55 results match your criteria Acute Kidney Injury[Journal]


Ampicillin/sulbactam versus cefazolin plus aminoglycosides for antimicrobial prophylaxis in management of Gustilo type IIIA open fractures: A retrospective cohort study.

Injury 2022 Apr 20;53(4):1517-1522. Epub 2022 Jan 20.

Department of Orthopaedic Surgery, Hyogo Prefectural Kakogawa Medical Center, Hyogo 675-8555, Japan.

Background: The antibiotic regimens for prophylaxis in the management of open fractures remain controversial. Although the use of aminoglycosides is widely accepted for treatment of Gustilo type III open fractures, aminoglycosides are often avoided in patients with risk factors. This study aimed to compare efficacy and safety of two regimens, cephazolin plus aminoglycoside (amikacin or gentamicin) and ampicillin/sulbactam (ABPC/SBT), in patients with Gustilo type IIIA open fractures. Read More

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Chronic kidney disease and risk of postoperative cardiovascular events in elderly patients receiving hip fracture surgery.

Injury 2022 Feb 23;53(2):596-602. Epub 2021 Dec 23.

Department of Orthopaedics, Chinese PLA General Hospital, Beijing, China, 100853.

Introduction: The long-term risk of cardiovascular events caused by chronic kidney disease (CKD) is well described in the general population. Less is known concerning the risk of postoperative cardiovascular events in geriatric hip fracture patients with CKD.

Methods: This study involved patients at least 65 years of age who received surgery for acute hip fracture between January 2000 and April 2016. Read More

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February 2022

Relationship between creatine kinase and liver enzymes in war wounded with rhabdomyolysis.

Injury 2022 Jan 16;53(1):166-170. Epub 2021 Oct 16.

Percy Military Teaching Hospital, Department of Anesthesiology and intensive care unit, 101 avenue Henri Barbusse, 92140 Clamart, France.

Background: Rhabdomyolysis is a frequent complication in war wounded. Its complex pathophysiology suggests that it not only affects kidneys but also other organs such as the liver. The aim of this study was to evaluate the relationship between creatine kinase (CK) and liver enzymes in war wounded with rhabdomyolysis. Read More

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January 2022

Prediction of early acute kidney injury after trauma using prehospital systolic blood pressure and lactate levels: A prospective validation study.

Injury 2022 Jan 1;53(1):81-85. Epub 2021 Oct 1.

Department of Emergency and Critical Care Medicine, Wakayama Medical University, School of Medicine, Wakayama, Japan.

Background: Acute kidney injury (AKI) after trauma is a major complication independently associated with a prolonged hospital stay and increased mortality. We previously reported that the prehospital systolic blood pressure (SBP) and early hospital arterial lactate level, along with specific cut-off values, show good performance in the early prediction of AKI using AUC-ROC [1]. The purpose of this study was to prospectively validate whether or not these parameters are predictive of newly occurring AKI after trauma. Read More

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January 2022

Musculoskeletal injuries and management of victims from collapsed buildings in the 2016 Taiwan earthquake: Experiences in a tertiary medical center.

Injury 2021 Nov 5;52(11):3334-3339. Epub 2021 Sep 5.

Department of Orthopedics, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Orthopedic Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Skeleton Materials and Bio-compatibility Core Lab, Research Center of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Medical Device Innovation Center (MDIC), National Cheng Kung University Hospital, Tainan, Taiwan; Musculoskeletal Research Center, Innovation Headquarter, National Cheng Kung University, Tainan, Taiwan.. Electronic address:

Background: Previous studies have seldom focused on injury patterns, especially musculoskeletal injuries, caused by building collapse during earthquakes. The aim of this study was to investigate the musculoskeletal injury profiles and management of patients rescued from collapsed buildings in the 2016 Taiwan earthquake.

Methods: We conducted a retrospective study using the electronic medical record (EMR) system. Read More

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November 2021

Chronic kidney disease patients with intertrochanteric fracture have a high mortality rate.

Injury 2021 Aug 2;52(8):2350-2355. Epub 2021 Jun 2.

Department of Orthopedic Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea. Electronic address:

Aims: The prognosis of patients with chronic kidney disease (CKD) and intertrochanteric fractures is unclear. This study was aimed to analyze the mortality and complication rates among CKD patients with intertrochanteric femoral fractures and the risk factors of one-year mortality after surgery.

Patients And Methods: This retrospective cohort study included 49 patients diagnosed with grades III, IV, or V CKD who were surgically treated for an intertrochanteric fracture between January 2011 and February 2019 at a tertiary university hospital. Read More

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Falanga: The clinical correlates of surgical outcomes as a result of foot whipping in a resource poor setting.

