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Pancreas 2019 Feb 8. Epub 2019 Feb 8.

From the Division of Pediatric Gastroenterology, Department of Gastroenterology.

Objectives: Endoscopic ultrasound (EUS) is a minimally invasive pancreatic imaging modality. We evaluated children with idiopathic acute pancreatitis (IAP) and acute recurrent pancreatitis (ARP) for changes of chronicity (Rosemont criteria) and biliary risk factors. Diagnostic yield of simultaneously performed transabdominal ultrasonography (TUS) was compared with EUS. Read More

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(2):161-167

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University.

We herein report a rare case of fulminant type 1 diabetes mellitus (FT1DM) following acute pancreatitis and hypoglycemia, in which the pancreas was evaluated by serial computed tomography (CT). A 30-year-old male presented to a local hospital with a two-day history of abdominal pain and was diagnosed with acute pancreatitis based on elevated serum amylase and peripancreatic fluid collection on CT images. The patient developed sudden hypoglycemia (plasma glucose, 45mg/dL;serum C-peptide, 3. Read More

J Gastrointest Surg 2019 Feb 7. Epub 2019 Feb 7.

Department of Surgery, Indiana University School of Medicine, 545 Barnhill Drive EH 519, Indianapolis, IN, 46202, USA.

Background: Necrotizing pancreatitis (NP) is a severe systemic inflammatory process. We have observed a high incidence of venous thromboembolism (VTE) in NP patients. However, remarkably few data exist to document the true incidence of VTE-including splanchnic vein thrombosis (SVT), extremity deep venous thrombosis (eDVT), and pulmonary embolism (PE)-in NP. Read More

Front Immunol 2019 24;10:28. Epub 2019 Jan 24.

Division of Surgical Oncology, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.

Neutrophil extracellular traps (NETs) are generated when activated neutrophils, driven by PAD4, release their DNA, histones, HMGB1, and other intracellular granule components. NETs play a role in acute pancreatitis, worsening pancreatic inflammation, and promoting pancreatic duct obstruction. The autophagy inhibitor chloroquine (CQ) inhibits NET formation; therefore, we investigated the impact of CQ mediated NET inhibition in murine models of pancreatitis and human correlative studies. Read More

J Immunother Cancer 2019 Feb 6;7(1):31. Epub 2019 Feb 6.

Departments of Gastroenterology, Hepatology & Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Immune checkpoint inhibitor (ICI)-induced pancreatic injury (ICIPI) is not well documented in the literature. We aimed to describe the clinical characteristics and outcomes of patients who developed ICIPI.

Methods: We reviewed the medical records of consecutive patients who had a confirmed diagnosis of ICIPI (Common Terminology Criteria for Adverse Events grade ≥ 3 lipase elevation with or without clinical symptoms) from April 2011 through April 2018. Read More

Can Assoc Radiol J 2019 Feb;70(1):52-61

Department of Diagnostic Radiology, Khoo Teck Puat Hospital, Singapore.

Excess alcohol consumption is a leading cause of preventable morbidity and mortality globally. The pattern of consumption of alcoholic beverages has changed in our society in the recent past, with binge drinking becoming more and more common, especially among young adults. Abdominal pain following alcohol consumption can be secondary to a wide range of pathologies, the treatment algorithm of which can range from medical supportive treatment to more invasive life-saving procedures such as transarterial embolization and emergency laparotomy. Read More

Insights Imaging 2019 Jan 28;10(1). Epub 2019 Jan 28.

Digestive Endoscopy, "Luigi Sacco" University Hospital, Via G.B. Grassi 74, 20157, Milan, Italy.

In recent years, technological advancements including endoscopic ultrasound (EUS) guidance and availability of specifically designed stents further expanded the indications and possibilities of interventional endoscopy. Although technically demanding and associated with non-negligible morbidity, advanced pancreatic endoscopic techniques now provide an effective minimally invasive treatment for complications of acute and chronic pancreatitis.Aiming to provide radiologists with an adequate familiarity, this pictorial essay reviews the indications, techniques, results and pre- and post-procedural cross-sectional imaging appearances of advanced endoscopic interventions on the pancreas and pancreatic ductal system. Read More

Radiologe 2019 Feb;59(2):114-125

Klinik und Poliklinik für Radiologie, Klinikum der Ludwig-Maximilians-Universität München, Campus Grosshadern, Marchioninistr. 15, 81377, München, Deutschland.

