299 results match your criteria Acute Multifocal Placoid Pigment Epitheliopathy


Cyclosporine and prednisolone combination therapy as a potential therapeutic strategy for relentless placoid chorioretinitis.

Am J Ophthalmol Case Rep 2019 Jun 23;14:87-91. Epub 2019 Mar 23.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Purpose: Relentless placoid chorioretinitis (RPC) is a new disease concept that was proposed by Jones et al. in 2000. Some cases of RPC have been reported; however, a treatment strategy has not yet been established. Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444293PMC

A case of acute posterior multifocal placoid pigment epitheliopathy with aseptic meningitis and cerebral infarction.

Rev Neurol (Paris) 2019 Mar 27. Epub 2019 Mar 27.

Service de neurologie, hôpitaux universitaires de Strasbourg, 67000 Strasbourg, France; Inserm U1434, centre d'investigation clinique, 67000 Strasbourg, France; Inserm U1119, biopathologie de la myéline, neuroprotection et stratégies thérapeutiques, fédération de médecine translationnelle de Strasbourg, 67000 Strasbourg, France.

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http://dx.doi.org/10.1016/j.neurol.2018.06.011DOI Listing

Intravitreal and posterior subtenon triamcinolone acetonide for severe acute posterior multifocal placoid pigment epitheliopathy.

Arq Bras Oftalmol 2019 Mar 25. Epub 2019 Mar 25.

Department of Ophthalmology, McGill University Health Centre, Montreal, Quebec, Canada.

A 21-year-old man presented with visual acuity of 20/200 in both eyes. The fundus picture, fluorescein angiography, and optical coherence tomography revealed severe bilateral acute posterior multifocal placoid pigment epitheliopathy and serous macular detachments. We treated the patient with triamcinolone acetonide, an intravitreal injection (4 mg/0. Read More

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http://dx.doi.org/10.5935/0004-2749.20190045DOI Listing
March 2019
1 Read

Acute posterior multifocal placoid pigment epitheliopathy after alemtuzumab treatment for relapsing-remitting multiple sclerosis.

J Neurol 2019 Mar 20. Epub 2019 Mar 20.

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1007/s00415-019-09288-yDOI Listing
March 2019
1 Read

Acute Posterior Multifocal Placoid Pigment Epitheliopathy Complicated by Fatal Cerebral Vasculitis.

J Neuroophthalmol 2019 Jan 22. Epub 2019 Jan 22.

Departments of Ophthalmology and Visual Sciences (RNM, GPVS, RR, GJH) and Neurology (LS), Washington University School of Medicine in St. Louis, St. Louis, Missouri; Blue Sky Neurology (NHK), Denver, Colorado; Department of Pathology and Immunology (CJF, RES, SD, GJH), Washington University School of Medicine, St. Louis, Missouri; Department of Radiology (JT), University of Colorado Anschutz Medical Campus, Aurora, Colorado; and Department of Neurology (AD), Brigham and Women's Hospital, Boston, Massachusetts.

A 21-year-old man experienced unilateral vision loss associated with multiple atrophic chorioretinal lesions. He was treated for a presumptive diagnosis of acute retinal necrosis, but his vision did not improve with antiviral therapy. Over the course of several weeks, his symptoms progressed to involve both eyes. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000750DOI Listing
January 2019
13 Reads

Similarities and differences between three different types of white dot syndrome and the therapeutic possibilities.

Rom J Ophthalmol 2018 Jul-Sep;62(3):183-187

Anatomy Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

White dot syndromes consists a group of inflammatory eye diseases with an unknown etiology involving the external retina, retinal pigment epithelium, choroid or combinations of them. They affect one or both eyes, at the same time or not. White dot syndromes are often self-limited, with a variable prognosis, depending on the type of the disease. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256077PMC
February 2019
2 Reads

Acute Posterior Multifocal Placoid Pigment Epitheliopathy Associated with Gastrointestinal Stromal Tumor and Hurthle Cell Tumor.

Case Rep Ophthalmol Med 2018 30;2018:1656131. Epub 2018 Sep 30.

Eye Institute, West Virginia University, Morgantown, WV, USA.

