the perspective of antioxidant stress. We found that DEX (30 μg/kg, i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10898603183034
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http://dx.doi.org/10.1016/j.niox.2019.01.009DOI Listing
January 2019
8 Reads

Role of Blood Oxygen Level-dependent MRI in Differentiation of Acute Renal Allograft Dysfunction.

Indian J Nephrol 2018 Nov-Dec;28(6):441-447

Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Early graft dysfunction after renal transplantation manifests as acute rejection (AR) or acute tubular necrosis (ATN). Blood oxygen level-dependent (BOLD) magnetic resonance (MR) imaging is a noninvasive method of assessing tissue oxygenation, which may be useful for predicting acute allograft dysfunction. This was a prospective study involving 40 patients scheduled for renal transplantation from August 2012 to August 2014. Read More

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http://dx.doi.org/10.4103/ijn.IJN_43_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309386PMC
January 2019
1 Read

[Epidemiology of acute renal failure].

Nephrol Ther 2019 Jan 10. Epub 2019 Jan 10.

Service de néphrologie et réanimation médicale, CHU Gabriel-Montpied, 58, rue Montalembert, 63000 Clermont-Ferrand, France. Electronic address:

The acute renal failure is common in the hospitalized patients with the incidence is increasing. This results from the aging of the population and the widespread use of nephrotoxic therapies or diagnostic techniques. The acute renal failure is associated with an increased length of stay in hospital and the short and long-term mortality. Read More

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http://dx.doi.org/10.1016/j.nephro.2018.11.002DOI Listing
January 2019
1 Read

Furosemide Stress Test as a Predicting Biomarker for Delayed Graft Function in Kidney Transplantation.

Nephron 2019 Jan 11:1-13. Epub 2019 Jan 11.

Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Background: Delayed graft function (DGF) could worsen early and long-term outcomes of kidney transplantation (KT). DGF is caused by several pre-transplantation and perioperative factors in both donors and recipients. At present, there are no biomarkers or tests during the immediate post-KT period that can accurately predict the development of DGF. Read More

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http://dx.doi.org/10.1159/000495765DOI Listing
January 2019
1 Read

Using functional magnetic resonance imaging to evaluate an acute allograft rejection model in rats.

Magn Reson Imaging 2019 Jan 7;58:24-31. Epub 2019 Jan 7.

Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Institute of Urology, Capital Medical University, Beijing, China. Electronic address:

Purpose: To assess the longitudinal changes of allograft pathophysiology by intravoxel incoherent motion (IVIM) and blood oxygen level-dependent (BOLD) MRI in a rat model of acute renal allograft rejection.

Materials And Methods: Acute rejection (AR) was induced by transplantation of Dark Agouti donor kidneys into Lewis recipients (n = 18). A Lewis-Lewis rat syngeneically transplanted (sTX) model served as the control (n = 6). Read More

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http://dx.doi.org/10.1016/j.mri.2019.01.006DOI Listing
January 2019
1 Read
2.022 Impact Factor

Dipeptidyl peptidase-4 inhibitor teneligliptin accelerates recovery from cisplatin-induced acute kidney injury by attenuating inflammation and promoting tubular regeneration.

Nephrol Dial Transplant 2019 Jan 8. Epub 2019 Jan 8.

Department of Medicine IV, University Hospital Ludwig-Maximilians-Universität München, Munich, Germany.

Background: Cisplatin is an effective chemotherapeutic agent. However, acute kidney injury (AKI) and subsequent kidney function decline limits its use. Dipeptidyl peptidase-4 (DPP-4) inhibitor has been reported to attenuate kidney injury in some in vivo models, but the mechanisms-of-action in tubule recovery upon AKI remain speculative. Read More

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http://dx.doi.org/10.1093/ndt/gfy397DOI Listing
January 2019
2 Reads

Evaluation of the criteria of hepatorenal syndrome type of acute kidney injury in patients with cirrhosis admitted to ICU.

Scand J Gastroenterol 2018 Dec 8;53(12):1590-1596. Epub 2019 Jan 8.

a Department of Critical Care Medicine , Beijing Ditan Hospital, Capital Medical University , Beijing , PR China.

