1,026 results match your criteria Acute Pain[Journal]


Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability.

Pain 2020 May 13. Epub 2020 May 13.

Laboratory of Neuroimmunology, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

Understanding the mechanisms that drive transition from acute to chronic pain is essential to identify new therapeutic targets. The importance of endogenous resolution pathways acting as a "brake" to prevent development of chronic pain has been largely ignored. We examined the role of IL-10 in resolution of neuropathic pain induced by cisplatin. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001921DOI Listing

The transition from acute to chronic pain: dynamic epigenetic reprogramming of the mouse prefrontal cortex up to one year following nerve injury.

Pain 2020 May 8. Epub 2020 May 8.

Alan Edwards Centre for Research on Pain, McGill University.

Chronic pain is associated with persistent structural and functional changes throughout the neuroaxis, including in the prefrontal cortex (PFC). The PFC is important in the integration of sensory, cognitive and emotional information and in conditioned pain modulation. We previously reported wide-spread epigenetic reprogramming in the PFC many months following nerve injury in rodents. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001917DOI Listing

Daily intermittent fasting in mice enhances morphine-induced anti-nociception while mitigating reward, tolerance, and constipation.

Pain 2020 May 8. Epub 2020 May 8.

Department of Pharmacology, College of Medicine, University of Arizona, Tucson AZ USA.

The opioid epidemic has plagued the United States with high levels of abuse and poor quality of life for chronic pain patients requiring continuous use of opioids. New drug discovery efforts have been implemented to mitigate this epidemic, however, new medications are still limited by low efficacy and/or high side effect and abuse potential. Intermittent fasting (IF) has recently been shown to improve a variety of pathological states, including stroke and neuroinflammation. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001918DOI Listing

Acute visceral pain relief mediated by A3AR agonists in rats: involvement of N-type voltage-gated calcium channels.

Pain 2020 May 4. Epub 2020 May 4.

Dept. of Neuroscience, Psychology, Drug Research and Child Health - Neurofarba - Division of Pharmacology and Toxicology, 50139 Florence, Italy.

Pharmacological tools for chronic visceral pain management are still limited and inadequate. A3 adenosine receptor (A3AR) agonists are effective in different models of persistent pain. Recently their activity has been related to the block of N-type voltage-gated Ca channels (Cav2. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001905DOI Listing
May 2020
5.213 Impact Factor

Imbalance of pro-resolving lipid mediators in persistent allodynia dissociated from signs of clinical arthritis.

Pain 2020 May 4. Epub 2020 May 4.

Wolfson Centre for Age Related Diseases, King's College London, London SE1 1UL, UK.

Rheumatoid arthritis-associated pain is poorly managed, often persisting when joint inflammation is pharmacologically controlled. Comparably, in the mouse K/BxN serum-transfer model of inflammatory arthritis, hind-paw nociceptive hypersensitivity occurs with ankle joint swelling (5 days post-immunisation) persisting after swelling has resolved (25 days post-immunisation). In this study, lipid mediator profiling of lumbar dorsal root ganglia (DRG), the site of sensory neuron cell bodies innervating the ankle joints, 5 days and 25 days after serum transfer demonstrated a shift in specialised pro-resolving lipid mediator (SPM) profiles. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001908DOI Listing

Associations between obstructive sleep apnea and prescribed opioids among veterans.

Pain 2020 Apr 29. Epub 2020 Apr 29.

Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

Sleep disruption caused by obstructive sleep apnea (OSA) may be associated with hyperalgesia and may contribute to poor pain control and use of prescription opioids. However, the relationship between OSA and opioid prescription is not well described. We examine this association using cross-sectional data from a national cohort of veterans from recent wars enrolled from October 1, 2001 to October 7, 2014. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001906DOI Listing

Virtual reality: physiological and behavioral mechanisms to increase individual pain tolerance limits.

Pain 2020 Apr 24. Epub 2020 Apr 24.

Division of Trauma and Critical Care, R Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, Maryland, US.

