18,549 results match your criteria Acute Liver Failure


Predicting Renal Recovery After Dialysis-Requiring Acute Kidney Injury.

Kidney Int Rep 2019 Apr 28;4(4):571-581. Epub 2019 Jan 28.

Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.

Introduction: After dialysis-requiring acute kidney injury (AKI-D), recovery of sufficient kidney function to discontinue dialysis is an important clinical and patient-oriented outcome. Predicting the probability of recovery in individual patients is a common dilemma.

Methods: This cohort study examined all adult members of Kaiser Permanente Northern California who experienced AKI-D between January 2009 and September 2015 and had predicted inpatient mortality of <20%. Read More

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http://dx.doi.org/10.1016/j.ekir.2019.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451155PMC

A fatal hepatitis A virus with dengue fever co-infection.

Authors:
Gassem Gohal

IDCases 2019 12;15:e00522. Epub 2019 Mar 12.

Faculty of Medicine, Jazan University, Saudi Arabia.

We report the first pediatric fatal case of Hepatitis A virus (HAV) and dengue virus (DENV) co-infection. A 4-year-old boy who had a partial recovery of HAV infection but with subsequent DENV infection; the condition was complicated by acute fulminant hepatic failure, and death. The risk of DENV co-infection should be considered as cause of acute fulminant hepatic failure in pre-existing Hepatitis A infection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22142509193004
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http://dx.doi.org/10.1016/j.idcr.2019.e00522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441740PMC
March 2019
1 Read

Transcriptional profiling in the livers of rats after hypobaric hypoxia exposure.

PeerJ 2019 9;7:e6499. Epub 2019 Apr 9.

Laboratory of Translational Medicine, Chinese PLA General Hospital, Beijing, China.

Ascent to high altitude feels uncomfortable in part because of a decreased partial pressure of oxygen due to the decrease in barometric pressure. The molecular mechanisms causing injury in liver tissue after exposure to a hypoxic environment are widely unknown. The liver must physiologically and metabolically change to improve tolerance to altitude-induced hypoxia. Read More

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http://dx.doi.org/10.7717/peerj.6499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461035PMC

Characteristics of Nonpulmonary Organ Dysfunction at Onset of ARDS Based on the Berlin Definition.

Respir Care 2019 Apr 16. Epub 2019 Apr 16.

Department of Pulmonary and Critical Care Medicine, University of California, San Francisco at San Francisco General Hospital, San Francisco, California.

Background: The Berlin definition of ARDS does not account for nonpulmonary organ failure, which is a major determinant of outcome. We examined whether an increasing severity of hypoxemia across the Berlin definition classifications also corresponded with evidence of multiple organ dysfunction on the day of ARDS onset. We also examined the representation of major etiologies for ARDS across the Berlin definition classifications. Read More

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http://rc.rcjournal.com/lookup/doi/10.4187/respcare.06165
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http://dx.doi.org/10.4187/respcare.06165DOI Listing
April 2019
1 Read

Predisposing factors for hypoglycaemia in the emergency department.

J Int Med Res 2019 Apr 16:300060519842037. Epub 2019 Apr 16.

1 Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan.

Objective: Hypoglycaemia is a common complication of diabetes mellitus. Previous studies suggest that hypoglycaemic episodes may occur with other comorbidities, influencing the outcome of recovery. Recognising the predisposing factors for hypoglycaemic episodes in the emergency department is important. Read More

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http://dx.doi.org/10.1177/0300060519842037DOI Listing
April 2019
1 Read

The Proton Pump Inhibitor Lansoprazole Has Hepatoprotective Effects in In Vitro and In Vivo Rat Models of Acute Liver Injury.

Dig Dis Sci 2019 Apr 15. Epub 2019 Apr 15.

Department of Surgery, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.

Background/aims: The proton pump inhibitor lansoprazole (LPZ) is clinically used to reduce gastric acid secretion, but little is known about its possible hepatoprotective effects. This study aimed to investigate the hepatoprotective effects of LPZ and its potential mechanisms using in vitro and in vivo rat models of liver injury.

Methods: For the in vitro model of liver injury, primary cultured rat hepatocytes were treated with interleukin-1β in the presence or absence of LPZ. Read More

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http://dx.doi.org/10.1007/s10620-019-05622-6DOI Listing

Novel Mutation in GALT Gene in Galactosemia Patient with Group B Streptococcus Meningitis and Acute Liver Failure.

Medicina (Kaunas) 2019 Apr 4;55(4). Epub 2019 Apr 4.