Introduction: Acute kidney injury (AKI) is a common and devastating complication in patients with cirrhosis. In 2015, the International Club of Ascites (ICA) proposed the definition of hepatorenal syndrome (HRS) type of AKI (HRS-AKI) in patients with cirrhosis. This study aims to evaluate the criteria of HRS-AKI in patients with cirrhosis admitted to ICU with regard to the prognosis. Read More

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http://dx.doi.org/10.1080/00365521.2018.1545423DOI Listing
December 2018
2 Reads

Acute kidney injury in childhood-onset nephrotic syndrome: Incidence and risk factors in hospitalized patients.

Kidney Res Clin Pract 2018 Dec 31;37(4):347-355. Epub 2018 Dec 31.

Department of Pediatrics, Seoul National University Hospital, Seoul, Korea.

Background: Nephrotic syndrome (NS) is the most common glomerulopathy in children. Acute kidney injury (AKI) is a common complication of NS, caused by severe intravascular volume depletion, acute tubular necrosis, interstitial nephritis, or progression of NS. However, the incidence and risk factors of childhood-onset NS in Korea are unclear. Read More

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http://www.krcp-ksn.org/journal/view.html?doi=10.23876/j.krc
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http://dx.doi.org/10.23876/j.krcp.18.0098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312784PMC
December 2018
5 Reads

Transvenous Renal Biopsy of Critically Ill Patients: Safety and Diagnostic Yield.

Crit Care Med 2019 Mar;47(3):386-392

Service de Médecine Intensive Réanimation, Institut de Cardiométabolisme et Nutrition (iCAN), Hôpital La Pitié-Salpêtrière, Sorbonne Université, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.

Objectives: Transvenous renal biopsy is an alternative way to obtain kidney samples from patients with bleeding risk factors (e.g., antiplatelet therapy and anticoagulation or coagulation disorders). Read More

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http://dx.doi.org/10.1097/CCM.0000000000003634DOI Listing
March 2019
2 Reads

Rasburicase induced severe hemolysis and methemoglobinemia in a Caucasian patient complicated by acute renal failure and ARDS.

Respir Med Case Rep 2019 23;26:142-145. Epub 2018 Dec 23.

Pulmonary and Critical Care Medicine, Marshall University School of Medicine, Huntington, WV, USA.

Rasburicase is a recombinant urate-oxidase enzyme and is a very important medication for tumor lysis syndrome. Methemoglobinemia and hemolysis are known side effects of rasburicase that result from oxidative stress caused by hydrogen peroxide, a byproduct generated during the breakdown of uric acid to allantoin. Patients with G6PD deficiency have a decreased tolerance to oxidative stress and are therefore at a greater risk of hemolysis and methemoglobinemia with rasburicase. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307101PMC
December 2018
1 Read

Ischemia reperfusion injury in kidney transplantation: A case report.

Medicine (Baltimore) 2018 Dec;97(52):e13650

Department of Nephrology, Dialysis and Transplantation, Clermont Ferrand, University Hospital, Clermont Ferrand, France.

Rationale: Kidney transplantation is considered the best treatment for patients with end stage renal disease. Ischemia- reperfusion injury (IRI) is an evitable event after deceased donor transplantation and influences short term and long term graft outcome. Few data on IRI's histology in the setting of kidney transplantation are available in the literature despite its frequency and its severity. Read More

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http://dx.doi.org/10.1097/MD.0000000000013650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314654PMC
December 2018
1 Read

[Expression and significance of c-FLIP protein in sepsis mice with acute kidney injury].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 12;30(12):1132-1136

Department of Intensive Care Unit, Ningbo First Hospital, Ningbo 315010, Zhejiang, China. Corresponding author: Zhu Jianhua, Email:

Objective: To observe the expression of cellular Fas-associated death domain-like interleukin-1β converting enzyme inhibit protein (c-FLIP) in sepsis mice with acute kidney injury (SAKI) and explore its significance.

Methods: Thirty male ICR mice were divided into the normal control group (Normal group), sham operation group (Sham group) and SAKI group by random number table method, with 10 mice in each group. The SAKI model of mice was established by cecal ligation and puncture (CLP); the Sham group was not ligated and the cecum was not punctured, and other surgical procedures were the same as the SAKI group; the Normal group did not experience any treatment. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.10.006DOI Listing
December 2018
1 Read

Kidney histopathology in lethal human sepsis.

