6,166 results match your criteria Acute Tubular Necrosis


Regulated necrosis in kidney ischemia-reperfusion injury.

Kidney Int 2019 Mar 7. Epub 2019 Mar 7.

Immunology Research Centre, St. Vincent's Hospital Melbourne, Fitzroy, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia. Electronic address:

Ischemia-reperfusion injury (IRI) is the outcome of an inflammatory process that is triggered when an organ undergoes a transient reduction or cessation of blood flow, followed by re-establishment of perfusion. In the clinical setting, IRI contributes to significant acute kidney injury, patient morbidity and mortality, and adverse outcomes in transplantation. Tubular cell death by necrosis and apoptosis is a central feature of renal IRI. Read More

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http://dx.doi.org/10.1016/j.kint.2019.02.009DOI Listing
March 2019
1 Read

Nephroprotective Effect of Embryonic Stem Cells Reducing Lipid Peroxidation in Kidney Injury Induced by Cisplatin.

Oxid Med Cell Longev 2019 14;2019:5420624. Epub 2019 Mar 14.

Escuela Militar de Medicina, Centro Militar de Ciencias de la Salud, Secretaria de la Defensa Nacional, Ciudad de México 11200, Mexico.

Introduction: The acute kidney injury (AKI) is characterized by a sudden glomerular filtration reduction. Renal or intrinsic causes of AKI include nephrotoxicity induced by exogenous agents like cisplatin, which causes oxidative stress altering the biochemical process and leading to apoptosis. Therefore, this research is aimed at analyzing the embryonic stem cells (ESC) nephroprotective effect in AKI induced by cisplatin, employing genetic, phenotypic, and microspectroscopic techniques. Read More

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http://dx.doi.org/10.1155/2019/5420624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437739PMC
March 2019
3 Reads

Hepatorenal Syndrome.

Clin J Am Soc Nephrol 2019 Apr 17. Epub 2019 Apr 17.

Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California

Hepatorenal syndrome is a severe complication of end-stage cirrhosis characterized by increased splanchnic blood flow, hyperdynamic state, a state of decreased central volume, activation of vasoconstrictor systems, and extreme kidney vasoconstriction leading to decreased GFR. The contribution of systemic inflammation, a key feature of cirrhosis, in the development of hepatorenal syndrome has been highlighted in recent years. The mechanisms by which systemic inflammation precipitates kidney circulatory changes during hepatorenal syndrome need to be clarified. Read More

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.12451018
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http://dx.doi.org/10.2215/CJN.12451018DOI Listing
April 2019
2 Reads

Renal histopathology of prolonged acute kidney injury in HELLP syndrome: a case series and literature review.

Int Urol Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuifuyuan 1, Wangfujing, Beijing, 100730, China.

Purpose: Acute kidney injury (AKI) is a severe complication of hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. However, renal pathological investigation of AKI in this syndrome has rarely been reported. We aimed to evaluate the renal pathological changes of persistent AKI and its relationship with renal outcomes in HELLP syndrome. Read More

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http://dx.doi.org/10.1007/s11255-019-02135-zDOI Listing
April 2019
1 Read

Bone Marrow Derived Mesenchymal Stromal Cells Ameliorate Ischemia/Reperfusion Injury-Induced Acute Kidney Injury in Rats via Secreting Tumor Necrosis Factor-Inducible Gene 6 Protein.

Biomed Res Int 2019 11;2019:9845709. Epub 2019 Mar 11.

Department of Nephrology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.

Aims: To investigate whether bone marrow derived mesenchymal stromal cells (BMSC) have ameliorated ischemia/reperfusion injury-induced acute kidney injury (IRI-AKI) via tumor necrosis factor-inducible gene 6 protein (TSG-6) and how TSG-6 exerted this effect.

Methods: We used lentiviral vectors of short hairpin RNA (shRNA) targeting TSG-6 gene to silence TSG-6 in BMSC. And TSG-6-silenced BMSC were administrated into IRI-AKI rats. Read More

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https://www.hindawi.com/journals/bmri/2019/9845709/
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http://dx.doi.org/10.1155/2019/9845709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432703PMC
March 2019
1 Read

Apoptosis repressor with caspase recruitment domain deficiency accelerates ischemia/reperfusion (I/R)-induced acute kidney injury by suppressing inflammation and apoptosis: The role of AKT/mTOR signaling.

Biomed Pharmacother 2019 Apr 1;112:108681. Epub 2019 Mar 1.

Department of nephropathy, Wenling First People's Hospital, Wenling, 317500, China.

