Search our Database of Scientific Publications and Authors

I’m looking for a

    16203 results match your criteria Acute Liver Failure

    1 OF 325

    Probiotics for people with hepatic encephalopathy.
    Cochrane Database Syst Rev 2017 Feb 23;2:CD008716. Epub 2017 Feb 23.
    Sydney School of Public Health, The University of Sydney, Edward Ford Building A27, Sydney, NSW, Australia, 2006.
    Background: Hepatic encephalopathy is a disorder of brain function as a result of liver failure or portosystemic shunt or both. Both hepatic encephalopathy (clinically overt) and minimal hepatic encephalopathy (not clinically overt) significantly impair patient's quality of life and daily functioning, and represent a significant burden on healthcare resources. Probiotics are live micro-organisms, which when administered in adequate amounts, may confer a health benefit on the host. Read More

    Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis.
    Nutrients 2017 Feb 20;9(2). Epub 2017 Feb 20.
    Department of Animal Biology, Faculty of Science, University of Malaga, Campus de Teatinos s/n Malaga 29071, Spain and Andalusian Center for Nanomedicine and Biotechnology (BIONAND), Severo Ochoa 25, Campanillas 29590, Spain.
    Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being necessary for adult tissue homeostasis. Vitamin A deficiency during pregnancy increases risk of maternal night blindness and anemia and may be a cause of congenital malformations. Read More

    Genistein Alleviates Neuroinflammation and Restores Cognitive Function in Rat Model of Hepatic Encephalopathy: Underlying Mechanisms.
    Mol Neurobiol 2017 Feb 21. Epub 2017 Feb 21.
    Department of Biotechnology, Jamia Millia Islamia, New Delhi, India.
    Hepatic encephalopathy (HE) is a neuropsychiatric syndrome resulting from acute liver failure. Previously, we demonstrated hepatoprotective effects of genistein in D-galactosamine (D-GalN)-induced fulminant hepatic failure (FHF). In this study, we evaluated behavioural and neuroprotective effects of genistein in rat model of HE. Read More

    Prodromal fever indicates high risk of liver failure in acute hepatitis B.
    Int J Infect Dis 2017 Feb 18. Epub 2017 Feb 18.
    Division of Liver Diseases, Jinan Infectious Disease Hospital, Shandong University, Jinan, China. Electronic address:
    Objectives: The role of prodromal fever in the clinical course of acute hepatitis B virus (HBV) infection is still largely unclear. This study was conducted to investigate the factors associated with prodromal fever and its role on the developing of acute liver failure (ALF) in patients with acute hepatitis B (AHB).

    Methods: AHB inpatients diagnosed between January 2006 and December 2010 were evaluated and followed. Read More

    Comparison of the prognostic value of Chronic Liver Failure Consortium scores and traditional models for predicting mortality in patients with cirrhosis.
    Gastroenterol Hepatol 2017 Feb 17. Epub 2017 Feb 17.
    Gastroenterology Department, Centro Hospitalar do Algarve, Rua Leão Penedo, 8000-386 Faro, Portugal.
    Background And Aim: Recently, the European Association for the Study of the Liver - Chronic Liver Failure (CLIF) Consortium defined two new prognostic scores, according to the presence or absence of acute-on-chronic liver failure (ACLF): the CLIF Consortium ACLF score (CLIF-C ACLFs) and the CLIF-C Acute Decompensation score (CLIF-C ADs). We sought to compare their accuracy in predicting 30- and 90-day mortality with some of the existing models: Child-Turcotte-Pugh (CTP), Model for End-Stage Liver Disease (MELD), MELD-Na, integrated MELD (iMELD), MELD to serum sodium ratio index (MESO), Refit MELD and Refit MELD-Na.

