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    Serum HBV DNA plus RNA shows superiority in reflecting the activity of intrahepatic cccDNA in treatment-naïve HBV-infected individuals.
    J Clin Virol 2018 Jan 6;99-100:71-78. Epub 2018 Jan 6.
    Department of Microbiology & Infectious Disease Center, Peking University Health Science Center, Beijing, China. Electronic address:
    Background: Both serum hepatitis B virus (HBV) DNA and RNA can reflect intrahepatic covalently closed circular DNA (cccDNA) activity. However, correlations among viral markers haven't been fully explored.

    Objectives: Here we investigated the correlations between serum HBV RNA and other viral markers in acute hepatitis B patients and treatment-naïve chronic HBV-infected individuals. Read More

    Recombinant Relaxin Protects Liver Transplants from Ischemia Damage via Hepatocyte Glucocorticoid Receptor: From Bench-to-Bedside.
    Hepatology 2018 Jan 19. Epub 2018 Jan 19.
    Department of Surgery, Division of Liver and Pancreas Transplantation, The Dumont-UCLA Transplant Center.
    Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and acute/chronic rejection as well as a key obstacle to expanding the donor pool in orthotopic liver transplantation (OLT). Although glucocorticoid receptor (GR) signaling may enhance cytoprotective programs, clinical use of glucocorticoid is limited due to adverse effects, while clinical relevance of GR-facilitated cytoprotection in OLT remains unknown. We aimed to evaluate the significance of hepatic GR in clinical OLT and verify the impact of recombinant human relaxin (rhRLX), which may function as GR agonist in tissue/disease-specific manner. Read More

    Biochemical changes and clinical outcomes in 34 patients with classic galactosemia.
    J Inherit Metab Dis 2018 Jan 19. Epub 2018 Jan 19.
    Department of Pathology, University of Utah, Salt Lake City, UT, USA.
    Impaired activity of galactose-1-phosphate uridyltransferase (GALT) causes galactosemia, an autosomal recessive disorder of galactose metabolism. Early initiation of a galactose-restricted diet can prevent or resolve neonatal complications. Despite therapy, patients often experience long-term complications including speech impairment, learning disabilities, and premature ovarian insufficiency in females. Read More

    Membranoproliferative glomerulonephritis and interstitial nephritis in the setting of Epstein-Barr virus-related hemophagocytic syndrome
.
    Clin Nephrol 2018 Jan 19. Epub 2018 Jan 19.
    Background: Hemophagocytic syndrome (HPS) is a rare, aggressive disorder characterized by dysregulation of lymphocyte and macrophage activity, which culminates in tissue infiltration with hemophagocytosis and ultimately organ failure. Renal involvement frequently ensues and usually results in acute tubular necrosis with associated interstitial inflammation. Less frequently, glomerulopathy can also be found. Read More

    AMP-activated protein kinase agonist N6-(3-hydroxyphenyl)adenosine protects against fulminant hepatitis by suppressing inflammation and apoptosis.
    Cell Death Dis 2018 Jan 18;9(2):37. Epub 2018 Jan 18.
    Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), 100193, Beijing, China.
    Both AMP-activated protein kinase (AMPK) agonist and inhibitor have been reported to protect against fulminant hepatitis, implying that AMPK may play a complicated role in the development of fulminant hepatitis. In this study, we exploited whether the novel AMPK agonist N6-(3-hydroxyphenyl)adenosine (named as M1) exerted protective effects on fulminant hepatitis and whether its beneficial effects were AMPK-dependent. Results showed that intraperitoneal injection of M1 improved liver function, ameliorated liver injury and finally raised the survival rate in D-galactosamine/lipopolysaccharide (GalN/LPS)-treated mice. Read More

    Proliferation and survival of human amniotic epithelial cells during their hepatic differentiation.
    PLoS One 2018 18;13(1):e0191489. Epub 2018 Jan 18.
    Universidad de Buenos Aires, CONICET, Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Ciudad Universitaria Pabellón 2, 4° piso, (1428), Buenos Aires, Argentina.
    Stem cells derived from placental tissues are an attractive source of cells for regenerative medicine. Amniotic epithelial cells isolated from human amnion (hAECs) have desirable and competitive characteristics that make them stand out between other stem cells. They have the ability to differentiate toward all three germ layers, they are not tumorigenic and they have immunosuppressive properties. Read More

