1,188,005 results match your criteria Acute Stroke Management
J Environ Radioact 2018 Dec 12;197:116-126. Epub 2018 Dec 12.
IRSN, PSE-ENV, Fontenay aux Roses, France.
There is a need to prioritise the requirements for data to assess the radiological risk for fauna and flora, as inevitable large data gaps occur due to the large number of combinations of radionuclides and organisms for which doses need to be assessed. The potentially most important dose-forming radionuclide-pathways combinations need to be identified to optimize filling these gaps. Few attempts have been made to classify the importance of isotopes with regard to radiation protection of the environment. Read More
Environ Int 2018 Dec 12;123:282-291. Epub 2018 Dec 12.
Laboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Rio de Janeiro, RJ, Brazil.
Noroviruses are a leading cause of epidemic and pandemic acute gastroenteritis (AGE) worldwide, and contaminated food and water are important routes for its transmission. Raw sewage has been used for viral surveillance to monitor the emergence of new norovirus strains with the potential to cause epidemics. In this study, we investigated norovirus occurrence and norovirus RNA levels in 156 samples collected from May 2013 to May 2014, across three different stages (52 samples each) of a wastewater treatment plant (WWTP) in Rio de Janeiro, Brazil. Read More
Biomed Pharmacother 2018 Dec 12;110:692-699. Epub 2018 Dec 12.
Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Glycyrrhizin, a triterpenoid compound, has been reported to be an anti-inflammatory agent for the treatment of a variety of inflammatory diseases including hepatitis. However, the mechanism by which glycyrrhizin inhibits inflammation is unclear. Using a Con A-induced hepatitis model in mice, we found that administration of glycyrrhizin ameliorates Con A-induced liver injury, which manifests as reduction in the production of inflammatory cytokines IFN-γ, IL-6 and IL-17, as well as serum alanine aminotransferase (ALT). Read More
Leuk Res 2018 Nov 27;76:39-47. Epub 2018 Nov 27.
Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands.
Flow-cytometric detection of now termed measurable residual disease (MRD) in acute myeloid leukemia (AML) has proven to have an independent prognostic impact. In a previous multicenter study we developed protocols to accurately define leukemia-associated immunophenotypes (LAIPs) at diagnosis. It has, however, not been demonstrated whether the use of the defined LAIPs in the same multicenter setting results in a high concordance between centers in MRD assessment. Read More
Thromb Res 2018 Dec 6;174:40-47. Epub 2018 Dec 6.
Center for Molecular Cardiology, Laboratory for Platelet Research, University of Zurich, Schlieren, Switzerland; Department of Internal Medicine, Cantonal Hospital of Baden, Baden, Switzerland. Electronic address:
Introduction: Gut microbiota-dependent trimethylamine-N-oxide (TMAO) correlates with arterial thrombotic events including myocardial infarction and stroke, and mortality. However, the association of TMAO with recurrent venous thromboembolism (VTE) and mortality remains unknown.
Methods: TMAO plasma levels were assessed by high performance liquid chromatography in 859 patients aged ≥65 years with acute VTE and categorized into low (<2. Read More
Thromb Res 2018 Dec 8;174:27-33. Epub 2018 Dec 8.
Department of Cardiology, EA3920, University Hospital Besançon, Boulevard Fleming, 25030 Besançon, France. Electronic address:
Background: Data regarding the use of direct oral anticoagulants (DOACs) for the treatment of acute pulmonary embolism (PE) are sparse. We conducted a prospective multicentre registry study to describe patterns of DOAC prescription for the treatment of acute PE, and the associated risk of 6-month adverse events in daily practice.
Methods: We included all PE patients discharged since the availability of DOACs for the dedicated indication of acute PE treatment. Read More
Aquat Toxicol 2018 Dec 5;207:91-100. Epub 2018 Dec 5.
Climate Change Cluster, University of Technology Sydney, NSW, Australia.
