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    1 OF 506

    Importance of metabolism variations in a model of extracorporeal carbon dioxide removal.
    Conf Proc IEEE Eng Med Biol Soc 2016 Aug;2016:4264-4267
    Extracorporeal CO2 Removal device is used in clinics when a patient suffers from a pulmonary insufficiency like Acute Respiratory Distress Syndrome and allows to decarboxylate blood externally. In this work, a model of the respiratory system coupled with such a device is proposed to analyze the decrease of CO2 partial pressure in blood. To validate the model, some parameters are estimated thanks to experimental data. Read More

    Creating virtual ARDS patients.
    Conf Proc IEEE Eng Med Biol Soc 2016 Aug;2016:2729-2732
    This paper presents the methodology used in patient-specific calibration of a novel highly integrated model of the cardiovascular and pulmonary pathophysiology associated with Acute Respiratory Distress Syndrome (ARDS). We focus on data from previously published clinical trials on the static and dynamic cardio-pulmonary responses of three ARDS patients to changes in ventilator settings. From this data, the parameters of the integrated model were identified using an optimization-based methodology in multiple stages. Read More

    Central retinal artery occlusion associated with severe ovarian hyperstimulation syndrome.
    Eur J Ophthalmol 2001 Jul-Sep 2001;11(3):313-315
    Department of Obstetrics and Gynecology.
    Purpose: Ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic complication of ovulation induction. It is a potentially lethal condition, with severe complications which include ovarian enlargement, and massive fluid redistribution from the vascular system into free spaces resulting in ascites, pleural effusion, electrolyte imbalance, hemoconcentration, hypovolemia, oliguria, and adult respiratory distress syndrome. Thromboembolism is a rare but extremely serious complication. Read More

    Continuous blood purification treatment for endotoxin-induced acute respiratory distress syndrome.
    Braz J Med Biol Res 2017 Feb 16;50(2):e5367. Epub 2017 Feb 16.
    Intensive Care Unit, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Taizhou, China.
    This study aimed to explore the effects of continuous blood purification (CBP) treatment in pigs affected with acute respiratory distress syndrome (ARDS). A total of 12 healthy male pigs, weighing 12±1.8 kg, were randomly and equally assigned to the control and experimental groups. Read More

    Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome.
    World J Crit Care Med 2017 Feb 4;6(1):85-90. Epub 2017 Feb 4.
    Alpha A Fowler III, Rajiv Malhotra, Orlando Debesa, Ramesh Natarajan, Bernard J Fisher, Aamer Syed, Christine DeWilde, Anna Priday, Division of Pulmonary Disease and Critical Care Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, United States.
    We report a case of virus-induced acute respiratory distress syndrome (ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection. From very significant preclinical research performed at Virginia Commonwealth University with vitamin C and with the very positive results of a previously performed phase I safety trial infusing high dose vitamin C intravenously into patients with severe sepsis, we reasoned that infusing identical dosing to a patient with ARDS from viral infection would be therapeutic. Read More

    Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome.
    World J Crit Care Med 2017 Feb 4;6(1):74-78. Epub 2017 Feb 4.
    Martin Albert, Departments of Intensive Care and Medicine, Hôpital du Sacré-Coeur, de Montréal Research Center, Université de Montréal, Montréal H4J 1C5, Canada.
    Aim: To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome (ARDS).

    Methods: Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of iNO (20 ppm) or nebulized epoprostenol (10 μg/mL) was done in all patients. Read More

    Preventative effect of OMZ-SPT on lipopolysaccharide-induced acute lung injury and inflammation via nuclear factor-kappa B signaling in mice.
    Biochem Biophys Res Commun 2017 Feb 20. Epub 2017 Feb 20.
    Pediatrics Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China; Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China. Electronic address:
    Acute lung injury (ALI) is an early pathophysiologic change in acute respiratory distress syndrome and its management can be challenging. Omalizumab (Xolair™) is a recombinant DNA-derived, humanized antibody. OMZ-SPT is a polypeptide on the heavy chain of omalizumab monoclonal antibody. Read More

    Can body mass index predict clinical outcomes for patients with acute lung injury/acute respiratory distress syndrome? A meta-analysis.
    Crit Care 2017 Feb 22;21(1):36. Epub 2017 Feb 22.
    Departments of Respiratory Diseases, West China School of Medicine and West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China.
    Background: The effects of body mass index (BMI) on the prognosis of acute respiratory distress syndrome (ARDS) are controversial. We aimed to further determine the relationship between BMI and the acute outcomes of patients with ARDS.

