56,897 results match your criteria Acute Respiratory Distress Syndrome

Obstetrics outcome in pulmonary tuberculosis.

Indian J Tuberc 2022 Jul 7;69(3):305-310. Epub 2021 Jan 7.

Department of Obstetrics and Gynecology, AIIMS, New Delhi, India.

Background: To evaluate the maternal and perinatal outcome in pulmonary tuberculosis cases as compared to low risk pregnancies in a tertiary referral hospital.

Methods: A total of 15 cases of pulmonary tuberculosis over a period of two years who delivered in our unit was studied in the retrospective study. The maternal and perinatal outcome in them was compared with 191 low risk pregnancies who delivered at the same time in the hospital after taking into account inclusion and exclusion criteria. Read More

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Mechanical Ventilation during ECMO: Lessons from Clinical Trials and Future Prospects.

Semin Respir Crit Care Med 2022 Jun 27. Epub 2022 Jun 27.

Critical Care Research Group, The Prince Charles Hospital, Brisbane, QLD, Australia.

Acute Respiratory Distress Syndrome (ARDS) accounts for 10% of ICU admissions and affects 3 million patients each year. Despite decades of research, it is still associated with one of the highest mortality rates in the critically ill. Advances in supportive care, innovations in technologies and insights from recent clinical trials have contributed to improved outcomes and a renewed interest in the scope and use of Extracorporeal life support (ECLS) as a treatment for severe ARDS, including high flow veno-venous Extracorporeal Membrane Oxygenation (VV-ECMO) and low flow Extracorporeal Carbon Dioxide Removal (ECCO2R). Read More

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[Clinical characteristics related to mortality by COVID-19 in intensive care].

Rev Med Inst Mex Seguro Soc 2022 May 2;60(3):249-257. Epub 2022 May 2.

Instituto Mexicano del Seguro Social, Hospital General Regional No. 66, Servicio de Urgencias. Ciudad Juárez, Chihuahua, México.

Background: The COVID-19 pandemic caused hospital reconversion throughout Mexico and it was scarce information about its development in second-level intensive care units (ICU).

Objective: To determine the clinical characteristics related to COVID-19 mortality in a second-level ICU.

Material And Methods: Observational, cohort, retrospective, and analytical study. Read More

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Bilateral Emphysematous Pyelonephritis Associated with COVID Pneumonia: A Case Report.

Am J Case Rep 2022 Jun 27;23:e936370. Epub 2022 Jun 27.

Department of Urology, Euromedik, Belgrade, Serbia.

BACKGROUND 0ptviral pneumonia and bilateral emphysematous pyelonephritis create a rapid acute respiratory distress syndrome. CASE REPORT A 59-year-old diabetic man with altered awareness was admitted as an emergency due to fever, shivering, and pain in the lap. Based on the accurate diagnosis, we concluded that the patient had bilateral emphysematous pyelonephritis, as well as inflammatory changes in the lung parenchyma caused by coronavirus infection (SARS-CoV-2). Read More

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A Limited Role for AMD3100 Induced Stem Cell Mobilization for Modulation of Thoracic Trauma Outcome.

Shock 2022 Jun;57(6):260-267

Institute of Molecular Medicine, Ulm University, Ulm, Germany.

Abstract: Thoracic trauma is a major cause of mortality due to the associated inflammatory acute respiratory distress syndrome and morbidity due to impaired tissue regeneration. Trauma-induced lung inflammation is characterized by the early recruitment of cells with pro- or anti-inflammatory activity to the lung. Therapeutic interventions reducing the level of tissue inflammation may result in decreased tissue damage and improved healing and recovery. Read More

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Updated Living Systematic Review and Meta-analysis of Controlled Trials of Mesenchymal Stromal Cells to Treat COVID-19: A Framework for Accelerated Synthesis of Trial Evidence for Rapid Approval-FASTER Approval.

Stem Cells Transl Med 2022 Jun 27. Epub 2022 Jun 27.

Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.

