99,829 results match your criteria Acute Renal Failure


Insulin-like growth factor binding protein 7 promotes acute kidney injury by alleviating poly ADP ribose polymerase 1 degradation.

Kidney Int 2022 Jun 22. Epub 2022 Jun 22.

Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the Key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, China. Electronic address:

The novel biomarker, insulin-like growth factor binding protein 7 (IGFBP7), is used clinically to predict different types of acute kidney injury (AKI) and has drawn significant attention as a urinary biomarker. However, as a secreted protein in the circulation of patients with AKI, it is unclear whether IGFBP7 acts as a key regulator in AKI progression, and if mechanisms underlying its upregulation still need to be determined. Here we found that IGFBP7 is highly expressed in the blood and urine of patients and mice with AKI possibly via a c-Jun-dependent mechanism, and is positively correlated with kidney dysfunction. Read More

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Early Diagnostic Value of Urinary NGAL in Acute Kidney Injury in Septic Patients.

Altern Ther Health Med 2022 Jun 24. Epub 2022 Jun 24.

Background: The aim of this study was to evaluate the predictive value of urinary neutrophil gelatinase-associated lipid (uNGAL) for the prediction of sepsis-associated acute kidney injury (SA-AKI).

Methods: From September to December 2012, 110 patients were prospectively enrolled from the intensive care units (ICUs) of 3 general hospitals. After being admitted to the ICU, the patients were continuously observed for 72 hours. Read More

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A case of sea anemone dermatitis associated with acute renal failure caused by Phyllodiscus semoni.

J Eur Acad Dermatol Venereol 2022 Jun 25. Epub 2022 Jun 25.

Department of Dermatology, Kawasaki municipal Ida hospital, Kanagawa, Japan.

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Neonates with acute liver failure have higher overall mortality but similar post-transplant outcomes as older infants.

Liver Transpl 2022 Jun 25. Epub 2022 Jun 25.

Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.

Background: Neonatal acute liver failure (ALF) carries a high mortality rate, however, little data exist on its peri-transplant hospital course. This project aimed to identify factors associated with outcomes in neonates with ALF using large multi-center databases.

Methods: Patients with ICD-9/10 codes for liver failure (2004-2018) from linked Pediatric Health Information System (PHIS) and Scientific Registry of Transplant Recipients (SRTR) databases were assigned to 2 groups: neonates < 30 days or older infants 31-120 days at admission. Read More

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Dedifferentiated liposarcoma (DDLPS) in the rectum: A case report.

J Int Med Res 2022 Jun;50(6):3000605221102081

Department of Colorectal and Anal Surgery, The Second Hospital of Jilin University, Changchun, Jilin Province, China.

Dedifferentiated liposarcoma (DDLPS) is a rare subtype of liposarcoma with a poor prognosis. This current case report describes a rectal DDLPS in a 68-year-old Chinese male that presented with lower abdominal pain and weight loss. Computed tomography and magnetic resonance imaging were undertaken to evaluate the tumour. Read More

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Prolonged jaundice in hepatitis-E patients: Going beyond the optics.

J Pak Med Assoc 2022 Jun;72(6):1229-1231

Department of Hematology, National Medical Centre, Karachi, Pakistan.

Hepatitis E virus (HEV) is an RNA virus that is transmitted faeco-orally. Due to unhygienic living conditions and unsatisfactory treatment of drinking water, it is a major cause of acute viral hepatitis in Pakistan. Hepatitis E infection in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency may cause prolonged jaundice resulting in serious complications like, severe haemolysis, acute renal failure, encephalopathy and even demise. Read More

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Community acquired versus hospital acquired acute kidney injury; causes and outcome.

J Pak Med Assoc 2022 Jun;72(6):1128-1132

Final Year MBBS Student, Aga Khan University Hospital, Karachi, Pakistan.

Objective: To evaluate causes of community-acquired and hospital-acquired acute kidney injury and the factors associated with increased inpatient mortality.