    Methods: We searched the Pubmed, Embase, Medline, Cochrane Central Register of Controlled Trials (CENTRAL), and ISI Web of Science for trials published between 1946 and July 2016, using "BMI" or "body mass index" or "overweight" or "obese" and "ARDS" or "ALI" or "acute respiratory distress syndrome" or "acute lung injury", without limitations on publication type or language. Read More

    ANLN truncation causes a familial fatal acute respiratory distress syndrome in Dalmatian dogs.
    PLoS Genet 2017 Feb 21;13(2):e1006625. Epub 2017 Feb 21.
    Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
    Acute respiratory distress syndrome (ARDS) is the leading cause of death in critical care medicine. The syndrome is typified by an exaggerated inflammatory response within the lungs. ARDS has been reported in many species, including dogs. Read More

    Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome.
    Intensive Care Med 2017 Feb 20. Epub 2017 Feb 20.
    Réanimation des Détresses Respiratoires et Infections Sévères, Hôpital NordAix-Marseille Univ, Assistance Publique-Hôpitaux de Marseille, Marseille, France.

    Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a two-by-two factorial, multicentre, randomised, clinical trial.
    Lancet Respir Med 2017 Feb 14. Epub 2017 Feb 14.
    Institut für anesthesiologische Pathophysiologie und Verfahrensentwicklung, Universitätklinikum Ulm, Ulm, Germany.
    Background: There is insufficient research into the use of mechanical ventilation with increased inspiratory oxygen concentration (FiO2) and fluid resuscitation with hypertonic saline solution in patients with septic shock. We tested whether these interventions are associated with reduced mortality.

    Methods: This two-by-two factorial, multicentre, randomised, clinical trial (HYPERS2S) recruited patients aged 18 years and older with septic shock who were on mechanical ventilation from 22 centres in France. Read More

    Effect of nebulized budesonide on respiratory mechanics and oxygenation in acute lung injury/acute respiratory distress syndrome: Randomized controlled study.
    Saudi J Anaesth 2017 Jan-Mar;11(1):9-14
    Department of Clinical Pathology, Qena University Hospital, South Valley University, Qena, Egypt.
    Background: We tested the hypothesis that nebulized budesonide would improve lung mechanics and oxygenation in patients with early acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS) during protective mechanical ventilation strategy without adversely affecting systemic hemodynamics.

    Methods: Patients with ALI/ARDS were included and assigned into two groups; budesonide group (30 cases) in whom 1 mg-2 ml budesonide suspension was nebulized through the endotracheal tube and control group (30 cases) in whom 2 ml saline (placebo) were nebulized instead of budesonide. This regimen was repeated every 12 h for three successive days alongside with constant ventilator settings in both groups. Read More

    Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism.
    Metabolomics 2016 Aug 26;12(8). Epub 2016 Jul 26.
    McAllister Heart Institute, Department of Pharmacology, Department of Pathology & Laboratory, Medicine, University of North Carolina, Chapel Hill, NC, USA.
    Introduction: Older patients are more likely to acquire and die from acute respiratory distress syndrome (ARDS) and muscle weakness may be more clinically significant in older persons. Recent data implicate muscle ring finger protein 1 (MuRF1) in lung injury-induced skeletal muscle atrophy in young mice and identify an alternative role for MuRF1 in cardiac metabolism regulation through inhibition of fatty acid oxidation.

    Objectives: To develop a model of lung injury-induced muscle wasting in old mice and to evaluate the skeletal muscle metabolomic profile of adult and old acute lung injury (ALI) mice. Read More

    Extracorporeal membrane oxygenation (ECMO) in adults with acute respiratory distress syndrome (ARDS): A 6-year experience and case-control study.
    Heart Lung 2017 Feb 16. Epub 2017 Feb 16.
    ICU, Hospital General Universitario "Gregorio Marañón", Madrid, Spain.
    Purpose: To evaluate the development of an extracorporeal membrane oxygenation (ECMO) program for the treatment of acute respiratory distress syndrome (ARDS) in adults.

