18,362 results match your criteria Acute Liver Failure


Hepatic differentiation of human pluripotent stem cells by developmental stage-related metabolomics products.

Differentiation 2019 Jan 28;105:54-70. Epub 2019 Jan 28.

Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Diabetes Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Irwin S. and Sylvia Chanin Institute for Cancer Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

Endogenous cell signals regulate tissue homeostasis and are significant for directing the fate of stem cells. During liver development, cytokines released from various cell types are critical for stem/progenitor cell differentiation and lineage expansions. To determine mechanisms in these stage-specific lineage interactions, we modeled potential effects of soluble signals derived from immortalized human fetal liver parenchymal cells on stem cells, including embryonic and induced pluripotent stem cells. Read More

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http://dx.doi.org/10.1016/j.diff.2019.01.005DOI Listing
January 2019

Giant Gastroschisis with Complete Liver Herniation: A Case Report of Two Patients.

Case Rep Surg 2019 15;2019:4136214. Epub 2019 Jan 15.

Department of General Surgery, Boston Children's Hospital, 300 Longwood Ave, Fegan 3, Boston MA 20115, USA.

Introduction: There are no reported survivors of gastroschisis with complete liver herniation. We describe a case report of two patients, one of whom survived.

Case #1: The patient was born with gastroschisis and herniation of the entire liver. Read More

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http://dx.doi.org/10.1155/2019/4136214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350565PMC
January 2019

Bile Acids in Hepatic Encephalopathy.

Authors:
Sharon DeMorrow

J Clin Exp Hepatol 2019 Jan-Feb;9(1):117-124. Epub 2018 May 4.

Department of Medical Physiology, Texas A&M College of Medicine, Temple, TX 76504, USA.

Hepatic encephalopathy describes the array of neurological complications that arise due to liver insufficiency and/or portal-systemic shunt. The pathogenesis of hepatic encephalopathy shares a longstanding association with hyperammonemia and inflammation. Recently, aberrant bile acid signaling has been implicated in the development of key features of hepatic encephalopathy due to acute liver failure including neuronal dysfunction, neuroinflammation and blood-brain barrier permeability. Read More

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http://dx.doi.org/10.1016/j.jceh.2018.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363980PMC

Quantitative real-time PCR for differential diagnostics of parvovirus B19 infection in acute liver failure patients.

Expert Rev Mol Diagn 2019 Feb 18. Epub 2019 Feb 18.

a Laboratório de Desenvolvimento Tecnológico em Virologia, Instituto Oswaldo cruz, Fundação Oswaldo Cruz , Rio de Janeiro , RJ , Brasil.

Background: Human Parvovirus B19 (B19V) is a common pathogen worldwide. After primary infection, B19V-DNA may permanently persist in non-erythroid tissues, including the liver of patients with acute liver failure (ALF).

Objective: To validate a real-time PCR (qPCR) for the quantification of B19V-DNA, in order to establish a differential diagnosis for B19V infection in ALF patients. Read More

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http://dx.doi.org/10.1080/14737159.2019.1582333DOI Listing
February 2019

Obeticholic acid differentially regulates hepatic injury and inflammation at different stages of D-galactosamine/lipopolysaccharide-evoked acute liver failure.

Eur J Pharmacol 2019 Feb 14. Epub 2019 Feb 14.

Department of Toxicology, Anhui Medical University, Hefei, 230032, China. Electronic address:

The farnesoid X receptor (FXR) is a ligand-activated transcription factor that regulates genes involved in bile acid metabolism. Accumulating data demonstrate that FXR has an anti-inflammatory activity. The present study aimed to investigate the effect of obeticholic acid (OCA), a novel synthetic FXR agonist, on D-galactosamine (GalN)/lipopolysaccharide (LPS)-evoked acute liver injury. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.02.011DOI Listing
February 2019

The impact and evolution of acute-on-chronic liver failure in decompensated cirrhosis: A Portuguese single-center study.

Gastroenterol Hepatol 2019 Feb 13. Epub 2019 Feb 13.

Gastroenterology Department, Hospital Professor Doutor Fernando Fonseca, Amadora, Portugal.

Introduction: Acute-on-chronic liver failure (ACLF) is a dynamic syndrome that should be assessed repeatedly. An algorithm for risk stratification in decompensated cirrhosis was recently proposed by the EASL-CLIF (European Association for the Study of the Liver-Chronic Liver Failure) Consortium.

Aim: To validate the EASL-CLIF Consortium scores in patients with and without ACLF. Read More

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http://dx.doi.org/10.1016/j.gastrohep.2018.11.007DOI Listing
February 2019

Diagnosis, Development, and Treatment of Portal Vein Thrombosis in Patients With and Without Cirrhosis.