Acute posterior multifocal placoid pigment epitheliopathy (APMPEE) is a chorioretinal inflammatory disease of unknown origin. Patients usually present with a rapid loss of central/paracentral vision over the course of a week in both eyes. The fundus exhibits rapid appearance of multiple deep subretinal yellow-white, flat lesions at the RPE/choriocapillaris level. Read More

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http://downloads.hindawi.com/journals/criopm/2018/1656131.pd
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https://www.researchgate.net/profile/Nicholas_Jones6/publica
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http://www.cermlab.it/wp-content/uploads/cerm/RapportoCERM01
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https://www.hindawi.com/journals/criopm/2018/1656131/
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http://dx.doi.org/10.1155/2018/1656131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186340PMC
September 2018
16 Reads

Atypical white dot syndrome with choriocapillaris ischemia in a patient with latent tuberculosis.

J Ophthalmic Inflamm Infect 2018 Nov 3;8(1):20. Epub 2018 Nov 3.

Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia.

Background: White dot syndromes (WDS) are a group of idiopathic multifocal inflammatory conditions that can be recognized and distinguished by lesion morphology, other specific clinical features, imaging findings, and disease course. Our purpose is to describe an atypical case of WDS with choriocapillaris ischemia shown by multimodal imaging including swept-source OCT angiography (OCTA) in a 30-year-old woman with latent tuberculosis.

Findings: At presentation, visual acuity in the left eye was 20/500. Read More

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https://joii-journal.springeropen.com/articles/10.1186/s1234
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http://dx.doi.org/10.1186/s12348-018-0162-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215535PMC
November 2018
9 Reads

Optical coherence tomography angiography findings in a case with acute posterior multifocal placoid pigment epitheliopathy.

Eur J Ophthalmol 2018 Oct 10:1120672118804383. Epub 2018 Oct 10.

3 Department of Ophthalmology, School of Medicine, Dicle University, Diyarbakır, Turkey.

Twenty-six-year-old male patient admitted to the outpatient clinic with a complaint of decreased vision in both eyes. Visual acuity was 2/10 in the right and 7/10 in the left eye. Fundus examination revealed bilateral yellow-white subretinal lesions involving the macula. Read More

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http://journals.sagepub.com/doi/10.1177/1120672118804383
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http://dx.doi.org/10.1177/1120672118804383DOI Listing
October 2018
3 Reads

[Subretinal fluid in acute posterior multifocal placoid pigment epitheliopathy: A case report].

J Fr Ophtalmol 2018 Sep 31;41(7):e303-e305. Epub 2018 Aug 31.

Service d'ophtalmologie, CHU de Amiens Picardie, boulevard Laennec, 80054 Salouel, France.

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http://dx.doi.org/10.1016/j.jfo.2017.11.030DOI Listing
September 2018

Primary vitreoretinal lymphoma masquerading as acute posterior multifocal placoid pigment epitheliopathy.

Int J Ophthalmol 2018 18;11(7):1243-1244. Epub 2018 Jul 18.

Department of Surgical Sciences, Eye Clinic, University of Cagliari, Cagliari 09124, Italy.

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http://dx.doi.org/10.18240/ijo.2018.07.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048343PMC
July 2018
6 Reads

Neurologic Complications of Acute Posterior Multifocal Placoid Pigment Epitheliopathy: A Case Series of 4 Patients.

Neurohospitalist 2018 Jul 17;8(3):146-151. Epub 2018 Jan 17.

Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a self-limited idiopathic inflammatory ophthalmologic condition with characteristic funduscopic and fluorescein angiography findings. It is typically characterized by a flu-like prodrome followed by monocular or binocular vision loss. Often, prognosis is excellent with complete or near-complete recovery of vision. Read More

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http://journals.sagepub.com/doi/10.1177/1941874417749379
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http://dx.doi.org/10.1177/1941874417749379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022905PMC
July 2018
7 Reads

Choroidal perfusion abnormalities associated with Acute Posterior Multifocal Placoid Pigment Epitheliopathy: a case report.

BMC Ophthalmol 2018 Apr 10;18(1):87. Epub 2018 Apr 10.

Sacrocuore Hospital, Via Don Sempreboni 5 - Negrar, 37024, Verona, Italy.

Background: Indocyanine Green Angiography (ICG-A) and Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography (EDI-OCT) are essential imaging techniques for diagnosis, management and understanding of the pathophysiology of many chorioretinal diseases. Herein, we report the ICG-A and EDI-OCT findings from a case of Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE), in which these imaging techniques enable the visualization of more diagnostic details than those observable with other widely used diagnostic tools.

