78,398 results match your criteria Acute Renal Failure


Kidney Disease Awareness and Knowledge among Survivors ofAcute Kidney Injury.

Am J Nephrol 2019 Apr 17;49(6):449-459. Epub 2019 Apr 17.

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Vanderbilt Center for Kidney Diseases (VCKD) and Integrated Program for AKI Research (VIP-AKI), Nashville, Tennessee, USA.

Background: Acute kidney injury (AKI) survivors are at risk for chronic kidney disease, recurrent AKI, and cardiovascular disease. The transition from hospital to ambulatory care is an opportunity to reduce these sequelae by launching self-care plans through effective patient education. How well AKI survivors are informationally prepared to apply kidney-specific self-care is unknown. Read More

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https://www.karger.com/Article/FullText/499862
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http://dx.doi.org/10.1159/000499862DOI Listing
April 2019
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Gene Deletion of the Na-Glucose Cotransporter SGLT1Ameliorates Kidney Recovery in a Murine Model of Acute Kidney InjuryInduced by Ischemia-Reperfusion.

Am J Physiol Renal Physiol 2019 Apr 17. Epub 2019 Apr 17.

Departments of Medicine and Pharmacology, University of California San Diego and the Veterans Administration San Diego Healthcare System, United States.

The renal Na-glucose cotransporter SGLT1 mediates glucose reabsorption in the late proximal tubule, a hypoxia-sensitive tubular segment that enters the outer medulla. Gene-deletion in mice () was used to determine the role of the cotransporter in acute kidney injury (AKI) induced by ischemia-reperfusion (IR), including the initial injury and the subsequent recovery phase. On day 1 and 16 after IR, absolute and fractional urinary glucose excretion remained greater in versus wild-type littermates (WT), consistent with a sustained contribution of SGLT1 to tubular glucose reabsorption in WT. Read More

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http://dx.doi.org/10.1152/ajprenal.00111.2019DOI Listing

Adenosine kinase inhibition protects against cisplatin-induced nephrotoxicity.

Am J Physiol Renal Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department Of Nephrology, The First Affiliated Hospital of Nanjing Medical University.

Numerous studies have demonstrated that several mechanisms, including oxidative stress, DNA damage and inflammatory responses, are closely linked to cisplatin-induced nephrotoxicity. Adenosine, emerging as a key regulatory molecule, is mostly protective in the pathophysiology of inflammatory diseases. Previous study showed that some of the adenosine receptors led to renal protection against ischemia-reperfusion injury. Read More

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https://www.physiology.org/doi/10.1152/ajprenal.00385.2018
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http://dx.doi.org/10.1152/ajprenal.00385.2018DOI Listing
April 2019
1 Read

Apparent interference with extracorporeal membrane oxygenation by liposomal amphotericin B in a patient with disseminated blastomycosis receiving continuous renal replacement therapy.

Am J Health Syst Pharm 2019 Apr 17. Epub 2019 Apr 17.

Drake University College of Pharmacy and Health Sciences, Des Moines, IA.

Purpose: We describe the use of liposomal amphotericin B and amphotericin B deoxycholate in a critically ill patient with pulmonary blastomycosis receiving both venovenous extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT).

Summary: A 50-year-old African American man presented for dyspnea and cough and was noted to have blastomycosis on bronchoscopy. He developed respiratory failure and acute kidney injury, requiring mechanical ventilation, ECMO, and CRRT. Read More

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http://dx.doi.org/10.1093/ajhp/zxz054DOI Listing

Blood Pressure, One of the Most Important Factors Is Missing in the Analysis of the Association Between Intraoperative Oliguria and Acute Kidney Injury.

Authors:
Kohei Godai

Anesth Analg 2019 May;128(5):e81

Department of Anesthesiology and Critical Care Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan,

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http://dx.doi.org/10.1213/ANE.0000000000004081DOI Listing

Acute Kidney Injury, Chronic Kidney Disease, and Mortality: Understanding the Association.

Authors:
Melanie Meersch

Anesth Analg 2019 May;128(5):841-843

From the Department of Anesthesiology, Intensive Care and Pain Medicine, University of Münster, Münster, Germany.

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http://dx.doi.org/10.1213/ANE.0000000000004009DOI Listing

Protective effects of resveratrol on acute kidney injury in rats with sepsis.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2019 Apr 17. Epub 2019 Apr 17.

The Affiliated Hospital of Qingdao University, No.16 Jiangsu Road, Qingdao 266003, Shandong Province, China.

Aim: To evaluate the protective effects of resveratrol on acute kidney injury (AKI) in septic rats.

