28,237 results match your criteria Acute Respiratory Distress Syndrome


Laparoscopy First Approach in Acute Care Surgery.

Med Princ Pract 2019 Apr 16. Epub 2019 Apr 16.

Introduction: The use of laparoscopic management as a first choice for the treatment of duodenal perforation is gaining ground but is not routine in many centers. In this report we aim to report our experience with laparoscopy as the first approach for the repair of duodenal perforation.

Materials And Methods: This is a retrospective review of patients during our initial experience with the use of laparoscopy for the treatment of duodenal perforation between 2009 and 2013. Read More

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http://dx.doi.org/10.1159/000500107DOI Listing
April 2019
1 Read

A consensus redefinition of transfusion-related acute lung injury.

Transfusion 2019 Apr 16. Epub 2019 Apr 16.

Department of Pathology, University British Columbia, Vancouver, British Columbia, Canada.

Background: Transfusion-related acute lung injury (TRALI) is a serious complication of blood transfusion and is among the leading causes of transfusion-related morbidity and mortality in most developed countries. In the past decade, the pathophysiology of this potentially life-threatening syndrome has been increasingly elucidated, large cohort studies have identified associated patient conditions and transfusion risk factors, and preventive strategies have been successfully implemented. These new insights provide a rationale for updating the 2004 consensus definition of TRALI. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/trf.15311
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http://dx.doi.org/10.1111/trf.15311DOI Listing
April 2019
1 Read

Dysautonomia and hyponatraemia as harbingers of Guillain-Barre syndrome.

BMJ Case Rep 2019 Apr 15;12(4). Epub 2019 Apr 15.

Department of Critical Care, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India.

A 56-year-old woman with a medical history of hypertension presented to our hospital with back pain, abdominal pain, vomiting and elevated blood pressure. The laboratory parameters including evaluation for secondary hypertension were within normal ranges at the time of presentation. During her hospitalisation, fluctuations in her blood pressure and pulse were observed which were attributed to autonomic disturbances, the cause of which was unknown. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22692
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http://dx.doi.org/10.1136/bcr-2018-226925DOI Listing
April 2019
1 Read

Heterogeneity of regional inflection points from pressure-volume curves assessed by electrical impedance tomography.

Crit Care 2019 Apr 16;23(1):119. Epub 2019 Apr 16.

Department of Morphology, Surgery and Experimental Medicine, Intensive Care Unit, University of Ferrara, Azienda Ospedaliera - Universitaria Sant'Anna Hospital, Via Aldo Moro, Ferrara, Italy.

Background: The pressure-volume (P-V) curve has been suggested as a bedside tool to set mechanical ventilation; however, it reflects a global behavior of the lung without giving information on the regional mechanical properties. Regional P-V (PVr) curves derived from electrical impedance tomography (EIT) could provide valuable clinical information at bedside, being able to explore the regional mechanics of the lung. In the present study, we hypothesized that regional P-V curves would provide different information from those obtained from global P-V curves, both in terms of upper and lower inflection points. Read More

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http://dx.doi.org/10.1186/s13054-019-2417-6DOI Listing

Alveolar Macrophage Transcriptional Programs are Associated with Outcomes in Acute Respiratory Distress Syndrome.

Am J Respir Crit Care Med 2019 Apr 16. Epub 2019 Apr 16.

University of Washington, Division of Pulmonary, Critical Care, and Sleep Medicine, Seattle, Washington, United States.

Rationale: Serial measurements of alveolar macrophage (AM) transcriptional changes in patients with acute respiratory distress syndrome (ARDS) could identify cell-specific biologic programs that are associated with clinical outcomes.

Objectives: Determine whether AM transcriptional programs are associated with prolonged mechanical ventilation and 28-day mortality in subjects with ARDS.

Methods: We performed genome-wide transcriptional profiling of AMs purified from bronchoalveolar lavage fluid collected from 35 patients with ARDS. Read More

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http://dx.doi.org/10.1164/rccm.201807-1381OCDOI Listing

Noninvasive Ventilation-Facilitated Bronchofiberoscopy in Patients with Respiratory Failure.

Adv Exp Med Biol 2019 Apr 16. Epub 2019 Apr 16.

Department of Pneumology, School of Medicine in Katowice, Upper-Silesian Medical Center, Medical University of Silesia, Katowice, Poland.