Case Presentation: A 60-year-old white female presented with bilateral blurred vision for few days. Read More

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http://dx.doi.org/10.1186/s12886-018-0756-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891904PMC
April 2018
27 Reads

Untreated Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE): a case series.

BMC Ophthalmol 2018 Mar 20;18(1):76. Epub 2018 Mar 20.

Department of Ophthalmology, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Université Paris Descartes, Paris, France.

Background: Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE) is a rare inflammatory eye disease that affects the Retinal Pigment Epithelium and outer retina. The purpose of this study was to describe its presentations, as well as its prognosis in a series of untreated patients.

Methods: Records of patients seen in the department of Ophthalmology at Cochin University Hospital, Paris, between April 2002 and June 2015 were retrospectively studied. Read More

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http://dx.doi.org/10.1186/s12886-018-0744-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859713PMC
March 2018
7 Reads

Ocular Complications in Influenza Virus Infection.

Ocul Immunol Inflamm 2018 Feb 8:1-6. Epub 2018 Feb 8.

a Department of Ophthalmology , Medical University of Warsaw , Warsaw , Poland.

Purpose: To describe a case series of ocular complications associated with upper respiratory tract infections.

Methods: Four patients aged 21-61 years (three females, one male) had confirmed ocular complications connected with a general upper respiratory tract infection with myalgia and fever. Ophthalmological examination, including a visual acuity test, a slit-lamp exam, intraocular pressure measurements, fluorescein and indocyanine green angiography, optical coherence tomography (OCT), and diagnostic tests for influenza were performed in the patients (RT-PCR, HAI). Read More

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http://dx.doi.org/10.1080/09273948.2017.1423335DOI Listing
February 2018
1 Read

Neuro-Ophthalmic Presentation of Neuro-Sweet Disease.

Neuroophthalmology 2017 Aug 15;41(4):202-206. Epub 2017 Mar 15.

Department of Neurological Sciences and Stanley Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Acute febrile neutrophilic dermatosis (Sweet syndrome) is a systemic inflammatory condition usually associated with autoimmune or neoplastic processes and characterised by inflammatory dermatologic lesions such as erythematous plaques and papules associated with fever and leukocytosis. Neurological and ophthalmological involvement is rare. The authors describe an unusual case of Sweet syndrome associated with microscopic polyangiitis presenting with papilloedema, anterior uveitis, and skin rash. Read More

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http://dx.doi.org/10.1080/01658107.2017.1291687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762142PMC
August 2017
5 Reads

A Rare Case of Infectious Multifocal Serpiginoid Choroiditis

Acta Clin Croat 2016 12;55(4):667-670

Department of Pathophysiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia

Multifocal serpiginoid choroiditis is an infectious variety of serpiginous choroiditis. The disease is characterized by infectious etiology and overlapping clinical features in an intermediary form of acute posterior multifocal placoid pigment epitheliopathy and serpiginous choroiditis. In a 33-year-old patient, bilateral multiple placoid partially confluent chorioretinal lesions were diagnosed after a febrile flu-like episode. Read More

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https://hrcak.srce.hr/index.php?show=clanak&id_clanak_je
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http://dx.doi.org/10.20471/acc.2016.55.04.21DOI Listing
December 2016
8 Reads

Application of OCT-angiography to characterise the evolution of chorioretinal lesions in acute posterior multifocal placoid pigment epitheliopathy.

Eye (Lond) 2017 Oct 6;31(10):1399-1408. Epub 2017 Oct 6.

Bristol Eye Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.

PurposeThe aim of this study was to determine a sequence of structural changes in acute posterior multifocal placoid pigment epitheliopathy (APMPPE) using optical coherence tomography-angiography (OCT-A) and comparing with other imaging modalities.Patients and methodsPatients with a new diagnosis of acute-onset APMPPE referred to a regional specialist centre from October 2015 to October 2016 were included. Multimodal imaging employed on all patients from diagnosis included the following: fundus fluorescein angiography, indocyanine green angiography, fundus autofluorescence, spectral domain-OCT (SD-OCT), and OCT-A. Read More

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http://dx.doi.org/10.1038/eye.2017.180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639187PMC
October 2017
2 Reads

Multimodal Evaluation of Patients with Acute Posterior Multifocal Placoid Pigment Epitheliopathy and Serpiginous Choroiditis.

