1,126 results match your criteria Acute Retinal Necrosis


Epstein-Barr virus retinitis in an immunocompromised child: A case report.

Eur J Ophthalmol 2020 May 27:1120672120926855. Epub 2020 May 27.

Department of Ophthalmology, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Introduction: The Epstein-Barr virus is a rare causative pathogen identified in the posterior segment. The majority of cases were presented with a serious condition of acute retinal necrosis, and most of these eyes had poor outcomes. The clinical features and effective treatment options for this condition are still unclear. Read More

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http://dx.doi.org/10.1177/1120672120926855DOI Listing

[The effects and mechanism of baicalin in a mouse acute hypertensive glaucoma model].

Zhonghua Yan Ke Za Zhi 2020 May;56(5):376-382

Zhongshan Ophthalmic Center, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Guangzhou 510060, China.

To explore the potential neuroprotection effects and associated mechanism of baicalin in a rodent acute hypertensive glaucoma model and oxygen-glucose deprivation/reperfusion (OGD/R) induced retinal ganglion cell (RGC) injury. Experiment research. A rapid and substantial elevation of intraocular pressure was performed to establish an acute hypertensive glaucoma model, and retinal thickness was assessed at 1, 3, 5, and 7 days. Read More

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http://dx.doi.org/10.3760/cma.j.cn112142-20200107-00011DOI Listing

Outer retinal involvement in N-methyl-D-aspartate-induced inner retinal injury in rabbits assessed by optical coherence tomography.

J Toxicol Sci 2020 ;45(5):261-269

Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd.

This study was aimed to investigate morphological alteration of the retina with N-methyl-D-aspartate (NMDA)-induced injury in rabbits by optical coherence tomography (OCT). The right and left eyes of a total of 12 rabbits received single-intravitreal injection of vehicle and NMDA, respectively. Four out of the 12 animals underwent OCT and quantification of plasma microRNA repeatedly (4, 48, and 168 hr after dosing), followed by ocular histopathology at the end of the study. Read More

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http://dx.doi.org/10.2131/jts.45.261DOI Listing
January 2020

Viral Loads in Ocular Fluids of Acute Retinal Necrosis Eyes Infected by Varicella-Zoster Virus Treated with Intravenous Acyclovir Treatment.

J Clin Med 2020 Apr 22;9(4). Epub 2020 Apr 22.

Department of Ophthalmology, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.

Acute retinal necrosis (ARN) is a rare viral endophthalmitis, and human herpesvirus is the principal pathogen. Early diagnosis and treatment are critical to avoid visual impairment by ARN, and pars plana vitrectomy (PPV) is required in advanced cases. In this study, we evaluated the transition of viral load in ocular fluids of ARN eyes with varicella-zoster virus (VZV) after intravenous acyclovir treatment. Read More

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http://dx.doi.org/10.3390/jcm9041204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230916PMC

Visual outcome and poor prognostic factors in acute retinal necrosis syndrome.

Graefes Arch Clin Exp Ophthalmol 2020 Apr 23. Epub 2020 Apr 23.

Department of Ophthalmology, Jules-Gonin Eye Hospital, University of Lausanne, Fondation Asile des Aveugles, Lausanne, Switzerland.

Objective: To evaluate the impact of selected clinical parameters on the mid-/long-term visual outcome of patients with acute retinal necrosis (ARN) DESIGN: A retrospective cohort study METHODS: SETTING: Two University Hospitals (Parma, Italy; Lausanne, Switzerland).

Participants: Thirty-nine non-HIV patients (39 eyes) with ARN, as confirmed by polymerase chain reaction on intraocular samples. The following potential predictors were tested using linear regression models: age, sex, etiology, best-corrected visual acuity (BCVA) on admission, delay between ARN symptom onset and treatment initiation, and surgery (performed or not). Read More

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http://dx.doi.org/10.1007/s00417-020-04701-zDOI Listing

[Retinal toxicity study of intravitreal ganciclovir in albino rabbit].

Zhonghua Yan Ke Za Zhi 2020 Apr;56(4):279-285

Department of Ophthalmology, Peking Union Medical Academy of Medical Sciences, Beijing 100730, China.

To elevated the retinal toxicity of intravitreal ganciclovir in albino rabbit eyes. Experimental study. Twenty-four New Zealand albino rabbits (forty-eight eyes) were divided into four groups by random. Read More

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http://dx.doi.org/10.3760/cma.j.cn112142-20190506-00254DOI Listing

Acute lymphocytic leukemia masquerading as acute retinal necrosis.

