985 results match your criteria Acute Pain[Journal]


Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain.

Pain 2019 Jan 3. Epub 2019 Jan 3.

Alan Edwards Centre for Research on Pain, McGill University, Montre[Combining Acute Accent]al, QC, Canada.

Chronic pain is a debilitating and poorly treated condition whose underlying mechanisms are poorly understood. Nerve injury and inflammation cause alterations in gene expression in tissues associated with pain processing, supporting molecular and cellular mechanisms that maintain painful states. However, it is not known whether transcriptome changes can be used to reconstruct a molecular pathophysiology of pain. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001471DOI Listing
January 2019
3 Reads

The serum protease network - one key to understand Complex Regional Pain Syndrome pathophysiology.

Pain 2019 Jan 28. Epub 2019 Jan 28.

Department of Neurology, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.

Complex Regional Pain Syndrome (CRPS) develops after fracture. The acute CRPS phenotype resembles exaggerated inflammation which is explained by local and systemic activation of a pro-inflammatory network including peptides and cytokines. Epidemiologic data suggest that inactivation of the peptidase angiotensin converting enzyme (ACE) in patients treated for hypertension increases the odds to develop CRPS. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001503DOI Listing
January 2019
2 Reads

Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain.

Pain 2018 Dec 3. Epub 2018 Dec 3.

Department of Pharmacology, Arizona Health Sciences Center, University of Arizona, Tucson, AZ, United States.

Chronic pain is associated with neuroplastic changes in the amygdala that may promote hyper-responsiveness to mechanical and thermal stimuli (allodynia and hyperalgesia) and/or enhance emotional and affective consequences of pain. Stress promotes dynorphin-mediated signaling at the kappa opioid receptor (KOR) in the amygdala and mechanical hypersensitivity in rodent models of functional pain. Here, we tested the hypothesis that KOR circuits in the central nucleus of the amygdala (CeA) undergo neuroplasticity in chronic neuropathic pain resulting in increased sensory and affective pain responses. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001458DOI Listing
December 2018

Hedonic drinking engages a supra-spinal inhibition of thermal nociception in adult rats.

Pain 2019 Jan 11. Epub 2019 Jan 11.

Dental Research Institute and Department of Neurobiology and Physiology, School of Dentistry, Seoul National University, Republic of Korea.

The taste of sucrose is commonly used to provide pain relief in newborn humans and is innately analgesic to neonatal rodents. In adulthood, sucrose remains a strong motivator to feed, even in potentially hazardous circumstances (i.e. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001482DOI Listing
January 2019
3 Reads

Intact mast cell content during mild head injury is required for development of latent pain sensitization: implications for mechanisms underlying post-traumatic headache.

Authors:
Dara Bree Dan Levy

Pain 2019 Jan 7. Epub 2019 Jan 7.

Departments of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston , MA 02115.

Post-traumatic headache (PTH) is one of the most common, debilitating and difficult symptoms to manage after a traumatic head injury. While the mechanisms underlying PTH remain elusive, recent studies in rodent models suggest the potential involvement of calcitonin gene-related peptide (CGRP), a mediator of neurogenic inflammation, and the ensuing activation of meningeal mast cells (MCs), pro-algesic resident immune cells that can lead to the activation of the headache pain pathway. Here, we investigated the relative contribution of MCs to the development of PTH-like pain behaviors in a model of mild closed head injury (mCHI) in male rats. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001481DOI Listing
January 2019
2 Reads

The IASP classification of chronic pain for ICD-11: chronic neuropathic pain.

Pain 2019 Jan;160(1):53-59

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

The upcoming 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD) of the World Health Organization (WHO) offers a unique opportunity to improve the representation of painful disorders. For this purpose, the International Association for the Study of Pain (IASP) has convened an interdisciplinary task force of pain specialists. Here, we present the case for a reclassification of nervous system lesions or diseases associated with persistent or recurrent pain for ≥3 months. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310153PMC
January 2019
13 Reads
5.213 Impact Factor

The IASP classification of chronic pain for ICD-11: chronic postsurgical or posttraumatic pain.

Pain 2019 Jan;160(1):45-52

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Germany.

