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    Color-Selective Photophobia in Ictal vs. Interictal Migraineurs and in Healthy Controls.
    Pain 2018 Jun 12. Epub 2018 Jun 12.
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston MA 02115.
    Aversion to light is common among migraineurs undergoing acute attacks. Using psychophysical assessments in episodic migraine patients, we reported that white, blue, amber and red lights exacerbate migraine headache in a significantly larger percentage of patients and to a greater extent compared to green light. This study aimed at determining whether these findings are phase-dependent - namely, manifested exclusively during migraine (ictally) but not in its absence (interictally), or condition-dependent - i. Read More

    Patterns of Recovery from Pain after Cesarean Delivery.
    Pain 2018 Jun 13. Epub 2018 Jun 13.
    Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC.
    We know very little about the change in pain in the first 2 months after surgery. To address this gap, we studied 530 women scheduled for elective cesarean delivery who completed daily pain diaries for two months after surgery via text messaging. Over 82% of subjects missed fewer than 10 diary entries and were included in the analysis. Read More

    Trigeminal Ganglion Transcriptome Analysis in Two Rat Models of Medication-Overuse Headache Reveals Coherent and Widespread Induction of Pronociceptive Gene Expression Patterns.
    Pain 2018 May 23. Epub 2018 May 23.
    Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Italy.
    We attempted to gather information on the pathogenesis of medication-overuse headache (MOH), as well as on the neurochemical mechanisms through which symptomatic medication overuse concurs to headache chronification. Transcriptional profiles were therefore evaluated as an index of the homeostasis of the trigeminovascular system in the trigeminal ganglion of female rats exposed for 1 month to daily oral doses of eletriptan or indomethacin. We report that both drug treatments change trigeminal ganglion gene expression to a similar extend. Read More

    Chronic neuropathic pain reduces opioid receptor availability with associated anhedonia in rat.
    Pain 2018 May 22. Epub 2018 May 22.
    Division of Intramural Research, National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, Maryland.
    The opioid system plays a critical role in both the experience and management of pain. While acute activation of the opioid system can lead to pain relief, the effects of chronic pain on the opioid system remain opaque. Cross-sectional positron emission tomography (PET) studies show reduced availability of brain opioid receptors in chronic pain patients, but are unable to (i) determine if these changes are due to the chronic pain itself or to pre-existing or medication-induced differences in the endogenous opioid system, and (ii) identify the neurobiological substrate of reduced opioid receptor availability. Read More

    Hemi-sensory disturbances in patients with complex regional pain syndrome.
    Pain 2018 May 21. Epub 2018 May 21.
    Danish Pain Research Center, Aarhus University Hospital, Aarhus, Denmark.
    Sensory disturbances often spread beyond the site of injury in complex regional pain syndrome (CRPS) but whether this applies equally to CRPS I and II, or changes across the course of the disease, is unknown. Establishing this is important, because different symptom profiles in CRPS I and II, or in acute versus chronic CRPS, might infer different pathophysiology and treatment approaches. To explore these questions, sensory disturbances were assessed in the limbs and forehead of 71 patients with CRPS I and 33 patients with CRPS II. Read More

    "From ear to trunk"-magnetic resonance imaging reveals referral of pain.
    Pain 2018 May 16. Epub 2018 May 16.
    Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
    Referred and projecting pain can be observed in acute and chronic pain states. We present the case of a 69-year-old female patient with postherpetic neuralgia in dermatome Th2/3 who reported that touching the ipsilateral earlap (dermatome C2) would enhance pain and dynamic mechanical allodynia in the affected Th2/3-dermatome. The aim was to investigate possible underlying mechanisms of this phenomenon using the capsaicin experimental pain sensitization model, quantitative sensory testing, and functional spinal and supraspinal magnetic resonance imaging. Read More

    Peripherally restricted cannabinoid 1 receptor agonist as a novel analgesic in cancer-induced bone pain.
    Pain 2018 May 16. Epub 2018 May 16.
    Departments of Pharmacology and.
    Many malignant cancers, including breast cancer, have a propensity to invade bones, leading to excruciating bone pain. Opioids are the primary analgesics used to alleviate this cancer-induced bone pain (CIBP) but are associated with numerous severe side effects, including enhanced bone degradation, which significantly impairs patients' quality of life. By contrast, agonists activating only peripheral CB1 receptors (CB1Rs) have been shown to effectively alleviate multiple chronic pain conditions with limited side effects, yet no studies have evaluated their role(s) in CIBP. Read More