Am J Ophthalmol Case Rep 2020 Jun 24;18:100629. Epub 2020 Feb 24.

Byers Eye Institute at Stanford University, 2370 Watson Court Suite 200, Palo Alto, CA, 94303, United States.

Purpose: To report a case of B-cell acute lymphocytic leukemia (ALL) relapse presenting as acute retinal necrosis.

Observations: An 11-year old boy with history of B-cell ALL undergoing maintenance therapy presented with a three-month history of intermittent blurry vision and pain in the right eye when a routine lumbar puncture indicated an elevated lymphoblast-predominant white blood cell count. Bone marrow biopsy revealed 42% lymphoblasts, confirming ALL relapse. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125310PMC

Effect of phenytoin on retinal ganglion cells in acute isolated optic neuritis.

Neurol Sci 2020 Mar 24. Epub 2020 Mar 24.

Farabi Eye Hospital, Tehran University of Medical science, Qazvin Sq, Tehran, Iran.

Objective: Phenytoin has been shown to reduce the peripapillary retinal nerve fiber layer (pRNFL) loss in optic neuritis (ON). We evaluated the effects of phenytoin on retinal ganglion layers and visual outcomes of newly diagnosed acute ON.

Methods: A randomized, placebo-controlled trial was conducted in a tertiary referral eye hospital and patients with the first episode of typical demyelinating ON, without any history of multiple sclerosis were randomly assigned to phenytoin or placebo. Read More

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http://dx.doi.org/10.1007/s10072-020-04360-2DOI Listing

Immune Cell Status and Cytokines Profiles in Patients with Acute Retinal Necrosis.

Ocul Immunol Inflamm 2020 Mar 11:1-7. Epub 2020 Mar 11.

Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.

: To assess the immune status of acute retinal necrosis (ARN) patients and to investigate the immune cell types involved in the immunopathogenesis.: Peripheral blood and intraocular fluid were collected from 17 ARN patients and 9 control subjects. The Percentage of immune cells was measured using flow cytometry, levels of complement and antibodies were determined by rate nephelometry, and cytokine levels in the serum and aqueous humor (AH) were detected using cytokine quantitative chips. Read More

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http://dx.doi.org/10.1080/09273948.2020.1734214DOI Listing

Bilateral acute retinal necrosis caused by two separate viral etiologies.

Am J Ophthalmol Case Rep 2020 Jun 28;18:100636. Epub 2020 Feb 28.

Retina Service, Department of Ophthalmology, University of Pittsburgh Medical Center, 203 Lothrop Street, Pittsburgh, PA, USA.

Purpose: To describe an unusual case of bilateral acute retinal necrosis (ARN) that was caused by varicella zoster virus in one eye and Epstein-Barr virus in the fellow eye.

Observations: A 67-year-old immunocompromised man presented with ARN in the left eye following a dermatomal vesicular rash, with an aqueous sample positive for varicella zoster virus. Four months later, the patient presented with panuveitis and serous retinal detachment in the right eye, with vitreous sample positive for Epstein-Barr virus and negative for varicella zoster, herpes simplex, and cytomegalovirus. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057152PMC

Seasonality of Acute Retinal Necrosis.

J Ophthalmic Vis Res 2020 Jan-Mar;15(1):53-58. Epub 2020 Feb 2.

Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Purpose: To study the seasonal variability in the occurrence of acute retinal necrosis (ARN) in a series of polymerase chain reaction (PCR)-positive patients.

Methods: Consecutive patients clinically diagnosed with ARN and a positive PCR result of aqueous humor during a seven-year period were studied retrospectively. Patients' demographics, causative viral agent(s), and the date of disease onset were extracted from medical records. Read More

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http://dx.doi.org/10.18502/jovr.v15i1.5944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001010PMC
February 2020

Concomitant herpetic keratitis and acute retinal necrosis: clinical features and outcomes.

Eye (Lond) 2020 Feb 24. Epub 2020 Feb 24.

Department of Ophthalmology, University of British Columbia, 2550 Willow Street, Vancouver, BC, V5Z 3N9, Canada.

Background/objectives: The aim of this study was to identify risk factors, prognosis, and management in patients with concomitant herpetic keratitis and acute retinal necrosis (ARN).

Subjects/methods: In this retrospective observational series, ARN patients in the Greater Vancouver area from 2004 to 2018 were identified through key words, billing codes, and dispensing data from medical records of affiliate researchers and the pharmacy at Vancouver General Hospital.