Methods: The observational prospective study was conducted at the Aga Khan University Hospital, Karachi, from September 2018 to March 2019, and comprised patients having acute kidney injury either at the time of admission in group A or developed it after 48 hours of hospital stay in group B. The patients were followed up for 12 weeks and outcomes were categorised as recovered, developed chronic kidney disease, died or remained dialysis-dependent. Read More

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Incidence of acute kidney injury and assessment of its associated risk factors in patients undergoing transarterial chemoembolisation for hepatocellular carcinoma.

J Pak Med Assoc 2022 Jun;72(6):1057-1060

Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.

Objective: To determine the incidence of acute kidney injury in intermediate stage hepatocellular carcinoma patients undergoing trans-arterial chemoembolisation, and to analyse various causative factors.

Methods: The retrospective study was conducted at the Shaukat Khanum Cancer Memorial Hospital, Lahore, Pakistan,, and comprised data from January 2012 to December 2015 of adult patients of either gender with intermediate stage hepatocellular carcinoma and undergoing trans-arterial chemoembolisation with Child-Pugh score A. Outcomes were measured in the form of development of acute kidney injury, and its causative factors. Read More

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Preoperative NT-proBNP and LVEF for the prediction of acute kidney injury after noncardiac surgery: a single-centre retrospective study.

BMC Anesthesiol 2022 Jun 24;22(1):196. Epub 2022 Jun 24.

Department of Anaesthesiology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, China.

Background: Acute kidney injury (AKI) is one of the most common postoperative complications in noncardiac surgical patients, has an important impact on prognosis and is difficult to predict. Whether preoperative N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations and left ventricular ejection fraction (LVEF) levels can predict postoperative AKI in noncardiac surgical patients is unclear.

Methods: We included 3,314 patients who underwent noncardiac surgery and had measurements of preoperative NT-proBNP concentrations and LVEF levels at a tertiary academic hospital in China between 2008 and 2018. Read More

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COVID-19 outcomes in patients with Dermatomyositis: A registry-based cohort analysis.

Semin Arthritis Rheum 2022 May 28:152034. Epub 2022 May 28.

Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI), Lucknow, Uttar Pradesh, India; Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK; Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, The University of Manchester, Manchester, UK.; City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK. Electronic address:

Background: Patients with rheumatic diseases (RDs) like DM are known to be vulnerable towards various types of infections due to aggressive disease activity mandating high dose immunosuppressive therapy. The severity of COVID-19 in RDs is limited in literature due to the heterogeneous nature of the condition. Therefore, specific details on mortality is essential to navigate any precautions required in the treatment. Read More

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Rare cause of diffuse alveolar haemorrhage and subconjunctival haemorrhage rescued by extracorporeal membrane oxygenation and rituximab.

BMJ Case Rep 2022 Jun 24;15(6). Epub 2022 Jun 24.

Department of Rheumatology, Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

A previously healthy man in his 20s presented with acute respiratory distress syndrome and subconjunctival haemorrhage. Imaging was indicative of pervasive pulmonary haemorrhage. There was no evidence of renal involvement. Read More

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Biochemical interaction of pyrvinium in gentamicin-induced acute kidney injury by modulating calcium dyshomeostasis and mitochondrial dysfunction.

Chem Biol Interact 2022 Jun 21:110020. Epub 2022 Jun 21.

School of Pharmacy, Suresh Gyan Vihar University, Jagatpura 302017, Mahal Road, Jaipur, India; Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India. Electronic address:

Acute kidney injury (AKI) has a poor clinical prognosis and increases the risk of chronic kidney failure (CKD). It is a common complication of organ failure in hospitalised patients (10-15% of all hospitalizations) and in intensive care unit (ICU) patients, with an incidence of up to 50%. Concerning ICU, AKI has a mortality rate ranging from 27% to 35%, rising to 60%-65% when dialysis is needed, with roughly 5%-20% of survivors requiring dialysis on discharge. Read More

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Trajectory of kidney recovery in pediatric patients requiring continuous kidney replacement therapy for acute kidney injury.

Clin Exp Nephrol 2022 Jun 24. Epub 2022 Jun 24.

Department of Critical Care and Anesthesia, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.