Chronic pain after tissue trauma is frequent and may have a lasting impact on the functioning and quality of life of the affected person. Despite this, chronic postsurgical and posttraumatic pain is underrecognised and, consequently, undertreated. It is not represented in the current International Classification of Diseases (ICD-10). Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001413DOI Listing
January 2019
2 Reads

Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11).

Pain 2019 Jan;160(1):19-27

The Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.

Chronic pain is a major source of suffering. It interferes with daily functioning and often is accompanied by distress. Yet, in the International Classification of Diseases, chronic pain diagnoses are not represented systematically. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001384DOI Listing
January 2019
3 Reads
5.213 Impact Factor

Somatosensory profiles in acute herpes zoster and predictors of postherpetic neuralgia.

Pain 2018 Dec 20. Epub 2018 Dec 20.

Department of Anaesthesiology, Multidisciplinary Pain Centre, University Hospital LMU Munich, Munich, Germany.

This prospective cohort study aimed to characterize the sensory profile during acute herpes zoster (AHZ) and to explore sensory signs as well as physical and psychosocial health as predictors for postherpetic neuralgia (PHN). Results of quantitative sensory testing of 74 patients with AHZ at the affected site and at the distant contralateral control site were compared to a healthy control group. Pain characteristics (Neuropathic Pain and Symptom Inventory and SES), physical functioning, and psychosocial health aspects (Pain Disability Index, SF-36, and STAI) were assessed by questionnaires. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001467DOI Listing
December 2018
11 Reads

Medicine use during acute and chronic post-injury periods in whiplash injured individuals.

Pain 2018 Dec 7. Epub 2018 Dec 7.

Recover Injury Research Centre, The University of Queensland, Australia.

Medicine use as part of multimodal management for whiplash-associated disorders (WAD) is common: neck pain is the cardinal symptom, mental health conditions are common, and some individuals may have neurological signs and symptoms. Almost half of WAD individuals have on-going pain and disability. However, medicine use during acute and chronic recovery periods for WAD management is unknown. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001460DOI Listing
December 2018
4 Reads

Functional brain activity during motor control and pain processing in chronic jaw pain.

Pain 2018 Dec;159(12):2547-2564

Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United States.

Changes in brain function in chronic pain have been studied using paradigms that deliver acute pain-eliciting stimuli or assess the brain at rest. Although motor disability accompanies many chronic pain conditions, few studies have directly assessed brain activity during motor function in individuals with chronic pain. Using chronic jaw pain as a model, we assessed brain activity during a precisely controlled grip force task and during a precisely controlled pain-eliciting stimulus on the forearm. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001366DOI Listing
December 2018
12 Reads

Children and adolescents with sickle cell disease have worse cold and mechanical hypersensitivity during acute painful events.

Pain 2019 Feb;160(2):407-416

Section of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, United States.

Sickle cell disease (SCD) pain associates with cold temperature and touch. Patients and murine models with SCD have baseline thermal and mechanical pain. In SCD mice, the baseline hypersensitivity is exacerbated by experimental vaso-occlusive crises. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001407DOI Listing
February 2019
1 Read

Contribution of dorsal root ganglion octamer transcription factor 1 to neuropathic pain after peripheral nerve injury.

Pain 2019 Feb;160(2):375-384

Department of Anesthesiology, New Jersey Medical School, Rutgers the State University of New Jersey, Newark, NJ, United States.

Neuropathic pain genesis is related to gene alterations in the dorsal root ganglion (DRG) after peripheral nerve injury. Transcription factors control gene expression. In this study, we investigated whether octamer transcription factor 1 (OCT1), a transcription factor, contributed to neuropathic pain caused by chronic constriction injury (CCI) of the sciatic nerve. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344274PMC
February 2019
5 Reads
5.210 Impact Factor

Recommendations for selection of self-report pain intensity measures in children and adolescents: a systematic review and quality assessment of measurement properties.

Pain 2019 Jan;160(1):5-18

Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada.

In 2006, PAIN published a systematic review of the measurement properties of self-report pain intensity measures in children and adolescents (Stinson JN, Kavanagh T, Yamada J, Gill N, Stevens B. Systematic review of the psychometric properties, interpretability and feasibility of self-report pain intensity measures for use in clinical trials in children and adolescents. PAIN 2006;125:143-57). Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001377DOI Listing
January 2019
14 Reads

Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.

