Search our Database of Scientific Publications and Authors

I’m looking for a

    950 results match your criteria Acute Pain[Journal]

    1 OF 19

    Heterozygous Mutations in Gtp-Cyclohydrolase-1 Reduce Bh4 Biosynthesis but Not Pain Sensitivity.
    Pain 2018 Feb 20. Epub 2018 Feb 20.
    Applied Human Molecular Genetics, Clinical Genetic Clinic, Kennedy Center, Copenhagen University Hospital, Rigshospitalet, Gl. Landevej 7, 2600 Glostrup, Denmark.
    Human studies have demonstrated a correlation between non-coding polymorphisms of 'the pain protective' (PP) haplotype in the GCH1 gene that encodes for GTP cyclohydrolase I (GTPCH1) - which leads to reduced tetrahydrobiopterin (BH4) production in cell systems - and a diminished perception of experimental and clinical pain. Here we investigate whether heterozygous mutations in the GCH1 gene which lead to a profound BH4 reduction in patients with dopa-responsive dystonia (DRD) have any effect on pain sensitivity. The study includes an investigation of GCH1- associated bio-markers and pain sensitivity in a cohort of 22 DRD patients and 36 controls. Read More

    Racial differences in presentations and predictors of acute pain following motor vehicle collision.
    Pain 2018 Feb 9. Epub 2018 Feb 9.
    Anesthesiology, University of North Carolina Chapel Hill.
    African-Americans experience a greater burden of acute pain than non-Hispanic white individuals across of variety of acute medical conditions, but it is unknown if this is the case following trauma. We evaluated pain, pain-related characteristics (e.g. Read More

    Psychological factors predict an unfavorable pain trajectory after hysterectomy: a prospective cohort study on chronic post-surgical pain.
    Pain 2018 Feb 5. Epub 2018 Feb 5.
    Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
    Chronic post-surgical pain (CPSP) is a well-recognized potential complication with negative personal, social and healthcare consequences. However, limited data exists on CPSP and on the course of pain over time after hysterectomy. Using data from a prospective cohort study on a consecutive sample assessed at 4 time points, pre-surgery (T1), 48 hours (T2), 4 months (T3), and 5 years post-surgery (T4), we sought to examine women's post-surgical pain trajectories using assessments of pain at T3 and T4. Read More

    Correlates and importance of neglect-like symptoms in Complex Regional Pain Syndrome.
    Pain 2018 Feb 5. Epub 2018 Feb 5.
    University Medical Center of the Johannes Gutenberg-University Mainz, Department of Neurology Langenbeckstrasse 1, D-55131 Mainz.
    Neglect-like symptoms (NLS) are frequently observed in CRPS. The clinical meaning of NLS, however, is largely unknown. Therefore, this study sets out to assess the importance of NLS for patient outcome and to explore their clinical correlates. Read More

    Spinal PKC/ERK signal pathway mediates hyperalgesia priming.
    Pain 2018 Jan 18. Epub 2018 Jan 18.
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
    Chronic pain can be initiated by one or more acute stimulations to sensitize neurons into the primed state. In the primed state, the basal nociceptive thresholds of the animal are normal, but in response to another hyperalgesic stimulus, the animal develops enhanced and prolonged hyperalgesia. The exact mechanism of how primed state is formed is not completely understood. Read More

    Joint nociceptor nerve activity and pain in an animal model of acute gout and its modulation by intra-articular hyaluronan.
    Pain 2018 Jan 9. Epub 2018 Jan 9.
    Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, Alicante, Spain.
    The mechanisms whereby deposition of monosodium urate (MSU) crystals in gout activates nociceptors to induce joint pain are incompletely understood. We tried to reproduce the signs of painful gouty arthritis, injecting into the knee joint of rats suspensions containing amorphous or triclinic, needle MSU crystals. The magnitude of MSU-induced inflammation and pain behavior signs were correlated with the changes in firing frequency of spontaneous and movement-evoked nerve impulse activity recorded in single knee joint nociceptor saphenous nerve fibers. Read More

    Pain or nociception? Subjective experience mediates the effects of acute noxious heat on autonomic responses.
    Pain 2017 Dec 13. Epub 2017 Dec 13.
    National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD, USA.
    Nociception reliably elicits an autonomic nervous system (ANS) response. Because pain and ANS circuitry interact on multiple spinal, subcortical, and cortical levels, it remains unclear whether autonomic responses are simply a reflexive product of noxious stimulation regardless of how stimulation is consciously perceived or whether the experience of pain mediates ANS responses to noxious stimulation. To test these alternative predictions, we examined the relative contribution of noxious stimulation and individual pain experience to ANS responses in healthy volunteers who underwent 1 or 2 pain assessment tasks. Read More