Results: Twenty-eight patients were diagnosed with ARN during this period. Read More

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http://dx.doi.org/10.1038/s41433-020-0826-zDOI Listing
February 2020

Changes in Etiology of Uveitis in a Single Center in Japan.

Ocul Immunol Inflamm 2020 Feb 18:1-6. Epub 2020 Feb 18.

Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.

: We investigated the changes in etiology of uveitis at the Uveitis Clinic of Tokyo Medical University Hospital in recent years.: Medical records of patients with uveitis diagnosed between 2011 and 2017 (Group A) and between 2001 and 2007 (Group B) were reviewed.: 1,587 patients in group A and 1,507 patients in group B were analyzed. Read More

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http://dx.doi.org/10.1080/09273948.2019.1709649DOI Listing
February 2020

Analysis of inflammatory mediators in the vitreous humor of eyes with pan-uveitis according to aetiological classification.

Sci Rep 2020 Feb 17;10(1):2783. Epub 2020 Feb 17.

Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Treatment of uveitis is complicated because of its multiple aetiologies and elevation of various inflammatory mediators. To determine the mediators that are elevated in the vitreous humor according to the aetiology of the uveitis, we examined the concentrations of 21 inflammatory cytokines, 7 chemokines, and 5 colony-stimulating/growth factors in vitreous samples from 57 eyes with uveitis associated with intraocular lymphoma (IOL, n = 13), sarcoidosis (n = 15), acute retinal necrosis (ARN, n = 13), or bacterial endophthalmitis (BE, n = 16). Samples from eyes with idiopathic epiretinal membrane (n = 15), which is not associated with uveitis, were examined as controls. Read More

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http://dx.doi.org/10.1038/s41598-020-59666-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026072PMC
February 2020

Sequential optical coherence tomography images of early acute retinal necrosis.

Indian J Ophthalmol 2020 03;68(3):520-522

Department of Vitreo.Retina, Giridhar Eye Institute, Ponneth Temple Road, Kadavanthra, Cochin, Kerala, India.

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http://dx.doi.org/10.4103/ijo.IJO_255_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043164PMC

Modulation of Post-Traumatic Immune Response Using the IL-1 Receptor Antagonist Anakinra for Improved Visual Outcomes.

J Neurotrauma 2020 Jun 16;37(12):1463-1480. Epub 2020 Mar 16.

Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA.

The purpose of this study was to characterize acute changes in inflammatory pathways in the mouse eye after blast-mediated traumatic brain injury (bTBI) and to determine whether modulation of these pathways could protect the structure and function of retinal ganglion cells (RGC). The bTBI was induced in C57BL/6J male mice by exposure to three 20 psi blast waves directed toward the head with the body shielded, with an inter-blast interval of one hour. Acute cytokine expression in retinal tissue was measured through reverse transcription-quantitative polymerase chain reaction (RT-qPCR) four hours post-blast. Read More

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http://dx.doi.org/10.1089/neu.2019.6725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249480PMC

Integrin CD11b Deficiency Aggravates Retinal Microglial Activation and RGCs Degeneration After Acute Optic Nerve Injury.

Neurochem Res 2020 May 12;45(5):1072-1085. Epub 2020 Feb 12.

Department of Ophthalmology, Research Institute of Surgery & Daping Hospital, Army Medical Center of PLA, Army Medical University, Chongqing, 400042, People's Republic of China.

Neuroinflammation plays a vital role in the process of a variety of retinal ganglion cells (RGCs) degenerative diseases including traumatic optic neuropathy (TON). Retinal microglial activation is believed as a harbinger of TON, and robust microglial activation can aggravate trauma-induced RGCs degeneration, which ultimately leads to RGCs loss. Toll like receptor 4 (TLR4)-triggered inflammation is of great importance in retinal inflammatory response after optic nerve injury. Read More

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http://dx.doi.org/10.1007/s11064-020-02984-6DOI Listing

Branch Retinal Artery Occlusion as a presenting sign of Acute Retinal Necrosis: a rare association.

J Ophthalmic Inflamm Infect 2020 Feb 12;10(1). Epub 2020 Feb 12.

Vitreo-retina Department, Dr Shroff's Charity Eye Hospital, 5072, Kedarnath Road, Daryaganj, New Delhi, 110002, India.

