1,058 results match your criteria Acute Retinal Necrosis


Viral retinitis: diagnosis and management in the era of biologic immunosuppression - a review.

Clin Exp Ophthalmol 2019 Mar 12. Epub 2019 Mar 12.

Moorfields Eye Hospital, London, UK.

Necrotising retinitis is a rare ocular infection that historically led to high rates of visual morbidity. While acute retinal retinal necrosis occurs in immunocompetent patients, the majority of cases are associated with immunocompromise such as in cytomegalovirus retinitis and progressive outer retinal necrosis. This review summarises the clinical and diagnostic features, management, and outcomes of herpetic retinitis. Read More

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http://doi.wiley.com/10.1111/ceo.13500
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http://dx.doi.org/10.1111/ceo.13500DOI Listing
March 2019
9 Reads

Varicella-zoster virus as a causative agent of acute retinal necrosis in younger patients.

Chin Med J (Engl) 2019 Mar;132(6):659-663

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.

Background: Herpes virus is considered to be the pathogen of acute retinal necrosis (ARN) infection. Previous studies have found that patients with ARN caused by the varicella-zoster virus (VZV) are often older, and patients with herpes simplex virus (HSV) induced ARN are considerably younger. However, in our clinical work, we find that VZV is also a pathogen in younger ARN patients. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416020PMC
March 2019
2 Reads

Concurrent acute retinal necrosis and orbital inflammation: Report of 2 cases.

Am J Ophthalmol Case Rep 2019 Jun 13;14:47-50. Epub 2019 Feb 13.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.

Purpose: To describe the rare entity of concurrent herpetic acute retinal necrosis (ARN) and orbital inflammation.

Observations: Two cases of ARN with simultaneous orbital inflammation are described. A 40-year old male presented with a painful left eye and hand motion visual acuity (VA). Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393694PMC
June 2019
1 Read

Vagal Nerve Stimulation Attenuates Ischemia-Reperfusion Induced Retina Dysfunction in Acute Ocular Hypertension.

Front Neurosci 2019 11;13:87. Epub 2019 Feb 11.

Eye Center, Renmin Hospital of Wuhan University, Wuhan, China.

The present study aimed to investigate whether cervical vagal nerve stimulation (VNS) could prevent retinal ganglion cell (RGC) loss and retinal dysfunction after ischemia/reperfusion (I/R) injury. First, rats were randomly divided into sham group ( = 4) and VNS group ( = 12). Activation of the nodose ganglia (NOG), nucleus of the solitary tract (NTS), superior salivatory nucleus (SSN), and pterygopalatine ganglion (PPG) neural circuit were evaluated by c-fos expression at 0 h after sham VNS and at 0 h ( = 4), 6 h ( = 4), 72 h ( = 4) after VNS. Read More

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http://dx.doi.org/10.3389/fnins.2019.00087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378858PMC
February 2019
2 Reads

Subretinal Hypopyon in Presumed Tubercular Uveitis: A Report of Two Cases.

Middle East Afr J Ophthalmol 2018 Jul-Dec;25(3-4):163-166

Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Subretinal hypopyon is an uncommon entity which has been described in ocular infections and inflammations including endophthalmitis, acute retinal necrosis, and sympathetic ophthalmia. The authors report subretinal hypopyon in two cases of presumed tubercular uveitis which responded well to antitubercular therapy (ATT). The first case was a 47-year-old male with bilateral peripapillary chorioretinitis with a subretinal hypopyon. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_187_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348936PMC

[Diagnostic Strategy and Therapeutic Dilemma in Acute Posterior and Panuveitis].

Klin Monbl Augenheilkd 2019 Apr 14;236(4):487-491. Epub 2019 Feb 14.

Augenklinik, Universitätsspital Basel, Schweiz.

Acute posterior and panuveitis mostly affect younger patients and affect both eyes in more than half of cases. Because of the severe consequences in the clinical course, rapid and broad differential diagnosis are critical steps. Permanent loss of vision after a delay in starting therapy and the initiation of ineffective treatment are both serious risks. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0828-7395
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http://dx.doi.org/10.1055/a-0828-7395DOI Listing
April 2019
6 Reads

Invasive aspergillosis manifesting as retinal necrosis in a patient treated with ruxolitinib.

Arch Soc Esp Oftalmol 2019 Jan 31. Epub 2019 Jan 31.

Sección de Retina Médica, Departamento de Oftalmología, Hospital Universitario Virgen del Rocío, Sevilla, España.