    Hepatitis B screening before rituximab therapy: a multicentre South Australian study of adherence.
    Intern Med J 2018 Jan 18. Epub 2018 Jan 18.
    Consultant Gastroenterologist, Hepatology and Liver Transplant Medicine Unit, Flinders Medical Centre.
    Background and Aims International guidelines recommend screening for Hepatitis B virus (HBV) infection prior to administration of rituximab, due to high risk of HBV reactivation in at risk patients. The aim of this study was to determine; (1) adherence to the South Australian (SA) protocol for HBV screening, (2) HBV prevalence in patients receiving rituximab, and (3) outcomes of patients at risk of HBV reactivation.

    Methods: All patients commenced on rituximab at the 6 major SA public hospitals during a 12-month period were included in the study. Read More

    Improving survival of acute-on-chronic liver failure patients complicated with invasive pulmonary aspergillosis.
    Sci Rep 2018 Jan 17;8(1):876. Epub 2018 Jan 17.
    Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
    The mortality of acute-on-chronic liver failure (ACLF) patients complicated with invasive pulmonary aspergillosis (IPA) was extremely high. We aimed to explore prognostic value of the Chronic Liver Failure-Sequential Organ Failure Assessment (CLIF-SOFA) lung score and to establish an optimal voriconazole regimen for ACLF patients complicated with IPA. We retrospectively screened hospitalized ACLF patients in our hospital from July 2011 to April 2016, from which 20 probable IPA cases were diagnosed. Read More

    Wilson’s Disease in Children: A Position Paper by the Hepatology Committee of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition.
    J Pediatr Gastroenterol Nutr 2017 10 26. Epub 2017 Oct 26.
    Pediatric Hepatology Unit, Centre national de référence de la maladie de Wilson, Hôpital Necker-APHP, Paris, France.
    Background: Clinical presentations of Wilson's disease (WD) in childhood ranges from asymptomatic liver disease to cirrhosis or acute liver failure, while neurological and psychiatric symptoms are rare. The basic diagnostic approach includes serum ceruloplasmin and 24h-urinary copper excretion. Final diagnosis of WD can be established using a diagnostic scoring system based on symptoms, biochemical tests assessing copper metabolism and molecular analysis of mutations in the ATP7B gene. Read More

    Osmotic Shifts, Cerebral Edema, and Neurologic Deterioration in Severe Hepatic Encephalopathy.
    Crit Care Med 2018 Feb;46(2):280-289
    Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
    Objectives: We sought to determine the effect of acute electrolyte and osmolar shifts on brain volume and neurologic function in patients with liver failure and severe hepatic encephalopathy.

    Design: Retrospective analysis of brain CT scans and clinical data.

    Setting: Tertiary care hospital ICUs. Read More

    [N-acetylcysteine : effective treatment in severe alcoholic hepatitis ?]
    Rev Med Suisse 2018 Jan;14(590):146-149
    Service de médecine interne générale, HUG, 1211 Genève 14.
    The use of N-acetylcysteine is of unknown significance when it comes to acute liver failure of other origin but for paracetamol overdose. Current data state its beneficial use when added to standard treatment for acute alcoholic hepatitis, whereas this attitude is less clear for hepatitis of variable other origin. This review of literature attends to evaluate and reveal the possible interest of adding N-acetylcysteine to standard care of acute liver failure due to alcoholism or other non-paracetamol linked causes. Read More

    A Multicenter Pilot Survey to Clarify the Clinical Features of Patients with Acute-On-Chronic Liver Failure in Japan.
    Hepatol Res 2018 Jan 17. Epub 2018 Jan 17.
    Department of Gastroenterology & Hepatology, Saitama Medical University.
    Aims: To establish diagnostic criteria for acute-on-chronic liver failure (ACLF) in Japan, a multicenter pilot survey was conducted to examine usefulness of oversea criteria in patients with chronic liver diseases manifesting acute decompensation.

