13,744 results match your criteria Acute Myocardial Infarct Imaging


Description of chest pain patients in a Norwegian emergency department.

Scand Cardiovasc J 2019 Feb 14:1-21. Epub 2019 Feb 14.

b Department of Circulation and Medical Imaging , Norwegian University of Science and Technology , Trondheim , Norway.

Objectives: Chest pain is one of the most frequent chief complaints in patients admitted to the emergency department (ED). No study has evaluated this patient population in Norway. The aim of the present study was to describe the diagnoses and logistics of chest pain patients admitted to the ED at a Norwegian university hospital. Read More

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http://dx.doi.org/10.1080/14017431.2019.1583362DOI Listing
February 2019

Clinical manifestations, diagnosis, and treatment of ischemic mitral regurgitation: a review.

J Thorac Dis 2018 Dec;10(12):6969-6986

Department of Cardiology, Hospital Universitario de Canarias, Tenerife, Spain.

Ischemic mitral regurgitation (IMR) is a frequent complication after acute myocardial infarction (AMI) associated with a worse prognosis. The pathophysiological mechanisms of IMR are not fully understood, but it is known to be a complex process in which ventricular remodelling is the main causal factor. The various imaging techniques in cardiology and echocardiography fundamentally have contributed significantly to clarify the mechanisms that cause and progressively aggravate IMR. Read More

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http://jtd.amegroups.com/article/view/25085/19483
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http://dx.doi.org/10.21037/jtd.2018.10.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344722PMC
December 2018
2 Reads

Spherical Nucleic Acid Enzyme (SNAzyme) Boosted Chemiluminescence miRNA Imaging Using a Smartphone.

Anal Chem 2019 Feb 14. Epub 2019 Feb 14.

Department of Chemistry , University of Science & Technology of China , Hefei , Anhui 230026 , China.

As acute myocardial infarction (AMI) has now become a severe death threat to humans and may abruptly occur at home or outdoors where sophisticated equipment is not available, it is of great importance to develop facile methodologies for the point-of-care (POC) diagnosis of AMI. Toward this goal, here we build a sensing platform for chemiluminescence (CL) microRNA (miRNA) imaging with a smartphone as the portable detector, and for the first time we achieve visualization of AMI-related miRNAs in real patients' serum. We first construct a spherical nucleic acid enzyme (termed SNAzyme) derived from a dense layer of G-quadruplex (G4) DNAzyme formed on the gold nanoparticle core, which displays ∼100-fold and higher catalytic activity and improved resistance to nuclease degradation in a real blood sample as compared to those of the G4 DNAzyme itself. Read More

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http://pubs.acs.org/doi/10.1021/acs.analchem.8b05696
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http://dx.doi.org/10.1021/acs.analchem.8b05696DOI Listing
February 2019
3 Reads

Decellularized neonatal cardiac extracellular matrix prevents widespread ventricular remodeling in adult mammals after myocardial infarction.

Acta Biomater 2019 Jan 30. Epub 2019 Jan 30.

Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA 15261, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh and UPMC, Pittsburgh, PA 15260, USA. Electronic address:

Heart disease remains a leading killer in western society and irreversibly impacts the lives of millions of patients annually. While adult mammals do not possess the ability to regenerate functional cardiac tissue, neonatal mammals are capable of robust cardiomyocyte proliferation and regeneration within a week of birth. Given this change in regenerative function through development, the extracellular matrix (ECM) from adult tissues may not be conducive to promoting cardiac regeneration, although conventional ECM therapies rely exclusively on adult-derived tissues. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.062DOI Listing
January 2019
1 Read

Water-fat separation and parameter mapping in cardiac MRI via deep learning with a convolutional neural network.

J Magn Reson Imaging 2019 Jan 30. Epub 2019 Jan 30.

Department of Research and Education, Saint Francis Hospital, Roslyn, New York, USA.

Background: Water-fat separation is a postprocessing technique most commonly applied to multiple-gradient-echo magnetic resonance (MR) images to identify fat, provide images with fat suppression, and to measure fat tissue concentration. Recently, Numerous advancements have been reported. In contrast to early methods, the process of water-fat separation has become complicated due to multiparametric analytic models, optimization methods, and the absence of a unified framework for diverse source data. Read More

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http://doi.wiley.com/10.1002/jmri.26658
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http://dx.doi.org/10.1002/jmri.26658DOI Listing
January 2019
2 Reads

Vascular response and intrastent thrombus in the early phase after drug-eluting versus bare-metal stent implantation in patients with ST-segment elevation myocardial infarction: An observational, single-center study.

Health Sci Rep 2019 Jan 5;2(1):e105. Epub 2018 Dec 5.

Department of Cardiovascular Medicine Kitasato University Hospital Sagamihara Japan.

