77,573 results match your criteria Acute Renal Failure


Maternal Outcomes by Race during Postpartum Readmissions.

Am J Obstet Gynecol 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY. Electronic address:

Background: Maternal race may be an important risk factor for postpartum readmissions and associated adverse outcomes.

Objective: To determine the association of race with serious complications during postpartum readmissions.

Study Design: This repeated cross sectional analysis utilized the National (Nationwide) Inpatient Sample from the Healthcare Cost and Utilization Project from 2012 to 2014. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.016DOI Listing
February 2019

Gastrostomy tubes appear to be safe following pediatric orthotopic heart transplant.

Pediatr Transplant 2019 Feb 20:e13374. Epub 2019 Feb 20.

Division of Pediatric Surgery, Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.

Background: Gastrostomy tube (GT) placement is a common pediatric surgical procedure typically indicated for oral aversion. This may develop in patients with congenital heart disease (CHD) who require an orthotopic heart transplant (OHT). The safety profile of GT placement in OHT patients who are immunosuppressed is unknown. Read More

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http://doi.wiley.com/10.1111/petr.13374
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http://dx.doi.org/10.1111/petr.13374DOI Listing
February 2019
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Sexual dimorphism of acute doxorubicin-induced nephrotoxicity in C57Bl/6 mice.

PLoS One 2019 20;14(2):e0212486. Epub 2019 Feb 20.

Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, United States of America.

Doxorubicin (DOX) is a chemotherapeutic agent that has been reported to cause nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female rodents have been shown to be protected against several features of DOX-induced nephrotoxicity. Nevertheless, the underlying mechanisms of this sexual dimorphism are not fully elucidated. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212486PLOS
February 2019

Timing of Renal Replacement Therapy for Severe Acute Kidney Injury in Critically Ill Patients.

Am J Respir Crit Care Med 2019 Feb 20. Epub 2019 Feb 20.

Hôpital Louis Mourier, Réanimation Médico-Chirurgicale, Colombes, France ;

Acute kidney injury (AKI) affects many intensive care unit patients and is responsible for increased morbidity and mortality. Although life-saving in many situations, renal replacement therapy (RRT) may be associated with complications and the appropriate timing of its initiation is still the subject of intense debate. An early initiation strategy can prevent some metabolic complications whereas a delayed one may allow for renal function recovery in some patients without need for this costly and potentially dangerous technique. Read More

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https://www.atsjournals.org/doi/10.1164/rccm.201810-1906CP
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http://dx.doi.org/10.1164/rccm.201810-1906CPDOI Listing
February 2019
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[Indicators of kidney damage in patients with multiple myeloma in the process of chemotherapeutic treatment.]

Klin Lab Diagn 2018 ;63(12):741-749

Rostov Research Institute of Oncology, Rostov-on-Don, Russia.

The purpose was to study the level of acute kidney injury markers cystatin C, KIM-1, IL-18, NGAL and L-FABR in the blood and urine of patients with the initially identified secreting multiple myeloma (MM) before and during chemotherapeutic treatment. The content of renal markers was examined by ELISA using commercial kits. The study included 23 patients with MM who received 6-8 21-day cycles of chemotherapy (CT) according to the VCD scheme. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-12-741-749DOI Listing
January 2018

[Renal risks of NSAIDs in endurance sports].

Rev Med Suisse 2019 Feb;15(639):444-447

Faculté de médecine, Université de Genève, 1205 Genève 4.

Endurance athletes, either professional or amateur, are consuming non steroidal anti-inflammatory drugs (NSAIDs) during their training and races. The goal is to decrease pain or to prevent a potential pain. These athletes, especially, the amateurs, do not do not know the side effects and have no medical supervision. Read More

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February 2019

[Hepatorenal syndrome : something new?]

Rev Med Suisse 2019 Feb;15(639):432-435

Service de néphrologie, HUG, 1211 Genève 14.

Hepatorenal syndrome is a serious and frequent complication in patients suffering from liver cirrhosis. Its most severe type is characterized by the rapid occurrence of a functional acute kidney injury. However it is mainly an exclusion diagnosis. Read More

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February 2019

EVALUATION OF THE BEHAVIOR OF LEVELS OF HMGB1 AND IL6 AS PREDICTORS OF INFECTION, ACUTE KIDNEY INJURY AND MORTALITY IN CIRRHOTIC PATIENTS WITH VARICEAL BLEEDING.

