27,755 results match your criteria Acute Respiratory Distress Syndrome


Preliminary evidence that hydrostatic edema may contribute to the formation of diffuse alveolar damage in a Holstein calf model.

F1000Res 2018 26;7:374. Epub 2018 Mar 26.

Departments of Animal and Food Sciences, College of Agricultural Sciences and Natural Resources, Texas Tech University, Lubbock, TX, 79409, USA.

Two notable findings of clinically healthy feedlot cattle suggest they may have pulmonary hydrostatic edema during the finishing phase of production: increased pulmonary arterial wedge pressures and pulmonary venous hypertrophy. The goal of this study was to determine if increased pulmonary arterial wedge pressure (PAWP) in a Holstein calf could lead to diffuse alveolar damage consistent with the early, exudative phase of acute interstitial pneumonia of feedlot cattle. Six male Holstein dairy calves were given daily subcutaneous injections of the nonspecific ß-adrenergic agonist isoprenaline (10 mg/kg/d), to induce left ventricular diastolic dysfunction, or sterile water for 14 days. Read More

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http://dx.doi.org/10.12688/f1000research.14153.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263485PMC

Doppler-defined pulmonary hypertension in sepsis and septic shock.

J Crit Care 2018 Dec 8;50:201-206. Epub 2018 Dec 8.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, United States.

Background: The association of pulmonary hypertension (PH) in patients with sepsis is lesser understood.

Methods: This was a retrospective study of adult patients admitted to the intensive care unit during 2007-2014 for sepsis and septic shock, with echocardiography performed <72 h. PH was defined as tricuspid regurgitation peak velocity (TRV) > 3 m/s on Doppler echocardiography. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08839441183093
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http://dx.doi.org/10.1016/j.jcrc.2018.12.008DOI Listing
December 2018
2 Reads

Vascular endothelial growth factor increased the permeability of respiratory barrier in acute respiratory distress syndrome model in mice.

Biomed Pharmacother 2019 Jan 30;109:2434-2440. Epub 2018 Nov 30.

Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China. Electronic address:

Background: Acute respiratory distress syndrome is associated with a mortality of 45%. The authors investigated the possible mechanisms and effect of vascular endothelial growth factor on alveolar epithelial barrier permeability in acute respiratory distress syndrome mice model.

Methods: Eighty Male BALB/c mice were randomly assigned to four group: PBS group, LPS group, sFlt group, or LPS + sFlt group. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183403
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http://dx.doi.org/10.1016/j.biopha.2018.11.132DOI Listing
January 2019
2 Reads

A Comparative Review of Neutrophil Extracellular Traps in Sepsis.

Front Vet Sci 2018 28;5:291. Epub 2018 Nov 28.

Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis Davis, CA, United States.

Sepsis is the leading cause of critical illness and mortality in human beings and animals. Neutrophils are the primary effector cells of innate immunity during sepsis. Besides degranulation and phagocytosis, neutrophils also release neutrophil extracellular traps (NETs), composed of cell-free DNA, histones, and antimicrobial proteins. Read More

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http://dx.doi.org/10.3389/fvets.2018.00291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280561PMC
November 2018
1 Read

Standardization of nitric oxide inhalation in extremely preterm infants in Japan.

Pediatr Int 2018 Dec 6. Epub 2018 Dec 6.

Neonatal Intensive Care, Kurashiki Central Hospital, Kurashiki, Okayama, Japan.

Background: In perinatal medicine, inhaled nitric oxide (iNO) has been an important tool for the treatment of full-term and late-preterm infants with persistent pulmonary hypertension of the newborn (PPHN) and hypoxemic respiratory failure (HRF). However, its use in more premature infants is controversial. To evaluate the current clinical practices regarding use of acute inhaled nitric oxide (iNO) therapy in extremely preterm infants, a nationwide survey was conducted in Japan. Read More

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http://dx.doi.org/10.1111/ped.13746DOI Listing
December 2018

[Honokiol attenuates lipopolysaccharide-induced acute respiratory distress syndrome via activation of mitochondrion-dependent Sirt3/AMPK pathway].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Oct;43(10):1075-1082

Department of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.

Objective: To explore the effects of honokiol (HKL) on pulmonary microvascular endothelial cells in lipopolysaccharide (LPS)-induced acute respiratory distress syndrome (ARDS) and the underlying mechanisms.
 Methods: In animal experiment, a total of 40 C57BL/6J mice were randomly divided into a control group (Con group), a LPS intervention group (LPS group), a LPS+honokiol (HKL) intervention group (HKL group) and a LPS+HKL+nicotinamide (NAM) intervention group (NAM group) (n=10 in each group). In the cell experiment, the experiment cells were divided into a control group (Con group), a LPS intervention group (LPS group), a LPS+HKL intervention group (HKL group), a LPS+HKL+NAM intervention group (NAM group), and a LPS+HKL+compound C (CMC) intervention group (CMC group). Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.10.006DOI Listing
October 2018

Acute Respiratory Distress Syndrome and Prone Positioning.

