6,770 results match your criteria Acute Tubular Necrosis


Clinical and pathological characteristics of patients with acute kidney injury in Japan in whom kidney biopsy was performed: a cross-sectional analysis of the Japan Renal Biopsy Registry (J‑RBR).

Clin Exp Nephrol 2022 May 20. Epub 2022 May 20.

Department of Pathology, Keio University School of Medicine, Tokyo, Japan.

Introduction: Acute kidney injury (AKI) is a worldwide concern and it leads to a poor prognosis or end-stage kidney disease. The purpose of this study was to clarify the characteristics of patients with AKI in whom kidney biopsy was performed using data of the Japan Renal Biopsy Registry (J-RBR).

Methods: We screened 38,351 cases that were registered in the J-RBR from 2007 to 2018. Read More

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Acute Aluminum Sulfate Triggers Inflammation and Oxidative Stress, Inducing Tissue Damage in the Kidney of the Chick.

Biol Trace Elem Res 2022 May 13. Epub 2022 May 13.

College of Life Science and Engineering, Foshan University, Foshan, Guangdong, 528231, People's Republic of China.

In this study, a total of 20 7-day-old chicks were randomly divided into an experimental group and a control group. The experimental group was administered aluminum sulfate (Al(SO)) once by gavage, and the control group was sacrificed after 24 h of fasting with distilled water. Serum and kidney tissue samples from both groups were collected and compared using hematoxylin-eosin staining (H&E) and microscopy. Read More

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The α7nAChR agonist PNU-282987 ameliorates sepsis-induced acute kidney injury via CD4+CD25+ regulatory T cells in rats.

Bosn J Basic Med Sci 2022 May 10. Epub 2022 May 10.

Department of Surgical Intensive Critical Unit, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.

The ameliorative effects of α7 nicotinic acetylcholine receptor (α7nAChR) agonists have been demonstrated in acute kidney injury (AKI) caused by multiple stimulations. However, the ameliorative effect of α7nAChR on sepsis-induced acute kidney injury (SAKI) in the cecal ligation and puncture (CLP) model is unclear. Previous studies have demonstrated that α7nAChR is highly expressed on the surface of CD4+CD25+ regulatory T cells (Tregs). Read More

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Incidental Pathogenic Fibrin-Associated Diffuse Large B-cell Lymphoma Found During Aorto-Biiliac Bypass.

Cureus 2022 Mar 31;14(3):e23681. Epub 2022 Mar 31.

Department of Surgery, Beaumont Health, Farmington Hills, USA.

Fibrin-associated diffuse large B-cell lymphoma (FA-DLBCL) is in and of itself a rare entity and is a subset of the Epstein-Barr virus (EBV)-associated lymphoma. Due to its indolent course, FA-DLBCL is generally an incidental finding on histopathological examinations. We present the first reported case of FA-DLBCL found within a native aortic thrombus during an aorto-biiliac bypass. Read More

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A Case of Childhood Severe Paroxysmal Cold Hemoglobinuria with Acute Renal Failure Successfully Treated with Plasma Exchange and Eculizumab.

Case Rep Pediatr 2022 22;2022:3267189. Epub 2022 Apr 22.

Carilion Children's Pediatric Hematology/Oncology, Carilion Clinic, Roanoke, VA, USA.

We describe the case of a 4-year-old female who presented with sepsis and disseminated intravascular coagulation (DIC), developed ongoing intravascular hemolysis with acute renal failure from suspected pigment-induced acute tubular necrosis necessitating continuous renal replacement therapy (CRRT) for five days followed by four episodes of intermittent hemodialysis (iHD), and was subsequently diagnosed with paroxysmal cold hemoglobinuria (PCH). She was successfully treated with plasma exchange and eculizumab, a humanized monoclonal antibody targeting complement protein C5, and demonstrated significant improvement of hemolysis and recovery of renal function. Read More

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A rare case of cade oil poisoning complicated by acute pancreatitis and acute tubular necrosis.

Ann Med Surg (Lond) 2022 Apr 4;76:103562. Epub 2022 Apr 4.

Anesthesia, Intensive Care and Resuscitation Department, MOHAMMED VI University Hospital Center, Oujda, Morocco.