    Methods: Retrospective cohort study that evaluated all admissions due to decompensated cirrhosis in 2 centers between 2011 and 2014. Read More

    Acute Liver Failure During Deferasirox Chelation: A Toxicity Worth Considering.
    J Pediatr Hematol Oncol 2017 Feb 17. Epub 2017 Feb 17.
    Divisions of *Pediatric Hematology/Oncology †Genetics, Albany Medical Center ‡Department of Emergency Medicine, St Peter's Hospital, Albany, NY.
    This case report details a unique case of acute, reversible liver failure in a 12-year-old male with sickle cell anemia on chronic transfusion protocol and deferasirox chelation. There is substantial literature documenting deferasirox-induced renal injury, including Fanconi syndrome, but less documentation of hepatic toxicity and few reports of hepatic failure. The case highlights the importance of close monitoring of ferritin, bilirubin, and transaminases for patients on deferasirox. Read More

    Living donor liver transplantation during the first three months of life.
    Liver Transpl 2017 Feb 21. Epub 2017 Feb 21.
    Organ Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
    Background: Living donor liver transplantation is now an established technique for treating children with end-stage liver disease. Few data exist about liver transplantation for exclusively young infants, especially infants of <3 months of age. We report our single-center experience with 12 cases in which living donor liver transplantation (LT) was performed during the first 3 months of life and compare the results with those of older infants who underwent LT. Read More

    Proposal for a New Predictive Model of Short-Term Mortality After Living Donor Liver Transplantation due to Acute Liver Failure.
    Ann Transplant 2017 Feb 21;22:101-107. Epub 2017 Feb 21.
    Department of Obstetrics and Gynecology, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea, Seoul, South Korea.
    BACKGROUND Acute liver failure (ALF) is known to be a rapidly progressive and fatal disease. Various models which could help to estimate the post-transplant outcome for ALF have been developed; however, none of them have been proved to be the definitive predictive model of accuracy. We suggest a new predictive model, and investigated which model has the highest predictive accuracy for the short-term outcome in patients who underwent living donor liver transplantation (LDLT) due to ALF. Read More

    Urgent Liver Transplantation for Dietary Supplements: An Under-Recognized Problem.
    Transplant Proc 2017 Mar;49(2):322-325
    Division of Abdominal Organ Transplantation/Hepatobiliary Surgery, Oregon Health and Sciences University, Portland VA Medical Center, Portland, Oregon.
    Background: The recent outbreak of acute liver failure caused by herbal/dietary supplements (HDS) in Hawaii prompted evaluation of those patients who underwent emergency liver transplantation (LT) for HDS in the United States.

    Methods: We queried the Scientific Registry of Transplant Recipients (2003-2015) to identify patients who underwent urgent LT for acute hepatic necrosis (AHN) and identified those with HDS use. This group of patients was then characterized. Read More

    Regenerative medicine using dental pulp stem cells for liver diseases.
    World J Gastrointest Pharmacol Ther 2017 Feb;8(1):1-6
    Shogo Ohkoshi, Hajime Hara, Haruka Hirono, Kazuhiko Watanabe, Katsuhiko Hasegawa, Department of Internal Medicine, School of Life Dentistry at Niigata, Nippon Dental University, Chuo-ku 951-8580, Japan.
    Acute liver failure is a refractory disease and its prognosis, if not treated using liver transplantation, is extremely poor. It is a good candidate for regenerative medicine, where stem cell-based therapies play a central role. Mesenchymal stem cells (MSCs) are known to differentiate into multiple cell lineages including hepatocytes. Read More

    Hepatic Kaposi sarcoma: A case report and review of the literature.
    World J Hepatol 2017 Feb;9(4):171-179
    Brett Van Leer-Greenberg, Abhisake Kole, Saurabh Chawla, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States.
    Kaposi sarcoma (KS) is an aggressive cancer caused by human herpesvirus-8, primarily seen in immunocompromised patients. As opposed to the well-described cutaneous manifestations and pulmonary complications of KS, hepatic KS is rarely reported before death as most patients with hepatic KS do not manifest symptoms or evidence of liver injury. In patients with acquired immune deficiency syndrome, hepatic involvement of KS is present in 12%-24% of the population on incidental imaging and in approximately 35% of patients with cutaneous KS if an autopsy was completed after their death. Read More

    Liver transplantation from a deceased donor with β-thalassemia intermedia is not contraindicated: A case report.
    Pediatr Transplant 2017 Feb 17. Epub 2017 Feb 17.
    Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
    The use of extended criteria donors who might have previously been deemed unsuitable is an option to increase the organ supply for transplantation. This report presents a pediatric case of a successful liver transplantation from a donor with β-thalassemia intermedia. A patient, 6-year-old female, with a diagnosis of cryptogenic liver cirrhosis underwent deceased donor liver transplantation from a thalassemic donor. Read More