Immersive Virtual Reality (VR) consists of immersion in artificial environments through the use of real-time render technologies and the latest generation devices. The users feel just as immersed as they would feel in an everyday life situation and this sense of presence appears to have therapeutic potentials. However, the VR mechanisms remain only partially known. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001900DOI Listing

Postnatal maturation of spinal dynorphin circuits and their role in somatosensation.

Pain 2020 Apr 1. Epub 2020 Apr 1.

Neuroscience Graduate Program, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA.

Inhibitory interneurons in the adult spinal dorsal horn (DH) can be neurochemically classified into subpopulations that regulate distinct somatosensory modalities. Although inhibitory networks in the rodent DH undergo dramatic remodeling over the first weeks of life, little is known about the maturation of identified classes of GABAergic interneurons, or whether their role in somatosensation shifts during development. We investigated age-dependent changes in the connectivity and function of prodynorphin (DYN)-lineage neurons in the mouse DH that suppress mechanosensation and itch during adulthood. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001884DOI Listing

Physical disuse contributes to widespread chronic mechanical hyperalgesia, tactile allodynia, and cold allodynia through neurogenic inflammation and spino-parabrachio-amygdaloid pathway activation.

Pain 2020 Mar 13. Epub 2020 Mar 13.

Department of Anatomy, Aichi Medical University, Aichi 480-1195, Japan.

Physical disuse could lead to a state of chronic pain typified by complex regional pain syndrome type I due to fear of pain through movement (kinesiophobia) or inappropriate resting procedures. However, the mechanisms by which physical disuse is associated with acute/chronic pain and other pathological signs remain unresolved. We have previously reported that inflammatory signs, contractures, disuse muscle atrophy, spontaneous pain-like behaviors, and chronic widespread mechanical hyperalgesia based on central plasticity occurred after 2-weeks of cast immobilization in chronic post-cast pain (CPCP) rat model. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001867DOI Listing

An examination of the reciprocal and concurrent relations between behavioral and cardiac indicators of acute pain in toddlerhood.

Pain 2020 Feb 18. Epub 2020 Feb 18.

University of Toronto, Toronto, Ontario, Canada.

The aim of this study was to examine the concurrent and predictive relations between healthy toddlers' pain behavior and cardiac indicators (i.e., heart rate [HR], respiratory sinus arrhythmia [RSA]) during routine vaccinations. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001840DOI Listing
February 2020

Alterations in pronociceptive and antinociceptive mechanisms in patients with low back pain: a systematic review with meta-analysis.

Pain 2020 03;161(3):464-475

Department of Health Science and Technology, Center for Neuroplasticity and Pain (CNAP), SMI, Aalborg University, Aalborg, Denmark.

Altered pronociceptive and antinociceptive mechanisms are often implicated in painful conditions and have been increasingly studied over the past decade. For some painful conditions, alterations are well-established, but in populations with low back pain (LBP), there remains considerable debate whether these mechanisms are altered. The present systematic review aimed to address this issue by identifying studies assessing conditioned pain modulation (CPM) and/or temporal summation of pain (TSP) in patients with LBP, comparing with either a healthy control group or using a method with reference data available. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001737DOI Listing

Nociceptive input after peripheral nerve injury results in cognitive impairment and alterations in primary afferent physiology in rats.

Pain 2020 May;161(5):960-969

Pain Mechanisms Lab, Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, United States.

Pain alters cognitive performance through centrally mediated effects in the brain. In this study, we hypothesized that persistent activation of peripheral nociceptors after injury would lead to the development of a chronic pain state that impairs attention-related behavior and results in changes in peripheral neuron phenotypes. Attentional performance was measured in rats using the 5-choice serial reaction time titration variant to determine the initial impact of partial L5 spinal nerve ligation and the effect of persistent nociceptor activation on the resolution of injury. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166154PMC

Low-dose interleukin-2 reverses behavioral sensitization in multiple mouse models of headache disorders.

Pain 2020 Jun;161(6):1381-1398

Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, United States.

