24,115 results match your criteria Acute Rheumatic Fever


Heart Disease and Pregnancy: The Need for a Twenty-First Century Approach to Care . . . .

Heart Lung Circ 2020 Jul 28. Epub 2020 Jul 28.

Faculty of Health and Medicine, The University of Newcastle, Newcastle, NSW, Australia; Australian Centre for Public and Population Health Research, Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia.

Pregnancy and childbirth present a specific challenge to the maternal cardiovascular system. Pre-existing cardiac diseases, or cardiac diseases that occur during pregnancy, are associated with a significant risk of morbidity and mortality for both mother and baby. In recent decades, cardiac disease has emerged as a leading cause of maternal death in most high income countries, including Australia and New Zealand. Read More

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http://dx.doi.org/10.1016/j.hlc.2020.06.021DOI Listing

[Bertolt Brecht. Did he really have rheumatic fever?]

Authors:
H Zeidler

Z Rheumatol 2020 Aug 5. Epub 2020 Aug 5.

Medizinische Hochschule Hannover, Carl-Neuberg Str. 1, 30625, Hannover, Deutschland.

The writer Bertolt Brecht (1898-1956) is known for his poems, dramas and the "epic or dialectical theater" he founded. He was retrospectively postulated to have had rheumatic fever because of heart problems and neuromuscular symptoms in his youth. Based on current rheumatological knowledge, it cannot be deduced with certainty from the available documents that Brecht had rheumatic fever. Read More

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http://dx.doi.org/10.1007/s00393-020-00846-8DOI Listing

A systematic review of radiological and histological findings of septic myocardial calcifications.

J Forensic Leg Med 2020 Jul 25;74:102026. Epub 2020 Jul 25.

Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Sapienza University of Rome, Rome, Italy.

Myocardial calcification is a life-threatening condition that is a recognised complication of ischaemic heart disease, cardiac surgery, rheumatic fever, myocarditis and sepsis. Only sparse data, reporting the clinical symptoms, the anatomo-pathological findings, the imaging findings have been published and no exhaustive analysis of all these factors exists in literature. To date, there have been 26 published cases in the medical literature in which myocardial calcifications is the consequence of a septic status. Read More

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http://dx.doi.org/10.1016/j.jflm.2020.102026DOI Listing

Development and Evaluation of a Prediction Model for Ascertaining Rheumatic Heart Disease Status in Administrative Data.

Clin Epidemiol 2020 9;12:717-730. Epub 2020 Jul 9.

School of Population and Global Health, The University of Western Australia, Perth, Australia.

Background: Previous research has raised substantial concerns regarding the validity of the International Statistical Classification of Diseases and Related Health Problems (ICD) codes (ICD-10 I05-I09) for rheumatic heart disease (RHD) due to likely misclassification of non-rheumatic valvular disease (non-rheumatic VHD) as RHD. There is currently no validated, quantitative approach for reliable case ascertainment of RHD in administrative hospital data.

Methods: A comprehensive dataset of validated Australian RHD cases was compiled and linked to inpatient hospital records with an RHD ICD code (2000-2018, n=7555). Read More

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http://dx.doi.org/10.2147/CLEP.S241588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358074PMC

Case Ascertainment on Australian Registers for Acute Rheumatic Fever and Rheumatic Heart Disease.

Int J Environ Res Public Health 2020 Jul 30;17(15). Epub 2020 Jul 30.

School of Population and Global Health, The University of Western Australia, Perth 6009, Australia.

In Australia, disease registers for acute rheumatic fever (ARF) and rheumatic heart disease (RHD) were previously established to facilitate disease surveillance and control, yet little is known about the extent of case-ascertainment. We compared ARF/RHD case ascertainment based on Australian ARF/RHD register records with administrative hospital data from the Northern Territory (NT), South Australia (SA), Queensland (QLD) and Western Australia (WA) for cases 3-59 years of age. Agreement across data sources was compared for persons with an ARF episode or first-ever RHD diagnosis. Read More

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http://dx.doi.org/10.3390/ijerph17155505DOI Listing

Active Case Finding for Rheumatic Fever in an Endemic Country.