Methods: A septic rat model was established by cecal ligation and puncture (CLP). A total of 108 male Sprague Dawley rats were randomly divided into an observation group, a 6 h resveratrol intervention group and a 12 h resveratrol intervention group. Read More

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http://biomed.papers.upol.cz/doi/10.5507/bp.2019.006.html
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http://dx.doi.org/10.5507/bp.2019.006DOI Listing
April 2019
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Evaluation of Renal Pathophysiological Processes Induced by an Iodinated Contrast Agent in a Diabetic Rabbit Model Using Intravoxel Incoherent Motion and Blood Oxygenation Level-Dependent Magnetic Resonance Imaging.

Korean J Radiol 2019 May;20(5):830-843

Department of Radiology, First Hospital of China Medical University, Shenyang, China.

Objective: To examine the potential of intravoxel incoherent motion (IVIM) and blood oxygen level-dependent (BOLD) magnetic resonance imaging for detecting renal changes after iodinated contrast-induced acute kidney injury (CI-AKI) development in a diabetic rabbit model.

Materials And Methods: Sixty-two rabbits were randomized into 2 groups: diabetic rabbits with the contrast agent (DCA) and healthy rabbits with the contrast agent (NCA). In each group, 6 rabbits underwent IVIM and BOLD imaging at 1 hour, 1 day, 2 days, 3 days, and 4 days after an iohexol injection while 5 rabbits were selected to undergo blood and histological examinations at these specific time points. Read More

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http://dx.doi.org/10.3348/kjr.2018.0757DOI Listing

Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation.

J Cell Mol Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Nephrology, The Key Laboratory of Kidney Disease and Blood Purification of Hunan Province, Second Xiangya Hospital at Central South University, Changsha, China.

Renal interstitial fibrosis is a common pathological feature in progressive kidney diseases currently lacking effective treatment. Nicotinamide (NAM), a member of water-soluble vitamin B family, was recently suggested to have a therapeutic potential for acute kidney injury (AKI) in mice and humans. The effect of NAM on chronic kidney pathologies, including renal fibrosis, is unknown. Read More

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http://doi.wiley.com/10.1111/jcmm.14285
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http://dx.doi.org/10.1111/jcmm.14285DOI Listing
April 2019
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Augmenter of liver regeneration protects the kidney from ischaemia-reperfusion injury in ferroptosis.

J Cell Mol Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Nephrology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China.

Acute kidney injury (AKI) is a common and severe clinical condition with high morbidity and mortality. Ischaemia-reperfusion (I/R) injury remains the major cause of AKI in the clinic. Ferroptosis is a recently discovered form of programmed cell death (PCD) that is characterized by iron-dependent accumulation of reactive oxygen species (ROS). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14302
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http://dx.doi.org/10.1111/jcmm.14302DOI Listing
April 2019
2 Reads

Comparison of creatinine and cystatin C for estimation of glomerular filtration rate in pediatric patients after Fontan operation.

Congenit Heart Dis 2019 Apr 16. Epub 2019 Apr 16.

Section of Pediatric Cardiology, Department of Pediatrics, University of Colorado, Children's Hospital Colorado, Aurora, Colorado.

Background: There are several limitations when using creatinine to estimate glomerular filtration rate, especially in children with chronic medical conditions who are at high risk of kidney dysfunction. Cystatin C has been the recent focus of research as a replacement biomarker for creatinine. Our objective was to compare the 2 biomarkers in pediatric single-ventricle heart disease patients who have undergone the Fontan operation. Read More

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http://dx.doi.org/10.1111/chd.12776DOI Listing

Clinical safety and efficacy of tolvaptan for acute phase therapy in patients with low-flow and normal-flow severe aortic stenosis.

Heart Vessels 2019 Apr 16. Epub 2019 Apr 16.

Division of Cardiology, Department of Internal Medicine, Teikyo University, 2-11-1 Kaga, Tokyo, 173-8606, Japan.

Conventional diuretic therapy for low-flow (LF) severe aortic stenosis (SAS) often has an inadequate effect or causes hemodynamic instability. Tolvaptan is used for acute heart failure in addition to conventional diuretics, and it does not cause intravascular dehydration. This study aimed to retrospectively investigate the safety and efficacy of tolvaptan in the acute phase in 56 consecutive patients with SAS and compared LF-SAS with normal-flow (NF) SAS. Read More

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http://link.springer.com/10.1007/s00380-019-01411-3
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http://dx.doi.org/10.1007/s00380-019-01411-3DOI Listing
April 2019
4 Reads

Estimating the Change in Renal Function During the First Year of Therapy in ANCA-Associated Vasculitis.

Kidney Int Rep 2019 Apr 13;4(4):594-602. Epub 2019 Feb 13.

Nephrology Division, Hôpital du Sacré-Coeur de Montréal, Québec, Canada.