Background And Objectives: Second-generation drug-eluting stents (G2-DES) are associated with a lower rate of acute and subacute stent thrombosis compared with bare-metal stent (BMS) in the setting of ST-segment elevation myocardial infarction (STEMI). In this study, our aim was to compare the vascular response and thrombus burden between G2-DES and BMS in early-phase STEMI.

Methods: Between May 2010 and August 2014, a total of 41 STEMI patients treated by either G2-DES (n = 26; everolimus-eluting stent [EES]: n = 15, zotarolimus-eluting stent [ZES]: n = 11) or BMS (n = 15) and, with multivessel disease requiring additional percutaneous coronary intervention (PCI), were prospectively enrolled. Read More

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http://dx.doi.org/10.1002/hsr2.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346990PMC
January 2019

D-dimer/troponin ratio in the differential diagnosis of acute pulmonary embolism from non-ST elevation myocardial infarction.

Korean J Intern Med 2019 Jan 28. Epub 2019 Jan 28.

Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea.

Background/aims: The aim of this study was to investigate useful cardiac biomarkers in the differential diagnosis of acute pulmonary embolism (APE) with troponin elevation from acute non-ST elevation myocardial infarction (NSTEMI).

Methods: A total of 771 consecutive NSTEMI patients with D-dimer measurements and 90 patients with troponin-I (TnI) elevation out of 233 APE patients were enrolled, and cardiac biomarkers were compared.

Results: D-dimer elevation was noted in 382 patients with NSTEMI (49. Read More

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http://dx.doi.org/10.3904/kjim.2018.153DOI Listing
January 2019

Single-Molecule hsTnI and Short-Term Risk in Stable Patients With Chest Pain.

J Am Coll Cardiol 2019 Jan;73(3):251-260

Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina; Department of Medicine, Duke University School of Medicine, Durham, North Carolina.

Background: Evaluation of stable symptomatic outpatients with suspected coronary artery disease (CAD) may be challenging because they have a wide range of cardiovascular risk. The role of troponin testing to assist clinical decision making in this setting is unexplored.

Objectives: This study sought to evaluate the prognostic meaning of single-molecule counting high-sensitivity troponin I (hsTnI) (normal range <6 ng/l) among outpatients with stable chest symptoms and suspected CAD. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.10.065DOI Listing
January 2019

Myocardial Blood Flow as a Holistic Metric for Predicting Remodeling and Clinical Outcomes After a Myocardial Infarction?

JACC Cardiovasc Imaging 2019 Jan 9. Epub 2019 Jan 9.

School of Bioengineer and Medical Sciences, Life Sciences, King's College London, United Kingdom; Department of Imaging and Pathology KU Leuven, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jcmg.2018.11.013DOI Listing
January 2019

Acute Microvascular Impairment Post-Reperfused STEMI Is Reversible and Has Additional Clinical Predictive Value: A CMR OxAMI Study.

JACC Cardiovasc Imaging 2019 Jan 9. Epub 2019 Jan 9.

Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom. Electronic address:

Objectives: This study sought to investigate the clinical utility and the predictive relevance of absolute rest myocardial blood flow (MBF) by cardiac magnetic resonance (CMR) in acute myocardial infarction.

Background: Microvascular obstruction (MVO) remains one of the worst prognostic factors in patients with reperfused ST-segment elevation myocardial infarction (STEMI). Clinical trials have focused on cardioprotective strategies to maintain microvascular functionality, but there is a need for a noninvasive test to determine their efficacy. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.10.028DOI Listing
January 2019

Delayed-enhancement 320 row volume multidetector computed tomography for the assessment of reperfused acute and old myocardial infarction in a porcine model.

J Biol Regul Homeost Agents 2019 01 18;33(1). Epub 2019 Jan 18.

Department of Cardiology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.

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January 2019

Evaluation of myocardial viability in patients with acute myocardial infarction: Layer-specific analysis of 2-dimensional speckle tracking echocardiography.

Medicine (Baltimore) 2019 Jan;98(3):e13959

Institute of Cardiovascular Disease, Xuzhou Medical University, Xuzhou 221002, Jiangsu Province.

Background: The value of layer-specific two-dimensional speckle tracking echocardiography (LS2D-STE) for evaluating viable myocardium (VM) in patients with acute myocardial infarction (AMI) was unclear, this study provides new insights into it and to make a comparison with dualisotope simultaneous acquisition single photon emission computed tomography ( DISA-SPECT).

Methods: Forty hospitalized patients with AMI and left ventricular systolic dysfunction (left ventricular ejection fraction <50%) underwent LS2D-STE and DISA-SPECT before percutaneous coronary intervention (PCI). The longitudinal, circumferential, and radial peak systolic strains and the peak systolic strain rates of 3 myocardiallayers (endocardium, mid-myocardium, and epicardium), as well as the total wall thickness, were determined by LS2D-STE. Read More

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http://dx.doi.org/10.1097/MD.0000000000013959DOI Listing
January 2019
1 Read

Transcriptional Alterations by Ischaemic Postconditioning in a Pig Infarction Model: Impact on Microvascular Protection.