Headache disorders are highly prevalent and debilitating, with limited treatment options. Previous studies indicate that many proinflammatory immune cells contribute to headache pathophysiology. Given the well-recognized role of regulatory T (Treg) cells in maintaining immune homeostasis, we hypothesized that enhancing Treg function may be effective to treat multiple headache disorders. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230033PMC
June 2020
5.213 Impact Factor

Pharmacological characterization of a rat Nav1.7 loss-of-function model with insensitivity to pain.

Pain 2020 Jun;161(6):1350-1360

Department of Neurology, Yale University School of Medicine, New Haven, CT, United States.

Sodium channel Nav1.7, encoded by the SCN9A gene, is a well-validated target that plays a key role in controlling pain sensation. Loss-of-function mutations of Nav1. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001807DOI Listing

The dichotomous role of epiregulin in pain.

Pain 2020 May;161(5):1052-1064

The Alan Edwards Centre for Research on Pain, Department of Anesthesia, Faculty of Medicine, Faculty of Dentistry, McGill University, Montreal, QC, Canada.

It has recently been shown that epidermal growth factor receptor (EGFR) contributes to the pathogenesis of pain. We scanned genetic markers within genes coding for receptors of the EGFR family (EGFR, ERBB2, ERBB3, and ERBB4) and their ligands (AREG, BTC, EGF, EPGN, EREG, HBEGF, MUC4, NRG1, NRG2, NRG3, NRG4, and TGFA) for association with self-reported pain intensity in patients with chronic facial pain who participated in the Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) cohort. We found that only epiregulin (EREG) was associated with pain. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166142PMC

Regular dosing compared with as-needed dosing of opioids for management of chronic cancer pain: systematic review and meta-analysis.

Pain 2020 Apr;161(4):703-712

Academic Unit of Palliative Care, University of Leeds, Leeds, United Kingdom.

Opioids are the recommended form of analgesia for patients with persistent cancer pain, and regular dosing "by the clock" is advocated in many international guidelines on cancer pain management. The development of sustained-release opioid preparations has made regular dosing easier for patients. However, patients report that the intensity and impact of their cancer pain varies considerably day to day, and many try to find a trade-off between acceptable pain control and impact of cognitive (and other) adverse effects on daily activities. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001755DOI Listing
April 2020
5 Reads

Wnt signaling contributes to withdrawal symptoms from opioid receptor activation induced by morphine exposure or chronic inflammation.

Pain 2020 03;161(3):532-544

SUSTech Center for Pain Medicine and School of Medicine, Southern University of Science and Technology, Shenzhen, China.

Preventing and treating opioid dependence and withdrawal is a major clinical challenge, and the underlying mechanisms of opioid dependence and withdrawal remain elusive. We hypothesized that prolonged morphine exposure or chronic inflammation-induced μ-opioid receptor activity serves as a severe stress that elicits neuronal alterations and recapitulates events during development. Here, we report that Wnt signaling, which is important in developmental processes of the nervous system, plays a critical role in withdrawal symptoms from opioid receptor activation in mice. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001738DOI Listing
March 2020
5.213 Impact Factor

Alterations in pro-nociceptive and anti-nociceptive mechanisms in patients with low back pain: a systematic review with meta-analysis.

Pain 2019 Nov 1. Epub 2019 Nov 1.

Center for Neuroplasticity and Pain (CNAP), SMI®, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.

Altered pro-nociceptive and anti-nociceptive mechanisms are often implicated in painful conditions and have been increasingly studied over the past decade. For some painful conditions alterations are well-established, but in low back pain (LBP) populations there remains considerable debate whether these mechanisms are altered. The present systematic review aimed to address this issue by identifying studies assessing Conditioned Pain Modulation (CPM) and/or Temporal Summation of Pain (TSP) in LBP patients, comparing to either a healthy control group or using a method with reference data available. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001737DOI Listing
November 2019
1 Read

Biomarkers for predicting central neuropathic pain occurrence and severity after spinal cord injury: results of a long-term longitudinal study.

Pain 2020 03;161(3):545-556

Department of Physical Therapy, Sackler Faculty of Medicine, Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.