AACN Adv Crit Care 2018 ;29(4):415-425

Dannette A. Mitchell is Critical Care Clinical Nurse Specialist, Christiana Care Health Service, Wilmington Hospital, 501 W 14th Street, Intensive Care and Transitional Care Unit - 6S45, Wilmington, DE 19801 Maureen A. Seckel is Lead Critical Care Clinical Nurse Specialist and Sepsis Leader, Christiana Care Health Service, Christiana Hospital, Newark, Delaware.

Acute respiratory distress syndrome continues to have high morbidity and mortality despite more than 50 years of research. The Berlin definition in 2012 established risk stratification based on degree of hypoxemia and the use of positive end-expiratory pressure. The use of prone positioning as a treatment modality has been studied for more than 40 years, with recent studies showing an improvement in oxygenation and decreased mortality. Read More

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http://dx.doi.org/10.4037/aacnacc2018161DOI Listing
January 2018

[The role and mechanism of regulatory T cells in indirect acute lung injury].

Zhonghua Jie He He Hu Xi Za Zhi 2018 Dec;41(12):959-966

Department of General Medicine, Tianjin Occupational Diseases Precaution and Therapeutic Hospital, Tianjin 300070, China.

To study the role and mechanism of CD(4)(+) CD(25)(+) FoxP3(+) regulatory T cells (Tregs) in the pathophysiological process of indirect acute lung injury (iALI) in mice. The iALI model was successfully induced by shock/cecal ligation and puncture method. Sham (8), cecal ligation and puncture (CLP, 10), and hemorrhage (Hem, 12) groups were established as controls. Read More

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December 2018

Point-of-care lung ultrasound for the detection of pulmonary manifestations of malaria and sepsis: An observational study.

PLoS One 2018 12;13(12):e0204832. Epub 2018 Dec 12.

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Introduction: Patients with severe malaria or sepsis are at risk of developing life-threatening acute respiratory distress syndrome (ARDS). The objective of this study was to evaluate point-of-care lung ultrasound as a novel tool to determine the prevalence and early signs of ARDS in a resource-limited setting among patients with severe malaria or sepsis.

Materials And Methods: Serial point-of-care lung ultrasound studies were performed on four consecutive days in a planned sub study of an observational cohort of patients with malaria or sepsis in Bangladesh. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204832PLOS
December 2018

Activating Mas receptor protects human pulmonary microvascular endothelial cells against LPS-induced apoptosis via the NF-kB p65/P53 feedback pathways.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Critical Care Medicine, Shanghai Jiaotong University affiliated to The Sixth People's Hospital, Shanghai, China.

The balance between Ang II/AT1R and Ang-(1-7)/Mas plays a pivotal role in the development of lipopolysaccharides (LPS)-induced acute respiratory distress syndrome. However, the mechanisms underlying the balancing process still remain unclear. Here we investigated the roles of nuclear factor (NF)-κB and p53 in regulating AT1R and Mas expression. Read More

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http://dx.doi.org/10.1002/jcp.27951DOI Listing
December 2018

Effect of body position and inclination in supine and prone position on respiratory mechanics in acute respiratory distress syndrome.

Intensive Care Med 2018 Dec 7. Epub 2018 Dec 7.

Service de Médecine Intensive-Réanimation, Hôpital de La Croix-Rousse, Hospices civils de Lyon, Lyon, France.

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http://dx.doi.org/10.1007/s00134-018-5493-1DOI Listing
December 2018

Hemodynamic effects of extended prone position sessions in ARDS.

Ann Intensive Care 2018 Dec 7;8(1):120. Epub 2018 Dec 7.

Service de Réanimation Médicale, Hôpital De La Croix Rousse, Hospices Civils de Lyon, 103 Grande Rue de la Croix Rousse, 69004, Lyon, France.

Background: Hemodynamic response to prone position (PP) has never been studied in a large series of patients with acute respiratory distress syndrome (ARDS). The primary aim of this study was to estimate the rate of PP sessions associated with cardiac index improvement. Secondary objective was to describe hemodynamic response to PP and during the shift from PP to supine position. Read More

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https://annalsofintensivecare.springeropen.com/articles/10.1
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http://dx.doi.org/10.1186/s13613-018-0464-9DOI Listing
December 2018
1 Read

Driving pressure and long-term outcomes in moderate/severe acute respiratory distress syndrome.

Ann Intensive Care 2018 Dec 7;8(1):119. Epub 2018 Dec 7.