Acute kidney injury (AKI) is a significant medical problem worldwide. Ischemia-reperfusion (I/R) injury of the kidney is a major cause of AKI. However, the pathogenesis that contributes to renal I/R injury is still unclear. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108681DOI Listing
April 2019
1 Read

Macrophage migration inhibitory factor promotes renal injury induced by ischemic reperfusion.

J Cell Mol Med 2019 Apr 9. Epub 2019 Apr 9.

Department of Medicine and Therapeutics, Department of Anatomical and Cellular Pathology, Li Ka Shing Institute of Health Sciences, the Chinese University of Hong Kong, Hong Kong, China.

Macrophage migration inhibitory factor (MIF) is pleiotropic cytokine that has multiple effects in many inflammatory and immune diseases. This study reveals a potential role of MIF in acute kidney injury (AKI) in patients and in kidney ischemic reperfusion injury (IRI) mouse model in MIF wild-type (WT) and MIF knockout (KO) mice. Clinically, plasma and urinary MIF levels were largely elevated at the onset of AKI, declined to normal levels when AKI was resolved and correlated tightly with serum creatinine independent of disease causes. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14234
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http://dx.doi.org/10.1111/jcmm.14234DOI Listing
April 2019
4 Reads

Deceased Donor Renal Transplantation Combined with Bilateral Nephrectomy in a Patient with Tuberous Sclerosis and Renal Failure.

Case Rep Transplant 2019 6;2019:2172163. Epub 2019 Mar 6.

Transplant Surgery Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

Introduction: A 27-year-old female patient with known tuberous sclerosis complex (TSC), polycystic kidneys with multiple large bilateral angiomyolipomas, and failing renal functions with prehemodialysis values (urea: 19 mmol/L; creatinine: 317 mol/L; CKD-EPI 0,27) was admitted to our department for pre-renal transplant evaluation. The patient was placed on the transplant waiting list as the living donor did not pass pretransplant workup and was subsequently contraindicated. Patient was placed on the "cadaverous kidney transplant waiting list". Read More

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http://dx.doi.org/10.1155/2019/2172163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431358PMC
March 2019
1 Read

Peptidyl arginine deiminase-4 exacerbates ischemic AKI by finding NEMO (NFκB Essential Modulator).

Am J Physiol Renal Physiol 2019 Apr 3. Epub 2019 Apr 3.

Anesthesiology, Columbia University, United States.

Peptidyl arginine deiminase-4 (PAD4) catalyzes the conversion of peptidylarginine residues to peptidylcitrulline. We previously showed that kidney ischemia and reperfusion (IR) injury increases renal proximal tubular PAD4 expression and activity. Furthermore, kidney PAD4 plays a critical role in ischemic acute kidney injury (AKI) injury by promoting renal tubular inflammation, neutrophil infiltration and NFκB activation. Read More

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http://dx.doi.org/10.1152/ajprenal.00089.2019DOI Listing
April 2019
2 Reads

When acute kidney injury in the intensive care unit is not acute tubular necrosis: A case report of κ-light chain crystalline tubulopathy
.

Clin Nephrol 2019 May;91(5):311-316

Introduction: This case highlights the importance of getting a thorough workup for acute kidney injury before assigning a diagnosis.

Case Presentation: A 68-year-old male was referred to our clinic after a recent outside hospitalization for septic knee arthritis and acute kidney injury requiring hemodialysis. He had chronic kidney disease presumed secondary to diabetes with baseline GFR 50 mL/min. Read More

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http://dx.doi.org/10.5414/CN109693DOI Listing
May 2019
2 Reads

Kidney disease in africans with hiv and tuberculosis.

AIDS 2019 Mar 19. Epub 2019 Mar 19.

King's College London, London, UK.

Objective: To describe the spectrum of kidney disease in African patients with HIV and tuberculosis (TB).

Methods: We used data from three cohorts: consecutive patients with HIV/TB in South London (UK, 2004-2016; n = 95), consecutive patients with HIV/TB who underwent kidney biopsy in Cape Town (South Africa, 2014-2017; n = 70), and consecutive patients found to have HIV/TB on autopsy in Abidjan (Cote d'Ivoire, 1991; n = 100). Acute kidney injury (AKI) was ascertained using the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002204DOI Listing
March 2019
3 Reads

Nivolumab-induced hepatitis: A rare side effect of an immune check point inhibitor.

J Oncol Pharm Pract 2019 Mar 25:1078155219837342. Epub 2019 Mar 25.