    Renal replacement therapy in critically ill liver cirrhotic patients - Outcome and Clinical Implications.
    Liver Int 2017 Feb 16. Epub 2017 Feb 16.
    Division of Gastroenterology and Hepatology, Intensive Care Unit 13h1, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna.
    Background & Aims: Current guidelines discourage renal replacement therapy (RRT) in critically ill cirrhotics in the lack of liver transplant (LT) options. This study aimed to identify patients who benefit from RRT in the short and long-term.

    Methods: Critically ill cirrhotics were included over a time period of 6 years (y) and followed for at least 1y. Read More

    [Acute-on-chronic liver failure: a diagnostic and therapeutic challenge for intensive care].
    Med Klin Intensivmed Notfmed 2017 Feb 16. Epub 2017 Feb 16.
    Klinik für Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Deutschland.
    Acute-on-chronic liver failure (ACLF) is an emerging clinical syndrome in patients with underlying liver disease that is usually triggered by one or multiple insults and characterized by progressive hepatic and nonhepatic organ failure, a significant risk of infections, and high short-term mortality rates. Despite our incomplete understanding of the underlying pathophysiology, ACLF requires timely diagnostic and therapeutic measures aiming at the identification and elimination of causative factors as well as the prevention of complications to improve the prognosis of affected patients. Read More

    Deoxyribonuclease partially ameliorates thioacetamide-induced hepatorenal injury.
    Am J Physiol Gastrointest Liver Physiol 2017 Feb 16:ajpgi.00446.2016. Epub 2017 Feb 16.
    Comenius University
    Several recent studies have shown that liver injury is associated with the release of DNA from hepatocytes. This DNA stimulates innate immunity and induces sterile inflammation exacerbating the liver damage. Similar mechanisms have been described for acute renal injury. Read More

    Sestrin2 protects against Acetaminophen-induced liver injury.
    Chem Biol Interact 2017 Feb 13. Epub 2017 Feb 13.
    College of Pharmacy, Chosun University, Gwangju 61452, Republic of Korea. Electronic address:
    Acetaminophen (APAP) overdose accounts for half of the cases of acute liver failure worldwide. We previously reported that that Sestrin2 (Sesn2) protects against d-galactosamine/lipopolysaccharide-induced acute fulminant liver failure. In this study, we demonstrated that Sesn2 protects APAP-induced liver injury in mice, using a recombinant adenovirus encoding Sesn2 (Ad-Sesn2). Read More

    First clinical experience in 14 patients treated with ADVOS: a study on feasibility, safety and efficacy of a new type of albumin dialysis.
    BMC Gastroenterol 2017 Feb 16;17(1):32. Epub 2017 Feb 16.
    Jamaica Hospital Medical Center, 8900 Van Wyck Expy, Jamaica, NY, 11418, USA.
    Background: Liver failure (LF) is associated with prolonged hospital stay, increased cost and substantial mortality. Due to the limited number of donor organs, extracorporeal liver support is suggested as an appealing concept to "bridge to transplant" or to avoid transplant in case of recovery. ADVanced Organ Support (ADVOS) is a new type of albumin dialysis, that provides rapid regeneration of toxin-binding albumin by two purification circuits altering the binding capacities of albumin by biochemical (changing of pH) and physical (changing of temperature) modulation of the dialysate. Read More

    Protein Requirements for Critically Ill Patients With Renal and Liver Failure.
    Nutr Clin Pract 2017 Feb 1:884533616687501. Epub 2017 Feb 1.
    5 Department of Medicine, Mayo Clinic, Rochester, Minnesota.
    Diseases leading to critical illness induce proteolysis resulting in muscle wasting and negative nitrogen balance. Muscle wasting has been associated with poor intensive care unit (ICU)-related outcomes, including an increased risk for mortality. Acute kidney injury (AKI) represents a common organ dysfunction associated with ICU-related disorders, such as sepsis, trauma, and respiratory failure. Read More

