22,836 results match your criteria Acute Poliomyelitis


Highly Crosslinked Polyethylene Tibial Post Fracture in the Unafflicted Limb of a Patient with Unilateral Lower Limb Poliomyelitis: A Case Report.

Authors:
W C Lee Lhj Wee

Malays Orthop J 2019 Mar;13(1):42-44

Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore.

We present a unique case of tibial post fracture of a posterior-stabilised total knee arthroplasty (PS-TKA) using highly crosslinked polyethylene (HXLPE) in the unafflicted limb of a patient who had poliomyelitis. The tibial post is an upright structure perpendicular to the PE insert articular surface which articulates with the cam of the femoral component to prevent excessive posterior translation of the tibia. We explore the choice of PS polyethylene (PE) inserts in patients with neuromuscular disorders (NMD). Read More

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http://www.morthoj.org/2019/v13n1/tibial-post-fracture.pdf
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http://dx.doi.org/10.5704/MOJ.1903.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459040PMC
March 2019
2 Reads

Vaccine hesitancy: An overview on parents' opinions about vaccination and possible reasons of vaccine refusal.

J Public Health Res 2019 Mar 11;8(1):1436. Epub 2019 Mar 11.

Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy.

Vaccine hesitancy has increased worldwide with a subsequent decreasing of vaccination rates and outbreaks of vaccine-preventable diseases (i.e. measles, poliomyelitis and pertussis) in several developed countries, including Italy. Read More

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http://dx.doi.org/10.4081/jphr.2019.1436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444379PMC
March 2019
1 Read

Near full-length HIV-1 subtype B sequences from the early South African epidemic, detecting a BD unique recombinant form (URF) from a sample in 1985.

Sci Rep 2019 Apr 17;9(1):6227. Epub 2019 Apr 17.

Division of Medical Virology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Cape Town, 8000, South Africa.

HIV-1 subtype C is the most prevalent subtype in South Africa. Although subtype B was previously detected in South Africa, there is limited sequence information available. We characterized near full-length HIV-1 subtype B sequences from samples collected at the start of the South African HIV-1 epidemic, in the 1980s. Read More

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http://www.nature.com/articles/s41598-019-42417-1
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http://dx.doi.org/10.1038/s41598-019-42417-1DOI Listing
April 2019
2 Reads

Monoclonal antibodies point to Achilles' heel in picornavirus capsid.

Authors:
Mihnea Bostina

PLoS Biol 2019 Apr 17;17(4):e3000232. Epub 2019 Apr 17.

Department of Microbiology and Immunology and Otago Micro and Nano Imaging, University of Otago, Dunedin, New Zealand.

Picornaviruses are small, icosahedral, nonenveloped, positive-sense, single-stranded RNA viruses that form one of the largest and most important viral families. Numerous Picornaviridae members pose serious health or agricultural threats, causing diseases such as poliomyelitis, hepatitis A, or foot-and-mouth disease. The antigenic characterization of picornavirus capsids plays an important role in understanding the mechanism of viral neutralization and the conformational changes associated with genome release, and it can point to regions which can be targeted by small-molecule compounds to be developed as antiviral inhibitors. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000232DOI Listing
April 2019
2 Reads

Today's vaccination policies in Italy: The National Plan for Vaccine Prevention 2017-2019 and the Law 119/2017 on the mandatory vaccinations.

Ann Ig 2019 Mar-Apr;31(2 Supple 1):54-64

Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, Italy.

The National Plan for Vaccine Prevention 2017-2019 has expanded the vaccination offer including new vaccines, enlarging the target population and introducing for the first time in Italy a life-course approach to vaccination. A "lifetime immunization schedule" is aimed to reduce the burden and the related costs of vaccine-preventable diseases through effective vaccination programs. However, to counteract the national steady downward trend in the uptake of vaccinations that caused a drop of the vaccination coverage below the 95% threshold to allow herd immunity, it was decided to make 10 vaccinations mandatory by the law 119/2017. Read More

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http://dx.doi.org/10.7416/ai.2019.2277DOI Listing
April 2019
1 Read

Acute flaccid paralysis in North East Delta, Egypt: A retrospective analysis of prospectively collected surveillance data.

J Infect Public Health 2019 Apr 13. Epub 2019 Apr 13.

Ministry of Health, Egypt. Electronic address:

Background: Effective acute flaccid paralysis (AFP) surveillance is crucial in countries approaching the final phase of polio eradication. Thus this study was conducted to highlight the epidemiological pattern of AFP as a surveillance tool for polio in Egypt.

Methods: A record-based descriptive study was conducted to include all AFP cases (599) reported in the last 9 years starting from January 2009 to December 2017 in Dakahlia, North East of Delta, Egypt. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18760341193012
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http://dx.doi.org/10.1016/j.jiph.2019.03.016DOI Listing
April 2019
2 Reads

Incidence, Risk Factors and Outcomes Among Children With Acute Flaccid Myelitis: A Population-based Cohort Study in a California Health Network Between 2011 and 2016.