    Methods: Patients fulfilling the APASL, EASL or Chinese Medical Association (CMA) criteria for decompensation were enrolled from 8 institutes, and the clinical features were evaluated.

    Results: Among 112 patients, 109 patients (97. Read More

    Early failure of kidney transplants in the current era - a national cohort study.
    Transpl Int 2018 Jan 16. Epub 2018 Jan 16.
    Transplantation and Liver surgery, Helsinki University Hospital, Helsinki, Finland.
    Although short-term outcome after kidney transplantation has improved, a small proportion of grafts are lost during the first year. We characterize in detail all early graft losses in the current era in a nationwide cohort of kidney transplant recipients. Altogether 2447 kidney transplantations, performed between June 2004 and October 2016, were included. Read More

    ACG Clinical Guideline: Alcoholic Liver Disease.
    Am J Gastroenterol 2018 Jan 16. Epub 2018 Jan 16.
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
    Alcoholic liver disease (ALD) comprises a clinical-histologic spectrum including fatty liver, alcoholic hepatitis (AH), and cirrhosis with its complications. Most patients are diagnosed at advanced stages and data on the prevalence and profile of patients with early disease are limited. Diagnosis of ALD requires documentation of chronic heavy alcohol use and exclusion of other causes of liver disease. Read More

    Development and validation of a scoring system to predict progression to acute-on-chronic liver failure in patients with acute exacerbation of chronic hepatitis B.
    Hepatol Res 2018 Jan 15. Epub 2018 Jan 15.
    Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical College, 201 Dalian street, Zunyi, Guizhou, 563003, China.
    Aim: The aim of this study was to develop and validate a scoring system to predict the progression to acute-on-chronic liver failure (ACLF) in patients with acute exacerbation (AE) of chronic hepatitis B (CHB).

    Methods: The baseline characteristics of 474 patients with AE of CHB were retrospectively reviewed; 280 and 194 patients were randomly assigned to the derivation and validation cohorts, respectively. Univariate risk factors associated with ACLF development were entered into a multivariate logistic regression. Read More

    Acute-on-chronic liver failure in chronic hepatitis B: an update.
    Expert Rev Gastroenterol Hepatol 2018 Jan 16:1-10. Epub 2018 Jan 16.
    a Department of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine , Zhejiang University , Hangzhou , China.
    Introduction: Acute-on-chronic liver failure is a common pattern of end-stage liver disease in clinical practice and occurs frequently in patients with chronic hepatitis B or HBV-related cirrhosis. New progress in recent years leads to a better understanding of this disease. Areas covered: This review updates the current comprehensive knowledge about HBV-ACLF from epidemiological studies, experimental studies, and clinical studies and provide new insights into the definition, diagnostic criteria, epidemiology, nature history, pathogenesis, treatment and prognostication of HBV-ACLF. Read More

    Factors associated with waiting time on the liver transplant list: an analysis of the United Network for Organ Sharing (UNOS) database.
    Ann Gastroenterol 2018 Jan-Feb;31(1):84-89. Epub 2017 Nov 27.
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
    Background: Liver transplantation (LT) is an important treatment for acute liver failure and end-stage liver disease. In 2002, the model for end-stage liver disease (MELD) score was incorporated to prioritize patients awaiting LT. Although there is data on how the MELD score affects waiting times, there is a paucity of literature regarding other components. Read More

    Activation of p62-keap1-Nrf2 antioxidant pathway in the early stage of acetaminophen-induced acute liver injury in mice.
    Chem Biol Interact 2018 Jan 10. Epub 2018 Jan 10.
    Institute of Toxicology, Shandong University, 44 West Wenhua Road, Jinan, Shandong, 250012, PR China. Electronic address:
    Acetaminophen (APAP) overdose can cause severe liver failure even death. Nearly half of drug-induced liver injury is attributed to APAP in the US and many European countries. Oxidative stress has been validated as a critical event involved in APAP-induced liver failure. Read More

