92,560 results match your criteria Acute Renal Failure


Carnitine Palmitoyltransferase-II Deficiency: Case Presentation and Review of the Literature.

Rom J Intern Med 2021 Jun 12. Epub 2021 Jun 12.

Department of Internal Medicine, Mayo Clinic, 4500 San Pablo Rd S, Jacksonville, FL 32224.

Carnitine palmitoyltransferase-II deficiency, an autosomal recessive disorder, is the most common cause of recurrent rhabdomyolysis in adults. Recognition and avoidance of triggers, such as heavy exercise and stress, is key in prevention of further episodes; however, even with preventative measures, many patients will continue to experience periodic symptoms, including rhabdomyolysis. Avoidance of renal failure, correction of electrolyte disturbances and halting further muscle breakdown are the goals of treatment. Read More

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Capmatinib-Induced Pseudo-Acute Kidney Injury: A Case Report.

Am J Kidney Dis 2021 Jun 9. Epub 2021 Jun 9.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota. Electronic address:

We present a case of pseudo acute kidney injury (AKI) following capmatinib therapy in an 84-year-old male with combined non-small cell (adenocarcinoma) and small cell lung cancer with MET Exon 14 skipping mutation. His past medical history was significant for chronic kidney disease (CKD) stage 3 with a baseline serum creatinine (SCr) of 1.6 mg/dl rising to 2. Read More

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Ultrafiltration in acute heart failure: Current knowledge and fields for further research.

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Heart Diseases, Wroclaw Medical University, Poland.

Heart failure is one of the leading causes of death in developed countries and remains a significant burden to the healthcare system. Fluid overload is a process responsible for the majority of the heart failure symptoms. Pharmacotherapy is a first-line treatment for this condition; however, due to the phenomenon of diuretic resistance, drug therapy can frequently be insufficient. Read More

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The lethal internal face of the coronaviruses: Kidney tropism of the SARS, MERS, and COVID-19 viruses.

IUBMB Life 2021 Jun 12. Epub 2021 Jun 12.

Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

The kidney is one of the main targets attacked by viruses in patients with a coronavirus infection. Until now, SARS-CoV-2 has been identified as the seventh member of the coronavirus family capable of infecting humans. In the past two decades, humankind has experienced outbreaks triggered by two other extremely infective members of the coronavirus family; the MERS-CoV and the SARS-CoV. Read More

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Unexpected overdose of oral cyclosporine in a kidney transplant patient: a case report.

Eur J Hosp Pharm 2021 Jun 11. Epub 2021 Jun 11.

Univ Rennes, CHU Rennes, Inserm, EHESP, IRSET (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.

Cyclosporine is a widely used immunosuppressive agent to prevent rejection of solid organ transplant. Here, we describe the case of a 71-year-old man who received the prescribed dose of cyclosporine 10 times 6 days after a kidney transplantation because of a concentration miscalculation involving two galenic forms. The patient presented gastrointestinal and neurological disorders. Read More

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Severe Acute Kidney Injury and Mortality in Extremely Low Gestational Age Neonates.

Clin J Am Soc Nephrol 2021 Jun 11;16(6):862-869. Epub 2021 Jun 11.

Division of Nephrology, University of Alabama at Birmingham, Children's of Alabama, Birmingham, Alabama.

Background And Objectives: AKI is associated with poor short- and long-term outcomes. Questions remain about the frequency and timing of AKI, and whether AKI is a cause of death in extremely low gestational age neonates.

Design, Setting, Participants, & Measurements: The Recombinant Erythropoietin for Protection of Infant Kidney Disease Study examines the kidney outcomes of extremely low gestational age neonates enrolled in the Preterm Epo Neuroprotection study, a randomized, placebo-controlled trial of recombinant human erythropoietin. Read More

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Dialyzing Acute Kidney Injury Patients after Hospital Discharge.

Clin J Am Soc Nephrol 2021 Jun 11;16(6):848-849. Epub 2021 Jun 11.

Division of Nephrology, University of California San Francisco School of Medicine, San Francisco, California

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Renal replacement therapy in critically ill patients with acute kidney injury: 2020 nephrologist's perspective.

Nefrologia 2021 Jun 8. Epub 2021 Jun 8.