Introduction: Studies in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) consistently show that the months following diagnosis have the greatest impact on the long-term renal function. Yet, it remains uncertain how much early gain should be expected with treatment. We sought to determine the factors associated with the change in glomerular filtration rate (GFR) throughout the first year. Read More

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http://dx.doi.org/10.1016/j.ekir.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451086PMC

Predicting Renal Recovery After Dialysis-Requiring Acute Kidney Injury.

Kidney Int Rep 2019 Apr 28;4(4):571-581. Epub 2019 Jan 28.

Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.

Introduction: After dialysis-requiring acute kidney injury (AKI-D), recovery of sufficient kidney function to discontinue dialysis is an important clinical and patient-oriented outcome. Predicting the probability of recovery in individual patients is a common dilemma.

Methods: This cohort study examined all adult members of Kaiser Permanente Northern California who experienced AKI-D between January 2009 and September 2015 and had predicted inpatient mortality of <20%. Read More

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http://dx.doi.org/10.1016/j.ekir.2019.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451155PMC

Predicting Outcomes in Acute Kidney Injury Survivors: Searching for the Crystal Ball.

Kidney Int Rep 2019 Apr 28;4(4):520-521. Epub 2019 Feb 28.

Division of Nephrology, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ekir.2019.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451151PMC

Multiple Faces of Chronic Lymphocytic Leukaemia: A Patient with Renal, Cardiac, and Skeletal Complications.

Case Rep Nephrol 2019 12;2019:5390235. Epub 2019 Mar 12.

Department of Renal Medicine, Norfolk and Norwich University Hospital, Norwich, UK.

We describe a patient who had chronic lymphocytic leukaemia (CLL) Binet stage A at presentation with further evidence of disease at multiple sites but who initially required no treatment. However, several years later, her peripheral blood lymphocyte count started to increase, and soon after that she suffered an acute myocardial infarct (in the absence of coronary atheroma) together with proteinuric renal failure due to membranoproliferative glomerulonephritis. Her renal function improved markedly following anti-CLL chemotherapy. Read More

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http://dx.doi.org/10.1155/2019/5390235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434293PMC

Role of Parathyroid Hormone Assay and Bedside Ultrasound in the Emergency Department in Differentiating Acute Kidney Injury from Chronic Kidney Disease: A Systematic Review.

Emerg Med Int 2019 12;2019:2102390. Epub 2019 Mar 12.

Department of Renal Medicine, Changi General Hospital, Singapore, Singapore.

Introduction: It is not uncommon for patients without preceding history of kidney disease to present to the Emergency department with renal failure. The absence of prior medical records or renal imaging presents a diagnostic challenge. Elevated parathyroid hormone levels or echogenic contracted kidneys on ultrasound are known to point to a diagnosis of chronic kidney disease. Read More

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http://dx.doi.org/10.1155/2019/2102390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434274PMC

Kidney Injury Molecule 1 (KIM-1) as an Early Predictor for Acute Kidney Injury in Post-Cardiopulmonary Bypass (CPB) in Open Heart Surgery Patients.

Int J Nephrol 2019 12;2019:6265307. Epub 2019 Mar 12.

Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Mansoura University, Egypt.

Introduction: Postoperative acute kidney injury is associated with a higher mortality, a more complicated hospital course with longer hospital stay. Urinary kidney injury molecule 1 may play an important role as an early predictor of acute kidney injury post-cardiopulmonary in open heart surgery.

Methods: We evaluated 45 patients who underwent open heart surgery from January 2016 to June 2016. Read More

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http://dx.doi.org/10.1155/2019/6265307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434264PMC

Characteristics of Nonpulmonary Organ Dysfunction at Onset of ARDS Based on the Berlin Definition.

Respir Care 2019 Apr 16. Epub 2019 Apr 16.

Department of Pulmonary and Critical Care Medicine, University of California, San Francisco at San Francisco General Hospital, San Francisco, California.

Background: The Berlin definition of ARDS does not account for nonpulmonary organ failure, which is a major determinant of outcome. We examined whether an increasing severity of hypoxemia across the Berlin definition classifications also corresponded with evidence of multiple organ dysfunction on the day of ARDS onset. We also examined the representation of major etiologies for ARDS across the Berlin definition classifications. Read More

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http://dx.doi.org/10.4187/respcare.06165DOI Listing

The prominent impairment of liver/intestinal cytochrome P450 and intestinal drug transporters in sepsis-induced acute kidney injury over acute and chronic renal ischemia, a mouse model comparison.

Ren Fail 2019 Nov;41(1):314-325

c Center of Excellence in Immunology and Immune-mediated Diseases , Chulalongkorn University , Bangkok , Thailand.