Background: Mesenchymal stromal cells (MSCs) may reduce mortality in patients with COVID-19; however, early evidence is based on few studies with marked interstudy heterogeneity. The second iteration of our living systematic review and meta-analysis evaluates a framework needed for synthesizing evidence from high-quality studies to accelerate consideration for approval.

Methods: A systematic search of the literature was conducted on November 15, 2021, to identify all English-language, full-text, and controlled clinical studies examining MSCs to treat COVID-19 (PROSPERO: CRD42021225431). Read More

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Neutrophil Extracellular Traps, Sepsis and COVID-19 - A Tripod Stand.

Front Immunol 2022 10;13:902206. Epub 2022 Jun 10.

Department of Biology, State University of New York at Fredonia, Fredonia, NY, United States.

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic. Majority of COVID-19 patients have mild disease but about 20% of COVID-19 patients progress to severe disease. These patients end up in the intensive care unit (ICU) with clinical manifestations of acute respiratory distress syndrome (ARDS) and sepsis. Read More

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Human Placental Mesenchymal Stem Cells for the Treatment of ARDS in Rat.

Stem Cells Int 2022 22;2022:8418509. Epub 2022 Jun 22.

Department of Clinical Anatomy, Tbilisi State Medical University, Tbilisi 0186, Georgia.

The acute respiratory distress syndrome (ARDS) is one of the main causes of high mortality in patients with coronavirus (COVID-19). In recent years, due to the coronavirus pandemic, the number of patients with ARDS has increased significantly. Unfortunately, until now, there are no effective treatments for ARDS caused by COVID-19. Read More

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The kidney in hantavirus infection-epidemiology, virology, pathophysiology, clinical presentation, diagnosis and management.

Clin Kidney J 2022 Jul 29;15(7):1231-1252. Epub 2022 Jan 29.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Hantavirus-induced diseases are emerging zoonoses with endemic appearances and frequent outbreaks in different parts of the world. In humans, hantaviral pathology is characterized by the disruption of the endothelial cell barrier followed by increased capillary permeability, thrombocytopenia due to platelet activation/depletion and an overactive immune response. Genetic vulnerability due to certain human leukocyte antigen haplotypes is associated with disease severity. Read More

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A Pilot Study on COVID-19 Positive Subjects: An Excerpt of Post-Infection-Pro-Diabetic Disposition & Related Consequences in Correlation to Hepato-Pancreatic Bio-Markers, Pro-Inflammatory Cytokines and Other Risk Factors.

Indian J Clin Biochem 2022 Jun 18:1-11. Epub 2022 Jun 18.

Department of Biochemistry, All India Institute of Medical Sciences, Patna, 801507 India.

COVID-19, a global pandemic that led to increased morbidity and mortality worldwide since its outcome at the end of the year 2019. A newly discovered variant of severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2) was the arbitrator for spreading the syndrome by droplet transmission causing multi-organ failure in many occasions. A post-infection-pro-diabetic disposition was found evident in this study with the persistence of hepato-pancreatic aberrations in respect of reference range of tissue specific bio-markers in hospital admitted COVID-19 cases. Read More

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Unusual Cause of Respiratory Distress in a Term Neonate.

Ochsner J 2022 ;22(2):196-198

Department of Pediatrics, Ochsner Louisiana State University Health-Shreveport, Shreveport, LA.

Respiratory distress is a clinical finding often seen in neonates. Common causes of respiratory distress in this population include respiratory distress syndrome, transient tachypnea of the newborn, infection, aspiration, and cardiac etiologies. We present the case of a neonate who presented with respiratory distress with no identifiable cause on initial workup. Read More

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January 2022

Epidemiology, Clinico-Pathological Characteristics, and Comorbidities of SARS-CoV-2-Infected Pakistani Patients.

Front Cell Infect Microbiol 2022 26;12:800511. Epub 2022 May 26.

Department of Immunology, University of Health Sciences, Lahore, Pakistan.