Pediatr Infect Dis J 2019 Apr 10. Epub 2019 Apr 10.

Department of Pediatric Infectious Diseases, Kaiser Permanente Oakland Medical Center, Oakland, California.

Background: Acute flaccid myelitis (AFM) is defined as an acute onset of limb weakness with longitudinal spinal gray matter lesions. Reporting bias and misdiagnosis confound epidemiologic studies of AFM. We mitigated these confounders by using a large data set to assess AFM incidence, risk factors and outcomes in a fixed population. Read More

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http://dx.doi.org/10.1097/INF.0000000000002276DOI Listing
April 2019
1 Read

Immunogenicity and Safety of a Sabin Strain-Based Inactivated Polio Vaccine: A Phase 3 Clinical Trial.

J Infect Dis 2019 Apr 8. Epub 2019 Apr 8.

Office of the General Manager, Sinovac Biotech, Beijing.

Background: The Sabin strain-based inactivated polio vaccine (sIPV) plays a vital role in eradicating poliomyelitis in developing countries.

Methods: The study was designed as a randomized, controlled, double-blinded, noninferiority trial. A total of 1200 healthy infants aged 60-90 days were enrolled and randomly assigned to receive 3 doses of either sIPV (the experimental arm) or IPV (the control arm) at days 0, 30, and 60. Read More

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http://dx.doi.org/10.1093/infdis/jiy736DOI Listing
April 2019
1 Read

Surveillance to Track Progress Toward Polio Eradication - Worldwide, 2017-2018.

MMWR Morb Mortal Wkly Rep 2019 Apr 5;68(13):312-318. Epub 2019 Apr 5.

When the Global Polio Eradication Initiative (GPEI) began in 1988, cases of poliomyelitis were reported from 125 countries. Since then, only Afghanistan, Nigeria, and Pakistan have experienced uninterrupted transmission of wild poliovirus (WPV). The primary means of detecting poliovirus is through surveillance for acute flaccid paralysis (AFP) among children aged <15 years with testing of stool specimens for WPV and vaccine-derived polioviruses (VDPVs) in World Health Organization (WHO)-accredited laboratories of the Global Polio Laboratory Network (GPLN) (1,2). Read More

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http://dx.doi.org/10.15585/mmwr.mm6813a4DOI Listing
April 2019
2 Reads

Maternal pertussis vaccination and its effects on the immune response of infants aged up to 12 months in the Netherlands: an open-label, parallel, randomised controlled trial.

Lancet Infect Dis 2019 Apr 27;19(4):392-401. Epub 2019 Mar 27.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands. Electronic address:

Background: Maternal tetanus, diphtheria, and acellular pertussis (Tdap) vaccination offers protection for neonates against clinical pertussis until primary vaccinations, but maternal antibodies also interfere with infants' immune responses to primary vaccinations. We investigated the effect of maternal Tdap vaccination on the pertussis antibody responses of infants starting primary vaccinations at age 3 months.

Methods: In an open-label, parallel, randomised, controlled trial, pregnant women aged 18-40 years with a low risk of pregnancy complications were recruited through independent midwives at 36 midwife clinics in the Netherlands and received Tdap vaccination either at 30-32 weeks of pregnancy (maternal Tdap group) or within 48 h after delivery (control group). Read More

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http://dx.doi.org/10.1016/S1473-3099(18)30717-5DOI Listing
April 2019
3 Reads

X-linked agammaglobulinemia (XLA):Phenotype, diagnosis, and therapeutic challenges around the world.

World Allergy Organ J 2019 22;12(3):100018. Epub 2019 Mar 22.

Division of Allergy Immunology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Background: X-linked agammaglobulinemia is an inherited immunodeficiency recognized since 1952. In spite of seven decades of experience, there is still a limited understanding of regional differences in presentation and complications. This study was designed by the Primary Immunodeficiencies Committee of the World Allergy Organization to better understand regional needs, challenges and unique patient features. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19394551193010
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http://dx.doi.org/10.1016/j.waojou.2019.100018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439403PMC
March 2019
3 Reads

Poliomyelitis in ancient Greece (5th century BC)?

Neurology 2019 Apr;92(14):678-679

From Centre for Cretan Archaeology (E.V.), Department of Humanities (DISUM), University of Catania; National Etruscan Museum of Villa Giulia (V.N.), Rome; Santa Lucia Clinic-Polydiagnostic Medical Centre (E.V., F.M.G.), Siracusa, Italy; and Archaeology (F.M.G.)., College of Humanities, Arts and Social Sciences, Flinders University, Adelaide, Australia.

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http://dx.doi.org/10.1212/WNL.0000000000007350DOI Listing
April 2019
1 Read

Virus-like particle vaccines for poliovirus types 1, 2, and 3 with enhanced thermostability expressed in insect cells.