Background: Acute retinal necrosis (ARN) is a potentially blinding necrotizing viral retinitis. It starts with one or more foci and spreads circumferentially and involves the posterior pole in the later stages. Vascular occlusions such as branch retinal artery occlusion, central retinal artery occlusion, and central retinal vein occlusion may occur secondary to underlying infectious etiology such as ARN. Read More

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http://dx.doi.org/10.1186/s12348-020-0199-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016156PMC
February 2020

Acute changes in the retina and central retinal artery with methamphetamine.

Exp Eye Res 2020 Apr 7;193:107964. Epub 2020 Feb 7.

Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA, 71103, USA. Electronic address:

Methamphetamine (METH), an addictive stimulant of neurotransmitters, is associated with cardiovascular and neurological diseases. METH-induced ophthalmic complications are also present but have been insufficiently investigated. The purpose of this study is to investigate the retinal effects of METH. Read More

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http://dx.doi.org/10.1016/j.exer.2020.107964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113125PMC

MULTIMODAL IMAGING IN ACUTE RETINAL NECROSIS PRESENTING WITH MACULAR INVOLVEMENT.

Retin Cases Brief Rep 2020 Feb 6. Epub 2020 Feb 6.

Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.

Purpose: To report an unusual case of early macular necrosis in acute retinal necrosis and its features on multimodal imaging.

Methods: Findings on fundus examination, laboratory workup, fluorescein angiography, autofluorescence, optical coherence tomography, and optical coherence tomography angiography.

Results: A 31-year-old healthy woman presented with 1 week of photophobia and central scotoma of the right eye. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000978DOI Listing
February 2020

Retinal vascular inflammatory and occlusive changes in infectious and non-infectious uveitis.

Jpn J Ophthalmol 2020 Mar 3;64(2):150-159. Epub 2020 Feb 3.

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.

Purpose: Retinal vasculitis and occlusive changes are important signs of posterior uveitis and are possible diagnostic markers for uveitis. However, the frequency of arteritis and phlebitis in various uveitis entities, including infectious uveitis (IU) and non-infectious uveitis (NIU), have not been systematically investigated.

Study Design: Retrospective. Read More

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http://dx.doi.org/10.1007/s10384-020-00717-4DOI Listing

ENDOGENOUS ASPERGILLUS ENDOPHTHALMITIS IN AN IMMUNOCOMPETENT PATIENT WITH A REMOTE HISTORY OF PULMONARY TUBERCULOSIS.

Retin Cases Brief Rep 2020 Jan 29. Epub 2020 Jan 29.

University of Southern California Roski Eye Institute, Los Angeles, California.

Purpose: To report a case of Aspergillus fumigatus endogenous endophthalmitis in an immunocompetent patient initially diagnosed as acute retinal necrosis.

Methods: Case report.

Patient: A 67-year-old woman with a remote history of treated pulmonary tuberculosis and no ocular history presented to an outside retina specialist with a sudden onset of floaters and blurred vision in one eye. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000910DOI Listing
January 2020

Methamphetamine causes acute toxicity in the retina of Balb/c mice.

Cutan Ocul Toxicol 2020 Jun 7;39(2):83-88. Epub 2020 Feb 7.

Department of Neurology, The First People's Hospital of Yibin, Yibin, People's Republic of China.

As a powerful psychostimulant with high potential for abuse, methamphetamine (Meth) could cause neurological diseases. METH-induced ophthalmic complications are present, but its underlying mechanism has not been completely elucidated, specifically on the retina. This study was to investigate effects of Meth treatment on the retina. Read More

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http://dx.doi.org/10.1080/15569527.2020.1722153DOI Listing

Congenital Toxoplasmosis Presenting as Eosinophilic Encephalomyelitis With Spinal Cord Hemorrhage.

Pediatrics 2020 02 15;145(2). Epub 2020 Jan 15.

Children's Healthcare of Atlanta, Atlanta, Georgia;

A 4-week-old male neonate with a history of intermittent hypothermia in the newborn nursery presented with an acute onset of bilateral lower extremity paralysis and areflexia. Extensive workup demonstrated eosinophilic encephalomyelitis and multifocal hemorrhages of the brain and spinal cord. Funduscopic examination revealed bilateral chorioretinitis with macular scarring. Read More

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http://dx.doi.org/10.1542/peds.2019-1425DOI Listing
February 2020

Multimodal imaging patterns of posterior syphilitic uveitis: a review of the literature, laboratory evaluation and treatment.

Int Ophthalmol 2020 May 11;40(5):1319-1329. Epub 2020 Jan 11.

Eye Institute, Cleveland Clinic Abu Dhabi, Al Maryah Island, PO Box 112412, Abu Dhabi, UAE.