Clinical/methodical Issue: Diagnostic imaging plays a crucial role in the assessment and stratification of pathologic conditions causing acute abdomen. This report provides information on etiology, clinical manifestations and therapeutic options for six common diseases resulting in acute abdomen-appendicitis, cholecystitis, bowel obstruction, diverticulitis, acute pancreatitis, and viscus perforation.

Performance: Besides initial ultrasound, CT scans often represent the imaging gold standard for the diagnostic evaluation of acute abdomen. Read More

Abdom Radiol (NY) 2019 Jan 25. Epub 2019 Jan 25.

Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Purpose: Early diagnosis of chronic pancreatitis (CP) remains elusive. Preliminary data suggest that MR elastography (MRE) may have diagnostic value in the identification of CP. We sought to measure pancreas stiffness by MRE in healthy children and to compare measured values to stiffness values in pediatric patients with acute recurrent pancreatitis (ARP) or CP. Read More

Pancreatology 2019 Jan 3. Epub 2019 Jan 3.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background And Aims: Annular pancreas (AnnP) is a rare congenital abnormality that results from the presence of a complete or partial ring of pancreatic tissue surrounding the descending portion of the duodenum. While the clinical presentation and management of AnnP in neonates and infants has been well described, the complete spectrum of clinical presentation of AP in adults is not very clear. We aimed to describe the clinical spectrum of presentation and management of adult patients with AnnP. Read More

Cureus 2018 Nov 12;10(11):e3577. Epub 2018 Nov 12.

Interventional Radiology, University of Florida College of Medicine, Jacksonville, USA.

Percutaneous cholangiography is typically performed via a transhepatic approach and is reserved for patients with contraindications to traditional cholangiogram imaging modalities. For those with suspected cholelithiasis or choledocholithiasis who cannot undergo magnetic resonance imaging for diagnosis, percutaneous cholecystostomy with cholangiogram is a viable option. Endoscopic retrograde cholangiopancreatography may also be precluded due to anatomic or obstructive limitations, in which case, percutaneous transhepatic cholangiography (PTC) may be indicated for diagnosis. Read More

J Radiol Case Rep 2018 May 31;12(5):12-18. Epub 2018 May 31.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, via Vetoio, L'Aquila, Italy.

Pancreatic pseudoaneurysms represent relatively rare but potentially lethal complications of acute or chronic pancreatitis, involving several visceral arteries. Due to their intrinsic instability and subsequent high risk of massive bleeding, these lesions require prompt treatment, regardless of the size of the pseudoaneurysm. First option of treatment is today represented by transcatheter embolization; this treatment, in fact, shows higher rates of clinical and technical success and lower recurrence rates than conventional surgery. Read More

J Radiol Case Rep 2018 Oct 31;12(10):11-16. Epub 2018 Oct 31.

Department of Radiology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Annular pancreas is a rare congenital condition in which tissue from the head of the pancreas partially or completely surrounds the second part of the duodenum. This condition has a variable clinical presentation in adults and children. Radiologists should be aware of the imaging findings in adults as an annular pancreas can be overlooked or misdiagnosed in this patient population. Read More

Clin Endosc 2019 Jan 16. Epub 2019 Jan 16.

Division of Digestive and Liver Diseases, Columbia University Irving Medical Center, New York, NY, USA.

Background/aims: The aim of this study was to describe the diagnostic yield of endoscopic ultrasound (EUS) in patients with isolated elevated levels of amylase and/or lipase.

Methods: A retrospective chart review was conducted at a large academic medical center from 2000 to 2016. Patients were selected based on having elevated amylase, lipase, or both, but without a diagnosis of pancreatitis or known pancreatobiliary disease. Read More

Eur Radiol 2019 Jan 10. Epub 2019 Jan 10.