Servicio de Nefrología, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain; RedinRen RETIC ISCIII 16/009/009. Electronic address:

Renal replacement therapies (RRT) as support for acute kidney injury in critically ill patients have become a routine and essential practice in their management, resulting in the widespread use of various techniques among these patients, such as intermittent hemodialysis (IHD), extended hemodialysis and continuous RRT (CRRT). In this review we aim to summarize current evidence of indication, choice of modality, timing of initiation, dosing and technical aspects of RRT. We carried out a narrative review based on guidelines, consensus documents by main working groups and the latest relevant clinical trials on RRT in the critically ill. Read More

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REVISITING THE ACUTE KIDNEY INJURY IN WISTAR RATS EXPERIMENTALLY ENVENOMATED WITY Bothrops jararacussu VENOM.

Toxicon 2021 Jun 8. Epub 2021 Jun 8.

Programa de Pós-graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil. Electronic address:

There is no consensus on whether serotherapy prevents acute kidney injury (AKI) and there is no pharmacotherapy to impede the disease. We aimed to elaborate an AKI model induced by the administration of Bothrops jararacussu (Bj) venom for preclinical studies. Male Wistar rats were randomly divided into 3 different groups: (1) Bj-IV: intravenous administration of 0. Read More

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Renoprotective effects of levosimendan on acute kidney injury following cardiac arrest via anti-inflammation, anti-apoptosis and ERK activation.

FEBS Open Bio 2021 Jun 11. Epub 2021 Jun 11.

Department of Emergency, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

ATP-sensitive potassium channels (KATPs) have protective effects in ischemia-reperfusion-induced injuries and can be activated by levosimendan. This study investigated the effects of levosimendan on renal injury, inflammation, apoptosis and survival in a rat model of acute kidney injury (AKI) following cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). Rats underwent a 5-minute asphyxia-based CA and resuscitation. Read More

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An overview on the COVID-19 complications in pediatric population: A pandemic dilemma.

Int J Clin Pract 2021 Jun 11:e14494. Epub 2021 Jun 11.

Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

Aim: The primary objective of this article is to understand the various complications caused by the coronavirus in the pediatric population.

Method: An electronic search was conducted using PubMed and incorporated forward and backward research methods on clinical trials, case reports, case series guidelines, and reports from the centre for disease control and prevention (CDC) and the keywords included Covid-19, Paediatrics, Multisystem inflammatory syndrome in children (MIS-C), Complications, Acute kidney injury, Heart failure. Secondary resources included one study from pre-print servers (www. Read More

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Organ failure, aetiology and 7-day all-cause mortality among acute adult patients on arrival to an emergency department: a hospital-based cohort study.

Eur J Emerg Med 2021 Jun 10. Epub 2021 Jun 10.

Department of Emergency Medicine, Odense University Hospital, Odense Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus Department of Public Health, University of Southern Denmark Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense Department of Regional Health Research, University of Southern Denmark Department of Emergency Medicine, Hospital of South West Jutland, Esbjerg Institute of Clinical Research, University of Southern Denmark.

Background: Organ failure is both a frequent and dangerous condition among adult patients on arrival to an emergency department (ED). The risk of an unfavourable outcome could depend on the underlying aetiology. Knowledge of the relation between aetiology and prognosis could improve the risk stratification at arrival. Read More

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Acute Gluteal Compartment Syndrome with Nonclassical Symptoms: A Case Report on an Easily Missed Diagnosis.

JBJS Case Connect 2021 06 11;11(2). Epub 2021 Jun 11.

Department of Orthopaedic Surgery and Rehabilitation, Loyola University Medical Center, Stritch School of Medicine, Maywood, Illinois.

Case: A 34-year-old man presented to the emergency department with rhabdomyolysis, acute kidney injury, and pain in the gluteal region after falling asleep on his side after heroin and alcohol use. On examination, he had swollen gluteal compartment musculature; however, he tolerated full passive range of motion with minimal pain. Intercompartmental pressure measured >110 mm Hg; therefore, emergent fasciotomy of the gluteal compartment musculature was performed. Read More

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Prophylactic dialysis improves short-term clinical outcome in patients with non-dialysis-dependent chronic kidney disease undergoing cardiac surgery: a meta-analysis of randomized controlled trials.