Central neuropathic pain (CNP) after spinal cord injury (SCI) is debilitating and immensely impacts the individual. Central neuropathic pain is relatively resistant to treatment administered after it develops, perhaps owing to irreversible pathological processes. Although preemptive treatment may overcome this shortcoming, its administration necessitates screening patients with clinically relevant biomarkers that could predict CNP early post-SCI. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001740DOI Listing

Oxaliplatin-induced neuropathy occurs through impairment of haemoglobin proton buffering and is reversed by carbonic anhydrase inhibitors.

Pain 2020 02;161(2):405-415

Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Novara, Italy. Dr. Potenzieri is now with the NBT-Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy.

Oxaliplatin is a cornerstone chemotherapeutic used in the treatment of colorectal cancer, the third leading cause of death in Western countries. Most side effects of this platinum-containing drug are adequately managed in the clinic, although acute and long-term neurotoxicity still severely compromises the quality of life of patients treated with oxaliplatin. We have previously demonstrated that therapeutically relevant concentrations/doses of oxaliplatin lead to a reduction in intracellular pH in mouse dorsal root ganglion (DRG) neurons in vitro and in vivo and that this alteration sensitizes TRPA1 and TRPV1 channels, which most likely mediate the allodynia associated with treatment. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001722DOI Listing
February 2020

Paracetamol is ineffective for acute low back pain even for patients who comply with treatment: complier average causal effect analysis of a randomized controlled trial.

Pain 2019 12;160(12):2848-2854

The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.

In 2014, the Paracetamol for Acute Low Back Pain (PACE) trial demonstrated that paracetamol had no effect compared with placebo in acute low back pain (LBP). However, noncompliance was a potential limitation of this trial. The aim of this study was to investigate the efficacy of paracetamol in acute LBP among compliers. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001685DOI Listing
December 2019
1 Read

Nerve growth factor-mediated photoablation of nociceptors reduces pain behavior in mice.

Pain 2019 10;160(10):2305-2315

European Molecular Biology Laboratory, Italy.

Nerve growth factor (NGF) and its receptors TrkA and p75 play a key role in the development and function of peripheral nociceptive neurons. Here, we describe novel technology to selectively photoablate TrkA-positive nociceptors through delivery of a phototoxic agent coupled to an engineered NGF ligand and subsequent near-infrared illumination. We demonstrate that this approach allows for on demand and localized reversal of pain behaviors in mouse models of acute, inflammatory, neuropathic, and joint pain. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756257PMC
October 2019
3 Reads

Repetitive transcranial magnetic stimulation of the primary motor cortex expedites recovery in the transition from acute to sustained experimental pain: a randomised, controlled study.

Pain 2019 11;160(11):2624-2633

Neuroscience Research Australia, Randwick, New South Wales, Australia.

Repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex (M1) is increasingly being investigated as a means of alleviating chronic pain. However, rTMS interventions are typically initiated once pain has already become chronic and maladaptive patterns of neural activity are likely to have been established. A critical question is whether M1 rTMS applied soon after pain onset can prevent the development of maladaptive neural activity and promote recovery. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001656DOI Listing
November 2019

Pain-related functional interference in patients with chronic neuropathic postsurgical pain: an analysis of registry data.

Pain 2019 08;160(8):1856-1865

Department of Anesthesiology, Ambroise Paré Hospital, Boulogne Billancourt, France.

Although chronic postsurgical pain (CPSP) is a major health care problem, pain-related functional interference has rarely been investigated. Using the PAIN OUT registry, we evaluated patients' pain-related outcomes on the first postoperative day, and their pain-related interference with daily living (Brief Pain Inventory) and neuropathic symptoms (DN4: douleur neuropathique en 4 questions) at 6 months after surgery. Endpoints were pain interference total scores (PITS) and their association with pain and DN4 scores. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001560DOI Listing

Progesterone relates to enhanced incisional acute pain and pinprick hyperalgesia in the luteal phase of female volunteers.