Drug dosing adjustment in sepsis-induced acute kidney injury (sepsis-AKI) is currently adjusted based on renal function. Sepsis is a multiorgan injury, and thus, drug metabolism in sepsis-AKI might be interfered by non-renal factors such as changes in functions of drug-metabolizing enzymes in the liver and functions of intestinal drug transporters. We compared the defect on mouse CYP3A11 (human CYP3A4 representative) in liver and intestine along with several intestinal drug transporters (MDR1a, MRP2, and OATP3) in three mouse models; chronic ischemic reperfusion injury (Chr I/R; 4-week), acute ischemic reperfusion injury (Acute I/R; 24-h), and cecal ligation and puncture (CLP; 24-h) as representative of sepsis-AKI. Read More

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http://dx.doi.org/10.1080/0886022X.2019.1602054DOI Listing
November 2019

Predisposing factors for hypoglycaemia in the emergency department.

J Int Med Res 2019 Apr 16:300060519842037. Epub 2019 Apr 16.

1 Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan.

Objective: Hypoglycaemia is a common complication of diabetes mellitus. Previous studies suggest that hypoglycaemic episodes may occur with other comorbidities, influencing the outcome of recovery. Recognising the predisposing factors for hypoglycaemic episodes in the emergency department is important. Read More

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http://dx.doi.org/10.1177/0300060519842037DOI Listing

The Impact of Obesity in Patients Undergoing Robotic Partial Nephrectomy.

J Endourol 2019 Apr 16. Epub 2019 Apr 16.

Icahn School of Medicine at Mount Sinai, Urology, New York, New York, United States ;

Introduction/background: As the prevalence of obesity increases worldwide, an increasing proportion of surgical candidates have an elevated BMI, with associated metabolic syndrome. Yet there exists limited evidence regarding the effect of elevated BMI on surgical outcomes in robotic surgeries. We examined whether obese patients had worse perioperative outcomes and postoperative renal function following robotic partial nephrectomies (RPNs). Read More

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http://dx.doi.org/10.1089/end.2019.0018DOI Listing

The Ameliorating Effect of Plasma Protein from on Cyclophosphamide-Induced Acute Kidney Injury in Mice.

Mar Drugs 2019 Apr 15;17(4). Epub 2019 Apr 15.

Department of Applied Chemistry, College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China.

In the study, the protective effect of plasma protein from (PPTT) on acute kidney injury (AKI) and the related molecular mechanisms were first investigated by Western blotting analyses, TdT-mediated dUTP Nick-End Labeling (TUNEL) assay, and immunohistochemistry. It was found that PPTT had an obviously inhibitory effect on Reactive oxygen species (ROS) in cyclophosphamide (CTX)-exposed mice. Furthermore, results demonstrated that the renal cell death mode is due to inducing apoptosis and autophagy inhibited by dose-dependent PPTT in mice treated with CTX by decreasing the protein expression of bax, beclin-1, and LC3 and increasing the expression of bcl-2. Read More

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http://dx.doi.org/10.3390/md17040227DOI Listing

Effect of Furosemide under Hyperchloremic Acidosis on Intraoperative Oliguria and Acute Kidney Injury in Patients with Normal Renal Function.

Nephron 2019 Apr 16:1-8. Epub 2019 Apr 16.

Department of Anesthesiology, Hamamatsu Rosai Hospital, Japan Organization of Occupational Health and Safety, Hamamatsu, Japan.

Background: Renal function tends to deteriorate in a hyperchloremic acidifying environment, which is reflected by a decrease in the difference between sodium and chloride.

Objectives: To examine the effect of furosemide administered under hyperchloremic acidosis on intraoperative oliguria and acute kidney injury in patients with preoperatively normal renal function.

Methods: In patients undergoing abdominal or orthopedic surgeries (April 2010-November 2018), we retrospectively identified patients who preoperatively had a normal renal function but experienced intraoperative oliguria under hyperchloremic acidosis (a sodium-chloride difference < 30 mEq/L) without dehydration. Read More

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http://dx.doi.org/10.1159/000499938DOI Listing

The Role of Uric Acid in Acute Kidney Injury.

Nephron 2019 Apr 16:1-9. Epub 2019 Apr 16.

Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA.

Studies have demonstrated the presence of a strong association between serum uric acid (SUA) and acute kidney injury (AKI) consistently across several disease models. Exposure to SUA at different time periods and concentrations has reliably resulted in AKI whether assessed by conventional or novel biomarkers or by kinetic estimated glomerular filtration rate (KeGFR) engineered for non-steady dynamic states. In experimental models, moderate hyperuricemia was associated with an absence of intrarenal crystals, manifestation of tubular injury, macrophage infiltration, and increased expression of inflammatory mediators that were attenuated with uric acid lowering therapy with rasburicase, a recombinant urate oxidase. Read More

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http://dx.doi.org/10.1159/000499939DOI Listing

Kidney recovery in patients discharged to an acute rehabilitation facility with acute kidney injury requiring hemodialysis
.