Arq Gastroenterol 2018 Oct-Dec;55(4):338-342

Universidade Federal de Minas Gerais, Hospital das Clínicas, Belo Horizonte, MG, Brasil.

Background: Gastroesophageal varices and associated bleeding are a major cause of morbidity and mortality in cirrhotic patients.

Objective: To evaluate the potential role of the biomarkers HMGB1 (High Mobility Group Box 1) and IL-6 (Interleukin-6) as predictors of infection, acute kidney injury and mortality in these patients.

Methods: It is a prospective, observational study that included 32 cirrhotic patients with variceal bleeding. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-75DOI Listing

Near-infrared spectroscopy parameters in patients undergoing continuous venovenous hemodiafiltration.

Einstein (Sao Paulo) 2019 Feb 14;17(1):eAO4439. Epub 2019 Feb 14.

Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.

Objective: To investigate the impacts of continuous venovenous hemodiafiltration on the microcirculation in patients with acute kidney injury.

Methods: A prospective observational pilot study conducted in a 40-bed, open clinical-surgical intensive care unit of a private tertiary care hospital located in the city of São Paulo (SP), Brazil. Microcirculation was assessed using near-infrared spectroscopy by means of a 15mm probe placed over the thenar eminence. Read More

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http://dx.doi.org/10.31744/einstein_journal/2019AO4439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377084PMC
February 2019

Time dependent p53 inhibition determines senescence attenuation and long term outcome after renal ischemia/reperfusion.

Am J Physiol Renal Physiol 2019 Feb 20. Epub 2019 Feb 20.

Children's Hospital, Medical School Hannover, Germany.

Inhibition of p53 has been shown to be an efficient strategy for ameliorating kidney ischemia/reperfusion (I/R) injury in experimental models. The therapeutic value of p53 siRNA based inhibition for I/R in renal transplantation is currently evaluated in clinical studies. While the major rationale for these studies is the suppression of pro-apoptotic properties, there are more, equally important injury response pathways regulated by p53. Read More

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http://dx.doi.org/10.1152/ajprenal.00333.2018DOI Listing
February 2019

Physiological effects of altering oxygenation during kidney normothermic machine perfusion.

Am J Physiol Renal Physiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Surgery, University of Cambridge.

Kidney normothermic machine perfusion (NMP) has historically employed a 95% O/5% CO gas mixture. Using a porcine model of organ retrieval, NMP and reperfusion, we tested the hypothesis that reducing perfusate oxygenation (PO) would be detrimental to renal function and cause injury. In a minimal-ischemic-injury (MI) experiment, kidneys sustained 10min of warm ischemia (WI) and 2hr of static cold storage (SCS) before 1hr of NMP with either 95%, 25% or 12% O with 5% CO and N balance. Read More

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http://dx.doi.org/10.1152/ajprenal.00178.2018DOI Listing
February 2019

Angiotensin II and salt-induced decompensation in Balb/CJ mice is aggravated by fluid retention related to low oxidative stress.

Am J Physiol Renal Physiol 2019 Feb 20. Epub 2019 Feb 20.

Department of medical cellbiology, Uppsala Universitet, Sweden.

Aim: Balb/CJ mice are more sensitive to treatment with Angiotensin II (AngII) and high salt (Salt) diet compared to C57BL/6J. Together with higher mortality, they develop edema, signs of heart failure and acute kidney injury. The aim of the present study was to identify differences in renal gene regulation that may affect kidney function and fluid balance, which could contribute to decompensation in Balb/CJ after AngII+Salt treatment. Read More

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http://dx.doi.org/10.1152/ajprenal.00483.2018DOI Listing
February 2019

Morin has protective potential against ER stress induced apoptosis in renal proximal tubular HK-2 cells.

Biomed Pharmacother 2019 Feb 19;112:108659. Epub 2019 Feb 19.

Division of Applied Medicine, School of Korean Medicine, Pusan National University, Yangsan-si 50612, Republic of Korea. Electronic address:

ER stress is an early event of acute kidney injury and has been linked to accelerate the development of chronic kidney disease. Therefore, the compounds that can mimic ER stress inhibitor may confer regulatory effects on ER stress induced apoptosis. In this study, we investigated the protective effects of flavonoid morin against ER stress induced apoptosis in human renal proximal tubular HK-2 cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183321
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http://dx.doi.org/10.1016/j.biopha.2019.108659DOI Listing
February 2019
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Executive summary for the 2015 Annual Data Report of the China Kidney Disease Network (CK-NET).