A 30 year-old man with acute myeloblastic leukaemia and secondary myelodysplastic syndrome developed graft-versus-host disease. The patient was treated with ruxolitinib. After being treated for 3 months with ruxolitinib, an inhibitor of Janus kinase, he developed Aspergillus retinal necrosis resistant to common treatment. Read More

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http://dx.doi.org/10.1016/j.oftal.2018.12.006DOI Listing
January 2019
1 Read

Acute Posterior Multifocal Placoid Pigment Epitheliopathy Complicated by Fatal Cerebral Vasculitis.

J Neuroophthalmol 2019 Jan 22. Epub 2019 Jan 22.

Departments of Ophthalmology and Visual Sciences (RNM, GPVS, RR, GJH) and Neurology (LS), Washington University School of Medicine in St. Louis, St. Louis, Missouri; Blue Sky Neurology (NHK), Denver, Colorado; Department of Pathology and Immunology (CJF, RES, SD, GJH), Washington University School of Medicine, St. Louis, Missouri; Department of Radiology (JT), University of Colorado Anschutz Medical Campus, Aurora, Colorado; and Department of Neurology (AD), Brigham and Women's Hospital, Boston, Massachusetts.

A 21-year-old man experienced unilateral vision loss associated with multiple atrophic chorioretinal lesions. He was treated for a presumptive diagnosis of acute retinal necrosis, but his vision did not improve with antiviral therapy. Over the course of several weeks, his symptoms progressed to involve both eyes. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000750DOI Listing
January 2019
13 Reads

A Novel Synthetic Steroid of 2β,3α,5α-Trihydroxy-androst-6-one Alleviates the Loss of Rat Retinal Ganglion Cells Caused by Acute Intraocular Hypertension via Inhibiting the Inflammatory Activation of Microglia.

Molecules 2019 Jan 11;24(2). Epub 2019 Jan 11.

Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

Neuroinflammation has been well recognized as a key pathological event in acute glaucoma. The medical therapy of acute glaucoma mainly focuses on lowering intraocular pressure (IOP), while there are still scarce anti-inflammatory agents in the clinical treatment of acute glaucoma. Here we reported that β,3α,5α-trihydroxy-androst-6-one (sterone), a novel synthetic polyhydric steroid, blocked neuroinflammation mediated by microglia/macrophages and alleviated the loss of retinal ganglion cells (RGCs) caused by acute intraocular hypertension (AIH). Read More

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http://dx.doi.org/10.3390/molecules24020252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358879PMC
January 2019
2.416 Impact Factor

NECROSIS OF THE RETINA AND UVEAL TRACT SECONDARY TO EXPANDING GAS TAMPONADE.

Retin Cases Brief Rep 2018 Dec 27. Epub 2018 Dec 27.

Retina Specialists of Alabama, Birmingham, Alabama.

Purpose: To present a case of retinal and uveal necrosis caused by expanding gas tamponade after pars plana vitrectomy.

Methods: Single case report.

Results: An otherwise healthy 66-year-old woman underwent pars plana vitrectomy with intended 20% sulfur hexafluoride (SF6) tamponade for macular hole repair of her pseudophakic left eye. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000841DOI Listing
December 2018
2 Reads

RETINAL FINDINGS IN PRESUMED INFECTIOUS POSTERIOR UVEITIS AND CORRELATION WITH POLYMERASE CHAIN REACTION RESULTS.

Retina 2018 Dec 27. Epub 2018 Dec 27.

Department of Ophthalmology, the Icahn School of Medicine at Mount Sinai, New York, New York.

Purpose: To correlate demographics, retinal lesion characteristics, and host immune status with the pathogen found on polymerase chain reaction analysis of aqueous fluid in patients with suspected infectious posterior uveitis.

Methods: Medical records of patients who underwent anterior chamber paracentesis for suspected infectious posterior uveitis and had retinal photographs between 2014 and 2016 at a single institution were reviewed. Data collection included demographics, clinical appearance of the lesions, and polymerase chain reaction results. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002423DOI Listing
December 2018
3 Reads

A derivative of betulinic acid protects human Retinal Pigment Epithelial (RPE) cells from cobalt chloride-induced acute hypoxic stress.

Exp Eye Res 2019 03 19;180:92-101. Epub 2018 Dec 19.

School of Pharmacy, The University of Sydney, NSW, 2006, Australia. Electronic address:

The Retinal Pigment Epithelium (RPE) is a monolayer of cells located above the choroid. It mediates human visual cycle and nourishes photoreceptors. Hypoxia-induced oxidative stress to RPE is a vital cause of retinal degeneration such as the Age-related Macular Degeneration. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144835183067
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http://dx.doi.org/10.1016/j.exer.2018.12.011DOI Listing
March 2019
20 Reads

Acute retinal necrosis (ARN) following chickenpox in a patient of Vogt-Koyanagi-Harada (VKH) syndrome using immunosuppressants.