Divisão de Pneumologia, Cardiopulmonary Department, Heart Institute (InCor) University of São Paulo, INCOR Av. Dr. Enéas de Carvalho Aguiar, 44 Pinheiros, São Paulo, SP, CEP 05403-900, Brazil.

Background: Acute respiratory distress syndrome (ARDS) patients may present impaired in lung function and structure after hospital discharge that may be related to mechanical ventilation strategy. The aim of this study was to evaluate the association between functional and structural lung impairment, N-terminal-peptide type III procollagen (NT-PCP-III) and driving pressure during protective mechanical ventilation. It was a secondary analysis of data from randomized controlled trial that included patients with moderate/severe ARDS with at least one follow-up visit performed. Read More

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http://dx.doi.org/10.1186/s13613-018-0469-4DOI Listing
December 2018

Pulsed Dose Oxygen Delivery During Mechanical Ventilation: Impact on Oxygenation.

Mil Med 2018 Dec 7. Epub 2018 Dec 7.

University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH.

Introduction: Adequate oxygenation is one of the primary goals of mechanical ventilation. Maintenance of adequate oxygenation and prevention of hypoxemia are the primary goals for the battlefield casualty, but military operations have unique concerns. In military operations, oxygen is a limited resource. Read More

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http://dx.doi.org/10.1093/milmed/usy362DOI Listing
December 2018

Respiratory failure requiring mechanical ventilation in critically ill adults in Ghana: A prospective observational study.

Afr J Emerg Med 2018 Dec 20;8(4):155-157. Epub 2018 Sep 20.

Department of Emergency Medicine, University of Florida, Gainesville, FL, USA.

Introduction: Respiratory failure is commonly seen in African emergency centres and intensive care units, but little is known about the need for intubation and mechanical ventilation.

Methods: From April to October 2017, we recorded the number of patients intubated and ventilated in the emergency centre and intensive care unit at Komfo Anokye Teaching Hospital in Kumasi, Ghana on a daily basis. We assessed patients for presence of acute respiratory distress syndrome (ARDS) using the Kigali Modification of the Berlin ARDS criteria. Read More

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http://dx.doi.org/10.1016/j.afjem.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277501PMC
December 2018

Bedside respiratory physiology to detect risk of lung injury in acute respiratory distress syndrome.

Authors:
Jeremy R Beitler

Curr Opin Crit Care 2019 Feb;25(1):3-11

Division of Pulmonary, Allergy, and Critical Care Medicine, Center for Acute Respiratory Failure, Columbia University College of Physicians and Surgeons, New York, New York, USA.

Purpose Of Review: The most effective strategies for treating the patient with acute respiratory distress syndrome center on minimizing ventilation-induced lung injury (VILI). Yet, current standard-of-care does little to modify mechanical ventilation to patient-specific risk. This review focuses on evaluation of bedside respiratory mechanics, which when interpreted in patient-specific context, affords opportunity to individualize lung-protective ventilation in patients with acute respiratory distress syndrome. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000579DOI Listing
February 2019

Rare respiratory diseases in the ICU: when to suspect them and specific approaches.

Curr Opin Crit Care 2019 Feb;25(1):29-36

Université Paris Est Créteil, Faculté de Médecine de Créteil, Groupe de Recherche Clinique CARMAS, Créteil.

Purpose Of Review: A prompt identification of the cause of acute respiratory failure (ARF)/acute respiratory distress syndrome (ARDS) is required in order to initiate a targeted treatment. Yet, almost 10% of ARDS patients have no identified ARDS risk factor at ARDS diagnosis. Numerous rare causes of ARF have been reported in this setting. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000572DOI Listing
February 2019
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Phenotypes in acute respiratory distress syndrome: moving towards precision medicine.

Curr Opin Crit Care 2019 Feb;25(1):12-20

Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine.

Purpose Of Review: To provide an overview of the current research in identifying homogeneous subgroups and phenotypes in ARDS.

Recent Findings: In recent years, investigations have used either physiology, clinical data, biomarkers or a combination of these to stratify patients with ARDS into distinct subgroups with divergent clinical outcomes. In some studies, there has also been evidence of differential treatment response within subgroups. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000571DOI Listing
February 2019

Central diabetes insipidus: A rare complication of IVH in a very low birth weight preterm infant.

J Neonatal Perinatal Med 2018 Dec 1. Epub 2018 Dec 1.

Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, LA, USA.

A 710 g male infant was born at a referring hospital at a gestational age of 23 weeks and 2 days via vaginal delivery and was transferred to our facility at 14 days of age. His delivery was complicated by the breech presentation with difficult head extraction. The infant's initial course was significant for respiratory distress syndrome, grade III-IV intraventricular hemorrhage (IVH), acute kidney injury, and large PDA. Read More

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http://dx.doi.org/10.3233/NPM-1837DOI Listing
December 2018

Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1.