Introduction: Cade oil is often used in traditional medicinal practices despite of its toxic effects, hence the occurrence of intoxication incidents often requiring intensive care.

Case Presentation: We present the case of a young patient with no prior medical history who was exposed to significant doses of Cade oil both on skin and ingested, and who subsequently developed an apyretic consciousness disorder warranting an admission to our ICU department for specialized management.

Discussion: in this chapter we discuss the place of cade oil within Morocco's unsupervised medicinal practices. Read More

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Rhabdomyolysis, myoglobinuric nephrosis, and crystalline nephropathy in a captive bottlenose dolphin.

J Vet Diagn Invest 2022 Apr 27:10406387221090516. Epub 2022 Apr 27.

Departments of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.

A 5-y-old female bottlenose dolphin () from an aquarium in Japan had clinical signs of anorexia, vomiting, and bradykinesia. Enrofloxacin and lactated Ringer solution were administered for treatment of bacterial infection and for rehydration. Elevations of creatine kinase and aspartate aminotransferase activities were detected on day 4 of treatment, indicating that rhabdomyolysis had developed on day 3. Read More

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TLR2/caspase-5/Panx1 pathway mediates necrosis-induced NLRP3 inflammasome activation in macrophages during acute kidney injury.

Cell Death Discov 2022 Apr 26;8(1):232. Epub 2022 Apr 26.

Clinical Research Center of Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China.

Acute kidney injury (AKI) is characterized by necroinflammation formed by necrotic tubular epithelial cells (TECs) and interstitial inflammation. In necroinflammation, macrophages are key inflammatory cells and can be activated and polarized into proinflammatory macrophages. Membranous Toll-like receptors (TLRs) can cooperate with intracellular NOD-like receptor protein 3 (NLRP3) to recognize danger signals from necrotic TECs and activate proinflammatory macrophages by assembling NLRP3 inflammasome. Read More

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The Nephroprotective Effects of α-Bisabolol in Cisplatin-Induced Acute Kidney Injury in Mice.

Biomedicines 2022 Apr 3;10(4). Epub 2022 Apr 3.

Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates.

Cisplatin (CP) treatment has been long associated with the development of acute kidney injury (AKI) through mechanisms involving inflammation and oxidative stress. α-Bisabolol (BIS), a sesquiterpene alcohol isolated from the essential oil of various plants, including chamomile, has garnered popularity lately due to its antioxidant, anti-inflammatory, and anticancer properties. Therefore, we investigated the nephroprotective effects of BIS in the murine model of CP-induced AKI and the underlying mechanism of action. Read More

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Protocol-based donor-derived cell-free DNA surveillance in kidney transplant recipients: A single-center experience.

Clin Nephrol 2022 Apr 21. Epub 2022 Apr 21.

Aims: Donor-derived cell-free DNA (dd-cfDNA) surveillance testing has never been studied in comparison with other surveillance tests. In this study we aim to describe our center's clinical experience with routine dd-cfDNA monitoring and to assess whether monitoring dd-cfDNA by protocol provides additional information that aids in detection of acute rejection.

Materials And Methods: We implemented the dd-cfDNA (Allosure) surveillance protocol in addition to measurements of serum creatinine, proteinuria, and donor-Specific antibody. Read More

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COVID-19 and Acute Kidney Injury: A Systematic Review.

Front Med (Lausanne) 2022 4;9:705908. Epub 2022 Apr 4.

Division of Pulmonary and Critical Care, College of Medicine-Jacksonville, University of Florida, Jacksonville, FL, United States.

Introduction: Acute kidney injury (AKI) has been associated with an increased mortality rate among hospitalized patients with Coronavirus disease 2019 (COVID-19). The current review aimed to evaluate the symptoms, complications, and treatments performed to manage AKI in patients with COVID-19.

Methods: We searched PubMed/Medline, Web of Science, and Embase for the relevant scientific literature published up to February 1, 2022. Read More

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A rat model of acute kidney injury caused by multiple subcutaneous injections of Asian giant hornet (Vespa mandarina Smith) venom.

Toxicon 2022 Jul 15;213:23-26. Epub 2022 Apr 15.