Purpose: To review the multimodal imaging patterns of posterior syphilitic uveitis.

Methods: A systematic review.

Results: The percentage of syphilis has started to increase again: The World Health Organization has reported 12 million new cases of syphilis each year. Read More

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http://dx.doi.org/10.1007/s10792-020-01285-9DOI Listing

A Case of Disseminated Zoster in an Immunocompetent Patient.

Cureus 2019 Dec 4;11(12):e6286. Epub 2019 Dec 4.

Emergency Medicine, Envision Physician Services, Orlando, USA.

The incidence of herpes zoster, more commonly known as shingles, is approximately 1.2 million individuals per year, which has been increasing worldwide. While the most common presentation of zoster is a rash and acute neuritis (the pain associated with the rash) within one or more contiguous dermatomes, other more serious manifestations such as herpes zoster ophthalmicus, acute retinal necrosis, Ramsay Hunt syndrome (herpes zoster oticus), aseptic meningitis, pneumonitis, bacterial superinfection and disseminated zoster ought to be considered by the clinician. Read More

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http://dx.doi.org/10.7759/cureus.6286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939971PMC
December 2019

Update on the Management of Acute Retinal Necrosis.

Ophthalmic Surg Lasers Imaging Retina 2019 12;50(12):748-751

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http://dx.doi.org/10.3928/23258160-20191119-01DOI Listing
December 2019

Recurrent Herpes Gladiatorum: Should we be Screening Our Service Members Prior to Close Combat Training?

Mil Med 2019 Dec 21. Epub 2019 Dec 21.

Department of Dermatology, US Naval Hospital, PSC 482 BOX 1600 FPO, Okinawa, AP 96362-1600.

A 19-year-old active duty Marine presented to clinic with a history of a reoccurring vesicular rash on left side of his forehead. The lesion was cultured and identified as herpes simplex virus 1 (HSV-1). Herpes gladiatorum is a recurrent cutaneous infection caused by HSV-1 and spread by skin-to-skin contact. Read More

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http://dx.doi.org/10.1093/milmed/usz317DOI Listing
December 2019

Varicella zoster virus (VZV) oculomeningoencephalomyeloradiculitis: a previously undescribed constellation.

J Neurovirol 2019 Dec 19. Epub 2019 Dec 19.

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Gates 3W, Philadelphia, PA, 19104, USA.

A 53-year-old immunocompromised woman developed acute left eye blindness and paraparesis suspected to be due to neuromyelitis optica (NMO). During treatment for NMO, right eye blindness and progressive multiple cranial neuropathies developed. Cerebrospinal fluid polymerase chain reaction (PCR) revealed Varicella zoster virus (VZV). Read More

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http://dx.doi.org/10.1007/s13365-019-00820-4DOI Listing
December 2019

Acute retinal necrosis by herpes simplex virus type 1: an unusual presentation of a primary infection.

BMJ Case Rep 2019 Dec 2;12(12). Epub 2019 Dec 2.

Infectious Diseases, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.

Herpes simplex virus (HSV) can affect the central nervous system causing meningitis, encephalitis and, rarely, acute retinal necrosis. We present a case of a 46-year-old man, previously healthy complaining of a 5-day persistent headache and sudden loss of vision of his left eye that progressed to the right. We started ceftriaxone, methylprednisolone and acyclovir for suspected encephalitis with vasculitis. Read More

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http://dx.doi.org/10.1136/bcr-2019-232566DOI Listing
December 2019

Effect of Inhibition of Colony-Stimulating Factor 1 Receptor on Choroidal Neovascularization in Mice.

Am J Pathol 2020 02 26;190(2):412-425. Epub 2019 Nov 26.

Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern; and the Department for BioMedical Research, University of Bern, Bern, Switzerland. Electronic address:

Neovascular age-related macular degeneration is one of the leading causes of blindness. Microglia and macrophages play a critical role in choroidal neovascularization (CNV) and may, therefore, be potential targets to modulate the disease course. This study evaluated the effect of the colony-stimulating factor-1 receptor inhibitor PLX5622 on experimental laser-induced CNV. Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.10.011DOI Listing
February 2020

Complications of herpes zoster in children.

Pediatr Int 2019 Dec 9;61(12):1216-1220. Epub 2019 Dec 9.

Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan.

Background: Herpes zoster (HZ) may cause complications; however, information regarding complications of HZ in children is relatively sparse. We reviewed cases of HZ in children retrospectively and investigated the risk factors contributing to the development of complications.