Respiratory failure is one of the most important risk factors for diagnostic bronchofiberoscopy (BF), whereas therapeutic bronchoscopies are typically performed in intubated patients. Only a few published studies analyzed the outcomes of noninvasive mechanical ventilation (NIV)-facilitated BF. In this case series, we present our experiences with NIV-facilitated diagnostic and therapeutic BF performed in patients with respiratory failure that was associated with acute interstitial pulmonary disease, chronic obstructive pulmonary disease, cystic fibrosis exacerbation, foreign body aspiration, tracheal stenosis, pneumonia, and in a patient with a neuromuscular disease. Read More

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http://dx.doi.org/10.1007/5584_2019_375DOI Listing

[52-year-old female with community-acquired pneumonia, acute respiratory distress syndrome : Preparation for the medical specialist examination: Part 25].

Authors:
A Güldner P Spieth

Anaesthesist 2019 Apr;68(Suppl 2):194-198

Klinik für Anästhesiologie und Intensivtherapie, Universitätsklinikum Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.

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http://dx.doi.org/10.1007/s00101-019-0580-4DOI Listing

Noninvasive ventilation in acute hypoxic respiratory failure in medical intensive care unit: A study in rural medical college.

Int J Crit Illn Inj Sci 2019 Jan-Mar;9(1):36-42

Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India.

Introduction: Noninvasive ventilation (NIV) has emerged as an important tool for the management of acute hypoxic respiratory failure (AHRF) and has been the area of research in the last two decades. In this study, we have tried to find out the outcome of NIV in patients with AHRF.

Materials And Methods: In this prospective, observational study, all the patients of AHRF requiring NIV were enrolled, and heart rate (HR), respiratory rate (RR), arterial blood gas parameters, and NIV settings at baseline, 1 h, and 4 h were collected. Read More

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http://dx.doi.org/10.4103/IJCIIS.IJCIIS_40_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423923PMC

Usefulness of ultrasound in the management of acute respiratory distress syndrome.

Int J Crit Illn Inj Sci 2019 Jan-Mar;9(1):11-15

Department of Critical Care, King Hamad University Hospital, Al Muharaq, Kingdom of Bahrain.

Acute respiratory distress syndrome (ARDS) is a life-threatening disease. Different imaging techniques have been used to diagnose and guide the ventilatory management of patients with ARDS. Chest ultrasound is a reliable tool to identify interstitial syndrome, lung consolidation, lung collapse, and pleural effusion. Read More

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http://www.ijciis.org/text.asp?2019/9/1/11/253758
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http://dx.doi.org/10.4103/IJCIIS.IJCIIS_30_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423925PMC
April 2019
1 Read

Rhinovirus-induced Rapidly Progressing Acute Respiratory Distress Syndrome in an Immunocompetent Host.

Cureus 2019 Feb 1;11(2):e3997. Epub 2019 Feb 1.

Internal Medicine, Staten Island University Hospital, Staten Island, USA.

A previously healthy, 59-year-old female presented with respiratory distress and dry cough for one week. Outpatient radiographic findings were suspicious for basilar pneumonia. Empiric broad-spectrum antibiotics were started; however, she continued to deteriorate rapidly over the next 48 hours, with chest X-ray showing diffuse bilateral multifocal airspace opacities consistent with acute respiratory distress syndrome. Read More

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http://dx.doi.org/10.7759/cureus.3997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443533PMC
February 2019

Lung injury prediction scores: Clinical validation and C-reactive protein involvement in high risk patients.

Med Intensiva 2019 Apr 13. Epub 2019 Apr 13.

Critical Care Medicine Department, Cairo University, Cairo, Egypt. Electronic address:

Objective: A study was made to validate two previously derived lung injury prediction scores (LIPS) for the prediction of acute respiratory distress syndrome (ARDS) in high risk intensive care patients, with the incorporation of C-reactive protein (CRP) for improving score accuracy.

Design: A prospective, observational cohort study was carried out.

Patients: A total of 200 patients with APACHE II score ≥15 and at least one ARDS risk factor upon ICU admission were included. Read More

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http://dx.doi.org/10.1016/j.medin.2019.02.010DOI Listing

EphA2 antagonism alleviates LPS-induced acute lung injury via Nrf2/HO-1, TLR4/MyD88 and RhoA/ROCK pathways.

Int Immunopharmacol 2019 Apr 12;72:176-185. Epub 2019 Apr 12.

Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China. Electronic address:

Eph receptor tyrosine kinases have a wide range of biological functions and have gradually been recognized increasingly as key regulators of inflammation and injury diseases. Although previous studies suggested that EphA2 receptor may be involved in the regulation of inflammation and vascular permeability in injured lung, the detailed effects of EphA2 on LPS-induced acute lung injury (ALI) are still inadequate and the underlying mechanism remains poorly understood. In this study, we detected the effects of EphA2 antagonism on inflammation, pulmonary vascular permeability and oxidative stress in LPS-induced ALI and investigate the potential mechanism. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.008DOI Listing

Non-ST elevation myocardial infarction induced by carbon monoxide poisoning: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15151

Department of Cardiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing.