Pain 2019 Jan;160(1):136-150

Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, Montreal, QC, Canada.

Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of cannabis that interacts with the serotonin (5-HT)1A receptor, may possess analgesic and anxiolytic effects. However, its effects on 5-HT neuronal activity, as well as its impact on models of neuropathic pain are unknown. First, using in vivo single-unit extracellular recordings in rats, we demonstrated that acute intravenous (i. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319597PMC
January 2019
29 Reads
5.213 Impact Factor

Morphine effects within the rodent anterior cingulate cortex and rostral ventromedial medulla reveal separable modulation of affective and sensory qualities of acute or chronic pain.

Pain 2018 Dec;159(12):2512-2521

Department of Pharmacology, University of Arizona, Tucson, AZ, United States.

Modulation of pain may result from engagement of opioid receptors in multiple brain regions. Whether sensory and affective qualities of pain are differentially affected by brain opioid receptor circuits remains unclear. We previously reported that opioid actions within the rostral anterior cingulate cortex (ACC) produce selective modulation of affective qualities of neuropathic pain in rodents, but whether such effects may occur in other areas of the ACC is not known. Read More

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http://Insights.ovid.com/crossref?an=00006396-900000000-9888
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http://dx.doi.org/10.1097/j.pain.0000000000001355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320264PMC
December 2018
19 Reads

Isolated nociceptors reveal multiple specializations for generating irregular ongoing activity associated with ongoing pain.

Pain 2018 Nov;159(11):2347-2362

Department of Integrative Biology and Pharmacology, McGovern Medical School at UTHealth, Houston, TX, United States.

Ongoing pain has been linked to ongoing activity (OA) in human C-fiber nociceptors, but rodent models of pain-related OA have concentrated on allodynia rather than ongoing pain, and on OA generated in non-nociceptive Aβ fibers rather than C-fiber nociceptors. Little is known about how ongoing pain or nociceptor OA is generated. To define neurophysiological alterations underlying nociceptor OA, we have used isolated dorsal root ganglion neurons that continue to generate OA after removal from animals displaying ongoing pain. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193853PMC
November 2018
8 Reads

Complex regional pain syndrome: intradermal injection of phenylephrine evokes pain and hyperalgesia in a subgroup of patients with upregulated α1-adrenoceptors on dermal nerves.

Pain 2018 Nov;159(11):2296-2305

Danish Pain Research Center, Aarhus University Hospital, Aarhus, Denmark.

The aim of this study was to determine whether upregulated cutaneous expression of α1-adrenoceptors (α1-AR) is a source of pain in patients with complex regional pain syndrome (CRPS). Immunohistochemistry was used to identify α1-AR on nerve fibres and other targets in the affected and contralateral skin of 90 patients, and in skin samples from 38 pain-free controls. The distribution of α1-AR was compared between patients and controls, and among subgroups of patients defined by CRPS duration, limb temperature asymmetry, and diagnostic subtype (CRPS I vs CRPS II). Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001335DOI Listing
November 2018
26 Reads

Estimating relative efficacy in acute postoperative pain: network meta-analysis is consistent with indirect comparison to placebo alone.

Pain 2018 Nov;159(11):2234-2244

Centre for Pain Research, University of Bath, Bath, United Kingdom.

Network meta-analysis uses direct comparisons of interventions within randomized controlled trials and indirect comparisons across them. Network meta-analysis uses more data than a series of direct comparisons with placebo, and theoretically should produce more reliable results. We used a Cochrane overview review of acute postoperative pain trials and other systematic reviews to provide data to test this hypothesis. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203421PMC
November 2018
8 Reads

Efficacy of hypnosis on pain, wound-healing, anxiety, and stress in children with acute burn injuries: a randomized controlled trial.

Pain 2018 Sep;159(9):1790-1801

Center for Children's Burns and Trauma Research, Level 7, Children's Health Research Center, The University of Queensland, South Brisbane, Queensland, Australia.