    Methods: a) Descriptive study of 15 cases treated since the program approval from 2010 to 2016. b) Case-control study matching the 15 ECMO cases with the 52 severe ARDS treated between 2005 and 2011 in which alternative rescue treatments (prone ventilation, tracheal gas insufflation (TGI) and/or the administration of inhaled nitric oxide (iNO)) were used. Read More

    Some remaining important questions after LUNG SAFE : Discussion of "Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study".
    Intensive Care Med 2017 Feb 17. Epub 2017 Feb 17.
    Department of Anesthesia and Critical Care Medicine, Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, Canada.

    Higher Mini-BAL Total Protein Concentration in Early ARDS Predicts Faster Resolution of Lung Injury Measured by More Ventilator Free Days.
    Am J Physiol Lung Cell Mol Physiol 2017 Feb 17:ajplung.00381.2016. Epub 2017 Feb 17.
    University of California, San Francisco.
    The protein concentration of alveolar edema fluid in acute respiratory distress syndrome (ARDS) is dynamic. It reflects alveolar flooding during acute injury as well as fluid and protein clearance over time. We hypothesized that among ARDS patients treated with low tidal volume ventilation, higher concentrations of protein in mini-bronchoalveolar lavage (mBAL) samples would predict slower resolution of lung injury and worse clinical outcomes. Read More

    How Much Does ICU Structure Account for Variation in Mobility Practices Between Acute Respiratory Distress Syndrome Network Hospitals?
    Crit Care Med 2017 Mar;45(3):e329-e330
    Division of Rehabilitation, Department of Clinical Practice and Support, Hiroshima University Hospital, Minami-ku, Hiroshima, Japan; Department of Intensive Care Medicine, Kameda Medical Center, Kamogawa, Chiba, Japan.

    Skeletal Muscle Weakness Is Associated With Both Early and Late Mortality After Acute Respiratory Distress Syndrome.
    Crit Care Med 2017 Mar;45(3):563-565
    Division of Critical Care Institute of Sports and Exercise Health University College London Hospitals London, UK Division of Pulmonary and Critical Care Medicine University of Michigan Health System; and HSR&D Center for Clinical Management Research VA Ann Arbor Healthcare System Ann Arbor, MI.

    Spontaneous Breathing during Extracorporeal Membrane Oxygenation in Acute Respiratory Failure.
    Anesthesiology 2017 Feb 17. Epub 2017 Feb 17.
    From the Dipartimento di Anestesia, Rianimazione ed Emergenza Urgenza, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy (S.C., N.B., E.S., D.T., A.L., A.P.); and Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, and Università degli Studi di Milano, Milan, Italy (G.M.R.); and Department of Anesthesia and Intensive Care, Georg-August-Universität, Göttingen, Germany (L.G.). The work was performed at the Intensive Care Unit "E.Vecla," Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy.
    Background: We evaluate the clinical feasibility of spontaneous breathing on extracorporeal membrane oxygenation and the interactions between artificial and native lungs in patients bridged to lung transplant or with acute exacerbation of chronic obstructive pulmonary disease (COPD) or acute respiratory distress syndrome.

    Methods: The clinical course of a total of 48 patients was analyzed. Twenty-three of 48 patients were enrolled in the prospective study (nine bridged to lung transplant, six COPD, and eight acute respiratory distress syndrome). Read More

    Simulation of Healing Threshold in Strain-Induced Inflammation through a Discrete Informatics Model.
    IEEE J Biomed Health Inform 2017 Feb 15. Epub 2017 Feb 15.
    Respiratory diseases such as asthma and acute respiratory distress syndrome as well as acute lung injury involve inflammation at the cellular level. The inflammation process is very complex and is characterized by the emergence of cytokines along with other changes in cellular processes. Due to the complexity of the various constituents that makes up the inflammation dynamics, it is necessary to develop models that can complement experiments to fully understand inflammatory diseases. Read More

    Pneumonia, Acute Respiratory Distress Syndrome, and Early Immune-Modulator Therapy.
    Int J Mol Sci 2017 Feb 11;18(2). Epub 2017 Feb 11.
    Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
    Acute respiratory distress syndrome (ARDS) is caused by infectious insults, such as pneumonia from various pathogens or related to other noninfectious events. Clinical and histopathologic characteristics are similar across severely affected patients, suggesting that a common mode of immune reaction may be involved in the immunopathogenesis of ARDS. There may be etiologic substances that have an affinity for respiratory cells and induce lung cell injury in cases of ARDS. Read More

