998 results match your criteria Acute Pain[Journal]


Chemotherapy-induced peripheral neuropathy: where are we now?

Authors:
Lesley A Colvin

Pain 2019 May;160 Suppl 1:S1-S10

Chair of Pain Medicine, Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland.

Chemotherapy-induced peripheral neuropathy (CIPN) is a major challenge, with increasing impact as oncological treatments, using potentially neurotoxic chemotherapy, improve cancer cure and survival. Acute CIPN occurs during chemotherapy, sometimes requiring dose reduction or cessation, impacting on survival. Around 30% of patients will still have CIPN a year, or more, after finishing chemotherapy. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001540DOI Listing

Hedonic drinking engages a supraspinal inhibition of thermal nociception in adult rats.

Pain 2019 05;160(5):1059-1069

Department of Neurobiology and Physiology, School of Dentistry, Dental Research Institute, Seoul National University, Seoul, Korea.

The taste of sucrose is commonly used to provide pain relief in newborn humans and is innately analgesic to neonatal rodents. In adulthood, sucrose remains a strong motivator to feed, even in potentially hazardous circumstances (ie, threat of tissue damage). However, the neurobiological mechanisms of this endogenous reward-pain interaction are unclear. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001482DOI Listing
May 2019
1 Read

Remembering the pain of surgery one year later: a longitudinal examination of anxiety in children's pain memory development.

Pain 2019 Apr 6. Epub 2019 Apr 6.

Department of Psychology, York University and Department of Psychology, Hospital for Sick Children.

Children who develop greater negatively biased recall of pain (i.e., recalled pain is higher than the initial pain report) following surgery are at risk for developing chronic pain; therefore, identifying risk factors for the development of biased pain memories is important. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001582DOI Listing

Cortisol affects pain sensitivity and pain-related emotional learning in experimental visceral but not somatic pain: A randomized-controlled study in healthy men and women.

Pain 2019 Apr 6. Epub 2019 Apr 6.

Institute of Medical Psychology & Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Germany.

Despite growing interest in the role of stress mediators in pain chronicity, the effects of the stress hormone cortisol on acute pain remain incompletely understood. In a randomized, double-blind, placebo-controlled study with N=100 healthy volunteers, we tested the effects of oral hydrocortisone (20 mg) in two widely-used pain models for the visceral and somatic modality.Salivary cortisol was increased in the hydrocortisone group (time x group: p<. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001579DOI Listing

HOW ARE PAIN AND TRAUMATIC STRESS SYMPTOMS RELATED IN ACUTE WHIPLASH ASSOCIATED DISORDERS? AN INVESTIGATION OF THE ROLE OF PAIN-RELATED FEAR IN A DAILY DIARY STUDY.

Pain 2019 Apr 10. Epub 2019 Apr 10.

Recover Injury Research Centre, The University of Queensland.

Comorbidity of pain and posttraumatic stress disorder is well recognized but the reason for this association is unclear. This study investigated the direction of the relationship between pain and traumatic stress and the role that pain-related fear plays, for patients with acute whiplash associated disorder (WAD). Participants (n = 99) used an electronic diary to record hourly ratings of pain, traumatic stress and fear-of-pain symptoms over a day. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001581DOI Listing
April 2019
2 Reads

Platelet-derived growth factor activates nociceptive neurons by inhibiting M-current and contributes to inflammatory pain.

Pain 2019 Feb 19. Epub 2019 Feb 19.

Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah School of Medicine, Jerusalem, Israel.

Endogenous inflammatory mediators contribute to the pathogenesis of pain by acting on nociceptors, specialized sensory neurons that detect noxious stimuli. Here, we describe a new factor mediating inflammatory pain. We show that platelet-derived growth factor (PDGF)-BB applied in vitro causes repetitive firing of dissociated nociceptor-like rat dorsal root ganglion neurons and decreased their threshold for action potential generation. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001523DOI Listing
February 2019
1 Read

Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy.

Pain 2019 Feb 5. Epub 2019 Feb 5.

Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States.