    Induction of chronic migraine phenotypes in a rat model after environmental irritant exposure.
    Pain 2018 Mar;159(3):540-549
    Departments of Biochemistry and Molecular Biology.
    Air pollution is linked to increased emergency department visits for headache and migraine patients frequently cite chemicals or odors as headache triggers, but the association between air pollutants and headache is not well understood. We previously reported that chronic environmental irritant exposure sensitizes the trigeminovascular system response to nasal administration of environmental irritants. Here, we examine whether chronic environmental irritant exposure induces migraine behavioral phenotypes. Read More

    Tactile acuity (dys)function in acute nociceptive low back pain: a double-blind experiment.
    Pain 2018 Mar;159(3):427-436
    Department of Kinesiotherapy and Special Methods in Physiotherapy, The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland.
    Research shows that chronic pain is related to cortical alterations that can be reflected in reduced tactile acuity, but whether acute pain perception influences tactile acuity has not been tested. Considering the biological role of nociception, it was hypothesized that nociceptive pain will lead to a rapid improvement in tactile acuity and that this effect is correlated with pain intensity and pain distribution. In this randomised double-blind controlled experiment (trial no. Read More

    Clinical trial designs and models for analgesic medications for acute pain in neonates, infants, toddlers, children, and adolescents: ACTTION recommendations.
    Pain 2017 Nov 13. Epub 2017 Nov 13.
    aUniversity of Washington, Seattle, WA, USA bSeattle Children's Hospital, Seattle, WA, USA cCollegium Pharmaceutical, Inc., Canton, MA, USA dHospital for Sick Children, Toronto, ON, Canada eChildren's Hospital of Wisconsin, Milwaukee, WI, USA fPfizer Consumer Healthcare, New York, NY, USA gBoston Children's Hospital, Boston, MA, USA hStanford University School of Medicine, Stanford, CA, USA iStanford Children's Health, Palo alto, CA, USA jJohns Hopkins University Hospital, Baltimore, MA, USA kEmory University, Atlanta, GA USA lUniversity of Rochester, Rochester, NY, USA mQueen's University, Kingston, ON, Canada nChildren's Hospital of Philadelphia, Philadelphia, PA, USA oYale School of Public Health, New Haven, CT, USA.
    Clinical trials to test the safety and efficacy of analgesics across all pediatric age cohorts are needed to avoid inappropriate extrapolation of adult data to children. However, the selection of acute pain models and trial design attributes to maximize assay sensitivity, by pediatric age cohort, remains problematic. Acute pain models used for drug treatment trials in adults are not directly applicable to the pediatric age cohorts - neonates, infants, toddlers, children, and adolescents. Read More

    Nucleus accumbens mediates the pronociceptive effect of sleep deprivation: the role of adenosine A2A and dopamine D2 receptors.
    Pain 2017 Sep 25. Epub 2017 Sep 25.
    Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.
    Sleep disorders increase pain sensitivity and the risk of developing painful conditions; however, the underlying mechanisms are poorly understood. It has been suggested that nucleus accumbens (NAc) influences sleep-wake cycle by means of a balance between adenosine activity at A2A receptors and dopamine activity at D2 receptors. Because the NAc also plays an important role in pain modulation, we hypothesized that the NAc and its A2A and D2 receptors mediate the pronociceptive effect of rapid eye movement (REM) sleep deprivation (SD). Read More

    Photosensitization of TRPA1 and TRPV1 by 7-dehydrocholesterol: implications for the Smith-Lemli-Opitz syndrome.
    Pain 2017 Dec;158(12):2475-2486
    aDepartment of Anatomy, Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania bDepartment of Pharmacology and Clinical Pharmacy, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania cInstitute for Physiology and Pathophysiology, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany dInstitute of Physiology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
    Loss-of-function mutations in the enzyme 7-dehydrocholesterol reductase are responsible for the Smith-Lemli-Opitz syndrome, in which 7-dehydrocholesterol (7-DHC) levels are markedly increased in the plasma and tissues of patients. This increase in 7-DHC is probably associated with the painful and itchy photosensitivity reported by the majority of patients with Smith-Lemli-Opitz syndrome. To identify the molecular targets involved in the activation and photosensitization of primary afferents by 7-DHC, we focused on TRPA1 and TRPV1, two ion channels expressed in nociceptive nerve endings and previously shown to respond to ultraviolet and visible light under pathophysiological circumstances. Read More