Kidney Int 2019 Mar;95(3):501-505

Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China; Peking-Tsinghua Center for Life Sciences, Beijing, China.

Chronic kidney disease (CKD) has received increased attention as a leading public health problem worldwide. Globally surveillance systems for kidney disease are still lacking, especially in developing countries like China, which constitutes an obstacle to develop effective preventive strategies. China Kidney Disease Network (CK-NET) was initiated in 2014 and further developed in accordance with the national strategy of prompting Big Data application in China. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183081
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http://dx.doi.org/10.1016/j.kint.2018.11.011DOI Listing
March 2019
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DAMPening sterile inflammation of the kidney.

Kidney Int 2019 Mar;95(3):489-491

Institute of Experimental Immunology, University Clinic of Bonn, Rheinische Friedrich Wilhelm University, Bonn, Germany. Electronic address:

Renal ischemia reperfusion injury (IRI) is a serious cause of acute kidney injury (AKI). Danger-associated-molecular pattern molecules (DAMPs) are thought to promote IRI by initiating immune cell infiltration and driving disease progression, but the underlying pathophysiological mechanisms are mainly unclear. Poluzzi et al. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.007DOI Listing

Impact of Short-Term Complications on Mortality and Quality of Life After Transcatheter Aortic Valve Replacement.

JACC Cardiovasc Interv 2019 Feb;12(4):362-369

Saint Luke's Mid America Heart Institute and University of Missouri-Kansas City, Kansas City, Missouri.

Objectives: The aim of this study was to examine the independent association of short-term complications of transcatheter aortic valve replacement (TAVR) with survival and quality of life at 1 year.

Background: Prior studies have examined the mortality and cost implications of various complications of TAVR. However, many of these complications may primarily affect patients' quality of life after TAVR, which has not been previously studied. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19368798183229
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http://dx.doi.org/10.1016/j.jcin.2018.11.008DOI Listing
February 2019
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Therapeutic Opportunities for Hepcidin in Acute Care Medicine.

Crit Care Clin 2019 Apr 30;35(2):357-374. Epub 2019 Jan 30.

La Jolla Pharmaceutical Company, 4550 Towne Centre Court, San Diego, CA 92121, USA; Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

Iron homeostasis is often disrupted in acute disease with an increase in catalytic free iron leading to the formation of reactive oxygen species and subsequent tissue-specific oxidative damage. This article highlights the potential therapeutic benefit of exogenous hepcidin to prevent and treat iron-induced injury, specifically in the management of infection from enteric gram-negative bacilli or fungi, malaria, sepsis, acute kidney injury, trauma, transfusion, cardiopulmonary bypass surgery, and liver disease. Read More

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http://dx.doi.org/10.1016/j.ccc.2018.11.014DOI Listing

Classic and Nonclassic Renin-Angiotensin Systems in the Critically Ill.

Crit Care Clin 2019 Apr 28;35(2):213-227. Epub 2019 Jan 28.

Department of Medicine, University of Melbourne, Austin Health, Austin Hospital, 145 Studley Road, Heidelberg, Victoria 3084, Australia.

Classic and nonclassic renin-angiotensin systems (RAS) are 2 sides of an ubiquitous endocrine/paracrine cascade regulating blood pressure and homeostasis. Angiotensin II and angiotensin-converting enzyme (ACE) levels are associated with severity of disease in the critically ill, and are central to the physiology and the pathogenesis of circulatory shock. Angiotensin (1-7) and ACE2 act as an endogenous counterregulatory arm to the angiotensin II/ACE axis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07490704183077
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http://dx.doi.org/10.1016/j.ccc.2018.11.002DOI Listing
April 2019
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Burden, access and disparities in kidney disease.

J Ren Care 2019 Mar;45(1):4-8

Faculty of Medicine, Nephrology Unit, Department of Internal Medicine, Cairo University, Giza, Egypt.

Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world. In many settings, rates of kidney disease and the provision of its care are defined by socio-economic, cultural and political factors leading to significant disparities. Read More

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http://dx.doi.org/10.1111/jorc.12269DOI Listing

Clinical practice guideline for renal hypouricemia (1st edition).