Department of Radiology, Hôpital Saint-Joseph, 185 Rue Raymond Losserand, 75014, Paris, France.

Purpose: To assess interobserver agreement when using the revised Atlanta classification (RAC) to categorize pancreatic and peripancreatic collections during the first month of acute pancreatitis (AP), and to correlate type of collection to outcome.

Material And Methods: This retrospective study of 115 consecutive patients admitted for 123 AP episodes, 178 CTs performed within the first month showed peripancreatic abnormalities. Each AP episode was classified as mild, moderately severe, or severe based on the RAC. Read More

Pancreas 2019 Feb;48(2):187-192

Radiology Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Objective: The aim of the study was to study the prevalence and characteristics of sinistral portal hypertension (SPH) in acute pancreatitis (AP) and its correlation with the severity of AP.

Methods: Retrospectively studied 633 patients with AP admitted to our institution and underwent magnetic resonance imaging (MRI). Diagnosis of SPH was based on clinical manifestations, laboratory tests, and MRI. Read More

Vnitr Lek 2018 ;64(10):949-952

Pancreatic steatosis is the name for a state characterized by an increased accumulation of fat in the pancreas. It is most frequently due to obesity and the metabolic syndrome, other etiological factors may include some congenital syndromes, toxic substances or viral diseases. Diagnostics is based on non-invasive imaging methods. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Dec;21(12):1361-1365

PLA Center for General Surgery, Key Laboratory of Pancreatic Injury and Repair of Sichuan Province, General Hospital of Chengdu Military Command, Chengdu 610083, China.Email:

The peripancreatic infection is a severe complication during severe acute pancreatitis. Early diagnosis, effective prevention and timely treatment are directly associated to prognosis. In recent years, with the promotion and application of the concept of damage control and the rapid development of imaging intervention techniques, the treatment for peripancreatic infection has become "multi-step, step-up" minimally invasive surgical strategy from early laparotomy. Read More

Case Rep Pediatr 2018 21;2018:8456503. Epub 2018 Nov 21.

Department of Pediatrics, Grande International Hospital, Dhapasi, Kathmandu, Nepal.

Background: Acute pancreatitis (AP) coexisting with acute hepatitis (AH) in children is uncommon. Moreover, a single bacterial cause explaining both the complications is even rarer. Despite familiarity with the usual presentation of enteric fever, atypical presentations can go unnoticed. Read More

Cells 2018 Dec 20;8(1). Epub 2018 Dec 20.

Institute of Cell Biology, Beijing Normal University, Beijing 100875, China.

In acute pancreatitis, histones are released by infiltrating neutrophils, but how histones modulate pancreatic acinar cell function has not been investigated. We have examined histone modulation of rat pancreatic acini and pancreatic acinar tumor cell AR4-2J by calcium imaging. Histones were found to have no effect on calcium in pancreatic acini but blocked calcium oscillations induced by cholecystokinin or acetylcholine. Read More

Horm Metab Res 2018 Dec 20. Epub 2018 Dec 20.

School of Medicine, University of Auckland, Auckland, New Zealand.

The study was aimed to investigate gut hormone responses to mixed meal test in individuals with new-onset prediabetes or diabetes after acute pancreatitis (cases) compared with healthy controls, and the effect of body fat parameters. A total of 29 cases and 29 age- and sex-matched healthy controls were recruited. All participants were given standard mixed meal drink and blood samples were collected to measure dipeptidyl peptidase IV, gastric inhibitory peptide, glucagon like peptide-1, insulin, oxyntomodulin, and peptide YY. Read More

Pediatr Int 2018 Dec 19. Epub 2018 Dec 19.

Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.

Children with cancer are at increased risk of life-threatening emergencies, either from the cancer itself or related to the cancer treatment. These conditions need to be assessed and treated as early as possible to minimize morbidity and mortality. Cardiothoracic emergencies encompass a variety of pathologies, including pericardial effusion and cardiac tamponade, massive hemoptysis, superior vena cava syndrome, pulmonary embolism, and pneumonia. Read More

Ultrasound Med Biol 2019 Feb 13;45(2):579-585. Epub 2018 Dec 13.