SARS-CoV-2 is a causative agent for COVID-19 disease, initially reported from Wuhan, China. The infected patients experienced mild to severe symptoms, resulting in several fatalities due to a weak understanding of its pathogenesis, which is the same even to date. This cross-sectional study has been designed on 452 symptomatic mild-to-moderate and severe/critical patients to understand the epidemiology and clinical characteristics of COVID-19 patients with their comorbidities and response to treatment. Read More

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Case Report: The Experience of Managing a Moderate ARDS Caused by SARS-CoV-2 Omicron BA.2 Variant in Chongqing, China: Can We Do Better?

Front Med (Lausanne) 2022 9;9:921135. Epub 2022 Jun 9.

Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: The severe coronavirus disease 2019 (COVID-19) pandemic is still raging worldwide, and the Omicron BA.2 variant has become the new circulating epidemic strain. However, our understanding of the Omicron BA. Read More

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Local Anesthetic Systemic Toxicity After Local Infiltration Analgesia Following a Total Knee Arthroplasty.

Cureus 2022 Jun 23;14(6):e26224. Epub 2022 Jun 23.

Anesthesiology and Reanimation, Centre Hospitalier Intercommunal Nord-Ardenne Charleville-Mézières, Charleville-Mézières, FRA.

Multimodal analgesia is nowadays a recognized method to reduce postoperative pain. Infiltration of the surgical site with local anesthetic is one of the methods widely used for its effectiveness and its lower risk of toxicity, particularly in orthopedic surgery. We present here a case of local anesthetic systemic toxicity (LAST) that occurred on two different occasions to the same patient after total knee replacement surgeries. Read More

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Over-transfusion with blood for suspected hemorrhagic shock is not associated with worse clinical outcomes.

Transfusion 2022 Jun 26. Epub 2022 Jun 26.

Department of Trauma and Acute Care Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Background: We evaluated patient outcomes after early, small volume red blood cell (RBC) transfusion in the setting of presumed hemorrhagic shock. We hypothesized that transfusion with even small amounts of blood would be associated with more complications.

Study Design And Methods: Retrospective review of trauma patients admitted to a Level 1 trauma center between 2016-2021. Read More

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Safety, efficacy and biomarkers analysis of mesenchymal stromal cells therapy in ARDS: a systematic review and meta-analysis based on phase I and II RCTs.

Stem Cell Res Ther 2022 Jun 25;13(1):275. Epub 2022 Jun 25.

Department of Respiratory and Critical Care Medicine, Fujian Respiratory Medical Center, The Second Affiliated Hospital of Fujian Medical University, Quanzhou City, Fujian Province, China.

Background: Mesenchymal stromal cells (MSCs) therapy for acute respiratory distress syndrome (ARDS) is an emerging treatment, but most of the current trials of MSCs stay in the animal experimental stage, and the safety and efficacy of MSCs in clinical application are not clear. We aimed to analyze the safety, efficacy and biomarkers of mesenchymal stromal cells in the treatment of ARDS.

Methods: For this systematic review and meta-analysis, we searched PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of science, CNKI, VIP and Wan Fang data, studies published between database inception and Mar 17, 2022. Read More

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Retraction Note to: Targeting MALAT1 and miRNA-181a-5p for the intervention of acute lung injury/acute respiratory distress syndrome.

Respir Res 2022 Jun 25;23(1):170. Epub 2022 Jun 25.

Department of Anesthesiology, The Second Afliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, 215004, Jiangsu, China.

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Effects of transthoracic echocardiography on the prognosis of patients with acute respiratory distress syndrome: a propensity score matched analysis of the MIMIC-III database.

BMC Pulm Med 2022 Jun 25;22(1):247. Epub 2022 Jun 25.

Department of ICU, Shaanxi Provincial People's Hospital, No. 256, Youyi West Road, Beilin District, Xi'an, Shaanxi, China.

Background: Acute respiratory distress syndrome (ARDS) has high mortality and is mainly related to the circulatory failure.Therefore, real-time monitoring of cardiac function and structural changes has important clinical significance.Transthoracic echocardiography (TTE) is a simple and noninvasive real-time cardiac examination which is widely used in intensive care unit (ICU) patients. Read More

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ISM1 suppresses LPS-induced acute lung injury and post-injury lung fibrosis in mice.