Pain 2019 08;160(8):1781-1793

Department of Anaesthesiology, Intensive Care Medicine, Palliative Care Medicine and Pain Management, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH Bochum, Ruhr University Bochum, Bochum, Germany.

The role of sex hormones on postsurgical pain perception is basically unclear. Here, we studied the role of endogenous gonadal hormones for pain and hyperalgesia in human volunteers after experimental incision. A 4-mm incision was made in the volar forearm of 15 female volunteers both in the follicular and the luteal phase (random block design). Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001561DOI Listing
August 2019
1 Read

Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen.

Pain 2019 08;160(8):1766-1780

Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Australia.

Pain is the leading cause of disability in the developed world but remains a poorly treated condition. Specifically, postsurgical pain continues to be a frequent and undermanaged condition. Here, we investigate the analgesic potential of pharmacological NaV1. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001567DOI Listing
August 2019
2 Reads

Genetic mapping in Diversity Outbred mice identifies a Trpa1 variant influencing late-phase formalin response.

Pain 2019 08;160(8):1740-1753

The Jackson Laboratory, Bar Harbor, ME, United States.

Identification of genetic variants that influence susceptibility to pain is key to identifying molecular mechanisms and targets for effective and safe therapeutic alternatives to opioids. To identify genes and variants associated with persistent pain, we measured late-phase response to formalin injection in 275 male and female Diversity Outbred mice genotyped for over 70,000 single nucleotide polymorphisms. One quantitative trait locus reached genome-wide significance on chromosome 1 with a support interval of 3. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668363PMC
August 2019
2 Reads

Remembering the pain of surgery 1 year later: a longitudinal examination of anxiety in children's pain memory development.

Pain 2019 08;160(8):1729-1739

Department of Psychology, York University, Toronto, ON, Canada.

Children who develop greater negatively-biased recall of pain (ie, recalled pain is higher than the initial pain report) following surgery are at risk for developing chronic pain; therefore, identifying risk factors for the development of biased pain memories is important. Higher anxiety has been implicated in the development of greater negatively-biased recall of pain; however, studies have not examined anxiety at multiple time points before and after a surgery and its relationship to children's postsurgical pain memories after 1 year. This prospective study examined a cohort of 237 children and adolescents undergoing major surgery. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001582DOI Listing
August 2019
5.213 Impact Factor

Cortisol affects pain sensitivity and pain-related emotional learning in experimental visceral but not somatic pain: a randomized controlled study in healthy men and women.

Pain 2019 08;160(8):1719-1728

Institute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Despite growing interest in the role of stress mediators in pain chronicity, the effects of the stress hormone cortisol on acute pain remain incompletely understood. In a randomized, double-blind, placebo-controlled study with N = 100 healthy volunteers, we tested the effects of oral hydrocortisone (20 mg) in 2 widely used pain models for the visceral and somatic modality. Salivary cortisol was increased in the hydrocortisone group (time × group: P < 0. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001579DOI Listing
August 2019
1 Read

Acute neuropathic pain: equivalent or different to chronic neuropathic pain? A call for gathering of scientifically based information on acute neuropathic pain.

Pain 2019 11;160(11):2413-2414

Faculty of Medicine, University of Oslo and Department of Pain Management and Research, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1097/j.pain.0000000000001650DOI Listing
November 2019
2 Reads

Acute alcohol effects on conditioned pain modulation, but not temporal summation of pain.

Pain 2019 09;160(9):2063-2071

Physiological Psychology, Otto-Friedrich University of Bamberg, Bamberg, Germany.

Although pain reduction after alcohol administration has repeatedly been demonstrated, alcohol effects on advanced and clinically relevant dynamic pain paradigms are still unknown. As such, temporal summation of pain (TSP) and conditioned pain modulation (CPM) indicate mechanisms of endogenous pain modulation and involve certain neurotransmitter systems crucially influenced by alcohol. Our study is the first to investigate acute alcohol effects on TSP and CPM. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001597DOI Listing
September 2019

Altered microbiome composition in individuals with fibromyalgia.