2 Saint Francis Hospital and Medical Center, Hartford, CT, USA.

Immune checkpoint inhibitors have ushered in a new era in cancer management. Nivolumab is a human immunoglobulin G4 (IgG4) monoclonal antibody that selectively inhibits programmed cell death-1 (PD-1) activity by binding to the PD-1 receptor. This inhibits suppression of the T-cell activity, which can in turn cause increased killing of cancer cells. Read More

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http://dx.doi.org/10.1177/1078155219837342DOI Listing
March 2019
8 Reads

Regulated necrosis and failed repair in cisplatin-induced chronic kidney disease.

Kidney Int 2019 Apr;95(4):797-814

Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; Department of Medicine, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA. Electronic address:

Cisplatin is an effective chemotherapeutic agent, but significant nephrotoxicity limits its clinical use. Despite extensive investigation of the acute cellular and molecular responses to cisplatin, the mechanisms of progression from acute to chronic kidney injury have not been explored. We used functional and morphological metrics to establish a time-point when the transition from acute and reversible kidney injury to chronic and irreparable kidney disease is clearly established. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.042DOI Listing
April 2019
1 Read
8.563 Impact Factor

Spectrum of acute kidney injury associated with cocaine use: report of three cases.

BMC Nephrol 2019 Mar 20;20(1):99. Epub 2019 Mar 20.

Medical Sciences Postgraduate Program, Department of Internal Medicine, School of Medicine, Estadual University of Ceará, Fortaleza, Brazil.

Background: The consequences of cocaine use are multisystemic, such as, for instance, renal failure, hepatotoxicity and pulmonary toxicity, with renal alterations being the focus of the present study. The use of substances that modify the base composition of cocaine (or adulterants) aiming to potentiate its effects also has an impact on these manifestations. The present study aims to report three cases with different diagnosis of acute kidney injury related to cocaine use. Read More

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http://dx.doi.org/10.1186/s12882-019-1279-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427899PMC
March 2019
3 Reads

Effect of levosimendan, a calcium sensitizer, on cisplatin-induced nephrotoxicity in rats.

Toxicol Rep 2019 25;6:232-238. Epub 2019 Feb 25.

Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, Al- Khod, Oman.

We investigated the effect of levosimendan on cisplatin (Cis)-induced nephrotoxicity. Rats were divided into four groups (n = 6). The first and second groups received normal saline (control) and intraperitoneal (i. Read More

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http://dx.doi.org/10.1016/j.toxrep.2019.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402298PMC
February 2019
1 Read

Increased Intra-abdominal Pressure Induces Acute Kidney Injury in an Experimental Model of Congestive Heart Failure.

J Card Fail 2019 Mar 14. Epub 2019 Mar 14.

Department of Physiology, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology; Department of Laboratory Medicine, Rambam Health Care Campus, Haifa, Israel. Electronic address:

Background: Congestive heart failure (CHF) entails a complex interaction between the heart and the kidney that represents a clinical entity called cardiorenal syndrome (CRS). One of the mechanisms underlying CRS includes increased intra-abdominal pressure (IAP). We examined the effect of elevated IAP on kidney function in rats with low- and high-output CHF. Read More

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http://dx.doi.org/10.1016/j.cardfail.2019.03.008DOI Listing
March 2019
2 Reads

Wasp venom and acute kidney injury: The mechanisms and therapeutic role of renal replacement therapy.

Toxicon 2019 May 14;163:1-7. Epub 2019 Mar 14.

Department of Nephrology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, 441000, Hubei, China. Electronic address:

Stinging accidents involving wasp venom are a notable cause of acute kidney injury (AKI) in Asia. However, very little attention has been paid to the understanding of the mechanisms involved in this type of AKI. The aims of this review are to explore the evidence for the mechanisms and the therapeutic role of renal replacement therapy of wasp venom and AKI. Read More

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http://dx.doi.org/10.1016/j.toxicon.2019.03.008DOI Listing
May 2019
2 Reads

Usefulness of Delayed Introduction of Tacrolimus in Kidney Transplants Using Type-III Donors After Circulatory Death.

Transplant Proc 2019 Mar 29;51(2):337-340. Epub 2018 Oct 29.

Nephrology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.

Introduction: Our study compares 2 immunosuppressive strategies to reduce tacrolimus nephrotoxicity and its risk of acute tubular necrosis: delayed introduction of tacrolimus plus thymoglobulin vs initial tacrolimus plus basiliximab on the results of kidney transplant (KT) using type-III donation after circulatory death (III-DCD).

Material And Methods: We analyzed all the transplants performed using type-III DCD in our hospital (42 cases). They were distributed in a first stage with delayed tacrolimus (3°-4° day) + thymoglobulin and a second one with initial tacrolimus + basiliximab, with a follow-up of 6 months. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.10.022DOI Listing
March 2019
1 Read

Utility of Basal Regional Oximetry Saturation for the Diagnosis of Acute Tubular Necrosis in the Early Postoperative Period Following Kidney Transplantation.

