24,951 results match your criteria Acute Rheumatic Fever


Development and implementation of the AIDA International Registry for patients with Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis syndrome.

Front Pediatr 2022 22;10:930305. Epub 2022 Jul 22.

Unit of Rheumatology, Azienda Ospedaliero-Universitaria Senese, Siena, Italy.

Objective: Aim of this paper is to illustrate the methodology, design, and development of the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to patients with the Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis (PFAPA) syndrome.

Methods: This is a physician-driven, non-population- and electronic-based registry proposed to gather real-world demographics, clinical, laboratory, instrumental and socioeconomic data from PFAPA patients. Data recruitment is realized through the on-line Research Electronic Data Capture (REDCap) tool. Read More

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Sex-Based Differences in Outcomes of Coronavirus Disease 2019 (COVID-19) in Korea.

Asian Nurs Res (Korean Soc Nurs Sci) 2022 Aug 3. Epub 2022 Aug 3.

Department of Big Data AI, Hoseo University.

Purpose: This study examined the factors affecting mortality and clinical severity score (CSS) of male and female patients with Coronavirus Disease 2019 (COVID-19) using clinical epidemiological information provided by the Korea Disease Control and Prevention Agency.

Methods: This is a retrospective observational cohort study. From January 21 to April 30, 2020, 5624 subjects who were released from quarantine or died were analyzed. Read More

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Community Advocacy and Capacity Building of Community Health Workers on Rheumatic Heart Disease in Osun State, Nigeria.

West Afr J Med 2022 Jul(7):756-760

Nigerian Heart Foundation, No. 4, Akanbi Danmola Street, Off Ribadu Road, S.W. Ikoyi, Lagos Nigeria.

Rheumatic heart disease (RHD) is one of the leading causes of cardiovascular diseases in the world. The study aimed to assess awareness and capacity building on the diagnosis and prevention of RHD among Community Health Workers (CHWs) Nigeria. It was an interventional study, where 300 CHWs from public Primary Health Care (PHC) facilities were selected pre-assessed on the diagnosis and prevention of RHD before their training on RHD. Read More

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[Acute rheumatic fever (ARF) in an adult male].

Inn Med (Heidelb) 2022 Jun 20. Epub 2022 Jun 20.

Klinik für Kardiologie, DRK Kliniken Berlin Köpenick, Salvador-Allende-Str. 2-8, 12559, Berlin, Deutschland.

Acute rheumatic fever (ARF) results from an autoimmune reaction following Streptococcus pyogenes-induced tonsilitis. It is a disease that has become uncommon in Germany and is rare in adults. Treatment recommendations are controversial in this age group. Read More

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Recurrent fulminant non-rheumatic streptococcal myocarditis proven by endomyocardial biopsy and autopsy.

J Cardiol Cases 2022 Jul 23;26(1):62-65. Epub 2022 Mar 23.

Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

A 42-year-old man with a history of acute myocarditis after streptococcal pharyngitis developed recurrent fulminant myocarditis. Endomyocardial biopsy revealed myocyte degeneration, interstitial edema, and neutrophil infiltration. The patient's cardiac function deteriorated rapidly, and he died despite mechanical circulatory support. Read More

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Effectiveness of the BNT162b2 mRNA COVID-19 Vaccine among Adolescents with Juvenile-onset Inflammatory Rheumatic Diseases.

Rheumatology (Oxford) 2022 Aug 3. Epub 2022 Aug 3.

Pediatric Rheumatology Unit, Meir Medical Center, Kfar Saba, Israel.

Objectives: Effectiveness of the BNT162b2 mRNA COVID-19 vaccine for adolescents with juvenile-onset inflammatory rheumatic diseases (IRD) is unknown. Several studies suggested attenuated immunogenicity in patients with IRD. This study evaluated the effectiveness of the BNT162b2 mRNA COVID-19 vaccine in preventing COVID-19 infection in adolescents with juvenile-onset IRD compared with controls without immune rheumatic disease. Read More

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Long-term outcomes following rheumatic heart disease diagnosis in Australia.