    Acute Liver Failure/Injury Related to Drug Reaction With Eosinophilia and Systemic Symptoms: Outcomes and Prognostic Factors.
    Transplantation 2017 Feb 15. Epub 2017 Feb 15.
    1APHP Hôpital Paul-Brousse, Centre Hépato-Biliaire Villejuif, F-94800, France 2INSERM, Unité 1193, Univ Paris-Saclay, Villejuif, F-94800, France 3Univ Paris-Sud, UMR-S 1193, Université Paris-Saclay, Villejuif, F-94800, France 4DHU Hepatinov, Villejuif, F-94800, France 5APHP Hôpital Bicêtre, Department of anatomo-pathology, Le Kremlin-Bicêtre, France 6Hôpital de Hautepierre, Department of liver surgery and transplantation, Strasbourg, 67200, France 7APHP Hôpital Beaujon, Department of hepatology, liver intensive care, Clichy, 92110, France 8APHP Hôpital Henri Mondor, Department of dermatology, Créteil, 94000, France 9Hôpital André Mignot, Department of Dermatology, Le Chesnay, 78157, France 10APHP Hôpital Henri Mondor, Department of liver surgery, Créteil, 94000, France. 11APHP Hôpital Henri Mondor, Intensive Care Unit, Créteil, 94000, France.
    Background: Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) is a rare severe adverse drug induced reaction with multiorgan involvement. The outcome and prediction of those patients who develop severe acute liver injury (sALI) or acute liver failure (ALF) remain little known.

    Methods: A multicenter retrospective study of patients admitted with a diagnosis of DRESS-related sALI or ALF. Read More

    Virological and serological features of acute hepatitis B in adults.
    Medicine (Baltimore) 2017 Feb;96(7):e6088
    International Medical Department, Beijing You'an Hospital, Capital Medical University, Beijing, China.
    Various viral kinetics among patients with acute hepatitis B (AHB) have been observed in clinical practice. This study investigated the virological, biochemical, and serological characteristics of AHB in adults.A total of 192 adult patients with AHB were recruited between December 2010 and January 2014. Read More

    Autoimmune hepatitis in patients with human immunodeficiency virus (HIV): Case reports of a rare, but important diagnosis with therapeutic implications.
    Medicine (Baltimore) 2017 Feb;96(7):e6011
    aDivision of Gastroenterology and Hepatology, Department of Medicine bDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL.
    Rationale: Chronic liver disease is a major cause of morbidity and mortality in patients with HIV. However, autoimmune hepatitis (AIH) in patients with HIV has rarely been reported. Our aim was to evaluate a cohort of patients with HIV and AIH and identify clinical presentations and outcomes. Read More

    Effect of N-Acetylcysteine on Mortality and Liver Transplantation Rate in Non-Acetaminophen-Induced Acute Liver Failure: A Multicenter Study.
    Clin Drug Investig 2017 Feb 15. Epub 2017 Feb 15.
    Internal Medicine and Hepatology Department, National Liver Institute, Menoufya University, Al Minufya, Shibin El Kom, Menoufya Governorate, Egypt.
    Introduction And Aim: Previous studies and systematic reviews have not provided conclusive evidence on the effect of N-acetylcysteine (NAC) in non-acetaminophen-induced acute liver failure (NAI-ALF). We aimed to study the value of intravenous NAC in reducing liver transplantation and mortality in NAI-ALF.

    Patients And Methods: In a prospective, multicenter, observational study, acute liver failure patients without clinical or historical evidence of acetaminophen overdose were enrolled. Read More

    Arq Gastroenterol 2017 Feb 13. Epub 2017 Feb 13.
    Programa de Pós-Graduação BioSaúde, Universidade Luterana do Brasil, Canoas, RS, Brazil.
    Background: Severe Acute Liver Failure (ALF) is a life-threatening clinical syndrome characterized by hepatocyte necrosis, loss of hepatic architecture, and impairment of liver functions. One of the main causes of ALF is hepatotoxicity from chemical agents, which damage hepatocytes and result in increase of reactive oxygen species. The vitamin E isoform is the one with the strongest biological antioxidant activity. Read More