Crit Care 2018 12 27;22(1):359. Epub 2018 Dec 27.

Department of Critical Care, University of Groningen, University Medical Center Groningen, P.O. 30.001, Hanzeplein 1, 9700 RB, Groningen, Netherlands.

Purpose: The histopathology of sepsis-associated acute kidney injury (AKI) in critically ill patients remains an understudied area. Previous studies have identified that acute tubular necrosis (ATN) is not the only driver of sepsis-AKI. The focus of this study was to identify additional candidate processes that may drive sepsis-AKI. Read More

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http://dx.doi.org/10.1186/s13054-018-2287-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307291PMC
December 2018
1 Read

Bile cast nephropathy causing acute kidney injury in a patient with nonfulminant acute hepatitis A.

Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1498-1501

Department of Nephrology, Kerala Institute of Medical Sciences, Thiruvananthapuram, Kerala, India.

Hepatitis A is usually a benign self-limiting disease with few or no extrahepatic manifestations. Acute hepatitis A causing severe renal dysfunction is not very common, although described. Patients developing renal dysfunction post hepatitis A infection usually have prerenal acute kidney injury (AKI) or acute tubular necrosis due to vomiting, diarrhea, and poor fluid replacement. Read More

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http://dx.doi.org/10.4103/1319-2442.248305DOI Listing
December 2018
1 Read

G6PD deficiency is not an uncommon cause of pigment nephropathy.

Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1371-1375

Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Acute kidney injury (AKI) with evidence of hemolysis is associated with tropical infections. However, pigment-induced AKI can happen with relatively uncommon genetic causes of hemolytic anemia, i.e. Read More

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http://www.sjkdt.org/text.asp?2018/29/6/1371/248316
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http://dx.doi.org/10.4103/1319-2442.248316DOI Listing
December 2018
11 Reads

Effect of Renal Diagnosis on Survival in Simultaneous Liver-Kidney Transplantation.

J Am Coll Surg 2018 Dec 23. Epub 2018 Dec 23.

Department of Surgery, Division of Abdominal Transplantation, University of Alabama at Birmingham, Birmingham, AL.

Background: Simultaneous liver-kidney transplantation is lifesaving, however, the utility of allocating 2 organs to a single recipient remains controversial, particularly in the face of potentially inferior survival. This study aims to determine the effect of renal indication for transplantation on simultaneous liver-kidney transplantation outcomes.

Methods: All adult recipients of combined whole liver-kidney transplants in the United Network for Organ Sharing database from 2003 to 2016 with a renal diagnosis of hypertension (HTN), diabetes mellitus (DM), acute tubular necrosis (ATN), or hepatorenal syndrome (HRS) were examined. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10727515183222
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http://dx.doi.org/10.1016/j.jamcollsurg.2018.12.003DOI Listing
December 2018
5 Reads

Secondary amyloidosis associated with heroin use and recurrent infections - A case report.

Authors:
Deepthi Mani

Ann Med Surg (Lond) 2019 Jan 22;37:38-41. Epub 2018 Nov 22.

Multi Care Good Samaritan Hospital, Puyallup, WA, USA.

A 49-year-old lady with history of polysubstance use disorder, recurrent cutaneous abscesses, spinal diskitis and septic thrombophlebitis presented to the emergency room with complaints of intermittent fevers, worsening right hip pain and bilateral lower extremity edema. A month before the presentation, she had left another hospital against medical advice after being diagnosed with Methicillin-resistant bacteremia and right hip septic arthritis. Post discharge, she was off antibiotics, but continued heroin and methamphetamine use. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S20490801183026
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http://dx.doi.org/10.1016/j.amsu.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297111PMC
January 2019
2 Reads

Sonography of the renal allograft: Correlation between doppler sonographic resistance index (RI) and histopathology.

Clin Hemorheol Microcirc 2018 Dec 12. Epub 2018 Dec 12.

Abteilung für Nephrologie, Klinikum rechts der Isar der Technischen Universität München, Germany.