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Smt. Kanuri Santhamma Centre for Vitreo Retinal Diseases, LV Prasad Eye Institute, Hyderabad, India.

A 36-year-old woman presented with diminution of vision and floaters in both the eyes. Both eyes had disc oedema, multiple pockets of neurosensory detachments along with vitritis. Fluorescein angiography and optical coherence tomography showed characteristic features of Vogt-Koyanagi-Harada (VKH) syndrome (figure 1). Read More

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http://dx.doi.org/10.1136/bcr-2018-227290DOI Listing
November 2018

Vitrectomy with Silicone Oil Tamponade in Rhegmatogenous Retinal Detachment following Acute Retinal Necrosis: Clinical Outcomes and Prognostic Factors.

Semin Ophthalmol 2018 Nov 29:1-5. Epub 2018 Nov 29.

a Smt. Kanuri Santhamma Center for Vitreoretinal diseases, LV Prasad Eye Institute , Hyderabad , India.

Purpose: The purpose of the study is to report the prognostic factors and outcomes of vitrectomy (PPV) with silicone oil tamponade in rhegmatogenous retinal detachment (RRD) secondary to acute retinal necrosis (ARN).

Methods: This retrospective, non-randomized, interventional comparative study included 38 eyes of 38 patients. All cases underwent PPV with silicone oil tamponade. Read More

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http://dx.doi.org/10.1080/08820538.2018.1551907DOI Listing
November 2018
3 Reads

Multimodal imaging of retinal metastasis masquerading as an acute retinal necrosis.

Int J Retina Vitreous 2018 21;4:43. Epub 2018 Nov 21.

1Suita Tokushukai Hospital Eye Center, 21-1, Senriokanishi, Suita City, Osaka 565-0814 Japan.

Background: To report the multimodal imaging and histology of a case of metastatic esophageal cancer with vitreoretinal involvement resembling acute retinal necrosis (ARN) in a patient receiving systemic chemotherapy.

Case Presentation: A 69-year-old Japanese man with a history of stage 4 esophageal carcinoma, treated with three cycles of 5-fluorouracil (5-FU) and cisplatin (CDDP) chemotherapy as well as 30 sessions of radiation therapy, presented with new onset of blurry vision in the right eye (OD). Visual acuity was 20/200 OD. Read More

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https://journalretinavitreous.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/s40942-018-0149-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249976PMC
November 2018
11 Reads

Progressive, subretinal fibrosis mimicking retinal necrosis with poor visual prognosis in sympathetic ophthalmia: A rare finding.

Indian J Ophthalmol 2018 12;66(12):1877-1879

Department of Uveitis and Ocular Inflammation, Vittala International Institute of Ophthalmology and Prabha Eye Clinic and Research Centre, Bengaluru, Karnataka, India.

We report a rare finding of progressive subretinal fibrosis mimicking retinal necrosis in 2 cases of sympathetic ophthalmia. Histopathology of the inciting eye and vitreous biopsy of the sympathizing eye ruled out infections and masquerades. Progression of inflammation and rapid deterioration of vision inspite of maximum immunosuppression are key findings in this variant of sympathetic ophthalmia. Read More

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http://dx.doi.org/10.4103/ijo.IJO_268_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256904PMC
December 2018
20 Reads

Herpetic Panophthalmitis: A Diagnostic Dilemma.

Ocul Immunol Inflamm 2018 Nov 16:1-3. Epub 2018 Nov 16.

b Ophthalmology , University of Rochester David and Ilene Flaum Eye Institute , Rochester , New York , USA.

Purpose: To describe an uncommon presentation of ocular infection caused by human herpes simplex virus 2 (HSV-2).

Methods: Case report.

Results: A 32-year-old female with no prior history of mucocutaneous herpesvirus infection presented with a minimally painful hypertensive granulomatous panophthalmitis and optic neuropathy that was initially suspected to be orbital cellulitis. Read More

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https://www.tandfonline.com/doi/full/10.1080/09273948.2018.1
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http://dx.doi.org/10.1080/09273948.2018.1546404DOI Listing
November 2018
10 Reads

Bilateral renal cortical necrosis following acute pancreatitis - A rare complication of a common disease.

Saudi J Kidney Dis Transpl 2018 Sep-Oct;29(5):1211-1215

Department of Nephrology, Government T. D. Medical College, Alappuzha, Kerala, India.