Inhibition of voltage-gated calcium (CaV) channels is a potential therapy for many neurological diseases including chronic pain. Neuronal CaV1/CaV2 channels are composed of α, β, γ and α2δ subunits. The β subunits of CaV channels are cytoplasmic proteins that increase the surface expression of the pore-forming α subunit of CaV. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001524DOI Listing
February 2019
7 Reads
5.213 Impact Factor

Genetic mapping in Diversity Outbred mice identifies a Trpa1 variant influencing late-phase formalin response.

Pain 2019 Mar 27. Epub 2019 Mar 27.

The Jackson Laboratory 600 Main Street, Bar Harbor, ME 04609, USA.

Identification of genetic variants that influence susceptibility to pain is key to identifying molecular mechanisms and targets for effective and safe therapeutic alternatives to opioids. To identify genes and variants associated with persistent pain, we measured late phase response to formalin injection in 275 male and female Diversity Outbred (DO) mice genotyped for over 70 thousand SNPs. One quantitative trait locus (QTL) reached genome-wide significance on chromosome 1 with a support interval of 3. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001571DOI Listing
March 2019
4 Reads

Pain-related functional interference in patients with chronic neuropathic postsurgical pain: an analysis of registry data.

Pain 2019 Mar 21. Epub 2019 Mar 21.

Hôpital Ambroise Paré, 9 avenue Charles de Gaulle 92100, Boulogne Billancourt, France.

Although chronic postsurgical pain (CPSP) is a major health care problem, pain-related functional interference has rarely been investigated. Using the PAIN OUT registry we evaluated patients' pain-related outcomes on the first postoperative day, and their pain-related interference with daily living (Brief Pain Inventory) and neuropathic symptoms (DN4: douleur neuropathique en 4 questions) at six months after surgery. Endpoints were pain interference total scores (PITS) and their association with pain and DN4 scores. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001560DOI Listing

Progesterone relates to enhanced incisional acute pain and pinprick hyperalgesia in the luteal phase of female volunteers.

Pain 2019 Mar 21. Epub 2019 Mar 21.

Department of Anaesthesiology, Intensive Care Medicine.

The role of sex hormones on postsurgical pain perception is basically unclear. Here we studied the role of endogenous gonadal hormones for pain and hyperalgesia in human volunteers after experimental incision.A 4-mm incision was made in the volar forearm of 15 female volunteers both in the follicular and the luteal phase (random block design). Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001561DOI Listing
March 2019
1 Read

Anti-allodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute post-surgical pain: evidence for analgesic synergy with opioids and baclofen.

Pain 2019 Mar 21. Epub 2019 Mar 21.

Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.

Pain is the leading cause of disability in the developed world but remains a poorly treated condition. Specifically, post-surgical pain continues to be a frequent and undermanaged condition. Here, we investigate the analgesic potential of pharmacological NaV1. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001567DOI Listing

Haploinsufficiency of the brain-derived neurotrophic factor gene is associated with reduced pain sensitivity.

Pain 2019 05;160(5):1070-1081

Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health (NIH), Bethesda, MD, United States.

Rare pain-insensitive individuals offer unique insights into how pain circuits function and have led to the development of new strategies for pain control. We investigated pain sensitivity in humans with WAGR (Wilms tumor, aniridia, genitourinary anomaly, and range of intellectual disabilities) syndrome, who have variably sized heterozygous deletion of the 11p13 region. The deletion region can be inclusive or exclusive of the brain-derived neurotrophic factor (BDNF) gene, a crucial trophic factor for nociceptive afferents. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476691PMC
May 2019
1 Read

Efficacy and safety of loxoprofen sodium topical patch for the treatment of pain in patients with minor acute traumatic limb injuries in Brazil: a randomized, double-blind, noninferiority trial.

Pain 2019 Mar 4. Epub 2019 Mar 4.

Daiichi Sankyo Brasil, Clinical Research Department, São Paulo, Brazil.