Rationale: Acute myocardial infarction is a rare complication of carbon monoxide poisoning. there is often no chest pain and other typical manifestations. We report a patient with mild carbon monoxide poisoning who had acute dyspnea as the earliest symptom and was later diagnosed with non-ST elevation myocardial infarction (NSTEMI) and acute left heart failure. Read More

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http://Insights.ovid.com/crossref?an=00005792-201904120-0005
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http://dx.doi.org/10.1097/MD.0000000000015151DOI Listing
April 2019
3 Reads

Novel Risk Factors for Posttraumatic Stress Disorder Symptoms in Family Members of Acute Respiratory Distress Syndrome Survivors.

Crit Care Med 2019 Apr 15. Epub 2019 Apr 15.

Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA.

Objectives: Family members of ICU survivors report long-term psychologic symptoms of posttraumatic stress disorder. We describe patient- and family-member risk factors for posttraumatic stress disorder symptoms among family members of survivors of acute respiratory distress syndrome.

Design: Prospective cohort study of family members of acute respiratory distress syndrome survivors. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003774DOI Listing

Improvement in Oxygenation Utilizing Transpulmonary Pressure Monitoring for Optimal Positive End-Expiratory Pressure in Pediatric Acute Respiratory Distress Syndrome: A Case Report.

A A Pract 2019 Apr 8. Epub 2019 Apr 8.

Anesthesiology and Perioperative Medicine.

In severe pediatric acute respiratory distress syndrome, data are lacking on methods to measure and set optimal positive end-expiratory pressure. We present a 2-year-old girl with Trisomy 21 who developed severe pediatric acute respiratory distress syndrome and refractory hypoxemia from human metapneumovirus pneumonia. Esophageal manometry was utilized to measure transpulmonary pressure, and positive end-expiratory pressure was increased to 19 cm H2O, resulting in rapid improvement in oxygenation. Read More

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http://dx.doi.org/10.1213/XAA.0000000000001008DOI Listing

Veno-venous extracorporeal membrane oxygenation for patient with a history of open cholecystectomy and acute respiratory distress syndrome caused by coinfection of avian influenza A (H7N9) and Epstein-Barr virus.

Chin Med J (Engl) 2019 Apr 9. Epub 2019 Apr 9.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China.

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http://dx.doi.org/10.1097/CM9.0000000000000254DOI Listing

Extracellular Matrix Component Remodeling in Respiratory Diseases: What Has Been Found in Clinical and Experimental Studies?

Cells 2019 Apr 11;8(4). Epub 2019 Apr 11.

Department of Clinical Medicine, Laboratory of Experimental Therapeutics/LIM-20, School of Medicine of University of Sao Paulo, Sao Paulo 01246-903, Brazil.

Changes in extracellular matrix (ECM) components in the lungs are associated with the progression of respiratory diseases, such as asthma, chronic obstructive pulmonary disease (COPD), and acute respiratory distress syndrome (ARDS). Experimental and clinical studies have revealed that structural changes in ECM components occur under chronic inflammatory conditions, and these changes are associated with impaired lung function. In bronchial asthma, elastic and collagen fiber remodeling, mostly in the airway walls, is associated with an increase in mucus secretion, leading to airway hyperreactivity. Read More

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https://www.mdpi.com/2073-4409/8/4/342
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http://dx.doi.org/10.3390/cells8040342DOI Listing
April 2019
4 Reads

Recreational 'mud fever': induced diffuse alveolar hemorrhage and severe acute respiratory distress syndrome in a U.S. Navy seaman following 'mud-run' in Hawaii.

IDCases 2019 23;15:e00529. Epub 2019 Mar 23.

University of Maryland School of Medicine, Baltimore, MD, United States.

A 23-year-old man with a viral-like prodrome developed sudden severe dyspnea and was found to have renal failure, anemia, shock, and diffuse alveolar hemorrhage with acute respiratory distress syndrome, requiring emergent endotracheal intubation and extracorporeal membrane oxygenation (ECMO). Travel and exposure history from peripheral sources revealed that the patient had participated in a 'mud-run' in Hawaii two weeks prior to symptom onset. The patient was subsequently diagnosed with leptospirosis and treated with ceftriaxone and doxycycline. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441746PMC
March 2019
3 Reads

Delayed retroperitoneal hemorrhage during veno-venous extracorporeal membrane oxygenation: a case report.

Acute Med Surg 2019 Apr 10;6(2):180-184. Epub 2019 Jan 10.

Department of Emergency Medicine Sapporo Medical University Sapporo Hokkaido Japan.