Coron Artery Dis 2021 Jun 10. Epub 2021 Jun 10.

Division of Nephrology, Beijing Anzhen Hospital, Capital Medical University, Beijing, P.R.China.

Background: Several studies have reported that prophylactic dialysis can reduce the mortality of non-dialysis-dependent chronic kidney disease (CKD) patients after cardiac surgery. However, the results of complications in these randomized controlled trials (RCTs) were not consistent. We aimed to perform a meta-analysis to systematically evaluate the effect of prophylactic dialysis in these non-dialysis-dependent CKD patients. Read More

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Validation of a Crisis Standards of Care Model for Prioritization of Limited Resources During the Coronavirus Disease 2019 Crisis in an Urban, Safety-Net, Academic Medical Center.

Crit Care Med 2021 Jun 9. Epub 2021 Jun 9.

Department of Medicine, Section of General Internal Medicine, Boston Medical Center, Boston, MA. Boston University School of Medicine, Boston, MA. Boston Medical Center, Boston, MA. Department of Biostatistics, Boston University School of Public Health, Boston, MA. Department of Medicine, Section of Cardiology, Boston Medical Center, Boston, MA. Department of Medicine, Section of Nephrology, Boston Medical Center, Boston, MA. Department of Neurology, Boston Medical Center, Boston, MA. Department of Medicine, Section of Pulmonary, Allergy, and Critical Care Medicine, Boston Medical Center, Boston, MA. Department of Emergency Medicine, Boston Medical Center, Boston, MA. Department of Medicine, Section of Hematology and Oncology, Boston Medical Center, Boston, MA. Department of Medicine, Section of Gastroenterology, Boston Medical Center, Boston, MA. Department of Pediatrics, Boston Medical Center, Boston, MA. Department of Quality and Patient Safety, Boston Medical Center, Boston, MA. Department of Anesthesiology, Boston Medical Center, Boston, MA. Office of the General Counsel, Boston Medical Center, Boston, MA. Department of Family Medicine, Boston Medical Center, Boston, MA. Department of Medicine, Section of Infectious Disease, Boston Medical Center, Boston, MA. Department of Neurosurgery, Boston Medical Center, Boston, MA.

Objectives: The coronavirus disease 2019 pandemic has overwhelmed healthcare resources even in wealthy nations, necessitating rationing of limited resources without previously established crisis standards of care protocols. In Massachusetts, triage guidelines were designed based on acute illness and chronic life-limiting conditions. In this study, we sought to retrospectively validate this protocol to cohorts of critically ill patients from our hospital. Read More

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Influence of age on gender-related differences in acute kidney injury after minimally invasive radical or partial nephrectomy.

Surg Endosc 2021 Jun 11. Epub 2021 Jun 11.

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Background: Female gender is known to be protective against acute kidney injury (AKI) after radical or partial nephrectomy and estrogen is considered a protective factor. If estrogen is a major contributor to the protective effects of female gender against renal injury, these protective effects may be diminished in postmenopausal women. Therefore, this retrospective study investigated the influence of female age on gender-related differences in AKI after minimally invasive radical or partial nephrectomy. Read More

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Umbrella review of 42 systematic reviews with meta-analyses: the safety of proton pump inhibitors.

Aliment Pharmacol Ther 2021 Jun 11. Epub 2021 Jun 11.

Feinberg School of Medicine at Northwestern University, Chicago, IL, USA.

Background: Proton pump inhibitors (PPIs) are widely used to treat and prevent acid-related disorders. Despite high efficacy, PPI safety has been increasingly scrutinised. However, no comprehensive review summarising investigations of various adverse events is available. Read More

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CIRBP promotes ferroptosis by interacting with ELAVL1 and activating ferritinophagy during renal ischaemia-reperfusion injury.

J Cell Mol Med 2021 Jun 10. Epub 2021 Jun 10.

Department of Organ Transplantation, Shanghai Changhai Hospital, Shanghai, China.