Posttraumatic injury pain is commonly treated with oral nonsteroidal anti-inflammatory drugs. However, oral nonsteroidal anti-inflammatory drugs cause several adverse events, with topical formulations arising as an important alternative. Therefore, we aimed at evaluating the efficacy and safety of loxoprofen patch (LX-P) in the treatment of patients with posttraumatic pain. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001549DOI Listing
March 2019
1 Read

Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain.

Pain 2019 Apr;160(4):932-944

Alan Edwards Centre for Research on Pain, McGill University, Montre[Combining Acute Accent]al, QC, Canada.

Chronic pain is a debilitating and poorly treated condition whose underlying mechanisms are poorly understood. Nerve injury and inflammation cause alterations in gene expression in tissues associated with pain processing, supporting molecular and cellular mechanisms that maintain painful states. However, it is not known whether transcriptome changes can be used to reconstruct a molecular pathophysiology of pain. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001471DOI Listing
April 2019
9 Reads

The serum protease network - one key to understand Complex Regional Pain Syndrome pathophysiology.

Pain 2019 Jan 28. Epub 2019 Jan 28.

Department of Neurology, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.

Complex Regional Pain Syndrome (CRPS) develops after fracture. The acute CRPS phenotype resembles exaggerated inflammation which is explained by local and systemic activation of a pro-inflammatory network including peptides and cytokines. Epidemiologic data suggest that inactivation of the peptidase angiotensin converting enzyme (ACE) in patients treated for hypertension increases the odds to develop CRPS. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001503DOI Listing
January 2019
2 Reads

Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain.

Pain 2019 Apr;160(4):824-832

Department of Pharmacology, Arizona Health Sciences Center, University of Arizona, Tucson, AZ, United States.

Chronic pain is associated with neuroplastic changes in the amygdala that may promote hyper-responsiveness to mechanical and thermal stimuli (allodynia and hyperalgesia) and/or enhance emotional and affective consequences of pain. Stress promotes dynorphin-mediated signaling at the kappa opioid receptor (KOR) in the amygdala and mechanical hypersensitivity in rodent models of functional pain. Here, we tested the hypothesis that KOR circuits in the central nucleus of the amygdala (CeA) undergo neuroplasticity in chronic neuropathic pain resulting in increased sensory and affective pain responses. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424634PMC
April 2019
2 Reads

Hedonic drinking engages a supra-spinal inhibition of thermal nociception in adult rats.

Pain 2019 Jan 11. Epub 2019 Jan 11.

Dental Research Institute and Department of Neurobiology and Physiology, School of Dentistry, Seoul National University, Republic of Korea.

The taste of sucrose is commonly used to provide pain relief in newborn humans and is innately analgesic to neonatal rodents. In adulthood, sucrose remains a strong motivator to feed, even in potentially hazardous circumstances (i.e. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001482DOI Listing
January 2019
10 Reads

Intact mast cell content during mild head injury is required for development of latent pain sensitization: implications for mechanisms underlying post-traumatic headache.

Authors:
Dara Bree Dan Levy

Pain 2019 05;160(5):1050-1058

Departments of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States.

Post-traumatic headache (PTH) is one of the most common, debilitating, and difficult symptoms to manage after a traumatic head injury. Although the mechanisms underlying PTH remain elusive, recent studies in rodent models suggest the potential involvement of calcitonin gene-related peptide (CGRP), a mediator of neurogenic inflammation, and the ensuing activation of meningeal mast cells (MCs), proalgesic resident immune cells that can lead to the activation of the headache pain pathway. Here, we investigated the relative contribution of MCs to the development of PTH-like pain behaviors in a model of mild closed-head injury (mCHI) in male rats. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476678PMC
May 2019
2 Reads

The IASP classification of chronic pain for ICD-11: chronic neuropathic pain.