Int J Mol Sci 2019 Jan 15;20(2). Epub 2019 Jan 15.

Department of Cardiology, Medical University of Vienna, A-1090 Vienna, Austria.

Although the application of cardioprotective ischaemia/reperfusion (I/R) stimuli after myocardial infarction (MI) is a promising concept for salvaging the myocardium, translation to a clinical scenario has not fulfilled expectations. We have previously shown that in pigs, ischaemic postconditioning (IPostC) reduces myocardial oedema and microvascular obstruction (MVO), without influencing myocardial infarct size. In the present study, we analyzed the mechanisms underlying the IPostC-induced microvascular protection by transcriptomic analysis, followed by pathway analysis. Read More

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http://www.mdpi.com/1422-0067/20/2/344
Publisher Site
http://dx.doi.org/10.3390/ijms20020344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358966PMC
January 2019
4 Reads

Gelatin Based Polymer Cell Coating Improves Bone Marrow-Derived Cell Retention in the Heart after Myocardial Infarction.

Stem Cell Rev 2019 Jan 15. Epub 2019 Jan 15.

Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA.

Background: Acute myocardial infarction (AMI) and the ensuing ischemic heart disease are approaching an epidemic state. Limited stem cell retention following intracoronary administration has reduced the clinical efficacy of this novel therapy. Polymer based cell coating is biocompatible and has been shown to be safe. Read More

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http://link.springer.com/10.1007/s12015-018-9870-5
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http://dx.doi.org/10.1007/s12015-018-9870-5DOI Listing
January 2019
10 Reads

Size of Anterior Wall Acute Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention in United States Versus Europe/Australia Versus India (from the CRISP-AMI Randomized Controlled Trial).

Am J Cardiol 2019 Jan 4. Epub 2019 Jan 4.

Duke Clinical Research Institute, Durham, North Carolina; Duke University Medical Center, Durham, North Carolina. Electronic address:

International variability in infarct size following acute anterior ST-elevation myocardial infarction without shock treated with primary percutaneous coronary intervention (PCI) has been little studied. Patients enrolled in the Counterpulsation to Reduce Infarct Size pre-PCI for Acute Myocardial Infarction international randomized trial were analyzed according to their region of enrollment: United States (US) (n = 60), Europe/Australia (EU/AU) (n = 104), or India (n = 123). Cardiac magnetic resonance imaging was performed 3-5 days after PCI to assess infarct size, expressed as percentage of left ventricular mass, and analyzed by an imaging core laboratory. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149193003
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http://dx.doi.org/10.1016/j.amjcard.2018.12.027DOI Listing
January 2019
6 Reads

Exercise training for patients with type 2 diabetes and cardiovascular disease: What to pursue and how to do it. A Position Paper of the European Association of Preventive Cardiology (EAPC).

Eur J Prev Cardiol 2019 Jan 14:2047487318820420. Epub 2019 Jan 14.

17 University Cardiology Department and Heart Failure Unit and Cardiopulmonary Laboratory, Cardiology, I.R.C.C.S., Milan, Italy.

Patients with type 2 diabetes mellitus suffer from dysregulation of a plethora of cardiovascular and metabolic functions, including dysglycaemia, dyslipidaemia, arterial hypertension, obesity and a reduced cardiorespiratory fitness. Exercise training has the potential to improve many of these functions, such as insulin sensitivity, lipid profile, vascular reactivity and cardiorespiratory fitness, particularly in type 2 diabetes mellitus patients with cardiovascular comorbidities, such as patients that suffered from an acute myocardial infarction, or after a coronary intervention such as percutaneous coronary intervention or coronary artery bypass grafting. The present position paper aims to provide recommendations for prescription of exercise training in patients with both type 2 diabetes mellitus and cardiovascular disease. Read More

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http://journals.sagepub.com/doi/10.1177/2047487318820420
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http://dx.doi.org/10.1177/2047487318820420DOI Listing
January 2019
16 Reads

State of the art: Evaluation and prognostication of myocarditis using cardiac MRI.

J Magn Reson Imaging 2019 Jan 13. Epub 2019 Jan 13.

Department of Cardiology, Barbara and Donald Zucker School of Medicine at Hofstra Northwell, Manhasset, New York, USA.

Myocarditis encompasses both primary and secondary processes causing inflammation of the myocardium. Viral infections are a common secondary cause of myocarditis with important clinical relevance. Viral myocarditis has a varied clinical presentation, potentially resulting in significant morbidity and mortality. Read More

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http://dx.doi.org/10.1002/jmri.26611DOI Listing
January 2019
1 Read

A case report of spontaneous coronary artery dissection and the role of intravascular imaging for accurate diagnosis and successful management.

Medicine (Baltimore) 2019 Jan;98(2):e14112

Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital.