Vaccine 2019 Apr 25;37(17):2340-2347. Epub 2019 Mar 25.

Sino-French Hoffmann Institute of Immunology, State Key Laboratory of Respiratory Disease, College of Basic Medical Science, Guangzhou Medical University, Guangzhou, China; Guangdong South China Vaccine Co. Ltd, Guangzhou, China. Electronic address:

Poliovirus (PV) is a pathogen that causes poliomyelitis, which may lead to paralysis and fatality. Inactivated PV vaccines (IPVs) and live-attenuated oral PV vaccines (OPVs) are currently used to defend against PV worldwide. Vaccines must be developed in a PV-free environment given the biosafety issues associated with OPV and IPV production and to eradicate PV globally. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.03.031DOI Listing
April 2019
13 Reads

[An investigation of vaccination in children with human immunodeficiency virus infection].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Mar;21(3):199-202

National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

Objective: To investigate the status of vaccination in children with human immunodeficiency virus (HIV) infection.

Methods: A questionnaire survey was performed in 148 children in Hunan province, China who were registered in China's Acquired Immune Deficiency Syndrome Comprehensive Response Information Management System up to December 31, 2016 and were aged <15 years at the time of confirmed diagnosis of HIV infection. The information on vaccination, diagnosis of HIV infection, and diagnosis and treatment of related diseases was collected. Read More

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March 2019
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Self-perceived mobility in immigrants in Sweden living with the late effects of polio.

Disabil Rehabil 2019 Mar 23:1-6. Epub 2019 Mar 23.

a Rehabilitation Medicine, Department of Clinical Neuroscience , Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.

Purpose: To investigate outdoor mobility of immigrants in Sweden who are living with the late effects of polio.

Materials And Methods: A total of 145 patients with late effects of polio born outside the Nordic region were identified at an outpatient polio clinic. Of these, 74 completed a questionnaire about their mobility and independence in daily life, self-perceived pain and depression, vocational status, mobility assistive devices/aids, transportation modes and driving. Read More

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https://www.tandfonline.com/doi/full/10.1080/09638288.2019.1
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http://dx.doi.org/10.1080/09638288.2019.1585488DOI Listing
March 2019
4 Reads

University of Alberta Hospital Acute and Convalescent Polio Care and the Reintegration of Polio Patients into Albertan Communities, 1953-80.

Authors:
Geraldine Huynh

Can Bull Med Hist 2019 22;36(1):112-130. Epub 2019 Mar 22.

Faculty of Medicine and Dentistry, University of Alberta.

Following Canada's largest polio epidemic in 1953, Station 67 at the University of Alberta Hospital (UAH) in Edmonton became home to patients who contracted the virus. As young as nine years old, some of these patients lived at the UAH for more than three decades. Akin to wartime services, the epidemic banded together families, patients, doctors, nurses, community members, and later respiratory, physical, and occupational therapists. Read More

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http://dx.doi.org/10.3138/cbmh.249-022018DOI Listing
March 2019
1 Read

Test-retest reliability of the Re-Integration to Normal Living Index (RNL-I) to assess perceived participation in adults with late effects of polio.

PM R 2019 Mar 22. Epub 2019 Mar 22.

Department of Health Sciences, Lund University, Lund, Sweden.

Background: Many individuals with late effects of polio have difficulties participating in daily activities. The Re-integration to Normal Living Index (RNL-I) is a self-report questionnaire that evaluates perceived participation, but knowledge of the test-retest reliability and measurement errors in this population is lacking.

Objective: To evaluate the test-retest reliability of the RNL-I in adults with late effects of polio. Read More

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http://dx.doi.org/10.1002/pmrj.12162DOI Listing
March 2019
2 Reads

Clearance of psoriasis after ischemic stroke.

Cutis 2018 Feb;102(2):74-76

Dermatology Research and Education Foundation, Irvine, California, USA.

The role of the nervous system in the pathogenesis of psoriasis is not well elucidated. However, its involvement is clinically apparent with sparing of areas affected by neurologic disease, such as poliomyelitis, and remission of psoriasis in cases of nerve damage. Several neuropeptides, including substance P (SP), nerve growth factor, calcitonin gene-related peptide, and vasoactive intestinal peptide have been hypothesized to play a part in the development of psoriasis and its symptoms. Read More

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February 2018
1 Read

Acute Flaccid Myelitis: Lessons From Polio.

Authors:
Janet R Gilsdorf

J Pediatric Infect Dis Soc 2019 Mar 19. Epub 2019 Mar 19.

Department of Pediatrics, University of Michigan Medical School, Ann Arbor.