    Cannabis constituent synergy in a mouse neuropathic pain model.
    Pain 2017 Dec;158(12):2452-2460
    Pain Management Research Institute, Kolling Institute of Medical Research, Northern Clinical School, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia.
    Cannabis and its psychoactive constituent Δ9-tetrahydrocannabinol (THC) have efficacy against neuropathic pain, however, this is hampered by their side effects. It has been suggested that co-administration with another major constituent cannabidiol (CBD) might enhance the analgesic actions of THC and minimise its deleterious side effects. We examined the basis for this phytocannabinoid interaction in a mouse chronic constriction injury (CCI) model of neuropathic pain. Read More

    Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.
    Pain 2017 Dec;158(12):2442-2451
    Departments of Pharmacology and Anaesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS, Canada.
    Osteoarthritis (OA) is a multifactorial joint disease, which includes joint degeneration, intermittent inflammation, and peripheral neuropathy. Cannabidiol (CBD) is a noneuphoria producing constituent of cannabis that has the potential to relieve pain. The aim of this study was to determine whether CBD is anti-nociceptive in OA, and whether inhibition of inflammation by CBD could prevent the development of OA pain and joint neuropathy. Read More

    Brain processing of the temporal dimension of acute pain in short-term memory.
    Pain 2017 Oct;158(10):2001-2011
    aDepartment of Neuroscience, Université de Montréal, Montréal, QC, CanadabCentre de recherche de l'Institut universitaire de gériatrie de Montréal, Université de Montréal, Montréal, QC, CanadacDepartment of psychology, McGill University, Montreal, QC, CanadadDepartment of Stomatology, Université de Montréal, Montréal, QC, CanadaeÉcole Polytechnique de Montréal, Montréal, QC, CanadafÉcole de psychologie, Université Laval, Quebec City, QC, CanadagGroupe de recherche sur le système nerveux central (GRSNC), and Centre de recherche en neuropsychologie et cognition (CERNEC), Université de Montréal, Montréal, QC, Canada.
    The dynamics of noxious sensation shapes pain perception, yet the memory of the temporal dimension of pain remains almost completely unexplored. Here, brain activity during the memory of pain duration was contrasted with that associated with the memory of pain intensity using functional magnetic resonance imaging and a delayed reproduction task. Participants encoded, maintained during a short delay, and reproduced (1) the "duration" of pain (ie, onset-to-offset), (2) the "dynamics" of pain (ie, evolution of pain over time), or (3) the intensity of pain (ie, control with no explicit temporal processing required). Read More

    Pain and itch outcome trajectories differ among European American and African American survivors of major thermal burn injury.
    Pain 2017 Nov;158(11):2268-2276
    aInstitute for Trauma Recovery, University of North Carolina, Chapel Hill, NC, USA bDepartment of Anesthesiology, University of North Carolina, Chapel Hill, NC, USA cThe Burn Center, Department of Surgery, MedStar Washington Hospital Center, Washington, DC, USA Departments of dMedicine and eBiostatistics, University of North Carolina, Chapel Hill, NC, USA fJaycee Burn Center, University of North Carolina, Chapel Hill, NC, USA gDepartment of Surgery, University of South Florida, Tampa, FL, USA hDepartment of Emergency Medicine, University of North Carolina, Chapel Hill, NC, USA.
    More than half of individuals experiencing major thermal burn injury (MThBI) receive an autologous skin graft (autograft), in which skin is removed from a healthy "donor" site and transplanted to the burn site. Persistent pain and itch at the graft site are major causes of suffering and disability in MThBI survivors. African Americans have a higher risk of MThBI, and in other clinical settings African Americans experience a greater burden of pain and itch relative to European Americans. Read More

    Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development.
    Pain 2017 Nov;158(11):2222-2232
    aSchool of Life Sciences, The University of Nottingham, Nottingham, United Kingdom. Kwok now with the Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada bCentre for Analytical Bioscience, School of Pharmacy, The University of Nottingham, Nottingham, United Kingdom cArthritis Research UK Pain Centre, Nottingham, United Kingdom.
    Significant age- and experience-dependent remodelling of spinal and supraspinal neural networks occur, resulting in altered pain responses in early life. In adults, endogenous opioid peptide and endocannabinoid (ECs) pain control systems exist which modify pain responses, but the role they play in acute responses to pain and postnatal neurodevelopment is unknown. Here, we have studied the changing role of the ECs in the brainstem nuclei essential for the control of nociception from birth to adulthood in both rats and humans. Read More