Case: There are several reports of retroperitoneal hemorrhage induced by percutaneous femoral cannulation for extracorporeal membrane oxygenation (ECMO). However, there are no reports of delayed retroperitoneal hemorrhage, which develops a few days after ECMO initiation and is unrelated to the ECMO cannulation. Herein, we report a rare case of delayed retroperitoneal hemorrhage during veno-venous extracorporeal membrane oxygenation (VV-ECMO). Read More

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http://dx.doi.org/10.1002/ams2.385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442533PMC
April 2019
1 Read

pH-Responsive Nanoparticles Targeted to Lungs for Improved Therapy of Acute Lung Inflammation/Injury.

ACS Appl Mater Interfaces 2019 Apr 11. Epub 2019 Apr 11.

Dysregulated vascular inflammation is the underlying of acute lung inflammation/injury (ALI). Bacterial infections and trauma cause ALI that may rapidly lead to acute respiratory distress syndrome (ARDS). There are no pharmacological therapies available to patients with ALI/ARDS, partially as drugs cannot specifically target the lungs. Read More

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http://dx.doi.org/10.1021/acsami.9b04051DOI Listing
April 2019
1 Read

Dynamic multi-outcome prediction after injury: Applying adaptive machine learning for precision medicine in trauma.

PLoS One 2019 10;14(4):e0213836. Epub 2019 Apr 10.

Denver Health Medical Center and the University of Colorado; Denver, Colorado, United States of America.

Objective: Machine learning techniques have demonstrated superior discrimination compared to conventional statistical approaches in predicting trauma death. The objective of this study is to evaluate whether machine learning algorithms can be used to assess risk and dynamically identify patient-specific modifiable factors critical to patient trajectory for multiple key outcomes after severe injury.

Methods: SuperLearner, an ensemble machine-learning algorithm, was applied to prospective observational cohort data from 1494 critically-injured patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213836PLOS
April 2019
2 Reads

Mesenchymal stem cells may ameliorate inflammation in an ex vivo model of extracorporeal membrane oxygenation.

Perfusion 2019 Apr;34(1_suppl):15-21

1 Critical Care Research Group, The Prince Charles Hospital, The University of Queensland, Brisbane, QLD, Australia.

Introduction: Mesenchymal stem cells exhibit immunomodulatory properties which are currently being investigated as a novel treatment option for Acute Respiratory Distress Syndrome. However, the feasibility and efficacy of mesenchymal stem cell therapy in the setting of extracorporeal membrane oxygenation is poorly understood. This study aimed to characterise markers of innate immune activation in response to mesenchymal stem cells during an ex vivo simulation of extracorporeal membrane oxygenation. Read More

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http://dx.doi.org/10.1177/0267659119830857DOI Listing
April 2019
1 Read

Hemoglobin trigger and approach to red blood cell transfusions during veno-venous extracorporeal membrane oxygenation: the international TRAIN-ECMO survey.

Perfusion 2019 Apr;34(1_suppl):39-48

1 Department of Anesthesia and Intensive Care, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), Palermo, Italy.

Introduction: Optimal red blood cell transfusion practice during veno-venous extracorporeal membrane oxygenation (VV ECMO) is still under debate. This survey aimed to assess the Hb trigger (also comparing with other critically ill patients) and major physiologic determinants considered for transfusions during veno-venous extracorporeal membrane oxygenation.

Methods: Voluntary Web-based survey, endorsed by the European Society of Intensive Care Medicine, conducted among VV ECMO pratictioners worldwide. Read More

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http://dx.doi.org/10.1177/0267659119830526DOI Listing
April 2019
1 Read
1.083 Impact Factor

Long-term pulmonary function and quality of life in adults after extracorporeal membrane oxygenation for respiratory failure.

Perfusion 2019 Apr;34(1_suppl):49-57

2 Department of Pediatric Anaesthesia, Intensive Care and ECMO Services, Astrid Lindgren Children's Hospital, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

Background: There is a significant long-term burden on survivors after acute respiratory distress syndrome, even 5 years after discharge. This is not well investigated in patients treated with extracorporeal membrane oxygenation. The objective of this study was to describe very-long-term (⩾3 years) disability in lung function and morphology, quality of life, mood disorders, walking capacity, and return to work status in extracorporeal membrane oxygenation survivors. Read More

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http://dx.doi.org/10.1177/0267659119830244DOI Listing

Sequelae of Acute Respiratory Distress Syndrome: Interest of Rehabilitation.

Case Rep Crit Care 2019 6;2019:7953141. Epub 2019 Mar 6.