Second Pediatric Clinic, Department of Mother and Child, University of Medicine and Pharmacy "Iuliu Hațieganu" Cluj-Napoca, 400012 Cluj-Napoca, Romania.

Classic galactosemia is an autosomal recessive disorder caused by the deficiency of the enzyme galactose-1-phosphate uridyltransferase (GALT) involved in galactose metabolism. Bacterial infections are a known cause of early morbidity and mortality in children with classic galactosemia. The most common agent is but in rare situations, other bacteria are incriminated. Read More

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http://dx.doi.org/10.3390/medicina55040091DOI Listing

Left Ventricular Longitudinal Contractility Predicts Acute-on-Chronic Liver Failure Development and Mortality After Transjugular Intrahepatic Portosystemic Shunt.

Hepatol Commun 2019 Mar 22;3(3):340-347. Epub 2019 Jan 22.

Department of Internal Medicine I University Clinic Bonn Bonn Germany.

Acute deterioration of liver cirrhosis (e.g., infections, acute-on-chronic liver failure [ACLF]) requires an increase in cardiac contractility. Read More

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http://dx.doi.org/10.1002/hep4.1308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444053PMC

Clinical and demographic characteristics of geriatric patients with acute poisoning in the state of Uttarakhand.

J Family Med Prim Care 2019 Feb;8(2):443-448

Department of Emergency Medicine, AIIMS Rishikesh Campus, Uttrakhand, India.

Background: Acute poisoning in geriatric age group is a clinical challenge due to multiple comorbidities and complications in this age group. There are very few studies done in the past, which have addressed this issue.

Materials And Methods: This retrospective observational study was a carried out in the Department of Emergency Medicine of a tertiary care hospital of Uttarakhand over a period of 1 year from November 2017 to October 2018. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_420_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436262PMC
February 2019

Mortality pattern of elderly patients at a tertiary care hospital: A study from Sub-Himalayan region, Uttarakhand, India.

J Family Med Prim Care 2019 Feb;8(2):426-431

Department of Paediatrics, Government Doon Medical College, Dehradoon, Uttarakhand, India.

Background: Currently, in developing countries like India, there is a paradigm shift in the mortality patterns of elderly from communicable to noncommunicable diseases.

Objective: This study is aimed at providing an insight on mortality patterns of elderly patients within a 2-year period in a tertiary hospital, All India Institute of Medical Sciences (AIIMS), Rishikesh, India.

Materials And Methods: This study is a retrospective review of mortality patterns of elderly patients from March 2016 to March 2018 occurring in the Department of General Medicine, in AIIMS, Rishikesh, India. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_416_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436249PMC
February 2019

Case Report: Levetiracetam causing acute liver failure complicating post-operative management in a neurosurgical patient.

F1000Res 2019 15;8:187. Epub 2019 Feb 15.

Department of Neurosurgery, Nobel Medical College and Teaching Hospital, Biratnagar, 0977, Nepal.

 Herein we report a rare case of acute liver failure due to levetiracetam, which has been considered to have an excellent safety profile with minimal hepatic side effects.  A 55-year-old male patient presenting with sudden onset dizziness, slurring of speech and headache was operated for posterior fossa cerebellar hematoma. His post-surgical period was complicated by development of icterus with elevation of liver enzymes. Read More

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https://f1000research.com/articles/8-187/v1
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http://dx.doi.org/10.12688/f1000research.18198.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446496PMC
February 2019
1 Read

Infections in Cirrhosis.

Curr Treat Options Gastroenterol 2019 Apr 12. Epub 2019 Apr 12.

Division of Gastroenterology and Hepatology, University of Pennsylvania, 2 Dulles, 3400 Spruce Street, HUP, Philadelphia, PA, 19104, USA.

Purpose Of Review: Patients with cirrhosis are at high risk of developing serious infections. Bacterial infections remain the most common cause of morbidity and mortality in these patients. This review is focused on the prevalence of infections in those with cirrhosis, including multidrug-resistant (MDR) pathogens, pathogenesis of infection-related acute-on-chronic liver failure (ACLF), current treatment recommendations, and prophylactic strategies in patients with cirrhosis. Read More

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http://dx.doi.org/10.1007/s11938-019-00229-2DOI Listing

HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen.

Sci Rep 2019 Apr 12;9(1):5971. Epub 2019 Apr 12.

Department of Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.