Renal ischaemia-reperfusion (IR) is a major cause of acute kidney injury (AKI). Cold-inducible RNA-binding protein (CIRBP) may contribute to AKI because its deficiency protects against renal IR injury in a mechanism believed to involve ferroptosis. We aimed to investigate whether ferroptosis is associated with CIRBP-mediated renal damage. Read More

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Global REnal Involvement of CORonavirus Disease 2019 (RECORD): A Systematic Review and Meta-Analysis of Incidence, Risk Factors, and Clinical Outcomes.

Front Med (Lausanne) 2021 25;8:678200. Epub 2021 May 25.

Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.

The quantitative effect of underlying non-communicable diseases on acute kidney injury (AKI) incidence and the factors affecting the odds of death among coronavirus disease 2019 (COVID-19) AKI patients were unclear at population level. This study aimed to assess the association between AKI, mortality, underlying non-communicable diseases, and clinical risk factors. A systematic search of six databases was performed from January 1, 2020, until October 5, 2020. Read More

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Urinary Levels of SARS-CoV-2 Nucleocapsid Protein Associate With Risk of AKI and COVID-19 Severity: A Single-Center Observational Study.

Front Med (Lausanne) 2021 25;8:644715. Epub 2021 May 25.

Department of Nephrology and Rheumatology, University Medical Center Göttingen, Göttingen, Germany.

Acute kidney injury (AKI) is very common in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease 2019 (COVID-19) and considered as a risk factor for COVID-19 severity. SARS-CoV-2 renal tropism has been observed in COVID-19 patients, suggesting that direct viral injury of the kidneys may contribute to AKI. We examined 20 adult cases with confirmed SARS-CoV-2 infection requiring ICU supportive care in a single-center prospective observational study and investigated whether urinary markers for viral infection (SARS-CoV-2 N) and shedded cellular membrane proteins (ACE2, TMPRSS2) allow identification of patients at risk for AKI and outcome of COVID-19. Read More

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A Prospective Investigation of Bispecific CD19/22 CAR T Cell Therapy in Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphoma.

Front Oncol 2021 25;11:664421. Epub 2021 May 25.

Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: The use of T cells expressing chimeric antigen receptor (CAR T) engineered to target CD19 constitutes breakthrough treatment for relapsed or refractory B cell non-Hodgkin lymphoma (R/R B-NHL). Despite improved outcomes, high relapse rate remains a challenge to overcome. Here, we report the clinical results and the pharmacokinetics of bispecific CD19/22 CAR T in patients with R/R B-NHL. Read More

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Acute kidney disease in hospitalized acute kidney injury patients.

PeerJ 2021 24;9:e11400. Epub 2021 May 24.

Department of Nephrology, The Second Xiangya Hospital of Central South University; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China.

Background: Acute kidney injury (AKI) and chronic kidney disease (CKD) have become worldwide public health problems, but little information is known about the epidemiology of acute kidney disease (AKD)-a state in between AKI and CKD. We aimed to explore the incidence and outcomes of hospitalized patients with AKD after AKI, and investigate the prognostic value of AKD in predicting 30-day and one-year adverse outcomes.

Methods: A total of 2,556 hospitalized AKI patients were identified from three tertiary hospitals in China in 2015 and followed up for one year. Read More

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Utilization of Echocardiography After Acute Kidney Injury Was Associated with Improved Outcomes in Patients in Intensive Care Unit.

Int J Gen Med 2021 1;14:2205-2213. Epub 2021 Jun 1.

Department of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan, 430061, People's Republic of China.

Background: We aimed to investigate the association between usage of transthoracic echocardiography (TTE) within 24 hours after acute kidney injury (AKI) and the prognosis of patients in intensive care unit (ICU).

Methods: The Medical Information Mart for Intensive Care III (MIMIC-III) database was used to identify AKI patients with and without TTE administration. The primary outcome was 28-day mortality. Read More

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Viral Nephropathies, Adding SARS-CoV-2 to the List.

Int J Nephrol Renovasc Dis 2021 3;14:157-164. Epub 2021 Jun 3.

Division of Nephrology, Department of Internal Medicine, Joan C Edwards Marshall University School of Medicine, Huntington, WV, USA.