No randomized controlled trial has investigated the efficacy of hypnosis for reducing pain and improving wound-healing in children with burns. This randomized controlled trial aimed to investigate whether hypnosis decreases pain, anxiety, and stress and accelerates wound-healing in children undergoing burn wound procedures. Children (4-16 years) with acute burns presenting for their first dressing change were randomly assigned to a Hypnosis Group who received hypnosis plus standard care or a Standard Care Group who received standard pharmacological and nonpharmacological intervention. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001276DOI Listing
September 2018
27 Reads
5.213 Impact Factor

Color-selective photophobia in ictal vs interictal migraineurs and in healthy controls.

Pain 2018 Oct;159(10):2030-2034

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States.

Aversion to light is common among migraineurs undergoing acute attacks. Using psychophysical assessments in patients with episodic migraine, we reported that white, blue, amber, and red lights exacerbate migraine headache in a significantly larger percentage of patients and to a greater extent compared with green light. This study aimed at determining whether these findings are phase-dependent-namely, manifested exclusively during migraine (ictally) but not in its absence (interictally), or condition-dependent-ie, expressed uniquely in migraineurs but not in healthy controls. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347023PMC
October 2018
44 Reads

Why wait to address high-risk cases of acute low back pain? A comparison of stepped, stratified, and matched care.

Pain 2018 Dec;159(12):2437-2441

Division of Occupational and Environmental Medicine, University of Connecticut Health Center, United States.

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http://dx.doi.org/10.1097/j.pain.0000000000001308DOI Listing
December 2018
5 Reads

Patterns of recovery from pain after cesarean delivery.

Pain 2018 Oct;159(10):2088-2096

Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, United States.

We know very little about the change in pain in the first 2 months after surgery. To address this gap, we studied 530 women scheduled for elective cesarean delivery who completed daily pain diaries for 2 months after surgery through text messaging. Over 82% of subjects missed fewer than 10 diary entries and were included in the analysis. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328056PMC
October 2018
4 Reads

Trigeminal ganglion transcriptome analysis in 2 rat models of medication-overuse headache reveals coherent and widespread induction of pronociceptive gene expression patterns.

Pain 2018 Oct;159(10):1980-1988

Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy.

We attempted to gather information on the pathogenesis of medication-overuse headache, as well as on the neurochemical mechanisms through which symptomatic medication overuse concurs to headache chronification. Transcriptional profiles were therefore evaluated as an index of the homeostasis of the trigeminovascular system in the trigeminal ganglion of female rats exposed for 1 month to daily oral doses of eletriptan or indomethacin. We report that both drug treatments change trigeminal ganglion gene expression to a similar extend. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001291DOI Listing
October 2018
5 Reads

Chronic neuropathic pain reduces opioid receptor availability with associated anhedonia in rat.

Pain 2018 Sep;159(9):1856-1866

Division of Intramural Research, National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD, United States.

The opioid system plays a critical role in both the experience and management of pain. Although acute activation of the opioid system can lead to pain relief, the effects of chronic pain on the opioid system remain opaque. Cross-sectional positron emission tomography (PET) studies show reduced availability of brain opioid receptors in patients with chronic pain but are unable to (1) determine whether these changes are due to the chronic pain itself or due to preexisting or medication-induced differences in the endogenous opioid system, and (2) identify the neurobiological substrate of reduced opioid receptor availability. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095806PMC
September 2018
6 Reads

Hemisensory disturbances in patients with complex regional pain syndrome.

Pain 2018 Sep;159(9):1824-1832

Danish Pain Research Center, Aarhus University Hospital, Aarhus, Denmark.

Sensory disturbances often spread beyond the site of injury in complex regional pain syndrome (CRPS) but whether this applies equally to CRPS I and II, or changes across the course of the disease, is unknown. Establishing this is important, because different symptom profiles in CRPS I and II, or in acute vs chronic CRPS, might infer different pathophysiology and treatment approaches. To explore these questions, sensory disturbances were assessed in the limbs and forehead of 71 patients with CRPS I and 33 patients with CRPS II. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001280DOI Listing
September 2018
4 Reads

"From ear to trunk"-magnetic resonance imaging reveals referral of pain.