Eur Heart J Open 2021 Nov 9;1(3):oeab035. Epub 2021 Nov 9.

School of Population and Global Health, Clifton St Building, Clifton St, University of Western Australia, Perth, Australia.

Aims : Rheumatic heart disease (RHD) is a major contributor to cardiac morbidity and mortality globally. This study aims to estimate the probability and predictors of progressing to non-fatal cardiovascular complications and death in young Australians after their first RHD diagnosis.

Methods And Results : This retrospective cohort study used linked RHD register, hospital, and death data from five Australian states and territories (covering 70% of the whole population and 86% of the Indigenous population). Read More

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November 2021

Safety of Biologic-DMARDs in Rheumatic Musculoskeletal Disorders: A Population-Based Study over the First Two Waves of COVID-19 Outbreak.

Viruses 2022 07 1;14(7). Epub 2022 Jul 1.

Division of Rheumatology, Department of Specialist Medicine, Azienda Sanitaria Universitaria del Friuli Centrale (ASUFC), 33100 Udine, Italy.

This study aims to explore disease patterns of coronavirus disease (COVID-19) in patients with rheumatic musculoskeletal disorders (RMD) treated with immunosuppressive drugs in comparison with the general population. The observational study considered a cohort of RMD patients treated with biologic drugs or small molecules from September 2019 to November 2020 in the province of Udine, Italy. Data include the assessment of both pandemic waves until the start of the vaccination, between February 2020 and April 2020 (first), and between September 2020 and November 2020 (second). Read More

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Fever Correlation with Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP) Concentrations in Patients with Isolated Polymyalgia Rheumatica (PMR): A Retrospective Comparison Study between Hospital and Out-of-Hospital Local Registries.

Life (Basel) 2022 Jun 30;12(7). Epub 2022 Jun 30.

Katedra Reumatologii i Chorób Wewnętrznych, Klinika Chorób Wewnętrznych Reumatologii Diabetologii Geriatrii i Immunologii Klinicznej PUM, 71-457 Szczecin, Poland.

Background: Polymyalgia rheumatica (PMR) is the most common systemic inflammatory rheumatic disease affecting the elderly. Giant cell arteritis (GCA) is a granulomatous vasculitis affecting the aorta and its branches associated with PMR in up to 20% of cases. In recent studies based on university hospital registries, fever correlated with the erythrocyte sedimentation rate (ESR) but not with C-reactive protein (CRP) concentrations at the time of diagnosis in patients with isolated PMR. Read More

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Gain-of-function mutations in cause an NF-κB-mediated autoinflammatory disease: functional assessment, clinical phenotyping and disease course of patients with ROSAH syndrome.

Ann Rheum Dis 2022 Jul 22. Epub 2022 Jul 22.

Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, Maryland, USA.

Objectives: To test the hypothesis that ROSAH (retinal dystrophy, optic nerve oedema, splenomegaly, anhidrosis and headache) syndrome, caused by dominant mutation in , is an autoinflammatory disease.

Methods: This cohort study systematically evaluated 27 patients with ROSAH syndrome for inflammatory features and investigated the effect of mutations on immune signalling. Clinical, immunologic and radiographical examinations were performed, and 10 patients were empirically initiated on anticytokine therapy and monitored. Read More

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Rheumatic disorders among patients with fever of unknown origin: A systematic review and meta-analysis.

Semin Arthritis Rheum 2022 Jul 7;56:152066. Epub 2022 Jul 7.

Department of General Internal Medicine, University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.

Objectives: To conduct a systematic literature review and meta-analysis to estimate the proportion of fever of unknown origin (FUO) and inflammation of unknown origin (IUO) cases that are due to rheumatic disorders and the relative frequency of specific entities associated with FUO/IUO.

Methods: We searched PubMed and EMBASE between January 1, 2002, and December 31, 2021, for studies with ≥50 patients reporting on causes of FUO/IUO. The primary outcome was the proportion of FUO/IUO patients with rheumatic disease. Read More

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Chronic rheumatic heart disease with recrudescence of acute rheumatic fever on histology: a case report.