Ocul Immunol Inflamm 2018 29;26(8):1212-1218. Epub 2017 Sep 29.

a Department of Ophthalmology and Visual Sciences , Paulista School of Medicine, Federal University of São Paulo , São Paulo , Brazil.

Purpose: To evaluate retinal and choroidal changes in patients with non-granulomatous choroiditis using the multimodality imaging (MMI).

Methods: Eight eyes of four patients were analyzed. Three patients (six eyes) were diagnosed with serpiginous choroiditis (SC) and one patient (two eyes) with acute posterior multifocal placoid pigment epitheliopathy (APMPPE). Read More

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http://dx.doi.org/10.1080/09273948.2017.1335757DOI Listing
December 2018
1 Read

Multi-Modal Imaging Including Optical Coherence Tomography Angiography in Patients With Posterior Multifocal Placoid Pigment Epitheliopathy.

Ophthalmic Surg Lasers Imaging Retina 2017 09;48(9):727-733

Background And Objective: New imaging methods provide novel insights into the pathogenesis of acute posterior multifocal placoid pigment epitheliopathy (APMPPE).

Patients And Methods: Four patients (eight eyes) in acute, subacute, and late phases of the disease were analyzed with multi-modal imaging methods including optical coherence tomography angiography (OCTA), structural OCT, fundus photography, and fundus autofluorescence. One patient was observed during the entire disease course. Read More

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http://dx.doi.org/10.3928/23258160-20170829-07DOI Listing
September 2017
6 Reads

Distinguishing White Dot Syndromes With Patterns of Choroidal Hypoperfusion on Optical Coherence Tomography Angiography.

Ophthalmic Surg Lasers Imaging Retina 2017 08;48(8):638-646

Background And Objective: To compare patterns of choroidal hypoperfusion in white dot syndromes (WDS) using optical coherence tomography angiography (OCTA).

Patients And Methods: Consecutive patients with WDS were imaged with either the Zeiss AngioPlex OCT Angiography (Carl Zeiss AG, Oberkochen, Germany) or the AngioVue OCT Angiography (Optovue, Fremont, CA) from February to November 2016. Four patients with acute posterior multifocal placoid pigment epitheliopathy (APMPPE), birdshot chorioretinopathy (BCR), presumed ocular histoplasmosis syndrome (POHS), and multiple evanescent white dot syndrome (MEWDS) were selected. Read More

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http://www.healio.com/doiresolver?doi=10.3928/23258160-20170
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http://dx.doi.org/10.3928/23258160-20170802-06DOI Listing
August 2017
63 Reads

[Infection-associated Acute Posterior Multifocal Placoid Pigment Epitheliopathy].

Klin Monbl Augenheilkd 2018 Sep 4;235(9):1049-1054. Epub 2017 Apr 4.

Klinik für Augenheilkunde, Universitätsklinikum Jena.

Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a rare inflammatory chorioretinopathy, which mainly affects young light-skinned, myopic adults between 20 and 30 years of age. The exact aetiology of APMPPE is unknown. Some patients report a viral or flu-like illness preceding the onset of APMPPE symptoms. Read More

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http://dx.doi.org/10.1055/s-0043-100629DOI Listing
September 2018
6 Reads

Multi-modal imaging and anatomic classification of the white dot syndromes.

Int J Retina Vitreous 2017 20;3:12. Epub 2017 Mar 20.

Department of Ophthalmology and Visual Sciences, University of Wisconsin, 600 Highland Ave, Madison, WI 53705 USA.

The white dot syndromes (WDS) are a diverse group of posterior uveitidies that share similar clinical findings but are unique from one another. Multimodal imaging has allowed us to better understand the morphology, the activity and age of lesions, and whether there is CNV associated with these different ocular pathologies. The "white dot syndromes" and their uveitic masqueraders can now be anatomically categorized based on lesion localization. Read More

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http://dx.doi.org/10.1186/s40942-017-0069-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357819PMC
March 2017
2 Reads

Observation and Clinical Pattern in Patients with White Dot Syndromes: The Role of Color Photography in Monitoring Ocular Changes in Long-Term Observation.

Med Sci Monit 2017 Mar 2;23:1106-1115. Epub 2017 Mar 2.

Department of Ophthalmology, Medical University of Warsaw, Warsaw, Poland.