Department of Nephrology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441000, China. Electronic address:

A model of acute kidney injury (AKI) caused by multiple subcutaneous injections of Asian giant hornet (Vespa mandarina Smith) venom was developed in male Wistar rats. The rats were injected subcutaneously at multiple sites in the dorsal region with a total venom dose of 5 mg/kg. Blood samples were obtained 8, 24 and 48 h after venom injection for the quantification of various biochemical parameters and assessment of renal function. Read More

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Protective effect of d-alanine against acute kidney injury.

Am J Physiol Renal Physiol 2022 Jun 18;322(6):F667-F679. Epub 2022 Apr 18.

Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.

Recent studies have revealed the connection between amino acid chirality and diseases. We have previously reported that the gut microbiota produces various d-amino acids in a murine acute kidney injury (AKI) model. Here, we further explored the pathophysiological role of d-alanine (d-Ala) in AKI. Read More

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Inhibition of attenuates renal injury and inflammation by alleviating m6A modifications via IGF2BP2-dependent mechanisms.

Sci Transl Med 2022 Apr 13;14(640):eabk2709. Epub 2022 Apr 13.

Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the Key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, China.

The role of -methyladenosine (m6A) modifications in renal diseases is largely unknown. Here, we characterized the role of -adenosine-methyltransferase-like 3 (METTL3), whose expression is elevated in renal tubules in different acute kidney injury (AKI) models as well as in human biopsies and cultured tubular epithelial cells (TECs). silencing alleviated renal inflammation and programmed cell death in TECs in response to stimulation by tumor necrosis factor-α (TNF-α), cisplatin, and lipopolysaccharide (LPS), whereas overexpression had the opposite effects. Read More

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Shikonin attenuates kidney tubular epithelial cells apoptosis, oxidative stress, and inflammatory response through nicotinamide adenine dinucleotide phosphate oxidase 4/PTEN pathway in acute kidney injury of sepsis model.

Drug Dev Res 2022 Apr 13. Epub 2022 Apr 13.

Department of Critical Care Medicine, Second Hospital of Shanxi Medical University, Taiyuan, China.

Natural compounds were used in the treatment of acute kidney injury (AKI) caused by sepsis. This study investigated the function of shikonin from the roots of Arnebia purpurea in sepsis-induced AKI model. The target genes of shikonin were predicted by traditional Chinese medicine integrative database (TCMID). Read More

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HSP70 Ameliorates Septic Acute Kidney Injury via Binding with TRAF6 to Inhibit of Inflammation-Mediated Apoptosis.

J Inflamm Res 2022 5;15:2213-2228. Epub 2022 Apr 5.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Purpose: Acute kidney injury (AKI) is one of the most severe complications of sepsis, the pathological features of which are excessive inflammation and programmed cell death of resident renal cells. Heat shock protein 70 (HSP70) is a critical stress protein for repressing inflammation, however, its role in AKI is not fully understood. The current study aimed to determine the protective effect of HSP70 on septic AKI and its underlying mechanisms. Read More

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The Urinary Level of Injury Biomarkers Is Not Univocally Reflective of the Extent of Toxic Renal Tubular Injury in Rats.

Int J Mol Sci 2022 Mar 23;23(7). Epub 2022 Mar 23.

Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.

Nephrotoxicity is a major cause of intrinsic acute kidney injury (AKI). Because renal tissue damage may occur independently of a reduction in glomerular filtration rate and of elevations in plasma creatinine concentration, so-called injury biomarkers have been proposed to form part of diagnostic criteria as reflective of tubular damage independently of renal function status. We studied whether the urinary level of NGAL, KIM-1, GM2AP, t-gelsolin, and REGIIIb informed on the extent of tubular damage in rat models of nephrotoxicity, regardless of the etiology, moment of observation, and underlying pathophysiology. Read More

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Acute Kidney Injury in Critically-Ill COVID-19 Patients.

J Clin Med 2022 Apr 5;11(7). Epub 2022 Apr 5.

Service de Médecine Intensive Réanimation, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Henri Mondor, 94010 Creteil, France.

Purpose: Acute kidney injury (AKI) is common in patients with COVID-19, however, its mechanism is still controversial, particularly in ICU settings. Urinary proteinuria profile could be a non-invasive tool of interest to scrutinize the pathophysiological process underlying AKI in COVID-19 patients.