    Preventive Effects of Carnosine on Lipopolysaccharide-induced Lung Injury.
    Sci Rep 2017 Feb 16;7:42813. Epub 2017 Feb 16.
    Laboratory of Bio-Analytical Chemistry, Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo-shi, Tokyo 202-8585, Japan.
    Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute lung injury, which involves neutrophilic inflammation and pulmonary cell death. Reactive oxygen species (ROS) play important roles in ARDS development. New compounds for inhibiting the onset and progression of ARDS are required. Read More

    Acute respiratory distress syndrome and chemical burns after exposure to chlorine-containing bleach: a case report.
    J Thorac Dis 2017 Jan;9(1):E17-E20
    Department of Internal Medicine, Chonnam National University Hospital, Gwangju, South Korea.
    Chlorine-containing bleach can cause acute respiratory distress syndrome (ARDS) and chemical burns. However, simultaneous occurrence of the two conditions caused by this agent is very rare. We describe the case of a 74-year-old female who presented with shortness of breath and hemoptysis following accidental exposure to chlorine-containing bleach. Read More

    DNA Repair Interacts with Autophagy To Regulate Inflammatory Responses to Pulmonary Hyperoxia.
    J Immunol 2017 Feb 15. Epub 2017 Feb 15.
    Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203;
    Oxygen is supplied as a supportive treatment for patients suffering from acute respiratory distress syndrome. Unfortunately, high oxygen concentration increases reactive oxygen species generation, which causes DNA damage and ultimately cell death in the lung. Although 8-oxoguanine-DNA glycosylase (OGG-1) is involved in repairing hyperoxia-mediated DNA damage, the underlying molecular mechanism remains elusive. Read More

    Association between chronic exposure to air pollution and mortality in the acute respiratory distress syndrome.
    Environ Pollut 2017 Feb 12. Epub 2017 Feb 12.
    Division of Critical Care Medicine, St. Paul's Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada; Centre for Heart Lung Innovation (HLI), University of British Columbia, Vancouver, Canada. Electronic address:
    The impact of chronic exposure to air pollution and outcomes in the acute respiratory distress syndrome (ARDS) is unknown. The Nationwide Inpatient Sample (NIS) from 2011 was utilized for this analysis. The NIS is a national database that captures 20% of all US in-patient hospitalizations from 47 states. Read More

    [Risk factors for poor prognosis in children with severe adenovirus pneumonia].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Feb;19(2):159-162
    Deparment of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
    Objective: To investigate the risk factors for poor prognosis of severe adenovirus pneumonia (SAP) in children.

    Methods: The clinical data of 189 children with SAP were retrospectively analyzed. Univariate logistic regression analysis was performed to assess the risk factors for poor prognosis. Read More

    Mitochondrial DNA-Induced Inflammatory Responses and Lung Injury in Thermal Injury Rat Model: Protective Effect of Epigallocatechin Gallate.
    J Burn Care Res 2017 Feb 6. Epub 2017 Feb 6.
    From the *Department of Burns and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, People's Republic of China; †Department of Anesthesiology, Chengdu Women and Children's Central Hospital, People's Republic of China; and ‡West China School of Medicine, Sichuan University, Chengdu, People's Republic of China.
    Lungs are easily damaged by the inflammatory responses induced after extensive burns. The aim here was to investigate the protective role of epigallocatechin gallate (EGCG) in mitochondrial DNA (mtDNA)-mediated inflammatory responses and acute respiratory distress syndrome (ARDS) in a rat model of thermal injury. Male Sprague-Dawley rats were randomly assigned to five groups. Read More

    The effect of demographics and patient location on the outcome of patients with acute respiratory distress syndrome.
    Ann Thorac Med 2017 Jan-Mar;12(1):17-24
    Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, MI, USA.
    Objective: Outcome of acute respiratory distress syndrome (ARDS) in relation to age, gender, race, pre-Intensive Care Unit (ICU) location, and type of ICU.

    Methods: Retrospective cohort study of patients enrolled in the ARDS network randomized controlled trials.