Clin Nephrol 2019 Apr 16. Epub 2019 Apr 16.

Background: Patients with acute kidney injury requiring renal replacement therapy (AKI-RRT) are at risk of adverse outcomes. Little is known about the incidence of AKI-RRT recovery following hospital discharge. We examine AKI-RRT recovery in hospital survivors discharged to a long-term acute care hospital (LTACH) with need of hemodialysis (HD) for AKI. Read More

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http://dx.doi.org/10.5414/CN109743DOI Listing

[Effect of emodin on gut microbiota of rats with acute kidney failure].

Zhongguo Zhong Yao Za Zhi 2019 Feb;44(4):758-764

College of Pharmaceutical Science,Zhejiang Chinese Medical University Hangzhou 311402,China.

The aim of this paper was to investigate the effect of emodin on gut microbiota in acute kidney injury rats( AKI). Rats were randomly divided into several groups: normal group,model group,low-dose of emodin group( 10 mg·kg~(-1)),medium-dose of emodin group( 25 mg·kg~(-1)),high-dose of emodin group( 50 mg·kg~(-1)) and control group( 5 mg·kg~(-1) of benazepril hydrochloride).The AKI model rats were established by intraperitoneal injection of small dose of gentamicin sulfate for 7 days. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20181105.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181105.002DOI Listing
February 2019
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[Study on acute kidney injury model induced by renal ischemia-reperfusion in rats].

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(5):996-1003

Jiangxi University of Traditional Chinese Medicine Nanchang 330006,China State Key Laboratory of Innovative Drugs and Efficient Energy-saving Pharmaceutical Equipment,Jiangxi University of Traditional Chinese Medicine Nanchang 330006,China.

In this study,in-depth systematic evaluation of rat of acute kidney injury(AKI) caused by renal arteriovenous ligation was conducted to better master and apply this model for drug research. Male SD rats of 2-3 months old were employed in this study.The left kidney was removed,and the right kidney received ligation for 40 min and reperfusion for 24 h. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20181218.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181218.001DOI Listing
March 2019
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Incidence of acute kidney injury among pediatric hematology/oncology patients receiving vancomycin in combination with piperacillin/tazobactam or cefepime.

Pediatr Blood Cancer 2019 Apr 16:e27750. Epub 2019 Apr 16.

Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee.

There is mounting evidence that combination of antibiotic therapy with vancomycin and piperacillin/tazobactam (pip/tazo) is associated with acute kidney injury (AKI). To determine whether vancomycin plus pip/tazo is associated with higher rates of AKI compared to vancomycin plus cefepime among pediatric hematology/oncology (heme/onc) patients, we examined 121 heme/onc patients receiving at least two consecutive days of therapy with vancomycin and either pip/tazo or cefepime. Rate of AKI was higher in the pip/tazo than the cefepime group (4/27 [14. Read More

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http://dx.doi.org/10.1002/pbc.27750DOI Listing

New mineralocorticoid receptor antagonists: update on their use in chronic kidney disease and heart failure.

J Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Department of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, S. Orsola Hospital, University of Bologna, Via Massarenti 9, 40100, Bologna, Italy.

Aldosterone is a mineralocorticoid hormone with a well-known effect on the renal tubule leading to water retention and potassium reabsorption. Other major effects of the hormone include the induction of proinflammatory activity that leads to progressive fibrotic damage of the target organs, heart and kidney. Blocking the aldosterone receptor therefore represents an important pharmacological strategy to avoid the clinical conditions deriving from heart failure (CHF) and chronic kidney disease (CKD). Read More

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http://dx.doi.org/10.1007/s40620-019-00600-7DOI Listing

Impact of Preoperative Anemia on Postoperative Kidney Function Following Laparoscopic Bariatric Surgery.

Obes Surg 2019 Apr 13. Epub 2019 Apr 13.

Weight Loss and Health Management Center, E-Da Dachang Hospital, No. 305, Dachang 1st Rd., Sanmin Dist., Kaohsiung City, 807, Taiwan.

Background: Preoperative anemia is a risk factor for acute kidney failure after high-risk surgeries. We assessed the impact of preoperative anemia on kidney function in an obese Asian population after laparoscopic bariatric surgery.