Rationale: Acute myocardial infarction (AMI) secondary to spontaneous coronary artery dissection (SCAD) is a rare condition. SCAD can be underdiagnosed on a coronary angiography (CAG). Therefore, the application of intravascular imaging including intravascular ultrasound (IVUS) and optical coherence tomography (OCT) is crucial for ensuring an accurate diagnosis and treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000014112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336604PMC
January 2019

Elevated renalase levels in patients with acute coronary microvascular dysfunction - A possible biomarker for ischemia.

Int J Cardiol 2019 Mar 2;279:155-161. Epub 2019 Jan 2.

Department of Internal Medicine (Section of Nephrology), New Haven, CT, United States of America.

Aims: We explored the relationship between inflammation, renalase an anti-inflammatory protein, and acute chest pain with coronary microvascular dysfunction (CMD).

Methods And Results: We used cardiac Rb-82 PET/CT imaging to diagnose coronary artery disease (CAD/CALC) (defect or coronary calcification) and CMD (depressed coronary flow reserve without CAD) in patients with chest pain in an emergency department (ED). Blood samples were collected pre-imaging within 24 h of ED presentation and were analyzed for renalase and inflammatory markers including C-reactive protein, interleukins, interferon gamma, tumor necrosis factor, vascular endothelial growth factor, and metalloproteinases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01675273183669
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http://dx.doi.org/10.1016/j.ijcard.2018.12.061DOI Listing
March 2019
5 Reads

In-stent Massive Thrombi Formation During Primary Percutaneous Coronary Intervention in a Patient with Acute Myocardial Infarction Complicated with Essential Thrombocythemia.

Intern Med 2019 Jan 10. Epub 2019 Jan 10.

Department of Cardiology, Japanese Red Cross Kyoto Daiichi Hospital, Japan.

A 61-year-old man with essential thrombocythemia (ET) presented with acute myocardial infarction (AMI) and underwent primary percutaneous coronary intervention. After stent deployment from the left main (LM) to the left anterior descending artery, intravascular ultrasound revealed thrombi formation in the whole stent. Two days later, optical frequency domain imaging confirmed stent malapposition and thrombi remaining in only the LM. Read More

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http://dx.doi.org/10.2169/internalmedicine.2083-18DOI Listing
January 2019
1 Read

Predicting Acute Myocardial Infarction with a Single Blood Draw.

Clin Chem 2019 Jan 9. Epub 2019 Jan 9.

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland;

Background: We desired to determine cardiac troponin (cTn) concentrations necessary to achieve a positive predictive value (PPV) of ≥75% for acute myocardial infarction (AMI) to justify immediate admission of patients to a monitored unit and, in general, early coronary angiography.

Methods: In a prospective multicenter diagnostic study enrolling patients presenting to the emergency department with symptoms suggestive of AMI, final diagnoses were adjudicated by 2 independent cardiologists based on clinical information including cardiac imaging. cTn concentrations were measured using 5 different sensitive and high-sensitivity cTn (hs-cTn) assays in a blinded fashion at presentation and serially thereafter. Read More

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http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.294
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http://dx.doi.org/10.1373/clinchem.2018.294124DOI Listing
January 2019
6 Reads

Effect of Low-Dose Intracoronary Alteplase During Primary Percutaneous Coronary Intervention on Microvascular Obstruction in Patients With Acute Myocardial Infarction: A Randomized Clinical Trial.

JAMA 2019 01;321(1):56-68

British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.

Importance: Microvascular obstruction commonly affects patients with acute ST-segment elevation myocardial infarction (STEMI) and is associated with adverse outcomes.

Objective: To determine whether a therapeutic strategy involving low-dose intracoronary fibrinolytic therapy with alteplase infused early after coronary reperfusion will reduce microvascular obstruction.

Design, Setting, And Participants: Between March 17, 2016, and December 21, 2017, 440 patients presenting at 11 hospitals in the United Kingdom within 6 hours of STEMI due to a proximal-mid-vessel occlusion of a major coronary artery were randomized in a 1:1:1 dose-ranging trial design. Read More

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2018.19802DOI Listing
January 2019
9 Reads

mi R -15a/15b Cluster Modulates Survival of Mesenchymal Stem Cells to Improve Its Therapeutic Efficacy of Myocardial Infarction.

J Am Heart Assoc 2019 Jan;8(1):e010157

1 Department of Cardiology The 2nd Hospital of Harbin Medical University Nangang District Harbin China.

Background The poor viability of transplanted mesenchymal stem cells (MSCs) hampers their therapeutic efficacy for ischemic heart disease. Micro RNA s are involved in regulation of MSC survival and function. The present study was designed to investigate the molecular effects of mi R -15a/15b on MSC survival, focusing on the role of vascular endothelial growth factor receptor 2. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.010157
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http://dx.doi.org/10.1161/JAHA.118.010157DOI Listing
January 2019
6 Reads

Studies Targeting Stroke and Acute Myocardial Infarction.