Transplant Proc 2019 Mar 13;51(2):328-333. Epub 2018 Dec 13.

Intensive Care Medicine Department, University Hospital Infanta Cristina, University of Extremadura (UEX), Badajoz, Spain.

Introduction: Adequate perfusion and oxygenation to a renal graft after transplantation are essential for its viability. Regional renal oximetry (RSrO) through near-infrared spectroscopy shows real-time oxygen content of the graft.

Methods: A prospective study was conducted. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.12.011DOI Listing
March 2019
1 Read

Impact of Pulmonary Exposure to Cerium Oxide Nanoparticles on Experimental Acute Kidney Injury.

Cell Physiol Biochem 2019 15;52(3):439-454. Epub 2019 Mar 15.

Department of Pharmacology, College of Medicine & Health Sciences, Sultan Qaboos University, Al-Khod, Sultanate of Oman.

Background/aims: Cerium oxide nanoparticles (CeO₂ NPs) are released from diesel engines that use cerium compounds as a catalytic agent to decrease the diesel exhaust particles, leading to human exposure by inhalation to CeO₂ NPs. We have recently demonstrated that pulmonary exposure to CeO₂ NPs induces lung inflammation, thrombosis, and oxidative stress in various organs including kidneys. It is well known that particulate air pollution effects are greater in patients with renal diseases. Read More

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https://www.cellphysiolbiochem.com/Articles/000032/
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http://dx.doi.org/10.33594/000000032DOI Listing
March 2019
5 Reads
2.875 Impact Factor

Chrysin protects against renal ischemia reperfusion induced tubular cell apoptosis and inflammation in mice.

Exp Ther Med 2019 Mar 21;17(3):2256-2262. Epub 2019 Jan 21.

Department of Urology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei 441021, P.R. China.

Renal ischemia reperfusion (IR) is a major cause of acute kidney injury with no effective treatment. Chrysin is an anti-inflammatory, anti-oxidant and anti-cancer agent. However, the effect of chrysin on renal IR injury remains unknown. Read More

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http://dx.doi.org/10.3892/etm.2019.7189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395967PMC
March 2019
1 Read

Review of the many faces of synthetic cannabinoid toxicities.

Ment Health Clin 2019 Mar 1;9(2):93-99. Epub 2019 Mar 1.

Pharmacy Librarian, Marshall B. Ketchum University, MB Ketchum Memorial Library, Fullerton, California.

Introduction: Synthetic cannabinoids (SCs) are psychoactive substances that are gaining popularity for their availability and lack of detection by standardized drug tests. Although some users may perceive SCs as safer alternatives to marijuana, some SCs are more potent and result in more severe toxicities.

Methods: A search of the literature was conducted in the PubMed and SciFinder databases. Read More

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http://dx.doi.org/10.9740/mhc.2019.03.093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398358PMC
March 2019
2 Reads

Modulation of Renal Parenchyma in Response to Allogeneic Adipose-Derived Mesenchymal Stem Cells Transplantation in Acute Kidney Injury.

Int J Stem Cells 2019 Mar;12(1):125-138

Department of Urology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan.

Background And Objectives: In regenerative medicine, mesenchymal stem cells derived from adipose tissues (Ad-MSCs) are a very attractive target to treat many diseases. In relation to nephrology, the aim of the current study is to investigate the effects of Ad-MSCs for the amelioration of acute kidney injury and to explore the mechanism of renal parenchymal changes in response to allogeneic transplantation of Ad-MSCs.

Methods And Results: The nephrotoxicity was induced by cisplatin (CP) in balb/c mice according to RIFLE Class and AKIN Stage 3. Read More

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http://dx.doi.org/10.15283/ijsc18091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457705PMC
March 2019
4 Reads

Histopathology and Long-Term Outcome of Kidneys Transplanted From Donors With Severe Acute Kidney Injury.

Prog Transplant 2019 Mar 13;29(1):36-42. Epub 2018 Dec 13.

1 Department of Diagnostics and Public Health, Pathology Unit, University and Hospital Trust of Verona, Verona, Italy.

Background:: Acute kidney injury is a treatable entity although difficult to recognize without diagnostic biopsy. We investigated the potential association between clinically defined deceased donors and acute kidney injury with preimplantation histological findings and recipient outcomes.