Acetaminophen (APAP) overdose (APAPo) is predominant in the NIH Pediatric Acute Liver Failure (PALF) Study. We assayed multiple inflammatory mediators in serial serum samples from 13 PALF survivors with APAPo + N-acetylcysteine (NAC, the frontline therapy for APAPo), 8 non-APAPo + NAC, 40 non-APAPo non-NAC, and 12 non-survivors. High Mobility Group Box 1 (HMGB1) was a dominant mediator in dynamic inflammation networks in all sub-groups, associated with a threshold network complexity event at d1-2 following enrollment that was exceeded in non-survivors vs. Read More

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http://www.nature.com/articles/s41598-019-42564-5
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http://dx.doi.org/10.1038/s41598-019-42564-5DOI Listing
April 2019
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First case report of successful PCI with thrombocytopenia treated with partial splenic artery embolization.

Cardiovasc Revasc Med 2019 Mar 31. Epub 2019 Mar 31.

Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.

Percutaneous coronary intervention (PCI) for patients with thrombocytopenia presents a difficult problem in that dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation is not suitable. This first case report describes our patient with angina pectoris and thrombocytopenia who we successfully treated with PCI after partial splenic artery embolization (PSE). A 70-year-old Japanese male was transferred to our hospital because of acute decompensated heart failure (ADHF). Read More

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http://dx.doi.org/10.1016/j.carrev.2019.03.022DOI Listing

Value of Model for End-Stage Liver Disease-Serum Sodium Scores in Predicting Complication Severity Grades After Liver Transplantation for Acute-on-chronic Liver Failure.

Authors:
Q-K Zhang M-L Wang

Transplant Proc 2019 Apr 9;51(3):833-841. Epub 2019 Jan 9.

General Surgical Center, Beijing You-An Hospital, Capital Medical University, Beijing, China. Electronic address:

Background: Preoperative evaluation is extremely important for patients undergoing liver transplantation (LT) for acute-on-chronic liver failure (ACLF). It is unclear that whether preoperative Model for End-Stage Liver Disease-Serum Sodium (MELD-Na) score has a decisive effect on the complication grade after LF for ACLF. This study is aimed to explore the value of preoperative MELD-Na scores in predicting complication severity grades post LT for ACLF. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.027DOI Listing

Protective properties of the cultured stem cell proteome studied in an animal model of acetaminophen-induced acute liver failure.

Mol Biol Rep 2019 Apr 12. Epub 2019 Apr 12.

Institute of Science and Technology (IST Austria), Klosterneuburg, Austria.

Chronic overuse of common pharmaceuticals, e.g. acetaminophen (paracetamol), often leads to the development of acute liver failure (ALF). Read More

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http://link.springer.com/10.1007/s11033-019-04765-z
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http://dx.doi.org/10.1007/s11033-019-04765-zDOI Listing
April 2019
2 Reads

Prothrombin Complex Concentrates for Coagulopathy in Liver Disease: Single-Center, Clinical Experience in 105 Patients.

Hepatol Commun 2019 Apr 5;3(4):513-524. Epub 2019 Feb 5.

Katharine Dormandy Haemophilia and Thrombosis Centre Royal Free Hospital London United Kingdom.

Patients with liver disease frequently develop coagulopathy, and fresh frozen plasma is traditionally used for correction of coagulopathy to manage and prevent bleeding. Prothrombin complex concentrates (PCCs) offer an attractive alternative because they are more readily available and avoid large-volume transfusion. This retrospective, single-center study reviewed clinical use of PCC in patients with acute/chronic liver disease. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hep4.1293
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http://dx.doi.org/10.1002/hep4.1293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442702PMC
April 2019
8 Reads

Leukocyte cell derived chemotaxin-2 (Lect2) as a predictor of survival in adult acute liver failure.

Transl Gastroenterol Hepatol 2019 20;4:17. Epub 2019 Mar 20.

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.

Background: One of the major issues in the field of acute liver failure (ALF) is the lack of reliable biomarkers that predict outcome. Many cases present with very limited treatment options and prognostic indicators are invaluable. We tested whether leukocyte cell derived chemotaxin 2 can be used as a prognostic biomarker to predict patient survival either alone or in combination with other routine clinical parameters. Read More

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http://dx.doi.org/10.21037/tgh.2019.03.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458334PMC
March 2019
1 Read

Acute liver failure associated with Fructus Psoraleae: a case report and literature review.

BMC Complement Altern Med 2019 Apr 11;19(1):84. Epub 2019 Apr 11.

Department of Dermatology, Qianfoshan Hospital, Shandong University, 16766 Jing-Shi Road, Jinan, 250014, China.