Methods: Patient characteristics, comorbidities, type of surgery, perioperative profiles, eGFR, and micronutrition were retrospectively reviewed in 341 patients with obesity undergoing bariatric surgery. Read More

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http://dx.doi.org/10.1007/s11695-019-03869-6DOI Listing

Acute kidney injury in patients with HELLP syndrome.

Int Urol Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuifuyuan 1, Wangfujing, Beijing, 100730, China.

Purpose: To evaluate the risk factors and renal prognosis of acute kidney injury (AKI) in patients with hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome.

Methods: Women with HELLP syndrome over a 15-year period at Peking Union Medical College Hospital, China, were retrospectively studied.

Results: A total of 108 patients with HELLP syndrome were included. Read More

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http://link.springer.com/10.1007/s11255-019-02111-7
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http://dx.doi.org/10.1007/s11255-019-02111-7DOI Listing
April 2019
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Renal histopathology of prolonged acute kidney injury in HELLP syndrome: a case series and literature review.

Int Urol Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuifuyuan 1, Wangfujing, Beijing, 100730, China.

Purpose: Acute kidney injury (AKI) is a severe complication of hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. However, renal pathological investigation of AKI in this syndrome has rarely been reported. We aimed to evaluate the renal pathological changes of persistent AKI and its relationship with renal outcomes in HELLP syndrome. Read More

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http://dx.doi.org/10.1007/s11255-019-02135-zDOI Listing

Low incidence of nephrotoxicity following intravenous administration of iodinated contrast media: a prospective study.

Eur Radiol 2019 Apr 11. Epub 2019 Apr 11.

Department of Biomedical Sciences and Public Health, School of Medicine, University "Politecnica delle Marche", Via Tronto 10/A, 60126, Ancona, Italy.

Objectives: To estimate the incidence of contrast-induced acute kidney injury (CI-AKI) after intravenous (iv) iodinated contrast material (ICM) exposure.

Methods: This prospective cohort study included all consecutive patients who underwent radiological investigations using low-osmolar iopamidol 370 mg/ml in a regional hospital over a period of 36 months, without any exclusion criteria. The estimated glomerular filtration rate (eGFR) was evaluated using the MRDR equation before (2-10 days) and after (24-36 h) radiological investigations. Read More

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http://dx.doi.org/10.1007/s00330-019-06147-2DOI Listing

Hemolytic uremic syndrome in a developing country: Consensus guidelines.

Pediatr Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Immunology, Hopital Europeen Georges Pompidou, INSERM UMRS 1138, Paris Descartes University, Paris, France.

Background: Hemolytic uremic syndrome (HUS) is a leading cause of acute kidney injury in children. Although international guidelines emphasize comprehensive evaluation and treatment with eculizumab, access to diagnostic and therapeutic facilities is limited in most developing countries. The burden of Shiga toxin-associated HUS in India is unclear; school-going children show high prevalence of anti-factor H (FH) antibodies. Read More

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http://link.springer.com/10.1007/s00467-019-04233-7
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http://dx.doi.org/10.1007/s00467-019-04233-7DOI Listing
April 2019
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Re: "Late Presentation of a 9mm Bullet in the Ureteropelvic Junction Causing Acute Renal Failure in a Solitary Functioning Left Kidney" by Jhaveri and D'Angelo ( 2018;4:173-175).

J Endourol Case Rep 2019 18;5(1):28-29. Epub 2019 Mar 18.

Department of Reconstructive Urology, St. Helens and Knowsley Hospital NHS Trust, Whiston Hospital, Liverpool, United Kingdom.

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http://dx.doi.org/10.1089/cren.2018.0114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461057PMC

Baseline urinary KIM-1 concentration in detecting acute kidney injury should be interpreted with patient pre-existing nephropathy.

Pract Lab Med 2019 May 7;15:e00118. Epub 2019 Mar 7.

Discipline of Laboratory Medicine, Eastern Health Authority, 300 Prince Philip Dr, St. John's, NL, Canada.

Objectives: To determine whether pre-existing nephropathy impacts urinary KIM-1 levels, urinary KIM-1 were measured in patients with normal kidney filtration function but either with or without proteinuria. The reference intervals of urinary KIM-1 in adults with normal kidney filtration function but without urine proteinuria were established.

Design And Methods: 188 urine samples were obtained from adults with normal kidney filtration. Read More

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http://dx.doi.org/10.1016/j.plabm.2019.e00118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447747PMC

Acute Tubular Injury is Associated With Severe Traumatic Brain Injury: in Vitro Study on Human Tubular Epithelial Cells.

Sci Rep 2019 Apr 15;9(1):6090. Epub 2019 Apr 15.

Department of Anesthesia and Intensive Care, University of Turin, Città della Salute e della Scienza - Molinette University Hospital, Turin, Italy.