Ther Hypothermia Temp Manag 2019 Jan 7. Epub 2019 Jan 7.

4 Center for Intensive Internal Medicine, University Medical Center, Ljubljana, Slovenia.

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http://dx.doi.org/10.1089/ther.2018.29054.mckDOI Listing
January 2019

Disparate impact of ischemic injury on regional wall dysfunction in acute anterior vs inferior myocardial infarction.

Cardiovasc Revasc Med 2018 Dec 21. Epub 2018 Dec 21.

Department of Cardiovascular Medicine, Beaumont Hospital Royal Oak, MI, USA.

Background: Acute transmural ischemia should induce similar magnitude of wall motion abnormality (WMA) in both anterior myocardial infarction (AMI) and inferior (IMI). However, patients with AMI generally suffer more severe hemodynamic compromise.

Methods: This retrospective study compared WMA's in ST segment elevation MI patients undergoing primary reperfusion and subsequent cardiac MRI. Read More

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http://dx.doi.org/10.1016/j.carrev.2018.12.016DOI Listing
December 2018
2 Reads

Feasibility of simultaneous Tc-tetrofosmin and I-BMIPP dual-tracer imaging with cadmium-zinc-telluride detectors in patients undergoing primary coronary intervention for acute myocardial infarction.

J Nucl Cardiol 2019 Jan 2. Epub 2019 Jan 2.

Division of Nuclear Medicine, Department of Radiology, Saitama Medical University, Saitama, Japan.

Background: Simultaneous dual-tracer imaging using isotopes with close photo-peaks may benefit from improved properties of cadmium-zinc-telluride (CZT)-based scanners.

Methods: Thirty patients having undergone primary percutaneous coronary intervention for acute myocardial infarction underwent single-(Tc-tetrofosmin (TF) or I-BMIPP first) followed by simultaneous Tc-TF /I-BMIPP dual-tracer imaging using a Discovery NM/CT 670 CZT. The values for the quantitative gated-SPECT (QGS) and the quantitative perfusion SPECT (QPS) were assessed. Read More

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http://dx.doi.org/10.1007/s12350-018-01585-9DOI Listing
January 2019
1 Read

Left ventricular reverse remodeling in patients with anterior wall ST-segment elevation acute myocardial infarction treated with primary percutaneous coronary intervention.

Postepy Kardiol Interwencyjnej 2018 11;14(4):373-382. Epub 2018 Dec 11.

1 Department of Cardiology, Upper Silesian Medical Centre, Katowice, Poland.

Introduction: The study aimed to evaluate the prevalence and predictors of left ventricular (LV) reverse remodeling and its impact on long-term prognosis in patients with anterior ST-segment elevation myocardial infarction (STEMI).

Aim: To assess the percentage of reverse remodeling and its prognostic factors in anterior STEMI patients.

Material And Methods: This observational study included 40 patients with first ever STEMI of the anterior wall. Read More

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http://dx.doi.org/10.5114/aic.2018.79867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309837PMC
December 2018
1 Read

Baseline Troponin T level in stroke and its association with stress cardiomyopathy.

PLoS One 2018 31;13(12):e0209764. Epub 2018 Dec 31.

Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Background: Differential diagnosis of elevated high sensitive Troponin T (hsTnT) in acute ischemic stroke includes myocardial infarction (MI) and neurogenic stunned myocardium (NSM). The aim of this study was to identify factors associated with baseline hsTnT levels and MI or NSM in acute ischemic stroke.

Methods: We studied 204 consecutive patients of the prospective acquired Bern Stroke Database with acute ischemic stroke diagnosed by brain MR. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209764PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312325PMC
December 2018

Diagnostic accuracy of a novel 'winking coronary angiographic sign' in patients presenting with ventricular septal rupture complicating acute myocardial infarction.

Indian Heart J 2018 Dec 10;70 Suppl 3:S403-S405. Epub 2018 Nov 10.

Department of Cardiology, U.N.Mehta Institute of Cardiology and Research Centre (UNMICRC), Asarwa, Ahmedabad, 380016, India.

Ventricular septal rupture (VSR) is an uncommon but potentially lethal complication of acute myocardial infarction (MI). Its prompt recognition is essential to permit timely institution of corrective measures. The present study was undertaken to assess the diagnostic accuracy of a novel and unique angiographic sign, the 'winking coronary sign (WCS)', for recognizing post-MI VSR. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310177PMC
December 2018
3 Reads

Clinical, demographic, risk factor and angiographic profile of coronary slow flow phenomenon: A single centre experience.

Indian Heart J 2018 Dec 5;70 Suppl 3:S290-S294. Epub 2018 Jun 5.

Department of Cardiology, DR. S.N. Medical College, Jodhpur, India.

Background: The coronary slow flow phenomenon (CSFP) is an angiographic finding characterized by delayed distal vessel opacification in the absence of significant epicardial coronary stenosis. Although it is well-known to interventional cardiologists for approximately four decades, the etiopathogenesis still remains unclear.