    A bifunctional-biased mu-opioid agonist-neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects.
    Pain 2018 Apr 26. Epub 2018 Apr 26.
    Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.
    Opioid analgesics, such as morphine, oxycodone, and fentanyl, are the cornerstones for treating moderate to severe pain. However, on chronic administration, their efficiency is limited by prominent side effects such as analgesic tolerance and dependence liability. Neuropeptide FF (NPFF) and its receptors (NPFF1R and NPFF2R) are recognized as an important pronociceptive system involved in opioid-induced hyperalgesia and analgesic tolerance. Read More

    Chemokine (c-c motif) receptor 2 mediates mechanical and cold hypersensitivity in sickle cell disease mice.
    Pain 2018 Apr 23. Epub 2018 Apr 23.
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
    Approximately one third of individuals with sickle cell disease (SCD) develop chronic pain. This debilitating pain is inadequately treated because the underlying mechanisms driving the pain are poorly understood. In addition to persistent pain, SCD patients are also in a tonically pro-inflammatory state. Read More

    Spinal protein kinase C/extracellular signal-regulated kinase signal pathway mediates hyperalgesia priming.
    Pain 2018 May;159(5):907-918
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
    Chronic pain can be initiated by one or more acute stimulations to sensitize neurons into the primed state. In the primed state, the basal nociceptive thresholds of the animal are normal, but, in response to another hyperalgesic stimulus, the animal develops enhanced and prolonged hyperalgesia. The exact mechanism of how primed state is formed is not completely understood. Read More

    Dyadic analysis of siblings' relationship quality, behavioural responses, and pain experiences during experimental pain.
    Pain 2018 May 31. Epub 2018 May 31.
    Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada.
    Research on family factors in paediatric pain has primarily focused on parents; the role of siblings has been largely ignored. This study examined whether sibling relationship quality was related to siblings' behaviours during experimental pain, and whether the behaviours of an observing sibling were related to children's pain outcomes. Ninety-two sibling dyads between 8 and 12 years old completed both observational and questionnaire measures of sibling relationship quality. Read More

    Comparison of the psychometric properties of 3 pain scales used in the pediatric emergency department: Visual Analogue Scale, Faces Pain Scale-Revised, and Colour Analogue Scale.
    Pain 2018 Mar 30. Epub 2018 Mar 30.
    Women and Children's Health Research Institute, Edmonton, AB, Canada.
    Appropriate pain measurement relies on the use of valid, reliable tools. The aim of this study was to determine and compare the psychometric properties of 3 self-reported pain scales commonly used in the pediatric emergency department (ED). The inclusion criteria were children aged 6 to 17 years presenting to the ED with a musculoskeletal injury and self-reported pain scores ≥30 mm on the mechanical Visual Analogue Scale (VAS). Read More

    Early workplace dialogue in physiotherapy practice improved work ability at 1-year follow-up-WorkUp, a randomised controlled trial in primary care.
    Pain 2018 Mar 15. Epub 2018 Mar 15.
    Department of Clinical Sciences Lund, Orthopedics, Lund University, Lund, Sweden.
    Workplace involvement in rehabilitation for patients with musculoskeletal pain may improve work ability. Convergence Dialogue Meeting (CDM) is a model aimed at helping the patient, the care giver, and the employer to support work ability and return-to-work. Our aim was to study the effect on work ability when adding a workplace dialogue according to CDM in physiotherapy practice for patients with pain in ordinary primary care. Read More

    Carbenoxolone as a novel therapy for attenuation of cancer-induced bone pain.
    Pain 2018 Jun;159(6):1127-1136
    Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
    Pain is a major complication for patients with cancer significantly compromising their quality of life. Current treatment is far from optimal and particularly bone-related cancer pain poses an increasing clinical and socioeconomical problem. Connexins, key proteins in cell-cell communication, have the potential to affect cancer-induced bone pain at multiple levels, including nociceptive signaling and bone degradation. Read More

    Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity.
    Pain 2018 Jun;159(6):1012-1024
    Applied Human Molecular Genetics, Clinical Genetic Clinic, Kennedy Center, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
    Human studies have demonstrated a correlation between noncoding polymorphisms of "the pain protective" haplotype in the GCH1 gene that encodes for GTP cyclohydrolase I (GTPCH1)-which leads to reduced tetrahydrobiopterin (BH4) production in cell systems-and a diminished perception of experimental and clinical pain. Here, we investigate whether heterozygous mutations in the GCH1 gene which lead to a profound BH4 reduction in patients with dopa-responsive dystonia (DRD) have any effect on pain sensitivity. The study includes an investigation of GCH1-associated biomarkers and pain sensitivity in a cohort of 22 patients with DRD and 36 controls. Read More

    Racial differences in presentations and predictors of acute pain after motor vehicle collision.
    Pain 2018 Jun;159(6):1056-1063
    Anesthesiology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA.
    African Americans experience a greater burden of acute pain than non-Hispanic white individuals across of variety of acute medical conditions, but it is unknown whether this is the case after trauma. We evaluated pain, pain-related characteristics (eg, peritraumatic distress), and analgesic treatment in 2 cohorts of individuals (African American [n = 931] and non-Hispanic white [n = 948]) presenting to the emergency department (ED) after a motor vehicle collision. We performed a propensity-matched analysis (n = 796 in each group) to assess racial differences in acute pain in the ED. Read More

    Psychological factors predict an unfavorable pain trajectory after hysterectomy: a prospective cohort study on chronic postsurgical pain.
    Pain 2018 May;159(5):956-967
    Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
    Chronic postsurgical pain (CPSP) is a well-recognized potential complication with negative personal, social, and health care consequences. However, limited data exist on CPSP and on the course of pain over time after hysterectomy. Using data from a prospective cohort study on a consecutive sample assessed at 4 time points, presurgery (T1), 48 hours (T2), 4 months (T3), and 5 years postsurgery (T4), we sought to examine women's PSP trajectories using assessments of pain at T3 and T4. Read More

    Correlates and importance of neglect-like symptoms in complex regional pain syndrome.
    Pain 2018 May;159(5):978-986
    Department of Neurology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
    Neglect-like symptoms (NLS) are frequently observed in complex regional pain syndrome (CRPS). The clinical meaning of NLS, however, is largely unknown. Therefore, this study sets out to assess the importance of NLS for patient outcome and to explore their clinical correlates. Read More

    Spinal PKC/ERK signal pathway mediates hyperalgesia priming.
    Pain 2018 Jan 18. Epub 2018 Jan 18.
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
    Chronic pain can be initiated by one or more acute stimulations to sensitize neurons into the primed state. In the primed state, the basal nociceptive thresholds of the animal are normal, but in response to another hyperalgesic stimulus, the animal develops enhanced and prolonged hyperalgesia. The exact mechanism of how primed state is formed is not completely understood. Read More

    Joint nociceptor nerve activity and pain in an animal model of acute gout and its modulation by intra-articular hyaluronan.
    Pain 2018 Apr;159(4):739-748
    Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, Alicante, Spain.
    The mechanisms whereby deposition of monosodium urate (MSU) crystals in gout activates nociceptors to induce joint pain are incompletely understood. We tried to reproduce the signs of painful gouty arthritis, injecting into the knee joint of rats suspensions containing amorphous or triclinic, needle MSU crystals. The magnitude of MSU-induced inflammation and pain behavior signs were correlated with the changes in firing frequency of spontaneous and movement-evoked nerve impulse activity recorded in single knee joint nociceptor saphenous nerve fibers. Read More

    Pain or nociception? Subjective experience mediates the effects of acute noxious heat on autonomic responses.
    Pain 2018 Apr;159(4):699-711
    National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD, USA.
    Nociception reliably elicits an autonomic nervous system (ANS) response. Because pain and ANS circuitry interact on multiple spinal, subcortical, and cortical levels, it remains unclear whether autonomic responses are simply a reflexive product of noxious stimulation regardless of how stimulation is consciously perceived or whether the experience of pain mediates ANS responses to noxious stimulation. To test these alternative predictions, we examined the relative contribution of noxious stimulation and individual pain experience to ANS responses in healthy volunteers who underwent 1 or 2 pain assessment tasks. Read More