Gastroenterology 2019 Feb 13. Epub 2019 Feb 13.

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, and Fondazione Luigi Villa, Milano, Italy.

Portal vein thrombosis unrelated to solid malignancy is common in patients with cirrhosis but less frequently observed in patients without cirrhosis. Prompt diagnosis and management of acute symptomatic portal vein thrombosis are essential. Failure to detect and treat thromboses can result in mesenteric ischemia, chronic cavernous transformation, and complications of portal hypertension. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.265DOI Listing
February 2019

N-myc and STAT interactor correlates with severity and prognosis in acute-on-chronic liver failure of hepatitis B virus.

J Gastroenterol Hepatol 2019 Feb 16. Epub 2019 Feb 16.

Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China.

Background And Aim: Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is characterized by acute deterioration of chronic liver disease with excessive inflammation. N-myc and STAT interactor (NMI), an inflammation-mediated protein, involves in various inflammatory related diseases, but the role of NMI in development and prognosis in HBV-ACLF remains to be elucidated.

Methods: Serum NMI from healthy controls (HCs, n=20), chronic hepatitis B (CHB, n=50) patients and HBV-ACLF patients (n=50) were determined using ELISA. Read More

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http://dx.doi.org/10.1111/jgh.14634DOI Listing
February 2019

Suramin protects hepatocytes from LPS-induced apoptosis by regulating mitochondrial stress and inactivating the JNK-Mst1 signaling pathway.

J Physiol Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Intensive Care Medicine, Shanghai Sixth People's Hospital affiliated to Shanghai University of Medicine and Health Sciences, No. 222 Huanhuxisan Road, Pudong, 201306, Shanghai, China.

An uncontrolled inflammatory response has been implicated in the progression of acute liver failure through poorly understood mechanisms. The aim of our study was to investigate whether suramin attenuates inflammation-mediated hepatocyte apoptosis by modulating mitochondrial homeostasis. Primary hepatocytes were isolated from mice and treated with LPS in vitro in the presence or absence of suramin. Read More

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http://dx.doi.org/10.1007/s12576-019-00666-9DOI Listing
February 2019

Corticosteroid Therapy for Indeterminate Pediatric Acute Liver Failure and Aplastic Anemia with Acute Hepatitis.

J Pediatr 2019 Feb 12. Epub 2019 Feb 12.

Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL.

Objective: To examine the characteristics and outcomes of a multicenter patient cohort with indeterminate pediatric acute liver failure (IND-PALF) and with aplastic anemia with acute hepatitis treated with corticosteroids.

Study Design: Retrospective study of patients age 1-17 years with IND-PALF and aplastic anemia with acute hepatitis who presented between 2009 and 2018 to 1 of 4 institutions and were treated with corticosteroids for presumed immune dysregulation.

Results: Of 28 patients with IND-PALF (median of 4. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.042DOI Listing
February 2019

Drug-induced idiosyncratic acute liver failure: A challenging and distressing scenario.

Curr Drug Saf 2019 Feb 14. Epub 2019 Feb 14.

Latin American Liver Research Educational and Awareness Network (LALREAN). Argentina.

Idiosyncratic drug induced liver injury (DILI) is a rare adverse event to drugs that occasionally leads to severe liver damage, being one of the leading causes of acute liver failure (ALF) in developed countries. DILI is largely a diagnosis of exclusion. Thus, careful history of drug taking and ruling out other competing etiologies is mandatory given that DILI can present with an extremely variable phenotype. Read More

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http://dx.doi.org/10.2174/1574886314666190215115434DOI Listing
February 2019

The yield and safety of screening colonoscopy in patients evaluated for liver transplantation.

Hepatology 2019 Feb 14. Epub 2019 Feb 14.

Department of Gastroenterology and Hepatology, Erasmus MC University Hospital, Rotterdam, Netherlands.

Colorectal cancer screening with colonoscopy is commonly used in candidate patients for liver transplantation. We initiated this study to define the risk-benefit ratio of performing screening colonoscopy in this population. A retrospective observational study of all consecutive patients undergoing colonoscopy during pre-liver transplantation screening between 2004-2017 was conducted. Read More

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http://dx.doi.org/10.1002/hep.30562DOI Listing
February 2019

Neurological Recovery After Recovery From Acute Liver Failure: Is it Complete?

J Clin Exp Hepatol 2019 Jan-Feb;9(1):99-108. Epub 2018 Jun 22.

Indraprastha Apollo Hospital, New Delhi, India.