Hum Cell 2019 Feb 19. Epub 2019 Feb 19.

Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.

Renal hypouricemia (RHUC) is a disease caused by dysfunction of renal urate reabsorption transporters; however, diagnostic guidance and guidelines for RHUC have been lacking, partly due to the low evidence level of studies on RHUC. This review describes a world-first clinical practice guideline (CPG) and its first version in English for this condition. It was developed following the "MINDS Manual for Guideline Development" methodology, which prioritizes evidence-based medicine. Read More

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http://link.springer.com/10.1007/s13577-019-00239-3
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http://dx.doi.org/10.1007/s13577-019-00239-3DOI Listing
February 2019
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Propolis and Its Combination with Boric Acid Protect Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Inhibiting Oxidative Stress, Inflammation, DNA Damage, and Apoptosis in Rats.

Biol Trace Elem Res 2019 Feb 19. Epub 2019 Feb 19.

Department of Chemistry, Faculty of Science, Dokuz Eylül University, Izmir, Turkey.

Ischemia reperfusion (I/R) injury which causes kidney dysfunction is one of the most studied diseases directly linked to oxidative stress. In this regard, it is important to protect cells against damage by inducing antioxidant response. Herein, we aimed to evaluate the therapeutic roles and possible mechanisms of propolis and boric acid in kidney I/R injury based on relevant basic research and clinical studies. Read More

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http://dx.doi.org/10.1007/s12011-019-1649-2DOI Listing
February 2019

Effect of Sheng-jiang powder on multiple-organ inflammatory injury in acute pancreatitis in rats fed a high-fat diet.

World J Gastroenterol 2019 Feb;25(6):683-695

Department of Integrative Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: Obesity worsens inflammatory organ injury in acute pancreatitis (AP), but there is no effective preventive strategy. Sheng-jiang powder (SJP) has been shown to alleviate multiple-organ inflammatory injury in rats with high-fat diet-induced obesity. Hence, SJP is supposed to have an effect on multiple-organ inflammatory injury in AP in rats fed a high-fat diet. Read More

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http://dx.doi.org/10.3748/wjg.v25.i6.683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378539PMC
February 2019

Analysis of postmarketing safety data for proton-pump inhibitors reveals increased propensity for renal injury, electrolyte abnormalities, and nephrolithiasis.

Sci Rep 2019 Feb 19;9(1):2282. Epub 2019 Feb 19.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, 92093-0747, USA.

Proton pump inhibitors, PPIs, are widely prescribed and sold globally. Although initially intended for time-limited treatment of acute disorders, such as gastric ulcers and esophagitis, PPIs are now commonly used for prolonged durations and are considered safe for over the counter access. Recent studies have raised concern over associations between PPI use and acute kidney injury, chronic kidney disease, end-stage renal disease, and electrolyte abnormalities. Read More

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http://www.nature.com/articles/s41598-019-39335-7
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http://dx.doi.org/10.1038/s41598-019-39335-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381091PMC
February 2019
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Mitochondrial Haplogroup and the Risk of Acute Kidney Injury Following Cardiac Bypass Surgery.

Sci Rep 2019 Feb 19;9(1):2279. Epub 2019 Feb 19.

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.

Although mitochondrial dysfunction plays a key role in the pathophysiology of acute kidney injury (AKI), the influence of mitochondrial genetic variability in this process remains unclear. We explored the association between the risk of post-cardiac bypass AKI and mitochondrial haplotype - inherited mitochondrial genomic variations of potentially functional significance. Our single-centre study recruited consecutive patients prior to surgery. Read More

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http://dx.doi.org/10.1038/s41598-018-37944-2DOI Listing
February 2019

Burden, Access, and Disparities in Kidney Disease.

Nephron 2019 Feb 18:1-8. Epub 2019 Feb 18.

Nephrology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.

Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world. In many settings, rates of kidney disease and the provision of its care are defined by socioeconomic, cultural, and political factors leading to significant disparities. Read More

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http://dx.doi.org/10.1159/000495557DOI Listing
February 2019

Reversal Unilateral Ureteral Obstruction: A Mice Experimental Model.

Nephron 2019 Feb 15:1-10. Epub 2019 Feb 15.