    Atypical Presentation of Pregnancy-Related Hemolytic Uremic Syndrome.
    Am J Kidney Dis 2018 Jan 10. Epub 2018 Jan 10.
    Division of Nephrology, Penn State Milton S. Hershey Medical Center, Hershey, PA. Electronic address:
    The cause of acute kidney injury during pregnancy and in the postpartum period can be particularly challenging to diagnose, especially when it is necessary to differentiate among preeclampsia; eclampsia; hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome; and thrombotic microangiopathies (TMAs). All these disease entities can present with kidney failure, microangiopathic hemolytic anemia, and thrombocytopenia. We present a teaching case of atypical hemolytic uremic syndrome in the postpartum period in a young woman who was found to have mutations of uncertain clinical significance in the complement cascade, including in C3, CFH, and CFI. Read More

    Clinical Profile and Outcome of Pregnant Patients with Acute HEV Hepatitis During Water Borne Epidemic in Himachal Pradesh: A Hospital Based Study.
    J Assoc Physicians India 2017 Dec;65(12):44-48
    Student, MPH, Punjab University, Chandigarh; *Corresponding Author.
    Background: Recent outbreak of HEV hepatitis epidemic in Himachal Pradesh in Shimla caused significant morbidity and mortality especially among pregnant patients. Overall mortality is 0.5- 4% in patients developing acute hepatic failure (ALF) and is significantly higher in pregnant patients (20%). Read More

    Amatoxin-Containing Mushroom Poisonings: Species, Toxidromes, Treatments, and Outcomes.
    Wilderness Environ Med 2018 Jan 8. Epub 2018 Jan 8.
    Department of Environmental and Occupational Health Sciences, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA. Electronic address:
    Amatoxins are produced primarily by 3 species of mushrooms: Amanita, Lepiota, and Galerina. Because amatoxin poisonings are increasing, the objective of this review was to identify all amatoxin-containing mushroom species, present a toxidromic approach to earlier diagnoses, and compare the efficacies and outcomes of therapies. To meet these objectives, Internet search engines were queried with keywords to select peer-reviewed scientific articles on amatoxin-containing mushroom poisoning and management. Read More

    [Clinical value of anti-liver/kidney microsomal-1 antibody in patients with liver disease].
    Zhonghua Gan Zang Bing Za Zhi 2017 Nov;25(11):852-857
    Department of Hepatitis Immunity, Beijing You'an Hospital Affiliated to Capital Medical University, Beijing 100069, China.
    Objective: To investigate the clinical and laboratory features of patients with liver disease and positive anti-liver/kidney microsomal-1 (anti-LKM-1) antibody, and to provide a reference for clinical diagnosis and differential diagnosis. Methods: The clinical data of patients with positive anti-LKM-1 antibody who were treated in our hospital from 2006 to 2016 were collected, and clinical and laboratory features were analyzed and compared. An analysis was also performed for special cases. Read More

    Profile, risk factors and outcome of acute kidney injury in pediatric acute-on-chronic liver failure.
    Liver Int 2018 Jan 11. Epub 2018 Jan 11.
    Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
    Background & Aims: There are no studies on acute kidney injury (AKI) in pediatric acute-on-chronic liver failure (ACLF). This study was planned with aim to describe the clinical presentation and outcome of AKI among pediatric ACLF patients METHODS: Data of all children 1-18 years of age presenting with ACLF (APASL definition) was reviewed. AKI was defined as per KDIGO guidelines. Read More

    Modulation of O-GlcNAc levels in the liver impacts acetaminophen-induced liver injury by affecting protein adduct formation and glutathione synthesis.
    Toxicol Sci 2018 Jan 9. Epub 2018 Jan 9.
    The Department of Pharmacology, Toxicology and Therapeutics.
    Overdose of acetaminophen (APAP) results in acute liver failure. We have investigated the role of a post-translational modification of proteins called O-GlcNAcylation, where the O-GlcNAc transferase (OGT) adds and O-GlcNAcase (OGA) removes a single β-D-N-acetylglucosamine (O-GlcNAc) moiety, in the pathogenesis of APAP-induced liver injury. Hepatocyte specific OGT knockout mice (OGT KO), which have reduced O-GlcNAcylation, and WT controls were treated with 300 mg/kg APAP and the development of injury was studied over a time course from 0-24 hr. Read More