    Spinal microglia are required for long-term maintenance of neuropathic pain.
    Pain 2017 Sep;158(9):1792-1801
    aThe Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada bDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada cFaculty of Dentistry, McGill University, Montreal, QC, Canada dInstitut universitaire en santé mentale de Québec, QC, Canada eDepartment of Psychiatry and Neuroscience, Université Laval, Québec, QC, Canada.
    While spinal microglia play a role in early stages of neuropathic pain etiology, whether they are useful targets to reverse chronic pain at late stages remains unknown. Here, we show that microglia activation in the spinal cord persists for >3 months following nerve injury in rodents, beyond involvement of proinflammatory cytokine and chemokine signalling. In this chronic phase, selective depletion of spinal microglia in male rats with the targeted immunotoxin Mac1-saporin and blockade of brain-derived neurotrophic factor-TrkB signalling with intrathecal TrkB Fc chimera, but not cytokine inhibition, almost completely reversed pain hypersensitivity. Read More

    Early life vincristine exposure evokes mechanical pain hypersensitivity in the developing rat.
    Pain 2017 Sep;158(9):1647-1655
    aPain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA bDepartments of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
    Vincristine (VNC) is commonly used to treat pediatric cancers, including the most prevalent childhood malignancy, acute lymphoblastic leukemia. Although clinical evidence suggests that VNC causes peripheral neuropathy in children, the degree to which pediatric chemotherapeutic regimens influence pain sensitivity throughout life remains unclear, in part because of the lack of an established animal model of chemotherapy-induced neuropathic pain during early life. Therefore, this study investigated the effects of VNC exposure between postnatal days (P) 11 and 21 on mechanical and thermal pain sensitivity in the developing rat. Read More

    Propranolol treatment prevents chronic central sensitization induced by repeated dural stimulation.
    Pain 2017 Oct;158(10):2025-2034
    aUniversité Clermont AuvergnebInserm, Neuro-Dol, Clermont-Ferrand, FrancecCHU, Clermont-Ferrand, France.
    Migraine is currently conceptualized as a chronic disease with episodic manifestations. In some patients, migraine attack frequency increases, leading to chronic migraine. Daily preventive therapy is initiated to decrease attack frequency. Read More

    Dose-response study of topical allyl isothiocyanate (mustard oil) as a human surrogate model of pain, hyperalgesia, and neurogenic inflammation.
    Pain 2017 Sep;158(9):1723-1732
    Laboratory of Experimental Cutaneous Pain Research, SMI, Department of Health Science and Technology, School of Medicine, Aalborg University, Aalborg, Denmark.
    Despite being a ubiquitous animal pain model, the natural TRPA1-agonist allyl isothiocyanate (AITC, also known as "mustard oil") has only been sparsely investigated as a potential human surrogate model of pain, sensitization, and neurogenic inflammation. Its dose-response as an algogenic, sensitizing irritant remains to be elucidated in human skin. Three concentrations of AITC (10%, 50%, and 90%) and vehicle (paraffin) were applied for 5 minutes to 3 × 3 cm areas on the volar forearms in 14 healthy volunteers, and evoked pain intensity (visual analog scale 0-100 mm) and pain quality were assessed. Read More

    Placebo effects of a sham opioid solution: a randomized controlled study in patients with chronic low back pain.
    Pain 2017 Oct;158(10):1893-1902
    aDepartment of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanybDepartment of Spinal Surgery, Schön Klink Hamburg Eilbek, Hamburg, GermanycDepartment of Orthopedics, University Medical Center Hamburg-Eppendorf, Hamburg, GermanydDepartment of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, GermanyeDepartment of Psychology, University of Mannheim, Mannheim, Germany.
    This study tested the experimental placebo effect in a group of chronic pain patients. Forty-eight patients having chronic back pain participated in a randomized clinical trial that tested the efficacy of a sham opioid solution (NaCl) compared with an alleged neutral, completely inactive solution (NaCl). We shaped the placebo effect by 2 interventions: verbal instruction and conditioning. Read More

    Child and parent pain catastrophizing and pain from presurgery to 6 weeks postsurgery: examination of cross-sectional and longitudinal actor-partner effects.
    Pain 2017 Oct;158(10):1886-1892
    aLawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, CanadabChild Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, CanadacDepartment of Anesthesia, Pain, and Perioperative Medicine, Dalhousie University, Halifax, NS, CanadadCentre for Pediatric Pain Research, IWK Health Centre, Halifax, NS, CanadaeDepartment of Surgery, Dalhousie University, Halifax, NS, Canada.
    Child and parent pain catastrophizing are reported preoperative risk factors for children's acute and persistent postsurgical pain. This study examined dyadic relations between child and parent pain catastrophizing and child and parent ratings of child pain prior to (M = 4.01 days; "baseline") and following surgery (M = 6. Read More

    Mechanisms of distraction in acute pain perception and modulation.
    Pain 2017 06;158(6):1012-1013
    aLawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada, bChild Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada, cDepartment of Psychology and Neuroscience, Dalhousie University, dCentre for Pediatric Pain Research, IWK Health Centre, eDepartment of Pediatrics, IWK Health Centre, Dalhousie University, fThe Mayday Fund.