Mol Med 2022 Jun 25;28(1):72. Epub 2022 Jun 25.

Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, 117543, Republic of Singapore.

Background: Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) are clinical syndromes characterized by acute lung inflammation, pulmonary edema and hypoxemia, with up to 50% mortality rate without effective pharmacological therapy. Following the acute inflammation, repair and remodeling occurs which in some cases resulting in lung fibrosis. The pathophysiology of ALI/ARDS remains incompletely understood. Read More

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The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19.

Inflamm Res 2022 Jun 25. Epub 2022 Jun 25.

Department of Health Information Management, School of Medicine and Allied Medical Sciences, Ardabil University of Medical Sciences, Ardabil, Iran.

A global pandemic has erupted as a result of the new brand coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic has been consociated with widespread mortality worldwide. The antiviral immune response is an imperative factor in confronting the recent coronavirus disease 2019 (COVID-19) infections. Read More

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Diagnostic challenge of Strongyloides stercoralis hyperinfection syndrome: a case report.

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):79-81

Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Strongyloides stercoralis causes chronic, mostly asymptomatic infections but hyperinfection syndrome may occur in immunosuppressed patients, especially in those receiving corticosteroids. We report a case of S. stercoralis hyperinfection syndrome in a solid organ transplant recipient that occurred approximately 2. Read More

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Black fungus: A rising consternation among COVID patients presenting to a tertiary care hospital in Islamabad-Pakistan Institute of Medical Sciences.

J Pak Med Assoc 2022 Jun;72(6):1225-1228

Department of Head and Neck, Pakistan Institute of Medical Sciences,Islamabad, Pakistan.

For almost one and a half year the world is facing the pandemic called COVID-19, which is an acute respiratory distress syndrome caused by coronavirus 2 (SARS-CoV2). This disease has already engulfed many lives and has not been tamed so far. Physicians all over the world still, trying to get a hold of this global health issue, are faced with another life-threatening challenge associated with COVID-19, called black fungus-Mucormycosis. Read More

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COVID-19 outcomes in patients with Dermatomyositis: A registry-based cohort analysis.

Semin Arthritis Rheum 2022 May 28;56:152034. Epub 2022 May 28.

Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI), Lucknow, Uttar Pradesh, India; Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK; Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, The University of Manchester, Manchester, UK.; City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK. Electronic address:

Background: Patients with rheumatic diseases (RDs) like DM are known to be vulnerable towards various types of infections due to aggressive disease activity mandating high dose immunosuppressive therapy. The severity of COVID-19 in RDs is limited in literature due to the heterogeneous nature of the condition. Therefore, specific details on mortality is essential to navigate any precautions required in the treatment. Read More

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Initiation of Inhaled Nitric Oxide by an Air Transport Team in Adult Coronavirus Disease 2019 Respiratory Failure.

Air Med J 2022 Jul-Aug;41(4):406-410. Epub 2022 Mar 10.

BerbeeWalsh University of Wisconsin Department of Emergency Medicine, Madison, WI; University of Wisconsin MedFlight, BerbeeWalsh Department of Emergency Medicine, Madison, WI.

The coronavirus disease 2019 (COVID-19) pandemic has caused a significant increase in the volume of critical care flight transports between outlying referral hospitals and tertiary care facilities. Because of the tropism of severe acute respiratory syndrome coronavirus 2, flight crews are often asked to transport mechanically ventilated patients in refractory hypoxemic respiratory failure. The authors present a case series of 5 patients with COVID-19 acute respiratory distress syndrome (ARDS) who were initiated on inhaled nitric oxide (iNO) by the transport team before rotor wing transport and survived the journey in stable or improved condition upon arrival. Read More

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Intubation Rate Evaluation of Inborn Versus Outborn Premature Newborns Affected by Respiratory Distress Syndrome: Impact of Neonatal Transport.

Air Med J 2022 Jul-Aug;41(4):346-349. Epub 2022 May 28.