    Inhibition of UDP-glucose dehydrogenase by 6-thiopurine and its oxidative metabolites: Possible mechanism for its interaction within the bilirubin excretion pathway and 6TP associated liver toxicity.
    J Pharm Biomed Anal 2017 Dec 30;151:106-115. Epub 2017 Dec 30.
    Department of Chemistry, Kansas State University, 1212 Mid-Campus Drive North, 203 CBC Building, Manhattan, KS 66506, United States. Electronic address:
    6-Thiopurine (6TP) is an actively prescribed drug in the treatment of various diseases ranging from Crohn's disease and other inflammatory diseases to acute lymphocytic leukemia and non-Hodgkin's leukemia. While 6TP has beneficial therapeutic uses, severe toxicities are also reported with its use, such as jaundice and liver toxicity. While numerous investigations into the mode in which toxicity originates has been undertaken. Read More

    Clinical and virological implications of A1846T and C1913A/G mutations of hepatitis B virus genome in severe liver diseases.
    Scand J Gastroenterol 2018 Jan 11:1-10. Epub 2018 Jan 11.
    a Institute of Infectious Diseases and Liver Failure Medical Center , Beijing 302 Hospital , Beijing , P.R. China.
    Objective: Mutations occurring within different genes of hepatitis B virus (HBV) genome may have different clinical implications. This study aimed to observe the clinical and virological implications of the A1846T and C1913A/G mutations of HBV genome in the development and treatment outcome of severe liver diseases, which has not been previously determined.

    Materials And Methods: A total of 438 cases of patients with liver diseases were retrospectively reviewed, including 146 with mild chronic hepatitis B infection (CHB-M), 146 with severe chronic hepatitis B infection (CHB-S), and 146 with acute-on-chronic liver failure (ACLF). Read More

    Acute-onset Autoimmune Hepatitis in a Young Woman with Type 1 Diabetes Mellitus.
    Intern Med 2018 Jan 11. Epub 2018 Jan 11.
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan.
    Autoimmune hepatitis (AIH) and type 1 diabetes mellitus (T1DM) are thought to be induced by autoimmunity, but their coexistence has rarely been reported. We herein report a case in which a patient with T1DM developed acute-onset AIH. A 26-year-old woman, who had been diagnosed with T1DM in childhood, was transferred to our hospital because of acute liver failure of unknown etiology. Read More

    Early Combination Therapy with Corticosteroid and Nucleoside Analogue Induces Rapid Resolution of Inflammation in Acute Liver Failure Due to Transient Hepatitis B Virus Infection.
    Intern Med 2018 Jan 11. Epub 2018 Jan 11.
    Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan.
    Objective Patients with acute hepatitis B sometimes develop acute liver failure (ALF), which has a poor prognosis. The efficacy of nucleoside analogue (NA) monotherapy for ALF due to transient hepatitis B virus infection (HBV-ALF) remains controversial. Further investigations are necessary in nations with a shortage of donor livers for liver transplantation. Read More

    Human liver organoids generated with single donor-derived multiple cells rescue mice from acute liver failure.
    Stem Cell Res Ther 2018 Jan 10;9(1). Epub 2018 Jan 10.
    Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, 236-0004, Japan.
    Background: Acute liver failure (ALF) is a life-threatening disease with a high mortality rate. However, there are limited treatments or devices available for ALF therapy. Here, we aimed to develop a new strategy for ALF treatment by transplanting functional liver organoids (LOs) generated from single donor-derived human induced pluripotent stem cell (hiPSC) endoderm, endothelial cells (ECs), and mesenchymal cells (MCs). Read More

    Directly injected native bone-marrow stem cells cannot incorporate into acetaminophen-induced liver injury.
    Biologicals 2018 Jan 6. Epub 2018 Jan 6.
    Cell-Based Therapies Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
    The paucity of liver donation highlights the use of cell-based strategies for end-stage liver failure. We recently showed that bone marrow-derived aggregates (BMDAs) can completely restore the hematopoietic system in gamma-irradiated mice. These aggregates are stem and progenitor cells in the bone marrow (BM), composed of both hematopoietic and non-hematopoietic lineages. Read More