Pain 2019 Jan;160(1):53-59

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

The upcoming 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD) of the World Health Organization (WHO) offers a unique opportunity to improve the representation of painful disorders. For this purpose, the International Association for the Study of Pain (IASP) has convened an interdisciplinary task force of pain specialists. Here, we present the case for a reclassification of nervous system lesions or diseases associated with persistent or recurrent pain for ≥3 months. Read More

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http://Insights.ovid.com/crossref?an=00006396-201901000-0000
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http://dx.doi.org/10.1097/j.pain.0000000000001365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310153PMC
January 2019
22 Reads
5.213 Impact Factor

The IASP classification of chronic pain for ICD-11: chronic postsurgical or posttraumatic pain.

Pain 2019 Jan;160(1):45-52

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Germany.

Chronic pain after tissue trauma is frequent and may have a lasting impact on the functioning and quality of life of the affected person. Despite this, chronic postsurgical and posttraumatic pain is underrecognised and, consequently, undertreated. It is not represented in the current International Classification of Diseases (ICD-10). Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001413DOI Listing
January 2019
2 Reads

Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11).

Pain 2019 Jan;160(1):19-27

The Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.

Chronic pain is a major source of suffering. It interferes with daily functioning and often is accompanied by distress. Yet, in the International Classification of Diseases, chronic pain diagnoses are not represented systematically. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001384DOI Listing
January 2019
11 Reads
5.213 Impact Factor

Somatosensory profiles in acute herpes zoster and predictors of postherpetic neuralgia.

Pain 2019 Apr;160(4):882-894

Department of Anaesthesiology, Multidisciplinary Pain Centre, University Hospital LMU Munich, Munich, Germany.

This prospective cohort study aimed to characterize the sensory profile during acute herpes zoster (AHZ) and to explore sensory signs as well as physical and psychosocial health as predictors for postherpetic neuralgia (PHN). Results of quantitative sensory testing of 74 patients with AHZ at the affected site and at the distant contralateral control site were compared to a healthy control group. Pain characteristics (Neuropathic Pain and Symptom Inventory and SES), physical functioning, and psychosocial health aspects (Pain Disability Index, SF-36, and STAI) were assessed by questionnaires. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001467DOI Listing
April 2019
17 Reads

Medicine use during acute and chronic postinjury periods in whiplash-injured individuals.

Pain 2019 Apr;160(4):844-851

Recover Injury Research Centre, The University of Queensland, Herston, Queensland, Australia.

Medicine use as part of multimodal management for whiplash-associated disorders (WAD) is common: neck pain is the cardinal symptom, mental health conditions are common, and some individuals may have neurological signs and symptoms. Almost half of the individuals with WAD have ongoing pain and disability. However, medicine use during acute and chronic recovery periods for WAD management is unknown. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001460DOI Listing
April 2019
7 Reads

Functional brain activity during motor control and pain processing in chronic jaw pain.

Pain 2018 Dec;159(12):2547-2564

Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United States.

Changes in brain function in chronic pain have been studied using paradigms that deliver acute pain-eliciting stimuli or assess the brain at rest. Although motor disability accompanies many chronic pain conditions, few studies have directly assessed brain activity during motor function in individuals with chronic pain. Using chronic jaw pain as a model, we assessed brain activity during a precisely controlled grip force task and during a precisely controlled pain-eliciting stimulus on the forearm. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001366DOI Listing
December 2018
17 Reads

Children and adolescents with sickle cell disease have worse cold and mechanical hypersensitivity during acute painful events.

Pain 2019 Feb;160(2):407-416

Section of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, United States.

Sickle cell disease (SCD) pain associates with cold temperature and touch. Patients and murine models with SCD have baseline thermal and mechanical pain. In SCD mice, the baseline hypersensitivity is exacerbated by experimental vaso-occlusive crises. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001407DOI Listing
February 2019
1 Read

Contribution of dorsal root ganglion octamer transcription factor 1 to neuropathic pain after peripheral nerve injury.

Pain 2019 Feb;160(2):375-384

Department of Anesthesiology, New Jersey Medical School, Rutgers the State University of New Jersey, Newark, NJ, United States.