With the eradication of poliomyelitis in the United States, the appearance of acute flaccid myelitis outbreaks has raised questions regarding their causation. Review of the epidemiology, clinical aspects, and laboratory findings of bygone cases of poliomyelitis have revealed shows important similarities with those of newer cases of acute flaccid myelitis. Many occurrences are preceded by an apparent viral illness, and a number of viruses, particularly enteroviruses A71 and D68, can be isolated from respiratory or stool specimens. Read More

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http://dx.doi.org/10.1093/jpids/piz017DOI Listing
March 2019
1 Read

Integrated Safety Profile of a New Approved, Fully Liquid DTaP5-HB-IPV-Hib Vaccine.

Pediatr Infect Dis J 2019 Apr;38(4):439-443

From the Merck & Co., Inc., Kenilworth, NJ.

Background: DTaP5-HB-IPV-Hib is a fully liquid, hexavalent vaccine containing a 5-antigen pertussis component, approved since 2016 in Europe [Vaxelis; DTaP5-HB-IPV-Hib vaccine: Diphtheria, tetanus, pertussis (5 acellular components: pertussis toxoid [PT], filamentous haemagglutinin [FHA], pertactin (PRN), and fimbriae Types 2 and 3 [FIM]), hepatitis B (recombinant DNA: rDNA), poliomyelitis (inactivated) and Haemophilus influenzae type b conjugate vaccine (adsorbed); MCM Vaccine B.V., The Netherlands] for primary and booster vaccination in infants and toddlers against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis and invasive diseases caused by Haemophilus influenzae type b. Read More

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http://dx.doi.org/10.1097/INF.0000000000002257DOI Listing
April 2019
3 Reads

Interactions Between Enteroviruses and the Inflammasome: New Insights Into Viral Pathogenesis.

Front Microbiol 2019 25;10:321. Epub 2019 Feb 25.

NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Enteroviruses (EVs) have emerged a substantial threat to public health. EVs infection range from mild to severe disease, including mild respiratory illness, diarrhea, poliomyelitis, hand, foot, and mouth disease, aseptic meningitis, and encephalitis. In the Asia-Pacific region, for example, one of the best studied enterovirus 71 (EV71) has been associated with pandemics of hand, foot, and mouth disease (HFMD) in children, particularly those under the age of five. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398425PMC
February 2019
2 Reads

Update on Vaccine-Derived Poliovirus Outbreaks - Democratic Republic of the Congo and Horn of Africa, 2017-2018.

MMWR Morb Mortal Wkly Rep 2019 Mar 8;68(9):225-230. Epub 2019 Mar 8.

Widespread use of live attenuated (Sabin) oral poliovirus vaccine (OPV) has resulted in marked progress toward global poliomyelitis eradication (1). However, in underimmunized populations, extensive person-to-person transmission of Sabin poliovirus can result in genetic reversion to neurovirulence and paralytic vaccine-derived poliovirus (VDPV) disease (1). This report updates (as of February 26, 2019) previous reports on circulating VDPV type 2 (cVDPV2) outbreaks during 2017-2018 in the Democratic Republic of the Congo (DRC) and in Somalia, which experienced a concurrent cVDPV type 3 (cVDPV3) outbreak* (2,3). Read More

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http://dx.doi.org/10.15585/mmwr.mm6809a2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421971PMC
March 2019
2 Reads

Strengthening the Acute Flaccid Paralysis (AFP) Surveillance Component of the Polio Eradication Initiative through Short Message Service (SMS) Reminders; Experience from Sokoto State, Nigeria 2014.

J Immunol Sci 2018 Jul;Suppl(10):68-74

World Health Organization, Geneva, Switzerland.

Eradication of poliomyelitis remains a public health priority due to the paralytic effects of the virus on children and impact on global health system. However, existing gaps in surveillance can hinder eradication. Improved timeliness of identification and reporting of acute flaccid paralysis (AFP) cases with further confirmation of Wild Poliovirus (WPV) in stool samples, can help Nigeria achieve the performance indicators of non-polio AFP rate of ≥ 2/100,000 population aged < 15 years and ≥80% stool sample collection adequacy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398576PMC
July 2018
1 Read

Neurological Symptoms in Danes with a History of Poliomyelitis: Lifelong Follow-Up of Late Symptoms, their Association with Initial Symptoms of Polio, and Presence of Postpolio Syndrome.

Eur Neurol 2018 5;80(5-6):295-303. Epub 2019 Mar 5.

Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Rigshospitalet, University of Copenhagen, Glostrup, Denmark.

Background: Previous studies suggest that patients with a history of poliomyelitis (PM) later in life experience a variety of symptoms. These studies were carried out in patients who later in life were admitted to hospital or became members of polio societies and may therefore not be representative of all polio patients. Little data have been published concerning patients actually discharged from hospital with a diagnosis of acute paralytic PM. Read More

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http://dx.doi.org/10.1159/000497483DOI Listing
March 2019
4 Reads

Polio vaccination coverage and seroprevalence of poliovirus antibodies after the introduction of inactivated poliovirus vaccines for routine immunization in Japan.

Vaccine 2019 Mar 1;37(14):1964-1971. Epub 2019 Mar 1.

Department of Infectious Disease Surveillance Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, Japan.