Neurologic dysfunction characterised by Hepatic Encephalopathy (HE) and cerebral oedema are the most dramatic presentations of Acute Liver Failure (ALF) and signify poor outcome. Improved critical care and wider availability of emergency Liver Transplantation (LT) has improved survivability in ALF. In most cases absence of clinically overt encephalopathy after spontaneous recovery from ALF or after LT is thought to indicate complete neurologic recovery. Read More

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http://dx.doi.org/10.1016/j.jceh.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363962PMC

Wilson's Disease: Clinical Practice Guidelines of the Indian National Association for Study of the Liver, the Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition, and the Movement Disorders Society of India.

J Clin Exp Hepatol 2019 Jan-Feb;9(1):74-98. Epub 2018 Sep 3.

Department of Pediatrics and Pediatric Liver GI and Nutrition Center and Mowat Labs, King's College Hospital, London, UK.

Clinical practice guidelines for Wilson's disease (WD) have been published by the American Association for the Study of Liver Diseases and European Association for the Study of the Liver in 2008 and 2012, respectively. Their focus was on the hepatic aspects of the disease. Recently, a position paper on pediatric WD was published by the European Society of Pediatric Gastroenterology Hepatology and Nutrition. Read More

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http://dx.doi.org/10.1016/j.jceh.2018.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363961PMC
September 2018

Tocilizumab as first-line therapy for steroid-refractory acute graft-versus-host-disease: analysis of a single-center experience.

Leuk Lymphoma 2019 Feb 15:1-7. Epub 2019 Feb 15.

a Department of Pharmacy, The James Cancer Hospital , The Ohio State University Comprehensive Cancer Center , Columbus , Ohio , 43210 , USA.

Acute graft-versus-host-disease (aGVHD) is a complication after allogeneic stem cell transplant. After the failure of treatment with high dose corticosteroids, steroid-refractory aGVHD (SR aGVHD) is associated with high rates of mortality. Tocilizumab has evidence of activity in SR aGVHD. Read More

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http://dx.doi.org/10.1080/10428194.2019.1573996DOI Listing
February 2019

Therapeutic effect of double plasma molecular adsorption system and sequential half-dose plasma exchange in patients with HBV-related acute-on-chronic liver failure.

J Clin Apher 2019 Feb 13. Epub 2019 Feb 13.

Difficult & Complicated Liver Diseases and Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, Beijing, China.

Objective: The artificial liver support system (ALSS) is used frequently as a first-line treatment for hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF). This study aims to compare the therapeutic efficacy of double plasma molecular adsorption system (DPMAS) with sequential half-dose plasma exchange (PE) (DPMAS+PE) and full-dose PE in patients with HBV-ACLF.

Methods: A total of 131 hospitalized patients who were diagnosed with HBV-ACLF and underwent DPMAS+PE or PE were retrospectively analyzed. Read More

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http://dx.doi.org/10.1002/jca.21690DOI Listing
February 2019

Author's Response to Letter to the Editor: Noninvasive Intracranial Pressure Assessment in Acute Liver Failure.

Neurocrit Care 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurosurgery, University of Michigan, 3552 Taubman Health Care Center, SPC 5338, 1500 East Medical Center Drive, Ann Arbor, MI, 48109-5338, USA.

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http://dx.doi.org/10.1007/s12028-019-00681-zDOI Listing
February 2019
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Primary Hepatic Diffuse Large B-cell Lymphoma Mimicking Acute Fulminant Hepatitis: A Case Report and Review of the Literature.

Eur J Case Rep Intern Med 2018 26;5(6):000878. Epub 2018 Jun 26.

Department of Internal Medicine, Middle East Institute of Health, Faculty of Medical Science, Lebanese University, Hadath, Lebanon.

Primary hepatic lymphoma (PHL) is a rare variant of non-Hodgkin's lymphoma. Diffuse hepatic involvement is uncommon and therefore presentation as progressive hepatitis or acute fulminant hepatic failure is rare. Acute onset of signs and symptoms can mimic a variety of infectious and inflammatory disorders, thus delaying the diagnosis. Read More

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http://dx.doi.org/10.12890/2018_000878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346882PMC

Fatal Septic Shock Associated with Herpes Simplex Virus Hepatitis: A Case Report.

Eur J Case Rep Intern Med 2018 27;5(12):000982. Epub 2018 Dec 27.

Intensive Care Unit, Iris South Hospitals, Brussels, Belgium.