Normandie Université, UNIROUEN, EA 3832: Centre d'Etudes des Transformations par les Activités Physiques et Sportives, Institut de Recherche Interdisciplinaire Homme et Société, 76130 Mont-Saint-Aignan, France.

Case Presentation: This clinical case presents the history of a woman hospitalized for acute respiratory distress syndrome (ARDS). A 62-year-old woman, with regular physical activity and no history of respiratory disease or smoking, was hospitalized for moderate ARDS with bilateral pneumonitis. Fourteen days later, she was discharged from the intensive care unit and received respiratory physical therapy. Read More

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http://dx.doi.org/10.1155/2019/7953141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431389PMC
March 2019
1 Read

Heterogeneous effects of alveolar recruitment in acute respiratory distress syndrome: a machine learning reanalysis of the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial.

Br J Anaesth 2019 Apr 5. Epub 2019 Apr 5.

Research Institute, HCor-Hospital do Coração, São Paulo, Brazil.

Background: Despite a robust physiological rationale, recruitment manoeuvres with PEEP titration were associated with harm in the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial (ART). We sought to investigate the potential heterogeneity in treatment effects in patients enrolled in the ART, using a machine learning approach.

Methods: The primary outcome was hospital mortality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00070912193018
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http://dx.doi.org/10.1016/j.bja.2019.02.026DOI Listing
April 2019
3 Reads

Scrub typhus infection, not a benign disease: an experience from a tertiary care center in Northern India.

Med Pharm Rep 2019 Jan 15;92(1):36-42. Epub 2019 Jan 15.

Internal Medicine Department, Pt. BD Sharma PGIMS, Rohtak, India.

Introduction: Scrub typhus is an acute febrile illness caused by . It is characterised by fever, rash, myalgia and diffuse lymphadenopathy. Most common complications are sepsis, shock, acute respiratory distress syndrome (ARDS), hepatitis, pre renal azotemia and multi organ dysfunction syndrome (MODS). Read More

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http://dx.doi.org/10.15386/cjmed-1088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448495PMC
January 2019
1 Read

Prophylactic pre-esophagogastroduodenoscopy tracheal intubation in patients with upper gastrointestinal bleeding.

Proc (Bayl Univ Med Cent) 2019 Jan 15;32(1):22-25. Epub 2019 Jan 15.

Department of Internal Medicine, Texas Tech University Health Sciences CenterLubbockTexas.

The indications for endotracheal intubation (ETI) during an esophagogastroduodenoscopy (EGD) procedure remain unclear. This study performed a descriptive analysis of patients who underwent prophylactic tracheal intubation during or before an EGD to prevent pulmonary aspiration. We selected patients with an upper gastrointestinal bleed in an intensive care unit who underwent EGD between 2000 and 2013. Read More

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http://dx.doi.org/10.1080/08998280.2018.1530007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442910PMC
January 2019
2 Reads

The effect of emergency department crowding on lung-protective ventilation utilization for critically ill patients.

J Crit Care 2019 Mar 23;52:40-47. Epub 2019 Mar 23.

Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address:

Objective: To measure effects of ED crowding on lung-protective ventilation (LPV) utilization in critically ill ED patients.

Methods: This is a retrospective cohort study of adult mechanically ventilated ED patients admitted to the medical intensive care unit (MICU), over a 3.5-year period at a single academic tertiary care hospital. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.03.008DOI Listing
March 2019
1 Read

Axin-1 binds to Caveolin-1 to regulate the LPS-induced inflammatory response in AT-I cells.

Biochem Biophys Res Commun 2019 Apr 3. Epub 2019 Apr 3.

Guangdong Provincial Key Laboratory of Proteomics and State Key Laboratory of Organ Failure Research, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address:

Caveolin-1 has been reported to play an important role in the pathogenesis of acute respiratory distress syndrome (ARDS). This study was designed to identify Caveolin-1-interacting proteins to reveal the molecular mechanisms of ARDS. Yeast two-hybrid screening was performed using Caveolin-1 as the bait, and Axin-1 was identified as a binding partner for Caveolin-1. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.153DOI Listing
April 2019
1 Read

A study on the protective effects of CpG oligodeoxynucleotide-induced mucosal immunity against lung injury in a mouse acute respiratory distress syndrome model.

J Cell Physiol 2019 Apr 5. Epub 2019 Apr 5.

Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

This study aims to determine the feasibility of using oligodeoxynucleotides with unmethylated cytosine-guanine dinucleotide sequences (CpG ODN) as an immunity protection strategy for a mouse model of acute respiratory distress syndrome (ARDS). This is a prospective laboratory animal investigation. Twenty-week-old BALB/c mice in Animal research laboratory were randomized into groups. Read More

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http://dx.doi.org/10.1002/jcp.28613DOI Listing
April 2019
3 Reads
3.839 Impact Factor

Effects of different corticosteroid doses and durations on smoke inhalation-induced acute lung injury and pulmonary fibrosis in the rat.