Pain 2018 Sep;159(9):1900-1903

Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Referred and projecting pain can be observed in acute and chronic pain states. We present the case of a 69-year-old female patient with postherpetic neuralgia in dermatome Th2/3 who reported that touching the ipsilateral earlap (dermatome C2) would enhance pain and dynamic mechanical allodynia in the affected Th2/3-dermatome. The aim was to investigate possible underlying mechanisms of this phenomenon using the capsaicin experimental pain sensitization model, quantitative sensory testing, and functional spinal and supraspinal magnetic resonance imaging. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001279DOI Listing
September 2018
12 Reads

Peripherally restricted cannabinoid 1 receptor agonist as a novel analgesic in cancer-induced bone pain.

Pain 2018 Sep;159(9):1814-1823

Departments of Pharmacology and.

Many malignant cancers, including breast cancer, have a propensity to invade bones, leading to excruciating bone pain. Opioids are the primary analgesics used to alleviate this cancer-induced bone pain (CIBP) but are associated with numerous severe side effects, including enhanced bone degradation, which significantly impairs patients' quality of life. By contrast, agonists activating only peripheral CB1 receptors (CB1Rs) have been shown to effectively alleviate multiple chronic pain conditions with limited side effects, yet no studies have evaluated their role(s) in CIBP. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095738PMC
September 2018
7 Reads

A bifunctional-biased mu-opioid agonist-neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects.

Pain 2018 Sep;159(9):1705-1718

Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.

Opioid analgesics, such as morphine, oxycodone, and fentanyl, are the cornerstones for treating moderate to severe pain. However, on chronic administration, their efficiency is limited by prominent side effects such as analgesic tolerance and dependence liability. Neuropeptide FF (NPFF) and its receptors (NPFF1R and NPFF2R) are recognized as an important pronociceptive system involved in opioid-induced hyperalgesia and analgesic tolerance. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001262DOI Listing
September 2018
10 Reads

Chemokine (c-c motif) receptor 2 mediates mechanical and cold hypersensitivity in sickle cell disease mice.

Pain 2018 Aug;159(8):1652-1663

Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, United States.

Approximately one-third of individuals with sickle cell disease (SCD) develop chronic pain. This debilitating pain is inadequately treated because the underlying mechanisms driving the pain are poorly understood. In addition to persistent pain, patients with SCD are also in a tonically proinflammatory state. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317856PMC
August 2018
5 Reads

Spinal protein kinase C/extracellular signal-regulated kinase signal pathway mediates hyperalgesia priming.

Pain 2018 May;159(5):907-918

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Chronic pain can be initiated by one or more acute stimulations to sensitize neurons into the primed state. In the primed state, the basal nociceptive thresholds of the animal are normal, but, in response to another hyperalgesic stimulus, the animal develops enhanced and prolonged hyperalgesia. The exact mechanism of how primed state is formed is not completely understood. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001162DOI Listing
May 2018
8 Reads

Dyadic analysis of siblings' relationship quality, behavioural responses, and pain experiences during experimental pain.

Pain 2018 Aug;159(8):1569-1579

Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada.

Research on family factors in paediatric pain has primarily focused on parents; the role of siblings has been largely ignored. This study examined whether sibling relationship quality was related to siblings' behaviours during experimental pain, and whether the behaviours of an observing sibling were related to children's pain outcomes. Ninety-two sibling dyads between 8 and 12 years old completed both observational and questionnaire measures of sibling relationship quality. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001244DOI Listing
August 2018
4 Reads

Comparison of the psychometric properties of 3 pain scales used in the pediatric emergency department: Visual Analogue Scale, Faces Pain Scale-Revised, and Colour Analogue Scale.

Pain 2018 Aug;159(8):1508-1517

Women and Children's Health Research Institute, Edmonton, AB, Canada.

Appropriate pain measurement relies on the use of valid, reliable tools. The aim of this study was to determine and compare the psychometric properties of 3 self-reported pain scales commonly used in the pediatric emergency department (ED). The inclusion criteria were children aged 6 to 17 years presenting to the ED with a musculoskeletal injury and self-reported pain scores ≥30 mm on the mechanical Visual Analogue Scale (VAS). Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001236DOI Listing
August 2018
10 Reads

Early workplace dialogue in physiotherapy practice improved work ability at 1-year follow-up-WorkUp, a randomised controlled trial in primary care.