J Immunol 2018 Dec 7. Epub 2018 Dec 7.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611;

Muscle dysfunction is common in patients with adult respiratory distress syndrome and is associated with morbidity that can persist for years after discharge. In a mouse model of severe influenza A pneumonia, we found the proinflammatory cytokine IL-6 was necessary for the development of muscle dysfunction. Treatment with a Food and Drug Administration-approved Ab antagonist to the IL-6R (tocilizumab) attenuated the severity of influenza A-induced muscle dysfunction. Read More

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http://dx.doi.org/10.4049/jimmunol.1701433DOI Listing
December 2018

Blocking of tripartite motif 8 protects against lipopolysaccharide (LPS)-induced acute lung injury by regulating AMPKα activity.

Biochem Biophys Res Commun 2018 Dec 4. Epub 2018 Dec 4.

Department of Laboratory, Ankang Central Hospital, No. 85, Jinzhou South Road, Hanbin District, Ankang, 725000, China. Electronic address:

Acute lung injury (ALI) and its more serious form, respiratory distress syndrome (ARDS), are considered as an acute and severe inflammatory process existing in lungs, and still remain high mortality rates. Tripartite motif 8 (TRIM8) contains an N-terminal RING finger, which is followed by two B-boxes and a coiled-coil domain, belonging to the TRIM/RBCC family and playing significant role in meditating inflammation, oxidative stress and apoptosis. In the study, we investigated the role of TRIM8 in ALI induced by lipopolysaccharide (LPS) and the underlying molecular mechanisms. Read More

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http://dx.doi.org/10.1016/j.bbrc.2018.11.072DOI Listing
December 2018

Sedation Management for Critically Ill Children with Pre-Existing Cognitive Impairment.

J Pediatr 2018 Dec 5. Epub 2018 Dec 5.

The Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA; Department of Family and Community Health, School of Nursing, Department of Anesthesia and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address:

Objective: To compare current analgesia and sedation management practices between critically ill children with pre-existing cognitive impairment and critically ill neurotypical children, including possible indicators of therapeutic efficacy.

Study Design: This study used secondary analysis of prospective data from the RESTORE clinical trial, with 2449 children admitted to the pediatric intensive care unit and receiving mechanical ventilation for acute respiratory failure. Subjects with a baseline Pediatric Cerebral Performance Category ≥3 were defined as subjects with cognitive impairment, and differences between groups were explored using regression methods accounting for pediatric intensive care unit as a cluster variable. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.10.042DOI Listing
December 2018

Risk factors and the associated limit values for abnormal elevation of extravascular lung water in severely burned adults.

Burns 2018 Dec 7. Epub 2018 Dec 7.

Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China. Electronic address:

Background: Increased extravascular lung water (EVLW) correlates with pulmonary morbidity and mortality in critical illness. The extravascular lung water index (EVLWI), which reflects the degree of EVLW in an individual, increases in the fluid reabsorption stage rather than the initial resuscitation stage in severe burn cases. While many factors contribute to EVLWI variation, the risk factors contributing to its abnormal elevation in severe burns remain unclear. Read More

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http://dx.doi.org/10.1016/j.burns.2018.11.007DOI Listing
December 2018
1 Read

The Potential Dangers of Recruitment Maneuvers During One Lung Ventilation Surgery.

J Surg Res 2019 Feb 11;234:178-183. Epub 2018 Oct 11.

Division of Thoracic Surgery, Western University, London, Ontario, Canada.

Background: Existing evidence regarding lung-protective ventilation (LPV) during one-lung ventilation (OLV) focuses on surrogate outcomes. Our objective was to assess whether an LPV protocol during OLV surgery is associated with reduced respiratory complications.

Materials And Methods: This was a matched control retrospective cohort study of patients undergoing pulmonary resection at a tertiary Canadian hospital. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804183064
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http://dx.doi.org/10.1016/j.jss.2018.09.024DOI Listing
February 2019
2 Reads

Escherichia coli lipopolysaccharide induces alveolar epithelial cell stiffening.

J Biomech 2018 Nov 29. Epub 2018 Nov 29.

Unitat de Biofísica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias CIBERES, Madrid, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain. Electronic address:

Introduction: Application of lipopolysaccharide (LPS) is a widely employed model to mimic acute respiratory distress syndrome (ARDS). Available data regarding LPS-induced biomechanical changes on pulmonary epithelial cells are limited only to P. aeruginosa LPS. Read More

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http://dx.doi.org/10.1016/j.jbiomech.2018.11.034DOI Listing
November 2018

Electronic "Sniffer" Systems to Identify the Acute Respiratory Distress Syndrome: A Systematic Review.

