85,713 results match your criteria Acute Renal Failure


Regional Oxygen Saturation and Acute Kidney Injury in Premature Infants.

Pediatr Int 2020 Jul 7. Epub 2020 Jul 7.

Uludag University, Faculty of Medicine, Department of Neonatology, Bursa, Turkey.

Background: Decreased renal blood flow plays a vital role in the etiology of acute kidney injury (AKI). In this study, we aim to investigate the role of renal regional oxygen saturation (rSO ) reductions in predicting AKI in the first 24 hours of life.

Methods: One-hundred premature babies with a gestational age of ≤32 weeks were included. Read More

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http://dx.doi.org/10.1111/ped.14377DOI Listing

Distinct clinical characteristics and risk factors for mortality in female COVID-19 inpatients: a sex-stratified large-scale cohort study in Wuhan, China.

Clin Infect Dis 2020 Jul 8. Epub 2020 Jul 8.

Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology.

Background: As the coronavirus disease 2019 (COVID-19) outbreak accelerates worldwide, it is highly significant to evaluate sex-specific clinical characteristics and outcomes, that may affect public health policies.

Methods: COVID-19 patients admitted to Tongji Hospital between January 18and March 27, 2020 were evaluated. Clinical features, laboratory data, complications and outcomes were compared between females and males. Read More

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http://dx.doi.org/10.1093/cid/ciaa920DOI Listing

Outcome of Selective Renal Artery Embolization in Managing Severe Bleeding after Percutaneous Nephrolithotomy.

Urol Int 2020 Jul 7:1-6. Epub 2020 Jul 7.

Urology and Lithotripsy Center, Peking University People's Hospital, Peking, China.

Objectives: The aim of this study was to evaluate the characteristics of the renal arterial segment bleeding and assess the outcome of selective renal artery embolization (SRAE).

Methods: Data on 35 patients in whom SRAE was performed after percutaneous nephrolithotomy (PCNL) from January 2005 to December 2015 in our institute were retrospectively analyzed. All patients had severe bleeding but failed to respond to conservative therapy. Read More

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http://dx.doi.org/10.1159/000508797DOI Listing

Upregulated miR-101 inhibits acute kidney injury-chronic kidney disease transition by regulating epithelial-mesenchymal transition.

Hum Exp Toxicol 2020 Jul 7:960327120937334. Epub 2020 Jul 7.

Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.

Acute kidney injury (AKI) is an independent risk factor for chronic kidney disease (CKD). However, the role and mechanism of microRNA (miRNA, miR) in AKI-CKD transition are elusive. In this study, a murine model of renal ischemia/reperfusion was established to investigate the repairing effect and mechanism of miR-101a-3p on renal injury. Read More

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http://dx.doi.org/10.1177/0960327120937334DOI Listing

Prevalence and prognostic impact of subclinical pulmonary congestion at discharge in patients with acute heart failure.

ESC Heart Fail 2020 Jul 7. Epub 2020 Jul 7.

Cardiology Department, Hospital de la Santa Creu i Sant Pau, IIb-SantPau, CIBERCV, Universitat Autónoma de Barcelona, Barcelona, Spain.

Aims: Residual pulmonary congestion at hospital discharge can worsen the outcomes in patients with heart failure (HF) and can be detected by lung ultrasound (LUS). The aim of this study was to analyse the prevalence of subclinical pulmonary congestion at discharge and its impact on prognosis in patients admitted for acute HF.

Methods And Results: This is a post-hoc analysis of the LUS-HF trial. Read More

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http://dx.doi.org/10.1002/ehf2.12842DOI Listing

Reduced genioglossus muscle activity caused by fluid overload in anesthetized rats.

Physiol Rep 2020 Jul;8(13):e14445

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.

Introduction: Although the precise cause of obstructive sleep apnea (OSA) remains unknown, various anatomical or structural factors are thought to influence upper airway patency. Recent clinical studies show that OSA is frequently observed among patients with fluid-retaining states, such as heart/renal failure and postsurgery. It is important to note that a cause-effect relationship is not yet established, and our understanding of the effects of fluid overload is limited. Read More

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http://dx.doi.org/10.14814/phy2.14445DOI Listing

SARS, MERS, COVID-19: Clinical Manifestations and Organ-System Complications: A Mini Review.

Pathog Dis 2020 Jul 7. Epub 2020 Jul 7.

Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon.

Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS) and Coronavirus Disease 2019 (COVID-19) are caused by three distinct coronaviruses belonging to the same genus. COVID-19 and its two predecessors share many important features in their clinical presentations, and in their propensity for progression to severe disease which is marked by high rates of morbidity and mortality. However, comparison of the three viral illnesses also reveals a number of specific differences in clinical manifestations and complications, which suggest variability in the disease process. Read More

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http://dx.doi.org/10.1093/femspd/ftaa033DOI Listing

Renal sympathetic denervation lowers systemic vascular resistance in true treatment-resistant hypertension.

Blood Press 2020 Jul 7:1-10. Epub 2020 Jul 7.

Section of Cardiovascular and Renal Research, Oslo University Hospital, Oslo, Norway.

Purpose: Renal sympathetic denervation (RDN) is again gaining interest as recent well-designed trials have demonstrated reduced ambulatory blood pressure (BP) after RDN. However, the hemodynamic mechanisms have not been elucidated. We aimed for the first time to investigate the effect of RDN on the "Hallmark of Hypertension" namely increased systemic vascular resistance index (SVRI). Read More

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http://dx.doi.org/10.1080/08037051.2020.1789446DOI Listing

An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure.

Nat Biomed Eng 2020 Jul 6. Epub 2020 Jul 6.

Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, People's Republic of China.

Patients with kidney failure commonly require dialysis to remove nitrogenous wastes and to reduce burden to the kidney. Here, we show that a bacterial cocktail orally delivered in animals with kidney injury can metabolize blood nitrogenous waste products before they diffuse through the intestinal mucosal barrier. The microbial cocktail consists of three strains of bacteria isolated from faecal microbiota that metabolize urea and creatinine into amino acids, and is encapsulated in calcium alginate microspheres coated with a polydopamine layer that is selectively permeable to small-molecule nitrogenous wastes. Read More

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http://dx.doi.org/10.1038/s41551-020-0582-1DOI Listing

Public health benefits of water purification using recycled hemodialyzers in developing countries.

Sci Rep 2020 Jul 6;10(1):11101. Epub 2020 Jul 6.

Easy Water for Everyone, 10 Bank Street, Suite 560, White Plains, NY, 10606, USA.

In rural regions with limited resources, the provision of clean water remains challenging. The resulting high incidence of diarrhea can lead to acute kidney injury and death, particularly in the young and the old. Membrane filtration using recycled hemodialyzers allows water purification. Read More

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http://dx.doi.org/10.1038/s41598-020-68408-1DOI Listing

Acute kidney injury after cytoreductive surgery and hyperthermic intraoperative cisplatin chemotherapy for malignant pleural mesothelioma.

J Thorac Cardiovasc Surg 2020 May 29. Epub 2020 May 29.

Division of Renal Medicine, Brigham and Women's Hospital, Boston, Mass; Section of Nephrology, Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, Mass. Electronic address:

Objectives: Cytoreductive surgery with hyperthermic intraoperative chemotherapy with cisplatin has been used successfully to treat malignant pleural mesothelioma, a highly aggressive malignancy that is rapidly fatal in most cases. We hypothesized that the combination of ischemic injury with nephrotoxic injury from cisplatin would result in high rates of acute kidney injury.

Methods: We conducted an observational study in 503 patients to study the risks and outcomes of acute kidney injury after surgical resection of malignant pleural mesothelioma. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2020.05.033DOI Listing

Monitoring renal damage in acute heart failure. Do we need a more global and comprehensive approach?

Rev Clin Esp 2020 Jul 3. Epub 2020 Jul 3.

Hospital Clinic Barcelona. Universidad de Barcelona, Barcelona, España.

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http://dx.doi.org/10.1016/j.rce.2020.02.005DOI Listing

Sex Differences in Clinical Characteristics and 1- and 10-Year Mortality Among Patients Hospitalized With Acute Heart Failure.

Am J Med Sci 2020 May 27. Epub 2020 May 27.

The Leviev Heart Center, Sheba Medical Center, Tel Hashomer and Sakler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Background: The impact of sex on mortality in patients with acute heart failure (AHF) is unresolved. We aimed to investigate the impact of sex on both short- and long-term mortality outcomes after hospitalization for AHF.

Methods: We analyzed data of 2,328 patients with AHF who were enrolled in the multicenter national survey in Israel between March and April 2003 and followed up until December 2014. Read More

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http://dx.doi.org/10.1016/j.amjms.2020.05.028DOI Listing

Clinical course and predictors of 60-day mortality in 239 critically ill patients with COVID-19: a multicenter retrospective study from Wuhan, China.

Crit Care 2020 07 6;24(1):394. Epub 2020 Jul 6.

Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: The global numbers of confirmed cases and deceased critically ill patients with COVID-19 are increasing. However, the clinical course, and the 60-day mortality and its predictors in critically ill patients have not been fully elucidated. The aim of this study is to identify the clinical course, and 60-day mortality and its predictors in critically ill patients with COVID-19. Read More

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http://dx.doi.org/10.1186/s13054-020-03098-9DOI Listing

Rapid exacerbation featuring acute leukemoid reaction after retrolaparoscopic nephrectomy: a rare case report of renal cell carcinoma with postoperative comprehensive genomic profiling.

World J Surg Oncol 2020 Jul 6;18(1):155. Epub 2020 Jul 6.

Department of Urology, First Hospital of Shanxi Medical University, No. 85, Jiefangnan Road, Taiyuan, 030001, Shanxi, China.

Background: Rapid lethal exacerbation and recurrence featuring acute leukemoid reaction (ALR) after retrolaparoscopic radical nephrectomy (RN) is a relatively rare clinical incident. Performing the reoperation for the patient and analyzing the tissue-based genetic mutation information postoperatively are a skill-demanding and meaningful task, which have been even more rarely reported.

Case Presentation: We present a case with a large right renal mass (13. Read More

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http://dx.doi.org/10.1186/s12957-020-01926-4DOI Listing

Prior bariatric surgery and perioperative cardiovascular outcomes following noncardiac surgery in patients with type 2 diabetes mellitus: hint from National Inpatient Sample Database.

Cardiovasc Diabetol 2020 Jul 6;19(1):103. Epub 2020 Jul 6.

Department of Endocrinology, The First Affiliated Hospital, Sun Yat-Sen University, No. 58, Zhong Shan Er Lu, Guangzhou, 510080, China.

Background: Both diabetes and obesity are risk factors for perioperative major adverse events. This study aims to evaluate the association between prior bariatric surgery (prior-BS) and perioperative cardiovascular outcomes following noncardiac surgery in patients with type 2 diabetes mellitus (T2DM).

Methods: We used the National Inpatient Sample Database to identify T2DM patients undergoing major noncardiac surgery from 2006 to 2014. Read More

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http://dx.doi.org/10.1186/s12933-020-01084-7DOI Listing

The Many Faces of Matrix Metalloproteinase-7 in Kidney Diseases.

Biomolecules 2020 Jun 25;10(6). Epub 2020 Jun 25.

State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Matrix metalloproteinase-7 (MMP-7) is a secreted zinc-dependent endopeptidase that is implicated in regulating kidney homeostasis and diseases. MMP-7 is produced as an inactive zymogen, and proteolytic cleavage is required for its activation. MMP-7 is barely expressed in normal adult kidney but upregulated in acute kidney injury (AKI) and chronic kidney disease (CKD). Read More

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http://dx.doi.org/10.3390/biom10060960DOI Listing

New Biomarkers in Acute Tubulointerstitial Nephritis: A Novel Approach to a Classic Condition.

Int J Mol Sci 2020 Jun 30;21(13). Epub 2020 Jun 30.

Bellvitge University Hospital, Nephrology Department, 08907 Hospitalet de Llobregat, Barcelona, Spain.

Acute tubulointerstitial nephritis (ATIN) is an immunomediated cause of acute kidney injury. The prevalence of ATIN among the causes of acute kidney injury (AKI) is not negligible, especially those cases related to certain drugs. To date, there is a lack of reliable non-invasive diagnostic and follow-up markers. Read More

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http://dx.doi.org/10.3390/ijms21134690DOI Listing

Prediction Value of Serum NGAL in the Diagnosis and Prognosis of Experimental Acute and Chronic Kidney Injuries.

Biomolecules 2020 Jun 30;10(7). Epub 2020 Jun 30.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Sensitive and accurate serum biomarkers for monitoring acute and chronic kidney disease progression are more convenient and can better evaluate drug efficiency in pharmacological research. Neutrophil Gelatinase-associated Lipocalin (NGAL) is considered a hopeful early biomarker of acute kidney injury (AKI), but its utility in early prediction and prognosis of diabetic nephropathy (DN) and immune-mediated glomerulonephritis is still not clear. Moreover, detailed prognosis studies of NGAL in AKI are lacking, and most studies use a urine source. Read More

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http://dx.doi.org/10.3390/biom10070981DOI Listing

Monoclonal Gammopathies of Renal Significance: Renal Biopsy and Beyond.

Cancers (Basel) 2020 Jun 30;12(7). Epub 2020 Jun 30.

Divisions of Nephrology, General Pathology, and Pathology, Department of Clinical and Molecular Medicine, "Sapienza" University of Rome, 00189 Rome, Italy.