Methods:: Kidney biopsies from donors were classified using the Acute Kidney Injury Network criteria and assessed for percentage glomerulosclerosis, tubular atrophy, interstitial fibrosis, and vascular narrowing with the Remuzzi score and for acute tubular necrosis. Read More

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http://dx.doi.org/10.1177/1526924818817054DOI Listing
March 2019
5 Reads

A case of biopsy-proven oxaliplatin-induced acute tubulointerstitial nephritis with thrombocytopenia and anemia.

CEN Case Rep 2019 Mar 2. Epub 2019 Mar 2.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, Kawasaki, 216-8511, Japan.

Oxaliplatin, a third-generation platinum agent, has been used for the treatment of colon, pancreatic, and stomach cancers in recent years. It carries a reduced risk of acute kidney injury (AKI) compared to the previous platinum agents, including cisplatin and carboplatin. Several cases of oxaliplatin-induced acute tubular necrosis (ATN) have been reported; however, only one case has been reported as acute tubulointerstitial nephritis (ATIN) histopathologically. Read More

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http://dx.doi.org/10.1007/s13730-019-00390-8DOI Listing
March 2019
3 Reads

Protective effects of anthocyanins from bilberry extract in rats exposed to nephrotoxic effects of carbon tetrachloride.

Chem Biol Interact 2019 May 27;304:61-72. Epub 2019 Feb 27.

Department of Biochemistry, Faculty of Medicine, University of Niš, Bulevar dr Zorana Đinđića 81, 18000, Niš, Serbia.

This study examined the nephroprotective effects of 15 different anthocyanins from the bilberry extract on the acute kidney injury caused by CCl. The acute nephrotoxicity in rats was induced 24 h after the treatment with a single dose of CCl (3 mL/kg, i.p. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.02.022DOI Listing
May 2019
7 Reads

Drug-induced tubulointerstitial nephritis: hypersensitivity and necroinflammatory pathways.

Authors:
Allison A Eddy

Pediatr Nephrol 2019 Feb 28. Epub 2019 Feb 28.

Department of Pediatrics, University of British Columbia and BC Children's Hospital Research Institute, Vancouver, Canada.

More than 250 drugs carry a small but important dose-independent risk of initiating a delayed-type hypersensitivity reaction that leads to acute tubulointerstitial nephritis (TIN). Clinical manifestations are often non-specific, making epidemiological studies challenging. In severe cases, if cessation of the offending drug is not followed by a prompt improvement in renal function, corticosteroid therapy appears to enhance renal recovery rates. Read More

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http://link.springer.com/10.1007/s00467-019-04207-9
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http://dx.doi.org/10.1007/s00467-019-04207-9DOI Listing
February 2019
6 Reads

EZH2 plays a crucial role in ischemia/reperfusion-induced acute kidney injury by regulating p38 signaling.

Inflamm Res 2019 Apr 28;68(4):325-336. Epub 2019 Feb 28.

Department of Anesthesiology, Affiliated Foshan Hospital of Sun Yat-sen University, Foshan, 528000, China.

Objective And Design: Renal ischemia-reperfusion (IR)-induced acute kidney injury (AKI) remains a major challenge in clinic. The histone methyltransferases enhancer of zest homolog-2 (EZH2) is associated with the development of renal injury. However, the molecular mechanism has not been fully elucidated. Read More

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http://dx.doi.org/10.1007/s00011-019-01221-3DOI Listing
April 2019
4 Reads
2.143 Impact Factor

Missed Monoclonal Disease Manifesting in Early Post-renal Transplant Period.

Indian J Nephrol 2019 Jan-Feb;29(1):65-69

Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

A 63-year-old diabetic gentleman with microvascular complications presented with advanced azotemia and anemia. He was stabilized with blood transfusion and hemodialysis. With the probable diagnosis of diabetic nephropathy-related end-stage renal disease, he underwent kidney transplantation. Read More

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http://dx.doi.org/10.4103/ijn.IJN_384_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375021PMC

Neutrophil gelatinase-associated lipocalin for assessment of acute kidney injury in cirrhosis. A prospective study.

Hepatology 2019 Feb 27. Epub 2019 Feb 27.

Liver Unit, Hospital Clínic, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Catalonia, Spain.

Background/aims: Kidney biomarkers appear to be useful in differential diagnosis between Acute Tubular Necrosis (ATN) and other types of AKI in cirrhosis, particularly hepatorenal syndrome (HRS-AKI). Distinction is important because treatment is different. However, kidney biomarkers are still not used in clinical practice. Read More

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http://dx.doi.org/10.1002/hep.30592DOI Listing
February 2019
1 Read

Snake bite-induced renal medullary angitiis in a child: A case report.