In Japan, the oral poliovirus vaccine (OPV) was changed to 2 types of inactivated poliovirus vaccine (IPV), the standalone conventional IPV (cIPV) and the Sabin-derived IPV combined with diphtheria-tetanus-acellular pertussis vaccine (DTaP-sIPV), for routine immunization in 2012. We evaluated polio vaccination coverage and the seroprevalence of poliovirus antibodies using data from the National Epidemiological Surveillance of Vaccine-Preventable Diseases (NESVPD) from 2011 to 2015. Several years before the introduction of IPV in 2012, OPV administration for children was refused by some parents because of concerns about the risk of vaccine-associated paralytic poliomyelitis. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.02.034DOI Listing
March 2019
4 Reads

Isolation of known and potentially pathogenic tick-borne microorganisms from European ixodid ticks using tick cell lines.

Ticks Tick Borne Dis 2019 04 19;10(3):628-638. Epub 2019 Feb 19.

The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK; Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool Science Park IC2, 146 Brownlow Hill, Liverpool L3 5RF, UK. Electronic address:

Ticks harbour and, in many cases transmit to their vertebrate hosts, a wide variety of pathogenic, apathogenic and endosymbiotic microorganisms. Recent molecular analyses have greatly increased the range of bacterial species potentially associated with ticks, but in most cases cannot distinguish between surface contaminants, microorganisms present in the remains of the previous blood meal and truly intracellular or tissue-associated bacteria. Here we demonstrate how tick cell lines, primary cell cultures and organ cultures can be used to isolate and propagate bacteria from within embryonic and adult Ixodes ricinus, Dermacentor marginatus and Dermacentor reticulatus ticks originating from different parts of Europe. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2019.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446187PMC
April 2019
2 Reads

Talk to Patients About: Polio.

Authors:
Sean Price

Tex Med 2019 Feb 1;115(2):47. Epub 2019 Feb 1.

Polio once terrified Americans. In the late 1940s and early 1950s, the virus crippled around 35,000 Americans a year, according to the Centers for Disease Control and Prevention. Because polio often attacked abdominal muscles used to breathe, many died or permanently needed a respirator called an iron lung. Read More

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February 2019
5 Reads

NLRX1 regulates TNF-α-induced mitochondria-lysosomal crosstalk to maintain the invasive and metastatic potential of breast cancer cells.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 23. Epub 2019 Feb 23.

Department of Biochemistry, Faculty of Science, The M.S. University of Baroda, Vadodara 390002, Gujarat, India. Electronic address:

An increased level of proinflammatory cytokines, including TNF-α in tumor microenvironment regulates the bioenergetic capacity, immune evasion and survival of cancer cells. Emerging evidences suggest that mitochondrial immune signaling proteins modulates mitochondrial bioenergetic capacity, in addition to the regulation of innate immune response. The optimal oxidative phosphorylation (OxPhos) capacity is required for the maintenance of functional lysosomes and autophagy flux. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.018DOI Listing
February 2019
6 Reads
4.882 Impact Factor

Long-term outcome after Lambrinudi arthrodesis: How they're doing after three decades.

J Orthop Surg (Hong Kong) 2019 Jan-Apr;27(1):2309499019826492

Department of Orthopaedics and Traumatology, Duchess of Kent Children's Hospital, Hong Kong.

Objective:: The aim of the study is to investigate the long-term outcome of patients who received Lambrinudi arthrodesis for severe equinovarus deformities.

Methods:: This is a single-center, retrospective study of patients who received Lambrinudi triple arthrodesis of the foot. Both clinical and radiological information were analyzed. Read More

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http://dx.doi.org/10.1177/2309499019826492DOI Listing
February 2019
2 Reads

Immunogenicity of plant-produced porcine circovirus-like particles in mice.

Plant Biotechnol J 2019 Feb 21. Epub 2019 Feb 21.

Biopharming Research Unit, Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.

Porcine circovirus type 2 (PCV-2) is the main causative agent associated with a group of diseases collectively known as porcine circovirus-associated disease (PCAD). There is a significant economic strain on the global swine industry due to PCAD and the production of commercial PCV-2 vaccines is expensive. Plant expression systems are increasingly regarded as a viable technology to produce recombinant proteins for use as pharmaceutical agents and vaccines. Read More

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http://dx.doi.org/10.1111/pbi.13097DOI Listing
February 2019
1 Read

The immunomodulatory effects of measles-mumps-rubella vaccination on persistence of heterologous vaccine responses.

Immunol Cell Biol 2019 Feb 21. Epub 2019 Feb 21.

Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.

It is proposed that measles-containing vaccines have immunomodulatory effects which include a reduction in all-cause childhood mortality. The antibody response to heterologous vaccines provides a means to explore these immunomodulatory effects. This is the first study to investigate the influence of measles-mumps-rubella (MMR) vaccine on the persistence of antibodies to a broad range of heterologous infant vaccinations given in the first year of life. Read More

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http://dx.doi.org/10.1111/imcb.12246DOI Listing
February 2019
5 Reads

Distal Femoral Flexion Closing Wedge Osteotomy for Treatment of Failed Chronic Distal Femoral Extension Osteotomy in a Patient With Poliomyelitis.