Background: Fructus Psoraleae is the seed of Psoralea corylifolia Linn. Fructus Psoraleae has been shown to be effective in treating some skin diseases, such as vitiligo. As a main ingredient in five types of herbs in the Qubaibabuqi tablet formula, Fructus Psoraleae plays an important role in the treatment of vitiligo. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-019-2493-9DOI Listing
April 2019
2 Reads

Serum keratin-18 fragments as cell death biomarker in association with disease progression and prognosis in HBV-related cirrhosis.

J Viral Hepat 2019 Apr 11. Epub 2019 Apr 11.

Department of Infectious Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Extensive hepatocyte death leads to hepatic inflammation and contributes to systemic inflammation in decompensated cirrhosis. We aimed to investigate the prognostic value of serum cell death markers in patients with Hepatitis B virus (HBV)-related acute decompensation (AD) of cirrhosis with and without acute-on-chronic liver failure (ACLF). We studied two cohorts - cohort 1: 201 outpatients with stable chronic hepatitis B (49 cirrhosis); cohort 2: 232 inpatients with HBV-related cirrhosis admitted for AD. Read More

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http://dx.doi.org/10.1111/jvh.13100DOI Listing
April 2019
3 Reads

Identifying Factors That Affect Patient Survival After Orthotopic Liver Transplant Using Machine-Learning Techniques.

Exp Clin Transplant 2019 Apr 9. Epub 2019 Apr 9.

From the Student Research Committee, School of Management and Medical Information Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Objectives: Survival after liver transplant depends on pretransplant, peritransplant, and posttransplant factors. Identifying effective factors for patient survival after transplant can help transplant centers make better decisions.

Materials And Methods: Our study included 902 adults who received livers from deceased donors from March 2011 to March 2014 at the Shiraz Organ Transplant Center (Shiraz, Iran). Read More

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http://dx.doi.org/10.6002/ect.2018.0170DOI Listing
April 2019
1 Read

Liver involvement in the drug reaction, eosinophilia, and systemic symptoms syndrome.

World J Clin Cases 2019 Mar;7(6):705-716

Department of Medicine, Division of Gastroenterology, University of Calgary, Calgary, Alberta T2N 4Z6, Canada.

First described in 1996, the drug reaction, eosinophilia, and systemic symptoms syndrome (DReSS) is considered, along with Stevens-Johnson syndrome and toxic epidermal necrolysis, a severe cutaneous drug reaction. It is characterized by the presence of a maculopapular erythematous skin eruption, fever, lymphadenopathy, influenza-like symptoms, eosinophilia, and visceral involvement such as hepatitis, pneumonitis, myocarditis, pericarditis, nephritis, and colitis. The prognosis of patients with DReSS is related to the severity of visceral involvement. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i6.705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448072PMC
March 2019
2 Reads

Protective action of glutamine in rats with severe acute liver failure.

World J Hepatol 2019 Mar;11(3):273-286

Laboratory of Experimental Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre, Porto Alegre 90040060, Brazil.

Background: Severe acute liver failure (SALF) is a rare, but high-mortality, rapidly evolving syndrome that leads to hepatocyte degeneration with impaired liver function. Thioacetamide (TAA) is a known xenobiotic, which promotes the increase of the formation of reactive oxygen species. Erythroid 2-related factor 2 (Nrf2) activates the antioxidant protection of cells. Read More

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http://dx.doi.org/10.4254/wjh.v11.i3.273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447424PMC
March 2019
2 Reads

Combined liver-kidney transplantation; two for the price of one?

Transpl Int 2019 Apr 8. Epub 2019 Apr 8.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, Netherlands.

In 1983 the first combined liver and kidney transplantation (CLKT) was performed by Margreiter et al and the first CLKT from a living related donor was carried out in Turkey in 1992. The indications for CLKT can be divided into three categories: I) end-stage liver disease with chronic kidney failure, II) end-stage liver disease with acute kidney failure, and III) metabolic disorders. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/tri.13438DOI Listing
April 2019
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Multi-organ failure induced by Nivolumab in the context of allo-stem cell transplantation.

Exp Hematol Oncol 2019 28;8. Epub 2019 Mar 28.

1Institute for Advanced Biosciences, Université Grenoble Alpes, INSERM 1209, UMR CNRS 5309, Grenoble, France.

Background: Immune checkpoint inhibitors have radically changed the landscape of anti-tumor therapies in several malignancies. However the adverse events associated with immune checkpoint blockade in combination with other treatments remains to be thoroughly documented. Here we report the case of a 33-year-old male with classical Hodgkin lymphoma who was successfully treated for lymphoma but experienced serious and eventually fatal multisystem organ failure following nivolumab administration and allogeneic stem cell transplantation. Read More

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http://dx.doi.org/10.1186/s40164-019-0132-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437980PMC
March 2019
1 Read

Acute Renal Failure of Nosocomial Origin.