Introduction: Allograft rejection (AR), chronic allograft injury (CAI) and acute tubular necrosis (ATN) can lead to renal allograft dysfunction after kidney transplantation. Interstitial fibrosis/tubular atrophy (Banff classification 2005) describes chronic allograft injury with no specific etiology, thus explaining the common final endpoint of various (immunologic and non immunologic) etiologies. The aim of this study was to evaluate correlations between the Doppler sonographic RI-values and histopathological changes of renal allografts biopsies during rejection, acute tubular necrosis and chronic allograft injury as well as the influence of donor and recipient features on the intrarenal RI-values. Read More

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http://dx.doi.org/10.3233/CH-189306DOI Listing
December 2018
2 Reads

Acute kidney injury due to thin basement membrane disease mimicking Deferasirox nephrotoxicity: a case report.

BMC Nephrol 2018 Dec 17;19(1):363. Epub 2018 Dec 17.

Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Background: Although the renal toxicity of Deferasirox, an oral iron chelator, has been reported to be mild, there have been reports of acute interstitial nephritis or Fanconi syndrome due to this agent. Thin basement membrane disease (TBMD) is a hereditary disease characterized primarily by hematuria, with gross hematuria also observed in about 7% of cases. We herein report a case of TBMD that presented with acute kidney injury and gross hematuria during treatment with Deferasirox. Read More

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http://dx.doi.org/10.1186/s12882-018-1180-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298017PMC
December 2018
2 Reads

Impact of Daily Electronic Laboratory Alerting on Early Detection and Clinical Documentation of Acute Kidney Injury in Hospital Settings.

Acad Pathol 2018 Jan-Dec;5:2374289518816502. Epub 2018 Dec 4.

Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.

Acute kidney injury, especially early-stage disease, is a common hospital comorbidity requiring timely recognition and treatment. We investigated the effect of daily laboratory alerting of patients at risk for acute kidney injury as measured by documented diagnoses. A quasi-experimental study was conducted at 8 New York hospitals between January 1, 2014, and June 30, 2017. Read More

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http://dx.doi.org/10.1177/2374289518816502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287301PMC
December 2018
2 Reads

Minimal Change Disease Associated with High-dose Aspirin.

Cureus 2018 Oct 4;10(10):e3408. Epub 2018 Oct 4.

Nephrology, North Florida Regional Medical Center, Gainesville, USA.

Minimal change disease (MCD) is an etiology of nephrotic syndrome that is more common in the pediatric population as compared to the adult population. Steroids are an effective treatment for MCD. Non-steroidal anti-inflammatory drugs (NSAIDS) are well known for their nephrotoxicity when used chronically. Read More

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http://dx.doi.org/10.7759/cureus.3408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284872PMC
October 2018

Biological alterations in renal and hepatic tissues by a novel gold (III) anti-cancerous compound.

Iran J Basic Med Sci 2018 Oct;21(10):1064-1072

Department of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Objectives: Newer organo-metallic, specifically gold (III) complexes with multiple ligands are currently being formulated with primary focus of having increased anti-cancerous properties and decreased cytotoxicity. In this study, histological toxicity profile of a newly formulated anti-cancerous gold (III) compound [trans-(±)-1,2-(DACH)Au]Cl Bis(trans-1,2-Diaminocyclohexane) was investigated by evaluation of kidney and liver tissues of rats treated by the compound.

Materials And Methods: This is a quasi-experimental study. Read More

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http://ijbms.mums.ac.ir/article_11334.html
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http://dx.doi.org/10.22038/IJBMS.2018.28622.6935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281062PMC
October 2018
8 Reads

MAGE genes in the kidney: identification of MAGED2 as upregulated during kidney injury and in stressed tubular cells.

Nephrol Dial Transplant 2018 Dec 11. Epub 2018 Dec 11.

Nephrology, IIS-Fundacion Jimenez Diaz-Universidad Autonoma de Madrid and Fundacion Renal Iñigo Alvarez de Toledo-IRSIN, Madrid, Spain.

Background: Mutations in Melanoma Antigen-encoding Gene D2 (MAGED2) promote tubular dysfunction, suggesting that MAGE proteins may play a role in kidney pathophysiology. We have characterized the expression and regulation of MAGE genes in normal kidneys and during kidney disease.