Ann Am Thorac Soc 2018 Dec 6. Epub 2018 Dec 6.

University of Michigan, Internal Medicine, Ann Arbor, Michigan, United States ;

Background: The acute respiratory distress syndrome (ARDS) results in substantial mortality but remains underdiagnosed in clinical practice. Automated ARDS "sniffer" systems, tools that can automatically analyze electronic medical record data, have been developed to improve recognition of ARDS in clinical practice.

Objective: To perform a systematic review examining the evidence underlying automated sniffer systems for ARDS detection. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201810-715OCDOI Listing
December 2018
2 Reads

Identification and Modulation of Microenvironment is Crucial for Effective MSC Therapy in Acute Lung Injury.

Am J Respir Crit Care Med 2018 Dec 6. Epub 2018 Dec 6.

The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, Critical Care Medicine, Guangzhou, Guangdong, China.

Rationale: There are controversial reports on applications of mesenchymal stromal cells (MSCs) in patients with acute respiratory distress syndrome (ARDS).

Objective: We hypothesized that lung microenvironment was the main determinant of beneficial versus detrimental effects of MSCs during ARDS.

Methods: Lung proteome was profiled in three models of injury induced by acid instillation and/or mechanical ventilation in mice. Read More

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https://www.atsjournals.org/doi/10.1164/rccm.201802-0356OC
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http://dx.doi.org/10.1164/rccm.201802-0356OCDOI Listing
December 2018
6 Reads

Acute respiratory distress syndrome (ARDS) phenotyping.

Intensive Care Med 2018 Dec 5. Epub 2018 Dec 5.

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.

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http://link.springer.com/10.1007/s00134-018-5480-6
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http://dx.doi.org/10.1007/s00134-018-5480-6DOI Listing
December 2018
4 Reads

A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.

JCI Insight 2018 Dec 6;3(23). Epub 2018 Dec 6.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.

Background: Acute respiratory distress syndrome (ARDS) is a prevalent disease with significant mortality for which no effective pharmacologic therapy exists. Low-dose inhaled carbon monoxide (iCO) confers cytoprotection in preclinical models of sepsis and ARDS.

Methods: We conducted a phase I dose escalation trial to assess feasibility and safety of low-dose iCO administration in patients with sepsis-induced ARDS. Read More

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http://dx.doi.org/10.1172/jci.insight.124039DOI Listing
December 2018
2 Reads

Pulmonary veno-occlusive disease as a cause of severe pulmonary hypertension in a dog.

Acta Vet Scand 2018 Dec 5;60(1):78. Epub 2018 Dec 5.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3508 TD, Utrecht, The Netherlands.

Background: Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary arterial hypertension (PAH) in humans and can be classified in idiopathic, heritable, drug and radiation-induced, and associated with connective tissue disease or human immunodeficiency virus infection. Recently, biallelic mutations of the EIF2AK4 gene have been discovered as a cause for an autosomal recessive form of PVOD in humans. In dogs, PAH is poorly characterized and is generally considered to be idiopathic or secondary to (for example) congenital left-to right cardiovascular shunts or heartworm disease. Read More

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https://actavetscand.biomedcentral.com/articles/10.1186/s130
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http://dx.doi.org/10.1186/s13028-018-0433-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282261PMC
December 2018
3 Reads

Impact of cannula design on packed red blood cell transfusions: technical advancement to improve outcomes in extracorporeal membrane oxygenation.

J Thorac Dis 2018 Oct;10(10):5813-5821

Department of Anesthesia and Intensive Care, IRCCS - ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), Palermo, Italy.

Background: Technological improvement has contributed to making veno-venous extracorporeal membrane oxygenation (VV-ECMO) safer and easier, spreading its use in acute respiratory failure (ARF).

Methods: This is a retrospective observational study carried out in the ECMO center at IRCCS-ISMETT, a medical center focused on end-stage organ failure treatment in Italy. We investigated the effect of different cannula designs on the amount of blood product transfused. Read More

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http://dx.doi.org/10.21037/jtd.2018.09.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236184PMC
October 2018
1 Read

Clinical differences between pulmonary and extrapulmonary acute respiratory distress syndrome: a retrospective cohort study of prospectively collected data in Japan.

J Thorac Dis 2018 Oct;10(10):5796-5803

Division of Respiratory Medicine, Saiseikai Kumamoto Hospital, Kumamoto, Japan.

Background: Although acute respiratory distress syndrome (ARDS) reportedly shows various clinical phenotypes with different risk and prognostic factors, few studies have assessed the clinical features and prognosis of pulmonary and extrapulmonary ARDS. The aim of the present study was to investigate clinical differences between pulmonary and extrapulmonary ARDS.