Herpes simplex viruses are endemic worldwide, with an estimated seroprevalence of approximately 70% in developed countries. However, it is less well known that they are one of the viral causes of fulminant hepatitis (<2%) and constitute <1% of all causes of acute liver failure. We describe the case of an 89-year-old man who developed sepsis caused by a urinary tract infection due to drug-sensitive . Read More

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http://dx.doi.org/10.12890/2018_000982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346974PMC
December 2018

Fetomaternal Outcome in Eclampsia in Relationship with Gravidity.

Mymensingh Med J 2019 Jan;28(1):44-48

Dr Anonya Talukder, Junior Consultant, Department of Obs. and Gynae, Mymensingh Medical College Hospital, Mymensingh, Bangladesh.

Eclampsia is a well-recognized major cause of maternal and perinatal morbidity and mortality. Patient's age, occupational status, socioeconomic status, educational status, regular ANC (antenatal care) and gravidity may affect the outcome of mother and foetus. The purpose of this study is to see the fetomaternal outcome in eclampsia in relationship with gravidity. Read More

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January 2019

Hypersensitivity reaction with multi-organ failure following re-exposure to rifampicin: case report and review of the literature including WHO spontaneous safety reports.

BMC Pharmacol Toxicol 2019 Feb 12;20(1). Epub 2019 Feb 12.

Department of Clinical Pharmacology & Toxicology, University Hospital Basel, Basel, Switzerland.

Background: True hypersensitivity reactions to rifampicin are relatively rare, nonetheless severe manifestations mostly involving a single organ have been documented. We report a case of acute multi-organ failure occurring after a medication error with re-exposure to rifampicin.

Case Presentation: A 68-year old patient developed acute hypersensitivity pneumonitis, acute renal failure, acute liver failure and haemolytic anemia within hours after a second re-exposure to Rifampicin for the treatment of a hip prosthesis infection with Staphylococcus epidermidis. Read More

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http://dx.doi.org/10.1186/s40360-019-0289-7DOI Listing
February 2019

Pharmacokinetics and Tissue Distribution of Aegeline after Oral Administration in Mice.

Planta Med 2019 Feb 12. Epub 2019 Feb 12.

National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, USA.

Aegeline is claimed to be a biologically active constituent of . Preclinical studies have reported possible therapeutic potential for aegeline against obesity and diabetes. In recent years, aegeline has been added to several weight loss products. Read More

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http://dx.doi.org/10.1055/a-0851-6879DOI Listing
February 2019
1 Read

Acetaminophen aggravates fat accumulation in NAFLD by inhibiting autophagy via the AMPK/mTOR pathway.

Eur J Pharmacol 2019 Feb 10;850:15-22. Epub 2019 Feb 10.

Institute for Liver Diseases of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei 230032, China; Key Laboratory of anti-inflammatory and Immune Medicine, Ministry of Education, Hefei 230032, China. Electronic address:

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease which affects millions of people worldwide. Acetaminophen (APAP) overdose is the leading cause of acute liver failure. In this study, APAP (50, 100, 200 mg/kg) were employed on mice fed with a high-fat diet, and APAP (2, 4, 8 mM) were cultured with L02 cells in the presence of alcohol and oleic acid. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.02.005DOI Listing
February 2019
1 Read

Long-term outcomes of patients with hepatitis B virus -related acute on chronic liver failure: an observational cohort study.

Liver Int 2019 Feb 12. Epub 2019 Feb 12.

Liver Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Background And Aims: The long-term outcomes of patients with hepatitis B virus -related acute-on-chronic liver failure (HBV-ACLF) remain unclear. The main aims of study was to compare the 5-year survival rate and incidence rate of hepatocellular carcinoma (HCC) between patients with HBV-ACLF and HBV-cirrhosis.

Methods: Clinical data of patients with ACLF, compensated cirrhosis and decompensated cirrhosis who survived more than 3 months after diagnosis were collected. Read More

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http://dx.doi.org/10.1111/liv.14072DOI Listing
February 2019
1 Read

[Acute decompensation (AD) of advanced chronic liver disease (ACLD) and hepatitis E virus (HEV) infection as the trigger].

Klin Mikrobiol Infekc Lek 2018 Sep;24(3):82-87

Division Hepatology, gastroenterology and liver transplantation of Department Internal medicine II, Faculty of Medicine, Slovak Medical University, FD Roosevelt Hospital, Banska Bystrica; Slovakia, e-mail:

Introduction: HEV infection is perceived as the cause of acute hepatitis in endemic areas. In addition, it may also manifest as a possible trigger of AD or acute-on-chronic liver failure (ACLF).

Objectives: To determine the prevalence of HEV infection as a trigger of AD/ACLF in patients admitted for decompensated ACLD (dACLD). Read More

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September 2018
2 Reads

Body Image in Liver transplant recipients.