    Results: A total of 2914 patients were included in these trials. Read More

    Extracorporeal membrane oxygenation for avian influenza A (H7N9) patient with acute respiratory distress syndrome: a case report and short literature review.
    BMC Pulm Med 2017 Feb 14;17(1):38. Epub 2017 Feb 14.
    Wuhan Medical Treatment Center, Yintan Road NO.1, Wuhan, 430023, Hu Bei, China.
    Background: Extracorporeal membrane oxygenation (ECMO) is performed as an acceptable life-saving bridging procedure in patients with severe acute respiratory distress syndrome (ARDS).To patients with avian influenza A (H7N9)-associated ARDS, ECMO could be adopted as a feasible therapeutic solution. We present our successful experience with ECMO utilized in a respiratory failure patient with H7N9 infection. Read More

    Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome.
    PLoS One 2017 14;12(2):e0172116. Epub 2017 Feb 14.
    Department of Pediatrics, University of Colorado at Denver, Aurora, Colorado, United States of America.
    A hallmark of acute respiratory distress syndrome (ARDS) is accumulation of protein-rich edema in the distal airspaces and its removal is critical for patient survival. Previous studies have shown a detrimental role of Glycogen Synthase Kinase (GSK) 3β during ARDS via inhibition of alveolar epithelial protein transport. We hypothesized that post-transcriptional regulation of GSK3β could play a functional role in ARDS resolution. Read More

    Effects of budesonide on the lung functions, inflammation and apoptosis in a saline-lavage model of acute lung injury.
    J Physiol Pharmacol 2016 Dec;67(6):919-932
    Biomedical Center Martin and Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
    Diffuse alveolar injury, edema, and inflammation are fundamental signs of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Whereas the systemic administration of corticosteroids previously led to controversial results, this study evaluated if corticosteroids given intratracheally may improve lung functions and reduce edema formation, migration of cells into the lung and their activation in experimentally-induced ALI. In oxygen-ventilated rabbits, ALI was induced by repetitive saline lung lavage, until PaO2 decreased to < 26. Read More

    Scrotal Abscess: A Rare Presentation of Complicated Necrotizing Pancreatitis.
    Arch Iran Med 2017 Feb;20(2):124-127
    Researcher Associate of Clinical Research Development Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Acute pancreatitis is characterized by activation of digestive enzymes inside the pancreas. In severe pancreatitis, necrosis of pancreas and surrounding tissues may occur. Acute necrotizing pancreatitis commonly presents as pancreatic abscess occasionally with systemic complications. Read More

    Inadvertent Skipping of Steroids in Septic Shock Leads to a Diagnosis of Adult Onset Still's Disease.
    Cureus 2017 Jan 14;9(1):e978. Epub 2017 Jan 14.
    Department of General Medicine, Indira Gandhi Medical College & Research Institute, Pondicherry, India.
    Adult onset Still's disease is uncommon in middle-aged and elderly individuals and can rarely present with shock; shock is usually associated with disseminated intravascular coagulation, multiorgan dysfunction syndrome or acute respiratory distress syndrome. We report a post-menopausal woman with arthritis, fever, pneumonitis and hypotension which was managed as septic shock. Steroids were inadvertently missed during the second day of hospitalization in the intensive care unit. Read More

    Venovenous Versus Venoarterial Extracorporeal Membrane Oxygenation for Adult Patients With Acute Respiratory Distress Syndrome Requiring Precannulation Hemodynamic Support: A Review of the ELSO Registry.
    Ann Thorac Surg 2017 Feb 9. Epub 2017 Feb 9.
    Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
    Background: In addition to severe hypoxia and hypercapnia, acute respiratory distress syndrome (ARDS) can present with substantial hemodynamic compromise, requiring inotropic or vasopressor support or both. Either venovenous (VV) or venoarterial (VA) extracorporeal membrane oxygenation (ECMO) can be offered in this situation. However, a contemporary comparison of these two cannulation strategies has yet to be well described. Read More