J Surg Orthop Adv 2018 ;27(4):329-334

Department of Orthopaedic Surgery, Sports Medicine, and Shoulder Surgery, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts; e-mail:

The goal of orthopaedic treatment in chronic poliomyelitis is to address the functional impairments resulting from muscular imbalances and bony deformities. The most common knee deformity is a flexion contracture seen in the sagittal plane. Inappropriate or overcorrections of these deformities can have devastating long-term consequences. Read More

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January 2018
1 Read

[The eradication of infectious viral diseases endangered by advances in synthetic biology].

Med Sci (Paris) 2019 Feb 18;35(2):181-186. Epub 2019 Feb 18.

Institut de recherche biomédicale des armées, Unité Biothérapies anti-infectieuses et immunité, Département Microbiologie et maladies infectieuses, 1, place général Valérie André, 91220 Brétigny-sur-Orge, France - Institut Pasteur, unité génomique virale et vaccination, CNRS UMR-3569, 25, rue du Docteur Roux, 75015 Paris, France - École du Val-de-Grâce, 74, boulevard de Port-Royal, 75005 Paris, France.

The eradication of infectious diseases is one of the oldest dreams of mankind. It has been materialized only once in History with smallpox in 1980. Considerable efforts are being developed against poliomyelitis viruses since 1988, but the ultimate goal of eradication is not yet achieved. Read More

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http://dx.doi.org/10.1051/medsci/2019005DOI Listing
February 2019
1 Read

Long-term dynamics of Ixodes persulcatus (Acari: Ixodidae) abundance in the north-west of its range (Karelia, Russia).

Exp Appl Acarol 2019 Feb 13;77(2):229-240. Epub 2019 Feb 13.

Chumakov Federal Scientific Center for Research and Development of Immune and Biological Products, Russian Academy of Sciences, bldg. 1, 8, Institute for Poliomyelitis, Moscow, 108819, Russia.

The article presents the results of long-term observations of variations in the abundance of Ixodes persulcatus, carried out since 1982, in the middle taiga subzone of Karelia. Adult questing ticks were collected from vegetation following standard flagging procedures. The time series was evaluated by singular spectrum analysis. Read More

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http://dx.doi.org/10.1007/s10493-019-00342-yDOI Listing
February 2019

Iterative Excretion of Human Cosaviruses from Different Genotypes Associated with Combined Immunodeficiency Disorder.

Intervirology 2018 6;61(5):247-254. Epub 2019 Feb 6.

WHO Regional Reference Laboratory for Poliomyelitis and Measles, Laboratory of Clinical Virology, Pasteur Institute of Tunis, University of Tunis El Manar, Tunis, Tunisia,

Background: Human cosaviruses (HCoSVs) are newly discovered enteric viruses in the Picornaviridae family. They have been described in non-polio acute flaccid paralysis, diarrheal patients, and healthy individuals. They remain rarely documented in immunodeficient patients. Read More

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http://dx.doi.org/10.1159/000495182DOI Listing
February 2019
4 Reads

Assessment of the Parameters of Adaptive Cell-Mediated Immunity in Naïve Common Marmosets (Callithrix jacchus).

Acta Naturae 2018 Oct-Dec;10(4):63-69

Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, premises 8, bldg. 1, Village of Institute of Poliomyelitis, Settlement "Moskovskiy", Moscow, 108819, Russia.

Common marmosets are small New World primates that have been increasingly used in biomedical research. This report presents efficient protocols for assessment of the parameters of adaptive cell-mediated immunity in common marmosets, including the major subpopulations of lymphocytes and main markers of T- and B-cell maturation and activation using flow cytometry with a multicolor panel of fluorescently labelled antibodies. Blood samples from eight common marmosets were stained with fluorescently labeled monoclonal antibodies against their population markers (CD45, CD3, CD20, CD4, CD8) and lymphocyte maturation and activation markers (CD69, CD62L, CD45RO, CD107a and CD27) and analyzed by flow cytometry. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351028PMC
February 2019
2 Reads

Molecular Evolution of Human Adenovirus (HAdV) Species C.

Sci Rep 2019 Jan 31;9(1):1039. Epub 2019 Jan 31.

Hannover Medical School, Institute of Virology, Hannover, Germany.

Currently, 88 different Human Adenovirus (HAdV) types are grouped into seven HAdV species A to G. Most types (57) belong to species HAdV-D. Recombination between capsid genes (hexon, penton and fiber) is the main factor contributing to the diversity in species HAdV-D. Read More

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http://dx.doi.org/10.1038/s41598-018-37249-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355881PMC
January 2019
2 Reads

Resurgence of Vaccine-Preventable Diseases in Venezuela as a Regional Public Health Threat in the Americas.