Copper (Cu) is an essential micronutrient for plants and as such is vital to many metabolic processes. Nevertheless, when present at elevated concentrations, Cu can exert toxic effects on plants by disrupting protein functions and promoting oxidative stress. Due to their proximity to the urbanised estuaries, seagrasses are vulnerable to chemical contamination via industrial runoff, waste discharges and leachates. Read More
Biomed Pharmacother 2018 Dec 12;111:19-30. Epub 2018 Dec 12.
The Third Affiliate Hospital of Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address:
Bone marrow mesenchymal stem cells (BM-MSCs) are recruited to injured site for cardiac self-repairing in acute myocardial infarction (AMI), but the spontaneous mobilization of BM-MSCs is insufficient for self-repairing. Inflammation initiated by necrosis cardiomyocytes induced cardiac remodeling and depression. Given the anti-inflammatory effects of BM-MSCs and the inextricably relationship among inflammation, ventricular remodeling and depression following AMI, methods focused on enhancing BM-MSCs mobilization are promising. Read More
Virology 2018 Dec 12;528:19-29. Epub 2018 Dec 12.
Ruminant Diseases and Immunology Research Unit, National Animal Disease Center, USDA, ARS, Ames, IA 50010, USA.
Bovine viral diarrhea virus (BVDV), a ubiquitous pathogen of cattle, causes subclinical to severe acute disease. Two species of BVDV are recognized, BVDV1 and BVDV2 with BVDV1 divided into at least 21 subgenotypes and BVDV2 into 3-4 subgenotypes, most commonly using sequences from the 5' untranslated region (5' UTR). We report genomic sequencing of 8 BVDV2 isolates that did not segregate into the 2a subgenotype; but represented two additional BVDV2 subgenotypes. Read More
Curr Opin Psychol 2018 Nov 19;28:92-101. Epub 2018 Nov 19.
University of California, San Francisco, United States. Electronic address:
Both theoretical and empirical work support the notion that meditation training can improve telomere regulation, which may ultimately contribute to healthy aging. Yet, the psychological and biological mechanisms underlying these changes remain underspecified, as do the contexts and boundary conditions in which these changes occur. Here we summarize studies investigating the effects of various meditation-based interventions on telomere biology, making suggestions for future research. Read More
World Neurosurg 2018 Dec 12. Epub 2018 Dec 12.
Department of Neurosurgery, University of Louisville, 200 Abraham Flexner Hwy, Louisville, KY, U.S.A- 40202. Electronic address:
Introduction: Bundled payments offer a lump sum for management of particular conditions over a specified time period that has the potential to reduce healthcare payments. Additionally, bundled payments represent a shift toward patient-centered reimbursement that has the upside of improved care coordination among providers and may lead to improved outcomes.
Aim: To review the challenges and sources of payment variation and opportunities for restructuring bundled payments plans in context of spine surgery. Read More
Neurobiol Learn Mem 2018 Dec 12. Epub 2018 Dec 12.
Acute stress is known to modulate episodic memory, but little is known about the extent to, and the circumstances under, which stress affects encoding of item vs. inter-item associative information for words of different valences. Furthermore, the precise neuro-cognitive mechanisms underlying stress effects on episodic encoding in humans are largely unknown. Read More
Int J Pharm 2018 Dec 12. Epub 2018 Dec 12.
The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address:
Quizartinib, a second-generation FLT3 inhibitor, is in clinical development for the treatment of acute myeloid leukemia. We studied its pharmacokinetic interactions with the multidrug efflux transporters ABCB1 and ABCG2 and the multidrug metabolizing enzyme CYP3A, using in vitro transport assays and knockout and transgenic mouse models. Quizartinib was transported by human ABCB1 in vitro, and by mouse (m)Abcb1 and mAbcg2 in vivo. Read More
Brain Res Bull 2018 Dec 12. Epub 2018 Dec 12.
Scientific Clinical Specialist, Siemens Ltd., Beijing, China.