    H7N9 Influenza A Virus Exhibits Importin-α7-Mediated Replication in the Mammalian Respiratory Tract.
    Am J Pathol 2017 Feb 8. Epub 2017 Feb 8.
    Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany; Center for Structural and Cellular Biology in Medicine, University of Lübeck, Lübeck, Germany. Electronic address:
    The acute respiratory distress syndrome (ARDS) is the leading cause of death in influenza A virus (IAV)-infected patients. Hereby, the cellular importin-α7 gene plays a major role. It promotes viral replication in the lung, thereby increasing the risk for the development of pneumonia complicated by ARDS. Read More

    Inflammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGFβ-driven pulmonary vascular remodeling.
    Am J Physiol Lung Cell Mol Physiol 2017 Feb 10:ajplung.00484.2016. Epub 2017 Feb 10.
    University of Illinois
    Endothelial cell (EC) activation and vascular injury are hallmark features of Acute Lung Injury and Acute Respiratory Distress Syndrome (ALI/ARDS). Caveolin-1 (Cav-1) is highly expressed in pulmonary microvascular ECs and plays a key role in maintaining vascular homeostasis. The aim of this study was to determine whether the lung inflammatory response to Escherichia coli lipopolysaccharide (LPS) promotes priming of ECs via Cav-1 depletion and whether this contributes to the onset of pulmonary vascular remodeling. Read More

    Mechanical ventilation in patients subjected to extracorporeal membrane oxygenation (ECMO).
    Med Intensiva 2017 Feb 7. Epub 2017 Feb 7.
    Servicio de Medicina Intensiva, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, España. Electronic address:
    Mechanical ventilation (MV) is a crucial element in the management of acute respiratory distress syndrome (ARDS), because there is high level evidence that a low tidal volume of 6ml/kg (protective ventilation) improves survival. In these patients with refractory respiratory insufficiency, venovenous extracorporeal membrane oxygenation (ECMO) can be used. This salvage technique improves oxygenation, promotes CO2 clearance, and facilitates protective and ultraprotective MV, potentially minimizing ventilation-induced lung injury. Read More

    Neuropulmonology.
    Handb Clin Neurol 2017 ;140:33-48
    Department of Anesthesiology, University of Rochester Medical Center, Rochester, NY, USA; Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA; Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA; Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY, USA. Electronic address:
    Neuropulmonology refers to the complex interconnection between the central nervous system and the respiratory system. Neurologic injury includes traumatic brain injury, hemorrhage, stroke, and seizures, and in each there are far-reaching effects that can result in pulmonary dysfunction. Systemic changes can induce impairment of pulmonary function due to changes in the core structure and function of the lung. Read More

    Plasma Neutrophil Elastase and Elafin as Prognostic Biomarker for Acute Respiratory Distress Syndrome: A Multicenter Survival and Longitudinal Prospective Observation Study.
    Shock 2017 Feb 9. Epub 2017 Feb 9.
    *Department of Critical Care Medicine, Peking University Third Hospital, Beijing, China †Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA ‡Intensive Care Unit, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China §Intensive Care Unit, Xiyuan Hospital Affiliated to China Academy of Chinese Medical Sciences, Beijing, China ¶Intensive Care Unit, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing, China ||Intensive Care Unit, China-Japan Friendship Hospital, Beijing, China **Division of Pulmonary, Allergy and Critical Care, Emory University School of Medicine.
    Background: Neutrophil elastase (HNE) is a destructive enzyme and plays crucial roles in the pathophysiology of acute respiratory distress syndrome (ARDS). Endogenous proteinase inhibitors elafin (PI3) is important to protect against lung tissue destruction. We proposed to examine whether HNE and PI3 serve as prognostic biomarkers for ARDS. Read More

    Concise Review: Mesenchymal Stromal Cell-Based Approaches for the Treatment of Acute Respiratory Distress and Sepsis Syndromes.
    Stem Cells Transl Med 2017 Jan 9. Epub 2017 Jan 9.
    Department of Surgery, University Hospital Regensburg, Regensburg, Germany.
    Despite extensive research on candidate pharmacological treatments and a significant and increasing prevalence, sepsis syndrome, and acute respiratory distress syndrome (ARDS) remain areas of unmet clinical need. Preclinical studies examining mesenchymal stromal cell (MSCs) based-therapies have provided compelling evidence of potential benefit; however, the precise mechanism by which MSCs exert a therapeutic influence, and whether MSC application is efficacious in humans, remains unknown. Detailed evaluation of the limited number of human trials so far completed is further hampered as a result of variations in trial design and biomarker selection. Read More