Pain 2018 Aug;159(8):1456-1464

Department of Clinical Sciences Lund, Orthopedics, Lund University, Lund, Sweden.

Workplace involvement in rehabilitation for patients with musculoskeletal pain may improve work ability. Convergence Dialogue Meeting (CDM) is a model aimed at helping the patient, the care giver, and the employer to support work ability and return-to-work. Our aim was to study the effect on work ability when adding a workplace dialogue according to CDM in physiotherapy practice for patients with pain in ordinary primary care. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085128PMC
August 2018
9 Reads

Carbenoxolone as a novel therapy for attenuation of cancer-induced bone pain.

Authors:
Sarah Falk

Pain 2018 Jun;159(6):1127-1136

Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.

Pain is a major complication for patients with cancer significantly compromising their quality of life. Current treatment is far from optimal and particularly bone-related cancer pain poses an increasing clinical and socioeconomical problem. Connexins, key proteins in cell-cell communication, have the potential to affect cancer-induced bone pain at multiple levels, including nociceptive signaling and bone degradation. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001197DOI Listing
June 2018
9 Reads

Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity.

Pain 2018 Jun;159(6):1012-1024

Applied Human Molecular Genetics, Clinical Genetic Clinic, Kennedy Center, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.

Human studies have demonstrated a correlation between noncoding polymorphisms of "the pain protective" haplotype in the GCH1 gene that encodes for GTP cyclohydrolase I (GTPCH1)-which leads to reduced tetrahydrobiopterin (BH4) production in cell systems-and a diminished perception of experimental and clinical pain. Here, we investigate whether heterozygous mutations in the GCH1 gene which lead to a profound BH4 reduction in patients with dopa-responsive dystonia (DRD) have any effect on pain sensitivity. The study includes an investigation of GCH1-associated biomarkers and pain sensitivity in a cohort of 22 patients with DRD and 36 controls. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001175DOI Listing
June 2018
19 Reads
5.213 Impact Factor

Racial differences in presentations and predictors of acute pain after motor vehicle collision.

Pain 2018 Jun;159(6):1056-1063

Anesthesiology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA.

African Americans experience a greater burden of acute pain than non-Hispanic white individuals across of variety of acute medical conditions, but it is unknown whether this is the case after trauma. We evaluated pain, pain-related characteristics (eg, peritraumatic distress), and analgesic treatment in 2 cohorts of individuals (African American [n = 931] and non-Hispanic white [n = 948]) presenting to the emergency department (ED) after a motor vehicle collision. We performed a propensity-matched analysis (n = 796 in each group) to assess racial differences in acute pain in the ED. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001186DOI Listing
June 2018
9 Reads

Psychological factors predict an unfavorable pain trajectory after hysterectomy: a prospective cohort study on chronic postsurgical pain.

Pain 2018 May;159(5):956-967

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.

Chronic postsurgical pain (CPSP) is a well-recognized potential complication with negative personal, social, and health care consequences. However, limited data exist on CPSP and on the course of pain over time after hysterectomy. Using data from a prospective cohort study on a consecutive sample assessed at 4 time points, presurgery (T1), 48 hours (T2), 4 months (T3), and 5 years postsurgery (T4), we sought to examine women's PSP trajectories using assessments of pain at T3 and T4. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001170DOI Listing
May 2018
8 Reads
5.210 Impact Factor

Correlates and importance of neglect-like symptoms in complex regional pain syndrome.

Pain 2018 May;159(5):978-986

Department of Neurology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Neglect-like symptoms (NLS) are frequently observed in complex regional pain syndrome (CRPS). The clinical meaning of NLS, however, is largely unknown. Therefore, this study sets out to assess the importance of NLS for patient outcome and to explore their clinical correlates. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001173DOI Listing
May 2018
12 Reads

Spinal PKC/ERK signal pathway mediates hyperalgesia priming.

Pain 2018 Jan 18. Epub 2018 Jan 18.