    NACSELD Acute-on-Chronic Liver Failure (NACSELD-ACLF) Score Predicts 30-Day Survival in Hospitalized Patients with Cirrhosis.
    Hepatology 2018 Jan 8. Epub 2018 Jan 8.
    Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, USA.
    NACSELD (North American Consortium for the Study of End-Stage Liver Disease) definition of acute-on-chronic liver failure (NACSELD-ACLF) as ≥2 extra-hepatic organ failures has been proposed as a simple bedside tool to assess risk of mortality in hospitalized patients with cirrhosis. We validated NACSELD-ACLF's ability to predict 30-day survival (defined as in-hospital death or hospice discharge) in a separate multicenter prospectively enrolled cohort of both infected and uninfected hospitalized patients with cirrhosis. We utilized the NACSELD database of 14 tertiary care hepatology centers that prospectively enrolled non-elective hospitalized patients with cirrhosis (N=2675). Read More

    High intrapatient variability of tacrolimus exposure in the early period after liver transplantation is associated with poorer outcomes.
    Transplantation 2018 Jan 8. Epub 2018 Jan 8.
    INSERM, CIC 1414, F-35033 Rennes, France.
    Background: Tacrolimus (TAC) is the cornerstone of immunosuppressive regimen in liver transplantation (LT). Its pharmacokinetics is characterized by a high inter- and intrapatient variability leading to an unpredictable dose-response relationship. The aim of our study was to evaluate the impact of TAC intrapatient variability (IPV) on graft and patient outcomes after liver transplantation. Read More

    Elderly donor graft for liver transplantation: Never too late.
    World J Transplant 2017 Dec;7(6):324-328
    Division of Gastroenterology and Hepatology, Missouri University, Columbia, MO 65212, United States.
    The definitive treatment for end stage liver disease remains a liver transplant and hence livers are needed for these patients along with cases of acute fulminant liver failure. Hence livers are a scarce and highly valuable commodity in the current time. By extending the pool of donors to include the elderly livers, it allows for increased availability of donors and reduces the mortality that is associated with the waiting list itself. Read More

    Prognostic nomogram for acute-on-chronic hepatitis B liver failure.
    Oncotarget 2017 Dec 18;8(65):109772-109782. Epub 2017 Sep 18.
    Liver Research Center, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
    Background & Aims: To establish an effective prognostic nomogram for acute-on-chronic hepatitis B liver failure (ACHBLF).

    Materials And Methods: The nomogram was based on clinical data of 203 ACHBLF patients who admitted to the First Affiliated Hospital of Fujian Medical University from 2009 to 2014. The area under the receiver-operating characteristic curve (AUC) and calibration curve were carried out to verify the predictive accuracy ability of the nomogram. Read More

    Induction of renal artery hyperresponsiveness by alpha1-adrenoceptor in hepatorenal syndrome.
    Oncotarget 2017 Dec 25;8(65):109258-109270. Epub 2017 Nov 25.
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710061, China.
    Objective: To investigate the potential role of alpha1-adrenoceptor (α1-AR) in the pathogenesis of hepatorenal syndrome.

    Methods: Hepatorenal syndrome was induced in male rats by intraperitoneal injection of D-galactosamine and orally treatment with α1-AR antagonist tamsulosin. Hyperresponsiveness of the renal artery contraction was evaluated by the laser-Doppler flowmetry and multimyograph system, while renal blood flow (cortical and medullary perfusion) was simultaneously measured. Read More

    A novel dynamic model for predicting outcome in patients with hepatitis B virus related acute-on-chronic liver failure.
    Oncotarget 2017 Dec 14;8(65):108970-108980. Epub 2017 Nov 14.
    Department of Critical Care Medicine of Liver Disease, Beijing You-An Hospital, Capital Medical University, Beijing, China.
    Aim: It is challenging to predict the outcome of patients with hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF) through existing prognostic models. Our aim was to establish a novel dynamic model to improve the predictive efficiency of 30-day mortality in HBV-ACLF patients.