Background: Ischemic stroke is a clinically common disease requiring early treatment in the acute period of stroke onset. Such early treatment reduces the level of brain injury, promotes functional recovery, and improves long-term prognosis. Previous studies have demonstrated that, in the event of an acute ischemic stroke, low-intensity transcranial ultrasound stimulation (LITUS) can provide neuroprotection. Read More
J Ethnopharmacol 2018 Dec 12. Epub 2018 Dec 12.
Biopesticides Laboratory (LPIP), Center of Biotechnology of Sfax, University of Sfax, P.O. Box. 1177, 3018 Sfax, TUNISIA. Electronic address:
Ethnopharmacological Relevance: Emex spinosa (L.) Campd. (E. Read More
Int J Biochem Cell Biol 2018 Dec 12. Epub 2018 Dec 12.
Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden; Lund Stem Cell Center, Department of Laboratory Medicine, Lund University, Lund, Sweden; Division of Oncology, Skåne University Hospital, Lund, Sweden. Electronic address:
The receptor tyrosine kinase FLT3 is expressed almost exclusively in the hematopoietic compartment. Binding of its ligand, FLT3 ligand (FL), induces dimerization and activation of its intrinsic tyrosine kinase activity. This leads to autophosphorylation of FLT3 on several tyrosine residues which constitute high affinity binding sites for signal transduction molecules. Read More
Ann Allergy Asthma Immunol 2018 Dec 12. Epub 2018 Dec 12.
Allergy Department Hospital Universitario 12 de Octubre, Avenida de Córdoba s/n, Postal code 28041 , Madrid, Spain.
Behav Brain Res 2018 Dec 12. Epub 2018 Dec 12.
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, 23298, USA. Electronic address:
The objective of the present study is to investigate the role of α4, α5, α6 or β2 nAChR subunits in the antidepressant-like effect of bupropion. Adult male mice were treated with subcutaneous acute doses of bupropion (3 and 10 mg/kg) 30 min before the forced swim test (FST) in α4, α5, α6, or β2 nAChR subunit knockout (KO) and wild-type (WT) mice. In addition, the effects of β2* antagonist dihydro-β-erythroidine (DHβE, 3 mg/kg) on antidepressant-like effects of bupropion in C57BL/6 J mice were assessed. Read More
Neurosci Lett 2018 Dec 12. Epub 2018 Dec 12.
Isobolographic Analysis Laboratory, Institute of Rural Health, Jaczewskiego 2, 20-950 Lublin, Poland.
The aim of the study was to evaluate the impact of second generation antiepileptic drug levetiracetam (LEV) with arachidonyl-2'-chloroethylamide (ACEA) on proliferating neural precursor cells in mouse brain. Additionally, we established the relationship between treatment with ACEA in combination with LEV and hippocampal neurogenesis in mouse brain. All experiments were performed on male CB57/BL mice injected i. Read More
Prog Neuropsychopharmacol Biol Psychiatry 2018 Dec 12. Epub 2018 Dec 12.
Fondation FondaMental, Créteil, France; Faculté de Médecine, Université d'Auvergne, CMP B, CHU, EA 7280, Clermont-Ferrand Cedex 69 63003, France.
Background: Predicting psychotic relapse is one of the major challenges in the daily care of schizophrenia.
Objectives: To determine the predictors of psychotic relapse and follow-up withdrawal in a non-selected national sample of stabilized community-dwelling SZ subjects with a machine learning approach.
Methods: Participants were consecutively included in the network of the FondaMental Expert Centers for Schizophrenia and received a thorough clinical and cognitive assessment, including recording of current treatment. Read More
Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.
Mid Atlantic Retina, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA. Electronic address:
Purpose: To compare the rates of infectious endophthalmitis following intravitreal injection of ranibizumab using prefilled syringes vs. conventional preparation.