Eur Heart J Case Rep 2022 Jul 5;6(7):ytac278. Epub 2022 Jul 5.

Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur, J46, Old Main Building, Main Road, Observatory, Cape Town 7925, South Africa.

Background: Rheumatic heart disease (RHD) is endemic in sub-Saharan Africa where it is the leading cause of cardiovascular mortality in the young. Rheumatic heart disease results from recurrent episodes of acute rheumatic fever (ARF), which are often difficult to diagnose clinically. Acute rheumatic fever may be diagnosed based on the revised Jones Criteria 2015 for the diagnosis of ARF. Read More

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Co-designing an intervention to prevent rheumatic fever in Pacific People in South Auckland: a study protocol.

Int J Equity Health 2022 Jul 21;21(1):101. Epub 2022 Jul 21.

Department of General Practice and Primary Health Care, University of Auckland, Auckland, New Zealand.

Background: Rheumatic fever is an autoimmune condition that occurs in response to an untreated Group A Streptococcus throat or skin infection. Recurrent episodes of rheumatic fever can cause permanent damage to heart valves, heart failure and even death. Māori and Pacific people in Aotearoa New Zealand experience some of the highest rates globally, with Pacific children 80 times more likely to be hospitalised for rheumatic fever and Māori children 36 times more likely than non-Māori, non-Pacific children. Read More

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Can we diagnose acute rheumatic fever early to maximize the success of secondary prophylaxis in rheumatic heart valve disease?

Cardiovasc Res 2022 Jul;118(9):e62-e65

Center for Excellence in Vascular Biology, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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The frequency of fibromyalgia in familial Mediterranean fever and its impact on the quality of life.

Int J Rheum Dis 2022 Jul 18. Epub 2022 Jul 18.

Rheumatology Division, Physical Medicine and Rehabilitation Department, Ataturk University School of Medicine, Erzurum, Turkey.

Background And Aim: Concomitant fibromyalgia syndrome (FMS) has been known to be more frequent in patients with several rheumatic diseases. In this study, our aim was to investigate the prevalence of FMS in patients with familial Mediterranean fever (FMF), to analyze the possible factors related to this frequency, and to evaluate the impact of FMS on the functionality and quality of life (QoL) of the patients with FMF.

Patients And Methods: One hundred cases with FMF and 100 controls were included to this case-control study. Read More

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Examination of the independent contribution of rheumatic heart disease and congestive cardiac failure to the development and outcome of melioidosis in Far North Queensland, tropical Australia.

PLoS Negl Trop Dis 2022 Jul 18;16(7):e0010604. Epub 2022 Jul 18.

Department of Medicine, Cairns Hospital, Cairns, Queensland, Australia.

Background: Patients with rheumatic heart disease (RHD) and congestive cardiac failure (CCF) are believed to have an increased risk of melioidosis and are thought to be more likely to die from the infection. This study was performed to confirm these findings in a region with a high incidence of all three conditions.

Principal Findings: Between January 1998 and December 2021 there were 392 cases of melioidosis in Far North Queensland, tropical Australia; 200/392 (51. Read More

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Prevalence of Structural Heart Diseases Detected by Handheld Echocardiographic Device in School-Age Children in Iran: The SHED LIGHT Study.

Glob Heart 2022 15;17(1):39. Epub 2022 Jun 15.

Istituto Auxologico Italiano, IRCCS, Milan, Italy.

Background: Structural heart disease (SHD) has great impacts on healthcare systems, creating further public health concerns. Proper data are scant regarding the magnitude of the affected population by SHD.

Objectives: This study aimed to determine the prevalence of SHD among children and adolescents in an Iranian population. Read More

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Presence of SARS-CoV-2 antibodies in patients with COVID-19 like symptoms from the IENIMINI cohort.

Scand J Rheumatol 2022 Jul 14:1-4. Epub 2022 Jul 14.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Objective: To evaluate the relationship between reported coronavirus disease 2019 (COVID-19)-like symptoms and the presence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibodies in patients with an immune-mediated inflammatory disorder or post-solid organ transplantation (IMIDT) with and without immunosuppressive medication (imed) and controls.