Emerg Infect Dis 2019 Apr 17;25(4):625-632. Epub 2019 Apr 17.

Venezuela's tumbling economy and authoritarian rule have precipitated an unprecedented humanitarian crisis. Hyperinflation rates now exceed 45,000%, and Venezuela's health system is in free fall. The country is experiencing a massive exodus of biomedical scientists and qualified healthcare professionals. Read More

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http://dx.doi.org/10.3201/eid2504.181305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433037PMC
April 2019
2 Reads

Mandatory vaccination of infants in France: Is that the way forward?

Eur J Gen Pract 2019 Jan 23;25(1):49-54. Epub 2019 Jan 23.

a Conseil Scientifique du Collège National des Généralistes Enseignants (CNGE) , Paris , France.

In this opinion paper, the authors argue that the extension of mandatory immunization of infants up to two years of age from three diseases (diphtheria, tetanus, poliomyelitis) to 11 diseases, introduced in France in January 2018, is not a sustainable response to the challenge of controlling vaccine-preventable diseases. In France in 2017, infant immunization coverage (IC) rates were sufficiently high or increasing (hepatitis B), except for measles, mumps and rubella (MMR) and meningococcus C disease. Even if vaccination obligation makes it possible to achieve the MMR IC objectives among infants, communication programmes and supported advice from GPs are essential for the catch-up of susceptible adults to obtain herd immunity. Read More

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http://dx.doi.org/10.1080/13814788.2018.1561849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394317PMC
January 2019
5 Reads

Post-marketing surveillance to assess the safety and tolerability of a combined diphtheria, tetanus, acellular pertussis and inactivated poliovirus vaccine (DTaP-IPV) in Korean children.

Hum Vaccin Immunother 2019 Jan 22:1-9. Epub 2019 Jan 22.

e Department of Pediatrics , Korea University College of Medicine , Seoul , Republic of Korea.

Infanrix-IPV (GSK, Belgium) is a diphtheria, tetanus, acellular pertussis, and inactivated poliovirus combination vaccine (DTaP-IPV) licensed in many countries including Korea. In accordance with Korean regulations, we conducted a post-marketing surveillance (PMS) to evaluate the safety of DTaP-IPV administered to Korean children in routine immunization schedules. Children aged <7 years receiving at least one dose of DTaP-IPV either as part of a primary (3-dose) vaccination series or as a subsequent booster were enrolled. Read More

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http://dx.doi.org/10.1080/21645515.2019.1572406DOI Listing
January 2019
10 Reads

Achieving the end game: employing "vaccine diplomacy" to eradicate polio in Pakistan.

BMC Public Health 2019 Jan 17;19(1):79. Epub 2019 Jan 17.

Department of Anesthesiology and Division of Infectious Diseases and Global Public Health, University of California, San Diego School of Medicine, San Diego, CA, USA.

Background: On April 28, 2014, the World Health Organization (WHO) declared polio a "Public Health Emergency of International Concern" (PHIC) under the authority of the International Health Regulations. Although polio has been eradicated from nearly every nation on earth, Pakistan is one of three countries where wild polio and vaccine-derived polio strains remain, thwarting global eradication efforts.

Aims: Polio eradication progress is complicated by security and conflict issues at the border area between Pakistan and Afghanistan. Read More

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https://bmcpublichealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12889-019-6393-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337835PMC
January 2019
9 Reads
2.264 Impact Factor

[Chinese study and production of poliomyelitis vaccine : an interview with Gu Fangzhou].

Authors:
F Z Gu R T Fan

Zhonghua Yi Shi Za Zhi 2018 Sep;48(5):304-312

National Library of China, China Memory Project Center, Beijing, 100081, China.

Polio once was a problem that plagued the world in the 1950s, and it was also a serious problem in China. Chinese medical scientists such as Gu Fangzhou went abroad to study.After returned to China, they kept carrying research work and making production test in a tough environment, and developed a technical route and immunization strategy suitable for China. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0255-7053.2018.05.008DOI Listing
September 2018
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Outcome of femoral fractures in poliomyelitis patients.

Int Orthop 2019 Jan 15. Epub 2019 Jan 15.

Orthopedic Trauma Service, Hadassah Hebrew University Hospital, Jerusalem, Israel.

Background And Purpose: As patients who were afflicted with poliomyelitis during the outbreaks in the past are aging, lower extremity osteoporotic fractures are becoming more frequent. Fixation in deformed, porotic bone, coupled with muscle weakness and imbalance creates a unique challenge when treating these fractures as does their reduced rehabilitation potential. The aim of this study was to investigate the outcome of femoral fractures in surviving poliomyelitis patients. Read More

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http://dx.doi.org/10.1007/s00264-019-04285-2DOI Listing
January 2019
2 Reads

Vaccination coverage in Lebanon following the Syrian crisis: results from the district-based immunization coverage evaluation survey 2016.