Pain 2019 11;160(11):2589-2602

Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, QC, Canada.

Fibromyalgia (FM) is a prevalent syndrome, characterised by chronic widespread pain, fatigue, and impaired sleep, that is challenging to diagnose and difficult to treat. The microbiomes of 77 women with FM and that of 79 control participants were compared using 16S rRNA gene amplification and whole-genome sequencing. When comparing FM patients with unrelated controls using differential abundance analysis, significant differences were revealed in several bacterial taxa. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001640DOI Listing
November 2019
7 Reads

Investigating intraindividual pain variability: methods, applications, issues, and directions.

Pain 2019 11;160(11):2415-2429

Department of Rehabilitation Medicine, University of Washington, Seattle, WA, United States.

Pain is a dynamic experience subject to substantial individual differences. Intensive longitudinal designs best capture the dynamical ebb and flow of the pain experience across time and settings. Thanks to the development of innovative and efficient data collection technologies, conducting an intensive longitudinal pain study has become increasingly feasible. Read More

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http://Insights.ovid.com/crossref?an=00006396-900000000-9867
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http://dx.doi.org/10.1097/j.pain.0000000000001626DOI Listing
November 2019
15 Reads

Pain or nociception? Subjective experience mediates the effects of acute noxious heat on autonomic responses - corrected and republished.

Pain 2019 Jun;160(6):1469-1481

National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD, United States.

Nociception reliably elicits an autonomic nervous system (ANS) response. Because pain and ANS circuitry interact on multiple spinal, subcortical, and cortical levels, it remains unclear whether autonomic responses are simply a reflexive product of noxious stimulation regardless of how stimulation is consciously perceived or whether the experience of pain mediates ANS responses to noxious stimulation. To test these alternative predictions, we examined the relative contribution of noxious stimulation and individual pain experience to ANS responses in healthy volunteers who underwent 1 or 2 pain assessment tasks. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553960PMC
June 2019
3 Reads

What is normal trauma healing and what is complex regional pain syndrome I? An analysis of clinical and experimental biomarkers.

Pain 2019 10;160(10):2278-2289

Department of Anesthesiology, University Hospital of Würzburg, Würzburg, Germany.

Complex regional pain syndrome (CRPS) typically develops after fracture or trauma. Many of the studies so far have analyzed clinical and molecular markers of CRPS in comparison with healthy or pain controls. This approach, however, neglects mechanisms occurring during physiological trauma recovery. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001617DOI Listing
October 2019
13 Reads

Longitudinal translocator protein-18 kDa-positron emission tomography imaging of peripheral and central myeloid cells in a mouse model of complex regional pain syndrome.

Pain 2019 09;160(9):2136-2148

Departments of Anesthesiology, Perioperative and Pain Medicine and.

Complex regional pain syndrome (CRPS) is a severely disabling disease characterized by pain, temperature changes, motor dysfunction, and edema that most often occurs as an atypical response to a minor surgery or fracture. Inflammation involving activation and recruitment of innate immune cells, including both peripheral and central myeloid cells (ie, macrophages and microglia, respectively), is a key feature of CRPS. However, the exact role and time course of these cellular processes relative to the known acute and chronic phases of the disease are not fully understood. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527343PMC
September 2019
20 Reads

Chemotherapy-induced peripheral neuropathy: where are we now?

Authors:
Lesley A Colvin

Pain 2019 05;160 Suppl 1:S1-S10

Chair of Pain Medicine, Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland.

Chemotherapy-induced peripheral neuropathy (CIPN) is a major challenge, with increasing impact as oncological treatments, using potentially neurotoxic chemotherapy, improve cancer cure and survival. Acute CIPN occurs during chemotherapy, sometimes requiring dose reduction or cessation, impacting on survival. Around 30% of patients will still have CIPN a year, or more, after finishing chemotherapy. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499732PMC
May 2019
2 Reads

Hedonic drinking engages a supraspinal inhibition of thermal nociception in adult rats.

Pain 2019 05;160(5):1059-1069

Department of Neurobiology and Physiology, School of Dentistry, Dental Research Institute, Seoul National University, Seoul, Korea.