Methods: A retrospective observational study was conducted at a tertiary care children's hospital in Japan. Read More

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http://dx.doi.org/10.1111/ped.14025DOI Listing
December 2019

Neonatal bilateral acute retinal necrosis in a neonate with a history of severe intrauterine growth restriction.

J AAPOS 2019 12 8;23(6):346-348. Epub 2019 Oct 8.

Department of Infectious Diseases, Universidad Pontifica Bolivariana, Medellín, Colombia.

We present the case of a baby girl born at term with severe intrauterine growth restriction (IUGR) to a gravida 1 mother who was previously healthy and HIV negative. The newborn was evaluated by an ophthalmologist because of her history of IUGR and was diagnosed with intraretinal hemorrhages associated with areas of peripheral retinal necrosis at the posterior pole of both eyes. A diagnosis of acute retinal necrosis of presumed viral origin due to cytomegalovirus virus was considered, and the infant was started on and responded well to valganciclovir. Read More

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http://dx.doi.org/10.1016/j.jaapos.2019.07.007DOI Listing
December 2019

Human encephalitis complicated with bilateral acute retinal necrosis associated with pseudorabies virus infection: A case report.

Int J Infect Dis 2019 Dec 25;89:51-54. Epub 2019 Sep 25.

Department of Ophthalmology, Qilu Hospital of Shandong University, Shandong University, 107 West Wenhua Road, Lixia District, Jinan, Shandong 250012, PR China. Electronic address:

We report the case of a patient who presented with viral encephalitis and a pulmonary infection complicated with bilateral acute retinal necrosis after direct contact with diseased swine. Next-generation sequencing of the cerebrospinal fluid and vitreous humor detected pseudorabies virus (PRV) simultaneously. Intravenous acyclovir and dexamethasone treatment improved the symptoms of encephalitis, and vitrectomy surgery with silicone oil tamponade was used to treat the retinal detachment. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.09.019DOI Listing
December 2019
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Ultra-wide-field fundus imaging of acute retinal necrosis: clinical characteristics and visual significance.

Eye (Lond) 2020 May 25;34(5):864-872. Epub 2019 Sep 25.

Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.

Objectives: To investigate the clinical characteristics of acute retinal necrosis (ARN) with ultra-wide-field imaging (UWFI) and analyse their visual significance.

Methods: Clinical and UWFI records of patients diagnosed with ARN at a single centre over 2 years were reviewed.

Results: In 38 eyes of 35 patients, the clinical manifestations of ARN on UWFI included patchy (12 eyes) or fan-shaped necrotic lesions (26 eyes), retinal arterial obliteration (38 eyes), vitritis (38 eyes), retinal venous haemorrhage (19 eyes), and vitreous haemorrhage (6 eyes). Read More

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http://dx.doi.org/10.1038/s41433-019-0587-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182555PMC
May 2020
1 Read

Fulminant bilateral acute retinal necrosis complicated with secondary herpes simplex type-1 viral encephalitis: A case report.

Medicine (Baltimore) 2019 Aug;98(35):e17001

Department of Neurology.

Rationale: Acute retinal necrosis (ARN), which is characterized by peripheral necrotizing retinitis, severe retinal arteritis, and progressive inflammatory reaction in the vitreous and anterior chambers, has been reported in cases with herpes simplex encephalitis (HSE). It is a relatively rare complication secondary to HSE. However, cases presented with viral encephalitis following ARN were seldom reported. Read More

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http://dx.doi.org/10.1097/MD.0000000000017001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736140PMC
August 2019
4 Reads

Glaucoma After Corneal Trauma or Surgery-A Rapid, Inflammatory, IOP-Independent Pathway.

Cornea 2019 Dec;38(12):1589-1594

Cornea Service, Glaucoma Service and Boston Keratoprosthesis Laboratory, Massachusetts Eye and Ear and Schepens Eye Research Institute, Harvard Medical School, Boston, MA.

Purpose: To review clinical aspects and cellular and molecular steps in the development of long-term glaucoma after corneal surgery or acute trauma-especially the pivotal role of tumor necrosis factor alpha (TNF-α), the rapidity of the secondary damage to the retinal ganglion cells, and the clinical promise of early antiinflammatory intervention.

Methods: A series of laboratory studies on post-injury and post-surgery glaucoma have been compared to clinical outcome studies on the subject, focusing particularly on the vulnerability of the retinal ganglion cells. Alkali burn to the cornea of mice and rabbits served as the main experimental model. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830965PMC
December 2019
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Acute Retinal Necrosis: Virological Features Using Quantitative Polymerase Chain Reaction, Therapeutic Management, and Clinical Outcomes.