BACKGROUND The aim of this study was to assess the clinical course and distinctive features of different white dot syndromes (WDS) in patients attending the Ophthalmology Department, Medical University of Warsaw in the years 1995-2015. MATERIAL AND METHODS Sixty-two (62) patients (43 females and 19 males), aged 18 to 77 years, referred with a WDS were included in this prospective study, with observation period ranging from 5 months to 16 years. All patients underwent a complete ophthalmological examination and multimodal imaging studies. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345700PMC
March 2017
30 Reads

CHARACTERIZING PHOTORECEPTOR CHANGES IN ACUTE POSTERIOR MULTIFOCAL PLACOID PIGMENT EPITHELIOPATHY USING ADAPTIVE OPTICS.

Retina 2018 Jan;38(1):39-48

Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Purpose: To characterize lesions of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) by multimodal imaging including adaptive optics scanning laser ophthalmoscopy (AOSLO).

Methods: We included patients with APMPPE at different stages of evolution of the placoid lesions. Color fundus photography, spectral domain optical coherence tomography, infrared reflectance, fundus autofluorescence, and AOSLO images were obtained and registered to correlate microstructural changes. Read More

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http://dx.doi.org/10.1097/IAE.0000000000001520DOI Listing
January 2018
23 Reads
2 Citations
3.243 Impact Factor

ACUTE POSTERIOR MULTIFOCAL PLACOID PIGMENT EPITHELIOPATHY ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Retina 2017 Nov;37(11):2084-2094

*Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; and †Department of Ophthalmology, Schepens Eye Research Institute/Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.

Purpose: To investigate choroidal involvement in acute posterior multifocal placoid pigment epitheliopathy (APMPPE).

Methods: A retrospective observational case series using multimodal imaging including optical coherence tomography (OCT) angiography.

Results: Five patients with APMPPE were included. Read More

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http://Insights.ovid.com/crossref?an=00006982-201711000-0001
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http://dx.doi.org/10.1097/IAE.0000000000001487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538964PMC
November 2017
5 Reads

Keeping the Name of Acute Posterior Multifocal Placoid Pigment Epitheliopathy.

JAMA Ophthalmol 2017 03;135(3):186

Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

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http://dx.doi.org/10.1001/jamaophthalmol.2016.5334DOI Listing
March 2017
4 Reads

Renaming of Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE) to Acute Multifocal Placoid Choroidopathy (AMP-C).

JAMA Ophthalmol 2017 03;135(3):185

Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1001/jamaophthalmol.2016.5325DOI Listing
March 2017
13 Reads

Acute Posterior Multifocal Placoid Pigment Epitheliopathy Associated With Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome.

JAMA Ophthalmol 2017 Feb;135(2):169-171

Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland2Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City.

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http://dx.doi.org/10.1001/jamaophthalmol.2016.5230DOI Listing
February 2017
6 Reads

Neurological Manifestations of Acute Posterior Multifocal Placoid Pigment Epitheliopathy.

J Clin Neurol 2016 Oct;12(4):460-467

King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.

Background And Purpose: Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is an immune-mediated chorioretinal disease that causes acute visual symptoms with characteristic ophthalmoscopic findings. Neurological complications are rarely reported in the literature. Here we report two new cases of APMPPE that presented with neurological manifestations, one of which was associated with peripheral neuropathy, which has not been described before. Read More

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http://dx.doi.org/10.3988/jcn.2016.12.4.460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063873PMC
October 2016
9 Reads

OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY SHOWS INNER CHOROIDAL ISCHEMIA IN ACUTE POSTERIOR MULTIFOCAL PLACOID PIGMENT EPITHELIOPATHY.

Retin Cases Brief Rep 2017 Winter;11 Suppl 1:S136-S143

*Vitreous Retina Macula Consultants of New York, New York, New York; †LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York; ‡Retinal Disorders and Ophthalmic Genetics Division, Jules Stein Eye Institute, University of California, Los Angeles, California; §Greater Los Angeles VA Healthcare Center, Los Angeles, California; ¶Department of Ophthalmology, Staten Island University Hospital, New York, New York; **Department of Ophthalmology, Edward S Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, New York; and ††Department of Ophthalmology, New York University School of Medicine, New York, New York.

Purpose: To describe multimodal imaging findings of an evolving case of acute posterior multifocal placoid pigment epitheliopathy occurring in a young healthy male.