Methods: In total, 200 patients who met the Berlin criteria and were diagnosed with ARDS between October 2004 and September 2017 were included. Read More

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http://dx.doi.org/10.21037/jtd.2018.09.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236192PMC
October 2018

A modified acute respiratory distress syndrome prediction score: a multicenter cohort study in China.

J Thorac Dis 2018 Oct;10(10):5764-5773

Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.

Background: Early recognition of the risks of acute respiratory distress syndrome (ARDS) and prevention of the development of ARDS may be more effective in improving patient outcomes. We performed the present study to determine the ARDS risk factors in a Chinese population and validate a score to predict the development of ARDS.

Methods: This was an observational multicenter cohort study performed in 13 tertiary hospitals in China. Read More

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http://dx.doi.org/10.21037/jtd.2018.09.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236166PMC
October 2018
1 Read

Extracorporeal membrane oxygenation with prone position ventilation successfully rescues infantile pertussis: a case report and literature review.

BMC Pediatr 2018 Nov 30;18(1):377. Epub 2018 Nov 30.

Department of Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, No.355 Luding Road, Putuo District, Shanghai, 200062, China.

Background: Bordetella pertussis can cause fatal illness with severe acute respiratory distress syndrome (ARDS) and pulmonary hypertension (PHT).

Case Presentation: A 6-month-old non-vaccinated boy with B. pertussis infection who developed ARDS was treated by extracorporeal membrane oxygenation (ECMO). Read More

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http://dx.doi.org/10.1186/s12887-018-1351-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267074PMC
November 2018
1 Read

[Multicenter investigation of extracorporeal membrane oxygenation application in pediatric intensive care unit in China].

Zhonghua Er Ke Za Zhi 2018 Dec;56(12):929-932

Department of Pediatric Emergency Medicine, Children's Hospital of Fudan University, Shanghai 201102, China.

To survey the conduction and evaluate the effectiveness of extracorporeal membrane oxygenation (ECMO) therapy in pediatric intensive care unit (PICU) in China mainland. In a questionnaire-based survey, we retrospectively reviewed the application of ECMO in children's hospital and general hospital in China mainland to summarize and analyze the categories of diseases and prognosis of children treated with ECMO therapy. By December 31, 2017, a total of 23 hospitals using ECMO, including 22 tertiary referral hospitals and 1 secondary hospital, among which 16 were children's hospitals and 7 were general hospitals. Read More

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December 2018
4 Reads

Combined Off-Pump Coronary Artery Bypass Grafting and Lung Resection in Patients with Lung Cancer Accompanied by Coronary Artery Disease.

Braz J Cardiovasc Surg 2018 Sep-Oct;33(5):483-489

Yuzuncu Yil University School of Medicine Gaziosmanpasa Hospital, Department of Thoracic Surgery, Istanbul, Turkey.

Introduction: Optimal surgical approach for the treatment of resectable lung cancer accompanied by coronary artery disease (CAD) remains a contentious issue. In this study, we present our cases that were operated simultaneously for concurrent lung cancer and CAD.

Methods: Simultaneous off-pump coronary artery bypass surgery (OPCABG) and lung resection were performed on 10 patients in our clinic due to lung cancer accompanied by CAD. Read More

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http://www.bjcvs.org/pdfRBCCV/v33n5a10.pdf
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http://dx.doi.org/10.21470/1678-9741-2018-0126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257540PMC
April 2018
2 Reads

Recent advances in venovenous extracorporeal membrane oxygenation for severe acute respiratory distress syndrome.

Curr Opin Crit Care 2019 Feb;25(1):71-76

Sorbonne Université, INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition.

Purpose Of Review: To summarize results of the most recent trials on venovenous extracorporeal membrane oxygenation (VV-ECMO) in severe acute respiratory distress syndrome (ARDS) and to elaborate on the unmet needs regarding VV-ECMO management in this setting.

Recent Findings: Although it was terminated early for futility (i.e. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000567DOI Listing
February 2019
1 Read

Airway pressure release ventilation in children.

Curr Opin Crit Care 2019 Feb;25(1):63-70

Department of Critical Care Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Canada.

Purpose Of Review: In patients with acute respiratory distress syndrome (ARDS), airway pressure release ventilation (APRV) has been purported to have several physiological benefits. This review synthesizes recent research evaluating APRV mode and provides perspectives on the utility of this mode in children with ARDS.

Recent Findings: Two single-center clinical trials on APRV, one adult and one pediatric, have been published this year. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000575DOI Listing
February 2019

Noninvasive approach for de novo acute hypoxemic respiratory failure: noninvasive ventilation, high-flow nasal cannula, both or none?

Curr Opin Crit Care 2019 Feb;25(1):54-62

Critical Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.