J Am Heart Assoc 2020 Aug 29;9(15):e016053. Epub 2020 Jul 29.

Cincinnati Children's Hospital Medical Center Cincinnati OH.

Background Despite the high burden of rheumatic heart disease in sub-Saharan Africa, diagnosis with acute rheumatic fever (ARF) is exceedingly rare. Here, we report the results of the first prospective epidemiologic survey to diagnose and characterize ARF at the community level in Africa. Methods and Results A cross-sectional study was conducted in Lira, Uganda, to inform the design of a broader epidemiologic survey. Read More

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http://dx.doi.org/10.1161/JAHA.120.016053DOI Listing

Safety and immunogenicity of a primary yellow fever vaccination under low-dose methotrexate therapy-a prospective multi-centre pilot study1.

J Travel Med 2020 Jul 30. Epub 2020 Jul 30.

Department of Public Health and Global Health / Division of Infectious Diseases, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84,8001Zurich, Switzerland.

Background: More people on immunosuppression live in or wish to travel to yellow fever virus (YFV)-endemic areas. Data on the safety and immunogenicity of yellow fever vaccination (YFVV) during immunosuppression are scarce. The aim of this study was to compare the safety and immunogenicity of a primary YFVV between travellers on methotrexate and controls. Read More

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http://dx.doi.org/10.1093/jtm/taaa126DOI Listing

COVID-19 in rheumatic diseases in Italy: first results from the Italian registry of the Italian Society for Rheumatology (CONTROL-19).

Clin Exp Rheumatol 2020 Jul-Aug;38(4):748-753. Epub 2020 Jul 28.

Italian Society for Rheumatology, Milan, Italy.

Objectives: Italy was one of the first countries significantly affected by the coronavirus disease 2019 (COVID-19) epidemic. The Italian Society for Rheumatology promptly launched a retrospective and anonymised data collection to monitor COVID-19 in patients with rheumatic and musculoskeletal diseases (RMDs), the CONTROL-19 surveillance database, which is part of the COVID-19 Global Rheumatology Alliance.

Methods: CONTROL-19 includes patients with RMDs and proven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) updated until May 3rd 2020. Read More

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Determinants of COVID-19 disease severity in patients with underlying rheumatic disease.

Clin Rheumatol 2020 Jul 27. Epub 2020 Jul 27.

Rheumatology Department, Complejo Asistencial Universitario de León, Leon, Spain.

Background: Over the month of April, Spain has become the European country with more confirmed cases of COVID-19 infection, after surpassing Italy on April 2nd. The community of Castile and León in Spain is one of the most affected by COVID-19 infection and the province of León has a total of 3711 cases and 425 deaths so far. Rheumatic patients should be given special attention regarding COVID-19 infection due to their immunocompromised state resulting from their underlying immune conditions and use of targeted immune-modulating therapies. Read More

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http://dx.doi.org/10.1007/s10067-020-05301-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383119PMC

Early myocardial changes in patients undergoing rheumatic mitral valve repair versus replacement.

J Cardiovasc Surg (Torino) 2020 Aug;61(4):496-504

Faculty of Mathematics and Information Science, Shaanxi Normal University, Xi'an, China.

Background: Rheumatic mitral valve repair and replacement techniques are frequently used with excellent outcomes in experienced centers. This study aims to evaluate the impact of procedural types on left ventricular function in quinquagenarians.

Methods: Between January 2018 and September 2019, patients with severe rheumatic mitral stenosis were prospectively recruited. Read More

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http://dx.doi.org/10.23736/S0021-9509.20.11212-6DOI Listing

Cardiovascular health research, training, and capacity building for the eradication of rheumatic fever and rheumatic heart disease in our lifetime: the inaugural Bongani Mayosi Memorial Lecture.

Authors:
George A Mensah

Lancet Glob Health 2020 Aug;8(8):e1098-e1100

Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/S2214-109X(20)30297-7DOI Listing

American College of Rheumatology Clinical Guidance for Pediatric Patients with Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 and Hyperinflammation in COVID-19. Version 1.

Arthritis Rheumatol 2020 Jul 23. Epub 2020 Jul 23.