Monoclonal Gammopathies of Renal Significance (MGRS) are a rather heterogeneous group of renal disorders caused by a circulating monoclonal (MC) immunoglobulin (Ig) component, often in the absence of multiple myeloma (MM) or another clinically relevant lymphoproliferative disorder. Nevertheless, substantial kidney damage could occur, despite the "benign" features of the bone-marrow biopsy. One example is renal amyloidosis, often linked to a small clone of plasma cells, without the invasive features of MM. Read More

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http://dx.doi.org/10.3390/cancers12071741DOI Listing

[Study on the protective effect and mechanism of somatostatin on renal injury in paraquat intoxicated mice].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020 Jun;38(6):410-415

Emergency Department of the First Affiliated Hospital of Wenzhou Medical University, Yiwu 325000, China.

To investigate the protective effect of somatostatin (SS) on acute kidney injury (AKI) of paraquat (PQ) poisoned mice and its mechanism. From December 2017 to April 2018, a total of 48 SPF male BALB/C mice were selected and randomly divided into 4 groups, with 12 mice in each group: Control group, SS group (20 mg/kg SS was injected 1 hour before and 3 hours after gavage with normal saline) , PQ group (2% PQ 60 mg/kg by gavage) and PQ+SS group (Intragastric administration was performed with 2% PQ solution of 60 mg/kg, and 20 mg/kg SS was administered 1 h before and 3 h after intragastric administration) , 12 mice in each group were observed for the general situation and behavioral effects. After 24 hours of modeling, mice were sacrificed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.cn121094-20190726-00295DOI Listing

SOCIETY FOR VASCULAR SURGERY CLINICAL PRACTICE GUIDELINES FOR THORACIC ENDOVASCULAR ANEURYSM REPAIR (TEVAR).

J Vasc Surg 2020 Jul 3. Epub 2020 Jul 3.

University of Pennsylvania, Philadelphia, PA.

Thoracic aortic diseases, including disease of the descending thoracic aorta (DTA), are significant causes of death in the United States. Open repair of DTA is a physiologically impactful operation with relatively high rates of mortality, paraplegia, and renal failure. Thoracic endovascular aneurysm repair (TEVAR) has revolutionized the treatment of DTA, and has largely supplanted open repair due to lower morbidity and mortality. Read More

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http://dx.doi.org/10.1016/j.jvs.2020.05.076DOI Listing

Twists and Turns: An Unusual Intra-Abdominal Cause of Heart Failure.

Am J Med 2020 Jul 3. Epub 2020 Jul 3.

Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2020.05.036DOI Listing

Persistent cardiac arrest caused by profound hypokalaemia after large-dose insulin injection in a young man with type 1 diabetes mellitus: successful rescue with extracorporeal membrane oxygenation and subsequent ventricular assist device.

Cardiovasc J Afr 2020 Jul 6;31:1-4. Epub 2020 Jul 6.

Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Email:

A 28-year-old man who had a history of type 1 diabetes mellitus with poor medication compliance was referred to the emergency department of our institute with suspected diabetic ketoacidosis. The patient developed sudden cardiac arrest following continuous insulin administration. Laboratory data revealed severe hypokalaemia. Read More

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http://dx.doi.org/10.5830/CVJA-2020-018DOI Listing

Trends of Clinical Outcomes and Health Care Resource Use in Heart Failure in the United States.

J Am Heart Assoc 2020 Jul 4:e016782. Epub 2020 Jul 4.

Department of Cardiovascular Medicine Mayo Clinic Rochester MN.

Background Heart failure (HF) imparts a significant clinical and economic burden on the health system in the United States. Methods and Results We used the National Inpatient Sample database between September 2002 and December 2016. We examined trends of comorbidities, inpatient mortality, and healthcare resource use in patients admitted with acute HF. Read More

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http://dx.doi.org/10.1161/JAHA.120.016782DOI Listing

An Ultrasmall RuO Nanozyme Exhibiting Multienzyme-like Activity for the Prevention of Acute Kidney Injury.

ACS Appl Mater Interfaces 2020 Jul 6. Epub 2020 Jul 6.

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China.

Oxidative stress induced by reactive oxygen species (ROS) is one of the major pathological mechanisms of acute kidney injury (AKI). Inorganic nanomaterial-mediated antioxidant therapy is considered a promising method for the prevention of AKI; however, currently available antioxidants for AKI exhibit limited clinical efficacy due to the glomerular filtration threshold (∼6 nm). To address this issue, we developed ultrasmall RuO nanoparticles (RuONPs) (average size ≈ 2 nm). Read More

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http://dx.doi.org/10.1021/acsami.0c07886DOI Listing

Transcatheter aortic valve implantation (TAVI) in cardiogenic shock: TAVI-shock registry results.