Acute renal cortical necrosis is a rare cause of intrinsic acute kidney injury (AKI) which is commonly associated with obstetric complications such as placental abruption and some serious systemic disorders such as hemolytic-uremic syndrome, sepsis, severe burns, and snake bite. Acute pancreatitis is an extremely rare cause of renal cortical necrosis, and only less than 10 cases are reported in the literature. Here, we present a 24-year-old male presented with features of acute pancreatitis and oliguric AKI. Read More

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http://www.sjkdt.org/text.asp?2018/29/5/1211/243968
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http://dx.doi.org/10.4103/1319-2442.243968DOI Listing
November 2018
10 Reads

EPSTEIN-BARR VIRUS ACUTE RETINAL NECROSIS IN AN IMMUNOCOMPETENT HOST.

Retin Cases Brief Rep 2018 Oct 23. Epub 2018 Oct 23.

Department of Ophthalmology, Jewish General Hospital, Montreal, Quebec, Canada.

Purpose: To describe a case of Epstein-Barr virus (EBV)-associated acute retinal necrosis (ARN) in an immunocompetent patient and to summarize the clinical features of published molecularly confirmed EBV-ARN cases.

Methods: Case report and literature review.

Results: An 83-year-old immunocompetent woman with unilateral ARN presented with visual acuity of light perception. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000819DOI Listing
October 2018
3 Reads

Response to anti-VEGF therapy in macular oedema secondary to acute retinal necrosis.

Arch Soc Esp Oftalmol 2019 Jan 15;94(1):41-44. Epub 2018 Oct 15.

Hospital Universitario de Burgos, Burgos, España.

A 55 year-old female patient with unilateral Acute Retinal Necrosis (ARN) developed macular oedema (MO) after the resolution of her necrosis. The macular oedema (MO) was managed and controlled for four years with intravitreal anti-VEGF injections. Anti-VEGF therapy could be useful for the treatment of MO secondary to ARN, the same as for treating MO resulting from panuveitis, where its efficacy has been already demonstrated. Read More

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http://dx.doi.org/10.1016/j.oftal.2018.07.007DOI Listing
January 2019

BILATERAL ACUTE RETINAL NECROSIS: A Case Series.

Retina 2018 Oct 3. Epub 2018 Oct 3.

Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.

Purpose: To investigate the clinical characteristics and visual outcome of bilateral acute retinal necrosis.

Methods: The study included 30 patients (60 eyes) who were diagnosed with bilateral acute retinal necrosis. The medical records were reviewed. Read More

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http://Insights.ovid.com/crossref?an=00006982-900000000-9632
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http://dx.doi.org/10.1097/IAE.0000000000002341DOI Listing
October 2018
1 Read

Acute Retinal Necrosis Presenting With Optic Disc Edema.

J Neuroophthalmol 2019 Mar;39(1):105-106

Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.

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http://dx.doi.org/10.1097/WNO.0000000000000707DOI Listing
March 2019
2 Reads

Acute retinal necrosis in a neonate with HSV II encephalitis.

Pediatr Neonatol 2018 Jun 12. Epub 2018 Jun 12.

Department of Neonatology, Guangdong Women and Children Hospital, Guang Zhou Medical University, Guangzhou, Guangdong, 510010, China. Electronic address:

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http://dx.doi.org/10.1016/j.pedneo.2018.06.001DOI Listing
June 2018
1 Read

Bilateral Acute Retinal Necrosis: Clinical Features and Outcomes in a Multicenter Study.

Ocul Immunol Inflamm 2018 Jul 30:1-9. Epub 2018 Jul 30.

a Department of Ophthalmology , Ospedale San Raffaele Scientific Institute, University Vita-Salute , Milan , Italy.

Purpose: To describe clinical features and outcome in bilateral acute retinal necrosis (BARN).

Methods: Observational retrospective longitudinal review of ocular findings.

Results: Thirty eyes of 15 patients (age 44. Read More

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http://dx.doi.org/10.1080/09273948.2018.1501494DOI Listing
July 2018
4 Reads

Assessing the Precision of ICD-10 Codes for Uveitis in 2 Electronic Health Record Systems.

JAMA Ophthalmol 2018 Oct;136(10):1186-1190

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Importance: Electronic health record (EHR) systems based on International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) coding of disease entities are increasingly being used to generate large data sets for analysis. However, the reproducibility of ICD-10 coding in uveitis has not been assessed across EHR platforms, and imprecision in coding may lead to improper conclusions in big-data analyses.

Objective: To compare ICD-10 coding of uveitis using 2 EHR systems. Read More

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http://archopht.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaophthalmol.2018.3001DOI Listing
October 2018
12 Reads

OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FINDINGS IN ACUTE RETINAL NECROSIS.

Retin Cases Brief Rep 2018 Jul 25. Epub 2018 Jul 25.