Acute kidney injury following traumatic brain injury is associated with poor outcome. We investigated in vitro the effects of plasma of brain injured patients with acute tubular kidney injury on kidney tubular epithelial cell function. we performed a prospective observational clinical study in ICU in a trauma centre of the University hospital in Italy including twenty-three ICU patients with traumatic brain injury consecutively enrolled. Read More

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http://dx.doi.org/10.1038/s41598-019-42147-4DOI Listing

A Rare Case of Acute Kidney Injury: McKittrick Wheelock Syndrome.

Iran J Kidney Dis 2019 Mar;13(2):132-133

University of Health Sciences, Konya Research and Training Hospital, Nephrology Department, Konya, Turkey.

McKittrick-Wheelock syndrome is a rare complication of rectosigmoid villous adenoma leading to secretory diarrhea, prerenal acute kidney injury and severe fluid and electrolyte imbalances. There are about 50 cases reported in literature. We represent a case of 71 year-old patient with persistant chronic diarrhea, prerenal azotemia, severe hypokalemia, and hyponatremia. Read More

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March 2019
1 Read

Acute Kidney Injury Following Usage of Formaldehyde-Free Hair Straightening Products.

Iran J Kidney Dis 2019 Mar;13(2):129-131

Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Egypt.

Acute kidney injury is manifested by sudden deterioration of kidney functions, with or without reduction of urine output. The spectrum of injury ranges from mild to severe, sometimes requires renal replacement therapy. The initial workup includes a patient history to identify the use of nephrotoxic medications or systemic illnesses that may cause poor renal perfusion or directly impair renal function. Read More

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March 2019
3 Reads

Pharmacological inhibition of TRPV4 channels protects against ischemia-reperfusion-induced renal insufficiency in neonatal pigs.

Clin Sci (Lond) 2019 Apr 15. Epub 2019 Apr 15.

Physiology, University of Tennessee Health Science Center, 956 Court Ave, Suite C211 Coleman Bldg, Memphis, Tennessee, 38163, United States

Renal vasoconstriction, an early manifestation of ischemic acute kidney injury (AKI) results in renal hypoperfusion and a rapid decline in kidney function. The pathophysiological mechanisms that underlie ischemia-reperfusion (IR)-induced renal insufficiency are poorly understood, but possibilities include alterations in ion channel-dependent renal vasoregulation. In this study, we show that pharmacological activation of TRPV4 channels constricted preglomerular microvessels and elicited renal hypoperfusion in neonatal pigs. Read More

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http://dx.doi.org/10.1042/CS20180815DOI Listing

Mechanical, inflammatory, and embolic complications of myocardial infarction: An emergency medicine review.

Am J Emerg Med 2019 Apr 8. Epub 2019 Apr 8.

Brooke Army Medical Center, Department of Emergency Medicine, 3841 Roger Brooke Dr, Fort Sam Houston, TX 78234, United States. Electronic address:

Introduction: Despite the declining incidence of coronary heart disease (CHD) in the United States, acute myocardial infarction (AMI) remains an important clinical entity, with many patients requiring emergency department (ED) management for mechanical, inflammatory, and embolic complications.

Objective: This narrative review provides an evidence-based summary of the current data for the emergency medicine evaluation and management of post myocardial infarction mechanical, inflammatory, and embolic complications.

Discussion: While 30-day mortality rate after AMI has decreased in the past two decades, it remains significantly elevated at 7. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.04.003DOI Listing

Clinicopathological spectrum of renal parenchymal involvement in B-cell lymphoproliferative disorders.

Kidney Int 2019 Mar 15. Epub 2019 Mar 15.

Department of Nephrology and Renal Transplantation, Centre Hospitalier Universitaire, Université de Poitiers, Poitiers, France; CNRS UMR 7276, INSERM UMR 1262, Université de Limoges, Limoges, France; INSERM CIC 1402, Centre Hospitalier Universitaire, Poitiers, France.

The clinicopathological characteristics of kidney infiltration in B-cell lymphoproliferative disorders remain poorly described. We retrospectively studied 52 adults with biopsy-proven malignant B-cell kidney infiltration, including Waldenström's macroglobulinemia (n=21), chronic lymphocytic leukemia (n=11), diffuse large B-cell lymphoma (DLBCL) (n=8), other lymphoma (n=11), and multiple myeloma (n=1). Kidney disease varied according to the underlying lymphoproliferative disorder. Read More

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http://dx.doi.org/10.1016/j.kint.2019.01.027DOI Listing

Racial/ethnic disparities in patients undergoing transcatheter aortic valve replacement: Insights from the healthcare cost and utilization project's national inpatient sample.

Cardiovasc Revasc Med 2019 Apr 9. Epub 2019 Apr 9.