Catheter Cardiovasc Interv 2020 Jul 6. Epub 2020 Jul 6.

Interventional Cardiology Unit, Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Padua, Italy.

Objectives: Aim of this study is to evaluate safety, feasibility, and mid-term outcome of transcatheter aortic valve implantation (TAVI) in cardiogenic shock (CS).

Background: Balloon aortic valvuloplasty in patients with severe aortic valve stenosis (SAS) complicated by CS is indicated but associated with a grim prognosis. TAVI might be a more reasonable treatment option in this setting but data are scant. Read More

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http://dx.doi.org/10.1002/ccd.29112DOI Listing

Validation of a commercial magnetic bead-based multiplex assay for 5 novel biomarkers of acute kidney injury in canine serum.

J Vet Diagn Invest 2020 Jul 5:1040638720939520. Epub 2020 Jul 5.

College of Veterinary Medicine, School of Science, Health, Engineering, and Education, Murdoch University, Murdoch, Western Australia, Australia.

Interest is growing in measurement of novel biomarkers for the diagnosis of acute kidney injury. Multiplex assays may provide a rapid and cost-effective way of measurement; however, sparse information is published regarding their use in dogs. We aimed to validate a commercial magnetic bead-based assay for 5 biomarkers: clusterin (Clus), cystatin C (CysC), kidney injury molecule 1 (KIM-1), monocyte chemoattractant protein 1 (MCP-1), and neutrophil gelatinase-associated lipocalin (NGAL). Read More

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http://dx.doi.org/10.1177/1040638720939520DOI Listing

The Correlation of Comorbidities on the Mortality in Patients with COVID-19: an Observational Study Based on the Korean National Health Insurance Big Data.

J Korean Med Sci 2020 Jul 6;35(26):e243. Epub 2020 Jul 6.

Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea.

Background: Mortality of coronavirus disease 2019 (COVID-19) is a major concern for quarantine departments in all countries. This is because the mortality of infectious diseases determines the basic policy stance of measures to prevent infectious diseases. Early screening of high-risk groups and taking action are the basics of disease management. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e243DOI Listing

Long-term Renal Outcome of Biopsy-proven Acute Tubular Necrosis and Acute Interstitial Nephritis.

J Korean Med Sci 2020 Jul 6;35(26):e206. Epub 2020 Jul 6.

Division of Nephrology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.

Background: Although emerging evidence suggest acute kidney injury (AKI) progress to chronic kidney disease (CKD), long-term renal outcome of AKI still remains unclear. Acute tubular necrosis (ATN) is the most common cause of AKI due to ischemia, toxin or sepsis. Acute interstitial nephritis (AIN), caused by drugs or autoimmune diseases is also increasingly recognized as an important cause of AKI. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e206DOI Listing

Analysis of the association between kidney injury biomarkers concentration and nephritis in immunoglobulin A vasculitis: A pediatric cohort study.

Int J Rheum Dis 2020 Jul 5. Epub 2020 Jul 5.

Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland.

Objective: The aim of this study was to investigate the clinical course, selected biochemical parameters and concentrations of renal injury biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1) and liver-fatty acid binding protein (L-FABP) in patients with immunoglobulin A vasculitis (IgAV) to identify the markers associated with nephritis in the course of the disease (IgAVN).

Methods: The study involved 29 children with IgAV and 34 healthy controls. Eleven (38%) patients had renal involvement (IgAV-N) and 18 (62%) did not exhibit nephritis (IgAV-noN). Read More

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http://dx.doi.org/10.1111/1756-185X.13904DOI Listing

Autophagy regulation is an effective strategy to improve the prognosis of chemically induced acute liver injury based on experimental studies.

J Cell Mol Med 2020 Jul 6. Epub 2020 Jul 6.

Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China.

Acute liver injury (ALI) induced by chemicals in current experimental studies is characterized by inflammation, oxidative stress and necrosis, which can greatly influence the long-term outcome and lead to liver failure. In liver cells, different autophagy forms envelop cytoplasm components, including proteins, endoplasmic reticulum (ER), mitochondria and lipids, and they effectively participate in breaking down the cargo enclosed inside lysosomes to replenish cellular energy and contents. In general, autophagy serves as a cell survival mechanism in stressful microenvironments, but it also serves as a destructive mechanism that results in cell death in vitro and in vivo. Read More

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http://dx.doi.org/10.1111/jcmm.15565DOI Listing

Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage.