Department of Radiology, Gifu University Graduate School of Medicine, Gifu, Japan.

Hydrogen peroxide (HO) has been reported to be an effective radiation sensitizer for various cancers. A combination therapy comprising fine-needle injection (FNI) of HO under endoscopic ultrasound (EUS) guidance and chemoradiation might improve treatment outcomes of pancreatic cancer; however, there have been no reports thus far. The aims of this study were to evaluate the feasibility and safety of EUS-FNI of HO into the pancreas using a porcine survival model. Read More

J Vet Intern Med 2019 Jan 11;33(1):79-88. Epub 2018 Dec 11.

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado.

Background: Acute pancreatitis in dogs is an under-diagnosed disease. Current diagnostic methods are insufficient at identifying sequelae and lack prognostic capability. Computed tomographic angiography (CTA) is accurate for diagnosis and prognostication of pancreatitis in humans. Read More

Turk J Med Sci 2018 Dec 12;48(6):1175-1181. Epub 2018 Dec 12.

Department of Emergency Medicine, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey

Background/aim: Soluble urokinase plasminogen activator receptor (suPAR) has been reported to have a positive correlation with the activation degree of the immune system. This study’s aim is to investigate the efficiency of SuPAR serum levels in acute pancreatitis (AP) patients in determining the severity of disease.

Materials And Methods: This prospective research involves patients who arrived at the emergency service, were over 18 years old, had nontraumatic abdominal pain and diagnosis of AP, and agreed to join the study. Read More

Med Ultrason 2018 Dec;20(4):427-435

Department of Internal Medicine 1, Friedrich-Alexander-University, Erlangen- Nuremberg, Germany.

Aims: Endosonography (EUS) is one of the main diagnostic tools for the differential diagnosis of pancreatic masses. The aim of our study was to describe the value of this technique in the work-up of solid pancreatic lesions, considering the influence of the morphological evidence of pancreatic inflammation in the diagnostic process.

Material And Methods: Retrospective analysis of prospectively collected data in our tertiary University center. Read More

Radiologia 2018 Dec 1. Epub 2018 Dec 1.

Servicio de Radiodiagnóstico, Hospital Universitario Doctor Peset, Valencia, España.

Chronic pancreatitis is a progressive fibroinflammatory process in the pancreas that causes permanent structural damage and leads to a deterioration in exocrine and endocrine function. The appearance of flares of acute pancreatitis, pseudocysts, and inflammatory masses all form part of the natural history of this disease. Vascular and / or digestive complications may occur, and patients with chronic pancreatitis have an increased risk of pancreatic adenocarcinoma. Read More

Eur Radiol 2018 Nov 28. Epub 2018 Nov 28.

Division of Experimental and Translational Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

Objectives: To evaluate the diagnostic performance of a dual-energy computed tomography (DECT)-based technique using iodine quantification and fat fraction analysis for the diagnosis of early acute pancreatitis METHODS: In this retrospective study, 45 patients (35 men and 10 women; mean age, 54.9 ± 14.0 years) with early acute pancreatitis were included. Read More

Am J Case Rep 2018 Nov 27;19:1410-1415. Epub 2018 Nov 27.

Vascular Surgery Clinic, AHEPA University General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

BACKGROUND Splenic aneurysms are rare, asymptomatic, and usually derive from previous surgical interventions. Endovascular repair is the best option, but when A-V shunt is present, open repair might be more suitable. CASE REPORT A 43-year-old man presented to the Internal Medicine Department of AHEPA University Hospital with symptoms of fever and ascites. Read More

Haematologica 2018 Nov 22. Epub 2018 Nov 22.

Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet;

Asparaginase-associated pancreatitis is a life-threatening toxicity to childhood acute lymphoblastic leukemia treatment. To elucidate genetic predisposition and asparaginase-associated pancreatitis pathogenesis, ten acute lymphoblastic leukemia trial groups contributed remission samples from patients aged 1.0-17. Read More

Dig Dis Sci 2019 Feb 22;64(2):553-560. Epub 2018 Nov 22.