Dtsch Arztebl Int 2019 Mar;116(9):149-158

Background: 10-20% of hospitalized patients develop acute kidney injury (AKI)/acute renal failure during their hospital stay. The mortality of nosocomial AKI is approximately 30%.

Methods: This review is based on relevant publications retrieved by a search in multiple databases (PubMed and Uptodate), archives, and pertinent medical journals. Read More

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http://dx.doi.org/10.3238/arztebl.2019.0149DOI Listing
March 2019
1 Read

Generation of an induced pluripotent stem cell (iPSC) line, DHMCi005-A, from a patient with CALFAN syndrome due to mutations in SCYL1.

Stem Cell Res 2019 Mar 22;37:101428. Epub 2019 Mar 22.

Centre for Child and Adolescent Medicine, Department of General Pediatrics, Division of Neuropediatrics and Metabolic Medicine, University Hospital Heidelberg, 69120 Heidelberg, Germany. Electronic address:

Variants in SCYL1 can cause a syndrome with low γ-glutamyl-transferase cholestasis, acute liver failure, and neurodegeneration (CALFAN). The encoded protein is involved in intracellular trafficking between Golgi and ER, specific mechanisms are still to be elucidated. We reprogrammed fibroblasts of a 2 years old male patient with CALFAN Syndrome due to a homozygous nonsense variant in SCYL1 (c. Read More

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http://dx.doi.org/10.1016/j.scr.2019.101428DOI Listing
March 2019
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Deteriorated Outcome of Recent Patients with Acute Liver Failure and Late-Onset Hepatic Failure Caused by Infection with Hepatitis A Virus: A Subanalysis of Patients Seen Between 1998 and 2015 and Enrolled in Nationwide Surveys in Japan.

Hepatol Res 2019 Apr 7. Epub 2019 Apr 7.

Department of Gastroenterology & Hepatology, Saitama Medical University.

Aim: A nationwide survey of acute liver failure (ALF) and late-onset hepatic failure (LOHF) has revealed that the outcomes of recent patients whose diseases were caused by infection with hepatitis A virus (HAV) have worsened, compared with those of previously reported patients. Here, the factors associated with this deterioration were evaluated.

Methods: A total of 83 patients with HAV infection seen between 1998 and 2015 were enrolled. Read More

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http://dx.doi.org/10.1111/hepr.13345DOI Listing
April 2019
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Transcranial Doppler Non-invasive Assessment of Intracranial Pressure, Autoregulation of Cerebral Blood Flow and Critical Closing Pressure during Orthotopic Liver Transplant.

Ultrasound Med Biol 2019 Apr 2. Epub 2019 Apr 2.

Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom; Institute of Electronic Systems, Warsaw University of Technology, Warsaw, Poland.

Transcranial Doppler (TCD) ultrasonography allows continuous non-invasive monitoring of cerebral blood flow velocity in a variety of clinical conditions. Recently, signal processing of TCD signals has provided several comprehensive parameters for the assessment of cerebral haemodynamics. In this work, we applied a TCD multimodal approach in patients with acute liver failure undergoing orthotopic liver transplant (OLT) to assess the clinical feasibility of using TCD for cerebral haemodynamics assessment in this setting. Read More

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http://dx.doi.org/10.1016/j.ultrasmedbio.2019.02.003DOI Listing
April 2019
2 Reads

Hepatobiliary Complications in Critically Ill Patients.

Clin Liver Dis 2019 May 8;23(2):221-232. Epub 2019 Mar 8.

Division of Gastroenterology and Hepatology, Northwestern Feinberg School of Medicine, 19-046 Arkes Building, 676 North Saint Clair, Chicago, IL 60611, USA.

Critically ill patients frequently present with the systemic inflammatory response syndrome, which is largely a reflection of the liver's response to injury. Underlying hepatic congestion is a major risk factor for hypoxic liver injury, the most common cause for hepatocellular injury. Cholestatic liver injury often occurs in critically ill patients due to inhibition of farnesoid X receptor (FXR), the main regulator of bile acid handling, particularly in the liver and intestines. Read More

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http://dx.doi.org/10.1016/j.cld.2018.12.005DOI Listing

The Liver in Sickle Cell Disease.

Clin Liver Dis 2019 May 21;23(2):177-189. Epub 2019 Feb 21.