    Effects of acute psychological stress on placebo and nocebo responses in a clinically relevant model of visceroception.
    Pain 2017 Aug;158(8):1489-1498
    aInstitute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, Essen, GermanybDepartment of Internal Medicine VI, University Hospital Tuebingen, Tuebingen, Germany.
    There is evidence to suggest a role of emotions in placebo and nocebo effects, but whether acute psychological stress changes the magnitude of placebo or nocebo responses has not been tested. In a clinically relevant model of visceroception, we assessed effects of acute psychological stress on changes in urgency and pain in response to positive or negative treatment suggestions. In 120 healthy volunteers, perceived urge-to-defecate and pain in response to individually calibrated rectal distensions were measured with visual analogue scales during a BASELINE. Read More

    Greater fear of visceral pain contributes to differences between visceral and somatic pain in healthy women.
    Pain 2017 Aug;158(8):1599-1608
    aInstitute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Essen, GermanybClinic for Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, GermanycInstitute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
    This functional magnetic resonance imaging study addressed similarities and differences in behavioral and neural responses to experimental visceral compared with somatic pain stimuli and explored the contribution of fear of pain to differences between pain modalities. In N = 22 healthy women, we assessed blood oxygen level-dependent responses to rectal distensions and cutaneous heat stimuli matched for perceived pain intensity. Fear of pain and pain unpleasantness were assessed before and after scanning. Read More

    Neuropathic pain after chronic nerve constriction may not correlate with chloride dysregulation in mouse trigeminal nucleus caudalis neurons.
    Pain 2017 Jul;158(7):1366-1372
    aDepartment of Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA bProgram in Neuroscience, University of Maryland, Baltimore, MD, USA cDepartment of Endodontics, Prosthodontics, and Operative Surgery, Baltimore College of Dentistry, Baltimore, MD, USA.
    Changes in chloride reversal potential in rat spinal cord neurons have previously been associated with persistent pain in nerve injury and inflammation models. These changes correlate with a decrease in the expression of the potassium chloride transporter, KCC2, and with increases in neuronal excitability. Here, we test the hypothesis that similar changes occur in mice with neuropathic pain induced by chronic constriction injury of the trigeminal infraorbital nerve (CCI-ION). Read More

    Targeting brain-derived neurotrophic factor in the medial thalamus for the treatment of central poststroke pain in a rodent model.
    Pain 2017 Jul;158(7):1302-1313
    Neuroscience, Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan.
    Approximately 7% to 10% of patients develop a chronic pain syndrome after stroke. This chronic pain condition is called central poststroke pain (CPSP). Recent studies have observed an abnormal increase in the secretion of brain-derived neurotrophic factor (BDNF) in spinal cord tissue after spinal cord injury. Read More

    Midazolam as an active placebo in 3 fentanyl-validated nociceptive pain models.
    Pain 2017 Jul;158(7):1264-1271
    aDepartment of Anesthesia, General Intensive Care, and Pain Therapy, Medical University of Vienna, Vienna, Austria bDepartment of Anesthesia, Intensive Care, and Pain Medicine, Wilhelminen Hospital, Vienna, Austria cVienna Human Pain Research Group, Vienna, Austria.
    The use of inactive placebos in early translational trials of potentially analgesic compounds is discouraged because of the side-effect profiles of centrally acting analgesics. Therefore, benzodiazepines are used, although their use has not been validated in this context. Whether benzodiazepines confound the results of acute pain tests is unknown. Read More

    Use of analgesics in young adults as a predictor of health care utilization and pain prevalence: Israel defense forces experience.
    Pain 2017 Jun;158(6):1145-1152
    aIsrael Defense Force Medical Corps, Ramat Gan, Israel bDepartment of Management, Bar-Ilan University, Ramat Gan, Israel cDepartment of Neurology, Soroka University Medical Center, Ben Gurion University of the Negev, Beer-Sheva, Israel.
    Pain evaluation in large community studies is difficult. Analgesics can be a useful tool in estimating pain-related conditions in which analgesic use is highly regulated. In this study, we evaluated analgesics consumption patterns of regular Israel Defense Force soldiers. Read More

    Sickle cell disease: a natural model of acute and chronic pain.
    Pain 2017 Apr;158 Suppl 1:S79-S84
    aDepartment of Pediatrics, Section of Pediatric Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI, USA bChildren's Research Institute of the Children's Hospital of Wisconsin, Milwaukee, WI, USA cDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.