Neuropathic pain genesis is related to gene alterations in the dorsal root ganglion (DRG) after peripheral nerve injury. Transcription factors control gene expression. In this study, we investigated whether octamer transcription factor 1 (OCT1), a transcription factor, contributed to neuropathic pain caused by chronic constriction injury (CCI) of the sciatic nerve. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344274PMC
February 2019
6 Reads
5.210 Impact Factor

Recommendations for selection of self-report pain intensity measures in children and adolescents: a systematic review and quality assessment of measurement properties.

Pain 2019 01;160(1):5-18

Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada.

In 2006, PAIN published a systematic review of the measurement properties of self-report pain intensity measures in children and adolescents (Stinson JN, Kavanagh T, Yamada J, Gill N, Stevens B. Systematic review of the psychometric properties, interpretability and feasibility of self-report pain intensity measures for use in clinical trials in children and adolescents. PAIN 2006;125:143-57). Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001377DOI Listing
January 2019
15 Reads

Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.

Pain 2019 Jan;160(1):136-150

Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, Montreal, QC, Canada.

Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of cannabis that interacts with the serotonin (5-HT)1A receptor, may possess analgesic and anxiolytic effects. However, its effects on 5-HT neuronal activity, as well as its impact on models of neuropathic pain are unknown. First, using in vivo single-unit extracellular recordings in rats, we demonstrated that acute intravenous (i. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319597PMC
January 2019
31 Reads
5.213 Impact Factor

Morphine effects within the rodent anterior cingulate cortex and rostral ventromedial medulla reveal separable modulation of affective and sensory qualities of acute or chronic pain.

Pain 2018 Dec;159(12):2512-2521

Department of Pharmacology, University of Arizona, Tucson, AZ, United States.

Modulation of pain may result from engagement of opioid receptors in multiple brain regions. Whether sensory and affective qualities of pain are differentially affected by brain opioid receptor circuits remains unclear. We previously reported that opioid actions within the rostral anterior cingulate cortex (ACC) produce selective modulation of affective qualities of neuropathic pain in rodents, but whether such effects may occur in other areas of the ACC is not known. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320264PMC
December 2018
19 Reads

Isolated nociceptors reveal multiple specializations for generating irregular ongoing activity associated with ongoing pain.

Pain 2018 Nov;159(11):2347-2362

Department of Integrative Biology and Pharmacology, McGovern Medical School at UTHealth, Houston, TX, United States.

Ongoing pain has been linked to ongoing activity (OA) in human C-fiber nociceptors, but rodent models of pain-related OA have concentrated on allodynia rather than ongoing pain, and on OA generated in non-nociceptive Aβ fibers rather than C-fiber nociceptors. Little is known about how ongoing pain or nociceptor OA is generated. To define neurophysiological alterations underlying nociceptor OA, we have used isolated dorsal root ganglion neurons that continue to generate OA after removal from animals displaying ongoing pain. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193853PMC
November 2018
10 Reads

Complex regional pain syndrome: intradermal injection of phenylephrine evokes pain and hyperalgesia in a subgroup of patients with upregulated α1-adrenoceptors on dermal nerves.

Pain 2018 Nov;159(11):2296-2305

Danish Pain Research Center, Aarhus University Hospital, Aarhus, Denmark.

The aim of this study was to determine whether upregulated cutaneous expression of α1-adrenoceptors (α1-AR) is a source of pain in patients with complex regional pain syndrome (CRPS). Immunohistochemistry was used to identify α1-AR on nerve fibres and other targets in the affected and contralateral skin of 90 patients, and in skin samples from 38 pain-free controls. The distribution of α1-AR was compared between patients and controls, and among subgroups of patients defined by CRPS duration, limb temperature asymmetry, and diagnostic subtype (CRPS I vs CRPS II). Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001335DOI Listing
November 2018
31 Reads

Estimating relative efficacy in acute postoperative pain: network meta-analysis is consistent with indirect comparison to placebo alone.

Pain 2018 Nov;159(11):2234-2244

Centre for Pain Research, University of Bath, Bath, United Kingdom.