Institute of Liver Studies, King's College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK. Electronic address:

Patients with sickle cell disease can develop liver disease as a result of intrahepatic sickling of erythrocytes, viral hepatitis and iron overload secondary to multiple blood transfusions, and gallstone disease as a result of chronic hemolysis. The spectrum of clinical liver disease is wide and often multifactorial. Some patients develop cirrhosis that may progress to end-stage liver failure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10893261183010
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http://dx.doi.org/10.1016/j.cld.2018.12.002DOI Listing
May 2019
3 Reads

Acute heart failure in rabbits by avocado leaf poisoning.

Toxicon 2019 Apr 1;164:16-19. Epub 2019 Apr 1.

Facultad de Ciencias Agrarias y Veterinarias-UCASAL, INTA EEA Salta, RN 68 Km 172, 4403, Cerrillos, Salta, Argentina; Grupo de Trabajo de Patología, Epidemiología e Investigación Diagnóstica, Área de Sanidad Animal-IIACS Salta/INTA, INTA EEA Salta, RN 68 Km 172, 4403, Cerrillos, Salta, Argentina. Electronic address:

The aim of this paper was to report an outbreak of avocado poisoning in rabbits in Salta, Argentina. Fourteen rabbits died of congestive heart failure within 30 h of ingesting fresh avocado leaves from pruned trees. They showed clinical signs of respiratory and cardiac distress. Read More

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http://dx.doi.org/10.1016/j.toxicon.2019.03.024DOI Listing
April 2019
2 Reads

The Utility of ECMO After Liver Transplantation: Experience at a High-Volume Transplant Center and Review of the Literature.

Transplantation 2019 Apr 1. Epub 2019 Apr 1.

Introduction: Extra-corporeal membrane oxygenation (ECMO) artificially supports respiratory and/or cardiac function when conventional techniques fail. ECMO has been described as a treatment modality for acute pulmonary and/or cardiac failure following orthotopic liver transplantation (OLT). Here we present a series of adult OLT recipients placed on ECMO after transplantation for both respiratory and cardiac indications and review the literature on the role of ECMO in the setting of OLT. Read More

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http://dx.doi.org/10.1097/TP.0000000000002716DOI Listing
April 2019
3 Reads

An unexpected role of cholesterol sulfotransferase and its regulation in sensitizing mice to acetaminophen induced liver injury.

Mol Pharmacol 2019 Apr 3. Epub 2019 Apr 3.

University of Pittsburgh

Overdose of acetaminophen (APAP) is the leading cause of acute liver failure (ALF) in the United States. The sulfotransferase-mediated sulfation of APAP is widely believed to be a protective mechanism to attenuate the hepatotoxicity of APAP. The cholesterol sulfotransferase SULT2B1b is best known for its activity in catalyzing the sulfoconjugation of cholesterol to synthesize cholesterol sulfate. Read More

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http://dx.doi.org/10.1124/mol.118.114819DOI Listing
April 2019
3 Reads

Evaluating the best empirical antibiotic therapy in patients with acute-on-chronic liver failure and spontaneous bacterial peritonitis.

Dig Liver Dis 2019 Mar 31. Epub 2019 Mar 31.

Department of Medicine II, University Hospital, LMU Munich, Germany. Electronic address:

Background/aims: Spontaneous bacterial peritonitis (SBP) is a life-threatening complication of advanced cirrhosis. By studying the susceptibility of isolated organisms and analyzing empirical antibiotic therapy combined with clinical outcomes, we aimed to find an improved empirical antibiotic therapy by considering the individual acute-on-chronic liver failure (ACLF) grade for patients with or without sepsis.

Methods: Clinical outcomes of 182 patients were assessed retrospectively with multivariable regression analysis. Read More

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http://dx.doi.org/10.1016/j.dld.2019.02.015DOI Listing
March 2019
1 Read

Addressing Profiles of Systemic Inflammation Across the Different Clinical Phenotypes of Acutely Decompensated Cirrhosis.

Front Immunol 2019 19;10:476. Epub 2019 Mar 19.

European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain.

Patients with acutely decompensated cirrhosis (AD) may or may not develop acute-on-chronic liver failure (ACLF). ACLF is characterized by high-grade systemic inflammation, organ failures (OF) and high short-term mortality. Although patients with AD cirrhosis exhibit distinct clinical phenotypes at baseline, they have low short-term mortality, unless ACLF develops during follow-up. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00476
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http://dx.doi.org/10.3389/fimmu.2019.00476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434999PMC
March 2019
2 Reads

Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice.