Methods: The expression of MAGE genes and their encoded proteins was explored by systems biology multi-omics (kidney transcriptomics and proteomics) in healthy adult murine kidneys and following induction of experimental acute kidney injury (AKI) by a folic acid overdose. Read More

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https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt
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http://dx.doi.org/10.1093/ndt/gfy367DOI Listing
December 2018
5 Reads
3.577 Impact Factor

Adipose tissue derived mesenchymal stem cell transplantation in the treatment of ischemia/reperfusion induced acute kidney injury in rats. Application route and therapeutic window1.

Acta Cir Bras 2018 Nov;33(11):1016-1026

Veterinay Medical, Animal Experimentation Division, Clinical Hospital, Universidade Federal do Rio Grande do Sul (UFRS), Porto Alegre-RS, Brazil. Substantive scientific and intellectual contributions to the study, critical revision.

Purpose: To evaluate renal repair in rats who had renal infarction induced by the obstruction of blood flow in the renal artery and were treated with transplantation of adipose tissue derived mesenchymal stem cell.

Methods: 16-week-old Wistar rats (n=72) were used, submitted to celiotomy and had of the renal artery and vein clipped for 24 hours. The animals were randomly assigned to 10 experimental homogeneous groups, corresponding to the treatments with phosphate-buffered saline (PBS) or adipose tissue derived mesenchymal stem cell (ADSC), duration of application (24 or 48 hours), and site of transplantation (lateral vein of the tail or intrarenal). Read More

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http://dx.doi.org/10.1590/s0102-865020180110000008DOI Listing
November 2018
2 Reads

The clinical and pathological significance of borderline T cell-mediated rejection.

Am J Transplant 2018 Nov 30. Epub 2018 Nov 30.

Department of Renal Medicine, Westmead Hospital, Sydney, Australia.

The pathological diagnosis of borderline rejection (BL-R) denotes possible T cell-mediated rejection (TCMR), but its clinical significance is uncertain. This single-center, cross-sectional cohort study compared the functional and histological outcomes of consecutive BL-R diagnoses (n = 146) against normal controls (n = 826) and acute TCMR (n = 55) from 551 renal transplant recipients. BL-R was associated with the following: contemporaneous renal dysfunction, acute tubular necrosis, and chronic tubular atrophy (P < . Read More

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http://dx.doi.org/10.1111/ajt.15197DOI Listing
November 2018
17 Reads

Reversible Acute Kidney Injury Associated with Sildenafil Overdose.

Cureus 2018 Sep 17;10(9):e3322. Epub 2018 Sep 17.

Internal Medicine, Florida Hospital, Orlando, USA.

Sildenafil is a phosphodiesterase type 5 inhibitor that is approved to treat erectile dysfunction and pulmonary hypertension. Generally, sildenafil is safe, with mild side effects. Here, we report a case of acute kidney injury caused by a sildenafil overdose. Read More

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https://www.cureus.com/articles/14120-reversible-acute-kidne
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http://dx.doi.org/10.7759/cureus.3322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248710PMC
September 2018
7 Reads

Pseudoginsengenin DQ Exhibits Therapeutic Effects in Cisplatin-Induced Acute Kidney Injury via Sirt1/NF-κB and Caspase Signaling Pathway without Compromising Its Antitumor Activity in Mice.

Molecules 2018 Nov 21;23(11). Epub 2018 Nov 21.

School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.

In this study, the protective effects of pseudoginsengenin DQ (PDQ) on cisplatin (CDDP)-induced nephrotoxicity were assessed, with a primary investigation into the mechanisms involved. Our results showed that pretreatment with PDQ remarkably restored levels of blood urea nitrogen (BUN) and creatinine (CRE), malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), tumor necrosis factor- (TNF-), and interleukin-1 (IL-1). Meanwhile, PDQ decreased the CDDP-induced overexpression of heme oxygenase 1 (HO-1), cytochrome P450 E1 (CYP2E1), TNF-, nuclear factor-kappa B (NF-κB), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) in renal tissues. Read More

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http://dx.doi.org/10.3390/molecules23113038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278544PMC
November 2018
9 Reads
2.416 Impact Factor

Extracellular traps in kidney disease.