Int Immunopharmacol 2019 Apr 2;71:392-403. Epub 2019 Apr 2.

Department of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital & Postgraduate Medical School, 100039 Beijing, China. Electronic address:

Excessive inflammation induced by cytokine storm and coagulation disorders is considered the primary characteristic of smoke inhalation-induced acute lung injury (SI-ALI). Glucocorticoids such as methylprednisolone (MP) are commonly used to treat patients with inflammatory diseases; however, the management of ALI or acute respiratory distress syndrome (ARDS) remains controversial. We explored the effects of different MP doses and durations in a rat SI-ALI model. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.051DOI Listing
April 2019
4 Reads
2.472 Impact Factor

A CRTH2 antagonist, CT-133, suppresses NF-κB signalling to relieve lipopolysaccharide-induced acute lung injury.

Eur J Pharmacol 2019 Apr 3;854:79-91. Epub 2019 Apr 3.

Department of Critical Care Medicine and Orthopedics, The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou City, 310009, China. Electronic address:

Acute lung injury (ALI) and acute respiratory distress syndrome are life-threatening conditions that still have no definite pharmacotherapy. Hence, we investigate the potential effectiveness and underlying mechanism of CT-133, a newly developed selective antagonist of prostaglandin D2 receptor 2 (DP2) or of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2), against lipopolysaccharide (LPS)-induced ALI. CT-133 (10 or 30 mg/kg) or dexamethasone (1 mg/kg, positive control) were intragastrically administered 1 h before and 12 h after intratracheal LPS instillation, and primary neutrophils and macrophages and RAW264. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.03.053DOI Listing
April 2019
1 Read

Airway pressure release ventilation during acute hypoxemic respiratory failure: a systematic review and meta-analysis of randomized controlled trials.

Ann Intensive Care 2019 Apr 4;9(1):44. Epub 2019 Apr 4.

Anesthesia and Intensive Care Unit, Università Politecnica delle Marche, Ancona, Italy.

Background: Airway pressure release ventilation (APRV) has been considered a tempting mode of ventilation during acute respiratory failure within the concept of open lung ventilation. We performed a systematic review and meta-analysis to verify whether adult patients with hypoxemic respiratory failure have a higher number of ventilator-free days at day 28 when ventilated in APRV compared to conventional ventilation strategy. Secondary outcomes were difference in PaO/FiO at day 3, ICU length of stay (LOS), ICU and hospital mortality, mean arterial pressure (MAP), risk of barotrauma and level of sedation. Read More

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http://dx.doi.org/10.1186/s13613-019-0518-7DOI Listing
April 2019
4 Reads

Influence of Preoperative Oropharyngeal Microflora on the Occurrence of Postoperative Pneumonia and Survival in Patients Undergoing Esophagectomy for Esophageal Cancer.

Ann Surg 2019 Mar 28. Epub 2019 Mar 28.

Department of Gastroenterological Surgery, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.

MINI: We investigated the influence of the preoperative oropharyngeal microflora on the outcomes of patients undergoing esophagectomy for esophageal cancer. The existence of allopatric antibiotic-resistant flora was an independent predictor of postoperative pneumonia. In addition, the long-term survival of patients with such microbes in their oropharynx was significantly worse than those without. Read More

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http://dx.doi.org/10.1097/SLA.0000000000003287DOI Listing
March 2019
4 Reads
8.327 Impact Factor

Early corticosteroid treatment for postoperative acute lung injury after lung cancer surgery.

Ther Adv Respir Dis 2019 Jan-Dec;13:1753466619840256

Division of Pulmonary and Critical Care Medicine, Department of Medicine and Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, South Korea.

Background: Acute lung injury (ALI) is the most serious pulmonary complication after lung resection. Although the beneficial effects of low-dose corticosteroids have been demonstrated in patients with postoperative ALI, there are limited data on optimal corticosteroid treatment.

Methods: We retrospectively analyzed 58 patients who were diagnosed with ALI among 7593 patients who underwent lung cancer surgery between January 2009 and December 2016. Read More

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http://dx.doi.org/10.1177/1753466619840256DOI Listing
April 2019
1 Read

Using selective lung injury to improve murine models of spatially heterogeneous lung diseases.

PLoS One 2019 3;14(4):e0202456. Epub 2019 Apr 3.

Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

Many lung diseases, such as the acute respiratory distress syndrome (ARDS), display significant regional heterogeneity with patches of severely injured tissue adjacent to apparently healthy tissue. Current mouse models that aim to mimic ARDS generally produce diffuse injuries that cannot reproducibly generate ARDS's regional heterogeneity. This deficiency prevents the evaluation of how well therapeutic agents reach the most injured regions and precludes many regenerative medicine studies since it is not possible to know which apparently healing regions suffered severe injury initially. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202456PLOS
April 2019
4 Reads

Tidal Volume Ventilation Strategy in ICU Patients Without ARDS-Reply.

JAMA 2019 04;321(13):1312-1313

Mahidol Oxford Tropical Medicine Research Unit (MORU), Mahidol University, Bangkok, Thailand.

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http://dx.doi.org/10.1001/jama.2019.0306DOI Listing
April 2019
4 Reads

Tidal Volume Ventilation Strategy in ICU Patients Without ARDS.

JAMA 2019 04;321(13):1311-1312

Department of Anesthesiology, Pain and Palliative Care, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1001/jama.2019.0298DOI Listing
April 2019
2 Reads

Associated Broncho-Pulmonary Infection After Immunotherapy: A Case Report and A Smart-phone Based Video of Trophozoite

Turkiye Parazitol Derg 2019 Mar;43(1):44-46

Ege Üniversitesi Tıp Fakültesi, Tıbbi Parazitoloji Anabilim Dalı, İzmir, Türkiye

The frequency of bronchopulmonary protozoan infections has raised due to increased number of immunosuppressed patients in recent years. One of them is which is a multi-flagellated protozoan parasite of termites and several cockroach species. The drug regimens commonly used in bronchopulmonary infections are not effective against . Read More

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http://dx.doi.org/10.4274/tpd.galenos.2018.6031DOI Listing
March 2019
1 Read

A phase I/II trial of weekly nab-paclitaxel for pretreated non-small-cell lung cancer patients without epidermal growth factor receptor mutations and anaplastic lymphoma kinase rearrangement.

Asia Pac J Clin Oncol 2019 Apr 1. Epub 2019 Apr 1.

Department of Respiratory Medicine, Okayama University Hospital, Okayama, Japan.

Aim: We investigated the efficacy, safety and optimal schedule of nanoparticle albumin-bound paclitaxel monotherapy as second- or third-line treatment for non-small-cell lung cancer patients without epidermal growth factor receptor mutation and anaplastic lymphoma kinase rearrangement.

Methods: Patients with pretreated advanced non-small-cell lung cancer without epidermal growth factor receptor mutation and anaplastic lymphoma kinase rearrangement were included. The patients were administered 100 mg/m of nanoparticle albumin-bound paclitaxel on days 1, 8, 15 and 22 (level 0) or on days 1, 8 and 15 (level -1) every 4 weeks during phase I of the trial. Read More

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http://dx.doi.org/10.1111/ajco.13147DOI Listing
April 2019
2 Reads

Venovenous extracorporeal membrane oxygenation treatment in a low-volume and geographically isolated cardiothoracic centre.

Acta Anaesthesiol Scand 2019 Apr 2. Epub 2019 Apr 2.

Cardiothoracic Surgery, Landspitali University Hospital, Reykjavik, Iceland.

Background: Extracorporeal membrane oxygenation (ECMO) treatment is generally offered in large tertiary cardiothoracic referral centres. Here we present the indications and outcome of venovenous-ECMO (VV-ECMO) treatment in a low-volume, geographically isolated single-centre in Iceland, a country of 350 000 inhabitants. Our hypothesis was that patient survival in such a centre can be similar to that at high-volume centres. Read More

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http://dx.doi.org/10.1111/aas.13367DOI Listing
April 2019
3 Reads

Bivalirudin Anticoagulation for an Infant with Hyperbilirubinemia and Elevated Plasma-Free Hemoglobin on ECMO.

J Extra Corpor Technol 2019 Mar;51(1):26-28

Cleveland Clinic, Heart and Vascular Institute, Cleveland, Ohio.

Heparin has been used for decades as an anticoagulant in patients on mechanical circulatory support, which includes extracorporeal membrane oxygenation (ECMO) and ventricular assist devices. Bivalirudin is a direct thrombin inhibitor that can be used as an alternative anticoagulant in neonates and infants demonstrating inaccurate heparin monitoring. We report a case of a 2-month-old male child who was placed on ECMO for severe acute respiratory distress syndrome. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436166PMC
March 2019
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Clinician-Family Communication About Patients' Values and Preferences in Intensive Care Units.

JAMA Intern Med 2019 Apr 1. Epub 2019 Apr 1.

Program on Ethics and Decision Making in Critical Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Importance: Little is known about whether clinicians and surrogate decision makers follow recommended strategies for shared decision making by incorporating intensive care unit (ICU) patients' values and preferences into treatment decisions.