    Psychophysical and psychological predictors of acute pain after breast surgery differ in patients with and without pre-existing chronic pain.
    Pain 2017 Jun;158(6):1030-1038
    aDepartment of Neurology, University of Munich, Munich, Germany Departments of bAnaesthesiology, Intensive Care and Pain Medicine and cObstetrics and Gynecology, University Hospital Muenster, Muenster, Germany.
    The prediction of acute postoperative pain would be of great clinical advantage, but results of studies investigating possible predictors are inconsistent. Here, we studied the role of a wide variety of previously suggested predictors in 74 patients undergoing breast surgery. Preoperatively, patients filled out the Pain Sensitivity Questionnaire (PSQ) and a set of psychological questionnaires (the Beck Depression Inventory [BDI], State-Trait Anxiety Inventory [STAI], and Pain Catastrophizing Scale [PCS]) and participated in an experimental pain testing session, including assessment of conditioned pain modulation (CPM), temporal summation, and responses to heat, pinprick, and pressure pain. Read More

    Predictors of the transition from acute to persistent musculoskeletal pain in children and adolescents: a prospective study.
    Pain 2017 May;158(5):794-801
    aDepartment of Pediatrics, Institute on Development and Disability, Oregon Health & Science University, Portland, OR, USA bDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
    Strategies directed at the prevention of disabling pain have been suggested as a public health priority, making early identification of youth at risk for poor outcomes critical. At present, limited information is available to predict which youth presenting with acute pain are at risk for persistence. The aims of this prospective longitudinal study were to identify biopsychosocial factors in the acute period that predict the transition to persistent pain in youth with new-onset musculoskeletal (MSK) pain complaints. Read More

    Burning pain: axonal dysfunction in erythromelalgia.
    Pain 2017 May;158(5):900-911
    aDepartment of Neurology, Sydney Children's Hospital and School of Women's and Children's Health, University of New South Wales, Sydney, Australia bDepartment of Neurology and Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan cBrain and Mind Centre, The University of Sydney, Sydney, Australia dTranslational Neuroscience Facilities (TNF), Department of Physiology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Randwick, Sydney, Australia.
    Erythromelalgia (EM) is a rare neurovascular disorder characterized by intermittent severe burning pain, erythema, and warmth in the extremities on heat stimuli. To investigate the underlying pathophysiology, peripheral axonal excitability studies were performed and changes with heating and therapy explored. Multiple excitability indices (stimulus-response curve, strength-duration time constant (SDTC), threshold electrotonus, and recovery cycle) were investigated in 23 (9 EMSCN9A+ and 14 EMSCN9A-) genetically characterized patients with EM stimulating median motor and sensory axons at the wrist. Read More

    Does expecting more pain make it more intense? Factors associated with the first week pain trajectories after breast cancer surgery.
    Pain 2017 May;158(5):922-930
    aDivision of Pain Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Finland bBreast Surgery Unit, Comprehensive Cancer Center, University of Helsinki and Helsinki University Hospital, Finland cInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland dDepartment of Public Health, Hjelt Institute, University of Helsinki, Finland.
    The aim of this study was to identify clinical risk factors for unfavorable pain trajectories after breast cancer surgery, to better understand the association between pain expectation, psychological distress, and acute postoperative pain. This prospective study included 563 women treated for breast cancer. Psychological data included questionnaires for depressive symptoms and anxiety. Read More

    Long-lasting antinociceptive effects of green light in acute and chronic pain in rats.
    Pain 2017 Feb;158(2):347-360
    Departments of aAnesthesiology andbPharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.
    Treatments for chronic pain are inadequate, and new options are needed. Nonpharmaceutical approaches are especially attractive with many potential advantages including safety. Light therapy has been suggested to be beneficial in certain medical conditions such as depression, but this approach remains to be explored for modulation of pain. Read More

    Persistent pain after motor vehicle collision: comparative effectiveness of opioids vs nonsteroidal antiinflammatory drugs prescribed from the emergency department-a propensity matched analysis.
    Pain 2017 Feb;158(2):289-295
    aDepartment of Emergency Medicine, Alpert Medical School of Brown University, Providence, RI, USA Departments of bEpidemiology and cBiostatistics, Brown University, Providence, RI, USA dDepartment of Quantitative Health Science, University of Massachusetts Medical School, Worcester, MA, USA eDepartment of Emergency Medicine, William Beaumont Hospital, Royal Oak, MI, USA fDepartment of Emergency Medicine, Spectrum Health Butterworth Campus, Grand Rapids, MI, USA gDepartment of Emergency Medicine, North Shore University Hospital, Manhasset, NY, USA hDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA iDepartment of Emergency Medicine, St Joseph Mercy Hospital, Yipsilanti, MI, USA jDepartment of Emergency Medicine, Baystate Medical Center, Springfield, MA, USA Departments of k Emergency Medicine and l Anesthesiology, University of North Carolina, Chapel Hill, NC, USA mTRYUMPH Research Program, University Of North Carolina, Chapel Hill, NC, USA.
    Each year millions of Americans present to the emergency department (ED) for care after a motor vehicle collision (MVC); the majority (>90%) are discharged to home after evaluation. Acute musculoskeletal pain is the norm in this population, and such patients are typically discharged to home with prescriptions for oral opioid analgesics or nonsteroidal antiinflammatory drugs (NSAIDs). The influence of acute pain management on subsequent pain outcomes in this common ED population is unknown. Read More

    Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
    Pain 2017 Mar;158(3):463-470
    aDepartment of Neuroanesthesiology, Rigshospitalet-Glostrup, Copenhagen University Hospital, Glostrup, Denmark bDepartment of Anesthesiology, Nykoebing Falster Hospital, Nykoebing Falster, Denmark, Copenhagen University Hospital cDepartment of Anesthesiology, Aarhus University Hospital, Aarhus, Denmark dDepartment of Anesthesiology, Bispebjerg Hospital, Copenhagen University Hospital, Copenhagen, Denmark eDepartment of Anesthesiology, Zealand University Hospital Koege, Copenhagen University Hospital, Koege, Denmark.
    Perioperative handling of surgical patients with opioid dependency represents an important clinical problem. Animal studies suggest that ketamine attenuates central sensitization and hyperalgesia and thereby reduces postoperative opioid tolerance. We hypothesized that intraoperative ketamine would reduce immediate postoperative opioid consumption compared with placebo in chronic pain patients with opioid dependency undergoing lumbar spinal fusion surgery. Read More

    Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence.
    Pain 2017 Jan;158(1):149-160
    aUniversité Clermont Auvergne, Université d'Auvergne, INSERM UMR 1107 Neuro-Dol Equipe Pharmacologie Fondamentale et Clinique de la Douleur, CHU Clermont-Ferrand Service de Pharmacologie Médicale, Institut Analgesia, Faculté de Médecine, Clermont-Ferrand, France bUniversité Clermont Auvergne, Université d'Auvergne, INSERM UMR 1107 Neuro-Dol Equipe Pharmacologie Fondamentale et Clinique de la Douleur, Institut Analgesia, Faculté de Médecine, Clermont-Ferrand, France cNeuropsychiatry Division, Institut de Recherches Internationales Servier, Suresnes, France.
    Antidepressants are first-line treatments of neuropathic pain but not all these drugs are really effective. Agomelatine is an antidepressant with a novel mode of action, acting as an MT1/MT2 melatonergic receptor agonist and a 5-HT2C receptor antagonist that involves indirect norepinephrine release. Melatonin, serotonin, and norepinephrine have been involved in the pathophysiology of neuropathic pain. Read More

    Genetic variant rs3750625 in the 3'UTR of ADRA2A affects stress-dependent acute pain severity after trauma and alters a microRNA-34a regulatory site.
    Pain 2017 Feb;158(2):230-239
    aTRYUMPH Research Program bDepartment of Anesthesiology, University of North Carolina, Chapel Hill, NC, USA cDepartment of Battlefield Pain Research, Fort Sam, TX, USAISR dForensic Nursing Program, Family Medicine, Cone Health System, Greensboro, NC, USA eDepartment of Emergency Medicine, William Beaumont Hospital, Royal Oak, MI, USA fDepartment of Emergency Medicine, Spectrum Health Butterworth Campus, Grand Rapids, MI, USA gThe Allan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada hDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA iDepartment of Emergency Medicine, University of North Carolina, Chapel Hill, NC, USA.
    α2A adrenergic receptor (α2A-AR) activation has been shown in animal models to play an important role in regulating the balance of acute pain inhibition vs facilitation after both physical and psychological stress. To our knowledge, the influence of genetic variants in the gene encoding α2A-AR, ADRA2A, on acute pain outcomes in humans experiencing traumatic stress has not been assessed. In this study, we tested whether a genetic variant in the 3'UTR of ADRA2A, rs3750625, is associated with acute musculoskeletal pain (MSP) severity following motor vehicle collision (MVC, n = 948) and sexual assault (n = 84), and whether this influence was affected by stress severity. Read More