    Induction of chronic migraine phenotypes in a rat model after environmental irritant exposure.
    Pain 2018 Mar;159(3):540-549
    Departments of Biochemistry and Molecular Biology.
    Air pollution is linked to increased emergency department visits for headache and migraine patients frequently cite chemicals or odors as headache triggers, but the association between air pollutants and headache is not well understood. We previously reported that chronic environmental irritant exposure sensitizes the trigeminovascular system response to nasal administration of environmental irritants. Here, we examine whether chronic environmental irritant exposure induces migraine behavioral phenotypes. Read More

    Tactile acuity (dys)function in acute nociceptive low back pain: a double-blind experiment.
    Pain 2018 Mar;159(3):427-436
    Department of Kinesiotherapy and Special Methods in Physiotherapy, The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland.
    Research shows that chronic pain is related to cortical alterations that can be reflected in reduced tactile acuity, but whether acute pain perception influences tactile acuity has not been tested. Considering the biological role of nociception, it was hypothesized that nociceptive pain will lead to a rapid improvement in tactile acuity and that this effect is correlated with pain intensity and pain distribution. In this randomised double-blind controlled experiment (trial no. Read More

    Clinical trial designs and models for analgesic medications for acute pain in neonates, infants, toddlers, children, and adolescents: ACTTION recommendations.
    Pain 2017 Nov 13. Epub 2017 Nov 13.
    aUniversity of Washington, Seattle, WA, USA bSeattle Children's Hospital, Seattle, WA, USA cCollegium Pharmaceutical, Inc., Canton, MA, USA dHospital for Sick Children, Toronto, ON, Canada eChildren's Hospital of Wisconsin, Milwaukee, WI, USA fPfizer Consumer Healthcare, New York, NY, USA gBoston Children's Hospital, Boston, MA, USA hStanford University School of Medicine, Stanford, CA, USA iStanford Children's Health, Palo alto, CA, USA jJohns Hopkins University Hospital, Baltimore, MA, USA kEmory University, Atlanta, GA USA lUniversity of Rochester, Rochester, NY, USA mQueen's University, Kingston, ON, Canada nChildren's Hospital of Philadelphia, Philadelphia, PA, USA oYale School of Public Health, New Haven, CT, USA.
    Clinical trials to test the safety and efficacy of analgesics across all pediatric age cohorts are needed to avoid inappropriate extrapolation of adult data to children. However, the selection of acute pain models and trial design attributes to maximize assay sensitivity, by pediatric age cohort, remains problematic. Acute pain models used for drug treatment trials in adults are not directly applicable to the pediatric age cohorts - neonates, infants, toddlers, children, and adolescents. Read More

    Nucleus accumbens mediates the pronociceptive effect of sleep deprivation: the role of adenosine A2A and dopamine D2 receptors.
    Pain 2017 Sep 25. Epub 2017 Sep 25.
    Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.
    Sleep disorders increase pain sensitivity and the risk of developing painful conditions; however, the underlying mechanisms are poorly understood. It has been suggested that nucleus accumbens (NAc) influences sleep-wake cycle by means of a balance between adenosine activity at A2A receptors and dopamine activity at D2 receptors. Because the NAc also plays an important role in pain modulation, we hypothesized that the NAc and its A2A and D2 receptors mediate the pronociceptive effect of rapid eye movement (REM) sleep deprivation (SD). Read More

    Photosensitization of TRPA1 and TRPV1 by 7-dehydrocholesterol: implications for the Smith-Lemli-Opitz syndrome.
    Pain 2017 Dec;158(12):2475-2486
    aDepartment of Anatomy, Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania bDepartment of Pharmacology and Clinical Pharmacy, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania cInstitute for Physiology and Pathophysiology, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany dInstitute of Physiology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
    Loss-of-function mutations in the enzyme 7-dehydrocholesterol reductase are responsible for the Smith-Lemli-Opitz syndrome, in which 7-dehydrocholesterol (7-DHC) levels are markedly increased in the plasma and tissues of patients. This increase in 7-DHC is probably associated with the painful and itchy photosensitivity reported by the majority of patients with Smith-Lemli-Opitz syndrome. To identify the molecular targets involved in the activation and photosensitization of primary afferents by 7-DHC, we focused on TRPA1 and TRPV1, two ion channels expressed in nociceptive nerve endings and previously shown to respond to ultraviolet and visible light under pathophysiological circumstances. Read More