    Adjuvant rituximab treatment for pemphigus: A retrospective study of 45 patients at a single center with long-term follow up.
    J Dermatol 2017 Feb 10. Epub 2017 Feb 10.
    Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
    To evaluate the long-term outcomes of rituximab in the treatment of pemphigus and the influence of disease duration and different dose of rituximab on the clinical response, 45 patients with refractory pemphigus treated with at least one cycle of two infusions of rituximab (375 mg/m(2) per infusion weekly) were retrospectively studied. All patients were followed up for more than 2 years. All patients achieved complete or partial remission within 8 months of the first cycle. Read More

    Extracorporeal Membrane Oxygenation Outcomes in Acute Respiratory Distress Treatment: Case Study in a Chinese Referral Center.
    Med Sci Monit 2017 Feb 10;23:741-750. Epub 2017 Feb 10.
    Department of Heart Center, Tianjin third central hospital, Tianjin, China (mainland).
    BACKGROUND No definitive conclusions have been drawn from the available data about the utilization of extracorporeal membrane oxygenation (ECMO) to treat severe acute respiratory distress syndrome (ARDS). The aim of this study was to review our center's experience with ECMO and determine predictors of outcome from our Chinese center. MATERIAL AND METHODS We retrospectively analyzed a total of 23 consecutive candidates who fulfilled the study entry criteria between January 2009 and December 2015. Read More

    Swine influenza A (H1N1) virus (SIV) infection requiring extracorporeal life support in an immunocompetent adult patient with indirect exposure to pigs, Italy, October 2016.
    Euro Surveill 2017 Feb;22(5)
    SS Virologia Molecolare, SC Microbiologia e Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
    We describe a case of severe swine influenza A(H1N1) virus infection in an immunocompetent middle-aged man in October 2016 in Italy who had only indirect exposure to pigs. The patient developed a severe acute distress respiratory syndrome which was successfully supported by extracorporeal membrane oxygenation and treated with antiviral therapy. The sole risk factor for influenza was a body mass index > 30 kg/m(2). Read More

    Acute Respiratory Distress Syndrome after Viscum album Pleurodesis for Primary Spontaneous Pneumothorax.
    Korean J Thorac Cardiovasc Surg 2017 Feb 5;50(1):64-67. Epub 2017 Feb 5.
    Department of Thoracic and Cardiovascular Surgery, CHA Bundang Medical Center, CHA University.
    A 52-year-old male patient who underwent multiple wedge resections experienced postoperative acute respiratory distress syndrome in both lungs after Viscum album pleurodesis. Despite initial rapid deterioration in clinical condition and rapid progression of bilateral lung infiltration, he exhibited a relatively smooth clinical recovery with marked response to glucocorticoid treatment. Our case report suggests that care must be taken to guard against the development of acute respiratory complications in the use of Viscum album for pleurodesis. Read More

    Interhospital Transport System for Critically Ill Patients: Mobile Extracorporeal Membrane Oxygenation without a Ventilator.
    Korean J Thorac Cardiovasc Surg 2017 Feb 5;50(1):8-13. Epub 2017 Feb 5.
    Department of Thoracic and Cardiovascular Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital.
    Background: Extracorporeal membrane oxygenation (ECMO) has been successfully used as a method for the interhospital transportation of critically ill patients. In South Korea, a well-established ECMO interhospital transport system is lacking due to limited resources. We developed a simplified ECMO transport system without mechanical ventilation for use by public emergency medical services. Read More

    Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome.
    BMC Pulm Med 2017 Feb 8;17(1):34. Epub 2017 Feb 8.
    School of Engineering, University of Warwick, Nottingham, CV4 7AL, UK.
    Background: Clinical trials have, so far, failed to establish clear beneficial outcomes of recruitment maneuvers (RMs) on patient mortality in acute respiratory distress syndrome (ARDS), and the effects of RMs on the cardiovascular system remain poorly understood.

    Methods: A computational model with highly integrated pulmonary and cardiovascular systems was configured to replicate static and dynamic cardio-pulmonary data from clinical trials. Recruitment maneuvers (RMs) were executed in 23 individual in-silico patients with varying levels of ARDS severity and initial cardiac output. Read More

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