Neonatal Intensive Care Unit, Neonatal Emergency Transport Service, Department Mother and Child, Istituto di Ricovero e Cura a Carattere Scientifico Gaslini Hospital, Genoa, Italy. Electronic address:

Objective: The aim of this study was to compare the management of preterm newborns with respiratory distress both in the delivery room and during transportation.

Methods: We retrospectively evaluated the intubation rate in preterm newborns (inborn vs. outborn), gestational age (GA) < 34 weeks, admitted to the Gaslini neonatal intensive care unit, Genoa, Italy (January 2019-December 2020). Read More

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Rare cause of diffuse alveolar haemorrhage and subconjunctival haemorrhage rescued by extracorporeal membrane oxygenation and rituximab.

BMJ Case Rep 2022 Jun 24;15(6). Epub 2022 Jun 24.

Department of Rheumatology, Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

A previously healthy man in his 20s presented with acute respiratory distress syndrome and subconjunctival haemorrhage. Imaging was indicative of pervasive pulmonary haemorrhage. There was no evidence of renal involvement. Read More

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Development of the Sepsis-Associated Adverse Outcomes in Pregnancy Score.

Am J Perinatol 2022 Jun 24. Epub 2022 Jun 24.

Obstetrics & Gynecology, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, United States.

Objective: To develop and evaluate a scoring system-called Sepsis-Associated Adverse Outcomes in Pregnancy (SAAP) Score-to identify individuals with maternal infection that have composite maternal adverse outcomes (CMAO).

Study Design: Using ICD codes, we identified pregnant and postpartum (up to 6 weeks after birth) individuals admitted at our center with a primary diagnosis of infection. The primary outcome was CMAO, which included any of the following: maternal intensive care unit admission, surgical intervention, vasopressor use, acute respiratory distress syndrome, pulmonary edema, mechanical ventilation, high flow nasal cannula, disseminated intravascular coagulation, dialysis, organ failure, venous thromboembolism, or maternal death. Read More

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Impact of hypertensive disorders of pregnancy on respiratory outcomes in extremely and very preterm infants: A population-based study in Japan.

Pregnancy Hypertens 2022 Jun 17;29:54-60. Epub 2022 Jun 17.

Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Division of Perinatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, Japan.

Objectives: We aimed to evaluate the impact of hypertensive disorders of pregnancy (HDP) on short- and medium-term respiratory outcomes in extremely and very preterm infants using the Neonatal Research Network of Japan database.

Study Design: This was a population-based retrospective study of preterm infants weighing ≤ 1500 g born between 22 and 31 weeks of gestation between 2003 and 2017. After 1:1 stratification matching by four factors (maternal age, gestational age, parity, and year of delivery), a total of 5137 infants in each group (HDP and non-HDP groups) were selected. Read More

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Risk factors associated with in-hospital mortality patients with COVID-19 in Saudi Arabia.

PLoS One 2022 24;17(6):e0270062. Epub 2022 Jun 24.

Department of Pharmacy Services, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.

Risk factors for in-hospital mortality of COVID-19 patients in Saudi Arabia have not been well studied. Previous reports from other countries have highlighted the effect of age, gender, clinical presentation and health conditions on the outcome of COVID-19 patients. Saudi Arabia has a different epidemiological structure with a predominance of young population, which calls for separate study. Read More

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Human gingival mesenchymal stem cells retain their growth and immunomodulatory characteristics independent of donor age.

Sci Adv 2022 Jun 24;8(25):eabm6504. Epub 2022 Jun 24.

Institute of Bioinformatics and Biotechnology, Savitribai Phule Pune University, Pune, 411007 Maharashtra, India.

Aging has been reported to deteriorate the quantity and quality of mesenchymal stem cells (MSCs), which affect their therapeutic use in regenerative medicine. A dearth of age-related stem cell research further restricts their clinical applications. The present study explores the possibility of using MSCs derived from human gingival tissues (GMSCs) for studying their ex vivo growth characteristics and differentiation potential with respect to donor age. Read More

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