The taste of sucrose is commonly used to provide pain relief in newborn humans and is innately analgesic to neonatal rodents. In adulthood, sucrose remains a strong motivator to feed, even in potentially hazardous circumstances (ie, threat of tissue damage). However, the neurobiological mechanisms of this endogenous reward-pain interaction are unclear. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001482DOI Listing
May 2019
15 Reads

How are pain and traumatic stress symptoms related in acute whiplash-associated disorders? An investigation of the role of pain-related fear in a daily diary study.

Pain 2019 09;160(9):1954-1966

Recover Injury Research Centre, The University of Queensland, Brisbane, Australia.

Comorbidity of pain and posttraumatic stress disorder is well recognized, but the reason for this association is unclear. This study investigated the direction of the relationship between pain and traumatic stress and the role that pain-related fear plays, for patients with acute whiplash-associated disorder. Participants (n = 99) used an electronic diary to record hourly ratings of pain, traumatic stress, and fear of pain (FOP) symptoms over a day. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001581DOI Listing
September 2019
4 Reads

Platelet-derived growth factor activates nociceptive neurons by inhibiting M-current and contributes to inflammatory pain.

Pain 2019 06;160(6):1281-1296

Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah School of Medicine, Jerusalem, Israel.

Endogenous inflammatory mediators contribute to the pathogenesis of pain by acting on nociceptors, specialized sensory neurons that detect noxious stimuli. Here, we describe a new factor mediating inflammatory pain. We show that platelet-derived growth factor (PDGF)-BB applied in vitro causes repetitive firing of dissociated nociceptor-like rat dorsal root ganglion neurons and decreased their threshold for action potential generation. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553959PMC
June 2019
4 Reads

Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy.

Pain 2019 07;160(7):1644-1661

Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States.

Inhibition of voltage-gated calcium (CaV) channels is a potential therapy for many neurological diseases including chronic pain. Neuronal CaV1/CaV2 channels are composed of α, β, γ and α2δ subunits. The β subunits of CaV channels are cytoplasmic proteins that increase the surface expression of the pore-forming α subunit of CaV. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001524DOI Listing
July 2019
11 Reads
5.213 Impact Factor

Haploinsufficiency of the brain-derived neurotrophic factor gene is associated with reduced pain sensitivity.

Pain 2019 05;160(5):1070-1081

Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health (NIH), Bethesda, MD, United States.

Rare pain-insensitive individuals offer unique insights into how pain circuits function and have led to the development of new strategies for pain control. We investigated pain sensitivity in humans with WAGR (Wilms tumor, aniridia, genitourinary anomaly, and range of intellectual disabilities) syndrome, who have variably sized heterozygous deletion of the 11p13 region. The deletion region can be inclusive or exclusive of the brain-derived neurotrophic factor (BDNF) gene, a crucial trophic factor for nociceptive afferents. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476691PMC
May 2019
19 Reads

Efficacy and safety of loxoprofen sodium topical patch for the treatment of pain in patients with minor acute traumatic limb injuries in Brazil: a randomized, double-blind, noninferiority trial.

Pain 2019 07;160(7):1606-1613

Daiichi Sankyo Brasil, Clinical Research Department, São Paulo, Brazil.

Posttraumatic injury pain is commonly treated with oral nonsteroidal anti-inflammatory drugs. However, oral nonsteroidal anti-inflammatory drugs cause several adverse events, with topical formulations arising as an important alternative. Therefore, we aimed at evaluating the efficacy and safety of loxoprofen patch (LX-P) in the treatment of patients with posttraumatic pain. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001549DOI Listing
July 2019
7 Reads

Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain.

Pain 2019 Apr;160(4):932-944

Alan Edwards Centre for Research on Pain, McGill University, Montre[Combining Acute Accent]al, QC, Canada.