Design: Multicenter, retrospective, cohort study METHODS: All eyes receiving intravitreal injection of 0. Read More
Acta Trop 2018 Dec 12. Epub 2018 Dec 12.
Programa de Pós-Graduação em Ciências da Saúde, Departamento de Ciências Básicas em Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso, Av. Fernando Correa da Costa, n. 2367, CCBS-I, sala 82, CEP 78060-900, Cuiabá, Mato Grosso, Brazil. Electronic address:
Arboviruses have become a major public health concern in Brazil, especially after Zika virus (ZIKV) and Chikungunya virus (CHIKV) introduction, leading to massive epidemics. We conducted an investigation of arboviruses in patients with acute febrile illness for less than five days in Mato Grosso state (MT) during the period of ZIKV and CHIKV dissemination in Brazil. To achieve that, 453 human serum samples of patients suspected of Dengue (DENV), Yellow Fever (YFV), ZIKV or CHIKV collected in health units of 31 cities of MT were subjected to RT-PCR protocols for 10 flaviviruses, 5 alphaviruses and orthobunyaviruses from Simbu serogroup, nucleotide sequencing and viral isolation. Read More
J Clin Nurs 2018 Dec 15. Epub 2018 Dec 15.
Nursing Research and Practice Development, Ulster University, and South Eastern Health and Social Care Trust, Northern Ireland.
Aims And Objectives: To review published research into the staff and adult patient experience of person-centred practice in a 100% single-room environment in acute care.
Background: There has been a significant move towards the 100% single-room environment within healthcare systems. Furthermore, there has been a global move for developing person-centred practice in a range of healthcare settings. Read More
Actas Esp Psiquiatr 2018 Nov 1;46(6):242-8. Epub 2018 Nov 1.
Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin, P.R. China.
J Clin Nurs 2018 Dec 15. Epub 2018 Dec 15.
School of Nursing and Midwifery l College of Science, Health and Engineering, Latrobe University Melbourne, Victoria, Australia, 3086.
Aim And Objectives: To describe nurses' experiences of providing person-centred care (PCC) for older people on an acute medical ward.
Background: There is evidence that PCC for older people contributes to a higher quality care and increased satisfaction with care. However there is a shortness of studies providing concrete examples of what facilitates nurses providing PCC for older people in acute care. Read More
J Sci Food Agric 2018 Dec 15. Epub 2018 Dec 15.
College of Chinese Medicinal Materials, Jilin Agriculture University, Changchun, China.
Background: In China, Acanthopanax sessiliflorus is a delicious wild vegetable. It is also used to treat of inflammation and pain. Considering that chiisanoside (CSS) is the main constituent of the leaf of A. Read More
Diagn Cytopathol 2018 Dec 14. Epub 2018 Dec 14.
Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH.
Pulmonary artery intimal sarcoma is a rare aggressive intraluminal tumor often misdiagnosed as acute or chronic pulmonary thromboembolism due to its clinical presentation and radiological findings. Thus early diagnosis is very crucial and may improve patient outcome. There is limited literature on diagnosis of pulmonary artery sarcoma by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Read More
Zoonoses Public Health 2018 Dec 14. Epub 2018 Dec 14.
Wildlife and Habitat Branch, BC Ministry of Forests, Lands, Natural Resource Operations and Rural Development, Nanaimo, British Columbia, Canada.
Striped skunks (skunks) are susceptible to respiratory infection by influenza A viruses (IAV). As they are common synanthropes, maintenance of IAV in skunks could provide a source of infection for humans. We previously studied the nasal turbinates, lungs and faeces of 50 free-ranging skunks for the presence of IAV and identified two individuals with influenza A(H1N1)pdm09 infection during the 2009/2010 and 2013/2014 flu seasons. Read More
J Nurs Scholarsh 2018 Dec 15. Epub 2018 Dec 15.
Psychiatric Clinical Nurse Specialist, Landspitali University Hospital, Landspitali-The National University Hospital in Iceland, Child and Adolescent Psychiatric Division, Reykjavik, Iceland.
