6,568 results match your criteria Acute Tubular Necrosis


The impact of Caspase-1 deletion on apoptosis and acute kidney injury in a murine transplant model.

Cell Signal 2021 May 12:110039. Epub 2021 May 12.

University of Colorado Anschutz Medical Center, 12700 E. 19th Ave, Aurora, CO 80045, United States of America; Rocky Mountain Regional VA Medical Center, 1700 N Wheeling St, Aurora, CO 80045, United States of America. Electronic address:

Background: Caspase-1 knockout mice (Casp1KO) are protected from Acute Kidney Injury (AKI) after warm ischemia/reperfusion injury in non-transplant models. Since Caspase-1 plays a central role as an inflammatory response initiator, we hypothesized that Casp1KO mice would be protected from AKI following transplant.

Methods: Renal tubular cells (RTECs) were subjected to cold storage and rewarming (CS/REW). Read More

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First report of fatal baylisascariasis-induced acute pancreatitis in a giant panda.

Parasitol Int 2021 May 10:102380. Epub 2021 May 10.

Sichuan Key Laboratory of Conservation Biology for Endangered Wildlife, Chengdu Research Base of Giant Panda Breeding, Sich3uan Academy of Giant Panda, Chengdu, Sichuan, China.

A wild adult male giant panda that was rescued from a nature reserve in Sichuan Province, China, has died. The panda had been in poor physical condition: it was wheezing and had increased serum amylase. A pathological examination was performed in order to determine the cause of death. Read More

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Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study.

Clin Transl Gastroenterol 2021 May 11;12(5):e00359. Epub 2021 May 11.

Liver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Introduction: Urinary neutrophil gelatinase-associated lipocalin (NGAL) has shown promise in differentiating acute tubular necrosis (ATN) from other types of acute kidney injuries (AKIs) in cirrhosis, particularly hepatorenal syndrome (HRS). However, NGAL is not currently available in clinical practice in North America.

Methods: Urinary NGAL was measured in a prospective cohort of 213 US hospitalized patients with decompensated cirrhosis (161 with AKI and 52 reference patients without AKI). Read More

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Case Report: Acute Kidney Failure due to Massive Envenomation of a Two-Year-Old Child Caused by Killer Bee Stings.

Am J Trop Med Hyg 2021 May 10. Epub 2021 May 10.

1Service de Médecine et Chirurgie Pédiatrique, Cayenne Hospital, Cayenne, French Guiana.

A hybrid species of Brazilian bee has proliferated on the South American continent since 1956. We describe a "killer bee" swarm attack on a 2-year-old girl in French Guiana. The patient weighed 10 kg, and approximately hundreds of bees' stingers were removed, that is, 10 stings/kg. Read More

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Induction of renal tumor necrosis factor-alpha and other autacoids and the beneficial effects of hypertonic saline in acute decompensated heart failure.

Am J Physiol Renal Physiol 2021 May 10. Epub 2021 May 10.

Department of Pharmacology, New York Medical College, United Statesgrid.260917.b.

While administration of Hypertonic Saline (HSS) in combination with diuretics has yielded improved weight loss, preservation of renal function, and reduction in hospitalization time in the clinical setting of patients with acute decompensated heart failure (ADHF), the mechanisms that underlie these beneficial effects remain unclear and additional studies are needed before this approach can be adopted on a more consistent basis. As high salt conditions stimulate production of several renal autacoids that exhibit natriuretic effects, renal physiologists can contribute to the understanding of mechanisms by which HSS leads to increased diuresis both as an individual therapy, as well as in combination with loop diuretics. For instance, since HSS increases TNF-α production by proximal tubule (PT) and thick ascending limb of Henle's loop (TAL) epithelial cells, this 'Perspective article' is aimed at highlighting how the effects of TNF-α produced by these cell types may contribute to the beneficial effects of HSS in patients with ADHF. Read More

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MiR-182 Promotes Ischemia/Reperfusion-Induced Acute Kidney Injury in Rat by Targeting FoxO3.

Urol Int 2021 May 7:1-10. Epub 2021 May 7.

Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.

Background: Renal ischemia/reperfusion (I/R) injury (RIRI) is the main cause of acute kidney injury (AKI) in patients. We investigated the role of miR-182 after renal ischemia/reperfusion (I/R) in rat to characterize the microRNA (miRNA) network activated during development and recovery from RIRI.

Methods And Results: 12 h after lethal (45 min) renal ischemia, AKI was verified by renal histology (tubular necrosis and regeneration), blood urea nitrogen level, and renal mRNA expression in Wistar rats. Read More

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Postmortem pathological changes in extrapulmonary organs in SARS-CoV-2 rt-PCR-positive cases: a single-center experience.

Ir J Med Sci 2021 May 7. Epub 2021 May 7.

Council of Forensic Medicine, Istanbul, Turkey.

Background: Although the lung is seen as the main target organ affected by SARS-CoV-2, other organs are also damaged.

Aim: We aimed to determine the extrapulmonary findings of autopsies performed on cases with positive results with postmortem polymerase chain reaction test.

Methods: Pathological changes in extrapulmonary organs were examined with light microscopy. Read More

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Pathology of Lagovirus europaeus GI.2/RHDV2/b (Rabbit Hemorrhagic Disease Virus 2) in Native North American Lagomorphs.

J Wildl Dis 2021 May 7. Epub 2021 May 7.

US Geological Survey National Wildlife Health Center, 6006 Schroeder Rd., Madison, Wisconsin 53711, USA.

Rabbit hemorrhagic disease, a notifiable foreign animal disease in the US, was reported for the first time in wild native North American lagomorphs in April 2020 in the southwestern US. Affected species included the desert cottontail (Sylvilagus audubonii), mountain cottontail (Sylvilagus nuttallii), black-tailed jackrabbit (Lepus californicus), and antelope jackrabbit (Lepus alleni). Desert cottontails (n=7) and black-tailed jackrabbits (n=7) collected in April and May 2020 were necropsied at the US Geological Survey National Wildlife Health Center and tested positive for Lagovirus europaeus GI. Read More

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Incomplete Recovery from COVID-19 associated Acute Kidney Injury (AKI) in Kidney Transplant Recipients: Prior Graft Injury Matters The Most.

Authors:
Umberto Maggiore

Transpl Int 2021 May 7. Epub 2021 May 7.

Dipartimento di Medicina e Chirurgia, Università di Parma, UO Nefrologia, Azienda Ospedaliera-Universitaria Parma, Parma, Italy.

Acute kidney injury (AKI) occurs frequently in the course of COVID-19 in the general population, its incidence ranging from 7% in hospitalized patients to above 20% in patients admitted to ICU. The definitive pathogenesis is still unclear. However, because in most cases the pattern of injury is acute tubular necrosis and endothelial injury, it is likely that most cases of AKI are the result of hemodynamic instability, cytokine-related injury, and dysfunction of the coagulation cascade. Read More

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Recent use of formaldehyde-'free' hair straightening product and severe acute kidney injury.

Clin Kidney J 2021 May 11;14(5):1469-1471. Epub 2021 Jan 11.

Edith Wolfson Medical Center Ringgold Standard Institution, Holon, Israel.

Formaldehyde is present in hair straightening products even when labeled as formaldehyde-free. Inhaled absorption of formaldehyde causes renal tubular cytotoxicity. We report a teenager who developed severe acute kidney injury requiring renal replacement therapy shortly after exposure to a formaldehyde-'free' hair straightening product. Read More

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Yellow Fever as Cause of Death of Titi Monkeys ( Spp.).

Vet Pathol 2021 May 6:3009858211009781. Epub 2021 May 6.

Universidade de São Paulo, São Paulo, Brazil.

From 2016 to 2018, an epidemic wave of yellow fever (YF) occurred in Brazil, affecting a large number of Platyrrhini monkeys. Titi monkeys ( spp.) were severely affected yet pathological characterizations are lacking. Read More

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Ultrasound enhances the therapeutic potential of mesenchymal stem cells wrapped in greater omentum for aristolochic acid nephropathy.