    Cannabis constituent synergy in a mouse neuropathic pain model.
    Pain 2017 Dec;158(12):2452-2460
    Pain Management Research Institute, Kolling Institute of Medical Research, Northern Clinical School, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia.
    Cannabis and its psychoactive constituent Δ9-tetrahydrocannabinol (THC) have efficacy against neuropathic pain, however, this is hampered by their side effects. It has been suggested that co-administration with another major constituent cannabidiol (CBD) might enhance the analgesic actions of THC and minimise its deleterious side effects. We examined the basis for this phytocannabinoid interaction in a mouse chronic constriction injury (CCI) model of neuropathic pain. Read More

    Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.
    Pain 2017 Dec;158(12):2442-2451
    Departments of Pharmacology and Anaesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS, Canada.
    Osteoarthritis (OA) is a multifactorial joint disease, which includes joint degeneration, intermittent inflammation, and peripheral neuropathy. Cannabidiol (CBD) is a noneuphoria producing constituent of cannabis that has the potential to relieve pain. The aim of this study was to determine whether CBD is anti-nociceptive in OA, and whether inhibition of inflammation by CBD could prevent the development of OA pain and joint neuropathy. Read More

    Brain processing of the temporal dimension of acute pain in short-term memory.
    Pain 2017 Oct;158(10):2001-2011
    aDepartment of Neuroscience, Université de Montréal, Montréal, QC, CanadabCentre de recherche de l'Institut universitaire de gériatrie de Montréal, Université de Montréal, Montréal, QC, CanadacDepartment of psychology, McGill University, Montreal, QC, CanadadDepartment of Stomatology, Université de Montréal, Montréal, QC, CanadaeÉcole Polytechnique de Montréal, Montréal, QC, CanadafÉcole de psychologie, Université Laval, Quebec City, QC, CanadagGroupe de recherche sur le système nerveux central (GRSNC), and Centre de recherche en neuropsychologie et cognition (CERNEC), Université de Montréal, Montréal, QC, Canada.
    The dynamics of noxious sensation shapes pain perception, yet the memory of the temporal dimension of pain remains almost completely unexplored. Here, brain activity during the memory of pain duration was contrasted with that associated with the memory of pain intensity using functional magnetic resonance imaging and a delayed reproduction task. Participants encoded, maintained during a short delay, and reproduced (1) the "duration" of pain (ie, onset-to-offset), (2) the "dynamics" of pain (ie, evolution of pain over time), or (3) the intensity of pain (ie, control with no explicit temporal processing required). Read More

    Pain and itch outcome trajectories differ among European American and African American survivors of major thermal burn injury.
    Pain 2017 Nov;158(11):2268-2276
    aInstitute for Trauma Recovery, University of North Carolina, Chapel Hill, NC, USA bDepartment of Anesthesiology, University of North Carolina, Chapel Hill, NC, USA cThe Burn Center, Department of Surgery, MedStar Washington Hospital Center, Washington, DC, USA Departments of dMedicine and eBiostatistics, University of North Carolina, Chapel Hill, NC, USA fJaycee Burn Center, University of North Carolina, Chapel Hill, NC, USA gDepartment of Surgery, University of South Florida, Tampa, FL, USA hDepartment of Emergency Medicine, University of North Carolina, Chapel Hill, NC, USA.
    More than half of individuals experiencing major thermal burn injury (MThBI) receive an autologous skin graft (autograft), in which skin is removed from a healthy "donor" site and transplanted to the burn site. Persistent pain and itch at the graft site are major causes of suffering and disability in MThBI survivors. African Americans have a higher risk of MThBI, and in other clinical settings African Americans experience a greater burden of pain and itch relative to European Americans. Read More

    Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development.
    Pain 2017 Nov;158(11):2222-2232
    aSchool of Life Sciences, The University of Nottingham, Nottingham, United Kingdom. Kwok now with the Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada bCentre for Analytical Bioscience, School of Pharmacy, The University of Nottingham, Nottingham, United Kingdom cArthritis Research UK Pain Centre, Nottingham, United Kingdom.
    Significant age- and experience-dependent remodelling of spinal and supraspinal neural networks occur, resulting in altered pain responses in early life. In adults, endogenous opioid peptide and endocannabinoid (ECs) pain control systems exist which modify pain responses, but the role they play in acute responses to pain and postnatal neurodevelopment is unknown. Here, we have studied the changing role of the ECs in the brainstem nuclei essential for the control of nociception from birth to adulthood in both rats and humans. Read More