Mol Cell Biochem 2020 Jul 5. Epub 2020 Jul 5.

Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong, China.

P2X7 receptor (P2X7R) is an ATP-gated non-selective cation channel which mediates ATP-induced inflammation in macrophages. Transient receptor potential (TRP) receptors are nociceptors in cellular membrane which can perceive the stimuli of environmental irritant. The interaction between TRP channels and P2X7R has been found while the details about inflammation are still unclear. Read More

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http://dx.doi.org/10.1007/s11010-020-03818-3DOI Listing

Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALB/c Mice.

Biomed Res Int 2020 16;2020:1594726. Epub 2020 Jun 16.

Department of Infection, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Dalian, China.

Acute kidney injury (AKI) is a common complication of sepsis and has also been observed in some patients suffering from the new coronavirus pneumonia COVID-19, which is currently a major global concern. Thymoquinone (TQ) is one of the most active ingredients in seeds. It has a variety of beneficial properties including anti-inflammatory and antioxidative activities. Read More

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http://dx.doi.org/10.1155/2020/1594726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315249PMC

Acute Kidney Injury in Oncology Patients.

J Cancer 2020 22;11(16):4700-4708. Epub 2020 May 22.

Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

With rapid progress in cancer diagnosis and treatment in the last two decades, outcomes in oncological patients have improved significantly. However, the incidence of acute kidney injury (AKI) in this population has also increased significantly. AKI complicates many aspects of patients' care and adversely affects their prognoses; thus, accurately diagnosing the risk factors for AKI ensures appropriate management. Read More

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http://dx.doi.org/10.7150/jca.45382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330685PMC

Outcome in Patients Resuscitated following Myocardial Infarction with Acute Kidney Injury.

Int J Med Sci 2020 29;17(10):1333-1339. Epub 2020 May 29.

University Medical Center Maribor, Maribor, Slovenia.

Data on acute kidney injury (AKI) in patients with myocardial infarction (MI) who underwent percutaneous coronary intervention (PCI) after cardiac arrest are scarce. The prevalence of AKI, as classified by the Kidney Disease: Improving Global Outcomes (KDIGO) criteria; and its possible association with 30-day mortality were assessed. Data on 6387 patients with MI, 342 (5. Read More

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http://dx.doi.org/10.7150/ijms.45686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330674PMC

Early urinary sodium trajectory and risk of adverse outcomes in acute heart failure and renal dysfunction.

Rev Esp Cardiol (Engl Ed) 2020 Jul 2. Epub 2020 Jul 2.

Servicio de Cardiología, Hospital Clínico Universitario de Valencia, Universitat de Valencia, Fundación Investigación Clínico de Valencia - Instituto de Investigación Sanitaria (INCLIVA), Valencia, Spain; Centro de Investigación en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. Electronic address:

Introduction And Objectives: Urinary sodium (UNa) has emerged as a useful biomarker of poor clinical outcomes in acute heart failure (AHF). Here, we sought to evaluate: a) the usefulness of a single early determination of UNa for predicting adverse outcomes in patients with AHF and renal dysfunction, and b) whether the change in UNa at 24hours (ΔUNa24h) adds any additional prognostic information over baseline values.

Methods: This is a post-hoc analysis of a multicenter, open-label, randomized clinical trial (IMPROVE-HF) (ClinicalTrials. Read More

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http://dx.doi.org/10.1016/j.rec.2020.06.004DOI Listing

Risk factor for acute kidney injury in patients with chronic kidney disease receiving valve surgery with cardiopulmonary bypass.

Asian J Surg 2020 Jul 2. Epub 2020 Jul 2.

Department of Cardiac Surgery, National Taiwan University Hospital, And School of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Introduction: Acute kidney injury (AKI) after cardiopulmonary bypass (CPB) in patients with pre-existing impaired renal function carries deleterious outcomes but is not frequently evaluated. The optimal CPB strategy for preventing AKI in this vulnerable patient group is still controversial.

Methods: A total of 156 patients with preoperative estimated glomerular filtration rate (e-GFR) <30 ml/min but not on chronic dialysis receiving valve operation under CPB were included in the present study. Read More

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http://dx.doi.org/10.1016/j.asjsur.2020.05.024DOI Listing

Ferroptosis and kidney disease.

Nefrologia 2020 Jul 2. Epub 2020 Jul 2.