    Reduced excitability and impaired nociception in peripheral unmyelinated fibers from Nav1.9-null mice.
    Pain 2017 Jan;158(1):58-67
    aInstitute for Physiology and Pathophysiology, University of Erlangen-Nuremberg, Erlangen, Germany bDepartment of Anesthesiology and Operative Intensive Care, Heidelberg University, Mannheim, Germany cDepartment of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.
    The upregulation of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 has previously been associated with inflammatory hyperalgesia. Na1. Read More

    The mitogen and stress-activated protein kinase 1 regulates the rapid epigenetic tagging of dorsal horn neurons and nocifensive behaviour.
    Pain 2016 Nov;157(11):2594-2604
    Department of Cell and Developmental Biology, University College London, London, United Kingdom.
    Phosphorylation of histone H3 at serine 10 (p-H3S10) is a marker of active gene transcription. Using cognitive models of neural plasticity, p-H3S10 was shown to be downstream of extracellular signal-regulated kinase (ERK) signalling in the hippocampus. In this study, we show that nociceptive signalling after peripheral formalin injection increased p-H3S10 expression in the ipsilateral dorsal horn. Read More

    Disproportionate longer-term opioid use among U.S. adults with mood disorders.
    Pain 2016 Nov;157(11):2452-2457
    aDivision of General Medicine and Primary Care, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA bDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
    Adults with mood disorders frequently use prescription opioids. The factors associated with this increased use remain unclear. We used the Medical Expenditure Panel Surveys from 2005 to 2011 to measure the association of mood disorders with new opioid use and the transition to longer-term opioid use for a variety of pain conditions before and after controlling for patient characteristics and clinical disability. Read More

    Differential expression of systemic inflammatory mediators in amputees with chronic residual limb pain.
    Pain 2017 Jan;158(1):68-74
    Departments of aPharmacology and Cancer Biology and bAnesthesiology, Duke University Medical Center, Durham, NC cDivision of Anesthesiology, Durham Veterans Affairs Medical Center, Durham, NC dDefense and Veterans Center for Integrative Pain Management, Rockville, MD eDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN Departments of fBiomedical Informatics, gMedicine, and hAnesthesiology, Vanderbilt University Medical Center, Nashville, TN iDepartment of Military Emergency Medicine, Uniformed Services University, Bethesda, MD.
    Chronic postsurgical pain impacts most amputees, with more than half experiencing neuralgic residual limb pain. The transition from normal acute postamputation pain to chronic residual limb pain likely involves both peripheral and central inflammatory mechanisms. As part of the Veterans Integrated Pain Evaluation Research study, we investigated links between systemic inflammatory mediator levels and chronic residual limb pain. Read More

    Hedonic and motivational responses to food reward are unchanged in rats with neuropathic pain.
    Pain 2016 Dec;157(12):2731-2738
    aDepartment of Pharmacology, University of Arizona, Tucson, AZ, USA bNeuroscience Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN, USA cDepartment of Psychology, University of Arizona, Tucson, AZ, USA.
    Rewards influence responses to acute painful stimuli, but the relationship of chronic pain to hedonic or motivational aspects of reward is not well understood. We independently evaluated hedonic qualities of sweet or bitter tastants and motivation to seek food reward in rats with experimental neuropathic pain induced by L5/6 spinal nerve ligation. Hedonic response was measured by implantation of intraoral catheters to allow passive delivery of liquid solutions, and "liking/disliking" responses were scored according to a facial reactivity scale. Read More

    Angiotensin-(1-7)/Mas receptor as an antinociceptive agent in cancer-induced bone pain.
    Pain 2016 Dec;157(12):2709-2721
    aDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA bDepartment of Physiology, Evelyn McKnight Brain Institute, College of Medicine, University of Arizona, Tucson, AZ, USA.
    Many cancerous solid tumors metastasize to the bone and induce pain (cancer-induced bone pain [CIBP]). Cancer-induced bone pain is often severe because of enhanced inflammation, rapid bone degradation, and disease progression. Opioids are prescribed to manage this pain, but they may enhance bone loss and increase tumor proliferation, further compromising patient quality of life. Read More

    The effect of pain on task switching: pain reduces accuracy and increases reaction times across multiple switching paradigms.
    Pain 2016 Oct;157(10):2179-93
    aMathematics Education Centre, School of Science, Loughborough University, Loughborough, United Kingdom, bCentre for Pain Research, University of Bath, Bath, United Kingdom.
    Pain disrupts attention, which may have negative consequences for daily life for people with acute or chronic pain. It has been suggested that switching between tasks may leave us particularly susceptible to pain-related attentional disruption, because we need to disengage our attention from one task before shifting it onto another. Switching tasks typically elicit lower accuracies and/or longer reaction times when participants switch to a new task compared with repeating the same task, and pain may exacerbate this effect. Read More

    1 OF 19