Experimental Nephrology, Department of Ciències Clíniques, Universitat de Barcelona, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Hospitalet de Llobregat, Barcelona,

Background/aims: Reversible unilateral ureteral obstruction (R-UUO) is a model of renal injury used to study the structural and functional recovery of the kidneys after relief of the obstruction. This model has a prominent potential for the study of inflammatory and immune processes, cellular and tissue regeneration. Here we sought to describe a model of renal injury and repair R-UUO in mice. Read More

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http://dx.doi.org/10.1159/000497119DOI Listing
February 2019

Incidence of Acute Kidney Injury in Critically Ill Patients Receiving Vancomycin with Concomitant Piperacillin/Tazobactam, Cefepime, or Meropenem.

Antimicrob Agents Chemother 2019 Feb 19. Epub 2019 Feb 19.

Department of Pharmacy, Barnes-Jewish Hospital, St. Louis, MO

Critically ill patients are frequently treated with empiric antibiotic therapy including vancomycin and β-Lactams. Recent evidence suggests an increased risk of acute kidney injury (AKI) in patients who received the combination of vancomycin and piperacillin/tazobactam (VPT) compared with patients who received vancomycin alone or vancomycin in combination with cefepime (VC) or meropenem (VM), but most studies have been conducted predominately in the non-critically ill population. A retrospective cohort study including 2492 patients was conducted in the intensive care units of a large university hospital with the primary outcome being the development of any AKI. Read More

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http://dx.doi.org/10.1128/AAC.02658-18DOI Listing
February 2019

Platelet-to-lymphocyte ratio as a prognostic predictor of mortality for sepsis: interaction effect with disease severity-a retrospective study.

BMJ Open 2019 Jan 25;9(1):e022896. Epub 2019 Jan 25.

Department of Intensive Care Unit, Dongyang People's Hospital, Jinhua, P.R. China.

Objective: The role of platelet-to-lymphocyte ratio (PLR) as an indicator of inflammation has been the focus of research recently. We aimed to investigate the value of PLR for sepsis.

Design: A retrospective cohort study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022896DOI Listing
January 2019

Impact of renal dysfunction on the management and outcome of acute heart failure: results from the French prospective, multicentre, DeFSSICA survey.

BMJ Open 2019 Jan 15;9(1):e022776. Epub 2019 Jan 15.

Emergency Department and RESCUe Network, Lucien Hussel Hospital, Vienne, France.

Objectives: Cardiorenal syndrome (CRS) is the combination of acute heart failure syndrome (AHF) and renal dysfunction (creatinine clearance (CrCl) ≤60 mL/min). Real-life data were used to compare the management and outcome of AHF with and without renal dysfunction.

Design: Prospective, multicentre. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340446PMC
January 2019

Impact of acute renal failure on plasmatic levels of cleaved endocan.

Crit Care 2019 Feb 19;23(1):55. Epub 2019 Feb 19.

Univ. Lille, U1019 - UMR 8204 - CIIL - Center for Infection and Immunity of Lille, F-59000, Lille, France.

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http://dx.doi.org/10.1186/s13054-019-2349-1DOI Listing
February 2019

Authors' response to letter "Prediction of acute kidney injury in intensive care unit patients".

Crit Care 2019 Feb 19;23(1):58. Epub 2019 Feb 19.

Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Dengakugakubo, Toyoake, 470-1192, Japan.

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http://dx.doi.org/10.1186/s13054-019-2340-xDOI Listing
February 2019

Response to "Are fluids resuscitation the "Keyser Soze" of acute kidney injury in trauma patients?"

Crit Care 2019 Feb 19;23(1):59. Epub 2019 Feb 19.

Department of Anesthesiology and Critical Care, Bicêtre Hôpitaux Universitaires Paris Sud, Université Paris Saclay, AP-HP, 78 Rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France.

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http://dx.doi.org/10.1186/s13054-019-2344-6DOI Listing
February 2019

The Role of Osteopontin as a Diagnostic and Prognostic Biomarker in Sepsis and Septic Shock.

Cells 2019 Feb 18;8(2). Epub 2019 Feb 18.

CAAD, IRCAD, Department of Health Sciences, Università degli Studi del Piemonte Orientale, Corso Trieste 15, 28100 Novara (NO), Piedmont, Italy.