    Herbal Compound "Jiedu Huayu" Reduces Liver Injury in Rats via Regulation of IL-2, TLR4, and PCNA Expression Levels.
    Evid Based Complement Alternat Med 2017 19;2017:9819350. Epub 2017 Jan 19.
    Department of Liver Disease, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi 530023, China.
    Aim of the Study. To investigate the preventative effects of Jiedu Huayu (JDHY) on D-galactosamine (D-GalN) and lipopolysaccharide-induced acute liver failure (ALF) and to evaluate the possible mechanisms of action. Materials and Methods. Read More

    Development and validation of a prognostic model for acute-on-chronic hepatitis B liver failure.
    Eur J Gastroenterol Hepatol 2017 Feb 13. Epub 2017 Feb 13.
    aCenter of Integrative Medicine bStatistics Room, Beijing Ditan Hospital, Capital Medical University cDepartment of Gastroenterology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
    Aim: The CANONIC study proposed the Chronic Liver Failure Consortium acute-on-chronic liver failure (CLIF-C ACLF) prognostic model at the European Association for the Study of the Liver-CLIF diagnosis. This study aimed to develop and validate a prognostic model for predicting the short-term mortality of hepatitis B virus (HBV) ACLF as defined by the Asia-Pacific Association for the Study of the Liver.

    Patients And Methods: A retrospective cohort of 381 HBV ACLF patients and a prospective cohort of 192 patients were included in this study. Read More

    Galectin-9: Diverse Roles in Hepatic Immune Homeostasis and Inflammation.
    Hepatology 2017 Feb 13. Epub 2017 Feb 13.
    Glycan-binding proteins which include galectins are involved at all stages of immunity and inflammation, ranging from initiation through resolution. Galectin-9 (Gal-9) is highly expressed in the liver and has a wide variety of biological functions in innate and adaptive immunity that are instrumental in the maintenance of hepatic homeostasis. In the setting of viral hepatitis, increased expression of Gal-9 drives the expansion of regulatory T cells and contraction of effector T cells, thereby favoring viral persistence. Read More

    High-Speed Quantitative UPLC-MS Analysis of Multiple Amines in Human Plasma and Serum via Precolumn Derivatization with 6-Aminoquinolyl-N-hydroxysuccinimidyl Carbamate: Application to Acetaminophen-Induced Liver Failure.
    Anal Chem 2017 Feb 7;89(4):2478-2487. Epub 2017 Feb 7.
    Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London , South Kensington, London SW7 2AZ, United Kingdom.
    A targeted reversed-phase gradient UPLC-MS/MS assay has been developed for the quantification /monitoring of 66 amino acids and amino-containing compounds in human plasma and serum using precolumn derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AccQTag Ultra). Derivatization of the target amines required minimal sample preparation and resulted in analytes with excellent chromatographic and mass spectrometric detection properties. The resulting method, which requires only 10 μL of sample, provides the reproducible and robust separation of 66 analytes in 7. Read More

    Deregulation of Regulatory T Cells in Acute-on-Chronic Liver Failure: A Rat Model.
    Mediators Inflamm 2017 15;2017:1390458. Epub 2017 Jan 15.
    Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Key Laboratory of Hepatology, Hepatology Institute of Wenzhou Medical University, Wenzhou, Zhejiang, China.
    Aims. Acute-on-chronic liver failure (ACLF) and acute liver failure (ALF) are similar in many respects during their acute exacerbation; however, ACLF generally has a poorer prognosis. We aimed to investigate the role and dynamic changes of regulatory T cell (Treg) and T helper 17 (Th17) cell proportions during ACLF progress. Read More

    Increased risk of dementia in patients hospitalized with acute kidney injury: A nationwide population-based cohort study.
    PLoS One 2017 13;12(2):e0171671. Epub 2017 Feb 13.
    Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
    Purpose: To determine whether acute kidney injury (AKI) is a risk factor for dementia.