    Spinal microglia are required for long-term maintenance of neuropathic pain.
    Pain 2017 Sep;158(9):1792-1801
    aThe Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada bDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada cFaculty of Dentistry, McGill University, Montreal, QC, Canada dInstitut universitaire en santé mentale de Québec, QC, Canada eDepartment of Psychiatry and Neuroscience, Université Laval, Québec, QC, Canada.
    While spinal microglia play a role in early stages of neuropathic pain etiology, whether they are useful targets to reverse chronic pain at late stages remains unknown. Here, we show that microglia activation in the spinal cord persists for >3 months following nerve injury in rodents, beyond involvement of proinflammatory cytokine and chemokine signalling. In this chronic phase, selective depletion of spinal microglia in male rats with the targeted immunotoxin Mac1-saporin and blockade of brain-derived neurotrophic factor-TrkB signalling with intrathecal TrkB Fc chimera, but not cytokine inhibition, almost completely reversed pain hypersensitivity. Read More

    Early life vincristine exposure evokes mechanical pain hypersensitivity in the developing rat.
    Pain 2017 Sep;158(9):1647-1655
    aPain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA bDepartments of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
    Vincristine (VNC) is commonly used to treat pediatric cancers, including the most prevalent childhood malignancy, acute lymphoblastic leukemia. Although clinical evidence suggests that VNC causes peripheral neuropathy in children, the degree to which pediatric chemotherapeutic regimens influence pain sensitivity throughout life remains unclear, in part because of the lack of an established animal model of chemotherapy-induced neuropathic pain during early life. Therefore, this study investigated the effects of VNC exposure between postnatal days (P) 11 and 21 on mechanical and thermal pain sensitivity in the developing rat. Read More

    Propranolol treatment prevents chronic central sensitization induced by repeated dural stimulation.
    Pain 2017 Oct;158(10):2025-2034
    aUniversité Clermont AuvergnebInserm, Neuro-Dol, Clermont-Ferrand, FrancecCHU, Clermont-Ferrand, France.
    Migraine is currently conceptualized as a chronic disease with episodic manifestations. In some patients, migraine attack frequency increases, leading to chronic migraine. Daily preventive therapy is initiated to decrease attack frequency. Read More

    Dose-response study of topical allyl isothiocyanate (mustard oil) as a human surrogate model of pain, hyperalgesia, and neurogenic inflammation.
    Pain 2017 Sep;158(9):1723-1732
    Laboratory of Experimental Cutaneous Pain Research, SMI, Department of Health Science and Technology, School of Medicine, Aalborg University, Aalborg, Denmark.
    Despite being a ubiquitous animal pain model, the natural TRPA1-agonist allyl isothiocyanate (AITC, also known as "mustard oil") has only been sparsely investigated as a potential human surrogate model of pain, sensitization, and neurogenic inflammation. Its dose-response as an algogenic, sensitizing irritant remains to be elucidated in human skin. Three concentrations of AITC (10%, 50%, and 90%) and vehicle (paraffin) were applied for 5 minutes to 3 × 3 cm areas on the volar forearms in 14 healthy volunteers, and evoked pain intensity (visual analog scale 0-100 mm) and pain quality were assessed. Read More

    Placebo effects of a sham opioid solution: a randomized controlled study in patients with chronic low back pain.
    Pain 2017 Oct;158(10):1893-1902
    aDepartment of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanybDepartment of Spinal Surgery, Schön Klink Hamburg Eilbek, Hamburg, GermanycDepartment of Orthopedics, University Medical Center Hamburg-Eppendorf, Hamburg, GermanydDepartment of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, GermanyeDepartment of Psychology, University of Mannheim, Mannheim, Germany.
    This study tested the experimental placebo effect in a group of chronic pain patients. Forty-eight patients having chronic back pain participated in a randomized clinical trial that tested the efficacy of a sham opioid solution (NaCl) compared with an alleged neutral, completely inactive solution (NaCl). We shaped the placebo effect by 2 interventions: verbal instruction and conditioning. Read More