Material And Methods: We conducted a retrospective study between March 2020 and April 2020. Read More

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Pentoxifylline mitigates cholestasis-related cholemic nephropathy.

Clin Exp Hepatol 2021 Dec 25;7(4):377-389. Epub 2021 Nov 25.

Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Aim Of The Study: Cholestasis is the stoppage of bile flow that primarily affects liver function. On the other hand, kidneys are also severely influenced during cholestasis. Cholestasis-induced kidney injury is known as cholemic nephropathy (CN). Read More

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December 2021

Bunge (Danshen) and Bioactive Compound Tanshinone IIA Alleviates Cisplatin-Induced Acute Kidney Injury Through Regulating PXR/NF-κB Signaling.

Front Pharmacol 2022 24;13:860383. Epub 2022 Mar 24.

Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

The present study aims to provide evidence on the potential protective role of Bunge (Danshen) and its bioactive compound Tanshinone IIA (TanIIA) in AKI and to reveal the specific regulatory function of PXR/NF-κB signaling in AKI-induced renal inflammation. A network pharmacological analysis was used to study target genes and regulatory networks in the treatment of on AKI. Further experiments with AKI mouse model and studies were applied to investigate the renal protective effect of TanIIA in AKI. Read More

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Delayed Graft Function Under the Microscope: Surveillance Biopsies in Kidney Transplantation.

Transpl Int 2022 24;35:10344. Epub 2022 Mar 24.

Division of Nephrology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.

Delayed graft function (DGF) is a common complication of kidney transplantation and frequently leads to the necessity of surveillance biopsies. The purpose of this study is to describe the histological findings in surveillance biopsies of deceased donor kidney transplant recipients and evaluate the risk factors for graft outcomes. This is a monocentric, retrospective study including kidney transplant recipients that underwent a graft biopsy during the DGF period between January 2006 and July 2019. Read More

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Reversible Ischemic Nephropathy in a Deceased Donor Renal Transplant Recipient With BK Nephropathy.

Exp Clin Transplant 2022 Mar;20(Suppl 1):132-135

From the Nephrology Department, Hamed Al-Essa Organ Transplant Center, Sabah Area, Kuwait.

Atherosclerotic renal artery stenosis is one of the risk factors for cardiovascular death and can lead to the ischemic nephropathy. In this report, we describe the successful management of ischemic nephropathy that developed in a kidney transplant recipient with graft artery stenosis. The 52-year-old male patient had diabetes and hypertension and was a nonsmoker with hypothyroidism on replacement therapy. Read More

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Protective and Curative Effects of Ethanol extract of Tinospora Cordifolia on Gentamicin-induced Nephrotoxicity in Rats.

Mymensingh Med J 2022 Apr;31(2):437-442

Dr Nasrin Akter Maya, Assistant Professor, Department of Pharmacology and Therapeutics, CARe Medical College, Dhaka, Bangladesh; E-mail:

Gentamicin induced acute tubular necrosis (ATN) in intrinsic variety of acute renal failure (ARF) results from oxidative stress leading to cellular lipid peroxidation. Tinospora cordifolia (Tc), locally named as 'Guluncha' is an herbal plant with medicinal value possess antioxidant property as well as significant scavenging activity in different extracts and easily available in Bangladesh. This prospective study was approved by the Institutional Review Board of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Read More

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Renal Recovery and Mortality Risk among Patients with Hepatorenal Syndrome Receiving Chronic Maintenance Dialysis.

Kidney360 2021 May 3;2(5):819-827. Epub 2021 Mar 3.

Division of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, California.

Background: Kidney replacement therapy is controversial for patients with hepatorenal syndrome who may not be liver transplant candidates. Data surrounding the likelihood of recovery of kidney function and mortality after outpatient dialysis initiation in patients with dialysis-requiring hepatorenal syndrome could inform discussions between patients and providers.

Methods: We performed a retrospective cohort study of patients with hepatorenal syndrome who were registered in the United States Renal Data System between 1996 and 2015 (=7830) as receiving maintenance dialysis. Read More

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Stem Cell-Derived Extracellular Vesicles as Potential Therapeutic Approach for Acute Kidney Injury.