Am J Ophthalmol 2019 12 23;208:376-386. Epub 2019 Aug 23.

University of Lyon, Lyon, France; Laboratory of Virology, Institut des Agents Infectieux (IAI) de Lyon, Hospices Civils de Lyon, Lyon, France; Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, Centre National de la Recherche Scientifique (CNRS) UMR5308, Ecole Nationale Supérieure de Lyon (ENS), Equipe Virpath, Lyon, France.

Purpose: To evaluate outcomes of patients treated with intensive intravitreal therapy and to describe the evolution of quantitative real-time polymerase chain reaction (qPCR) in patients treated for acute retinal necrosis (ARN) syndrome.

Design: Retrospective observational case series.

Methods: This study included 25 eyes of 24 patients with ARN who were treated and followed up in 2 departments of ophthalmology in Lyon, France. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.08.007DOI Listing
December 2019
3 Reads

Infectious uveitis in immunodeficient HIV-negative patients: A retrospective study.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2019 Aug 21. Epub 2019 Aug 21.

Department of Ophthalmology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.

Aims: Cases of infectious uveitis in immunodeficient patients may present with atypical clinical features because the clinical course of disease is usually affected by the compromised immune system. Therefore, it is sometimes difficult to determine the correct diagnosis. The aim of this study was to evaluate a prevalence of immunodeficient HIV-negative individuals among patients with infectious uveitis and to assess diagnostic and therapeutic approaches. Read More

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http://dx.doi.org/10.5507/bp.2019.036DOI Listing
August 2019
3 Reads

Development of Acute Retinal Necrosis in a Patient with Ocular Sarcoidosis: A Case Report.

Ocul Immunol Inflamm 2019 15;27(7):1067-1070. Epub 2019 Aug 15.

Department of Ophthalmology, National Defense Medical College , Tokorozawa , Japan.

: To report a case of acute retinal necrosis (ARN) caused by varicella-zoster virus (VZV) in an elderly patient with ocular sarcoidosis after oral corticosteroid indication. : Retrospective case report. : A 75-year-old male with a past history of ocular sarcoidosis came with blurred left vision. Read More

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https://www.tandfonline.com/doi/full/10.1080/09273948.2019.1
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http://dx.doi.org/10.1080/09273948.2019.1635168DOI Listing
April 2020
8 Reads

Postoperative Cataract Endophthalmitis Masquerading as Hemorrhagic Occlusive Retinal Vasculitis (HORV): A Case Report.

Ocul Immunol Inflamm 2019 Aug 15:1-4. Epub 2019 Aug 15.

a Department of Ophthalmology and Visual Neurosciences, University of Minnesota , Minneapolis , USA.

: To report a case of postoperative cataract bacterial endophthalmitis masquerading as hemorrhagic occlusive retinal vasculitis (HORV). : A 69-year-old female presents following uncomplicated cataract surgery of her right eye with new onset floaters, aching pain, decreased visual acuity, increased intraocular pressure, deep anterior chamber reaction, vitritis, and retinal vascular sheathing with diffuse blot hemorrhages. The majority of these clinical symptoms are commonly seen in bacterial endophthalmitis with exception to the retinal findings, which point to possible diagnosis of HORV, a recently described, largely untreatable phenomena associated with intracameral vancomycin use during surgery. Read More

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http://dx.doi.org/10.1080/09273948.2019.1634216DOI Listing
August 2019
2 Reads

Human Adenovirus: An Unusual Causative Agent for Acute Retinal Necrosis Presented with Central Retinal Vascular Occlusion.

Ocul Immunol Inflamm 2019 Aug 14:1-5. Epub 2019 Aug 14.

a Ulucanlar Eye Training and Research Hospital, University of Health Sciences , Ankara , Turkey.

We describe a case of acute retinal necrosis (ARN) with central retinal vascular occlusion caused by human adenovirus (HAdV). A 41-year-old man presented with a sudden decrease of visual acuity in his right eye since seven days. Visual acuity was hand movements and ophthalmic examination of the right eye revealed diffuse hemorrhagic retinal vasculitis with panuveitis. Read More

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http://dx.doi.org/10.1080/09273948.2019.1624780DOI Listing
August 2019
4 Reads

Acute Retinal Necrosis: Is The Current Valacyclovir Regimen Adequate?

Ocul Immunol Inflamm 2020 May 12;28(4):665-666. Epub 2019 Aug 12.