Liver Transpl 2019 Feb 11. Epub 2019 Feb 11.

Department of Surgery and Pediatrics, Yale University School of Medicine.

Body Image (BI) concerns have been reported to play a significant role in the psychological adaptation post organ transplantation. There is a paucity of data about BI beliefs in liver transplant recipients. We report the results of a cross-sectional study of 177 liver transplant recipients in which we assessed BI, anxiety, depression and quality of life using validated instruments. Read More

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http://dx.doi.org/10.1002/lt.25432DOI Listing
February 2019
1 Read

Postoperative respiratory failure in liver transplantation: Risk factors and effect on prognosis.

PLoS One 2019 11;14(2):e0211678. Epub 2019 Feb 11.

Università Cattolica del Sacro Cuore, Rome, Italy.

Background: Postoperative respiratory failure (PRF, namely mechanical ventilation >48 hours) significantly affects morbidity and mortality in liver transplantation (LTx). Previous studies analyzed only one or two categories of PRF risk factors (preoperative, intraoperative or postoperative ones). The aims of this study were to identify PRF predictors, to assess the length of stay (LoS) in ICU and the 90-day survival according to the PRF in LTx patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211678PLOS
February 2019
1 Read

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis.

Liver Int 2019 Feb 9. Epub 2019 Feb 9.

Department of Medicine I, University of Bonn, Bonn, Germany.

Background: Remodeling of extracellular matrix (ECM) is crucial in progressive liver fibrosis. Collagen type III desposition has been shown in acute decompensation. ECM is compiled of deposition of various components. Read More

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http://dx.doi.org/10.1111/liv.14070DOI Listing
February 2019
2 Reads

A case of panitumumab containing chemotherapy causing interstitial lung disease: early recognition and treatment resulting in a good outcome.

BMJ Case Rep 2019 Feb 9;12(2). Epub 2019 Feb 9.

Department of Hematology/Oncology, Presence Saint Joseph Hospital Chicago, Chicago, Illinois, USA.

Panitumumab is a recombinant human IgG monoclonal antibody which is used for the treatment of patients with metastatic colorectal cancer (mCRC) with disease progression on or following FOLFIRI (fluoropyrimidine, oxaliplatin and irinotecan) containing chemotherapy regimen. We report a case of an 83-year-old Hispanic man, non-smoker, with KRAS/NRAS wild-type mCRC of the liver who was treated with 9 cycles of FOLFOX4 (fluorouracil, leucovorin and oxaliplatin) and cetuximab. Follow-up abdominal imaging showed progression of CRC, requiring initiation of panitumumab in addition to FOLFIRI. Read More

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http://dx.doi.org/10.1136/bcr-2018-227785DOI Listing
February 2019
1 Read

Acute liver failure increases kynurenic acid production in rat brain via changes in tryptophan metabolism in the periphery.

Neurosci Lett 2019 Feb 6;701:14-19. Epub 2019 Feb 6.

Department of Nutrition, School of Human Cultures, The University of Shiga Prefecture, 2500 Hassaka, Hikone, Shiga, 522-8533, Japan. Electronic address:

The tryptophan metabolite, kynurenic acid (KYNA), is a preferential antagonist of the α7 nicotinic acetylcholine receptor and N-methyl-d-aspartic acid receptor at endogenous brain concentrations. Recent studies have suggested that increased brain KYNA levels are involved in psychiatric disorders such as schizophrenia and depression. Most of the brain kynurenine (KYN), the KYNA precursor, comes from the periphery, and the liver has a central role in the peripheral tryptophan metabolism. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.004DOI Listing
February 2019
1 Read

Preliminary Experience With Hypothermic Oxygenated Machine Perfusion in an Italian Liver Transplant Center.

Transplant Proc 2019 Jan - Feb;51(1):111-116. Epub 2018 Jun 30.

Liver Transplant and General Surgery Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Machine perfusion is increasingly utilized in liver transplantation to face the detrimental consequences of the use of extended-criteria donors. Hypothermic oxygenated machine perfusion (HOPE) appears to be more protective relative to static cold storage. Conversely, normothermic machine perfusion (NMP) allows a better graft evaluation. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.070DOI Listing
June 2018
1 Read

Intracranial Pressure Evaluation in Acute Liver Failure.

Neurocrit Care 2019 Feb 7. Epub 2019 Feb 7.

Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Via S. Allende, 84081, Baronissi, Salerno, Italy.

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http://dx.doi.org/10.1007/s12028-019-00680-0DOI Listing
February 2019
1 Read

Acetaminophen is Undetectable in Plasma From More Than Half of Patients Believed to Have Acute Liver Failure Due to Overdose.