Division of Rheumatology, Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

Objective: To provide guidance on the management of Multisystem Inflammatory Syndrome in Children (MIS-C), a condition characterized by fever, inflammation, and multiorgan dysfunction that manifests late in the course of SARS-CoV-2 infection. The Task Force also provided recommendations for children with hyperinflammation during COVID-19, the acute, infectious phase of SARS-CoV-2 infection.

Methods: The Task Force was composed of 9 pediatric rheumatologists, 2 adult rheumatologists, 2 pediatric cardiologists, 2 pediatric infectious disease specialists, and 1 pediatric critical care physician. Read More

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http://dx.doi.org/10.1002/art.41454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405113PMC

Subcutaneous administration of benzathine benzylpenicillin G has favourable pharmacokinetic characteristics for the prevention of rheumatic heart disease compared with intramuscular injection: a randomized, crossover, population pharmacokinetic study in healthy adult volunteers.

J Antimicrob Chemother 2020 Jul 22. Epub 2020 Jul 22.

Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Western Australia, Australia.

Background: Benzathine penicillin G has been used as monthly deep intramuscular (IM) injections since the 1950s for secondary prevention of acute rheumatic fever and rheumatic heart disease (RHD). Injection frequency and pain are major programmatic barriers for adherence, prompting calls for development of better long-acting penicillin preparations to prevent RHD. We hypothesized that subcutaneous (SC) administration of benzathine penicillin G could delay penicillin absorption when compared with IM injections. Read More

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http://dx.doi.org/10.1093/jac/dkaa282DOI Listing

Colchicine ameliorates the chronic inflammatory state in patients with chronic rheumatic valvular heart disease: a pilot study.

Egypt Heart J 2020 Jul 16;72(1):42. Epub 2020 Jul 16.

Department of Cardiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Background: Inflammation is an important contributor to the pathogenesis of rheumatic heart disease (RHD). High serum levels of C-reactive protein (CRP) and interleukin-6 (IL-6) are commonly seen in patients with chronic (RHD) and indicate the presence of a chronic inflammatory state. The aim of this study was to assess the effect of colchicine as anti-inflammatory drug on the serum levels of the inflammatory markers (CRP) and (IL-6) in patients with chronic (RHD). Read More

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http://dx.doi.org/10.1186/s43044-020-00080-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364777PMC

[48-Year-Old Triathlete with Severe COVID-19 Pneumonia: Successful and Safe Treatment with Oxygen and CPAP].

Pneumologie 2020 Jul 16;74(7):417-422. Epub 2020 Jul 16.

Stiftung Krankenhaus Bethanien Moers, Medizinische Klinik 3, Klinik für Lungen- und Bronchialheilkunde, Allergologie, Immunologie, Zentrum für Schlafmedizin und Beatmungsmedizin, Lungen- und Thoraxzentrum Nordrhein, Moers.

We present the case of a 48-year old man, a triathlet, with severe COVID-19 and extensive bilateral pneumonia. On day 7 since onset of symptoms, the patient had fever, cough, rheumatic pain, dyspnea as well as severe hypoxemic respiratory failure (PaO 49,9 mmHg, PaCO 35,7 mmHg, Horovitz-Index 130). CT of the lung showed extensive bilateral ground glass opacities. Read More

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http://dx.doi.org/10.1055/a-1200-3336DOI Listing

Systematic Review and Meta-analysis of the Prevalence of Group A Streptococcal Clusters in Africa To Inform Vaccine Development.

mSphere 2020 Jul 15;5(4). Epub 2020 Jul 15.

AFROStrep Research Group, Department of Medicine, Faculty of Health Sciences, University of Cape Town & Groote Schuur Hospital, Cape Town, South Africa

An -cluster based system was proposed as a standard typing scheme to facilitate and enhance future studies of group A (GAS) epidemiological surveillance, M protein function, and vaccine development strategies. We provide an evidence-based distribution of GAS clusters in Africa and assess the potential coverage of the new 30-valent vaccine in terms of an cluster-based approach. Two reviewers independently assessed studies retrieved from a comprehensive search and extracted relevant data. Read More

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http://dx.doi.org/10.1128/mSphere.00429-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364215PMC

Mixed results with baricitinib in biological-resistant adult-onset Still's disease and undifferentiated systemic autoinflammatory disease.