Purpose: Family nursing interventions, focusing on therapeutic conversations, have been found to benefit primary caregivers dealing with chronic and acute illnesses. Less is known, however, about the benefit of these interventions for partner caregivers. The aims of this study were to develop and test the Family Strengths-Oriented Therapeutic Conversation (FAM-SOTC) intervention for partner caregivers of young individuals with eating disorders (EDs). Read More
J Nurs Scholarsh 2018 Dec 15. Epub 2018 Dec 15.
Rho, Professor, University of Michigan School of Nursing, Ann Arbor, MI, USA.
Purpose: The purposes of this study were to (a) describe nurse manager (NM) leadership behaviors for evidence-based practice, NM evidence-based practice competencies, and unit climates for evidence-based practice implementation in acute care, and (b) test for differences in NMs' and staff nurses' (RNs') perceptions.
Design: A multisite cross-sectional design was used to collect data from a sample of 24 NMs and 553 RNs from 24 adult medical-surgical units in seven U.S. Read More
J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.
Department of Internal Medicine, International St. Mary's Hospital, Catholic Kwandong University, Republic of Korea.
Background: It is unclear whether obesity increases the incidence of acute pancreatitis (AP) in the general population. Further, no study has prospectively examined the associations of the risk of AP by etiology with measured body mass index (BMI) values.
Methods: 512,928 Korean participants in routine health examinations during 2002-2003 were followed up until 2013 via linkage to national hospital discharge records to assess AP incidence. Read More
J Cell Biochem 2018 Dec 14. Epub 2018 Dec 14.
Department of Cardiology, Jining No. 1 People's Hospital, Jining, Shandong, China.
Notoginsenoside R1 (NG-R1) is a major component of Panax notoginseng, which has been used clinically for the treatment of diabetic nephropathy for centuries in China. This study aimed to reveal the functional impacts and the underlying mechanisms of NG-R1 on oxygen-glucose deprivation (OGD)-injured cardiomyocytes. Rat cardiomyocyte line H9c2 and primary cardiomyocytes were subjected to OGD with or without NG-R1 treatment. Read More
J Cell Biochem 2018 Dec 14. Epub 2018 Dec 14.
Intensive Care Unit, Shengjing Hospital, Medical University, Shenyang, Liaoning, China.
Objective: We aimed to investigate the association of macrophage inflammatory protein (MIP)-1α (CCL3) expression with the severity of acute pancreatitis (AP).
Methods: The patients with AP were selected and divided into mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP) groups according to the severity of AP. The pancreatic acinar cell line Ar42 j was treated with cerulein to induce in vitro cell AP model. Read More
Hepatology 2018 Dec 14. Epub 2018 Dec 14.
UPMC Hillman Cancer Center, Pittsburgh, PA, 15213, USA.
Acetaminophen (APAP) overdose is one of the leading causes of hepatotoxicity and acute liver failure in the United States. Accumulating evidence suggests that hepatocyte necrosis plays a critical role in APAP-induced liver injury. However, the mechanisms of APAP-induced necrosis and liver injury are not fully understood. Read More
Front Med 2018 Dec 14;12(6):726-734. Epub 2018 Dec 14.
State Key Laboratory of Medical Genomics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Bromodomain-containing 4 (BRD4) has been considered as an important requirement for disease maintenance and an attractive therapeutic target for cancer therapy. This protein can be targeted by JQ1, a selective small-molecule inhibitor. However, few studies have investigated whether BRD4 influenced acute promyelocytic leukemia (APL), and whether BRD4 had interaction with promyelocytic leukemia-retinoic acid receptor α (PML/RARα) fusion protein to some extent. Read More
Gen Thorac Cardiovasc Surg 2018 Dec 14. Epub 2018 Dec 14.
Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, 1-847 Amanumacho, Omiya-ku, Saitama, 330-8503, Japan.