    Child and parent pain catastrophizing and pain from presurgery to 6 weeks postsurgery: examination of cross-sectional and longitudinal actor-partner effects.
    Pain 2017 Oct;158(10):1886-1892
    aLawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, CanadabChild Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, CanadacDepartment of Anesthesia, Pain, and Perioperative Medicine, Dalhousie University, Halifax, NS, CanadadCentre for Pediatric Pain Research, IWK Health Centre, Halifax, NS, CanadaeDepartment of Surgery, Dalhousie University, Halifax, NS, Canada.
    Child and parent pain catastrophizing are reported preoperative risk factors for children's acute and persistent postsurgical pain. This study examined dyadic relations between child and parent pain catastrophizing and child and parent ratings of child pain prior to (M = 4.01 days; "baseline") and following surgery (M = 6. Read More

    Mechanisms of distraction in acute pain perception and modulation.
    Pain 2017 06;158(6):1012-1013
    aLawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada, bChild Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada, cDepartment of Psychology and Neuroscience, Dalhousie University, dCentre for Pediatric Pain Research, IWK Health Centre, eDepartment of Pediatrics, IWK Health Centre, Dalhousie University, fThe Mayday Fund.

    Effects of acute psychological stress on placebo and nocebo responses in a clinically relevant model of visceroception.
    Pain 2017 Aug;158(8):1489-1498
    aInstitute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, Essen, GermanybDepartment of Internal Medicine VI, University Hospital Tuebingen, Tuebingen, Germany.
    There is evidence to suggest a role of emotions in placebo and nocebo effects, but whether acute psychological stress changes the magnitude of placebo or nocebo responses has not been tested. In a clinically relevant model of visceroception, we assessed effects of acute psychological stress on changes in urgency and pain in response to positive or negative treatment suggestions. In 120 healthy volunteers, perceived urge-to-defecate and pain in response to individually calibrated rectal distensions were measured with visual analogue scales during a BASELINE. Read More

    Greater fear of visceral pain contributes to differences between visceral and somatic pain in healthy women.
    Pain 2017 Aug;158(8):1599-1608
    aInstitute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Essen, GermanybClinic for Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, GermanycInstitute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
    This functional magnetic resonance imaging study addressed similarities and differences in behavioral and neural responses to experimental visceral compared with somatic pain stimuli and explored the contribution of fear of pain to differences between pain modalities. In N = 22 healthy women, we assessed blood oxygen level-dependent responses to rectal distensions and cutaneous heat stimuli matched for perceived pain intensity. Fear of pain and pain unpleasantness were assessed before and after scanning. Read More

    Neuropathic pain after chronic nerve constriction may not correlate with chloride dysregulation in mouse trigeminal nucleus caudalis neurons.
    Pain 2017 Jul;158(7):1366-1372
    aDepartment of Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA bProgram in Neuroscience, University of Maryland, Baltimore, MD, USA cDepartment of Endodontics, Prosthodontics, and Operative Surgery, Baltimore College of Dentistry, Baltimore, MD, USA.
    Changes in chloride reversal potential in rat spinal cord neurons have previously been associated with persistent pain in nerve injury and inflammation models. These changes correlate with a decrease in the expression of the potassium chloride transporter, KCC2, and with increases in neuronal excitability. Here, we test the hypothesis that similar changes occur in mice with neuropathic pain induced by chronic constriction injury of the trigeminal infraorbital nerve (CCI-ION). Read More

    Targeting brain-derived neurotrophic factor in the medial thalamus for the treatment of central poststroke pain in a rodent model.
    Pain 2017 Jul;158(7):1302-1313
    Neuroscience, Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan.
    Approximately 7% to 10% of patients develop a chronic pain syndrome after stroke. This chronic pain condition is called central poststroke pain (CPSP). Recent studies have observed an abnormal increase in the secretion of brain-derived neurotrophic factor (BDNF) in spinal cord tissue after spinal cord injury. Read More

    Midazolam as an active placebo in 3 fentanyl-validated nociceptive pain models.
    Pain 2017 Jul;158(7):1264-1271
    aDepartment of Anesthesia, General Intensive Care, and Pain Therapy, Medical University of Vienna, Vienna, Austria bDepartment of Anesthesia, Intensive Care, and Pain Medicine, Wilhelminen Hospital, Vienna, Austria cVienna Human Pain Research Group, Vienna, Austria.
    The use of inactive placebos in early translational trials of potentially analgesic compounds is discouraged because of the side-effect profiles of centrally acting analgesics. Therefore, benzodiazepines are used, although their use has not been validated in this context. Whether benzodiazepines confound the results of acute pain tests is unknown. Read More