Clin Gastroenterol Hepatol 2019 Feb 4. Epub 2019 Feb 4.

Division of Digestive and Liver Diseases, The University of Texas Southwestern Medical Center, Dallas, TX, United States; Grant Support-This study was supported by a grant from the National Institute for Diabetes and Digestive and Kidney Diseases (U01-DK-58369 ) to the University of Texas Southwestern Medical Center at Dallas.

Background Aims: Evaluation of patients with acute liver injury (ALI) or acute liver failure (ALF) often includes measurement of plasma levels of acetaminophen, to determine exposure and/or toxicity. However, once liver injury has developed, acetaminophen might be undetectable in plasma. We investigated the association between level of acetaminophen measured and outcomes of patients designated as having ALF or ALI due to acetaminophen toxicity. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.01.040DOI Listing
February 2019
1 Read

Glycoproteomic Profiling Provides Candidate Myocardial Infarction Predictors of Later Progression to Heart Failure.

ACS Omega 2019 Jan 15;4(1):1272-1280. Epub 2019 Jan 15.

Mississippi Center for Heart Research, Department of Physiology and Biophysics, Department of Preventive Medicine and Cancer Institute, Jackson Heart Study, and Division of Cardiology, UMMC, Jackson, Mississippi 39216-4505, United States.

We hypothesized that identifying plasma glycoproteins that predict the development of heart failure following myocardial infarction (MI) could help to stratify subjects at risk. Plasma collected at visit 2 (2005-2008) from an MI subset of Jackson Heart Study participants underwent glycoproteomics and was grouped by the outcome: (1) heart failure hospitalization after visit 2 ( = 15) and (2) without hospitalization by 2012 ( = 45). Proteins were mapped for biological processes and functional pathways using Ingenuity Pathway Analysis and linked to clinical characteristics. Read More

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http://dx.doi.org/10.1021/acsomega.8b02207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356850PMC
January 2019
4 Reads

[Liver transplantation in a patient with human immunodeficiency virus (HIV). Case report].

Rev Med Chil 2018 Dec;146(10):1215-1219

Programa Trasplante Hepático, Hospital Clínico, Pontificia Universidad Católica de Chile, Santiago, Chile.

Abstrac: Before the advent of highly active antiretroviral therapy (HAART), patients infected with human immunodeficiency virus (HIV) were considered as having an absolute contraindication for liver transplantation (LT). Considering the increased life expectancy in HIV positive patients under HAART and the improvements in the management of graft recipients, these patients are now suitable for carrying out transplants in selected cases. We report a 26 years old HIV positive male who developed acute liver failure possibly caused by drug induced liver injury who underwent a successful liver transplantation. Read More

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http://dx.doi.org/10.4067/S0034-98872018001001215DOI Listing
December 2018
1 Read

The burden of illness of hepatorenal syndrome (HRS) in the United States: a retrospective analysis of electronic health records.

J Med Econ 2019 Feb 6. Epub 2019 Feb 6.

a Mallinckrodt Pharmaceuticals, Inc. , 1425 US Route 206 , Bedminster , NJ 07921 , USA.

Objectives: Hepatorenal Syndrome (HRS) is characterized by renal failure in patients with advanced chronic liver disease (CLD) and is the leading cause of hospitalizations in CLD. This study examines the clinical and economic burden, outcomes, and unmet need of HRS treatment in US hospitals.

Method: A retrospective cohort study was conducted based on a large electronic health records database (Cerner HealthFacts) with records for hospitalized HRS patients from January 2009 - June 2015. Read More

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http://dx.doi.org/10.1080/13696998.2019.1580201DOI Listing
February 2019
2 Reads

Outcomes after Listing for Liver Transplant in Patients with Acute-on-Chronic Liver Failure (ACLF): The Multicenter NACSELD Experience.

Liver Transpl 2019 Feb 5. Epub 2019 Feb 5.

University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Acute-on-Chronic Liver Failure (ACLF) characterized with ≥2 extra-hepatic organ failures in cirrhosis carries a high mortality. Outcomes of patients listed for liver transplant (LT) after ACLF and after LT are largely unknown. NACSELD (North American Consortium for the Study of End-Stage Liver Disease) prospectively enrolled 2,793 non-electively hospitalized patients with cirrhosis; 768 were LT-listed. Read More

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http://dx.doi.org/10.1002/lt.25426DOI Listing
February 2019
2 Reads

Relationship of Liver Stiffness with Congestion in Patients Presenting with Acute Decompensated Heart Failure.

J Card Fail 2019 Feb 2. Epub 2019 Feb 2.