    Methods: 305 patients who were diagnosed as HBV-ACLF (derivation cohort, n=211; validation cohort, n=94) were included in this study. Read More

    Acute Variceal Bleeding: Does Octreotide Improve Outcomes in Patients with Different Functional Hepatic Reserve?
    Ann Hepatol 2018 January-February;17(1):125-133
    Servicio de Gastroenterología, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, México.
    Background: Current guidelines do not differentiate in the utilization of vasoactive drugs in patients with cirrhosis and acute variceal bleeding (AVB) depending on liver disease severity.

    Material And Methods: In this retrospective study, clinical outcomes in 100 patients receiving octreotide plus endoscopic therapy (ET) and 216 patients with ET alone were compared in terms of failure to control bleeding, in-hospital mortality, and transfusion requirements stratifying the results according to liver disease severity by Child-Pugh (CP) score and MELD.

    Results: In patients with CP-A or those with MELD < 10 octreotide was not associated with a better outcome compared to ET alone in terms of hospital mortality (CP-A: 0. Read More

    Risk and Prognosis of Acute Liver Injury Among Hospitalized Patients with Hemodynamic Instability: A Nationwide Analysis.
    Ann Hepatol 2018 January-February;17(1):119-124
    Division of Gastroenterology & Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Risk and Prognosis of Acute Liver Injury Among Hospitalized Patients with Hemodynamic Instability: A Nationwide Analysis Introduction and aim. Critically ill patients in states of circulatory failure are at risk of acute liver injury, from mild elevations in aminotransferases to substantial rises consistent with hypoxic hepatitis or "shock liver". The present study aims to quantify the national prevalence of acute liver injury in patients with hemodynamic instability, identify risk factors for its development, and determine predictors of mortality. Read More

    Recurrent biliary acute pancreatitis is frequent in a real-world setting.
    Dig Liver Dis 2017 Dec 19. Epub 2017 Dec 19.
    Digestive & Liver Disease Unit, S. Andrea Hospital, University "La Sapienza", Rome, Italy. Electronic address:
    Background: Data about recurrent acute pancreatitis (RAP) are limited.

    Aims: To evaluate the rate of RAP and associated factors.

    Methods: Single-centre prospective study of consecutive patients at first episode of acute pancreatitis (AP) being followed-up. Read More

    Fat burner-induced acute liver injury: Case series of four patients.
    Nutrition 2017 Nov 6. Epub 2017 Nov 6.
    Department of Gastroenterology and Hepatology, University Medical Center Ljubljana, Ljubljana, Slovenia.
    Dietary supplements known as "fat burners" are typically marketed with claims of increasing energy expenditure through alterations in fat metabolism. They are marketed as natural products and their use is thus perceived as a safe body weight reduction strategy. We report on five episodes of liver injury in four patients. Read More

    Glycome Patterns of Perfusate in Livers Before Transplantation Associate With Primary Non-function.
    Gastroenterology 2018 Jan 5. Epub 2018 Jan 5.
    Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium; Experimental laboratory of Hepatology, Ghent University, Belgium. Electronic address:
    Background & Aims: Primary non-function (PNF) is a rare complication after liver transplantation that requires urgent re-transplantation. PNF is associated with livers from extended-criteria donors. Clinical and biochemical factors have not been identified that reliably associate with graft function after liver transplantation. Read More

    Incidence and Outcomes for Patients With Cirrhosis Admitted to the United Kingdom Critical Care Units.
    Crit Care Med 2018 Jan 5. Epub 2018 Jan 5.
    Liver Intensive Therapy Unit, Institute of Liver Studies, King's College Hospital, Denmark Hill, London, United Kingdom.
    Objective: To assess the epidemiology and outcome of patients with cirrhosis following critical care unit admission.

    Design: Retrospective cohort study.

    Setting: Critical care units in England, Wales, and Northern Ireland participating in the U. Read More

    [Correlation between model for end-stage liver disease score and prognosis in mushroom poisoning patients: a multicenter clinical study].
    Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Jan;30(1):67-71
    Department of Emergency, the First Hospital of China Medical University, Shenyang 110001, Liaoning, China (Cai Q, Jia ZY, Dong XS, Liu Z); Department of Emergency, the Ninth People's Hospital of Shenyang, Shenyang 110024, Liaoning, China (Liu TM); Second Department of Medicine, Xiuyan Central People's Hospital, Anshan 114300, Liaoning, China (Zhang CW); Department of Emergency, Fushun Central Hospital, Fushun 113006, Liaoning, China (Hui ZG). Corresponding author: Liu Zhi, Email:
    Objective: To find out the clinical indicators related to prognosis in patients with acute mushroom poisoning, and approach its correlation with prognosis.