Purpose Of Review: To summarize the recent evidence regarding the use of noninvasive strategies for de novo acute hypoxemic respiratory failure (AHRF).

Recent Findings: New guidelines for the use of noninvasive ventilation (NIV) in acute respiratory failure have been published. In parallel, high-flow nasal cannula (HFNC) is an emerging noninvasive strategy for AHRF patients. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000570DOI Listing
February 2019

MicroRNA-34a Promotes Endothelial Dysfunction and Mitochondrial-Mediated Apoptosis in Murine Models of Acute Lung Injury.

Am J Respir Cell Mol Biol 2018 Dec 4. Epub 2018 Dec 4.

Drexel University College of Medicine, Department of Pediatrics, Philadelphia, Pennsylvania, United States.

Recent evidence has shown that microRNA (miRNAs) are involved in endothelial dysfunction and vascular injury in lung-related diseases. However, the potential role of miR-34a in the regulation of pulmonary endothelial dysfunction, vascular injury and endothelial cells (ECs) apoptosis in acute lung injury (ALI)/acute lung respiratory distress syndrome (ARDS) is largely unknown. Here, we show that miR-34a-5p was up-regulated in whole lungs, isolated ECs from lungs and ECs stimulated with various insults (lipopolysaccharide and hyperoxia). Read More

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http://dx.doi.org/10.1165/rcmb.2018-0194OCDOI Listing
December 2018
1 Read

Anti-inflammatory effect of a curcumin-aspirin derivative on Ureaplasma-induced cytokine expressions in neonatal monocytes.

Cell Mol Biol (Noisy-le-grand) 2018 Nov 30;64(14):61-65. Epub 2018 Nov 30.

Obstetrics, Baoji Traditional Chinese Medicine Hospital, Baoji City, Shaanxi Province, 721000, China.

One of the major contributors to death in infants is infant respiratory distress syndrome (IRDS). The transition from early acute inflammation to fibrotic hyperplasia is important in the development of IRDS. However, there are no available and effective remedies for suppression of the early inflammation. Read More

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November 2018

Intravascular large B-cell lymphoma presenting with diffusely increased pulmonary fluorodeoxyglucose uptake without corresponding CT abnormality.

Radiol Case Rep 2019 Feb 23;14(2):260-264. Epub 2018 Nov 23.

Department of Radiology, Kansas University Hospital, 3901 Rainbow Blvd, MS 4032, Kansas City, KS, USA.

A 60-year-old male presented with complaints of dyspnea, intermittent fever, and 40 pounds of weight loss over the previous 9 months and was admitted for acute hypoxemic respiratory failure. Labs demonstrated elevated inflammatory markers, mild anemia, and thrombocytopenia. Fluorodeoxyglucose-positron emission tomography scan demonstrated diffusely increased pulmonary fluorodeoxyglucose uptake without corresponding abnormality on CT images. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19300433183045
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http://dx.doi.org/10.1016/j.radcr.2018.10.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260434PMC
February 2019
2 Reads

miR-146b overexpression ameliorates lipopolysaccharide-induced acute lung injury in vivo and in vitro.

J Cell Biochem 2018 Nov 30. Epub 2018 Nov 30.

Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China.

Acute respiratory distress syndrome (ARDS) is a type of acute lung injury (ALI), which causes high morbidity and mortality. So far, effective clinical treatment of ARDS is still limited. Recently, miR-146b has been reported to play a key role in inflammation. Read More

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http://dx.doi.org/10.1002/jcb.26846DOI Listing
November 2018
1 Read

Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study.

Anesthesiology 2018 Nov 27. Epub 2018 Nov 27.

From the Interdepartmental Division of Critical Care Medicine (T.P., J.G.L., E.F., L.J.B.) Department of Anesthesia (J.G.L.) Institute of Health Policy, Management and Evaluation (E.F.) University of Toronto, Toronto, Canada; Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute (T.P., J.G.L., L.J.B.) Department of Anesthesia (J.G.L.) St. Michael's Hospital, Toronto, Canada Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil (A.S.N.) Department of Intensive Care (A.S.N., M.J.S.) Laboratory of Experimental Intensive Care and Anesthesiology (M.J.S.) Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands; Department of Clinical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy (P.P.) San Martino Policlinico Hospital, Istituto di Ricovero e Cura a Carattere Scientifico for Oncology, Genoa, Italy (P.P.) Department of Anaesthesia, School of Medicine, and Regenerative Medicine Institute at C RAM Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland (J.G.L.) Critical Care Area, Parc Tauli Hospital University, Autonomous University of Barcelona, Barcelona, Spain (C.D.H.) Respiratory Diseases Network Biomedical Investigation Center, Barcelona, Spain (C.D.H., J.A.L., A.A.) Critical Care Department, University Hospital of Getafe, Madrid, Spain (J.A.L.) European University, Madrid, Spain (J.A.L.) School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy (G.B.) Department of Emergency and Intensive Care, San Gerardo Hospital, Monza, Italy (G.B.) Department of Medicine, University Health Network and Mount Sinai Hospital, Toronto, Canada (E.F.) Department of Anesthesia, Critical Care and Emergency Medicine, Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico Milan, Milan, Italy (A.P.) Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy (A.P.) Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand (M.J.S.) Critical Care Department, Parc Tauli Health Corporation University, Autonomous University of Barcelona, Sabadell and Intensive Care Department, University Hospitals Sagrado Corazon-General de Cataluña, Quiron Salut, Barcelona-Sant Cugat del Valles, Spain (A.A.).