Department of Ophthalmology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.

Purpose: To report clinical features of acute retinal necrosis (ARN) using optical coherence tomography angiography.

Methods: A 59-year-old female patient presented with blurred vision in the left eye for 1 day. The patient presented posterior uveitis with multiple peripheral areas of retinal pallor with presumed acute retinal necrosis. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000778DOI Listing
July 2018
2 Reads

ACUTE RETINAL NECROSIS ASSOCIATED WITH HERPES ZOSTER VACCINATION.

Retin Cases Brief Rep 2018 Jul 25. Epub 2018 Jul 25.

Department of Ophthalmology, Sir Charles Gairdner Hospital, Hospital Ave, Western Australia, Australia.

Purpose: To report a case of Zostavax-associated acute retinal necrosis in a patient with chronic lymphocytic leukemia.

Methods: Case report.

Patients: A 76-year-old white man. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000761DOI Listing
July 2018
1 Read

Tumor Necrosis Factor Inhibition in the Acute Management of Traumatic Optic Neuropathy.

Invest Ophthalmol Vis Sci 2018 06;59(7):2905-2912

Department of Ophthalmology, Dr. Nasser Al-Rashid Orbital Vision Research Center, Bascom Palmer Eye Institute, Miami, Florida, United States.

Purpose: To determine the effectiveness of etanercept, a tumor necrosis factor (TNF) inhibitor, in conferring neuroprotection to retinal ganglion cells (RGCs) and improving visual outcomes after optic nerve trauma with either optic nerve crush (ONC) or sonication-induced traumatic optic neuropathy (SI-TON) in mice.

Methods: Mouse optic nerves were unilaterally subjected to ONC (n = 20) or SI-TON (n = 20). TNF expression was evaluated by using immunohistochemistry and quantitative RT-PCR (qRT-PCR) in optic nerves harvested 6 and 24 hours post ONC (n = 10) and SI-TON (n = 10). Read More

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http://dx.doi.org/10.1167/iovs.18-24431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989875PMC
June 2018
13 Reads

Clinical feature and visual prognosis of acute retinal necrosis according to the initially involved zone and extent: 10-year experience.

Eur J Ophthalmol 2019 Mar 12;29(2):244-250. Epub 2018 Jul 12.

2 Department of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.

Purpose:: We aimed to analyze the visual prognosis and clinical characteristics of acute retinal necrosis according to the initially involved zone and extent.

Study Design:: Retrospective, consecutive, cross-sectional study.

Methods:: We retrospectively reviewed acute retinal necrosis patients who were treated with systemic antiviral treatment, and assessed the visual prognosis of acute retinal necrosis following antiviral treatment based on the initially involved zone and the extent of acute retinal necrosis at the time of diagnosis. Read More

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http://journals.sagepub.com/doi/10.1177/1120672118787438
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http://dx.doi.org/10.1177/1120672118787438DOI Listing
March 2019
13 Reads

VZV-associated acute retinal necrosis in a patient with MS treated with natalizumab.

Neurol Neuroimmunol Neuroinflamm 2018 Sep 9;5(5):e475. Epub 2018 Jul 9.

Department of Neurology (M.P., J.T., C.C., D.B.), Otto-von-Guericke University; Department of Ophthalmology (M.W., C.S.), Otto-von-Guericke University, Magdeburg; Charité-Universitätsmedizin Berlin (F.P.), Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, NeuroCure Clinical Research Center; Department of Neurology (F.P.), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; and Experimental and Clinical Research Center (F.P.), Max Delbrueck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039210PMC
September 2018
1 Read

Transcorneal Electrical Stimulation Inhibits Retinal Microglial Activation and Enhances Retinal Ganglion Cell Survival After Acute Ocular Hypertensive Injury.

Transl Vis Sci Technol 2018 May 29;7(3). Epub 2018 May 29.

Department of Ophthalmology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR.

Purpose: To investigate the effect of transcorneal electrical stimulation (TcES) on retinal ganglion cell (RGC) function and survival after acute ocular hypertension-related retinal injury in gerbil eyes.

Methods: Gerbil eyes were subjected to acute ocular hypertensive injury (80 mm Hg for 60 minutes). In the treatment group, TcES was applied to the surgical eye immediately and then twice weekly for a total of 1 month. Read More

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http://dx.doi.org/10.1167/tvst.7.3.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976234PMC
May 2018
6 Reads

Typhae pollen polysaccharides ameliorate diabetic retinal injury in a streptozotocin-induced diabetic rat model.

J Ethnopharmacol 2018 Oct 23;224:169-176. Epub 2018 May 23.