Aims And Objectives: In this study, we aimed to determine the clinical, demographic, risk factor and angiographic profile of patients with CSFP. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310702PMC
December 2018

Prognostic significance of fragmented QRS in patients with ST-elevation myocardial infarction undergoing revascularization.

Indian Heart J 2018 Dec 17;70 Suppl 3:S126-S132. Epub 2018 Aug 17.

Department of Cardiology, AIIMS, New Delhi, India.

Background & Objectives: This longitudinal study was carried out to evaluate the prognostic significance of fragmented QRS (fQRS) in patients with acute ST elevation myocardial infarction (STEMI) undergoing revascularization.

Methods: This study included 103 STEMI patients belonging to Killip class I and II who underwent primary revascularization. All patients underwent twelve lead ECG at admission before PCI. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309576PMC
December 2018
1 Read

Myocardial Partition Coefficient of Gadolinium: A Pilot Study in Patients With Acute Myocarditis, Chronic Myocardial Infarction, and in Healthy Volunteers.

Can J Cardiol 2019 Jan 16;35(1):51-60. Epub 2018 Oct 16.

Philippa & Marvin Carsley CMR Center, Montréal Heart Institute, Université de Montréal, Montréal, Québec, Canada. Electronic address:

Background: The tissue-blood partition coefficient (PC) of gadolinium, derived from T1 measurements, reflects myocardial connective tissue fraction and tissue injury, increasing in proportion with edema or fibrosis. We determined the myocardial PC of gadolinium in patients with acute myocarditis, chronic myocardial infarction (MI), and healthy volunteers. We hypothesized that the characteristics of the injured myocardium in patients with MI and myocarditis may differ and that the PC will be higher in chronically injured myocardium (MI) compared with acutely injured myocardium (myocarditis). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X183122
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http://dx.doi.org/10.1016/j.cjca.2018.10.005DOI Listing
January 2019
3 Reads

Speckle tracking imaging as a predictor of left ventricular remodeling 6 months after first anterior ST elevation myocardial infarction in patients managed by primary percutaneous coronary intervention.

Egypt Heart J 2018 Dec 17;70(4):343-352. Epub 2018 Jul 17.

Cardiology Department, Ain Shams University Hospital, Cairo, Egypt.

Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. LV remodeling is an important factor in the pathophysiology of advancing heart failure (HF).

Aim Of The Work: To evaluate the value of speckle tracking imaging as a predictor of left ventricular remodeling 6 months after first anterior STEMI in patients managed by primary PCI. Read More

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http://dx.doi.org/10.1016/j.ehj.2018.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303382PMC
December 2018
1 Read

Myocardial and Systemic Inflammation in Acute Stress-Induced (Takotsubo) Cardiomyopathy.

Circulation 2018 Nov 11. Epub 2018 Nov 11.

Aberdeen Cardiovascular and Diabetes Centre, University of Aberdeen, United Kingdom.

Background: Acute stress induced (takotsubo) cardiomyopathy can result in a heart failure phenotype with a prognosis comparable to myocardial infarction. In this study, we hypothesized that inflammation is central to the pathophysiology and natural history of takotsubo cardiomyopathy.

Methods: In a multi-centre study, we prospectively recruited 55 patients with takotsubo cardiomyopathy and 51 age, sex and co-morbidity matched control subjects. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037975DOI Listing
November 2018
1 Read

Evaluation of Microvascular Injury in Revascularized Patients With ST-Segment-Elevation Myocardial Infarction Treated With Ticagrelor Versus Prasugrel.

Circulation 2019 Jan;139(5):636-646

Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands (M.A.H.v.L., N.W.v.d.H., G.N.J., H.E., A.N., J.S.L., G.A.d.W., A.C.v.R., R.N., N.v.R.).

Background: Despite successful restoration of epicardial vessel patency with primary percutaneous coronary intervention, coronary microvascular injury occurs in a large proportion of patients with ST-segment-elevation myocardial infarction, adversely affecting clinical and functional outcome. Ticagrelor has been reported to increase plasma adenosine levels, which might have a protective effect on the microcirculation. We investigated whether ticagrelor maintenance therapy after revascularized ST-segment-elevation myocardial infarction is associated with less coronary microvascular injury compared to prasugrel maintenance therapy. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035931DOI Listing
January 2019
1 Read

MRI findings in patients with acute coronary syndrome and unobstructed coronary arteries.

Diagn Interv Radiol 2019 Jan;25(1):28-34

Center for Clinical Medicine,University Faculty of Health, Witten/Herdecke, Germany.

Purpose: The underlying diagnosis in patients with acute coronary syndrome (ACS) and unobstructed coronary arteries remains a diagnostic challenge. We analyzed the value of magnetic resonance imaging (MRI) in this clinical setting.