Background: Acute type A aortic dissection (ATAAD) is relatively uncommon in dialysis patients, and characteristics and repair outcomes are not fully understood.
Patients And Methods: Patients with ATAAD (n = 960) were divided into a dialysis group (n = 19) and non-dialysis group (n = 941), depending on whether they required dialysis for preoperative end-stage renal disease (ESRD). Hospital charts and imaging data were reviewed, and characteristics and outcomes were compared between the groups. Read More
Gen Thorac Cardiovasc Surg 2018 Dec 14. Epub 2018 Dec 14.
Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Japan.
Objective: The standard treatment of prosthetic paravalvular leakage (PVL) accompanied by heart failure or hemolytic anemia is repeat open surgery. Although favorable outcomes for transcatheter prosthetic PVL closure in patients with a high surgical risk for repeat open surgery have been reported, procedural feasibility has not been examined in Japan.
Methods: From March 2015 to November 2015, transcatheter PVL closure in mitral position was performed in four patients (age range 41-78, three females) with high surgical risk due to history of repeated surgeries, chest radiation and reconstruction of the mitral annulus after debridement of abscess owing to infective endocarditis. Read More
Ir J Med Sci 2018 Dec 14. Epub 2018 Dec 14.
Department of Anaesthesia, The Rotunda Hospital, Parnell Square, Dublin, Ireland.
Background: Rigid bronchoscopy may be used to relieve acute airway obstruction following induction of anaesthesia and is a recommended option for management of the difficult airway. The ability of anaesthetists to perform rigid bronchoscopy has not been reported. We sought to explore the acquisition of procedural skill in rigid bronchoscopy by anaesthesiologists in a manikin. Read More
Intern Emerg Med 2018 Dec 14. Epub 2018 Dec 14.
Division of Emergency Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals and Geneva University, Faculty of Medicine, Geneva, Switzerland.
Acute ethanol intoxication (AEI) is frequent in emergency departments (EDs). These patients are at risk of mistriage, and to leave the ED without being seen. This study's objective was to describe the process and performance of triage and trajectory for patients with suspected AEI. Read More
Neth Heart J 2018 Dec 14. Epub 2018 Dec 14.
Department of Cardiology, Academic Medical Centre, Location Meibergdreef, University of Amsterdam, Amsterdam, The Netherlands.
Metab Brain Dis 2018 Dec 14. Epub 2018 Dec 14.
Department of Physiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Consumption of high fat diet (HFD) is a health concern in modern societies, which participate in wide range of diseases. One underlying mechanism in the HFD mediated pathologies is disruption of insulin signaling activity. It is believed that HFD activates several stress signaling molecules such as MAPKs signaling pathway and these molecules participate in harmful effects in different cell populations including hippocampal cells. Read More
Eur Radiol 2018 Dec 14. Epub 2018 Dec 14.
Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome "Sapienza", Viale Regina Elena 324, 00161, Rome, Italy.
Objectives: To investigate the prognostic role of early post-infarction cardiac magnetic resonance (CMR) on long-term risk stratification of ST segment elevation myocardial infarction (STEMI) patients with preserved left ventricular ejection fraction (LVEF).
Methods: Seventy-seven STEMI patients treated by primary percutaneous coronary intervention (PCI) and LVEF > 50% at CMR were included. The median time between STEMI and CMR was 5 days (IQR 2-8). Read More
Aesthetic Plast Surg 2018 Dec 14. Epub 2018 Dec 14.
Breast Plastic and Reconstructive Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 33 Badachu Road, Shijingshan District, Beijing, 100144, People's Republic of China.
Background: PGGFRα preadipocytes are the major subpopulations that can regenerate into adipocytes. Two different types of macrophages exist in the fat tissue: the classically activated macrophage (M1) and the alternatively activated macrophage (M2). In this study, we investigated whether M1/M2 macrophages play distinct roles in adipogenic differentiation of PDGFRα preadipocytes. Read More
Arch Toxicol 2018 Dec 14. Epub 2018 Dec 14.
Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
Acetaminophen (APAP) is one of the most commonly used analgesics worldwide, and overdoses are associated with lactic acidosis, hepatocyte toxicity, and acute liver failure due to oxidative stress and mitochondrial dysfunction. Hepatoma cell lines typically lack the CYP450 activity to generate the reactive metabolite of APAP observed in vivo, but are still subject to APAP cytotoxicity. In this study, we employed metabolic profiling and isotope labelling approaches to investigate the metabolic impact of acute exposure to cytotoxic doses of APAP on the widely used HepG2 cell model. Read More
Rheumatol Int 2018 Dec 14. Epub 2018 Dec 14.
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
Juvenile dermatomyositis (JDM) is the most common childhood idiopathic inflammatory myopathy (IIM). It is characterized by the classic skin rash in the form of Gottron papules and heliotrope rash, and symmetric proximal muscle weakness. Renal involvement in JDM is rare which includes acute kidney injury and glomerulonephritis. Read More
Cell Mol Life Sci 2018 Dec 14. Epub 2018 Dec 14.
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, C/Nicolás Cabrera 1, Cantoblanco, 28049, Madrid, Spain.
The vasculature is the paradigm of a compartment generated by parallel cellular barriers that aims to transport oxygen, nutrients and immune cells in complex organisms. Vascular barrier dysfunction leads to fatal acute and chronic inflammatory diseases. The endothelial barrier lines the inner side of vessels and is the main regulator of vascular permeability. Read More
Mod Pathol 2018 Dec 14. Epub 2018 Dec 14.
Institute of Pathology and Nephropathology Section, University Hospital Hamburg Eppendorf, Hamburg, Germany.
Bevacizumab is a humanized monoclonal IgG1 antibody, which neutralizes vascular endothelial growth factor and is used for treating multiple cancer types. As a known and frequent adverse event, this therapy can lead to renal damage including proteinuria and nephrotic syndrome. In a retrospective approach, we analyzed 17 renal biopsies from patients receiving bevacizumab treatment. Read More
Leukemia 2018 Dec 14. Epub 2018 Dec 14.
Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Minimal residual disease (MRD) measured by PCR of clonal IgH/TCR rearrangements predicts relapse in T-cell acute lymphoblastic leukemia (T-ALL) and serves as risk stratification tool. Since 10% of patients have no suitable PCR-marker, we evaluated flowcytometry (FCM)-based MRD for risk stratification. We included 274 T-ALL patients treated in the NOPHO-ALL2008 protocol. Read More
Sci Rep 2018 Dec 14;8(1):17870. Epub 2018 Dec 14.
UW Medicine South Lake Union, University of Washington, Seattle, WA, 98109, USA.
Acute kidney injury (AKI) and chronic kidney disease (CKD) are considered early and late phases of a pathologic continuum of interconnected disease states. Although changes in gene expression patterns have recently been elucidated for the transition of AKI to CKD, the epigenetic regulation of key kidney injury related genes remains poorly understood. We used multiplex RT-qPCR, ChIP-qPCR and integrative analysis to compare transcriptional and epigenetic changes at renal disease-associated genes across mouse AKI and CKD models. Read More
Cell Mol Immunol 2018 Dec 14. Epub 2018 Dec 14.
Institute for Immunology and School of Medicine, Beijing Key Lab for Immunological Research on Chronic Diseases, Tsinghua University, 100086, Beijing, China.
Classical signaling lymphocyte activating molecule (SLAM) family receptors are abundant within many types of immune cells, whereas the nonclassical SLAM family receptors SLAMF8 and SLAMF9, which uniquely lack cytoplasmic signaling motifs, are highly expressed by myeloid cells. Due to the potential redundancy, whether these two receptors regulate macrophage function remains largely unknown. Here, we show that SLAMF8 and SLAMF9 co-regulate macrophage-mediated liver inflammation. Read More