Background: Acute kidney injury (AKI) is commonly seen in the PICU and is associated with poor short-term and long-term outcomes, especially in patients who required continuous kidney replacement therapy (CKRT). However, as the trajectory of kidney recovery in these patients remain uncertain, determination of the timing to convert to permanent kidney replacement therapy (KRT) remains a major challenge. We aimed to examine the frequency and timing of kidney recovery in pediatric AKI survivors that required CKRT. Read More

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Urine bacterial culture growth and association with urine sedimentation and clinical findings in cats with acute kidney injury.

J Feline Med Surg 2022 Jun 24:1098612X221105309. Epub 2022 Jun 24.

Clinical Sciences, Oregon State University, Corvallis, OR, USA.

Objectives: A urine culture is often pursued in cats with acute kidney injury (AKI) to screen for bacterial growth in the urine, but it can be cost prohibitive. The aim of the study was to determine the ability of a urinalysis and lower urinary tract signs (LUTS) to predict urine culture results in cats with AKI.

Methods: Ninety-seven cats with AKI were included in this study. Read More

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Short-term control of diet affects cisplatin-induced acute kidney injury through modulation of mitochondrial dynamics and mitochondrial GSH.

Physiol Rep 2022 Jun;10(12):e15348

Department of Anatomy and BK21 Plus, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

Obesity affects acute kidney injury (AKI) induced by various clinical settings, including transplantation and cisplatin-cancer therapy. However, the effect of short-term food intake change remains to be defined. Here, we investigated the effects of short-term high-fat diet intake and food restriction on cisplatin-induced AKI. Read More

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1 black soybean against cisplatin-induced acute ren failure on rat model via antioxidant, antiinflammatory and antiapoptosis potential.

J Tradit Complement Med 2022 Jul 13;12(4):426-435. Epub 2022 Jan 13.

Aretha Medika Utama, Biomolecular and Biomedical Research Center, Jl. Babakan Jeruk II No. 9, Bandung, 40163, West Java, Indonesia.

Background And Aim: Cis-Diamminedichloroplatinum (II) (Cisplatin) is one of the most synthetic anticancer drug but have several adverse effects and one of them is acute ren failure. Cisplatin can induce nephrotoxicity occur via the toxic generation of reactive oxygen species (ROS). Black soybean ( max L. Read More

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Clinical presentation and short-term outcomes of multisystemic inflammatory syndrome in children in Lagos, Nigeria during the COVID-19 pandemic: A case series.

EClinicalMedicine 2022 Jul 27;49:101475. Epub 2022 May 27.

Department of Paediatrics, College of Medicine, University of Lagos, Lagos, Nigeria.

Background: Multisystemic inflammatory syndrome in children (MIS-C) has increasingly been documented globally with the progression of the COVID-19 pandemic and a significant proportion of cases have been noted in children of Black descent. There has been a noticeable discrepancy in the presentation and outcomes of COVID-19 infection in sub-Saharan Africa compared to the rest of the world. We documented the demography, clinical features, laboratory and imaging findings, therapeutic management, and short-term outcomes of paediatric patients with MIS-C diagnosed during the COVID-19 pandemic in Lagos, Nigeria. Read More

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Systemic injury caused by taurocholate-induced severe acute pancreatitis in rats.

Exp Ther Med 2022 Jul 26;24(1):468. Epub 2022 May 26.

Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.

Systemic injury plays a central role in severe acute pancreatitis (SAP). Retrograde biliopancreatic duct infusion of sodium taurocholate (NaT) is commonly used to establish SAP animal models. To better characterize the systemic injury in this model, SAP was induced in Sprague-Dawley rats by NaT administration (3. Read More

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Oliguria on the Day of Intubation Is Associated With Mortality in Patients With Acute Respiratory Distress Syndrome.

Crit Care Explor 2022 Jun 17;4(6):e0717. Epub 2022 Jun 17.

Department of Pulmonary and Critical Care Medicine, Henry Ford Hospital, Detroit, MI.

To investigate the relationship between oliguric acute kidney injury (AKI) and mortality in patients with acute respiratory distress syndrome (ARDS).

Design: Retrospective cohort study.