J Neuroinflammation 2019 Apr 2;16(1):69. Epub 2019 Apr 2.

Central Texas Veterans Health Care System, Temple, TX, USA.

Background: Acute liver failure resulting from drug-induced liver injury can lead to the development of neurological complications called hepatic encephalopathy (HE). Hepatic transforming growth factor beta 1 (TGFβ1) is upregulated due to liver failure in mice and inhibiting circulating TGFβ reduced HE progression. However, the specific contributions of TGFβ1 on brain cell populations and neuroinflammation during HE are not known. Read More

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http://dx.doi.org/10.1186/s12974-019-1455-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446280PMC
April 2019
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Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt.

Clin Transl Gastroenterol 2019 Mar 29. Epub 2019 Mar 29.

Department of Internal Medicine I, University of Bonn, Bonn, Germany.

Introduction: Muscle mass has been shown to be a prognostic marker in patients with liver cirrhosis. Transversal psoas muscle thickness normalized by height (TPMT/height) obtained by routine computed tomography is a simple surrogate parameter for sarcopenia. TPMT/height, however, is not sex specific, which might play a role in risk stratification. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000025DOI Listing
March 2019
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Downregulation of microRNA-214 improves therapeutic potential of allogeneic bone marrow-derived mesenchymal stem cell by targeting PIM-1 in rats with acute liver failure.

J Cell Biochem 2019 Apr 2. Epub 2019 Apr 2.

Department of Gastroenterology and Hepatology, The Third People's Hospital of Yunnan Province, Kunming, People's Republic of China.

Acute liver failure (ALF) is a disease resulted from diverse etiology, which generally leads to a rapid degenerated hepatic function. However, transplantation bone marrow-derived mesenchymal stem cells (BMSCs) transplantation has been suggested to relieve ALF. Interestingly, microRNA-214 (miR-214) could potentially regulate differentiation and migration of BMSCs. Read More

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http://dx.doi.org/10.1002/jcb.28560DOI Listing
April 2019
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Characteristics, Risk Factors, and Adverse Outcomes of Hyperkalemia in Acute-on-Chronic Liver Failure Patients.

Biomed Res Int 2019 27;2019:6025726. Epub 2019 Feb 27.

Department of Hepatology, Tianjin Third Central Hospital, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Tianjin, China.

Background: Hyperkalemia is a serious complication in cirrhotic patients. However, the clinical characteristics, risk factors, and its impact on the outcomes in acute-on-chronic liver failure (ACLF) patients remain unclear.

Methods: We retrospectively recruited 650 ACLF patients in this study. Read More

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http://dx.doi.org/10.1155/2019/6025726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415283PMC
February 2019
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Ocular infiltration as initial presentation of acute monocytic leukaemia transformed from chronic myelomonocytic leukaemia associated with V600E mutation.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Department of Clinical Haematology, Monash Health, Clayton, Victoria, Australia.

Acute monocytic leukaemia (French-British-American classification: AML-M5b) is characterised by a predominance of cells of the monocytic lineage on bone marrow examination. Furthermore, a discerning feature is its tendency for tissue infiltration. While gum hypertrophy and hepatosplenomegaly are common, ocular involvement is rare. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22851
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http://dx.doi.org/10.1136/bcr-2018-228519DOI Listing
March 2019
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Surviving Acute Organ Failure: Cell Polyploidization and Progenitor Proliferation.

Trends Mol Med 2019 Mar 26. Epub 2019 Mar 26.

Department of Biological and Experimental Medical Science 'Mario Serio', Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies (DENOTHE); Meyer Children's Hospital, Florence, Italy. Electronic address: http://www.twitter.com/PRomagnani.

In acute organ failure, rapid compensation of function loss assures survival. Dedifferentiation and/or proliferation of surviving parenchymal cells could imply a transient (and potentially fatal) impairment of residual functional performance. However, evolution has selected two flexible life-saving mechanisms acting synergistically on organ function recovery. Read More

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http://dx.doi.org/10.1016/j.molmed.2019.02.006DOI Listing
March 2019
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Proton beam therapy outcomes for localized unresectable hepatocellular carcinoma.

Radiother Oncol 2019 Apr 16;133:54-61. Epub 2019 Jan 16.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, United States. Electronic address:

Background And Purpose: This study documents the utilization and efficacy of proton beam therapy (PBT) in western patients with localized unresectable hepatocellular carcinoma (HCC).