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 YongWaizheng Street, Nanchang, 330006, Jiangxi Province, China.

Background And Aims: Pancreatic necrosis is a risk factor for poor prognosis of acute pancreatitis (AP). However, the associations between the findings on initial contrast-enhanced computed tomography (CT) of the pancreas and infected pancreatic necrosis (IPN) are unclear.

Methods: This was a retrospective cohort study. Read More

Scoliosis Spinal Disord 2018 8;13:24. Epub 2018 Nov 8.

1Anesthesia, Intensive Care and Pain Therapy, Istituto Ortopedico Rizzoli, via G. C. Pupilli 1, 40136 Bologna, Italy.

Background: Acute pancreatitis has been described as potential complication of both abdominal and non-abdominal surgeries. The pathogenetic mechanism underlying acute pancreatitis in spine surgery may include intraoperative hemodynamic instability causing prolonged splanchnic hypoperfusion, as well as mechanical compression of the pancreas due to scoliosis correction, with a higher risk in cases of more extended fusions, especially in young adults with lower body mass index (BMI).

Case Presentation: We report here a case of postoperative acute pancreatitis with benign evolution in a young female patient after the first and second surgery of a two-stage correction of right thoracic idiopathic scoliosis. Read More

Surg Res Pract 2018 22;2018:5216089. Epub 2018 Oct 22.

Department of General Surgery, Beilinson Hospital, Rabin Medical Center, Petach-Tikva, Israel.

Background: All patients with mild acute biliary pancreatitis should undergo early cholecystectomy. Whether routine common bile duct (CBD) imaging should be employed before the surgical procedure in these patients is a matter of current controversy. The aim of this study was to investigate the rate of detection of CBD stones using magnetic resonance cholangiopancreatography (MRCP) at different time intervals from admission. Read More

Eur Radiol 2018 Nov 9. Epub 2018 Nov 9.

Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, No. 63, Wenhua Road, Nanchong, 637000, Sichuan, China.

Objectives: To predict the recurrence of acute pancreatitis (AP) by constructing a radiomics model of contrast-enhanced computed tomography (CECT) at AP first attack.

Methods: We retrospectively enrolled 389 first-attack AP patients (271 in the primary cohort and 118 in the validation cohort) from three tertiary referral centers; 126 and 55 patients endured recurrent attacks in each cohort. Four hundred twelve radiomics features were extracted from arterial and venous phase CECT images, and clinical characteristics were gathered to develop a clinical model. Read More

Eur J Radiol 2018 Nov 5;108:13-20. Epub 2018 Sep 5.

Department of Neurosurgery, Shengjing Hospital, China Medical University, Shenyang, PR China. Electronic address:

Purpose: To assess the value of magnetic resonance elastography (MRE) in patients with autoimmune pancreatitis (AIP) and in the differentiation of AIP from pancreatic ductal adenocarcinoma (PDAC).

Method And Materials: This prospective study included 14 AIP patients, 26 PDAC patients, and 14 healthy volunteers. All participants underwent pancreatic MRE (40-Hz; 3 T scanner) at enrollment, and 7 AIP patients underwent a second MRE after initiation of steroid therapy. Read More

Insights Imaging 2018 Dec 2;9(6):925-941. Epub 2018 Nov 2.

Diagnostic and Interventional Radiology Department, ASST Santi Paolo e Carlo, Via A di Rudinì 8, 20142, Milan, Italy.

Performed on either an elective or urgent basis, cholecystectomy currently represents the most common abdominal operation due to the widespread use of laparoscopy and the progressively expanded indications. Compared to traditional open surgery, laparoscopic cholecystectomy minimised the duration of hospitalisation and perioperative mortality. Albeit generally considered safe, cholecystectomy may result in adverse outcomes with non-negligible morbidity. Read More

Anal Chem 2018 Nov 9;90(22):13775-13782. Epub 2018 Nov 9.

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals , Shandong Normal University , Jinan 250014 , China.