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host-response to infections. Osteopontin (OPN) is an extracellular matrix protein involved in the inflammatory response. Our aim was to evaluate the diagnostic and prognostic performance in sepsis of a single OPN determination in the Emergency Department (ED). Read More

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http://dx.doi.org/10.3390/cells8020174DOI Listing
February 2019

Comparison of 30-Day MACE between Immediate versus Staged Complete Revascularization in Acute Myocardial Infarction with Multivessel Disease, and the Effect of Coronary Lesion Complexity.

Medicina (Kaunas) 2019 Feb 15;55(2). Epub 2019 Feb 15.

Department of Cardiology, Kosuyolu Heart Education and Research Hospital, University of Health Sciences, 34844 Istanbul, Turkey.

In patients with acute myocardial infarction and multivessel disease, the timing of intervention to non-culprit lesions is still a matter of debate, especially in patients without shock. This study aimed to compare the effect of multivessel intervention, performed at index percutaneous coronary intervention (PCI) (MVI-I) or index hospitalization (MVI-S), on the 30-day results of acute myocardial infarction (AMI), and to investigate the effect of coronary lesion complexity assessed by the Syntax (Sx) score on the timing of multivessel intervention. We enrolled 180 patients with MVI-I, and 425 patients with MVI-S. Read More

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http://dx.doi.org/10.3390/medicina55020051DOI Listing
February 2019

Role of therapeutic plasma exchange in snake bite associated thrombotic microangiopathy-A case report with review of literature.

J Clin Apher 2019 Feb 19. Epub 2019 Feb 19.

Department of Immunohematology and Blood Transfusion, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Post snake bite renal failure due to thrombotic microangiopathy (TMA) is often overlooked and not considered as a separate entity while managing the patient. This case report highlights the efficacy of Therapeutic Plasma Exchange in managing the post envenomation TMA. Anti-snake venom was administered following severe hematotoxic envenomation, but later on developed acute kidney injury and hence hemodialysis was done for 2 days without much improvement. Read More

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http://dx.doi.org/10.1002/jca.21691DOI Listing
February 2019

Characterization of Early Hepatic Injury in HCV-Negative Recipients of HCV-Infected Kidneys.

Clin Transplant 2019 Feb 19:e13494. Epub 2019 Feb 19.

Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, Philadelphia, PA.

Recent data demonstrate that transplanting kidneys from hepatitis C virus (HCV)-infected donors could increase the number of kidney transplants (KT) by 500-1,000 per year with durable cure rates and excellent 1-year renal function. However, data on the risks of acute donor-derived HCV are limited, hampering our ability to inform patients and providers. We sought to examine data from a trial of transplanting HCV-negative patients with kidneys from HCV-infected donors (THINKER, NCT #02743897) to determine whether these recipients had a greater likelihood of having early alanine aminotransferase (ALT) elevations versus comparator recipients of kidneys from HCV-negative donors. Read More

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http://dx.doi.org/10.1111/ctr.13494DOI Listing
February 2019

Proton pump inhibitors and risk of acute and chronic kidney disease: a retrospective cohort study.

Pharmacotherapy 2019 Feb 18. Epub 2019 Feb 18.

Department of Pharmacy Practice, University at Buffalo School of Pharmacy and Pharmaceutical Sciences, Buffalo, NY.

Background: Proton pump inhibitors (PPIs) have been linked to acute kidney injury (AKI) and chronic kidney disease (CKD); however, current evidence has only been evaluated in a small number of studies with short follow-up periods. This study examined the association between PPI use and risk of incident AKI and CKD in a large, population-based health-maintenance organization (HMO) cohort.

Methods: Patients aged 18 years or older, without evidence of pre-existing renal disease, started on PPI therapy, and continuously enrolled for at least 12 months between July 1993 and September 2008 were identified in an HMO database. Read More

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http://dx.doi.org/10.1002/phar.2235DOI Listing
February 2019

Predictors of withdrawal from renal replacement therapy among patients with acute kidney injury requiring renal replacement therapy.

Clin Exp Nephrol 2019 Feb 16. Epub 2019 Feb 16.

Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, 4-23-15 Kotobashi, Sumida-ku, Tokyo, 130-8575, Japan.

Background: Although recovery of renal function after an episode of acute kidney injury (AKI) is an important clinical measure of morbidity, predictors of withdrawal from renal replacement therapy (RRT) among AKI patients remain unclear.