School of Pharmacy, Xi'an Jiaotong University, 76 Yanta West Road, Xi'an 710061, PR China. Electronic address:

Ethnopharmacological Relevance: According to ancient traditional Chinese medicine, Typhae Pollen (TP) is commonly used to treat fundus haemorrhage because it improves blood circulation.

Aims Of The Study: This study evaluated the role of the main TP component, polysaccharides (TPP), on diabetic retinopathy (DR) and its possible mechanisms of inhibiting inflammation and improving blood circulation.

Materials And Methods: After successful establishment of a diabetic rat model, TPP was administered to diabetic rats for treatment, and the rats were sacrificed at 12 weeks. Read More

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http://dx.doi.org/10.1016/j.jep.2018.05.030DOI Listing
October 2018
7 Reads

ZIKA virus infection causes persistent chorioretinal lesions.

Emerg Microbes Infect 2018 May 25;7(1):96. Epub 2018 May 25.

Division of Biotechnology Review and Research-III, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, 20993, USA.

Zika-infected patients can have eye involvement ranging from mild conjunctivitis to severe chorioretinal lesions, however the possible long-term sequelae of infection and timeline to recovery remain unknown. Here we describe the partial recovery of chorioretinal lesions in an immunocompetent patient diagnosed with bilateral posterior uveitis associated with Zika infection and show that some lesions resolved with focal atrophy evident as pigmentary changes on funduscopy. To better understand the progression of the lesions and correlate the changes in fundus imaging with local viral load, immune responses, and retinal damage, we developed a symptomatic mouse model of ocular Zika virus infection. Read More

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http://dx.doi.org/10.1038/s41426-018-0096-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970181PMC
May 2018
5 Reads

Diffusion-Weighted Magnetic Resonance Imaging in Acute Retinal Pathology.

Neuroophthalmology 2018 Jun 13;42(3):191-193. Epub 2017 Oct 13.

Department of Neurology, Case Western Reserve University, Cleveland, Ohio, USA.

The authors describe diffusion-weighted magnetic resonance imaging (DWI) as an accessible way to screen for acute retinal pathology in emergency setting. They describe three proof-of-principle patients who had abrupt onset of vision loss from acute retinal pathology where DWI was diagnostic. The deficits included central retinal artery occlusion and acute retinitis with retinal necrosis. Read More

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http://dx.doi.org/10.1080/01658107.2017.1354385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958964PMC
June 2018
3 Reads

Bilateral acute retinal necrosis associated with bilateral uveal effusion in an immunocompetent patient: A challenging association.

Indian J Ophthalmol 2018 06;66(6):866-868

Department of Uvea and Vitreo Retina, Aravind Eye Hospital, Puducherry, India.

Bilateral uveal effusion syndrome associated with bilateral acute retinal necrosis is a diagnostic and therapeutic challenge. A 52 year old man presented with bilateral angle closure with choroidal detachment. With restricted fundus view, parenteral steroid was started. Read More

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http://www.ijo.in/text.asp?2018/66/6/866/232857
Publisher Site
http://dx.doi.org/10.4103/ijo.IJO_954_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989521PMC
June 2018
9 Reads

[The relationship between optical coherence tomography performance and visual acuity of acute retinal necrosis].

Authors:
Y Di J J Ye D H Li

Zhonghua Yan Ke Za Zhi 2018 May;54(5):369-374

Department of Ophthalmology, Peking Union Medical Academy of Medical Sciences, Beijing 100730, China.

To analyze the relationship between optical coherence tomography(OCT) performance and visual acuity of patients with acute retinal necrosis (ARN). Retrospective analysis was performed on the patients diagnosed with ARN at the ophthalmology department of Peking union hospital during October 2011 and May 2016. Fourteen patients (15 eyes), 9 males and 5 females, whose anterior and posterior inflammation disappeared and the retinal necrosis lesion in the fundus of the eye subsided were included. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2018.05.011DOI Listing
May 2018
3 Reads

[Research progress on the diagnosis and treatment of acute retinal necrosis].

Authors:
Y Di J J Ye

Zhonghua Yan Ke Za Zhi 2018 Apr;54(4):306-311

Department of ophthalmology, Peking Union Medical Academy of Medical Sciences, Beijing 100730, China.

Acute retinal necrosis is an uncommon but devastating and potentially blinding ophthalmopathy featured with unfavorable prognosis as the lesions tend to develop rapidly in a circumferential way in few days. Therefore timely diagnosis and early treatment are of great significance. The polymerase chain reaction test on intraocular fluid can improve specificity and sensitivity of the etiological detection for acute retinal necrosis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2018.04.017DOI Listing
April 2018
2 Reads

Varicella-zoster virus necrotising retinitis, retinal vasculitis and panuveitis following uncomplicated chickenpox in an immunocompetent child.