Setting: This investigation took place at a single-center, tertiary referral multidisciplinary comprehensive healthcare hospital in metropolitan Detroit, Michigan. Read More

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Extraordinary Creatine Phosphokinase Levels in Coxsackie B Necrotizing Myopathy Complicated by Rhabdomyolysis.

Cureus 2022 May 22;14(5):e25201. Epub 2022 May 22.

Internal Medicine, Ascension Providence Hospital, Southfield, USA.

Coxsackie B infections can have varying clinical presentations. Necrotizing myopathy and rhabdomyolysis with remarkably high creatine phosphokinase levels is a rare complication associated with high morbidity and mortality. A 28-year-old male presented with complaints of weakness, body aches, and decreased urine output. Read More

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Severe Rhabdomyolysis Complicated With Acute Kidney Injury Required Renal Replacement Therapy After Pfizer COVID-19 Vaccine  .

Cureus 2022 May 22;14(5):e25199. Epub 2022 May 22.

Internal Medicine, King Abdullaziz Medical City Jeddah, Jeddah, SAU.

The adverse effects of coronavirus disease 2019 (COVID-19) vaccines are somewhat common but rarely life-threatening. Diagnosing life-threatening vaccine-related adverse effects is heavily dependent on history taking and ruling out the other possible causes. Vaccine-related complications vary, so awareness of possible complications can lead to efficient management. Read More

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Suspected Levetiracetam-Induced Acute Rhabdomyolysis in a Patient With Retinoblastoma: A Case Report and Literature Review.

Cureus 2022 May 21;14(5):e25183. Epub 2022 May 21.

Internal Medicine, King Fahad Specialist Hospital, Eastern Health Cluster, Dammam, SAU.

Rhabdomyolysis is a condition characterized by the destruction of the skeletal muscle and the release of its content into the circulation, and it can cause acute kidney injury (AKI). There are numerous causes for the development of this condition, and some of them are rare. Levetiracetam, an antiepileptic agent, has been speculated as a rare possibility for the development of rhabdomyolysis. Read More

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A Case Report of Severe Dehydration Associated With Acute Kidney Injury Causing Acute ST-Segment Elevation Myocardial Infarction.

Cureus 2022 May 22;14(5):e25226. Epub 2022 May 22.

Cardiology Department, Dubai Hospital, Dubai Health Authority, Dubai, ARE.

The initial electrocardiogram finding in the setting of acute myocardial infarction typically shows either persistent ST-segment elevation or non-ST-segment elevation. In young adults, when coronary angiography is performed, can further classify the patient with an occluded vessel and those with non-occluded coronary arteries. In these subgroups, myocardial infarction can be explained on the basis of coronary artery thrombosis, embolization, spontaneous coronary artery dissection, myocardial bridging, coronary aneurysms, ectasia, anomalous origin of coronary arteries coronary microvascular dysfunction, and vasospasm, or a combination of these factors. Read More

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Mitochondrial targeted ROS Scavenger based on nitroxide for Treatment and MRI imaging of Acute Kidney Injury.

Free Radic Res 2022 Jun 23:1-32. Epub 2022 Jun 23.

School of Biomedical Engineering, Southern Medical University, Guangzhou, China.

Introduction: Overproduction of reactive oxygen species (ROS) during oxidative stress is a hallmark of acute kidney injure (AKI), which induced the damage to the renal cells and mitochondrial injury.

Purpose: In this contribution, we prepared mitochondrial targeted nitroxide, which linked 3-carboxy-2,2,5,5-tetramethylpyrrolidine 1-oxyl (carboxy-PROXYL) with (2-aminoethyl)triphenylphosphonium bromide (TPP), named TPP-PROXYL to eliminate the ROS and image the oxidative stress reaction by MRI.

Methods: 2,7-Dichlorodihydrofluorescein diacetate DCFH-DA) staining, mitochondrial membrane potential assay (JC-1) staining and transmission electron microscope (TEM) experiments were processed to verify that TPP-PROXYL could target mitochondria, scavenge the ROS, and prevent damage to mitochondria in live cells. Read More

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Protective Effects of Liquiritigenin against Cisplatin-Induced Nephrotoxicity via NRF2/SIRT3-Mediated Improvement of Mitochondrial Function.