Vinogradov City Clinical Hospital, Moscow, Russian Federation.

Objective: The significance of liver stiffness (LS) in the setting of cardiovascular congestion during the course of acute decompensated heart failure (ADHF) is under investigation. The aim of this study was to assess LS with transient elastography (TE) and its associations with volume overload by bioimpedance vector analysis (BIVA) in ADHF.

Methods And Results: TE (Fibroscan 502 Echosens, France) and BIVA (ABC-01 "Medass", Russia) were performed in the first 48 hours of admission and on the day of discharge in 149 ADHF patients without known primary chronic liver disease and acute hepatitis. Read More

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http://dx.doi.org/10.1016/j.cardfail.2019.01.020DOI Listing
February 2019
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The antagonistic effect of tamoxifen against d-galactosamine/lipopolysaccharide-induced acute liver failure is associated with reactivation of hepatic nuclear factor-κB.

Immunopharmacol Immunotoxicol 2019 Feb 5:1-7. Epub 2019 Feb 5.

a The Affiliated Ganzhou Hospital of Nanchang University , Ganzhou , Jiangxi , China.

Context: Tamoxifen (TAM) ameliorates D-galactosamine/lipopolysaccharide (Gal/LPS)-induced acute liver failure (ALF) through its antioxidative effect; thus, this study was designed to determine whether the effectiveness of TAM is related to nuclear factor-κB (NF-κB) reactivation.

Materials And Methods: Experimental mice were injected with TAM once daily for 3 consecutive days intraperitoneally (i.p). Read More

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http://dx.doi.org/10.1080/08923973.2019.1569044DOI Listing
February 2019
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Identification of Novel Regulatory Genes in APAP Induced Hepatocyte Toxicity by a Genome-Wide CRISPR-Cas9 Screen.

Sci Rep 2019 Feb 4;9(1):1396. Epub 2019 Feb 4.

Division of Experimental and Translational Genetics, University of Missouri Kansas City School of Medicine, Kansas City, USA.

Acetaminophen (APAP) is a commonly used analgesic responsible for more than half of acute liver failure cases. Identification of previously unknown genetic risk factors would provide mechanistic insights and novel therapeutic targets for APAP-induced liver injury. This study used a genome-wide CRISPR-Cas9 screen to evaluate genes that are protective against, or cause susceptibility to, APAP-induced liver injury. Read More

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http://dx.doi.org/10.1038/s41598-018-37940-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362041PMC
February 2019
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Technical Feasibility and Clinical Effectiveness of Transjugular Intrahepatic Portosystemic Shunt Creation in Pediatric and Adolescent Patients.

J Vasc Interv Radiol 2019 Feb;30(2):178-186.e5

Division of Interventional Radiology, Department of Radiology, University of Washington, Seattle, Washington; Seattle Children's Hospital, Seattle, Washington.

Purpose: To examine the technical feasibility and clinical efficacy of transjugular intrahepatic portosystemic shunt (TIPS) creation in children and adolescents.

Materials And Methods: Retrospective review was performed of 59 patients (mean age 12.6 y [range, 1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10510443183158
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http://dx.doi.org/10.1016/j.jvir.2018.10.003DOI Listing
February 2019
2 Reads
2.149 Impact Factor

ESPEN guideline on clinical nutrition in liver disease.

Clin Nutr 2019 Jan 16. Epub 2019 Jan 16.

Department for Clinical Nutrition, University of Hohenheim, Stuttgart, Germany.

This update of evidence-based guidelines (GL) aims to translate current evidence and expert opinion into recommendations for multidisciplinary teams responsible for the optimal nutritional and metabolic management of adult patients with liver disease. The GL was commissioned and financially supported by ESPEN. Members of the guideline group were selected by ESPEN. Read More

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http://dx.doi.org/10.1016/j.clnu.2018.12.022DOI Listing
January 2019
30 Reads

Massive generalized crystal-storing histiocytosis associated with extracellular crystalline nephropathy: clinical, immunohistochemical, and ultrastructural studies of a unique disorder and review of the literature.

CEN Case Rep 2019 Feb 2. Epub 2019 Feb 2.

Deparment of Internal Medicine, Hospital General Universitario Gregorio Marañón, C/. Doctor Esquerdo, 46, 28007, Madrid, Spain.

Crystal-storing histiocytosis (CSH) is a rare disorder characterized by the accumulation of nonneoplastic histiocytes containing intracytoplasmic crystallized immunoglobulins. In most cases, there is an associated underlying lymphoplasmacytic neoplasm expressing Ig kappa light chain. About 131 cases of CSH have been identified. Read More

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http://dx.doi.org/10.1007/s13730-019-00385-5DOI Listing
February 2019
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The impact of body mass index on perioperative outcomes after robotic liver resection.