BMC Public Health 2019 Jan 14;19(1):58. Epub 2019 Jan 14.

Ministry of Public Health, Beirut, Lebanon.

Background: Following the Syrian crisis, a substantial influx of Syrian refugees into Lebanon posed new challenges to optimal vaccination coverage for all children residing in the country. In 2016, the district-based immunization coverage evaluation survey (CES) assessed routine immunization coverage at the district level in Lebanon among children aged 12-59 months.

Methods: A cross-sectional multistage cluster survey was conducted in all of Lebanon (with the exception of the Nabatieh district) using the World Health Organization (WHO) recommended Expanded Programme on Immunization (EPI) methodology adapted to the local context. Read More

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https://bmcpublichealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12889-019-6418-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332691PMC
January 2019
8 Reads

Metagenomic analysis identifies human adenovirus 31 in children with acute flaccid paralysis in Tunisia.

Arch Virol 2019 Mar 10;164(3):747-755. Epub 2019 Jan 10.

Pathogen Discovery Laboratory and Biology of Infection Unit, Inserm U1117, Institut Pasteur, 28 rue du Dr Roux, 75015, Paris, France.

A variety of viruses can cause acute flaccid paralysis (AFP). However, the causative agent, sometimes, remains undetermined. Metagenomics helps in identifying viruses not diagnosed by conventional methods. Read More

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http://dx.doi.org/10.1007/s00705-018-04141-5DOI Listing
March 2019
3 Reads
2.282 Impact Factor

First case in China of vaccine-associated poliomyelitis after sequential Inactivated and bivalent oral polio vaccination.

Vaccine 2019 Jan 7;37(5):751-754. Epub 2019 Jan 7.

School of Social Development and Public Policy, Beijing Normal University, China. Electronic address:

A 16 week newborn vaccinated with bOPV 4 weeks after his first routine IPV vaccination. Nineteen days later, asymmetrical paralysis was developed on his legs, and it was diagnosed to be VAPP. Perianal abscess is suspected to be a risk factor based on some limited results of retrospective studies in China. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X183169
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http://dx.doi.org/10.1016/j.vaccine.2018.12.022DOI Listing
January 2019
15 Reads

Factors associated with falls in Japanese polio survivors.

Disabil Rehabil 2019 Jan 7:1-5. Epub 2019 Jan 7.

a Department of Rehabilitation Medicine , Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto , Japan.

Purpose: To identify factors associated with falls in Japanese polio survivors and assess the extent of their impact.

Materials And Methods: Subjects were 128 polio survivors. Fall history and fear of falling, lower limb muscle strength, gait ability (determined by walking speed and number of steps per day), post-polio syndrome incidence, and orthosis or walking aid use were assessed, and factors associated with falls were identified using logistic regression analysis. Read More

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http://dx.doi.org/10.1080/09638288.2018.1537381DOI Listing
January 2019
2 Reads

[Immunisation schedule of the Spanish Association of Paediatrics: 2019 recommendations].

An Pediatr (Barc) 2019 Jan;90(1):56.e1-56.e9

Hospital Universitario 12 de Octubre, Madrid, España; Facultad de Medicina, Departamento de Pediatría, Universidad Complutense de Madrid, España.

The Advisory Committee on Vaccines of the Spanish Association of Paediatrics annually publishes the immunisation schedule considered optimal for children resident in Spain, according to available evidence on current vaccines. As regards funded immunisations, the 2+1 strategy (2, 4, 11 months) with hexavalent (DTPa-IPV-Hib-HB) and 13-valent pneumococcal vaccines are recommended. Administration of the 6-year booster dose with DTPa is recommended, with a poliomyelitis dose for children who had received the 2+1 scheme, as well as Tdap vaccine for adolescents and pregnant women in every pregnancy between 27 and 32 weeks gestation. Read More

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http://dx.doi.org/10.1016/j.anpedi.2018.10.006DOI Listing
January 2019
6 Reads

Paediatric orthopaedics through paintings.

J Child Orthop 2018 Dec;12(6):647-651

Department of Orthopaedics and Traumatology, Sivas Numune Hospital, Sivas, Turkey.

Purpose: Some famous artistic representations created throughout the centuries can reveal a hidden or mysterious diagnosis of some diseases and these paintings have always drawn the attention of physicians interested in art. Artistic illustration of a child with a malformation or disability can reflect the characteristic appearance of a disease and its historic perspective. Some articles have revealed the definite diagnosis of a child with achondroplasia through portraits of dwarfs and some studies have discussed the secret diagnosis of a crippled child with Pes Equinovarus or poliomyelitis. Read More

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https://online.boneandjoint.org.uk/doi/10.1302/1863-2548.12.
Publisher Site
http://dx.doi.org/10.1302/1863-2548.12.180141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293333PMC
December 2018
8 Reads