Methods: In this single-center retrospective cohort study, we examined the clinical records of AKI patients requiring RRT who were hospitalized in the ICU or general wards at our hospital from January 2010 to December 2013. A priori-determined covariates of age, sex, cardiovascular disease, chronic kidney disease (CKD), mean arterial pressure (MAP), sepsis, nephrotoxic agents, and hypoalbuminemia were assessed in Cox hazard models to estimate hazard ratio (HR). Read More

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http://dx.doi.org/10.1007/s10157-019-01711-yDOI Listing
February 2019

Acute Respiratory Failure in Renal Transplant Recipients: A Single Center Experience.

Exp Clin Transplant 2019 Jan;17(Suppl 1):172-174

From the Pulmonary Medicine, Baskent University, Adana, Turkey.

Objectives: We evaluated the frequency and cause of acute respiratory failure in renal transplant recipients.

Materials And Methods: Our single-center retrospective observational study included consecutive renal transplant recipients who were admitted to an intensive care unit for acute respiratory failure between 2011 and 2017. Acute respiratory failure was defined as oxygen saturation < 92% or partial pressure of oxygen in arterial blood < 60 mm Hg on room air and/or requirement of noninvasive or invasive mechanical ventilation. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P49DOI Listing
January 2019
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Effects of Different Volatile Anesthetics on Cytokine and Chemokine Production After Ischemia-Reperfusion Injury in Patients Undergoing Living-Donor Kidney Transplant.

Exp Clin Transplant 2019 Jan;17(Suppl 1):68-74

From the Department of Anesthesiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.

Objectives: Renal transplant is the treatment of choice for patients with end-stage renal disease. Ischemiareperfusion damage is a major cause of early renal dysfunction during the perioperative period. Ischemic hypoxic damage increases local inflammation, leading to secretion of cytokines and chemokines. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.O10DOI Listing
January 2019

Comparison of the Transarterial and Transthoracic Approaches in Nontransfemoral Transcatheter Aortic Valve Implantation.

Am J Cardiol 2019 Feb 8. Epub 2019 Feb 8.

University of Rennes 1, Cardiac, Thoracic, and Vascular Surgery Department, Pontchaillou University Hospital, Signal and Image Treatment laboratory (LTSI), National Institute of Health and Medical Research U1099, Rennes, France.

Transfemoral approach stands as the reference access-route for transcatheter aortic valve implantation (TAVI). Nonetheless, alternatives approaches are still needed in a significant proportion of patients. This study aimed at comparing outcomes between transthoracic-approach (transapical or transaortic) and transarterial-approach (transcarotid or subclavian) TAVI. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.040DOI Listing
February 2019

Intestinal Toll-like receptor 9 deficiency leads to Paneth cell hyperplasia and exacerbates kidney, intestine, and liver injury after ischemia/reperfusion injury.

Kidney Int 2019 Feb 15. Epub 2019 Feb 15.

Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York, USA. Electronic address:

Intestinal Paneth cells play a critical role in ischemic acute kidney injury (AKI) by releasing interleukin 17A (IL-17A). Because Toll-like receptor 9 (TLR9) activation degranulates Paneth cells and necrotic tubular epithelial cells release several damage associated molecular patterns that target TLR9, we tested the hypothesis that intestinal TLR9 deficiency would protect against ischemic AKI and associated remote intestinal and hepatic dysfunction by decreasing Paneth cell degranulation. We generated mice lacking TLR9 in intestinal epithelia (TLR9fl/fl Villin Cre mice) and compared them to wild type (TLR9fl/fl) mice following right nephrectomy and left ischemia/reperfusion. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.035DOI Listing
February 2019

Point of care creatinine testing in diagnostic imaging: A feasibility study within the outpatient computed tomography setting.

Eur J Radiol 2019 Mar 8;112:82-87. Epub 2019 Jan 8.

Mid Yorkshire NHS Hospitals Trust, Wakefield, UK.

Introduction: Although the risks associated with iodinated contrast administration are acknowledged to be very low, screening of kidney function prior to administration is still standard practice in many hospitals. This study has evaluated the feasibility of implementing a screening form in conjunction with point of care (PoC) creatinine testing as a method to manage the risks of post contrast acute kidney injury (PC-AKI) within the CT imaging pathway.

Method: Over an eight-week period 300 adult outpatients attending a UK CT department for contrast-enhanced scans were approached. Read More

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http://dx.doi.org/10.1016/j.ejrad.2019.01.007DOI Listing

Chemometric analysis of Amaranthus retroflexus in relation to livestock toxicity in southern Australia.