What We Already Know About This Topic: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Patients with initial mild acute respiratory distress syndrome are often underrecognized and mistakenly considered to have low disease severity and favorable outcomes. They represent a relatively poorly characterized population that was only classified as having acute respiratory distress syndrome in the most recent definition. Our primary objective was to describe the natural course and the factors associated with worsening and mortality in this population. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002508DOI Listing
November 2018
4 Reads

The Pathogenic Involvement of Neutrophils in Acute Respiratory Distress Syndrome and Transfusion-Related Acute Lung Injury.

Transfus Med Hemother 2018 Oct 21;45(5):290-298. Epub 2018 Sep 21.

Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden.

The acute respiratory distress syndrome (ARDS) is a serious and common complication of multiple medical and surgical interventions, with sepsis, pneumonia, and aspiration of gastric contents being common risk factors. ARDS develops within 1 week of a known clinical insult or presents with new/worsening respiratory symptoms if the clinical insult is unknown. Approximately 40% of the ARDS cases have a fatal outcome. Read More

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http://dx.doi.org/10.1159/000492950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257140PMC
October 2018
3 Reads

Acute Respiratory Failure and Pulmonary Complications in End-Stage Liver Disease.

Semin Respir Crit Care Med 2018 Oct 28;39(5):546-555. Epub 2018 Nov 28.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.

Acute respiratory failure has a high mortality in patients with end-stage liver disease (ESLD). These patients may develop acute respiratory failure for reasons specific to advanced liver disease, including hepatopulmonary syndrome, portopulmonary hypertension, and hepatic hydrothorax. They may also develop respiratory complications due to conditions seen in the general intensive care unit population to which ESLD patients are at higher risk, including infection, volume overload, and the acute respiratory distress syndrome. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1673638
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http://dx.doi.org/10.1055/s-0038-1673638DOI Listing
October 2018
4 Reads

Cell Death in the Lung: The Apoptosis-Necroptosis Axis.

Annu Rev Physiol 2018 Nov 28. Epub 2018 Nov 28.

Department of Medicine, Yale School of Medicine, New Haven, Connecticut 06520, USA; email:

Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; however, new modalities of caspase-independent regulated cell death have been identified, including necroptosis, pyroptosis, and autophagic cell death. As an understanding of the cellular mechanisms that mediate regulated cell death continues to grow, there is increasing evidence that these pathways are implicated in the pathogenesis of many pulmonary disorders. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-physiol-02
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http://dx.doi.org/10.1146/annurev-physiol-020518-114320DOI Listing
November 2018
2 Reads

Unexpected postpneumonectomy exertion-induced acute right heart failure.

Tumori 2018 Nov 28:300891618812682. Epub 2018 Nov 28.

4 Department of Anesthesia, Intensive Care and Palliative Care, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Introduction:: Thoracic surgery can have serious side effects. Accurate preoperative evaluation to assess which patients with anatomically resectable disease are suitable candidates for surgery is mandatory.

Case Description:: A 58-year-old man, scheduled for left pneumonectomy for lung cancer, passed all the preoperative examinations suggested by guidelines and underwent the surgery. Read More

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http://dx.doi.org/10.1177/0300891618812682DOI Listing
November 2018
3 Reads

Muse Cells and Ischemia-Reperfusion Lung Injury.

Adv Exp Med Biol 2018 ;1103:293-303

Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

Ischemia-reperfusion injury (IRI) is one of the main causes of primary graft dysfunction that accounts for 25% of mortality after lung transplantation. Disruption of blood supply and subsequent reperfusion result in organ damage with activating innate and adaptive immune response, leading to inflammatory insults. The IRI after lung transplantation is primarily manifested by permeability pulmonary edema on the basis of pulmonary vascular endothelial cell injury as seen in acute respiratory distress syndrome (ARDS). Read More

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http://link.springer.com/10.1007/978-4-431-56847-6_16
Publisher Site
http://dx.doi.org/10.1007/978-4-431-56847-6_16DOI Listing
January 2018
4 Reads