BMJ Case Rep 2018 Apr 5;2018. Epub 2018 Apr 5.

Manchester Royal Eye Hospital, Manchester, UK.

A 4-year-old girl presented with acute left visual loss 4 weeks after uneventful chickenpox. She was found to have left necrotising retinitis and profound retinal vasculitis and vitritis. Aqueous humour was PCR positive for varicella-zoster virus. Read More

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http://dx.doi.org/10.1136/bcr-2017-223823DOI Listing
April 2018
6 Reads

Progressive outer retinal necrosis after rituximab and cyclophosphamide therapy.

Indian J Ophthalmol 2018 04;66(4):591-593

Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

We report a case of progressive outer retinal necrosis (PORN) in a patient of microscopic polyangitis (MPA), being treated with immunosuppressive drugs such as cyclophosphamide and rituximab. Her aqueous tap was positive for Varicella Zoster virus and she was treated with oral and intravitreal antivirals, along with discontinuation of one of the immunosuppressive agents, i.e. Read More

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http://dx.doi.org/10.4103/ijo.IJO_811_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892074PMC
April 2018
10 Reads
0.930 Impact Factor

Sequential retinal necrosis secondary to varicella zoster in unrecognised long-standing HIV infection: patient safety report.

BMJ Case Rep 2018 Mar 21;2018. Epub 2018 Mar 21.

Department of Genitourinary Medicine, Royal Bolton Hospital NHS Foundation Trust, Bolton, UK.

A retired woman with left ophthalmic shingles of over 2 years' duration attended with bilateral vision loss and systemic upset. Acute retinal necrosis with detachment was detected on right fundus examination. Cataract in left eye precluded funduscopy. Read More

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http://dx.doi.org/10.1136/bcr-2017-222237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878387PMC
March 2018
9 Reads

Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation.

J Neuroinflammation 2018 Mar 16;15(1):85. Epub 2018 Mar 16.

Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France.

Background: The retinal pigment epithelium (RPE) is a monolayer of pigmented cells with important barrier and immuno-suppressive functions in the eye. We have previously shown that acute stimulation of RPE cells by tumor necrosis factor alpha (TNFα) downregulates the expression of OTX2 (Orthodenticle homeobox 2) and dependent RPE genes. We here investigated the long-term effects of TNFα on RPE cell morphology and key functions in vitro. Read More

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http://dx.doi.org/10.1186/s12974-018-1106-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857126PMC
March 2018
22 Reads

ACUTE RETINAL NECROSIS AND CONTRALATERAL CUTANEOUS ERUPTION AFTER THE SHINGLES VACCINE.

Retin Cases Brief Rep 2018 Mar 8. Epub 2018 Mar 8.

Department of Ophthalmology, New York Medical College.

Purpose: To the best of our knowledge, we present a rare case report describing an occurrence of acute retinal necrosis in an otherwise healthy individual who received the shingles vaccine.

Methods: Observational case report.

Patient: A 63-year-old healthy and immunocompetent white man presented with change of vision in the left eye after blunt trauma. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000729DOI Listing
March 2018
2 Reads

Bilateral central retinal artery occlusion as presenting manifestation of human immunodeficiency virus infection.

Indian J Ophthalmol 2018 Mar;66(3):466-468

Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

A 30-year-old male with bilateral acute visual loss presented with retinal edema in the posterior pole and peripapillary region with extensive retinal hemorrhages. Fluorescein angiography revealed delayed arterial filling in the right eye and absent arterial filling in the left eye, suggesting bilateral central retinal artery occlusion. Systemic evaluation revealed a history of chronic low-grade fever and generalized lymphadenopathy. Read More

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http://dx.doi.org/10.4103/ijo.IJO_906_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859616PMC
March 2018
8 Reads
0.930 Impact Factor

Cytokine Signaling Protein 3 Deficiency in Myeloid Cells Promotes Retinal Degeneration and Angiogenesis through Arginase-1 Up-Regulation in Experimental Autoimmune Uveoretinitis.

Am J Pathol 2018 04 13;188(4):1007-1020. Epub 2018 Feb 13.