Methods: Case report of a patient with acute posterior multifocal placoid pigment epitheliopathy including comprehensive systemic and ocular examinations. Ultra-widefield autofluorescence, fluorescein angiography, indocyanine green angiography, and serial optical coherence tomography angiography were performed. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000473DOI Listing

WHY THE DOTS ARE BLACK ONLY IN THE LATE PHASE OF THE INDOCYANINE GREEN ANGIOGRAPHY IN MULTIPLE EVANESCENT WHITE DOT SYNDROME.

Retin Cases Brief Rep 2017 Winter;11 Suppl 1:S81-S85

*Service d'Ophtalmologie, AP-HP, Hôpital Lariboisière, Université Paris Diderot, Paris, France; and †Quinze-Vingts Hospital Departement Hospitalo-Universitaire SightMaintain, Institut National de la Recherche Medicale (INSERM)-Direction de l'Hospitalisation et de l'Organisation des Soins CIC, Paris, France.

Purpose: To determine what retinal layer is primarily involved in multiple evanescent white dot syndrome compared with acute posterior multifocal placoid pigment epitheliopathy using multimodal imaging including indocyanine green angiography.

Methods: Color fundus photographs and fluorescein angiography, ICGA and spectral domain optical coherence tomography images of two typical acute cases, one of acute posterior multifocal placoid pigment epitheliopathy and one of multiple evanescent white dot syndrome, were assessed and compared.

Results: In both diseases, white plaques or dots were seen at the posterior pole. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000422DOI Listing
April 2017
15 Reads

A case of unilateral and spontaneously resolving posterior uveitis with overlapping features of Vogt-Koyanagi-Harada disease and Acute Posterior Multifocal Placoid Pigment Epitheliopathy.

Springerplus 2016 1;5(1):1471. Epub 2016 Sep 1.

Ivey Eye Institute, Western University, London, ON Canada.

Introduction: VKH disease is a chronic, bilateral, granulomatous panuveitis with potential involvement of neurological, auditory and integumentary systems. On the other hand, APMPPE is believed to be an immune-driven chorioretinal vascular disease characterized by multifocal, flat, grey-white placoid lesions at the level of the RPE. We describe a case with overlapping figures of both conditions. Read More

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http://dx.doi.org/10.1186/s40064-016-3132-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009056PMC
September 2016
23 Reads

Relentless placoid chorioretinitis – A case report.

Srp Arh Celok Lek 2016 Sep-Oct;144(9-10):527-30

Introduction: Relentless placoid chorioretinitis is an entity which belongs to the group of an atypical intermediate form of primary inflammatory choriocapillaropathies, resembling both acute posterior multifocal placoid pigment epitheliopathy and serpiginous choroiditis, but the retinal distribution and clinical course are not the same. Because of this similarity this entity was termed “AMPPiginous”. This entity was first described by Jones et al. Read More

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April 2018
9 Reads

Acute posterior multifocal placoid pigment epitheliopathy and granulomatous uveitis following influenza vaccination.

Am J Ophthalmol Case Rep 2016 Dec 31;4:60-63. Epub 2016 Aug 31.

Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan.

Purpose: To report a case of acute placoid multifocal posterior pigment epitheliopathy (APMPPE) following influenza vaccination. The patient exhibited granulomatous uveitis during the recovery phase.

Observations: A woman in her thirties developed flu-like symptoms seven days after receiving an influenza vaccination. Read More

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http://dx.doi.org/10.1016/j.ajoc.2016.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757482PMC
December 2016
4 Reads

LONGITUDINAL QUANTITATIVE EVALUATION OF OUTER RETINAL LESIONS IN ACUTE POSTERIOR MULTIFOCAL PLACOID PIGMENT EPITHELIOPATHY USING OPTICAL COHERENCE TOMOGRAPHY.

Retina 2017 May;37(5):851-857

*Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; and †G.B. Bietti Eye Foundation-IRCCS, Rome, Italy.

Purpose: To quantify the external limiting membrane (ELM) disruption and photoreceptor volume changes in eyes with acute posterior multifocal placoid pigment epitheliopathy (APMPPE) using Spectral Domain Optical Coherence Tomography (SD-OCT) at the acute and resolution phases.