Saudi J Kidney Dis Transpl 2019 Jan-Feb;30(1):231-234

Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Snake bite envenomation is common in tropical countries during the summer. Snake bite-induced acute kidney injury (AKI) has varied histopathological manifestations such as acute cortical necrosis, acute tubular necrosis (ATN), and acute interstitial nephritis. However, snake bite-induced renal medullary angiitis has rarely been reported. Read More

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February 2019
1 Read

[Acute kidney injury by acute tubular necrosis].

Rev Prat 2018 Feb;68(2):156-159

Unité mixte de recherche UMRS 1155, Inserm, Paris, France.

Acute renal failure by acute tubular necrosis. In adults, acute tubular necrosis is the leading cause of acute kidney injury (AKI). Secondary to ischemia and/or tubular toxicity, the commonly found histological lesions are desquamation of tubular epithelial cells and hyaline intra-tubular deposits. Read More

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February 2018

[Diagnostic procedure for acute kidney failure].

Rev Prat 2018 Feb;68(2):152-156

Service d'urgences néphrologiques et transplantation rénale, service de radiologie, hôpital Tenon, Paris, France.

A diagnostic procedure for acute kidney injury. The definition of acute kidney injury (AKI) is universal since 2011. It is simple, based on the increase in serum creatinine on a short time period. Read More

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February 2018
1 Read

Variation of High-Sensitivity Troponin T Results in Patients Undergoing Continuous Renal Replacement Therapy.

Can J Kidney Health Dis 2019 15;6:2054358119828386. Epub 2019 Feb 15.

Division of Nephrology, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, QC, Canada.

Background: Cardiac troponins are the preferred biomarker to diagnose myocardial injury. Complicating the interpretation of serial troponins in patients with end-stage renal disease, it has been shown that the hemodialysis procedure results in a small but significant decline in high-sensitivity cardiac troponins (hs-cTnT). This raises the possibility that continuous renal replacement therapy (CRRT) might similarly alter cardiac troponin levels and affect their interpretation when cardiac ischemia is being considered. Read More

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http://dx.doi.org/10.1177/2054358119828386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378428PMC
February 2019
2 Reads

Renalase attenuates mitochondrial fission in cisplatin-induced acute kidney injury via modulating sirtuin-3.

Life Sci 2019 Apr 21;222:78-87. Epub 2019 Feb 21.

Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China. Electronic address:

Aims: Acute kidney injury (AKI) can limit the clinical use of cisplatin in cancer treatment. The drivers of cisplatin-induced AKI include oxidative stress, mitochondrial dysfunction and apoptosis. Previous studies showed renalase protected cultured human renal proximal tubular cell (HK-2) against cisplatin induced necrosis, and renalase-knockout mice subjected to cisplatin showed exacerbated kidney injury. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.042DOI Listing
April 2019
2 Reads

Growth arrest and DNA damage 45γ is required for caspase-dependent renal tubular cell apoptosis.

PLoS One 2019 22;14(2):e0212818. Epub 2019 Feb 22.

Department of Nephrology, Ajou University School of Medicine, Suwon, Korea.

Background: Growth Arrest and DNA Damage 45γ (GADD45γ) is a member of the DNA damage-inducible gene family which responds to environmental stresses. Apoptosis is a critical mode of renal tubular cell death in nephrotoxin-induced acute kidney injury. In this study, we investigated the role of GADD45γ in renal tubular cell apoptosis induced by nephrotoxic drugs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212818PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386268PMC
February 2019
2 Reads

Intestinal Toll-like receptor 9 deficiency leads to Paneth cell hyperplasia and exacerbates kidney, intestine, and liver injury after ischemia/reperfusion injury.

Kidney Int 2019 Apr 15;95(4):859-879. Epub 2019 Feb 15.

Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York, USA. Electronic address:

Intestinal Paneth cells play a critical role in ischemic acute kidney injury (AKI) by releasing interleukin 17A (IL-17A). Because Toll-like receptor 9 (TLR9) activation degranulates Paneth cells and necrotic tubular epithelial cells release several damage associated molecular patterns that target TLR9, we tested the hypothesis that intestinal TLR9 deficiency would protect against ischemic AKI and associated remote intestinal and hepatic dysfunction by decreasing Paneth cell degranulation. We generated mice lacking TLR9 in intestinal epithelia (TLR9fl/fl Villin Cre mice) and compared them to wild type (TLR9fl/fl) mice following right nephrectomy and left ischemia/reperfusion. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.035DOI Listing
April 2019
2 Reads

Renal and vascular effects of kallikrein inhibition in a model of Lonomia obliqua venom-induced acute kidney injury.