Stem Cell Res Ther 2021 May 3;12(1):261. Epub 2021 May 3.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing, 100853, China.

Background: Mesenchymal stem cells (MSCs) have been reported to promote regeneration in both subjects with acute kidney injury (AKI) and chronic kidney disease (CKD), but their efficacy remains limited, probably because most of the cells accumulate in the lungs, liver, and spleen after an intravenous infusion. Therefore, ultrasound-guided administration of MSCs represents a possible approach to solve this problem. The greater omentum is used to promote cell survival due to its rich vasculature. Read More

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Alternating and Concurrent True Hyperkalemia and Pseudohyperkalemia in Adult Sickle Cell Disease.

Rambam Maimonides Med J 2021 Apr 29;12(2). Epub 2021 Apr 29.

The Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, Vermont, USA.

Sickle cell disease (SCD) predisposes the patient to recurrent episodes of acute painful hemolytic crisis. Sickle cell nephropathy (SCN) is not uncommon in adult patients, and renal manifestations of SCN include renal ischemia, microinfarcts, renal papillary necrosis, and renal tubular abnormalities with variable clinical presentations. Intravascular hemolysis and reduced glomerular filtration rate with renal tubular dysfunction predispose to true hyperkalemia. Read More

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Vitamin C-Induced Oxalate Nephropathy in a Septic Patient.

Crit Care Explor 2021 Apr 26;3(4):e0389. Epub 2021 Apr 26.

Department of Medicine, Division of Critical Care Medicine, Maisonneuve-Rosemont Hospital, Affiliated With University of Montreal, Montreal, QC, Canada.

Vitamin C is a novel treatment currently under investigation in the management of sepsis. Adverse renal effects of vitamin C through hyperoxaluria have been described in the past.

Data Sources: We report the case of a 63-year-old man admitted in a community-based hospital with a diagnosis of sepsis of pulmonary origin. Read More

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COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system.

Nat Commun 2021 04 23;12(1):2417. Epub 2021 Apr 23.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

SARS-CoV-2 uses ACE2, an inhibitor of the Renin-Angiotensin-Aldosterone System (RAAS), for cellular entry. Studies indicate that RAAS imbalance worsens the prognosis in COVID-19. We present a consecutive retrospective COVID-19 cohort with findings of frequent pulmonary thromboembolism (17%), high pulmonary artery pressure (60%) and lung MRI perfusion disturbances. Read More

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Recombinant apoptosis inhibitor of macrophage protein reduces delayed graft function in a murine model of kidney transplantation.

PLoS One 2021 23;16(4):e0249838. Epub 2021 Apr 23.

Department of Microbiology and Immunology, Western University, London, Ontario, Canada.

Reperfusion injury following cold and warm ischemia (IRI) is unavoidable during kidney transplantation and contributes to delayed graft function (DGF) and premature graft loss. Death of tubular epithelial cells (TECs) by necrosis during IRI releases pro-inflammatory mediators (e.g. Read More

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Secretory Leukocyte Proteinase Inhibitor Protects Acute Kidney Injury Through Immune and Non-Immune Pathways.

Shock 2021 Apr 20. Epub 2021 Apr 20.

Universidad de Buenos Aires, Consejo Nacional de lnvestigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos (CEFYBO). Facultad de Medicina. Buenos Aires, Argentina Facultad de Ingeniería y Ciencias Agrarias, BIOMED UCA-CONICET, Argentina Instituto de Trasplante y Alta Complejidad (ITAC), Nefrología de Buenos Aires, Buenos Aires, Argentina Fundación GADOR, Argentina Universidad de Buenos Aires, Facultad de Medicina, Departamento de Microbiología, Parasitología e Inmunología, Buenos Aires, Argentina.

Abstract: Acute kidney injury (AKI) is characterized by rapid loss of excretory function and is the clinical manifestation of several disorders affecting the kidney. The aim of the present study was to investigate the mechanism of action of Secretory Leukocyte Proteinase Inhibitor (SLPI) that protects the kidneys form AKI. In vivo and in vitro experiments were performed to assess the effect of SLPI on kidney injury. Read More

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The Role of Renal Pathology in the Prognosis and Recovery of Community-Acquired Acute Kidney Injury.