    Methods: Clinical data of patients with mushroom poisoning admitted to the First Hospital of China Medical University, the Ninth People's Hospital of Shenyang, Xiuyan Central People's Hospital, and Fushun Central Hospital from August 2015 to August 2017 were retrospectively analyzed. The biochemical indicators within 24 hours after admission, sequential organ failure assessment (SOFA) score, model for end-stage liver disease (MELD) score, whether plasmapheresis (PE) was carried out or not and 28-day prognosis of patients were collected. Read More

    Wernicke encephalopathy in a patient after liver transplantation: A case report.
    World J Gastroenterol 2017 Dec;23(47):8432-8436
    Organ Transplantation Center, The Second Xiang-ya Hospital, Central South University, Changsha 410011, Hunan Province, China.
    Wernicke encephalopathy (WE) is an acute neurological disorder resulting from vitamin B1 deficiency, which is common in chronic alcoholism and is rare in acute liver failure. So far, there are 2 cases of WE reported after liver transplantation. Here, we report a case of a 45-year-old nonalcoholic male patient who developed psychiatric and neurological disturbance 15 d after receiving orthotopic liver transplantation because of hepatitis B-related cirrhosis and portal hypertension. Read More

    Herbal and Dietary Supplement-induced Liver Injuries in the Spanish DILI Registry.
    Clin Gastroenterol Hepatol 2018 Jan 4. Epub 2018 Jan 4.
    Unidad de Gestión Clínica de Aparato Digestivo, Servicio de Farmacología Clínica, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, CIBERehd, Málaga, Spain.
    Background & Aims: There have been increasing reports of liver injury associated with use of herbal and dietary supplements, likely due to easy access to these products and beliefs among consumers that they are safer or more effective than conventional medications. We aimed to evaluate clinical features and outcomes of patients with herbal and dietary supplement-induced liver injuries included in the Spanish DILI Registry.

    Methods: We collected and analyzed data on demographic and clinical features, along with biochemical parameters, of 32 patients with herbal and dietary supplement-associated liver injury reported to the Spanish DILI registry from 1994 through 2016. Read More

    The first episode of spontaneous bacterial peritonitis is a threat event in children with end-stage liver disease.
    Eur J Gastroenterol Hepatol 2018 Jan 4. Epub 2018 Jan 4.
    Pediatric Liver Transplantation Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
    Objective: Studies on native liver survival (NLS) after the first episode of spontaneous bacterial peritonitis (SBP) are rare. Our objective was to evaluate NLS in children up to 1 year after SBP.

    Methods: A historical cohort study of 18 children followed after the first episode of SBP was conducted. Read More

    Stem cells transplantation in the treatment of patients with liver failure.
    Curr Stem Cell Res Ther 2018 Jan 5. Epub 2018 Jan 5.
    Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041. China.
    Background: Liver failure is life-threatening liver disease encompassing a severe acute deterioration of liver function. Emergency liver transplantation is the only curative treatment for liver failure, but is restricted by the severe shortage of organ donors. Stem cell, including embroyonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, hematopoietic stem cells and hepatic progenitor cells, have capacity to proliferate and differentiate and could be used in a variety of liver diseases including hereditary liver diseases, cirrhosis and liver failure. Read More

    Stratified alpha-fetoprotein pattern accurately predicts mortality in patients with acute-on-chronic hepatitis B liver failure.
    Expert Rev Gastroenterol Hepatol 2018 Jan 12:1-8. Epub 2018 Jan 12.
    a Department of Hepatology, Liver Research Center , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
    Background: Alpha-fetoprotein (AFP) has been shown to predict the prognosis of liver disease in several studies. This study aimed to evaluate the prognostic value of stratified AFP in patients with acute-on-chronic hepatitis B liver failure (ACHBLF).

    Methods: A total of 192 patients were included and AFP were categorized into quartiles. Read More

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