RMD Open 2020 Jul;6(2)

Institue of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK

This clinical case series describes our experience with the use of Janus kinase 1/2 inhibitor baricitinib in two patients suffering from refractory adult-onset Still's disease (AOSD) as well as in one case suffering from AOSD-like autoinflammatory disease in the context of myelodysplastic syndrome. All patients suffered from disease non-responsive to conventional Disease-modifying antirheumatic drugs (DMARDs) as well as biological therapies including interleukin (IL)-1 and IL-6 blockade, relying instead on high daily doses of prednisolone. We also report the first case of infection following baricitinib use. Read More

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http://dx.doi.org/10.1136/rmdopen-2020-001246DOI Listing

Adult-Onset Still's Disease: Typical Presentation, Delayed Diagnosis.

Cureus 2020 Jun 8;12(6):e8510. Epub 2020 Jun 8.

Internal Medicine, Hospital Senhora Da Oliveira, Guimarães, PRT.

Adult-onset Still's disease (AOSD) is an uncommon auto-inflammatory disease of unknown etiology, with a classical triad of fever, arthritis, and evanescent rash. Its low prevalence and lack of specific guidelines contribute to frequent delays in diagnosis and treatment. Clinical manifestations vary greatly between mainly systemic or articular symptoms and the clinical pattern between monocyclic, polycyclic, or chronic illness. Read More

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http://dx.doi.org/10.7759/cureus.8510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346332PMC

Mechanistic implications of altered protein expression in rheumatic heart disease.

Heart Fail Rev 2020 Jul 11. Epub 2020 Jul 11.

Division of Cardiology, Department of Medicine, Faculty of Health Sciences and Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.

Rheumatic heart disease (RHD) is a major cause of cardiovascular morbidity and mortality in low- and middle-income countries, where living conditions promote spread of group A β-haemolytic streptococcus. Autoimmune reactions due to molecular mimicry of bacterial epitopes by host proteins cause acute rheumatic fever (ARF) and subsequent disease progression to RHD. Despite knowledge of the factors that predispose to ARF and RHD, determinants of the progression to valvular damage and the molecular events involved remain incompletely characterised. Read More

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http://dx.doi.org/10.1007/s10741-020-09993-1DOI Listing

Acute Rheumatic Fever: Unusual Presentation With Abdominal Pain and Acute Meningoencephalitis in a 10-Year-Old Boy.

J Clin Rheumatol 2020 Jul 7. Epub 2020 Jul 7.

From the Department of Pediatric Infectious Diseases, University Hospital for Infectious Diseases "Dr. Fran Mihaljević".

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http://dx.doi.org/10.1097/RHU.0000000000001462DOI Listing
July 2020
1.245 Impact Factor

Neurological manifestations of adult-onset Still's disease-case-based review.

Clin Rheumatol 2020 Jul 9. Epub 2020 Jul 9.

Department of Internal Medicine of Centro Hospitalar Barreiro-Montijo EPE, Barreiro, Portugal.

Adult-onset Still's disease (AOSD) is a rare inflammatory disorder in which pathophysiology is yet to be fully understood. We report the case of a 66-year-old male that presents with fever, arthralgia, and laboratory abnormalities suggestive of a systemic inflammatory disease. During a diagnostic workout, the patient developed neurological symptoms, namely a sudden confounding syndrome and hearing loss that improved with corticosteroid therapy. Read More

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http://dx.doi.org/10.1007/s10067-020-05244-8DOI Listing

Rheumatic Fever Licks at the Joints, but Bites at the Heart.

Cardiology 2020 8;145(8):529-532. Epub 2020 Jul 8.

Department of Medicine, Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA,

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http://dx.doi.org/10.1159/000508659DOI Listing

Incidence of acute rheumatic fever and rheumatic heart disease in Melbourne, Australia from 1937 to 2013.

J Paediatr Child Health 2020 Jul 8. Epub 2020 Jul 8.

Tropical Diseases Research Group, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.

