Minerva Gastroenterol (Torino) 2021 May 12. Epub 2021 May 12.
Division of Gastroenterology and Hepatology, Città della Salute e della Scienza, Molinette Hospital, University of Turin, Turin, Italy -
Background: Adult-onset Still's Disease (AOSD) is a systemic inflammatory condition, mainly characterized by high spiking fevers, leukocytosis, skin rash, arthralgia and myalgia. Liver involvement is a frequent feature, usually presenting with hepatomegaly and mild liver enzymes abnormalities, which usually normalize after treatment with anti-inflammatory or immunomodulatory drugs given for AOSD. Although uncommon, the onset of severe acute hepatitis and even of life-threatening liver failure is possible and requires a prompt diagnosis and an aggressive therapy and, in some cases, an emergency liver transplantation. Read More