    Methods: This nationwide population-based cohort study was based on data from the Taiwan National Health Insurance Research Database for 2000-2011. The incidence and relative risk of dementia were assessed in 207788 patients hospitalized for AKI. Read More

    Klebsiella Pneumoniae Liver Abscess: a Case Report and Review of Literature.
    Cureus 2017 Jan 10;9(1):e970. Epub 2017 Jan 10.
    Medicine, University of Tennessee Health Science Center.
    Klebsiella pneumoniae (K.pneumoniae) is a known cause of pyogenic liver abscess (PLA) in the absence of hepatobiliary disease. In settings of hepatic infection, it has also been known to cause disseminated infections including meningitis and endopthalmitis. Read More

    Prevention of acute kidney injury in Intensive Care Units.
    Med Intensiva 2017 Feb 9. Epub 2017 Feb 9.
    Intensive Care Medicine, Hospital General Universitario de Castellón, Spain.
    Acute kidney injury (AKI) is a growing concern in Intensive Care Units. The advanced age of our patients, with the increase in associated morbidity and the complexity of the treatments provided favor the development of AKI. Since no effective treatment for AKI is available, all efforts are aimed at prevention and early detection of the disorder in order to establish secondary preventive measures to impede AKI progression. Read More

    Features of Patients With Severe Hepatitis Due to Mushroom Poisoning and Factors Associated with Outcome.
    Clin Gastroenterol Hepatol 2017 Feb 9. Epub 2017 Feb 9.
    Department of Transplantation California Pacific Medical Center, San Francisco, CA.
    Background & Aims: Acute liver failure following ingestion of toxic mushrooms is a significant medical problem. Most exposures to toxic mushrooms produce no symptoms or only mild gastroenteritis, but some lead to severe hepatic necrosis and fulminant hepatic failure requiring liver transplantation. We aimed to assess mortality from mushroom poisoning and identify variables associated with survival and liver transplantation. Read More

    Hypermethylation of the galectin-3 promoter is associated with poor prognosis of acute-on-chronic hepatitis B liver failure.
    Dig Liver Dis 2017 Jan 22. Epub 2017 Jan 22.
    Department of Hepatology, Qilu Hospital of Shandong University, Jinan, China; Institute of Hepatology, Shandong University, Jinan, China. Electronic address:
    Background And Aims: The possible role of galectin-3 in acute-on-chronic hepatitis B liver failure (ACHBLF) remains unknown. This study aimed to determine the methylation status of the galectin-3 promoter in patients with ACHBLF and analyze its prognostic value.

    Methods: The methylation status of the galectin-3 promoter in patients with ACHBLF, chronic hepatitis B (CHB) and healthy controls (HCs) was determined by methylation-specific polymerase chain reaction (MSP). Read More

    Unexpected extrapyramidal symptoms and pulmonary aspergillosis in exertional heatstroke with fulminant liver failure: a case report.
    J Med Case Rep 2017 Feb 10;11(1):37. Epub 2017 Feb 10.
    Critical Care Medicine, Chinese PLA General Hospital, 28th Fuxing Road, Haidian District, Beijing, 100853, China.
    Background: Exertional heatstroke is a life-threatening condition with high mortality because of the rapid progress of multiple organ dysfunction syndrome even if aggressive treatments are initiated rapidly. Mild to moderate hepatic injury is common in exertional heatstroke, while fulminant liver failure is rare. Extrapyramidal symptoms and pulmonary aspergillosis secondary to liver failure induced by exertional heatstroke have never been reported in prior cases. Read More

    Mortality after portal vein embolization: Two case reports.
    Medicine (Baltimore) 2017 Feb;96(6):e5446
    Center for Liver Cancer, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea.
    Portal vein embolization (PVE) is increasingly performed worldwide to reduce the possibility of liver failure after extended hepatectomy, by inducing future liver remnant (FLR) hypertrophy and atrophy of the liver planned for resection. The procedure is known to be very safe and to have few procedure-related complications.In this study, we described 2 elderly patients with Bismuth-Corlette type IV Klatskin tumor who underwent right trisectional PVE involving the embolization of the right portal vein, the left medial sectional portal branch, and caudate portal vein. Read More

    Acute Respiratory Distress Syndrome in Pregnant Women.
    Obstet Gynecol 2017 Mar;129(3):530-535
    Division of Critical Care Medicine, Department of Medicine, Vancouver General Hospital, and the Departments of Anesthesia, Pharmacology and Therapeutics and Orthopaedic Surgery, the Centre for Heart Lung Innovation, and the Division of Critical Care Medicine, St Paul's Hospital, University of British Columbia, Vancouver, and the Department of Critical Care Medicine, Surrey Memorial Hospital, Surrey, British Columbia, Canada; and Harvard T. H. Chan School of Public Health, Harvard University, and Beth Israel Deaconess Medical Center, Boston, Massachusetts.
    Objective: To estimate the rate of acute respiratory distress syndrome (ARDS) in pregnant patients as well as to investigate clinical conditions associated with mortality.