Aim: Acute rheumatic fever (ARF) most commonly presents in children aged 5-14 years old. Lifelong rheumatic heart disease (RHD) can result. This study investigated time trends in ARF and RHD using inpatient data from the Royal Children's Hospital, Melbourne (RCH). Read More

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http://dx.doi.org/10.1111/jpc.14950DOI Listing

Hyperendemic rheumatic heart disease in a remote Australian town identified by echocardiographic screening.

Med J Aust 2020 Aug 6;213(3):118-123. Epub 2020 Jul 6.

Royal Darwin Hospital, Darwin, NT.

Objectives: Using echocardiographic screening, to estimate the prevalence of rheumatic heart disease (RHD) in a remote Northern Territory town.

Design: Prospective, cross-sectional echocardiographic screening study; results compared with data from the NT rheumatic heart disease register.

Setting, Participants: People aged 5-20 years living in Maningrida, West Arnhem Land (population, 2610, including 2366 Indigenous Australians), March 2018 and November 2018. Read More

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http://dx.doi.org/10.5694/mja2.50682DOI Listing

Calcineurin Inhibitor-Based Immunosuppression and COVID-19: Results from a Multidisciplinary Cohort of Patients in Northern Italy.

Microorganisms 2020 Jun 30;8(7). Epub 2020 Jun 30.

Department of Respiratory Diseases, University of Pavia and IRCCS Policlinico S. Matteo Foundation of Pavia, 27100 Pavia, Italy.

The role of immunosuppression in SARS-CoV-2-related disease (COVID-19) is a matter of debate. We here describe the course and the outcome of COVID-19 in a cohort of patients undergoing treatment with calcineurin inhibitors. In this monocentric cohort study, data were collected from the COVID-19 outbreak in Italy up to April 28 2020. Read More

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http://dx.doi.org/10.3390/microorganisms8070977DOI Listing

Chemical composition of the essential oils of four Polyalthia species from Malaysia.

Z Naturforsch C J Biosci 2020 Jul 7. Epub 2020 Jul 7.

Department of Mathematics, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris (UPSI), 35900,Tanjong Malim, Perak, Malaysia.

Polyalthia is one of the largest genera in the Annonaceae family, and has been widely used in folk medicine for the treatment of rheumatic fever, gastrointestinal ulcer, and generalized body pain. The present investigation reports on the extraction by hydrodistillation and the composition of the essential oils of four Polyalthia species (P. sumatrana, P. Read More

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http://dx.doi.org/10.1515/znc-2020-0097DOI Listing

Takayasu arteritis in a patient diagnosed with acute rheumatic fever presenting with carditis: Is it a coincidental association or an aetiological relationship?

J Paediatr Child Health 2020 Jul 4. Epub 2020 Jul 4.

Faculty of Medicine, Department of Pediatric Cardiology, Eskisehir Osmangazi University, Eskisehir, Turkey.

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http://dx.doi.org/10.1111/jpc.14992DOI Listing

Acute rheumatic fever in south-east of Turkey: clinical features and epidemiological evaluation of the patients over the last 25 years.

Cardiol Young 2020 Jul 2:1-9. Epub 2020 Jul 2.

Department of Pediatric Cardiology, Faculty of Medicine, Çukurova University, Adana, Turkey.

This study evaluates clinical and epidemiological features of acute rheumatic fever using the data of last 25 years in our hospital in south-east of Turkey. The medical records of 377 patients with acute rheumatic fever admitted to Pediatric Cardiology Department of Çukurova University during 1993-2017 were retrospectively analysed. Two hundred and six patients were admitted between 1993 and 2000, 91 between 2001 and 2008, and 80 between 2009 and 2017. Read More

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http://dx.doi.org/10.1017/S1047951120001596DOI Listing

[Diagnosis and treatment of acute tonsillopharyngitis. Consensus document update].

An Pediatr (Barc) 2020 Jun 27. Epub 2020 Jun 27.

Sociedad Española de Pediatría Extrahospitalaria y Atención Primaria (SEPEAP).