Nephron 2021 Apr 21:1-10. Epub 2021 Apr 21.

Division of Nephrology, Kidney Institute of CPLA, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Objectives: The determinants leading to different renal outcomes in community-acquired acute kidney injury (CA-AKI) and the influence of renal histological damage on the prognosis and recovery of CA-AKI are scarcely reported.

Methods: Adult patients with CA-AKI admitted to Shanghai Changzheng Hospital with renal biopsy profiles from January 1, 2010, to December 31, 2018, were enrolled in our cohort. After 3 months of follow-up, clinical outcomes, including patient survival, dialysis requirement during hospitalization and at 3 months, CKD stage 3-5, and renal functional recovery at 3 months, were analyzed, and risk factors were identified. Read More

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Concomitant Acute Tubular Necrosis and Acute Interstitial Nephritis Induced by Tipifarnib in a Patient with Squamous Cell Carcinoma of the Lung.

Am J Med Sci 2021 Apr 16. Epub 2021 Apr 16.

Nephrology Department, Hospital Universitario Fundación Alcorcón, Madrid, Spain.

Tipifarnib is a novel targeted treatment for hematologic malignancies that is being recently studied for the treatment of advanced solid organ tumors with HRAS mutations. There have been scarce reports on kidney adverse events in initial phase I and II trials. We present a case of acute kidney injury in a patient that had started treatment with tipifarnib for advanced squamous cell carcinoma of the lung. Read More

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Reconstruction of COVID-19-Related Compartment Syndrome With Massive Soft Tissue Necrosis.

Wounds 2021 Apr;33(4):99-105

Rubin Institute for Advanced Orthopedics, Baltimore, Maryland.

Introduction: The COVID-19 virus is caused by the new coronavirus, SARS-CoV-2. COVID-19 has drastically changed the medical landscape. Although predominantly impacting the respiratory system, COVID-19 has several non-respiratory symptoms associated with its presentation and course. Read More

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Renal hemosiderosis presenting with acute kidney Injury and macroscopic hematuria in Immunoglobulin A nephropathy: a case report.

BMC Nephrol 2021 Apr 15;22(1):132. Epub 2021 Apr 15.

Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, 1370-1 Okamoto, 247-8553, Kamakura, Kanagawa, Japan.

Background: Macroscopic hematuria-associated acute kidney injury (AKI) is a well-known complication of immunoglobulin A (IgA) nephropathy. In such cases, intratubular obstruction by red blood cell (RBC) casts and acute tubular necrosis are mainly observed pathologically. Herein, we report the case of a patient with IgA nephropathy presenting with AKI following an episode of macrohematuria. Read More

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Kidney Injury in Multiple Myeloma: A Kidney Biopsy Teaching Case.

Kidney Med 2021 Mar-Apr;3(2):303-306. Epub 2021 Feb 5.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.

Myeloma-related kidney disease has several manifestations; the 2 most common histologic diagnoses are myeloma cast nephropathy and acute tubular necrosis. We describe a case of different kidney pathologies occurring concomitantly in a patient found to have immunoglobulin A κ multiple myeloma. A White woman in her 70s presented with an 8-month history of back pain and was found to have nephrotic-range proteinuria and acute kidney injury. Read More

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February 2021

Reconstruction of post-osteomyelitis 1 ray phalangeal loss by reverse dermis cross toe flap and fibula bone grafting: A rare case report.

Foot (Edinb) 2021 Feb 4:101782. Epub 2021 Feb 4.

OrthoKids Clinic, Ahmedabad, Gujarat, India. Electronic address:

Osteomyelitis is defined as infection of the bone and its marrow. It is more common in children due to growing bones and rich blood supply. Although long tubular bones are most common to get involved, no bone is exempted from acute hematogenous osteomyelitis and metatarsals account for 2% of all cases of acute hematogenous osteomyelitis. Read More

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February 2021

Utility of Urinary Neutrophil Gelatinase Associated Lipocalin (NGAL) in Decompensated Cirrhosis.