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Chronic pain can be initiated by one or more acute stimulations to sensitize neurons into the primed state. In the primed state, the basal nociceptive thresholds of the animal are normal, but in response to another hyperalgesic stimulus, the animal develops enhanced and prolonged hyperalgesia. The exact mechanism of how primed state is formed is not completely understood. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001162DOI Listing
January 2018
10 Reads

Joint nociceptor nerve activity and pain in an animal model of acute gout and its modulation by intra-articular hyaluronan.

Pain 2018 Apr;159(4):739-748

Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, Alicante, Spain.

The mechanisms whereby deposition of monosodium urate (MSU) crystals in gout activates nociceptors to induce joint pain are incompletely understood. We tried to reproduce the signs of painful gouty arthritis, injecting into the knee joint of rats suspensions containing amorphous or triclinic, needle MSU crystals. The magnitude of MSU-induced inflammation and pain behavior signs were correlated with the changes in firing frequency of spontaneous and movement-evoked nerve impulse activity recorded in single knee joint nociceptor saphenous nerve fibers. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895116PMC
April 2018
12 Reads

Pain or nociception? Subjective experience mediates the effects of acute noxious heat on autonomic responses.

Pain 2018 Apr;159(4):699-711

National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD, USA.

Nociception reliably elicits an autonomic nervous system (ANS) response. Because pain and ANS circuitry interact on multiple spinal, subcortical, and cortical levels, it remains unclear whether autonomic responses are simply a reflexive product of noxious stimulation regardless of how stimulation is consciously perceived or whether the experience of pain mediates ANS responses to noxious stimulation. To test these alternative predictions, we examined the relative contribution of noxious stimulation and individual pain experience to ANS responses in healthy volunteers who underwent 1 or 2 pain assessment tasks. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901905PMC
April 2018
13 Reads

Induction of chronic migraine phenotypes in a rat model after environmental irritant exposure.

Pain 2018 Mar;159(3):540-549

Departments of Biochemistry and Molecular Biology.

Air pollution is linked to increased emergency department visits for headache and migraine patients frequently cite chemicals or odors as headache triggers, but the association between air pollutants and headache is not well understood. We previously reported that chronic environmental irritant exposure sensitizes the trigeminovascular system response to nasal administration of environmental irritants. Here, we examine whether chronic environmental irritant exposure induces migraine behavioral phenotypes. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812801PMC
March 2018
20 Reads

Tactile acuity (dys)function in acute nociceptive low back pain: a double-blind experiment.

Pain 2018 Mar;159(3):427-436

Department of Kinesiotherapy and Special Methods in Physiotherapy, The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland.

Research shows that chronic pain is related to cortical alterations that can be reflected in reduced tactile acuity, but whether acute pain perception influences tactile acuity has not been tested. Considering the biological role of nociception, it was hypothesized that nociceptive pain will lead to a rapid improvement in tactile acuity and that this effect is correlated with pain intensity and pain distribution. In this randomised double-blind controlled experiment (trial no. Read More

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http://Insights.ovid.com/crossref?an=00006396-900000000-9910
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http://dx.doi.org/10.1097/j.pain.0000000000001110DOI Listing
March 2018
16 Reads

Clinical trial designs and models for analgesic medications for acute pain in neonates, infants, toddlers, children, and adolescents: ACTTION recommendations.

Pain 2018 02;159(2):193-205

Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.

Clinical trials to test the safety and efficacy of analgesics across all pediatric age cohorts are needed to avoid inappropriate extrapolation of adult data to children. However, the selection of acute pain models and trial design attributes to maximize assay sensitivity, by pediatric age cohort, remains problematic. Acute pain models used for drug treatment trials in adults are not directly applicable to the pediatric age cohorts-neonates, infants, toddlers, children, and adolescents. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949239PMC
February 2018
42 Reads

Nucleus accumbens mediates the pronociceptive effect of sleep deprivation: the role of adenosine A2A and dopamine D2 receptors.

Pain 2018 01;159(1):75-84

Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.