Injury 2021 Oct 18;52(10):3139-3142. Epub 2021 Feb 18.

Ngwelezana Hospital, Department of Surgery, University of KwaZulu Natal, Province of KwaZulu-Natal, South Africa.

Background: Falanga is a punishment that involves hitting the bare soles of a person's feet. The consequences of this punishment may be limb and life-threatening. Post-traumatic acute kidney injury (AKI) secondary to rhabdomyolysis is a well-documented complication. Read More

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October 2021

Predictors of postoperative acute kidney injury in patients undergoing hip fracture surgery: A systematic review and meta-analysis.

Injury 2021 Mar 28;52(3):330-338. Epub 2020 Sep 28.

Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, China; Orthopaedic Institute, Medical College, Soochow University, Suzhou 215007, China. Electronic address:

Background: The present study aimed to summarize the predictors of acute kidney injury (AKI) in patients after hip surgery.

Methods: A literature search was performed using PubMed, EMBASE, Cochrane Library, and Web of Science for studies assessing the predictors of AKI after hip fracture surgery. Pooled odds ratio (OR) and mean difference (MD) of those who experienced AKI compared to those who did not were calculated for each variable. Read More

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Mob Justice in South Africa: A comparison of blunt trauma secondary to community and non-community assaults.

Injury 2020 Aug 22;51(8):1791-1797. Epub 2020 May 22.

University of KwaZulu Natal, Pietermaritzburg, KwaZulu Natal, South Africa; University of Witwatersrand, Johannesburg, Gauteng, South Africa. Electronic address:

Background: The phenomenon of extrajudicial "mob justice" and community assault (CA) has been documented in news reports and anecdotes from a number of low- and middle-income countries, but there is little literature on its burden on trauma systems. This study reviews a single center's management of CA victims and compares the spectrum of injuries seen following mob assault with those sustained via other forms of interpersonal violence (IPV).

Methods: Clinical data, injury details, and mortality among injured patients (age≥18) hospitalized in a South African tertiary referral center from 2012-2018 were abstracted. Read More

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Assessing risk factors of acute kidney injury and its impacts on mortality after hip fracture surgery.

Injury 2020 06 19;51(6):1406-1407. Epub 2020 Apr 19.

Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China.

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Complications following hip fracture: Results from the World Hip Trauma Evaluation cohort study.

Injury 2020 Jun 30;51(6):1331-1336. Epub 2020 Mar 30.

Oxford Trauma, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), Kadoorie Centre, University of Oxford, Oxford, OX3 9DU, United Kingdom; Oxford University Hospitals NHS Foundation Trust, Trauma Research, Kadoorie Centre, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom. Electronic address:

Introduction: Hip fractures are common in people over 60 years of age, and are associated with significant disability, morbidity and mortality. The aim of this study was to record the incidence of complications in the first 120 days following hip fracture.

Methods: The World Hip Trauma Evaluation (WHiTE) study is a multicentre, prospective cohort study conducted in National Health Service (NHS) hospitals in England and Wales. Read More

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Risk of severe acute kidney injury in multiple trauma patients: Risk estimation based on a national trauma dataset.

Injury 2020 Jan 9;51(1):45-50. Epub 2019 Nov 9.

Department of Medicine, Jersey Shore University Medical Center, Neptune, NJ, USA.

Introduction: The development of acute kidney injury (AKI) in trauma patients has been associated with almost three fold increase in overall mortality. However, there is a paucity of information of early recognition of risk factors of severe AKI in trauma patients examining the patient's demography, injury characteristics and comorbidities. The purpose of the study was early identification of risk factors of severe AKI. Read More

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January 2020

Acute kidney injury following hip fracture.

Injury 2019 Dec 4;50(12):2268-2271. Epub 2019 Oct 4.

Department of Urology, Tampere University Hospital and University of Tampere, Tampere, Finland.

Background: Hip fracture causes disability and excess mortality in the aging population. Acute kidney injury (AKI), is known to diminish survival of critically ill and trauma patients. AKI is also a common perioperative complication among surgical patients. Read More

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December 2019

Renal effects of three endoaortic occlusion strategies in a swine model of hemorrhagic shock.

Injury 2019 Nov 22;50(11):1908-1914. Epub 2019 Aug 22.

Clinical Investigation Facility, David Grant USAF Medical Center, Travis Air Force Base, CA, United States; Division of Emergency Medicine, University of Utah Health, Salt Lake City, UT, United States.