Methods: Retrospective study of 10 eyes of 5 patients with APMPPE. Intact ELM and the Bruch's membrane were manually traced using ImageJ software and their lengths from each scan of the Spectral Domain Optical Coherence Tomography macular volume were summed. Read More

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http://dx.doi.org/10.1097/IAE.0000000000001245DOI Listing
May 2017
1 Read

Vascular rarefaction at the choriocapillaris in acute posterior multifocal placoid pigment epitheliopathy viewed on OCT angiography.

Int Ophthalmol 2017 Jun 28;37(3):733-736. Epub 2016 Jul 28.

Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.

Few cases have been reported describing choroidal vasculature in acute posterior multifocal placoid pigment epitheliopathy (APMPPE) using optical coherence tomography (OCT) angiography. We report choroidal vasculature changes in an APMPPE patient with the clinical course characterized by OCT angiography. A 39-year-old female was referred to us for bilateral multiple white spots in bilateral fundus. Read More

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http://dx.doi.org/10.1007/s10792-016-0308-2DOI Listing
June 2017
38 Reads

Multimodal Imaging in Acute Posterior Multifocal Placoid Pigment Epitheliopathy Demonstrating Obstruction of the Choriocapillaris.

Ophthalmic Surg Lasers Imaging Retina 2016 07;47(7):677-81

Optical coherence tomography angiography (OCTA) provides noninvasive in vivo vascular imaging of the retina and choriocapillaris. To highlight OCTA utility, the authors align structural changes and their resolution with functional outcome. The authors present a case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and sequential changes during transition to inactive disease. Read More

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http://dx.doi.org/10.3928/23258160-20160707-12DOI Listing
July 2016
20 Reads

Acute Borrelia infection inducing an APMPPE-like picture.

J Ophthalmic Inflamm Infect 2016 Dec 13;6(1):22. Epub 2016 Jun 13.

Vitreoretinal Unit, University Eye Hospital, Frankfurt/Main, 60590, Hessen, Germany.

Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is an uncommon disorder of unknown etiology affecting the retina, the retinal pigment epithelium, and the choroid. Although several etiological factors have been suggested, none has been confirmed. We report a case of APMPPE associated with acute infection of Borreliosis. Read More

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http://dx.doi.org/10.1186/s12348-016-0088-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905935PMC
December 2016
11 Reads

Acute posterior multifocal placoid pigment epitheliopathy in a patient with familial Mediterranean fever.

Clin Exp Optom 2016 Jul 9;99(4):385-7. Epub 2016 Jun 9.

Division of Rheumatology, Department of Internal Medicine, University of Patras, Medical School, Greece.

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http://dx.doi.org/10.1111/cxo.12401DOI Listing
July 2016
1 Read

Neurological complications of acute multifocal placoid pigment epitheliopathy.

J Clin Neurosci 2016 Sep 12;31:76-80. Epub 2016 May 12.

Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address:

Acute multifocal placoid pigment epitheliopathy (AMPPE) is an autoimmune chorioretinal disease that can be complicated by neurological involvement. There is limited information on this potentially treatable condition in the neurological literature. The objective of this patient series is to describe the neurological complications of AMPPE. Read More

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http://dx.doi.org/10.1016/j.jocn.2016.02.012DOI Listing
September 2016
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[OCT angiography findings in acute posterior multifocal placoid pigment epitheliopathy (APMPPE)].

Ophthalmologe 2017 Jan;114(1):60-65

Klinik und Poliklinik für Augenheilkunde, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Deutschland.

This article reports the case of a 32-year-old female patient who presented with severe spasmodically occurring retrobulbar pain, headaches and light sensitivity. The neurological examination confirmed cephalalgia but no evidence of other neurological symptoms was found. Ophthalmoscopy revealed yellowish patchy lightened spots in the middle periphery. Read More

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http://dx.doi.org/10.1007/s00347-016-0256-2DOI Listing
January 2017

ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY FEATURES IN AREAS OF CHORIOCAPILLARIS HYPOPERFUSION.

Retina 2016 Oct;36(10):2013-21

*Eye Clinic, Department of Biomedical and Clinical Science, Luigi Sacco Hospital, University of Milan, Milan, Italy; †Ophthalmological Unit, Department of Clinical Sciences and Community Health, IRCCS-Cà Granda Foundation-Ospedale Maggiore Policlinico, University of Milan, Milan, Italy; and ‡Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska.

Purpose: To detect choriocapillaris changes by enhanced depth imaging optical coherence tomography (EDI-OCT) in areas of choriocapillaris hypoperfusion visualized on indocyanine green angiography.