α-Amylase plays a key role in the physiological cycle of the human body; its function is constantly explored and used as an important indicator of some related diseases like acute pancreatitis, acute organophosphorus pesticide poisoning, and anxiety or depression. However, currently, including the assay kit, existing methods suffer from low sensitivity and time consumption or are indirect assays that require the aid of a tool enzyme or inhibitor of competitive substrates; hence, they are not suitable for the low activity and nondestructive sensing of α-amylase in body fluids. A rapid, highly sensitive, and simple direct α-amylase determination in human body fluids is still challenging. Read More

Medicine (Baltimore) 2018 Nov;97(44):e12976

Department of General Surgery, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Guadalajara, Jalisco, Mexico.

Cholecystectomy is the only definitive management of pancreatitis secondary to gallstone disease. Approximately 20% to 30% of patients with acute biliary pancreatitis (ABP) will have persistent common bile duct (CBD) stones. Therefore, choosing a method for the early diagnosis of choledocholithiasis is essential to reduce waiting days for surgery and hospital stay in these patients. Read More

Magn Reson Imaging Clin N Am 2018 Aug;26(3):439-450

Department of Radiology, University of Alabama at Birmingham, 619 19th Street South, JT N325, Birmingham, AL 35249, USA.

MR imaging is useful for diagnosing acute pancreatitis when the clinical situation is unclear, for elucidating the underlying cause of acute pancreatitis, for evaluating complications and disease severity, and for guiding intervention. MR imaging allows for noninvasive evaluation of the pancreatic parenchyma, biliary and pancreatic ducts, exocrine function, peripancreatic soft tissues, and vascular structures in a single examination. MR imaging is emerging as the imaging examination of choice in acute pancreatitis. Read More

Magn Reson Imaging Clin N Am 2018 Aug;26(3):323-344

Department of Radiology, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, 676 North St. Clair Street Suite 800, Chicago, IL 60611, USA. Electronic address:

Advances in MR imaging with optimization of hardware, software, and techniques have allowed for an increased role of MR in the identification and characterization of pancreatic disorders. Diffusion-weighted imaging improves the detection and staging of pancreatic neoplasms and aides in the evaluation of acute, chronic and autoimmune pancreatitis. The use of secretin-enhanced MR cholangiography improves the detection of morphologic ductal anomalies, and assists in the characterization of pancreatic cystic lesions and evaluation of acute and chronic pancreatitis. Read More

J Comput Assist Tomogr 2018 Oct 26. Epub 2018 Oct 26.

Department of Radiology, Thomas Jefferson University School of Medicine, Philadelphia, PA.

We report a case of a 29-year-old woman with a pancreatic lymphangioma who presented clinically as a case of acute pancreatitis. Lymphangiomas are benign tumors of vascular origin with lymphatic differentiation, most commonly found in the head and neck. Pancreatic lymphangiomas are extremely rare, accounting for only 1% of abdominal lymphangiomas, with approximately 60 cases reported in the literature. Read More

Zhongguo Dang Dai Er Ke Za Zhi 2018 Oct;20(10):844-847

Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China.

A boy aged 14 years had abdominal pain as the major manifestation, with elevated serum amylase and lipase. Abdominal ultrasound performed early after onset in another hospital showed enlargement of the pancreas and a reduction in echo. Magnetic resonance cholangiopancreatography (MRCP) showed pancreatic duct dilation and an unclear image of the head of the pancreas. Read More

Exp Ther Med 2018 Nov 10;16(5):4232-4238. Epub 2018 Sep 10.

Department of General Surgery, Ordos Central Hospital, Ordos, Inner Mongolia 017000, P.R. China.

The present study aimed to investigate early risk factors for hyperlipidemic acute pancreatitis (HLAP) in order to open up novel routes for its prevention and treatment. Demographics, laboratory data obtained within 48 h, enhanced computed tomography (CT) imaging data and the modified CT severity index (MCTSI) for 111 patients with HLAP who were assessed at Ordos Central Hospital (Ordos, China) between January 2015 and October 2017 were retrospectively analyzed. Of these, 17 patients progressed to infectious pancreatic necrosis (IPN) and 14 patients progressed to organ failure (OF), the occurrence of which were the study outcomes. Read More

Pancreas 2018 Nov/Dec;47(10):1193-1199

Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA.