Molecules 2022 Jun 14;27(12). Epub 2022 Jun 14.

Shandong Academy of Chinese Medicine, Jinan 250014, China.

Acute kidney injury (AKI) induced by cisplatin (CP), a first-line anticancer drug for chemotherapy, is common. To date, there is an urgent need to find effective treatments to reduce the nephrotoxicity caused by CP. Meanwhile, the restoration of mitochondrial dysfunction shows potential to be used as an adjunct to conventional therapeutic strategies. Read More

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Decreasing Significance of Early Allograft Dysfunction with Rising Use of Nonconventional Donors.

Medicina (Kaunas) 2022 Jun 17;58(6). Epub 2022 Jun 17.

Division of Transplant Surgery, Department of Surgery, Mayo Clinic, Phoenix, AZ 85054, USA.

Early allograft dysfunction (EAD) is considered a surrogate marker for adverse post-liver transplant (LT) outcomes. With the increasing use of nonconventional donors, EAD has become a more frequent occurrence. Given this background, we aimed to assess the prevalence and impact of EAD in an updated cohort inclusive of both conventional and nonconventional liver allografts. Read More

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Predictive Values of Procalcitonin and Presepsin for Acute Kidney Injury and 30-Day Hospital Mortality in Patients with COVID-19.

Medicina (Kaunas) 2022 May 28;58(6). Epub 2022 May 28.

Department of Emergency Medicine, Konkuk University School of Medicine, Seoul 05030, Korea.

: Acute kidney injury (AKI) is a common complication in patients with coronavirus disease 2019 (COVID-19). We investigated the values of procalcitonin (PCT) and presepsin (PSS) for predicting AKI and 30-day hospital mortality in patients with COVID-19. : We retrospectively evaluated 151 patients with COVID-19 who were admitted to the hospital via the emergency department. Read More

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Recovery of Renal Function in Clinical Patients with Acute Kidney Injury: Impact on Mortality.

Life (Basel) 2022 Jun 8;12(6). Epub 2022 Jun 8.

Nursing Department, College of Ceilândia, University of Brasília, Brasília 70910-900, Brazil.

Objective: To assess the different renal function recovery patterns and their impact on the mortality of non-critical patients with hospital-acquired Acute Kidney Injury.

Design: A prospective cohort study was conducted from January 2017 to December 2019.

Methods: The patients included were those with Acute Kidney Injury acquired during their hospitalization, identified from Kidney Disease: Improving Global Outcomes (KDIGO). Read More

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Genome-Wide Analyses of Nephrotoxicity in Platinum-Treated Cancer Patients Identify Association with Genetic Variant in and Acute Kidney Injury.

J Pers Med 2022 May 28;12(6). Epub 2022 May 28.

Department of Pediatrics, Radboud University Medical Center, Postbox 9101, 6500 HB Nijmegen, The Netherlands.

Nephrotoxicity is a common and dose-limiting side effect of platinum compounds, which often manifests as acute kidney injury or hypomagnesemia. This study aimed to investigate the genetic risk loci for platinum-induced nephrotoxicity. Platinum-treated brain tumor and head-neck tumor patients were genotyped with genome-wide coverage. Read More

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Distinct Phenotypes of Kidney Transplant Recipients in the United States with Limited Functional Status as Identified through Machine Learning Consensus Clustering.

J Pers Med 2022 May 25;12(6). Epub 2022 May 25.

Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Background: There have been concerns regarding increased perioperative mortality, length of hospital stay, and rates of graft loss in kidney transplant recipients with functional limitations. The application of machine learning consensus clustering approach may provide a novel understanding of unique phenotypes of functionally limited kidney transplant recipients with distinct outcomes in order to identify strategies to improve outcomes.

Methods: Consensus cluster analysis was performed based on recipient-, donor-, and transplant-related characteristics in 3205 functionally limited kidney transplant recipients (Karnofsky Performance Scale (KPS) < 40% at transplant) in the OPTN/UNOS database from 2010 to 2019. Read More

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