Methods: A total of 213 patients with ACS and unobstructed coronary arteries underwent MRI within a median of 2 days after initial presentation. Read More

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http://dx.doi.org/10.5152/dir.2018.18004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339625PMC
January 2019
3 Reads

Coronary angioplasty in spontaneous coronary artery dissection-Strategy and outcomes.

Indian Heart J 2018 Nov - Dec;70(6):843-847. Epub 2018 Jan 9.

Department of Cardiology, Government Medical College, Thiruvananthapuram, Kerala, 695011, India.

Objective: To study the clinical, angiographic and technical characteristics of patients with spontaneous coronary artery dissection (SCAD) undergoing percutaneous coronary intervention (PCI).

Methods: This was a retrospective single center study where patients with angiographically confirmed SCAD undergoing PCI over a period of 4 years (2013-2017) were analyzed. We also sought to identify the clinical and angiographic predictors of procedural failure during PCI. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00194832173043
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http://dx.doi.org/10.1016/j.ihj.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306396PMC
January 2019
1 Read

Cardiac motion and spillover correction for quantitative PET imaging using dynamic MRI.

Med Phys 2019 Feb 15;46(2):726-737. Epub 2019 Jan 15.

Clinical Imaging Research Centre, A*STAR-NUS, 117599, Singapore.

Purpose: Cardiac positron emission tomography/magnetic resonance imaging (PET/MRI) acquisition presents novel clinical applications thanks to the combination of viability and metabolic imaging (PET) and functional and structural imaging (MRI). However, the resolution of PET, as well as cardiac and respiratory motion in nongated cardiac imaging acquisition protocols, leads to a reduction in image quality and severe quantitative bias. Respiratory or cardiac motion is customarily addressed with gated reconstruction which results in higher noise. Read More

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http://dx.doi.org/10.1002/mp.13345DOI Listing
February 2019

Impact of direct stenting on myocardial injury assessed by cardiac magnetic resonance imaging and prognosis in ST-elevation myocardial infarction.

Int J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Medical Clinic II, University Heart Center Lübeck, Lübeck, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany. Electronic address:

Background: The results of studies investigating the clinical benefit of a direct stenting (DS) strategy in ST-elevation myocardial infarction (STEMI) are inconsistent and data regarding cardiac magnetic resonance (CMR) parameters of myocardial injury are lacking. The aim of this study was to investigate the effect of DS on myocardial damage in comparison to a conventional stenting technique (CS) with predilation in patients with reperfused STEMI.

Methods: In a subanalysis of the randomized LIPSIA CONDITIONING trial (NCT02158468), STEMI patients were stratified according to the percutaneous coronary intervention technique into the DS (n = 171) or CS (n = 171) group after matching the patients for age (±5 years), gender, and TIMI flow before coronary intervention. Read More

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http://dx.doi.org/10.1016/j.ijcard.2018.11.141DOI Listing
December 2018

A case report of left atrial myxoma-induced acute myocardial infarction and successive stroke.

Medicine (Baltimore) 2018 Dec;97(51):e13451

Department of Neurology, First Affiliated Hospital of Chinese PLA General Hospital, Beijing, China.

Rationale: Left atrial myxoma is a common primary cardiac tumor, however, due to poor image quality or atypical myxoma images, it is often misdiagnosed by echocardiograph. A case of left atrial myxoma being misdiagnosed as a thrombus, which successively caused acute myocardial infarction (AMI) and stroke, is very rare. Contrast-enhanced echocardiography can play an important role in definitive diagnosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320038PMC
December 2018
4 Reads

Analysis of Cell Type-Specific Effects of MicroRNA-92a Provides Novel Insights Into Target Regulation and Mechanism of Action.

Circulation 2018 Nov;138(22):2545-2558

Institute of Cardiovascular Regeneration, Goethe University, Frankfurt, Germany (E.-M.R., W.T.A., C.B., D.J., M.H.S., J.K., A.F., A.B., S.D.).

Background: MicroRNAs (miRs) regulate nearly all biological pathways. Because the dysregulation of miRs can lead to disease progression, they are being explored as novel therapeutic targets. However, the cell type-specific effects of miRs in the heart are poorly understood. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.034598DOI Listing
November 2018

[Acute chest pain and normal high-sensitivity cardiac troponin levels; is this the end of the story?]

Authors:
Frans H Rutten

Ned Tijdschr Geneeskd 2018 Dec 5;162. Epub 2018 Dec 5.

Universiteit Utrecht, UMC Utrecht, divisie Julius Centrum voor Gezondheidswetenschappen en Eerstelijns Geneeskunde, afd. Huisartsgeneeskunde.

In patients presenting with acute chest pain, acute myocardial infarction should first be ruled out as a cause as these patients will often need coronary revascularisation. In the remaining patients, those with normal high-sensitivity cardiac troponin levels should undergo additional cardiac investigations to discriminate patients with an episode of unstable angina pectoris from those who have a non-cardiac cause of the chest pain. In the large majority (86%), the medical history does not raise suspicion of angina pectoris and an exercise test will show normal results; in these patients, further cardiac imaging does not seem to be indicated. Read More

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December 2018
2 Reads

Dynamic changes in injured myocardium, very early after acute myocardial infarction, quantified using T1 mapping cardiovascular magnetic resonance.