Viral infections in the immunocompetent host can cause both acute and chronic kidney disease either as a direct damage to the infected kidney cells or as a consequence of systemic immune responses that impact kidney function. Since identifying these entities in the 1970s and 80s, major breakthroughs in the understanding of the viral mechanisms have occurred. Viruses have evolved mechanisms to hijack signaling pathways of infected cells to evade antiviral immune responses by the host. Read More

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Human Kidney Spheroids and Monolayers Provide Insights into SARS-CoV-2 Renal Interactions.

J Am Soc Nephrol 2021 Jun 10. Epub 2021 Jun 10.

B Dekel, Pediatric Stem Cell Research Institute, Edmond and Lily Sara Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel

Although coronavirus disease 2019 (COVID-19) causes significant morbidity, mainly from pulmonary involvement, extrapulmonary symptoms are also major components of the disease. Kidney disease, usually presenting as acute kidney injury (AKI), is particularly severe among patients with COVID-19. It is unknown, however, whether such injury results from direct kidney infection with COVID-19's causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or from indirect mechanisms. Read More

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Acute kidney injury in hospitalized patients with COVID-19: A Portuguese cohort.

Nefrologia 2021 May 14. Epub 2021 May 14.

Division of Nephrology and Renal Transplantation, Department of Medicine, Centro Hospitalar Lisboa Norte, EPE, Av. Prof. Egas Moniz, 1649-035 Lisboa, Portugal.

Introduction: The incidence of acute kidney injury (AKI) in coronavirus disease 2019 (COVID-19) patients ranges from 0.5% to 35% and has been associated with worse prognosis. The purpose of this study was to evaluate the incidence, severity, duration, risk factors and prognosis of AKI in hospitalized patients with COVID-19. Read More

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Acute kidney injury and chronic kidney disease after liver transplant: A retrospective observational study.

Nefrologia 2021 Jun 7. Epub 2021 Jun 7.

Division of Nephrology, Dialysis and Renal Transplantation, Maggiore Policlinico Hospital and Cà Granda IRCCS Foundation, Milano, Italy; University School of Medicine, Milano, Italy.

Background And Rationale: Chronic kidney disease remains an important risk factor for morbidity and mortality among LT recipients, but its exact incidence and risk factors are still unclear.

Material And Methods: We carried out a retrospective cohort study of consecutive adults who underwent liver transplant (January 2009-December 2018) and were followed (at least 6 months) at our institution. CKD was defined following the Kidney Disease: Improving Global Outcomes (KDIGO) 2012 Clinical Practice Guidelines. Read More

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A novel predictive model for poor in-hospital outcomes in patients with acute kidney injury after cardiac surgery.

J Thorac Cardiovasc Surg 2021 May 11. Epub 2021 May 11.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Objective: Patients with cardiac surgery-associated acute kidney injury are at risk of renal replacement therapy and in-hospital death. We aimed to develop and validate a novel predictive model for poor in-hospital outcomes among patients with cardiac surgery-associated acute kidney injury.

Methods: A total of 196 patients diagnosed with cardiac surgery-associated acute kidney injury were enrolled in this study as the training cohort, and 32 blood cytokines were measured. Read More

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European registry of type A aortic dissection (ERTAAD) - rationale, design and definition criteria.

J Cardiothorac Surg 2021 Jun 10;16(1):171. Epub 2021 Jun 10.

Leipzig Heart center, Leipzig, Germany.

Background: Acute Stanford type A aortic dissection (TAAD) is a life-threatening condition. Surgery is usually performed as a salvage procedure and is associated with significant postoperative early mortality and morbidity. Understanding the patient's conditions and treatment strategies which are associated with these adverse events is essential for an appropriate management of acute TAAD. Read More

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Comparison of renal histopathology and gene expression profiles between severe COVID-19 and bacterial sepsis in critically ill patients.

Crit Care 2021 06 10;25(1):202. Epub 2021 Jun 10.

Department of Critical Care, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

Background: The mechanisms driving acute kidney injury (AKI) in critically ill COVID-19 patients are unclear. We collected kidney biopsies from COVID-19 AKI patients within 30 min after death in order to examine the histopathology and perform mRNA expression analysis of genes associated with renal injury.

Methods: This study involved histopathology and mRNA analyses of postmortem kidney biopsies collected from patients with COVID-19 (n = 6) and bacterial sepsis (n = 27). Read More

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