Objectives: To determine how often clinicians and surrogates exchange information about patients' previously expressed values and preferences and deliberate and plan treatment based on these factors during conferences about prognosis and goals of care for incapacitated ICU patients.

Design, Setting, And Participants: A secondary analysis of a prospective, multicenter cohort study of audiorecorded clinician-family conferences between surrogates and clinicians of 249 incapacitated, critically ill adults was conducted. Read More

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http://dx.doi.org/10.1001/jamainternmed.2019.0027DOI Listing
April 2019
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Mycoplasma Pneumonia: Late Treatment Leading to Acute Respiratory Distress Syndrome and Renal Failure.

Eur J Case Rep Intern Med 2019 13;6(2):001003. Epub 2019 Feb 13.

Wexford General Hospital, Wexford, Ireland.

Introduction: Mycoplasma pneumonia is one of the most common types of pneumonia, although it is often not diagnosed due to mild clinical course.

Aims: In this case study we aim to describe the importance of considering mycoplasma pneumonia in high-risk groups.

Methods: We present the case of a 27-year-old woman admitted with pneumonia, progressing to acute respiratory distress syndrome and acute kidney injury. Read More

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https://www.ejcrim.com/index.php/EJCRIM/article/view/1003
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http://dx.doi.org/10.12890/2019_001003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432824PMC
February 2019
2 Reads

Surgical lung biopsy in onco-hematological patients with diffuse pulmonary infiltrates and mechanical ventilation in the ICU.

Oncol Lett 2019 Apr 21;17(4):3997-4003. Epub 2019 Feb 21.

Department of Critical Care Medicine, Hospital do Câncer/UOPECCAN, Cascavel, Paraná 85806-300, Brazil.

Among onco-hematological patients with acute respiratory failure (ARpF), surgical lung biopsy (SLB) could contribute to the medical management, by guiding initiation, maintenance or discontinuation of diagnostic and therapeutic interventions. The aim of the present study was to evaluate the results of SLB in these patients in an oncological center from a medium-income country, as well as analyze if this procedure is clinically useful in this context, and its impact on complications and mortality. This observational retrospective study analyzed onco-hematological patients with ARpF in the Intensive Care Unit (ICU) of a cancer center in southern Brazil between 2010-2016, who required mechanical ventilation and were submitted to open SLB. Read More

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http://dx.doi.org/10.3892/ol.2019.10065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425415PMC
April 2019
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Pharmacokinetics of Ketamine at Dissociative Doses in an Adult Patient With Refractory Status Asthmaticus Receiving Extracorporeal Membrane Oxygenation Therapy.

Clin Ther 2019 Mar 28. Epub 2019 Mar 28.

Department of Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.

Purpose: First-line management of severe asthma exacerbations include the use of inhaled short-acting β-agonists, anticholinergics, and systemic corticosteroids. Continuous intravenous ketamine given at dissociative doses may be a pharmacologic option in patients who are intubated with life-threatening severe bronchospasm unresponsive to standard therapy. We describe the case of a 44-year-old man admitted to the intensive care unit for status asthmaticus requiring intubation and mechanical ventilation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01492918193011
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http://dx.doi.org/10.1016/j.clinthera.2019.03.005DOI Listing
March 2019
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Lower Extremity Necrotizing Fasciitis in Diabetic and Nondiabetic Patients: Mortality and Amputation.

Int J Low Extrem Wounds 2019 Apr 1:1534734619836464. Epub 2019 Apr 1.

1 University of Texas Southwestern Medical Center, Dallas, TX, USA.

Lower extremity necrotizing fasciitis (NF) is a severe infection requiring immediate surgery. The aim of this study was to assess patient factors predictive of amputation and mortality in diabetes mellitus (DM) and non-DM patients with lower extremity NF. The American College of Surgeons-National Surgical Quality Improvement Program (ACS-NSQIP) database was reviewed retrospectively. Read More

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http://dx.doi.org/10.1177/1534734619836464DOI Listing
April 2019
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New insights into exogenous surfactant as a carrier of pulmonary therapeutics.

Biochem Pharmacol 2019 Mar 27;164:64-73. Epub 2019 Mar 27.

Department of Medicine and Physiology & Pharmacology, Western University, London, Ontario, Canada. Electronic address:

As an organ system, the lung has unique advantages and disadvantages for localized drug delivery. Its direct contact with the external environment allows for the upper airways to be easily accessible to intrapulmonary delivery. However, its complex branching structure makes direct delivery to the peripheral airways challenging. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.03.036DOI Listing
March 2019
1 Read