    Methods: We used the Nationwide Inpatient Sample from 2006 to 2012 to identify a cohort of pregnant patients who underwent mechanical ventilation for ARDS. A multivariate model predicting in-hospital mortality was created. Read More

    Hepato and neuro-protective influences of biopropolis on thioacetamide-induced acute hepatic encephalopathy in rats.
    Can J Physiol Pharmacol 2016 Dec 9. Epub 2016 Dec 9.
    Faculty of Veterinary Medicine, Cairo University, Biochemistry Department, Giza, Egypt.
    Hepatic encephalopathy (HE) is a neuropsychiatric syndrome ultimately occurs as a complication of acute or chronic liver failure; accompanied by hyperammonemia. This study aimed to evaluate the potential of biopropolis as a hepato and neuroprotective agent using thioacetamide (TAA)-induced acute HE in rats as a model. Sixty Wistar rats were divided into five groups: Group 1 (normal control) received only saline and paraffin oil. Read More

    Suspected atypical haemolytic uraemic syndrome in two post-partum patients with foetal-death in utero responding to eculizumab.
    Nephrology (Carlton) 2017 Feb;22 Suppl 1:18-22
    Department of Nephrology, Austin Hospital, Victoria, Australia.
    Background: Atypical haemolytic uraemic syndrome (aHUS) is a rare condition with the triad of microangiopathic haemolytic anaemia, thrombocytopenia and acute kidney injury. Other conditions that present in a similar manner peri-partum include thrombotic thrombocytopaenic purpura, and pregnancy associated conditions including HELLP syndrome (haemolysis, elevated liver enzymes and low platelets), severe pre-eclampsia and less commonly acute fatty liver of pregnancy.

    Case Reports: We describe two cases of suspected aHUS, who presented post-partum with foetal death-in-utero at 33 and 37 weeks respectively. Read More

    Immunomodulatory Effects of Adipose Tissue-Derived Stem Cells on Concanavalin A-Induced Acute Liver Injury in Mice.
    Cell Med 2017 Jan 6;9(1-2):21-33. Epub 2016 Oct 6.
    Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine , Higashi-ku, Nagoya , Japan.
    Cell therapy with adipose tissue-derived stem cells (ASCs) is expected to be a candidate for the treatment of fulminant hepatic failure (FHF), which is caused by excessive immune responses. In order to evaluate the therapeutic effects of ASCs on FHF, the in vitro and in vivo immunomodulatory effects of ASCs were examined in detail in the mouse model. The in vitro effects of ASCs were examined by assessing their influence on the proliferation of lymphomononuclear cells (LMCs) stimulated with three kinds of mitogens: phorbol 12-myristate 13-acetate (PMA) plus ionomycin, concanavalin A (ConA), and lipopolysaccharide (LPS). Read More

    A clinical score to predict mortality in septic acute kidney injury patients requiring continuous renal replacement therapy: the HELENICC score.
    BMC Anesthesiol 2017 Feb 7;17(1):21. Epub 2017 Feb 7.
    Hospital Português, Salvador, Brazil.
    Background: This study aimed to identify predictors of early (7-day) mortality in patients with septic acute kidney injury (AKI) who required continuous renal replacement therapy (CRRT).

    Methods: Prospective cohort of 186 septic AKI patients undergoing CRRT at a tertiary hospital, from October 2005 to November 2010.