Research Institute-Fundacion Jimenez Diaz, Autonoma University, Madrid, Spain; REDINREN, Madrid, Spain. Electronic address:

Cell death is a finely regulated process occurring through different pathways. Regulated cell death, either through apoptosis or regulated necrosis offers the possibility of therapeutic intervention. Necroptosis and ferroptosis are among the best studied forms of regulated necrosis in the context of kidney disease. Read More

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http://dx.doi.org/10.1016/j.nefro.2020.03.005DOI Listing

Mortality prediction of serum neutrophil gelatinase-associated lipocalin in patients requiring continuous renal replacement therapy.

Korean J Intern Med 2020 07 7. Epub 2020 Jul 7.

Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background/aims: We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) can predict mortality in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT).

Methods: This study enrolled 169 patients who underwent serum NGAL testing at CRRT initiation from June 2017 to January 2019. The predictive power of serum NGAL level for 28-day mortality was compared to the Acute Physiology and Chronic Health Evaluation-II (APACHE-II) score and Sequential Organ Failure Assessment (SOFA) score via area under the receiver operating characteristic curve (AuROC) value. Read More

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http://dx.doi.org/10.3904/kjim.2019.446DOI Listing

Hemostatic Changes of Acute Kidney Injury in Patients With Cirrhosis: What Do They Mean?

Authors:
Ton Lisman

Hepatology 2020 Jul 4. Epub 2020 Jul 4.

Surgical Research Laboratory and Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Historically, patients with liver disease were considered to have a bleeding tendency that was a consequence of changes in their hemostatic system. An important consequence of this concept is the ever-ongoing policy of prophylactic blood product transfusion prior to invasive procedures aimed to reduce bleeding risk. However, it is increasingly acknowledged that although bleeding in patients with liver diseases can be the consequence of a (temporal) hypocoagulable state, it is frequently unrelated to hemostatic failure and rather caused by portal hypertension (e. Read More

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http://dx.doi.org/10.1002/hep.31451DOI Listing

A case of acute renal failure with multiple origins of the renal injury.

CEN Case Rep 2020 Jul 4. Epub 2020 Jul 4.

Nephrology and Dialysis Unit, Belcolle Hospital, Via Sammartinese, Snc, 01100, Viterbo, Italy.

Acute kidney injury (AKI) is an abrupt and usually reversible decline in the glomerular filtration rate (GFR). Patients with AKI must be evaluated promptly to determine cause. Different disorders can BE associated with AKI, and biopsy is the most accurate instrument for diagnosis of different types of diseases. Read More

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http://dx.doi.org/10.1007/s13730-020-00505-6DOI Listing

Long-Term ACE Inhibitor/ARB Use Is Associated with Severe Renal Dysfunction and Acute Kidney Injury in Patients with severe COVID-19: Results from a Referral Center Cohort in the North East of France.

Clin Infect Dis 2020 Jul 5. Epub 2020 Jul 5.

Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, Nancy, France.

Background: In patients with severe COVID-19, data are scarce and conflicting regarding whether chronic use of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) influences disease outcomes. In patients with severe COVID-19, we assessed the association between chronic ACEI/ARB use and the occurrence of kidney, lung, heart, and liver dysfunctions and the severity of the inflammatory reaction as evaluated by biomarkers kinetics, and their association with disease outcomes.

Methods: We performed a retrospective longitudinal cohort study on consecutive patients with newly diagnosed severe COVID-19. Read More

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http://dx.doi.org/10.1093/cid/ciaa677DOI Listing

Phosphodiesterase-5 inhibitors ameliorate structural kidney damage in a rat model of contrast-induced nephropathy.

Food Chem Toxicol 2020 Jul 2:111535. Epub 2020 Jul 2.

Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania. Electronic address:

The aim of the study was to investigate the potential of sildenafil and tadalafil to ameliorate structural kidney damage in contrast-induced nephropathy (CIN). A rat model of CIN was developed by dehydration, administration of a nitric oxide inhibitor and a prostaglandin synthesis inhibitor (L-NAME/indomethacin) and contrast media exposure to iopromide. The effect of pre-treatment with sildenafil, tadalafil or N-acetyl cysteine (NAC) for 7 days prior to CIN induction was investigated. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111535DOI Listing

Rutaecarpine Derivative Cpd-6c Alleviates Acute Kidney Injury by Targeting PDE4B, a Key Enzyme Mediating inflammation in Cisplatin Nephropathy.

Biochem Pharmacol 2020 Jul 2:114132. Epub 2020 Jul 2.

The Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, The key laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei 230032, China. Electronic address:

Acute kidney injury (AKI), characterized by a rapid decline in renal function, is triggered by an acute inflammatory response that leads to kidney damage. An effective treatment for AKI is lacking. Using in vitro and in vivo AKI models, our laboratory has identified a series of anti-inflammatory molecules and their derivatives. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114132DOI Listing

Clinical Application of Kidney Biomarkers in Cirrhosis.