An update of the Spanish consensus document on the diagnosis and treatment of acute tonsillopharyngitis is presented. Clinical scores should not be used to prescribe antibiotics, unless microbiological tests are not available or there is a child at risk of rheumatic fever. There is no score better than those set out in the previous consensus. Read More

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http://dx.doi.org/10.1016/j.anpedi.2020.05.004DOI Listing

Diagnosis of rheumatic fever: the need for a better test.

Arch Dis Child 2020 Jun 29. Epub 2020 Jun 29.

Tropical Diseases Research Group, Murdoch Children's Research Institute, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia

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http://dx.doi.org/10.1136/archdischild-2020-318970DOI Listing

Cross-sectional study of population-specific streptococcal antibody titres in Uganda.

Arch Dis Child 2020 Jun 29. Epub 2020 Jun 29.

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA

Objective: Despite substantial variation of streptococcal antibody titres among global populations, there is no data on normal values in sub-Saharan Africa. The objective of this study was to establish normal values for antistreptolysin O (ASO) and antideoxyribonuclease B (ADB) antibodies in Uganda.

Design: This was an observational cross-sectional study. Read More

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http://dx.doi.org/10.1136/archdischild-2020-318859DOI Listing

Coronavirus disease 2019 (COVID-19) in a patient with ankylosing spondylitis treated with secukinumab: a case-based review.

Rheumatol Int 2020 Jun 26. Epub 2020 Jun 26.

Department of Physical Medicine and Rehabilitation, Cukurova University Faculty of Medicine, Adana, Turkey.

Severe acute respiratory syndrome coranovirus-2 (SARS-CoV-2) infection has become an important health-care issue worldwide. The coronavirus disease 2019 (COVID-19) has also raised concerns among patients with inflammatory rheumatic conditions and their treating physicians. There are emerging data regarding the potential risks of SARS-CoV-2 for this particular patient group. Read More

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http://dx.doi.org/10.1007/s00296-020-04635-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319213PMC

Severe COVID-19, Another Piece in the Puzzle of the Hyperferritinemic Syndrome. An Immunomodulatory Perspective to Alleviate the Storm.

Front Immunol 2020;11:1130. Epub 2020 May 28.

Division of Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

The coronavirus disease 2019 (COVID-19), an acute respiratory disease caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has been declared as a worldwide public health emergency. Interestingly, severe COVID-19 is characterized by fever, hyperferritinemia, and a hyper-inflammatory process with a massive release of pro-inflammatory cytokines, which may be responsible for the high rate of mortality. These findings may advocate for a similarity between severe COVID-19 and some challenging rheumatic diseases, such as adult onset Still's disease, secondary hemophagocytic lymphohistiocytosis, and catastrophic anti-phospholipid syndrome, which have been included in the "hyperferritinemic syndrome" category. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270352PMC

Sydenham chorea in a12- year old Saudi girl.

eNeurologicalSci 2020 Sep 6;20:100246. Epub 2020 Jun 6.

Radiology Department, Al- Azhar University, Egypt.

Sydenham chorea (SC) is the most common acquired cause of chorea in children. (SC) is the neurological manifestation of rheumatic fever. Rheumatic fever is still reported in Saudi Arabia, although less frequently. Read More

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http://dx.doi.org/10.1016/j.ensci.2020.100246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296341PMC
September 2020

New guidelines for diagnosis of rheumatic fever; do they apply to all populations?

Turk J Pediatr 2020 ;62(3):411-423

Department of Critical Care, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background And Objectives: To evaluate the efficacy of recently updated Jones criteria for diagnosis of rheumatic fever in high incidence populations like Egypt.

Methods: Clinical data of 891 Egyptian patients with rheumatic fever, aged 5-15 years in a highly specialized rheumatic fever clinic were reviewed retrospectively from March 2014 to March 2016. Discriminant analysis was used to detect the most effective predictors for diagnosis of rheumatic fever in our patients incorporating echocardiographic criteria. Read More

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http://dx.doi.org/10.24953/turkjped.2020.03.008DOI Listing
January 2020

Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016.

BMC Infect Dis 2020 Jun 18;20(1):428. Epub 2020 Jun 18.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang Province, China.

Background: To explore the trends in epidemiology and the risk factors related to the prognosis of infective endocarditis in a tertiary hospital over the past ten years.