J Robot Surg 2019 Feb 1. Epub 2019 Feb 1.

Southeastern Center for Digestive Disorder and Hepatopancreatobiliary Cancer, Advanced Minimally Invasive and Robotic Surgery, Florida Hospital Tampa, 3000 Medical Park Dr, Suite #500, Tampa, USA.

High body mass index (BMI) is associated with other multiple comorbidities such as non-alcoholic fatty liver disease, steatohepatitis, liver cirrhosis, and cardiopulmonary diseases, which can impact the perioperative outcomes following liver resection. We aimed to study the impact of BMI on perioperative outcomes after robotic liver resection. All the patients undergoing robotic liver resection between 2013 and 2017 were prospectively followed. Read More

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http://link.springer.com/10.1007/s11701-019-00923-4
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http://dx.doi.org/10.1007/s11701-019-00923-4DOI Listing
February 2019
3 Reads

The Synergistic Effect of Albumin on Terlipressin in Acute on Chronic Liver Failure with Acute Kidney Injury.

Hepatology 2019 Jan 31. Epub 2019 Jan 31.

Xenorm MedInfo Center, No. 30 Xue Yuan Road, Haidian District, Beijing, China.

We read with great interest, the trial conducted by Arora et al. in which the authors reported superiority of terlipressin over noradrenaline in treating patients with acute on chronic liver failure (ACLF) and acute kidney injury (AKI). In this study, patients receiving terlipressin had better clinical response and survival compared to those receiving noradrenaline. Read More

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http://dx.doi.org/10.1002/hep.30539DOI Listing
January 2019
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DRAM is Involved in Hypoxia/Ischemia-Induced Autophagic Apoptosis in Hepatocytes.

Aging Dis 2019 Feb 1;10(1):82-93. Epub 2019 Feb 1.

1Beijing You'an Hospital Affiliated with Capital Medical University, Beijing 100069, China.

Liver hypoxia/ischemia injury leads to acute liver injury, delayed graft dysfunction, and failure during liver transplantation. Previous studies showed that autophagy is involved in liver hypoxia/ischemia injury. Our and others' studies have found that the damage-regulated autophagy modulator (DRAM) could induce the autophagic apoptosis. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0210
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http://dx.doi.org/10.14336/AD.2018.0210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345327PMC
February 2019
2 Reads

Mutation in Gene Can Cause Syndromic Multisystem Autoimmune Disease With Acute Liver Failure.

Pediatrics 2019 Jan 31. Epub 2019 Jan 31.

Departments of Pediatrics, Gastroenterology, and Hepatology and

Pediatric intractable autoimmune hepatitis is rare and may be responsible for acute liver failure. Mutations in the itchy E3 ubiquitin protein ligase () gene (located on chromosome 20q11.22) can lead to a deficiency of the encoded protein, resulting in increased T-cell activity with lack of immune tolerance and manifestation of a complex systemic autoimmune disease. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2018-1554DOI Listing
January 2019
10 Reads

Erythropoietic Protoporphyria and X-Linked Protoporphyria: pathophysiology, genetics, clinical manifestations, and management.

Authors:
Manisha Balwani

Mol Genet Metab 2019 Jan 24. Epub 2019 Jan 24.

Department of Genetics and Genomic Sciences and Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States. Electronic address:

Erythropoietic Protoporphyria (EPP) and X-linked Protoporphyria (XLP) are rare, genetic photodermatoses resulting from defects in enzymes of the heme-biosynthetic pathway. EPP results from the partial deficiency of ferrochelatase, and XLP results from gain-of-function mutations in erythroid specific ALAS2. Both disorders result in the accumulation of erythrocyte protoporphyrin, which is released in the plasma and taken up by the liver and vascular endothelium. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10967192183064
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http://dx.doi.org/10.1016/j.ymgme.2019.01.020DOI Listing
January 2019
2 Reads

Elevated D-dimer is associated with increased 28-day mortality in acute-on-chronic liver failure in China: a retrospective study.

BMC Gastroenterol 2019 Jan 31;19(1):20. Epub 2019 Jan 31.

Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by profound disrupted coagulation and fibrinolysis. Fibrinolytic marker D-dimer is increased in critically ill patients with cirrhosis which is associated with poorer prognosis. We aim to determine the potential association of D-dimer with the 28-day mortality in ACLF patients. Read More

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http://dx.doi.org/10.1186/s12876-019-0941-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357416PMC
January 2019
1 Read