Introduction: Trauma patients are predisposed to kidney injury. We hypothesized that in shock, zone 3 REBOA would increase renal blood flow (RBF) compared to control and that a period of zone 3 occlusion following zone 1 occlusion would improve renal function compared to zone 1 occlusion alone.

Materials And Methods: Twenty-four anesthetized swine underwent hemorrhagic shock, 45 min of zone 1 REBOA (Z1, supraceliac), zone 3 REBOA (Z3, infrarenal), or no intervention (control) followed by resuscitation with shed blood and 5 h of critical care. Read More

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November 2019

Is early postoperative hypoalbuminemia really a risk factor for acute kidney injury after hip fracture surgery?

Injury 2019 02 28;50(2):616-617. Epub 2018 Dec 28.

Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.

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February 2019

Metabolic syndrome and hip fracture: Epidemiology and perioperative outcomes.

Injury 2018 Nov 8;49(11):2036-2041. Epub 2018 Sep 8.

University of Alabama at Birmingham Hospital, Department of Orthopaedic Surgery, 1313 13th St S, Birmingham, AL, 35205, United States.

Introduction: Hip fractures and metabolic syndrome (MetS) are becoming major global healthcare burdens as populations age. This study sought to determine the impact of MetS in hip fracture patients on perioperative outcomes following operative fixation or arthroplasty.

Methods: Data from the 2004-2014 Nationwide Inpatient Sample was used to select 3,348,207 discharges with hip fracture. Read More

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November 2018

Early postoperative hypoalbuminemia is a risk factor for postoperative acute kidney injury following hip fracture surgery.

Injury 2018 Aug 2;49(8):1572-1576. Epub 2018 May 2.

Department of Orthopaedic Surgery, Anam Hospital, Korea University College of Medicine, Seoul, South Korea. Electronic address:

Introduction: Acute kidney injury (AKI) is a common and serious complication after hip fracture surgery in older adults. Hypoalbuminemia is a known independent risk factor for AKI. However, few studies have investigated the relationship between early postoperative hypoalbuminemia and AKI after hip fracture surgery. Read More

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Assessment of 30-day mortality and complication rates associated with extended deep vein thrombosis prophylaxis following hip fracture surgery.

Injury 2018 Jun 19;49(6):1141-1148. Epub 2018 Mar 19.

Department of Orthopedics, Brown University Warren Alpert Medical School, 100 Butler Drive, Providence, RI, 02906, USA. Electronic address:

Background: DVT is a common complication following lower extremity surgery, occurring in up to 60% of patients undergoing hip fracture surgery without postoperative anticoagulation. The risk of fatal PE continues well-beyond two weeks postoperatively, thus extended DVT prophylaxis beyond 14 days may be warranted. This investigation sought to examine the association between prescription of extended DVT prophylaxis and 30-day postoperative complications following hip fracture surgery. Read More

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Acute Kidney Injury: It's not just the 'big' burns.

Injury 2018 Feb 16;49(2):213-218. Epub 2017 Nov 16.

Victorian Adult Burns Service, The Alfred, Melbourne, Australia; Department of Surgery, Central Clinical School, Monash University, Melbourne, Australia.

Background: Acute Kidney Injury (AKI) complicates the management of at least 25% of patients with severe burns and is associated with long term complications. Most research focuses on the patients with more severe burns, and whether the same factors are associated with the development of AKI in patients with burns between 10 and 19% total body surface area (TBSA) is unknown. The aims of this study were to examine the incidence of, and factors associated with, the development of AKI in patients with %TBSA≥10, as well as the relationship with hospital metrics such as length of stay (LOS). Read More

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February 2018

Assessing incidence and risk factors of acute kidney injury in traumatic patients.

Injury 2017 12 9;48(12):2888-2889. Epub 2017 Oct 9.

Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

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December 2017

Incidence and risk factors of acute kidney injury in the Japanese trauma population: A prospective cohort study.

Injury 2017 Oct 15;48(10):2145-2149. Epub 2017 Aug 15.

Department of Nephrology, Kurashiki Central Hospital, Kurashiki, 1-1-1 Miwa Kurashiki Okayama 710-8602, Japan.

Introduction: Previous studies have reported the prevalence and risk factors of acute kidney injury (AKI) in relatively young trauma patients. The aims of this study were to identify the prevalence and risk factors of AKI among older Japanese trauma patients.

Methods: We conducted a prospective observational study in the 8-bed intensive care unit (ICU) of a Japanese tertiary-care hospital. Read More

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October 2017

Erythropoietin attenuates experimental haemorrhagic shock-induced renal damage through an iNOS- dependent mechanism in male Wistar rats.