Centre for Experimental Medicine, School of Medicine, Dentistry & Biomedical Science, Queen's University Belfast, Belfast, United Kingdom. Electronic address:

The suppressor of cytokine signaling protein 3 (SOCS3) critically controls immune cell activation, although its role in macrophage polarization and function remains controversial. Using experimental autoimmune uveoretinitis (EAU) as a model, we show that inflammation-mediated retinal degeneration is exaggerated and retinal angiogenesis is accelerated in mice with SOCS3 deficiency in myeloid cells (LysMSOCS3). At the acute stage of EAU, the population of infiltrating neutrophils was increased and the population of macrophages decreased in LysMSOCS3 mice compared with that in wild-type (WT) mice. Read More

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http://dx.doi.org/10.1016/j.ajpath.2017.12.021DOI Listing
April 2018
7 Reads

Necrotizing retinitis of multifactorial etiology.

Rom J Ophthalmol 2017 Jan-Mar;61(1):49-53

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

We present the case of a 73-year-old woman with osteoporosis, who presented to the emergency room with a sudden vision loss and ocular pain in the right eye, which appeared two days before. The patient mentioned loss of appetite, weight loss for three months and low fever for two weeks. Among the ophthalmological findings, the most important were panuveitis, and large confluent necrotic areas in the peripheral retina. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710053PMC
May 2018
14 Reads

Comparing Treatment of Acute Retinal Necrosis With Either Oral Valacyclovir or Intravenous Acyclovir.

Am J Ophthalmol 2018 04 12;188:173-180. Epub 2018 Feb 12.

Moorfields Eye Hospital, London, United Kingdom; UCL Institute of Ophthalmology, London, United Kingdom; Technion - Israel Institute of Technology, Bnai Zion Medical Center, Haifa, Israel. Electronic address:

Purpose: To compare the visual outcomes of patients with acute retinal necrosis (ARN) treated initially with intravenous acyclovir vs oral valacyclovir therapy.

Design: Retrospective, comparative, interventional case series.

Methods: Sixty-two patients (68 eyes) with ARN, treated at Moorfields Eye Hospital (United Kingdom) between 1992 and 2016, were identified through the hospital's electronic database. Read More

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http://dx.doi.org/10.1016/j.ajo.2018.02.001DOI Listing
April 2018
8 Reads

Risk Factors for Development of Rhegmatogenous Retinal Detachment in Patients with Uveitis.

Ocul Immunol Inflamm 2018 Feb 8:1-5. Epub 2018 Feb 8.

b Department of Ophthalmology , Erasmus Medical Center , Rotterdam , The Netherlands.

Purpose: To describe risk factors for development of rhegmatogenous retinal detachment (RRD) in patients with uveitis.

Methods: We performed a retrospective review of 411 consecutive human immunodeficiency virus-negative patients with uveitis (571 affected eyes) and report on prevalence, risk factors and visual outcomes of patients with RRD.

Results: Prevalence of RRD was 7% of all patients with uveitis. Read More

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http://dx.doi.org/10.1080/09273948.2018.1424343DOI Listing
February 2018
10 Reads

Real-time polymerase chain reaction in acute retinal necrosis following encephalitis.

Indian J Ophthalmol 2018 Feb;66(2):322-324

Uveitis Service, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Acute retinal necrosis (ARN) following herpes simplex encephalitis (HSE) in an immunocompetent patient is a rare condition. Quantitative real-time polymerase chain reaction (qPCR) has made it possible to identify and quantify viral genome. We report a case of ARN following HSE managed with the help of qPCR. Read More

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http://dx.doi.org/10.4103/ijo.IJO_748_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819131PMC
February 2018
4 Reads

The necessity and optimal time for performing pars plana vitrectomy in acute retinal necrosis patients.

BMC Ophthalmol 2018 Jan 22;18(1):15. Epub 2018 Jan 22.

Ophthalmology Department, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Background: To compare the efficacy of pars plana vitrectomy (PPV) at different time points to treat acute retinal necrosis (ARN) and to investigate the necessity of PPV for ARN.

Methods: A retrospective review of the treatment options and outcomes of the ARN patients was performed. Thirty ARN patients (34 eyes) were included in this study. Read More

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http://dx.doi.org/10.1186/s12886-018-0674-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778764PMC
January 2018
3 Reads

Effect of sex steroid hormone fluctuations in the pathophysiology of male-retinal pigment epithelial cells.

J Cell Physiol 2018 Sep 25;233(9):6965-6974. Epub 2018 Mar 25.

Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania.

Gender-based differences may influence the occurrence of several ocular conditions suggesting the possibility that fluctuations in sex steroid homeostasis may have direct effects on the eye physiology. Here, we evaluated the effect of sex steroid hormone fluctuations in male retinal pigment epithelial cells, RPEs (ARPE-19). To mimic hormonal fluctuations occurring during aging, we exposed ARPE-19 to acute, prolonged or chronic estradiol, and progesterone challenges. Read More

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http://dx.doi.org/10.1002/jcp.26486DOI Listing
September 2018
12 Reads