Expert Rev Anticancer Ther 2022 Jun 22. Epub 2022 Jun 22.
A/31, 65-D, Bafna Courts, West Ponnurangam Road, RS Puram, Coimbatore, India.
Introduction: AYA-ALL differs from pediatric ALL in terms of clinical, biological, psychosocial factors and access to care and has an inferior outcome. It is now being recognized that pediatric-inspired protocols are superior to adult protocols for this cohort, but given the lack of randomized trials, several questions remain unanswered.
Areas Covered: In this review, we discuss how AYA-ALL is different from the pediatric ALL population, compare AYA ALL with ALL in middle and older age adults, review the studies that have enrolled the AYA cohort, summarize risk-stratified and response-adapted approaches, describe the biological subtypes, and review the novel agents/approaches under evaluation. Read More