Network meta-analysis uses direct comparisons of interventions within randomized controlled trials and indirect comparisons across them. Network meta-analysis uses more data than a series of direct comparisons with placebo, and theoretically should produce more reliable results. We used a Cochrane overview review of acute postoperative pain trials and other systematic reviews to provide data to test this hypothesis. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203421PMC
November 2018
9 Reads

Efficacy of hypnosis on pain, wound-healing, anxiety, and stress in children with acute burn injuries: a randomized controlled trial.

Pain 2018 Sep;159(9):1790-1801

Center for Children's Burns and Trauma Research, Level 7, Children's Health Research Center, The University of Queensland, South Brisbane, Queensland, Australia.

No randomized controlled trial has investigated the efficacy of hypnosis for reducing pain and improving wound-healing in children with burns. This randomized controlled trial aimed to investigate whether hypnosis decreases pain, anxiety, and stress and accelerates wound-healing in children undergoing burn wound procedures. Children (4-16 years) with acute burns presenting for their first dressing change were randomly assigned to a Hypnosis Group who received hypnosis plus standard care or a Standard Care Group who received standard pharmacological and nonpharmacological intervention. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001276DOI Listing
September 2018
37 Reads
5.213 Impact Factor

Color-selective photophobia in ictal vs interictal migraineurs and in healthy controls.

Pain 2018 Oct;159(10):2030-2034

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States.

Aversion to light is common among migraineurs undergoing acute attacks. Using psychophysical assessments in patients with episodic migraine, we reported that white, blue, amber, and red lights exacerbate migraine headache in a significantly larger percentage of patients and to a greater extent compared with green light. This study aimed at determining whether these findings are phase-dependent-namely, manifested exclusively during migraine (ictally) but not in its absence (interictally), or condition-dependent-ie, expressed uniquely in migraineurs but not in healthy controls. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347023PMC
October 2018
50 Reads

Why wait to address high-risk cases of acute low back pain? A comparison of stepped, stratified, and matched care.

Pain 2018 Dec;159(12):2437-2441

Division of Occupational and Environmental Medicine, University of Connecticut Health Center, United States.

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http://dx.doi.org/10.1097/j.pain.0000000000001308DOI Listing
December 2018
5 Reads

Patterns of recovery from pain after cesarean delivery.

Pain 2018 Oct;159(10):2088-2096

Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, United States.

We know very little about the change in pain in the first 2 months after surgery. To address this gap, we studied 530 women scheduled for elective cesarean delivery who completed daily pain diaries for 2 months after surgery through text messaging. Over 82% of subjects missed fewer than 10 diary entries and were included in the analysis. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328056PMC
October 2018
6 Reads

Trigeminal ganglion transcriptome analysis in 2 rat models of medication-overuse headache reveals coherent and widespread induction of pronociceptive gene expression patterns.

Pain 2018 Oct;159(10):1980-1988

Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy.

We attempted to gather information on the pathogenesis of medication-overuse headache, as well as on the neurochemical mechanisms through which symptomatic medication overuse concurs to headache chronification. Transcriptional profiles were therefore evaluated as an index of the homeostasis of the trigeminovascular system in the trigeminal ganglion of female rats exposed for 1 month to daily oral doses of eletriptan or indomethacin. We report that both drug treatments change trigeminal ganglion gene expression to a similar extend. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001291DOI Listing
October 2018
6 Reads

Chronic neuropathic pain reduces opioid receptor availability with associated anhedonia in rat.

Pain 2018 Sep;159(9):1856-1866

Division of Intramural Research, National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD, United States.

The opioid system plays a critical role in both the experience and management of pain. Although acute activation of the opioid system can lead to pain relief, the effects of chronic pain on the opioid system remain opaque. Cross-sectional positron emission tomography (PET) studies show reduced availability of brain opioid receptors in patients with chronic pain but are unable to (1) determine whether these changes are due to the chronic pain itself or due to preexisting or medication-induced differences in the endogenous opioid system, and (2) identify the neurobiological substrate of reduced opioid receptor availability. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095806PMC
September 2018
6 Reads

Hemisensory disturbances in patients with complex regional pain syndrome.