Chronic pain is a debilitating and poorly treated condition whose underlying mechanisms are poorly understood. Nerve injury and inflammation cause alterations in gene expression in tissues associated with pain processing, supporting molecular and cellular mechanisms that maintain painful states. However, it is not known whether transcriptome changes can be used to reconstruct a molecular pathophysiology of pain. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001471DOI Listing
April 2019
22 Reads

The serum protease network-one key to understand complex regional pain syndrome pathophysiology.

Pain 2019 06;160(6):1402-1409

Department of Neurology, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.

Complex regional pain syndrome (CRPS) develops after fracture. The acute CRPS phenotype resembles exaggerated inflammation, which is explained by local and systemic activation of a proinflammatory network including peptides and cytokines. Epidemiologic data suggest that inactivation of the peptidase angiotensin-converting enzyme in patients treated for hypertension increases the odds to develop CRPS. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001503DOI Listing
June 2019
5 Reads

Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain.

Pain 2019 Apr;160(4):824-832

Department of Pharmacology, Arizona Health Sciences Center, University of Arizona, Tucson, AZ, United States.

Chronic pain is associated with neuroplastic changes in the amygdala that may promote hyper-responsiveness to mechanical and thermal stimuli (allodynia and hyperalgesia) and/or enhance emotional and affective consequences of pain. Stress promotes dynorphin-mediated signaling at the kappa opioid receptor (KOR) in the amygdala and mechanical hypersensitivity in rodent models of functional pain. Here, we tested the hypothesis that KOR circuits in the central nucleus of the amygdala (CeA) undergo neuroplasticity in chronic neuropathic pain resulting in increased sensory and affective pain responses. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424634PMC
April 2019
5 Reads

Intact mast cell content during mild head injury is required for development of latent pain sensitization: implications for mechanisms underlying post-traumatic headache.

Authors:
Dara Bree Dan Levy

Pain 2019 05;160(5):1050-1058

Departments of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States.

Post-traumatic headache (PTH) is one of the most common, debilitating, and difficult symptoms to manage after a traumatic head injury. Although the mechanisms underlying PTH remain elusive, recent studies in rodent models suggest the potential involvement of calcitonin gene-related peptide (CGRP), a mediator of neurogenic inflammation, and the ensuing activation of meningeal mast cells (MCs), proalgesic resident immune cells that can lead to the activation of the headache pain pathway. Here, we investigated the relative contribution of MCs to the development of PTH-like pain behaviors in a model of mild closed-head injury (mCHI) in male rats. Read More

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http://Insights.ovid.com/crossref?an=00006396-900000000-9878
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http://dx.doi.org/10.1097/j.pain.0000000000001481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476678PMC
May 2019
4 Reads

The IASP classification of chronic pain for ICD-11: chronic neuropathic pain.

Pain 2019 Jan;160(1):53-59

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

The upcoming 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD) of the World Health Organization (WHO) offers a unique opportunity to improve the representation of painful disorders. For this purpose, the International Association for the Study of Pain (IASP) has convened an interdisciplinary task force of pain specialists. Here, we present the case for a reclassification of nervous system lesions or diseases associated with persistent or recurrent pain for ≥3 months. Read More

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http://Insights.ovid.com/crossref?an=00006396-201901000-0000
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http://dx.doi.org/10.1097/j.pain.0000000000001365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310153PMC
January 2019
70 Reads
5.213 Impact Factor

The IASP classification of chronic pain for ICD-11: chronic postsurgical or posttraumatic pain.

Pain 2019 Jan;160(1):45-52

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Germany.

Chronic pain after tissue trauma is frequent and may have a lasting impact on the functioning and quality of life of the affected person. Despite this, chronic postsurgical and posttraumatic pain is underrecognised and, consequently, undertreated. It is not represented in the current International Classification of Diseases (ICD-10). Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001413DOI Listing
January 2019
5 Reads

Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11).

Pain 2019 Jan;160(1):19-27

The Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.

Chronic pain is a major source of suffering. It interferes with daily functioning and often is accompanied by distress. Yet, in the International Classification of Diseases, chronic pain diagnoses are not represented systematically. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001384DOI Listing
January 2019
37 Reads
5.213 Impact Factor