Division of Cardiovascular and Thoracic Anesthesiology, Mayo Clinic, Phoenix, AZ, USA.

Purpose: To identify racial/ethnic disparities in utilization rates, in-hospital outcomes and health care resource use among Non-Hispanic Whites (NHW), African Americans (AA) and Hispanics undergoing transcatheter aortic valve replacement (TAVR) in the United States (US).

Methods And Results: The National Inpatient Sample database was queried for patients ≥18 years of age who underwent TAVR from 2012 to 2014. The primary outcome was all-cause in hospital mortality. Read More

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http://dx.doi.org/10.1016/j.carrev.2019.04.005DOI Listing

Predictors of short-term successful discontinuation of continuous renal replacement therapy: results from a prospective multicentre study.

BMC Nephrol 2019 Apr 15;20(1):129. Epub 2019 Apr 15.

Department of Intensive Care, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Background: Prediction of successful discontinuation of continuous renal replacement therapy (CRRT) might reduce complications of over- and under-treatment. The aim of this study was to identify renal and non-renal predictors of short-term successful discontinuation of CRRT in patients in whom CRRT was stopped because renal recovery was expected and who were still in the Intensive Care Unit (ICU) at day 2 after stop CRRT.

Methods: Prospective multicentre observational study in 92 patients alive after discontinuation of CRRT for acute kidney injury (AKI), still in the ICU and free from renal replacement therapy (RRT) at day 2 after discontinuation. Read More

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http://dx.doi.org/10.1186/s12882-019-1327-9DOI Listing

Neutrophil gelatinase-associated lipocalin as a marker of postoperative acute kidney injury following cardiac surgery in patients with pre-operative kidney impairment.

Cardiovasc Hematol Disord Drug Targets 2019 Apr 15. Epub 2019 Apr 15.

Liverpool Heart & Chest Hospital NHS Foundation Trust, Thomas Drive, Liverpool L14 3PE. United Kingdom.

Introduction: Acute kidney injury (AKI) is a serious complication of cardiac surgery. The current 'gold standard' for determining AKI is change in serum creatinine and urine output, however, this change occurs relatively late after actual injury occurs. Identification of new biomarkers that detect early AKI is required. Read More

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http://www.eurekaselect.com/171613/article
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http://dx.doi.org/10.2174/1871529X19666190415115106DOI Listing
April 2019
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Hypertension In Chronic Kidney Disease: Novel Insights.

Curr Hypertens Rev 2019 Apr 15. Epub 2019 Apr 15.

Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki. Greece.

Management of arterial hypertension in patients with chronic kidney disease (CKD) remains a major challenge due to its high prevalence and its associations with cardiovascular disease (CVD) and CKD progression. Several clinical trials and meta-analyses have demonstrated that aggressive treatment of hypertension in patients with and without CKD lowers the risk of CVD and all-cause mortality, nevertheless the effects of blood pressure (BP) lowering in terms of renal protection or harm remain controversial. Both home and ambulatory BP estimation have shown that patients with CKD display abnormal BP patterns outside of the office and further investigation is required, so as to compare the association of ambulatory versus office BP measurements with hard outcomes and adjust treatment strategies accordingly. Read More

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http://dx.doi.org/10.2174/1573402115666190415153554DOI Listing
April 2019
1 Read

Development of renal function during staged balloon pulmonary angioplasty for inoperable chronic thromboembolic pulmonary hypertension.

Scand J Clin Lab Invest 2019 Apr 15:1-8. Epub 2019 Apr 15.

a Department of Cardiology , Kerckhoff Heart and Thorax Center , Bad Nauheim , Germany.

Balloon pulmonary angioplasty (BPA), for chronic thromboembolic pulmonary hypertension, improves pulmonary and systemic hemodynamics. The kidney might benefit from this effect. However, staged BPA therapy comes along with repetitive administration of contrast agent. Read More

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http://dx.doi.org/10.1080/00365513.2019.1601765DOI Listing

Continuous Renal Replacement Therapy with High Flow Rate Can Effectively, Safely, and Quickly Reduce Plasma Ammonia and Leucine Levels in Children.

Children (Basel) 2019 Apr 4;6(4). Epub 2019 Apr 4.

Department of Pediatric Intensive Care Unit, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Fatih, Istanbul 34098, Turkey.

: Peritoneal dialysis and continuous renal replacement therapy (CRRT) are the most frequently used treatment modalities for acute kidney injury. CRRT is currently being used for the treatment of several non-renal indications, such as congenital metabolic diseases. CRRT can efficiently remove toxic metabolites and reverse the neurological symptoms quickly. Read More

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http://dx.doi.org/10.3390/children6040053DOI Listing