PLoS Negl Trop Dis 2019 02 14;13(2):e0007197. Epub 2019 Feb 14.

Laboratório de Bioquímica Farmacológica, Centro de Pesquisa Experimental (CPE), Hospital de Clínicas de Porto Alegre (HCPA-UFRGS), Porto Alegre, RS, Brazil.

Background: Lonomia obliqua venom is nephrotoxic and acute kidney injury (AKI) is the main cause of death among envenomed victims. Mechanism underlying L. obliqua-induced AKI involves renal hypoperfusion, inflammation, tubular necrosis and loss of glomerular filtration and tubular reabsorption capacities. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392336PMC
February 2019
4 Reads

Angiopoietin 1 influences ischemic reperfusion renal injury via modulating endothelium survival and regeneration.

Mol Med 2019 02 13;25(1). Epub 2019 Feb 13.

Department of Internal Medicine, National Taiwan University Hospital, No. 7, Jhong-Shan South Road, Taipei, 100, Taiwan.

Background: Damage to the endothelium due to ischemia reperfusion injury (IRI) leads to a disruption of the microvasculature, which could be influenced by angiopoietin 1 via its effects on endothelium. We investigated the physiological and therapeutic roles of angiopoietin 1 in renal IRI using angiopoietin 1 knockout and over-expression mice.

Methods: Renal IRI was induced by clamping the right renal artery seven days after left uninephrectomy for 25 min followed by reperfusion. Read More

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http://dx.doi.org/10.1186/s10020-019-0072-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375134PMC
February 2019
1 Read

Endocan as a marker of microvascular inflammation in kidney transplant recipients.

Sci Rep 2019 Feb 12;9(1):1854. Epub 2019 Feb 12.

Division of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea.

Endocan is a water-soluble proteoglycan exclusively secreted by vascular endothelium. Endocan levels may be elevated in kidney transplant recipients experiencing antibody-mediated rejection (ABMR), which is characterized by vascular inflammation in transplanted kidney. We evaluated the clinical relevance of endocan as markers of microvascular inflammation in patients who underwent kidney transplantation. Read More

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http://dx.doi.org/10.1038/s41598-018-37975-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372712PMC
February 2019
2 Reads

Association of hemophagocytic lymphohistiocytosis with kidney lesions in acute African swine fever virus infection

Ann Parasitol 2018;64(4):343-350

Department of Medical Biology and Parasitology, Armenia Yerevan State Medical University, 2 Koryun St., Yerevan 0025, Armenia

Glomerulonephritis due to African swine fever (ASF) is well documented. However, there is absence of good understanding of mechanisms involved in the development of pathology development. This study examines glomerulonephritis in association with acute infection induced by II genotype (Georgia 2007) of ASF virus. Read More

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April 2019
3 Reads

The aqueous extract of aged black garlic ameliorates colistin-induced acute kidney injury in rats.

Ren Fail 2019 Nov;41(1):24-33

a Department of Internal Medicine , Gyeongsang National University Changwon Hospital , Changwon , Republic of Korea.

The use of colistin in the treatment of multidrug-resistant Gram-negative bacterial infections is restricted due to nephrotoxicity. We investigated the effects of aged black garlic extract (ABGE) on colistin-induced kidney injury in rats. Rats were assigned to four groups. Read More

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http://dx.doi.org/10.1080/0886022X.2018.1561375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366426PMC
November 2019
6 Reads

The spectrum of kidney biopsy findings in patients with morbid obesity.

Kidney Int 2019 Mar 31;95(3):647-654. Epub 2019 Jan 31.

Department of Pathology and Cell Biology, Division of Renal Pathology, Columbia University Medical Center, New York, New York, USA. Electronic address:

Morbid obesity, defined as body mass index (BMI) ≥40 kg/m, affects approximately 8% of United States adults and is a recognized risk factor for chronic kidney disease (CKD). We present the first focused biopsy-based study exploring the range of kidney diseases in this population. Among 3263 native kidney biopsies interpreted at Columbia University in 2017, we identified 248 biopsies from morbidly obese patients. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.026DOI Listing
March 2019
9 Reads

Malaria and acute kidney injury.

Pediatr Nephrol 2019 Jan 31. Epub 2019 Jan 31.

Department of Pediatric Nephrology at The Children's Hospital at Montefiore, 3326 Bainbridge Ave, Bronx, NY, 10029, USA.