Indian J Nephrol 2020 Nov-Dec;30(6):391-397. Epub 2019 Nov 11.

Department of Biochemistry, JIPMER, Pondicherry, India.

Background And Aims: Renal failure occurring in the setting of cirrhosis increases mortality by more than threefold. Serum creatinine, the conventional marker for renal dysfunction has inherent limitations in identifying and categorizing renal dysfunction in patients with chronic liver disease (CLD). Neutrophil gelatinase associated lipocalin (NGAL) is a novel biomarker which gets upregulated as early as 2-6 hours following the insult to renal tubules. Read More

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November 2019

Hydrogen sulfide reduces pyroptosis and alleviates ischemia-reperfusion acute kidney injury by inhibiting NLRP3 inflammasome.

Life Sci 2021 Mar 31:119466. Epub 2021 Mar 31.

Department of Critical Care Medicine, Minhang Hospital, Fudan University, Shanghai 201199, China. Electronic address:

Aims: Ischemia-reperfusion (I/R)-induced acute kidney injury (AKI) shows high mortality. Hydrogen sulfide (HS) is essential for regulating kidney function. This study explored the role and mechanism of HS in I/R-induced AKI. Read More

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Valproate attenuates hypertonic glycerol-induced rhabdomyolysis and acute kidney injury.

Nephrol Ther 2021 Mar 26. Epub 2021 Mar 26.

Department of pharmacology, Faculty of medicine, Assiut University, 71515 Assiut, Egypt.

Background And Aim: The current study investigated the effects of treatment with 300 mg/kg valproic acid on rhabdomyolysis and acute kidney injury induced by intramuscular injection of hypertonic glycerol in rats.

Methods: Four groups of male wistar rats: control and hypertonic glycerol, valproic acid and valproic acid + hypertonic glycerol treated groups were used. Blood urea nitrogen, serum creatinine, creatinine kinase (CK) and CK MB, myoglobin and renal reduced glutathione (GSH) levels were measured. Read More

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Renal involvement in Mediterranean spotted fever - clinical and histopathological data.

Med Princ Pract 2021 Mar 29. Epub 2021 Mar 29.

Background: Mediterranean spotted fever (MSF) is a tick-borne rickettsial infection endemic to the Mediterranean coastline countries. As a result of growing tourism imported cases have been registered in many non-endemic countries and regions.

Objective: We present clinical laboratory parameters and histopathological data on renal impairment in patients with MSF. Read More

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Evaluation of the acute toxicity of the extracts of var. (L.) and var. Maire in Swiss mice.

Vet World 2021 Feb 22;14(2):457-467. Epub 2021 Feb 22.

Laboratory of Biotechnology, Environment, Agri-Food, and Health LBEAS, Faculty of Sciences, University Sidi Mohamed Ben Abdellah USMBA Fez, Morocco.

Background And Aim: (L.) has been used in traditional North African and Indian medicine for the treatment of several diseases such as cancer, rheumatism, epilepsy, diabetes, and Alzheimer's disease. Despite its medical benefits, few studies have examined its toxicity. Read More

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February 2021

A Case of Cefepime-Induced Neurotoxicity: Renal Function Missing in Action.

Cureus 2021 Feb 16;13(2):e13368. Epub 2021 Feb 16.

Nephrology, Penn State Health Milton S. Hershey Medical Center, Hershey, USA.

Cefepime is a renally excreted, fourth-generation cephalosporin used in the treatment of severe abdominal, skin, soft tissue, and urinary tract infections due to its broad-spectrum coverage. Cefepime-induced neurotoxicity is a rare but serious side effect that has increased in recent years likely due to increased antibiotic use, increased drug resistance, and increased symptom recognition. While decreased glomerular filtration rate is an important risk factor for developing elevated serum cefepime levels, recent literature has suggested that a significant proportion of patients with normal renal function can also develop neurotoxicity from cefepime. Read More

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February 2021