J Cardiovasc Magn Reson 2018 12 20;20(1):82. Epub 2018 Dec 20.

Acute Vascular Imaging Centre, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Background: It has recently been suggested that myocardial oedema follows a bimodal pattern early post ST-segment elevation myocardial infarction (STEMI). Yet, water content, quantified using tissue desiccation, did not return to normal values unlike oedema quantified by cardiovascular magnetic resonance (CMR) imaging. We studied the temporal changes in the extent and intensity of injured myocardium using T1-mapping technique within the first week after STEMI. Read More

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http://dx.doi.org/10.1186/s12968-018-0506-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300907PMC
December 2018
1 Read

Optical coherence tomography guided successful treatment without stent implantation in a patient with non-ST-segment elevation myocardial infarction caused by plaque rapture: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13669

Department of Cardiology Center, Hebei General Hospital, Shijiazhuang, Hebei Province, China.

Rationale: Primary percutaneous coronary intervention (PPCI) with immediate stenting provides effective revascularization. While the risks of no-reflow, stent thrombosis, stent undersizing, and malapposition reduced the benefits in patients with high burden thrombosis. Intravascular imaging, especially optical coherence tomography (OCT), offers potential in optimization of percutaneous coronary intervention. Read More

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http://dx.doi.org/10.1097/MD.0000000000013669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320136PMC
December 2018

Comparison of visual assessment and computer image analysis of intracoronary thrombus type by optical coherence tomography.

PLoS One 2018 17;13(12):e0209110. Epub 2018 Dec 17.

Heart Hospital, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

Background: Analysis of intracoronary thrombus type by optical coherence tomography (OCT) imaging is highly subjective. We aimed to compare a newly developed image analysis method to subjective visual classification of thrombus type identified by OCT.

Methods: Thirty patients with acute ST elevation myocardial infarction were included. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209110PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296537PMC
December 2018
2 Reads

Simultaneous detection of three biomarkers related to acute myocardial infarction based on immunosensing biochip.

Biosens Bioelectron 2019 Feb 6;126:767-772. Epub 2018 Dec 6.

Jiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China. Electronic address:

An immunosensing biochip for simultaneous detection of three biomarkers related to acute myocardial infarction (AMI) was developed based on anionic soybean peroxidase (SBP) functionalized nanoprobe and chemiluminescent imaging. The nanoprobes (Ab2-SiO-SBP) were fabricated by co-immobilization of SBP and one of the detection polyclonal antibodies, anti-cardiac troponin I antigen (anti-cTnI), anti-creatine kinase-MB (anti-CK-MB) and anti-myoglobin (anti-Myo), on the silica nanoparticle surface. The detection sensitivity was enhanced since the large surface area of silica carriers increased the loading of SBP for per sandwiched immunoreaction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663183094
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http://dx.doi.org/10.1016/j.bios.2018.11.044DOI Listing
February 2019
8 Reads

Changes in Coronary Plaque Composition in Patients With Acute Myocardial Infarction Treated With High-Intensity Statin Therapy (IBIS-4): A Serial Optical Coherence Tomography Study.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, Bern University Hospital, Bern, Switzerland.

Objectives: This study assessed changes in optical coherence tomography (OCT)-defined plaque composition in patients with ST-elevation myocardial infarction (STEMI) receiving high-intensity statin treatment.

Background: OCT is a high-resolution modality capable of measuring plaque characteristics including fibrous cap thickness (FCT) and macrophage infiltration. There is limited in vivo evidence regarding the effects of statins on OCT-defined coronary atheroma composition and no evidence in the context of STEMI. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.08.024DOI Listing
December 2018
2 Reads

Understanding the Tides of Myocardial Infarction.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Departments of Medicine and Diagnostic Radiology, McGill University Health Centre, Montreal, Quebec, Canada; Department of Medicine, Heidelberg University, Heidelberg, Germany; Department of Radiology, Université de Montréal, Montreal, Quebec, Canada; Department of Medicine and Radiology, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcmg.2018.03.031DOI Listing
December 2018
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Prognosis-based definition of left ventricular remodeling after ST-elevation myocardial infarction.

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria.

Objectives: Cardiac magnetic resonance (CMR) is the gold-standard modality for the assessment of left ventricular (LV) remodeling in ST-elevation myocardial infarction (STEMI) patients. However, the commonly used remodeling criteria have never been validated for hard clinical events. We therefore aimed to define clear CMR criteria of LV remodeling following STEMI with proven prognostic impact. Read More

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http://dx.doi.org/10.1007/s00330-018-5875-3DOI Listing
December 2018