    Results: After multivariate adjustment, five variables were associated to early mortality: norepinephrine utilization, liver failure, medical condition, lactate level, and pre-dialysis creatinine level. Read More

    Recent advances in liver transplantation for metabolic disease.
    J Inherit Metab Dis 2017 Feb 6. Epub 2017 Feb 6.
    Division of Gastroenterology/Hepatology/Nutrition Children's Hospital of Pittsburgh of UPMC, Pittsburgh Liver Research Centre, University of Pitttsburgh, 4401 Penn Avenue, Pittsburgh, PA, 15224, USA.
    The indications and outcomes of liver transplantation for metabolic disease have been reviewed recently and this short review concentrates on recent developments and advances. Recently recognized metabolic causes of acute liver failure are reviewed and their implications for transplantation discussed. Newly described indications for liver transplantation in systemic metabolic diseases are described and an update is given on the role of auxiliary and domino liver transplantation. Read More

    Astaxanthin pretreatment attenuates acetaminophen-induced liver injury in mice.
    Int Immunopharmacol 2017 Jan 31;45:26-33. Epub 2017 Jan 31.
    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, PR China. Electronic address:
    Background: Acetaminophen (APAP) is a conventional drug widely used in the clinic because of its antipyretic-analgesic effects. However, accidental or intentional APAP overdoses induce liver injury and even acute liver failure (ALF). Astaxanthin (ASX) is the strongest antioxidant in nature that shows preventive and therapeutic properties, such as ocular protection, anti-tumor, anti-diabetes, anti-inflammatory, and immunomodulatory effects. Read More

    Model for End-stage Liver Disease excluding INR (MELD-XI) score in critically ill patients: Easily available and of prognostic relevance.
    PLoS One 2017 2;12(2):e0170987. Epub 2017 Feb 2.
    Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Duesseldorf, Germany.
    Purpose: MELD-XI, an adapted version of Model for End-stage Liver Disease (MELD) score excluding INR, was reported to predict outcomes e.g. in patients with acute heart failure. Read More

    Gamma-glutamyl transferase and cardiovascular disease.
    Ann Transl Med 2016 Dec;4(24):481
    Department of Adult Cardiology, Deutsches Herzzentrum München, Technische Universität, Munich, Germany;; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
    Gamma-glutamyl transferase (GGT) is an enzyme located on the external surface of cellular membranes. GGT contributes in maintaining the physiological concentrations of cytoplasmic glutathione and cellular defense against oxidative stress via cleavage of extracellular glutathione and increased availability of amino acids for its intracellular synthesis. Increased GGT activity is a marker of antioxidant inadequacy and increased oxidative stress. Read More

    Hepatitis C and kidney disease: A narrative review.
    J Adv Res 2017 Mar 26;8(2):113-130. Epub 2016 Jul 26.
    The Cairo Kidney Center, Cairo, Egypt.
    Hepatitis-C (HCV) infection can induce kidney injury, mostly due to formation of immune-complexes and cryoglobulins, and possibly to a direct cytopathic effect. It may cause acute kidney injury (AKI) as a part of systemic vasculitis, and augments the risk of AKI due to other etiologies. It is responsible for mesangiocapillary or membranous glomerulonephritis, and accelerates the progression of chronic kidney disease due to other causes. Read More

    Pediatric Liver Transplantation: Our Experiences.
    Eurasian J Med 2016 Oct;48(3):209-212
    Department of Pediatric Gastroenterology, Akdeniz University School of Medicine, Antalya, Turkey.
    Objective: The aim of our study was to evaluate our liver transplant pediatric patients and to report our experience in the complications and the long-term follow-up results.

    Materials And Methods: Patients between the ages of 0 and 18 years, who had liver transplantation in the organ transplantation center of our university hospital between 1997 and 2016, were included in the study. The age, sex, indications for the liver transplantation, complications after the transplantation, and long-term follow-up findings were retrospectively evaluated. Read More

    En-Bloc Transplant of the Liver, Kidney and Pancreas: Experience from a Latin American Transplant Center.
    Am J Case Rep 2017 Feb 2;18:114-118. Epub 2017 Feb 2.
    Abdominal Transplantation Surgery, Transplantation Unit, Centre for Clinical Research, Fundación Valle de Lili, Centre for Research on Advanced Surgery and Transplants (CICAT), Universidad Icesi, Cali, Valle del Cauca, Colombia.
    BACKGROUND En-bloc transplantation is a surgical procedure in which multiple organs are transplanted simultaneously. It has some similarities with multi-organ transplantation but offers certain advantages. This report highlights the experience of our interdisciplinary group regarding the treatment and follow-up of patients who received en-bloc transplantation, with the aim of encouraging the development of this surgical technique. Read More

    1 OF 325