Methods: A retrospective cohort study was performed. A total of 407 consecutive patients who were admitted with infective endocarditis were included. Read More

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http://dx.doi.org/10.1186/s12879-020-05153-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301995PMC

A Case of Cytomegalovirus-Induced Hemophagocytic Lymphohistiocytosis in a Patient with an Underlying Rheumatic Disease.

Cureus 2020 May 15;12(5):e8130. Epub 2020 May 15.

Rheumatology, Temple University Hospital, Philadelphia, USA.

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition caused by overproduction of inflammatory cytokines and overactivation of macrophages that can progress to multiorgan dysfunction and failure. Although there are guidelines that attempt to recognize the condition in its early stage, diagnosis can be very challenging due to heterogeneous presentations of HLH. Symptoms and clinical findings include fever, neurologic complaints, respiratory issues, liver dysfunction, cytopenias, amongst others most of which are not specific to HLH. Read More

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http://dx.doi.org/10.7759/cureus.8130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294891PMC

Macrophage activation syndrome as a complication of dermatomyositis: A case report.

World J Clin Cases 2020 Jun;8(11):2339-2344

Department of Dermatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.

Background: Macrophage activation syndrome (MAS) can be a fatal complication of rheumatic disorders, which occurs most commonly in patients with systemic juvenile idiopathic arthritis or systemic lupus erythematosus. It has rarely been reported in patients with dermatomyositis. Here, we describe a fatal case of MAS that developed in an adult patient with dermatomyositis. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i11.2339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281037PMC

Complicated skin and soft tissue infections in remote indigenous communities.

Intern Med J 2020 Jun;50(6):752-754

Menzies School of Health Research, Darwin, Northern Territory, Australia.

The burden and consequences of skin infections for remote living indigenous people are high. While skin infections are recognised as an antecedent to conditions such as acute rheumatic fever in children, data are limited concerning skin infection complications such as cellulitis, abscesses and osteomyelitis in older children and adults. In a 1-year retrospective audit of 439 patients presenting to two remote health clinics, 330/439 (75%) patients presented with a skin infection and 18 (4%) developed a complication. Read More

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http://dx.doi.org/10.1111/imj.14858DOI Listing

SARS-CoV-2 infection in patients with autoimmune rheumatic diseases in northeast Italy: A cross-sectional study on 916 patients.

J Autoimmun 2020 08 8;112:102502. Epub 2020 Jun 8.

Division of Rheumatology, Department of Medicine DIMED, University of Padua, Italy. Electronic address:

Background: Whether patients with autoimmune rheumatic diseases (ARD) have a higher risk for SARS-CoV-2 infection (COVID-19) and how SARS-CoV-2 pandemic impacts on adherence to therapy has not been fully elucidated. We assessed the rate and clinical presentation of COVID-19, and adherence to therapy in a large cohort of patients with ARD followed-up in a tertiary University-Hospital in Northeast Italy.

Methods: Between April 9th and April 25th 2020, after SARS-CoV-2 infection peak, a telephone survey investigating the impact of COVID-19 on patients with systemic lupus erythematosus (SLE), systemic sclerosis (SSc), rheumatoid arthritis (RA), ANCA-associated vasculitis (AAV), and idiopathic inflammatory myopathies (IIM) was administered. Read More

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http://dx.doi.org/10.1016/j.jaut.2020.102502DOI Listing

Characteristics of Children with Acute Rheumatic Carditis from a High-Incidence Region: Importance of Unexplained Worsening of Functional Class.

Cardiology 2020 11;145(8):522-528. Epub 2020 Jun 11.

Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.

Background: Acute rheumatic fever (ARF) and acute rheumatic carditis (ARC) continue to be a major public health problem in developing countries.

Objective: To study the characteristics of children with ARC being treated at a tertiary centre.

Methods And Results: We studied 126 children (mean age 10. Read More

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http://dx.doi.org/10.1159/000508035DOI Listing
June 2020
2.044 Impact Factor

Rheumatic fever recurrences in New Zealand 2010-14.

N Z Med J 2020 06 12;133(1516):47-57. Epub 2020 Jun 12.