Method: The IENIMINI cohort was a prospective cohort study set up in the Netherlands in March 2020, with 2 monthly (paper) or weekly (online) questionnaires about COVID-19-like symptoms. Participants from this cohort who reported these symptoms between March 2020 and November 2020 were approached for this substudy. Read More

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Population pharmacokinetic study of benzathine penicillin G administration in Indigenous children and young adults with rheumatic heart disease in the Northern Territory, Australia.

J Antimicrob Chemother 2022 Jul 13. Epub 2022 Jul 13.

Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, WA, Australia.

Background: Benzathine penicillin G (BPG) is the cornerstone of secondary prophylaxis to prevent Streptococcus pyogenes infections, which precede acute rheumatic fever (ARF). The paucity of pharmacokinetic (PK) data from children and adolescents from populations at the highest risk of ARF and rheumatic heart disease (RHD) poses a challenge for determining the optimal dosing and frequency of injections and undermines efforts to develop improved regimens.

Methods: We conducted a 6 month longitudinal PK study of young people receiving BPG for secondary prophylaxis. Read More

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Effect of bFGF gel nano-sustained-release technology on rehabilitation effect of adult heart valve replacement.

Cell Mol Biol (Noisy-le-grand) 2022 Feb 27;67(6):18-25. Epub 2022 Feb 27.

Department of Cardiovascular Surgery, Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, China.

the Due to the rapid improvement of economic level, aging and lifestyle changes, the incidence of valvular heart disease continues to increase, and the bFGF gel nano sustained-release technology plays an important role in the rehabilitation of adult heart valve replacement patients. The purpose of this article is to investigate the effect of bFGF gel nano-slow release technology on the rehabilitation effect of adult heart valve replacement patients. The research object was selected from all cases of valve replacement surgery from January 2019 to January 2020, and 216 patients were divided into experimental group and control group, the experimental group carried out the sustained release of bFGF gel nanospheres. Read More

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February 2022

Mechanism of Sevoflurane Anesthesia under Hypothermic Cardiopulmonary Bypass on Postoperative Atrial Fibrillation Rhythm in Patients Undergoing Mitral Valve Replacement.

Biomed Res Int 2022 28;2022:5312897. Epub 2022 Jun 28.

Department of Anesthesiology, Beijing Anzhen Hospital of Capital Medical University, Beijing 100029, China.

Objective: It was to investigate the mechanism of atrial fibrillation after mitral valve replacement under extracorporeal circulation in patients with rheumatic heart disease under sevoflurane anesthesia maintenance and to provide scientific and effective basis for clinical treatment.

Methods: Forty patients with rheumatic heart disease who underwent mitral valve replacement were randomly rolled into group I (sinus rhythm of propofol anesthesia, = 10), group II (atrial fibrillation rhythm of propofol anesthesia, = 10), group III (sinus rhythm of sevoflurane anesthesia, = 10), and group IV (atrial fibrillation rhythm of sevoflurane anesthesia, = 10). Inflammatory factors, free tissue of right atrium, and incidence of postoperative atrial fibrillation were compared among all groups. Read More

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VEXAS syndrome causing fever of unknown origin.

Med J Aust 2022 Aug 6;217(3):129-130. Epub 2022 Jul 6.

Royal Adelaide Hospital, Adelaide, SA.

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Characterization of an experimental model to determine streptococcal M protein-induced autoimmune cardiac and neurobehavioral abnormalities.

Immunol Cell Biol 2022 Jul 6. Epub 2022 Jul 6.

School of Science & Technology, University of New England, Armidale, NSW, Australia.

Group A streptococcal (GAS) infection is associated with a spectrum of autoimmune diseases including acute rheumatic fever/rheumatic heart disease (ARF/RHD) and neurobehavioral abnormalities. Antibodies against GAS M proteins cross-react with host tissue proteins in the heart and brain leading to the symptomatology observed in ARF/RHD. As throat carriage of Streptococcus dysgalactiae subspecies equisimilis (SDSE) has been reported to be relatively high in some ARF/RHD endemic regions compared with GAS, and both SDSE and GAS express coiled-coil surface protein called M protein, we hypothesized that streptococci other than GAS can also associated with ARF/RHD and neurobehavioral abnormalities. Read More

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From Symptoms to Diagnosis: An Observational Study of the Journey of SLE Patients in Saudi Arabia.