Pain 2018 Sep;159(9):1824-1832

Danish Pain Research Center, Aarhus University Hospital, Aarhus, Denmark.

Sensory disturbances often spread beyond the site of injury in complex regional pain syndrome (CRPS) but whether this applies equally to CRPS I and II, or changes across the course of the disease, is unknown. Establishing this is important, because different symptom profiles in CRPS I and II, or in acute vs chronic CRPS, might infer different pathophysiology and treatment approaches. To explore these questions, sensory disturbances were assessed in the limbs and forehead of 71 patients with CRPS I and 33 patients with CRPS II. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001280DOI Listing
September 2018
6 Reads

"From ear to trunk"-magnetic resonance imaging reveals referral of pain.

Pain 2018 Sep;159(9):1900-1903

Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Referred and projecting pain can be observed in acute and chronic pain states. We present the case of a 69-year-old female patient with postherpetic neuralgia in dermatome Th2/3 who reported that touching the ipsilateral earlap (dermatome C2) would enhance pain and dynamic mechanical allodynia in the affected Th2/3-dermatome. The aim was to investigate possible underlying mechanisms of this phenomenon using the capsaicin experimental pain sensitization model, quantitative sensory testing, and functional spinal and supraspinal magnetic resonance imaging. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001279DOI Listing
September 2018
12 Reads

Peripherally restricted cannabinoid 1 receptor agonist as a novel analgesic in cancer-induced bone pain.

Pain 2018 Sep;159(9):1814-1823

Departments of Pharmacology and.

Many malignant cancers, including breast cancer, have a propensity to invade bones, leading to excruciating bone pain. Opioids are the primary analgesics used to alleviate this cancer-induced bone pain (CIBP) but are associated with numerous severe side effects, including enhanced bone degradation, which significantly impairs patients' quality of life. By contrast, agonists activating only peripheral CB1 receptors (CB1Rs) have been shown to effectively alleviate multiple chronic pain conditions with limited side effects, yet no studies have evaluated their role(s) in CIBP. Read More

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http://Insights.ovid.com/crossref?an=00006396-900000000-9895
Publisher Site
http://dx.doi.org/10.1097/j.pain.0000000000001278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095738PMC
September 2018
10 Reads

A bifunctional-biased mu-opioid agonist-neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects.

Pain 2018 Sep;159(9):1705-1718

Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.

Opioid analgesics, such as morphine, oxycodone, and fentanyl, are the cornerstones for treating moderate to severe pain. However, on chronic administration, their efficiency is limited by prominent side effects such as analgesic tolerance and dependence liability. Neuropeptide FF (NPFF) and its receptors (NPFF1R and NPFF2R) are recognized as an important pronociceptive system involved in opioid-induced hyperalgesia and analgesic tolerance. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001262DOI Listing
September 2018
10 Reads

Chemokine (c-c motif) receptor 2 mediates mechanical and cold hypersensitivity in sickle cell disease mice.

Pain 2018 Aug;159(8):1652-1663

Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, United States.

Approximately one-third of individuals with sickle cell disease (SCD) develop chronic pain. This debilitating pain is inadequately treated because the underlying mechanisms driving the pain are poorly understood. In addition to persistent pain, patients with SCD are also in a tonically proinflammatory state. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317856PMC
August 2018
5 Reads

Spinal protein kinase C/extracellular signal-regulated kinase signal pathway mediates hyperalgesia priming.

Pain 2018 May;159(5):907-918

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Chronic pain can be initiated by one or more acute stimulations to sensitize neurons into the primed state. In the primed state, the basal nociceptive thresholds of the animal are normal, but, in response to another hyperalgesic stimulus, the animal develops enhanced and prolonged hyperalgesia. The exact mechanism of how primed state is formed is not completely understood. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001162DOI Listing
May 2018
8 Reads

Dyadic analysis of siblings' relationship quality, behavioural responses, and pain experiences during experimental pain.

Pain 2018 Aug;159(8):1569-1579

Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada.