Methods And Methods: Forty-six patients with HCC, Child-Pugh class of A or B, no prior radiotherapy history, and ECOG performance status 0-2 received PBT at our institution from 2007 to 2016. Radiographic control within the PBT field (local control, LC) and overall survival (OS) were calculated from the start of PBT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01678140183367
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http://dx.doi.org/10.1016/j.radonc.2018.10.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446916PMC
April 2019
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[Acute fatty liver in pregnancy].

Ugeskr Laeger 2019 Mar;181(12)

This case report of a 31-year-old primiparous woman discusses the importance of early diagnosis and treatment of acute fatty liver in pregnancy (AFLP) to prevent maternal or/and foetal death. AFLP is a rare disease, which is characterised by maternal liver dysfunction and/or failure. Because of similar symptoms and laboratory findings AFLP may mimic and is often mistaken for 1) the more frequent HELLP syndrome with haemolysis, elevated liver enzymes and low platelet levels and 2) and severe pre-eclampsia. Read More

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March 2019
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Liver CEBPβ Modulates the Kynurenine Metabolism and Mediates the Motility for Hypoxia-Induced Central Fatigue in Mice.

Front Physiol 2019 14;10:243. Epub 2019 Mar 14.

Department of Cold Environment Medicine, College of High Altitude Military Medicine, Third Military Medical University and Key Laboratory of High Altitude Medicine, Ministry of Education, Key Laboratory of High Altitude Medicine, PLA, Chongqing, China.

Central fatigue is defined as a failure of the central nervous system to adequately drive the muscle, manifesting limited development, and maintenance of locomotor activity. A plateau in hypoxia leads to central fatigue and followed by maximal motility recession. However, the underlying mechanism is still unclear. Read More

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http://dx.doi.org/10.3389/fphys.2019.00243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428026PMC
March 2019
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Kinetic deterioration of short memory in rat with acute hepatic encephalopathy: Involvement of astroglial and neuronal dysfunctions.

Behav Brain Res 2019 Mar 27;367:201-209. Epub 2019 Mar 27.

Neuroscience, Pharmacology and Environment Unit (ENPE), faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech, Morocco. Electronic address:

Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome resulting from acute or chronic hepatic impairments. The clinical features of HE include attention as well as a mild cognitive deficits associated with impaired attentional and executive networks in patients as well as in animal models of HE. The underlining pathomechanism of memory impairment in HE patients is still not fully understood; however, it may involve a possible gliopathy as well as neuropathy. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.046DOI Listing
March 2019
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Risks and outcomes of allogeneic hematopoietic stem cell transplantation for hematologic malignancies in patients with Human immunodeficiency virus Infection.

Biol Blood Marrow Transplant 2019 Mar 26. Epub 2019 Mar 26.

Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN; Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, SA. Electronic address:

Allogeneic hematopoietic cell transplantation (Allo-HCT) is a potentially curative therapy for hematologic malignancies in persons living with human immunodeficiency virus (PLHIV), however, uncertainties exist in many domains related to their care, including optimal donor selection, conditioning regimen, immunosuppression for graft-versus-host disease (GVHD) and long-term outcomes. We undertook a comprehensive systematic review from multiple databases to evaluate the above-mentioned uncertainties. Forty-nine patients (median age 34 years at HCT) were included in the final sample size. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.03.021DOI Listing
March 2019
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EASL Clinical Practice Guidelines: Drug-induced liver injury.

Authors:

J Hepatol 2019 Mar 27. Epub 2019 Mar 27.

Idiosyncratic (unpredictable) drug-induced liver injury is one of the most challenging liver disorders faced by hepatologists, because of the myriad of drugs used in clinical practice, available herbs and dietary supplements with hepatotoxic potential, the ability of the condition to present with a variety of clinical and pathological phenotypes and the current absence of specific biomarkers. This makes the diagnosis of drug-induced liver injury an uncertain process, requiring a high degree of awareness of the condition and the careful exclusion of alternative aetiologies of liver disease. Idiosyncratic hepatotoxicity can be severe, leading to a particularly serious variety of acute liver failure for which no effective therapy has yet been developed. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.02.014DOI Listing
March 2019
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The microbiome: implications for perioperative and critical care.

Curr Opin Anaesthesiol 2019 Mar 28. Epub 2019 Mar 28.

Division of Digestive and Liver Diseases, Department of Medicine.

Purpose Of Review: The host-microbiota relationship is integral in human health and can be rapidly disrupted in ways that may contribute to poor recovery from surgery or acute illness. We review key studies by organ system to understand the effect of perioperative and critical illness stress on the microbiota. Throughout the review, our focus is on potential interventions that may be mediated by the microbiome. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000734DOI Listing
March 2019
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