Am J Kidney Dis 2020 Jul 1. Epub 2020 Jul 1.

Liver Unit, Hospital Clínic, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Catalonia, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Catalonia, Spain; Centro de Investigación Biomédicaen Red de Enfermedades Hepáticas y Digestivas, Barcelona, Catalonia, Spain; Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Catalonia, Spain.

Acute kidney injury (AKI) is one of the most common and morbid complications of decompensated cirrhosis. Management of AKI is dictated by cause: prerenal AKI is treated with volume resuscitation; hepatorenal syndrome (HRS), with intravenous albumin and vasoconstrictors; and acute tubular necrosis, with supportive care. However, differentiating between causes is difficult using creatinine-based definitions of AKI alone. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.03.016DOI Listing

A Collaborative Multidisciplinary Approach to the Management of Coronavirus Disease 2019 in the Hospital Setting.

Mayo Clin Proc 2020 07 30;95(7):1467-1481. Epub 2020 May 30.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which presents an unprecedented challenge to medical providers worldwide. Although most SARS-CoV-2-infected individuals manifest with a self-limited mild disease that resolves with supportive care in the outpatient setting, patients with moderate to severe COVID-19 will require a multidisciplinary collaborative management approach for optimal care in the hospital setting. Laboratory and radiologic studies provide critical information on disease severity, management options, and overall prognosis. Read More

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http://dx.doi.org/10.1016/j.mayocp.2020.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260518PMC

Neurobiology of coronaviruses: Potential relevance for COVID-19.

Neurobiol Dis 2020 Jul 1:105007. Epub 2020 Jul 1.

Division of Pharmacology, Department of Neuroscience, University of Naples "Federico II", 80131 Naples, Italy. Electronic address:

In the first two decades of the 21st century, there have been three outbreaks of severe respiratory infections caused by highly pathogenic coronaviruses (CoVs) around the world: the severe acute respiratory syndrome (SARS) by the SARS-CoV in 2002-2003, the Middle East respiratory syndrome (MERS) by the MERS-CoV in June 2012, and Coronavirus Disease 2019 (COVID-19) by the SARS-CoV-2 presently affecting most countries In all of these, fatalities are a consequence of a multiorgan dysregulation caused by pulmonary, renal, cardiac, and circulatory damage; however, COVID patients may show significant neurological signs and symptoms such as headache, nausea, vomiting, and sensory disturbances, the most prominent being anosmia and ageusia. The neuroinvasive potential of CoVs might be responsible for at least part of these symptoms and may contribute to the respiratory failure observed in affected patients. Therefore, in the present manuscript, we have reviewed the available preclinical evidence on the mechanisms and consequences of CoVs-induced CNS damage, and highlighted the potential role of CoVs in determining or aggravating acute and long-term neurological diseases in infected individuals. Read More

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http://dx.doi.org/10.1016/j.nbd.2020.105007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329662PMC

The renal safety of a single dose of gentamicin in patients with sepsis in the emergency department.

Clin Microbiol Infect 2020 Jul 1. Epub 2020 Jul 1.

CAPHRI School for Public Health and Primary Care, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands; Department of Internal Medicine, Division of General Medicine, Section Acute Medicine, Maastricht University Medical Center, Maastricht, the Netherlands.

Objectives: To determine the effect of a single-dose of gentamicin on the incidence and persistence of acute kidney injury (AKI) in patients with sepsis in the emergency department (ED).

Methods: We retrospectively enrolled patients with sepsis in the ED in three hospitals. Local antibiotic guidelines recommended a single-dose of gentamicin as part of empirical therapy in selected patients in one hospital, whereas the other two hospitals did not. Read More

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http://dx.doi.org/10.1016/j.cmi.2020.06.030DOI Listing

Dexmedetomidine pretreatment attenuates myocardial ischemia reperfusion induced acute kidney injury and endoplasmic reticulum stress in human and rat.

Life Sci 2020 Jul 1:118004. Epub 2020 Jul 1.

Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui, China. Electronic address:

Background: Patients undergoing cardiopulmonary bypass (CPB) often develop acute kidney injury (AKI) caused by myocardial ischemia reperfusion (MI/R), and this renal injury can be resolved notably by dexmedetomidine. Endoplasmic reticulum (ER) stress was reported to get involved in organ injury including AKI.

Objectives: The current study aimed to address the correlation between MI/R induced AKI with ER stress and to assess the effects of dexmedetomidine pretreatment on AKI protection. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118004DOI Listing