Front Immunol 2022 10;13:849891. Epub 2022 Mar 10.

Nephrology and Kidney Transplantation Unit, "Maggiore della Carità" University Hospital, Department of Translational Medicine, Translational Research on Autoimmune and Allergic Disease (CAAD), University of Piemonte Orientale (UPO), Novara, Italy.

Acute kidney injury is a frequent complication of hospitalized patients and significantly increases morbidity and mortality, worsening costs and length of hospital stay. Despite this impact on healthcare system, treatment still remains only supportive (dialysis). Stem cell-derived extracellular vesicles are a promising option as they recapitulate stem cells properties, overcoming safety issues related to risks or rejection or aberrant differentiation. Read More

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The Challenges of Diagnosing Nondilated Obstructive Uropathy: A Case Report.

Can J Kidney Health Dis 2022 26;9:20543581221086683. Epub 2022 Mar 26.

Division of Nephrology, Rush University Medical Center, Chicago, IL, USA.

Rationale: Nondilated obstructive uropathy (NDOU) is a rare cause of acute renal failure reported in less than 5% of cases of obstructive uropathy. It is typically associated with intrapelvic malignancies and diseases causing retroperitoneal lymphadenopathy and retroperitoneal fibrosis. As these conditions may prevent radiographic dilation of the collecting system, the diagnosis of NDOU may be missed by usual diagnostic testing. Read More

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A "cat"-astrophic case of Bartonella infective endocarditis causing secondary cryoglobulinemia: a case report.

BMC Rheumatol 2022 Mar 25;6(1):16. Epub 2022 Mar 25.

The Kellgren Centre of Rheumatology, Manchester Royal Infirmary, Oxford Road, Manchester, UK.

Background: Culture-negative infective endocarditis (IE) constitutes approximately 10% of all cases of IE. Bartonella endocarditis is a common cause of culture-negative endocarditis and is associated with a high mortality rate. To date, no cases of Bartonella IE has been reported in association with cryoglobulinemia in the UK. Read More

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Ethylene glycol toxicosis in milk-fed dairy calves.

Acta Vet Scand 2022 Mar 24;64(1). Epub 2022 Mar 24.

Department of Veterinary Clinical Sciences, University of Copenhagen, 1870, Frederiksberg C, Denmark.

Background: Ethylene glycol (EG) (antifreeze) toxicosis has mostly been reported in dogs and cats, while reports on EG toxicosis in cattle are sparse. We report EG toxicosis in 25 milk-fed calves associated with a leak in the cooling pipes in a milk taxi. The milk taxi was connected to a geothermal heating system in which EG was used as antifreeze. Read More

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Toxicity of commercial atrazine in rattus novergicus organs as a function of concentration: histopathological, ultrastructural and hematological evaluation.

An Acad Bras Cienc 2022 18;94(2):e20201125. Epub 2022 Mar 18.

Universidad Especializada de las Américas, Faculty of Biosciences and Public Health, Paseo de la Iguana, 00629 Panamá, Panamá.

The effect of commercial Atrazine (ATR) on Rattus Novergicus organs was determined for a concentration of cATR of 1, 3, 13, 30, and 50 ppb. ATR was dissolved in drinking water. The rats were allowed to drink from it ad libitum for an uninterrupted period of 28 days as established by the Office of Environmental Protection protocol under the number EPA OPPTS 870. Read More

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Blockade of STAT3 signaling alleviates the progression of acute kidney injury to chronic kidney disease through antiapoptosis.

Am J Physiol Renal Physiol 2022 May 21;322(5):F553-F572. Epub 2022 Mar 21.

Kidney Research Institute, Seoul National University, Seoul, Korea.

Signal transducer and activator of transcription 3 (STAT3) is a pivotal mediator of IL-6-type cytokine signaling. However, the roles of its full-length and truncated isoforms in acute kidney injury (AKI) and its transition to chronic kidney disease (CKD) remain elusive. Herein, the role of STAT3 isoforms in the AKI-to-CKD transition was characterized using an ischemia-reperfusion injury (IRI) mouse model. Read More

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