Kidney Int 2018 Dec;94(6):1087-1098

Division of Nephrology, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Germany. Electronic address:

During the past decade the formation of neutrophil extracellular traps (NETs) has been recognized as a unique modality of pathogen fixation (sticky extracellular chromatin) and pathogen killing (cytotoxic histones and proteases) during host defense, as well as collateral tissue damage. Numerous other triggers induce NET formation in multiple forms of sterile inflammation, including thrombosis, gout, obstruction of draining ducts, and trauma. Whether neutrophils always die along with NET release, and if they do die, how, remains under study and is most likely context dependent. Read More

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http://dx.doi.org/10.1016/j.kint.2018.08.035DOI Listing
December 2018
8 Reads

Acute Kidney Injury Epidemiology in pediatrics.

J Bras Nefrol 2018 Nov 14. Epub 2018 Nov 14.

Universidade Federal de São Paulo, São Paulo, SP, Brasil.

We performed a search in the MEDLINE database using the MeSH term: "Acute Kidney Injury", selecting the subtopic "Epidemiology", and applying age and year of publication filters. We also searched for the terms: "acute renal failure" and "epidemiology" "acute tubular necrosis" and "epidemiology" in the title and summary fields with the same filters. In a second search, we searched in the LILACS database, with the terms: "acute renal injury", or "acute renal failure" or "acute kidney injury" and the age filter. Read More

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http://dx.doi.org/10.1590/2175-8239-JBN-2018-0127DOI Listing
November 2018
1 Read

Effects of subacute 3-monochloropropane-1,2-diol treatment on the kidney of male albino rats.

Biotech Histochem 2018 Nov 19:1-5. Epub 2018 Nov 19.

a Zoology Department, Faculty of Science , Ain Shams University , Cairo , Egypt.

3-Monochloropropane-1,2-diol (3-MCPD) is a well-known food contaminant. Although the kidney is thought to be a target organ for 3-MCPD toxicity, nephrotoxic structural changes are relatively unstudied. We investigated the renal alterations caused by 3-MCPD in male albino rats. Read More

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https://www.tandfonline.com/doi/full/10.1080/10520295.2018.1
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http://dx.doi.org/10.1080/10520295.2018.1543894DOI Listing
November 2018
20 Reads

The Atypical Chemokine Receptor 2 Limits Progressive Fibrosis after Acute Ischemic Kidney Injury.

Am J Pathol 2019 Feb 16;189(2):231-247. Epub 2018 Nov 16.

Division of Nephrology, Department of Medicine IV, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address:

Following renal ischemia-reperfusion injury (IRI), resolution of inflammation allows tubular regeneration, whereas ongoing inflammatory injury mediated by infiltrating leukocytes leads to nephron loss and renal fibrosis, typical hallmarks of chronic kidney disease. Atypical chemokine receptor 2 (ACKR2) is a chemokine decoy receptor that binds and scavenges inflammatory CC chemokines and reduces local leukocyte accumulation. We hypothesized that ACKR2 limits leukocyte infiltration, inflammation, and fibrotic tissue remodeling after renal IRI, thus preventing progression to chronic kidney disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029440173114
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http://dx.doi.org/10.1016/j.ajpath.2018.09.016DOI Listing
February 2019
15 Reads

The Prevention and Management of Contrast-induced Acute Kidney Injury: A Mini-review of the Literature.

Cureus 2018 Sep 11;10(9):e3284. Epub 2018 Sep 11.

Internal Medicine, CMH Lahore Medical College and Institute of Dentistry, Lahore, PAK.

Contrast-induced acute kidney injury, also called contrast-induced nephropathy, is one of the main causes of acute renal failure/acute kidney injury (AKI) in hospitalized patients within 48 to 72 hours of contrast media administration during various radiologic procedures. Several factors can be responsible for contrast-induced acute tubular necrosis (ATN); however, patient and procedure-related factors play the lead role in determining the development of contrast-induced nephropathy. There is no definitive treatment and hydration remains the mainstay preventive strategy. Read More

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https://www.cureus.com/articles/14849-the-prevention-and-man
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http://dx.doi.org/10.7759/cureus.3284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235634PMC
September 2018
10 Reads

Oral acyclovir induced hypokalemia and acute tubular necrosis a case report.