Open Access Rheumatol 2022 29;14:103-111. Epub 2022 Jun 29.

Department of Medicine, College of Medicine, Umm Alqura University, Makkah, Saudi Arabia.

Background And Objectives: Early diagnosis and treatment is associated with improved outcomes in patients with systemic lupus erythematosus (SLE). Studying the journey of SLE patients in Saudi Arabia is essential to direct future health-care plans.

Patients And Methods: This is a cross-sectional, multicenter study. Read More

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Risk factors for group A streptococcal pharyngitis and skin infections: A case control study.

Lancet Reg Health West Pac 2022 Sep 24;26:100507. Epub 2022 Jun 24.

Department of Public Health, University of Otago, 23A Mein Street, Newtown, Wellington 6021, New Zealand.

Background: Group A streptococcal (GAS) infections can trigger an immune-mediated response resulting in acute rheumatic fever (ARF). The role of social and environmental risk factors for GAS pharyngitis and skin infections are not well understood. This study aimed to identify factors associated with GAS pharyngitis and skin infections, and to determine if these are the same as those for ARF. Read More

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September 2022

Study of streptococcal antibody (anti-streptolysin O) among healthy children in Bangladesh.

SAGE Open Med 2022 28;10:20503121221108558. Epub 2022 Jun 28.

Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.

Objectives: The standard reference value of anti-streptolysin O (ASO) titre for diagnosing acute rheumatic fever (RF) in children is yet to be determined in Bangladesh. We aimed to measure the upper limit of the normal (ULN) of ASO titre among healthy children to determine the cut-off value for the diagnosis of RF in Bangladesh.

Methods: A total of 400 healthy children aged 5-15 years with no history of fever, sore throat and impetigo during the last 8 weeks of the study were enrolled. Read More

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Acute rheumatic fever in adult patients.

Medicine (Baltimore) 2022 Jul 1;101(26):e29833. Epub 2022 Jul 1.

Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.

Acute rheumatic fever (ARF) is considered as a disorder of children, and attacks in adults are usually a recurrence of disease acquired in the child's life. Although the incidence of ARF in children has a decreasing trend in developed countries, resurgent and sporadic epidemics still occur in adults. The first attacks of ARF in adult patients without a childhood history can lead to a diagnostic dilemma. Read More

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COVID-19 vaccine counseling and safety assessment in children and teenagers with underlying medical conditions in China: a single center study.

Hum Vaccin Immunother 2022 Jun 27:2082207. Epub 2022 Jun 27.

Department of Infectious Disease, Children's Hospital of Fudan University, Shanghai, China.

Safety concerns about novel vaccines and necessity of COVID-19 vaccination for children, especially with underlying medical conditions, are the obstacle of COVID-19 vaccination program among pediatric population. The study was conducted to investigate the vaccine hesitancy reasons among the parents, and to monitor the adverse events of inactivated COVID-19 vaccines in children and teenagers with underlying medical conditions in China. Children with underlying medical conditions encountered to the Immunization Advisory Clinic for COVID-19 vaccine counseling were enrolled. Read More

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Clinical Characteristics and Risk Factors for in-Hospital Mortality in 240 Cases of Infective Endocarditis in a Tertiary Hospital in China: A Retrospective Study.

Infect Drug Resist 2022 18;15:3179-3189. Epub 2022 Jun 18.

Department of Laboratory Medicine, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, People's Republic of China.

Purpose: This study aimed (i) to investigate the clinical characteristics and risk factors related to in-hospital mortality in patients with infective endocarditis (IE) and (ii) to compare the differences in three age groups.

Methods: A total of 240 IE cases diagnosed using the modified Duke criteria between January 2016 and December 2019 were included and retrospectively studied. Patients were stratified into three age groups: < 50 y, 50-65 y, and > 65 y. Read More

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