Phytochemistry 2019 Feb 15;161:1-10. Epub 2019 Feb 15.

Graham Centre for Agricultural Innovation (Charles Sturt University and NSW Department of Primary Industries), Wagga Wagga, NSW, 2650, Australia; Charles Sturt University, School of Agricultural and Wine Sciences, Wagga Wagga, NSW, 2678, Australia.

Amaranthus retroflexus L., an introduced invasive weed in southern Australia, has been associated with acute renal failure and/or mortality in a number of livestock species. While its leaves, flowers and stems are generally reported to contain high levels of nitrogen, few studies have fully characterised the chemical composition of A. Read More

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http://dx.doi.org/10.1016/j.phytochem.2019.01.016DOI Listing
February 2019

A Single-Center Retrospective Study of Acute Kidney Injury Incidence in Patients With Advanced Malignancies Treated With Antimitochondrial Targeted Drug.

Kidney Int Rep 2019 Feb 29;4(2):310-320. Epub 2018 Oct 29.

Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

Introduction: Mitochondrial dysfunction plays an important role in the pathophysiology of kidney disease. Inhibitors of mitochondrial metabolism are being developed for the treatment of solid organ and hematologic malignancies. We describe the incidence and clinical features of acute kidney injury (AKI) in patients treated with the antimitochondrial drug CPI-613. Read More

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http://dx.doi.org/10.1016/j.ekir.2018.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365364PMC
February 2019

Giant Gastroschisis with Complete Liver Herniation: A Case Report of Two Patients.

Case Rep Surg 2019 15;2019:4136214. Epub 2019 Jan 15.

Department of General Surgery, Boston Children's Hospital, 300 Longwood Ave, Fegan 3, Boston MA 20115, USA.

Introduction: There are no reported survivors of gastroschisis with complete liver herniation. We describe a case report of two patients, one of whom survived.

Case #1: The patient was born with gastroschisis and herniation of the entire liver. Read More

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http://dx.doi.org/10.1155/2019/4136214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350565PMC
January 2019

Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab.

Case Rep Nephrol 2019 15;2019:3614980. Epub 2019 Jan 15.

Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Immune-checkpoint-inhibitors (ICPIs) represent a novel class of immunotherapy against several malignancies. These agents are associated with several "immune-mediated" adverse effects, but the reported renal toxicity of ICPIs is less well defined. We present the case of a 60-year-old man with a history of non-small cell lung cancer, who developed acute kidney injury (AKI) approximately 3. Read More

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http://dx.doi.org/10.1155/2019/3614980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350541PMC
January 2019

Pharmacological interventions for the prevention of contrast-induced acute kidney injury in high-risk adult patients undergoing coronary angiography: a systematic review and meta-analysis of randomised controlled trials.

Open Heart 2019 25;6(1):e000864. Epub 2019 Jan 25.

Imperial College Trial Unit and Division of Surgery and Cancer, Imperial College London, St. Mary's Hospital, London, UK.

Objective: Quantify the efficacy of strategies to prevent contrast-induced acute kidney injury (CI-AKI) in high-risk patients undergoing coronary angiography (CAG) with or without percutaneous coronary intervention (PCI).

Background: CI-AKI remains a common problem. The renoprotective efficacy of existing pharmacological agents remains uncertain in high-risk populations. Read More

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http://dx.doi.org/10.1136/openhrt-2018-000864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350720PMC
January 2019

HO-1 concentrations 24 hours after cardiac surgery are associated with the incidence of acute kidney injury: a prospective cohort study.

Int J Nephrol Renovasc Dis 2019 23;12:9-18. Epub 2019 Jan 23.

Department of Cardiovascular Surgery, University Hospital Würzburg, Würzburg, Germany,

Background: Acute kidney injury (AKI) is a serious complication after cardiac surgery that is associated with increased mortality and morbidity. Heme oxygenase-1 (HO-1) is an enzyme synthesized in renal tubular cells as one of the most intense responses to oxidant stress linked with protective, anti-inflammatory properties. Yet, it is unknown if serum HO-1 induction following cardiac surgical procedure involving cardiopulmonary bypass (CPB) is associated with incidence and severity of AKI. Read More

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http://dx.doi.org/10.2147/IJNRD.S165308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350641PMC
January 2019