Department of Ophthalmology and Visual Sciences, Federal University of São Paulo , São Paulo, Brazil.

Acute Retinal Necrosis (ARN) is a potentially devastating form of Uveitis. Antivirals are the mainstay treatment for this syndrome. In this letter, we question the current oral Valacyclovir dosage, based on the experience we had with a recent unresponsive ARN case. Read More

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http://dx.doi.org/10.1080/09273948.2019.1616771DOI Listing
May 2020
1 Read

Acute retinal necrosis secondary to Varicella Zoster Virus.

IDCases 2019 12;18:e00585. Epub 2019 Jul 12.

Division of Cardiology, Department of Medicine, University of Missouri, One Hospital Drive, Columbia, MO, 65212, United States.

A 54 year old female presented to the ophthalmology clinic with pain and decreased vision in her left eye. No past medical history other than primary varicella zoster infection, in her childhood. The eye exam revealed a macular region with scattered areas of retinal opacity along with patches of necrosis on the periphery. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630083PMC
July 2019
8 Reads

Atypical herpes simplex virus type 2 acute retinal necrosis presentation with large subretinal lesion.

Am J Ophthalmol Case Rep 2019 Sep 20;15:100501. Epub 2019 Jun 20.

Department of Ophthalmology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, IL, USA.

Purpose: To report the unique clinical findings of a case of Herpes Simplex Virus Type 2 herpetic retinitis manifesting as a large elevated subretinal lesion.

Observations: A 26-year-old Hispanic male with no significant past medical history presented with a one-week history of right eye pain and endorsement of worsening vision. Ophthalmic examination of the right eye identified a markedly elevated white subretinal lesion with associated findings of vitritis and hypotony. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24519936183049
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http://dx.doi.org/10.1016/j.ajoc.2019.100501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599871PMC
September 2019
3 Reads

Atypical posterior pole retinitis.

Am J Ophthalmol Case Rep 2019 Sep 13;15:100494. Epub 2019 Jun 13.

Sankara Nethralaya, Chennai, India.

Purpose: Necrotizing retinopathy is an uncommon, devastating, potentially blinding condition, which can be seen in both immunocompetent and immunocompromised patients. The purpose of this case is to report a new subset of necrotizing viral retinopathy.

Observation: A 34-year old lady presented to our outpatient department with sudden diminution of vision in both eyes following a brief history of viral fever with vesicular rashes. Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.100494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582377PMC
September 2019
6 Reads

Alpha herpes virus type and viral load in intraocular fluids in patients with acute retinal necrosis.

BMJ Open Ophthalmol 2019 9;4(1):e000247. Epub 2019 Apr 9.

Department of Clinical Neuroscience, University of Gothenburg, Mölndal, Sweden.

Objectives: To identify all patients tested positive for herpes viruses in intraocular samples between 2007 and 2016 in South-Western Sweden and evaluate which of these met the criteria of acute retinal necrosis (ARN). To compare viral load in intraocular samples and virus type with clinical outcome.

Method And Analysis: Retrospective case series. Read More

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http://dx.doi.org/10.1136/bmjophth-2018-000247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528764PMC
April 2019
10 Reads

Risk of Rhegmatogenous Retinal Detachment in Acute Retinal Necrosis With and Without Prophylactic Intervention.

Am J Ophthalmol 2019 10 3;206:140-148. Epub 2019 Jun 3.

Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:

Purpose: To study whether preventive laser or preventive vitrectomy is able to lower the risk of rhegmatogenous retinal detachment (RRD) in patients with acute retinal necrosis (ARN).

Design: A retrospective, interventional case series.

Methods: We performed a retrospective study of 59 patients (63 eyes) with ARN treated in a single tertiary referral center. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.05.023DOI Listing
October 2019
10 Reads

Epac1 and Glycyrrhizin Both Inhibit HMGB1 Levels to Reduce Diabetes-Induced Neuronal and Vascular Damage in the Mouse Retina.

J Clin Med 2019 May 31;8(6). Epub 2019 May 31.

Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI 48201, USA.

The role of high mobility group box 1 (HMGB1) in acute diabetic retinal damage has been demonstrated. We recently reported that glycyrrhizin, a HMGB1 inhibitor, protected the diabetic retina against neuronal, vascular, and permeability changes. In this study, we wanted to investigate the role of exchange protein for cAMP 1 (Epac1) on HMGB1 and the actions of glycyrrhizin. Read More

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http://dx.doi.org/10.3390/jcm8060772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616522PMC
May 2019
2 Reads