Methods: Combined indocyanine green angiography and EDI-OCT from patients diagnosed with inflammatory choriocapillaris hypoperfusion were retrospectively analyzed. The EDI-OCTs were compared with indocyanine green angiography to detect choriocapillaris changes suggestive of choriocapillaris hypoperfusion in both active stage (AS) and inactive stage of the disease. Read More

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http://dx.doi.org/10.1097/IAE.0000000000001031DOI Listing
October 2016
17 Reads

Increased choroidal blood flow velocity with regression of acute posterior multifocal placoid pigment epitheliopathy.

Jpn J Ophthalmol 2016 May 28;60(3):172-8. Epub 2016 Mar 28.

Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Purpose: To quantitatively examine changes in choroidal circulation hemodynamics in patients with acute posterior multifocal placoid pigment epitheliopathy (APMPPE).

Methods: Retrospective observational case series. Five eyes of 3 APMPPE patients were included. Read More

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http://dx.doi.org/10.1007/s10384-016-0440-6DOI Listing
May 2016
11 Reads

TUBULOINTERSTITIAL NEPHRITIS AND UVEITIS SYNDROME WITH A PRIMARY PRESENTATION OF ACUTE POSTERIOR MULTIFOCAL PLACOID PIGMENT EPITHELIOPATHY.

Retin Cases Brief Rep 2017 Spring;11(2):100-103

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.

Purpose: To report a case of tubulointerstitial nephritis and uveitis syndrome with a primary presentation of acute posterior multifocal placoid pigment epitheliopathy after use of lamotrigine.

Methods: Retrospective case report with ultra-widefield fundus imaging, optical coherence tomography, and fluorescein angiography.

Results: A 19-year-old woman presented with decreased visual acuity and acute renal failure after starting lamotrigine. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000299DOI Listing
September 2017
1 Read

A Case of Ampiginous Choroiditis.

Case Rep Ophthalmol 2015 Sep-Dec;6(3):453-7. Epub 2015 Dec 12.

Department of Ophthalmology, Ghent University Hospital, Ghent, Belgium.

Purpose: Presentation of a case report of a unilateral ampiginous choroiditis.

Methods: This is an observational case report.

Results: A 70-year-old woman was referred to us with unilateral scattered chorioretinal lesions. Read More

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http://dx.doi.org/10.1159/000442742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777937PMC
March 2016
4 Reads

Acute Posterior Multifocal Placoid Pigment Epitheliopathy Following Dengue Fever: A New Association for an Old Disease.

Ocul Immunol Inflamm 2016 Dec 22;24(6):610-614. Epub 2016 Feb 22.

a Department of Ophthalmology , Bascom Palmer Eye Institute, University of Miami Miller School of Medicine , Miami , Florida , USA.

Purpose: An association between antecedent viral illness and acute posterior multifocal placoid pigment epitheliopathy (APMPPE) has long been suspected. The authors propose dengue fever as a possible cause of APMPPE, based on three patients who travelled to or lived in endemic areas and had serologic evidence of prior exposure.

Methods: Review of case records of two patients. Read More

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http://dx.doi.org/10.3109/09273948.2015.1125513DOI Listing
December 2016
7 Reads

Acute posterior multifocal placoid pigment epitheliopathy presenting with multiple brain and spinal cord infarctions.

J Neurol Sci 2016 Feb 9;361:26-8. Epub 2015 Dec 9.

Department of Neurology, Centro Hospitalar de São João, Portugal; Faculty of Medicine of University of Porto, Portugal.

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http://dx.doi.org/10.1016/j.jns.2015.12.015DOI Listing
February 2016
9 Reads

Choroidal Involvement in Acute Posterior Multifocal Placoid Pigment Epitheliopathy.

Ophthalmic Surg Lasers Imaging Retina 2016 Jan;47(1):20-6

Background And Objective: To evaluate choroidal involvement in acute posterior multifocal placoid pigment epitheliopathy (APMPPE).

Patients And Methods: Retrospective study in five eyes of three patients evaluated through multimodal imaging, including enhanced-depth imaging optical coherence tomography (OCT), ultra-wide field color photography, fundus autofluorescence, and fluorescein angiography (FA). Choroidal thickness and structure were evaluated on OCT. Read More

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http://dx.doi.org/10.3928/23258160-20151214-03DOI Listing
January 2016