Recurrent acute pancreatitis (RAP) is a complex clinical syndrome with significant morbidity, unpredictable outcomes, and limited treatment options. The National Institute of Diabetes and Digestive and Kidney Disease sponsored a workshop on July 25, 2018, in Pittsburgh, Pennsylvania, to address research gaps impeding development of effective therapies for pancreatitis. The RAP working group identified challenges to clinical progress using existing definitions, risk assessment, diagnostic and severity criteria, disease trajectories, outcomes, and research methods. Read More

Radiology 2019 Jan 16;290(1):207-215. Epub 2018 Oct 16.

From the Department of Radiology and Imaging Sciences (T.T.) and Department of Medicine, Division of Gastroenterology (E.L.F.), Indiana University School of Medicine, 550 N University Blvd, Suite 0663, Indianapolis, Ind 46202; Department of Radiology (Z.K.S.) and Department of Medicine, Division of Gastroenterology, Hepatology & Nutrition (D.L.C.), Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Radiology (N.T., S.K.V.) and Department of Medicine, Division of Gastroenterology and Hepatology (M.T.), Mayo Clinic, Rochester, Minn; Department of Radiology, University of Florida College of Medicine, Gainesville, Fla (J.R.G.); Department of Radiology and Division of Body MRI, Stanford University School of Medicine, Stanford, Calif (S.T.C.); Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, Calif (W.P.); Department of Medicine, Division of Gastroenterology, Hepatology & Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pa (D.Y.); Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pa (A.K.D.).

Chronic pancreatitis is an inflammatory condition of the pancreas with clinical manifestations ranging from abdominal pain, acute pancreatitis, exocrine and/or endocrine dysfunction, and pancreatic cancer. There is a need for longitudinal studies in well-phenotyped patients to ascertain the utility of cross-sectional imaging findings of chronic pancreatitis for diagnosis and assessment of disease severity. CT and MR cholangiopancreatography are the most common cross-sectional imaging studies performed for the evaluation of chronic pancreatitis. Read More

Indian J Radiol Imaging 2018 Jul-Sep;28(3):374-375

Jhalawar Medical College, Rajasthan, India E-mail:

BMJ Case Rep 2018 Oct 12;2018. Epub 2018 Oct 12.

Department of Critical Care Medicine, Mayo Clinic's Campus in Florida, Jacksonville, Florida, USA.

A 63-year-old man was admitted for severe acute pancreatitis. On day 3 of hospitalisation, he developed shortness of breath and acute pulmonary oedema. Echocardiogram revealed global hypokinesis with a left ventricular ejection fraction of 20%, and he was diagnosed with takotsubo cardiomyopathy. Read More

J Surg Case Rep 2018 Oct 5;2018(10):rjy259. Epub 2018 Oct 5.

Centre Hospitalier de l'Université de Montréal (CHUM), Service de chirurgie digestive, 1051 rue Sanguinet, Montréal, Québec, Canada.

An ectopic pancreas, also known as pancreatic rest or heterotopic pancreas, consists of pancreatic tissue found in a location with no continuity with the anatomic pancreas. This lesion can occasionally cause gastrointestinal obstruction, ulceration or become inflamed and cause ectopic pancreatitis. We present the case of a 29-year-old immunocompromised female patient due to a previous kidney transplant. Read More

Trials 2018 Oct 11;19(1):549. Epub 2018 Oct 11.

Department of Gastroenterology, Changhai Hospital, Second Military Medical University/ Naval Medical University, 168 Changhai Road, Shanghai, 200433, China.

Background: Endoscopic ultrasonography (EUS)-guided drainage has become the first-line therapy for late peri-pancreatic fluid collection (PFC). Double pigtail plastic stents (DPPS) and lumen-apposing metal stents (LAMS) are commonly used for PFC drainage. Recently, a multi-institutional consensus on PFC drainage has recommended that LAMS should be the standard care for patients with walled-off necrosis (WON). Read More