Research on family factors in paediatric pain has primarily focused on parents; the role of siblings has been largely ignored. This study examined whether sibling relationship quality was related to siblings' behaviours during experimental pain, and whether the behaviours of an observing sibling were related to children's pain outcomes. Ninety-two sibling dyads between 8 and 12 years old completed both observational and questionnaire measures of sibling relationship quality. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001244DOI Listing
August 2018
4 Reads

Comparison of the psychometric properties of 3 pain scales used in the pediatric emergency department: Visual Analogue Scale, Faces Pain Scale-Revised, and Colour Analogue Scale.

Pain 2018 Aug;159(8):1508-1517

Women and Children's Health Research Institute, Edmonton, AB, Canada.

Appropriate pain measurement relies on the use of valid, reliable tools. The aim of this study was to determine and compare the psychometric properties of 3 self-reported pain scales commonly used in the pediatric emergency department (ED). The inclusion criteria were children aged 6 to 17 years presenting to the ED with a musculoskeletal injury and self-reported pain scores ≥30 mm on the mechanical Visual Analogue Scale (VAS). Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001236DOI Listing
August 2018
11 Reads

Early workplace dialogue in physiotherapy practice improved work ability at 1-year follow-up-WorkUp, a randomised controlled trial in primary care.

Pain 2018 Aug;159(8):1456-1464

Department of Clinical Sciences Lund, Orthopedics, Lund University, Lund, Sweden.

Workplace involvement in rehabilitation for patients with musculoskeletal pain may improve work ability. Convergence Dialogue Meeting (CDM) is a model aimed at helping the patient, the care giver, and the employer to support work ability and return-to-work. Our aim was to study the effect on work ability when adding a workplace dialogue according to CDM in physiotherapy practice for patients with pain in ordinary primary care. Read More

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http://Insights.ovid.com/crossref?an=00006396-201808000-0000
Publisher Site
http://dx.doi.org/10.1097/j.pain.0000000000001216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085128PMC
August 2018
10 Reads

Carbenoxolone as a novel therapy for attenuation of cancer-induced bone pain.

Authors:
Sarah Falk

Pain 2018 Jun;159(6):1127-1136

Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.

Pain is a major complication for patients with cancer significantly compromising their quality of life. Current treatment is far from optimal and particularly bone-related cancer pain poses an increasing clinical and socioeconomical problem. Connexins, key proteins in cell-cell communication, have the potential to affect cancer-induced bone pain at multiple levels, including nociceptive signaling and bone degradation. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001197DOI Listing
June 2018
9 Reads

Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity.

Pain 2018 Jun;159(6):1012-1024

Applied Human Molecular Genetics, Clinical Genetic Clinic, Kennedy Center, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.

Human studies have demonstrated a correlation between noncoding polymorphisms of "the pain protective" haplotype in the GCH1 gene that encodes for GTP cyclohydrolase I (GTPCH1)-which leads to reduced tetrahydrobiopterin (BH4) production in cell systems-and a diminished perception of experimental and clinical pain. Here, we investigate whether heterozygous mutations in the GCH1 gene which lead to a profound BH4 reduction in patients with dopa-responsive dystonia (DRD) have any effect on pain sensitivity. The study includes an investigation of GCH1-associated biomarkers and pain sensitivity in a cohort of 22 patients with DRD and 36 controls. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001175DOI Listing
June 2018
24 Reads
5.213 Impact Factor

Racial differences in presentations and predictors of acute pain after motor vehicle collision.

Pain 2018 Jun;159(6):1056-1063

Anesthesiology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA.

African Americans experience a greater burden of acute pain than non-Hispanic white individuals across of variety of acute medical conditions, but it is unknown whether this is the case after trauma. We evaluated pain, pain-related characteristics (eg, peritraumatic distress), and analgesic treatment in 2 cohorts of individuals (African American [n = 931] and non-Hispanic white [n = 948]) presenting to the emergency department (ED) after a motor vehicle collision. We performed a propensity-matched analysis (n = 796 in each group) to assess racial differences in acute pain in the ED. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001186DOI Listing
June 2018
10 Reads