Malaria is a parasitic infection transmitted by mosquitos, resulting in significant morbidity and mortality. It affects 212 million worldwide, causing death in up to 303,000 children annually. In the USA, up to 1700 people are affected yearly. Read More

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http://link.springer.com/10.1007/s00467-018-4191-0
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http://dx.doi.org/10.1007/s00467-018-4191-0DOI Listing
January 2019
11 Reads

Human proximal tubular cells can form calcium phosphate deposits in osteogenic culture: role of cell death and osteoblast-like transdifferentiation.

Cell Death Discov 2019 28;5:57. Epub 2019 Jan 28.

1Laboratory of Kidney Histomorphology and Molecular Biology, Clinical Nephrology, Department of Medicine-DIMED, University of Padova, Padova, Italy.

Nephrocalcinosis is a clinicopathological entity characterized by microscopic calcium crystals in the renal parenchyma, within the tubular lumen or in the interstitium. Crystal binding to tubular cells may be the cause underlying nephrocalcinosis and nephrolithiasis. Pathological circumstances, such as acute cortical necrosis, may induce healthy cells to acquire a crystal-binding phenotype. Read More

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http://dx.doi.org/10.1038/s41420-019-0138-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349935PMC
January 2019
6 Reads

The Effect of Overexpression of the Enhancer of Zeste Homolog 1 (EZH1) Gene on Aristolochic Acid-Induced Injury in HK-2 Human Kidney Proximal Tubule Cells In Vitro.

Med Sci Monit 2019 Jan 28;25:801-810. Epub 2019 Jan 28.

Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China (mainland).

BACKGROUND Acute kidney injury (AKI) involves the renal tubular epithelium. The enhancer of zeste homolog 1 (EZH1) gene has a role in cell development and differentiation. This study aimed to investigate the effect of overexpression of the EZH1 gene on aristolochic acid-induced injury in HK-2 human kidney proximal tubule epithelial cells in vitro. Read More

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http://dx.doi.org/10.12659/MSM.911611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362760PMC
January 2019
3 Reads

Acute kidney injury in cirrhosis: implications for liver transplantation.

Curr Opin Crit Care 2019 Apr;25(2):171-178

Department of Critical Care Medicine.

Purpose Of Review: Acute kidney injury (AKI) in cirrhosis consists of varying phenotypes, with hepatorenal syndrome (HRS) representing a single entity. Prompt recognition and diagnosis of AKI cause identifies appropriate therapeutic measures. This review provides an overview of AKI definitions, highlights challenges in quantifying renal impairment in cirrhosis, lists novel diagnostic AKI biomarkers, and summarizes transplantation implications. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000590DOI Listing
April 2019
16 Reads

Hyperbilirubinemia Induces Pro-Apoptotic Effects and Aggravates Renal Ischemia Reperfusion Injury.

Nephron 2019 Jan 23:1-11. Epub 2019 Jan 23.

Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, China,

Aims: Hyperbilirubinemia is associated with postoperative acute kidney injury in patients undergoing cardiac surgeries. A high concentration of bilirubin could induce oxidative stress and cell apoptosis. The aim of this study was to investigate whether hyperbilirubinemia aggravated the renal tubule cells injury and the pro-apoptotic potential of bilirubin on renal ischemia reperfusion injury (RIRI). Read More

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https://www.karger.com/Article/FullText/496066
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http://dx.doi.org/10.1159/000496066DOI Listing
January 2019
8 Reads

[Contrast induced nephropathy : myth or reality ?]

Rev Med Suisse 2019 Jan;15(635):206-210

Service de radiologie diagnostique et interventionnelle, Hôpital de La Tour, Avenue J.-D. Maillard, 1217 Meyrin.

Contrast induced nephropathy has long been considered as the third cause of inpatients acute renal insufficiency after functional renal insufficiency and acute tubular necrosis. This entity is now controversial. Numerous studies failed to show a direct link between intravenous iodinated contrast injection and a worsening of renal function after injected scanners in patients with normal renal function. Read More

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January 2019
7 Reads

S-allyl cysteine protects against lipopolysaccharide-induced acute kidney injury in the C57BL/6 mouse strain: Involvement of oxidative stress and inflammation.

Int Immunopharmacol 2019 Apr 18;69:19-26. Epub 2019 Jan 18.

Neurophysiology Research Center, Department of Physiology, Shahed University, Tehran, Iran. Electronic address:

Sepsis is a serious and life-threatening medical condition with a higher rate of patients' morbidity and mortality and with complications such as acute kidney injury (AKI). S-allyl cysteine (SAC) is the active constituent of the medicinal plant garlic (Allium sativum) with multiple beneficial effects including anti-inflammatory and antioxidant properties. In this research, we tried to determine the protective effect of SAC pretreatment in a mouse model of AKI. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.026DOI Listing
April 2019
4 Reads
2.472 Impact Factor