BMC Nephrol 2018 Nov 14;19(1):324. Epub 2018 Nov 14.

Servicio de Nefrología, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico.

Background: Acyclovir is one of the most common prescribed antiviral drugs. Acyclovir nephrotoxicity occurs in approximately 12-48% of cases. It can present in clinical practice as acute kidney injury (AKI), crystal-induced nephropathy, acute tubulointerstitial nephritis, and rarely, as tubular dysfunction. Read More

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http://dx.doi.org/10.1186/s12882-018-1121-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236899PMC
November 2018
2 Reads

Urinary angiotensinogen as a biomarker for acute to chronic kidney injury transition - prognostic and mechanistic implications.

Clin Sci (Lond) 2018 Nov 13;132(21):2383-2385. Epub 2018 Nov 13.

Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, U.K.

Accurate biomarkers that both predict the progression to, and detect the early stages of chronic kidney disease (CKD) are lacking, resulting in difficulty in identifying individuals who could potentially benefit from targeted intervention. In a recent issue [ (2018) , 2121-2133], Cui et al. examine the ability of urinary angiotensinogen (uAGT) to predict the progression of acute kidney injury (AKI) to CKD. Read More

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http://dx.doi.org/10.1042/CS20180795DOI Listing
November 2018
2 Reads

SCUBE1-enhanced bone morphogenetic protein signaling protects against renal ischemia-reperfusion injury.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 7;1865(2):329-338. Epub 2018 Nov 7.

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Ph.D. Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taiwan. Electronic address:

We previously reported that the membrane-bound SCUBE1 (signal peptide-CUB-epithelial growth factor domain-containing protein 1) forms a complex with bone morphogenetic protein 2 (BMP2) ligand and its receptors, thus acting as a BMP co-receptor to augment BMP signal activity. However, whether SCUBE1 can bind to and facilitate signaling activity of BMP7, a renal protective molecule for ischemia-reperfusion (I/R) insult, and contribute to the proliferation and repair of renal tubular cells after I/R remains largely unknown. In this study, we first showed that I/R-induced SCUBE1 was expressed in proximal tubular cells, which coincided with the expression of renoprotective BMP7. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09254439183044
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http://dx.doi.org/10.1016/j.bbadis.2018.10.038DOI Listing
February 2019
6 Reads

γ-secretase inhibitor DAPT mitigates cisplatin-induced acute kidney injury by suppressing Notch1 signaling.

J Cell Mol Med 2019 Jan 8;23(1):260-270. Epub 2018 Nov 8.

Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.

Organ toxicity, including kidney injury, limits the use of cisplatin for the treatment of multiple human cancers. Hence, interventions to alleviate cisplatin-induced nephropathy are of benefit to cancer patients. Recent studies have demonstrated that pharmacological inhibition of the Notch signaling pathway enhances cisplatin efficacy against several cancer cells. Read More

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http://doi.wiley.com/10.1111/jcmm.13926
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http://dx.doi.org/10.1111/jcmm.13926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307805PMC
January 2019
3 Reads

STAT1 regulates macrophage number and phenotype and prevents renal fibrosis after ischemia-reperfusion injury.

Am J Physiol Renal Physiol 2019 Feb 7;316(2):F277-F291. Epub 2018 Nov 7.

Department of Nephrology, Klinikum Rechts der Isar, Technical University of Munich , Munich , Germany.

Renal ischemia-reperfusion injury (IRI) leads to acute kidney injury or delayed allograft function, which predisposes to fibrosis in the native kidney or kidney transplant. Here we investigated the role of the signal transducer and activator of transcription 1 (STAT1) in inflammatory responses following renal IRI. Our study showed that a subsequent stimulation of Janus-activated kinase 2/STAT1 and Toll-like receptor 4 pathways led to greater STAT1 activation followed by increased cytokine transcription compared with single-pathway stimulation in murine renal tubular cells. Read More

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https://www.physiology.org/doi/10.1152/ajprenal.00004.2018
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http://dx.doi.org/10.1152/ajprenal.00004.2018DOI Listing
February 2019
11 Reads