Consultant Paediatric Cardiologist, Green Lane Paediatric & Congenital Cardiac Services, Starship Children's Hospital and Honorary Clinical Associate Professor, University of Auckland, Auckland.

Aim: To describe the epidemiology and clinical characteristics of recurrences of acute rheumatic fever (ARF) in New Zealand 2010-14.

Method: Retrospective hospital chart review for ARF with repeat hospital admissions from 2010-14, to identify recurrences of ARF. Definitions of recurrence as per NZ Heart Foundation Guidelines. Read More

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Screening for rheumatic heart disease: The reliability of anterior mitral valve leaflet thickness measurement.

Echocardiography 2020 Jun 10;37(6):808-814. Epub 2020 Jun 10.

Faculty of Medicine and Health Sciences, Department of Medicine, Division of Cardiology, Tygerberg Academic Hospital and University of Stellenbosch, Cape Town, South Africa.

Background: Studies determining the reliability of the World Heart Federation (WHF) anterior mitral valve leaflet (AMVL) measurement are limited by the introduction of bias in their test-retest analyses. This study sought to determine the reliability of the current AMVL measurement while controlling for systematic bias.

Methods: Retrospective analysis of echocardiographic data from 16 patients with previous acute rheumatic fever was performed. Read More

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http://dx.doi.org/10.1111/echo.14751DOI Listing

School-Based Streptococcal A Sore-Throat Treatment Programs and Acute Rheumatic Fever Amongst Indigenous Māori: A Retrospective Cohort Study.

Pediatr Infect Dis J 2020 Jun 3. Epub 2020 Jun 3.

From the Pediatric Department, University of Auckland, Auckland, New Zealand.

Background: Acute rheumatic fever (ARF) predominantly affects indigenous Māori schoolchildren in Bay of Plenty region, and more so male Māori students, especially when socioeconomically deprived. We evaluated the effectiveness of strategies for reducing ARF with group A streptococcal pharyngitis treatment in 2011-18.

Methods: We retrospectively assessed outcomes of 3 open cohorts of Māori schoolchildren receiving different interventions: Eastern Bay rural Cohort 1, mean deprivation decile 9. Read More

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http://dx.doi.org/10.1097/INF.0000000000002770DOI Listing

Implications of COVID-19 in pediatric rheumatology.

Rheumatol Int 2020 08 4;40(8):1193-1213. Epub 2020 Jun 4.

Division of Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, 06100, Turkey.

COVID-19 (coronavirus disease 2019) pandemic caused by SARS-CoV-2, is a global public health issue threatening millions of lives worldwide. Although the infection is mild in most of the affected individuals, it may cause severe clinical manifestations such as acute respiratory distress syndrome or cytokine storm leading to death. Children are affected less, and most experience a milder disease. Read More

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http://dx.doi.org/10.1007/s00296-020-04612-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270517PMC

Why Did the Original Jones Criteria Not Emphasize Streptococcal Infection?

Am J Med Sci 2020 06 10;359(6):317-324. Epub 2020 Feb 10.

Virginia H. Rogers Professor of Pediatric Infectious Diseases, Northwestern University Feinberg School of Medicine, Division of Pediatric Infectious Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois. Electronic address:

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http://dx.doi.org/10.1016/j.amjms.2020.02.001DOI Listing

Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children.

Ann Intensive Care 2020 Jun 1;10(1):69. Epub 2020 Jun 1.

Pediatric Intensive Care Unit, Necker-Enfants-Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris University, EA7323, 75006, Paris, France.

Background: A recent increase in children admitted with hypotensive shock and fever in the context of the COVID-19 outbreak requires an urgent characterization and assessment of the involvement of SARS-CoV-2 infection. This is a case series performed at 4 academic tertiary care centers in Paris of all the children admitted to the pediatric intensive care unit (PICU) with shock, fever and suspected SARS-CoV-2 infection between April 15th and April 27th, 2020.

Results: 20 critically ill children admitted for shock had an acute myocarditis (left ventricular ejection fraction, 35% (25-55); troponin, 269 ng/mL (31-4607)), and arterial hypotension with mainly vasoplegic clinical presentation. Read More

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http://dx.doi.org/10.1186/s13613-020-00690-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266128PMC