    Use of analgesics in young adults as a predictor of health care utilization and pain prevalence: Israel defense forces experience.
    Pain 2017 Jun;158(6):1145-1152
    aIsrael Defense Force Medical Corps, Ramat Gan, Israel bDepartment of Management, Bar-Ilan University, Ramat Gan, Israel cDepartment of Neurology, Soroka University Medical Center, Ben Gurion University of the Negev, Beer-Sheva, Israel.
    Pain evaluation in large community studies is difficult. Analgesics can be a useful tool in estimating pain-related conditions in which analgesic use is highly regulated. In this study, we evaluated analgesics consumption patterns of regular Israel Defense Force soldiers. Read More

    Sickle cell disease: a natural model of acute and chronic pain.
    Pain 2017 Apr;158 Suppl 1:S79-S84
    aDepartment of Pediatrics, Section of Pediatric Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI, USA bChildren's Research Institute of the Children's Hospital of Wisconsin, Milwaukee, WI, USA cDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.

    Psychophysical and psychological predictors of acute pain after breast surgery differ in patients with and without pre-existing chronic pain.
    Pain 2017 Jun;158(6):1030-1038
    aDepartment of Neurology, University of Munich, Munich, Germany Departments of bAnaesthesiology, Intensive Care and Pain Medicine and cObstetrics and Gynecology, University Hospital Muenster, Muenster, Germany.
    The prediction of acute postoperative pain would be of great clinical advantage, but results of studies investigating possible predictors are inconsistent. Here, we studied the role of a wide variety of previously suggested predictors in 74 patients undergoing breast surgery. Preoperatively, patients filled out the Pain Sensitivity Questionnaire (PSQ) and a set of psychological questionnaires (the Beck Depression Inventory [BDI], State-Trait Anxiety Inventory [STAI], and Pain Catastrophizing Scale [PCS]) and participated in an experimental pain testing session, including assessment of conditioned pain modulation (CPM), temporal summation, and responses to heat, pinprick, and pressure pain. Read More

    Predictors of the transition from acute to persistent musculoskeletal pain in children and adolescents: a prospective study.
    Pain 2017 May;158(5):794-801
    aDepartment of Pediatrics, Institute on Development and Disability, Oregon Health & Science University, Portland, OR, USA bDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
    Strategies directed at the prevention of disabling pain have been suggested as a public health priority, making early identification of youth at risk for poor outcomes critical. At present, limited information is available to predict which youth presenting with acute pain are at risk for persistence. The aims of this prospective longitudinal study were to identify biopsychosocial factors in the acute period that predict the transition to persistent pain in youth with new-onset musculoskeletal (MSK) pain complaints. Read More

    Burning pain: axonal dysfunction in erythromelalgia.
    Pain 2017 May;158(5):900-911
    aDepartment of Neurology, Sydney Children's Hospital and School of Women's and Children's Health, University of New South Wales, Sydney, Australia bDepartment of Neurology and Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan cBrain and Mind Centre, The University of Sydney, Sydney, Australia dTranslational Neuroscience Facilities (TNF), Department of Physiology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Randwick, Sydney, Australia.
    Erythromelalgia (EM) is a rare neurovascular disorder characterized by intermittent severe burning pain, erythema, and warmth in the extremities on heat stimuli. To investigate the underlying pathophysiology, peripheral axonal excitability studies were performed and changes with heating and therapy explored. Multiple excitability indices (stimulus-response curve, strength-duration time constant (SDTC), threshold electrotonus, and recovery cycle) were investigated in 23 (9 EMSCN9A+ and 14 EMSCN9A-) genetically characterized patients with EM stimulating median motor and sensory axons at the wrist. Read More

    Does expecting more pain make it more intense? Factors associated with the first week pain trajectories after breast cancer surgery.
    Pain 2017 May;158(5):922-930
    aDivision of Pain Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Finland bBreast Surgery Unit, Comprehensive Cancer Center, University of Helsinki and Helsinki University Hospital, Finland cInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland dDepartment of Public Health, Hjelt Institute, University of Helsinki, Finland.
    The aim of this study was to identify clinical risk factors for unfavorable pain trajectories after breast cancer surgery, to better understand the association between pain expectation, psychological distress, and acute postoperative pain. This prospective study included 563 women treated for breast cancer. Psychological data included questionnaires for depressive symptoms and anxiety. Read More

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