Sleep disorders increase pain sensitivity and the risk of developing painful conditions; however, the underlying mechanisms are poorly understood. It has been suggested that nucleus accumbens (NAc) influences sleep-wake cycle by means of a balance between adenosine activity at A2A receptors and dopamine activity at D2 receptors. Because the NAc also plays an important role in pain modulation, we hypothesized that the NAc and its A2A and D2 receptors mediate the pronociceptive effect of rapid eye movement (REM) sleep deprivation (SD). Read More

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http://Insights.ovid.com/crossref?an=00006396-201801000-0001
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http://dx.doi.org/10.1097/j.pain.0000000000001066DOI Listing
January 2018
10 Reads

Photosensitization of TRPA1 and TRPV1 by 7-dehydrocholesterol: implications for the Smith-Lemli-Opitz syndrome.

Pain 2017 Dec;158(12):2475-2486

aDepartment of Anatomy, Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania bDepartment of Pharmacology and Clinical Pharmacy, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania cInstitute for Physiology and Pathophysiology, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany dInstitute of Physiology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

Loss-of-function mutations in the enzyme 7-dehydrocholesterol reductase are responsible for the Smith-Lemli-Opitz syndrome, in which 7-dehydrocholesterol (7-DHC) levels are markedly increased in the plasma and tissues of patients. This increase in 7-DHC is probably associated with the painful and itchy photosensitivity reported by the majority of patients with Smith-Lemli-Opitz syndrome. To identify the molecular targets involved in the activation and photosensitization of primary afferents by 7-DHC, we focused on TRPA1 and TRPV1, two ion channels expressed in nociceptive nerve endings and previously shown to respond to ultraviolet and visible light under pathophysiological circumstances. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001056DOI Listing
December 2017
20 Reads

Cannabis constituent synergy in a mouse neuropathic pain model.

Pain 2017 Dec;158(12):2452-2460

Pain Management Research Institute, Kolling Institute of Medical Research, Northern Clinical School, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia.

Cannabis and its psychoactive constituent Δ9-tetrahydrocannabinol (THC) have efficacy against neuropathic pain, however, this is hampered by their side effects. It has been suggested that co-administration with another major constituent cannabidiol (CBD) might enhance the analgesic actions of THC and minimise its deleterious side effects. We examined the basis for this phytocannabinoid interaction in a mouse chronic constriction injury (CCI) model of neuropathic pain. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001051DOI Listing
December 2017
8 Reads

Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.

Pain 2017 Dec;158(12):2442-2451

Departments of Pharmacology and Anaesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS, Canada.

Osteoarthritis (OA) is a multifactorial joint disease, which includes joint degeneration, intermittent inflammation, and peripheral neuropathy. Cannabidiol (CBD) is a noneuphoria producing constituent of cannabis that has the potential to relieve pain. The aim of this study was to determine whether CBD is anti-nociceptive in OA, and whether inhibition of inflammation by CBD could prevent the development of OA pain and joint neuropathy. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690292PMC
December 2017
7 Reads

Brain processing of the temporal dimension of acute pain in short-term memory.

Pain 2017 Oct;158(10):2001-2011

aDepartment of Neuroscience, Université de Montréal, Montréal, QC, CanadabCentre de recherche de l'Institut universitaire de gériatrie de Montréal, Université de Montréal, Montréal, QC, CanadacDepartment of psychology, McGill University, Montreal, QC, CanadadDepartment of Stomatology, Université de Montréal, Montréal, QC, CanadaeÉcole Polytechnique de Montréal, Montréal, QC, CanadafÉcole de psychologie, Université Laval, Quebec City, QC, CanadagGroupe de recherche sur le système nerveux central (GRSNC), and Centre de recherche en neuropsychologie et cognition (CERNEC), Université de Montréal, Montréal, QC, Canada.

The dynamics of noxious sensation shapes pain perception, yet the memory of the temporal dimension of pain remains almost completely unexplored. Here, brain activity during the memory of pain duration was contrasted with that associated with the memory of pain intensity using functional magnetic resonance imaging and a delayed reproduction task. Participants encoded, maintained during a short delay, and reproduced (1) the "duration" of pain (ie, onset-to-offset), (2) the "dynamics" of pain (ie, evolution of pain over time), or (3) the intensity of pain (ie, control with no explicit temporal processing required). Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001003DOI Listing
October 2017
12 Reads