Injury 2017 Feb 4;48(2):262-269. Epub 2017 Jan 4.

Protein Chemistry Lab, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Aim: Erythropoietin (EPO) is shown to exert protective effects on different tissues in haemorrhagic shock (HS) states. Nitric oxide (NO), as a multifunctional signaling molecule, is implicated in diverse physiologic and pathologic processes. In order to understand the exact mechanism of EPO protection, in this study we evaluated the role of different NOS enzymes in the EPO signaling pathway in male rats. Read More

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February 2017

Age-related injury patterns in Spanish trauma ICU patients. Results from the RETRAUCI.

Injury 2016 Sep;47 Suppl 3:S61-S65

Servicio de Medicina Intensiva. Hospital General Universitario de Ciudad Real, Ciudad Real, Spain.

Background: Injury patterns may differ in trauma patients when age is considered. This information is relevant in the management of trauma patients and for planning preventive measures.

Methods: We included in the study all patients admitted for traumatic disease in the participating ICUs from November 23, 2012 to July 31, 2015 with complete records. Read More

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September 2016

Mild hypothermia attenuate kidney injury in canines with oleic acid-induced acute respiratory distress syndrome.

Injury 2016 Jul 3;47(7):1445-51. Epub 2016 May 3.

Department of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, PR China. Electronic address:

Background: Hypothermia may attenuate ventilator induced-lung injury in acute respiratory distress syndrome (ARDS). However, the impact of hypothermia on extra-pulmonary organ injury in ARDS remains unclear. The purpose of this study was to investigate whether hypothermia affects extra-pulmonary organ injury in a canine ARDS model induced by oleic acid. Read More

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Decreased glomerular filtration rate estimated by 2009 CKD-EPI equation predicts mortality in older hip fracture population.

Injury 2016 Jul 2;47(7):1536-42. Epub 2016 May 2.

Department of Geriatric Medicine, Seinäjoki Central Hospital, Finland. Electronic address:

Objective: We examined estimated glomerular filtration rate using the Chronic Kidney Disease Epidemiology equation (eGFRCDK-EPI), removal of urinary catheter during hospitalization and polypharmacy as predictors of mortality in older hip fracture patients.

Methods: Population-based prospective data were collected on 1425 consecutive hip fracture patients aged ≥65 years. Outcome was mortality at one year. Read More

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Antibiotic related acute kidney injury in patients treated for open fractures.

Injury 2016 Mar 23;47(3):653-7. Epub 2016 Jan 23.

Department of Orthopaedic Surgery, USC, Los Angeles, CA, United States.

Objective: Antibiotic administration during the treatment of open fractures has been shown to reduce infection rates and is considered a critical step in the management of these injuries. The purpose of this study was to determine if aminoglycoside administration during the treatment of open fractures leads to acute kidney injury.

Methods: Patient records at a level I trauma centre were reviewed for adult patients who presented in 2014 with open fractures were screened for inclusion. Read More

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Morbidity or mortality? Variations in trauma centres in the rescue of older injured patients.

Injury 2016 May 17;47(5):1091-7. Epub 2015 Dec 17.

Center for Surgery and Public Health, Harvard Medical School and Harvard T.H. Chan School of Public Health, Department of Surgery, Brigham & Women's Hospital, Boston, MA, USA. Electronic address:

Introduction: Prior analysis demonstrates improved survival for older trauma patients (age>64years) treated at trauma centres that manage a higher proportion of geriatric patients. We hypothesised that 'failure to rescue' (death after a complication during an in-hospital stay) may be responsible for part of this variation. The objective of the study was to determine if trauma centre failure to rescue rates are associated with the proportion of older trauma seen. Read More

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Implementing the Surgical Apgar Score in patients with trauma hip fracture.

Injury 2015 Nov 6;46 Suppl 6:S61-6. Epub 2015 Nov 6.

Department of Anaesthesiology, Reanimatology and Intensive Care, University Hospital Centre Zagreb, Zagreb, Croatia.

Background: Trauma hip fractures in elderly patients are associated with high postoperative long-term morbidity and mortality and premature death. The high mortality in these patients can be explained by various factors, including the fracture itself; the preoperative poor condition and comorbidities of these patients; the influence of stressors, such as surgery and type of anaesthesia, on the patient's condition; and the postoperative development of major complications, such as cardiac failure, pulmonary embolism, pneumonia, deep venous thrombosis and acute renal failure. Thus, the Surgical Apgar Score (SAS) could be a valuable tool for objective risk stratification of patients immediately after surgery, and to enable patients with higher risk to receive postoperative ICU care and good management both during and after the hospital stay. Read More

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November 2015

A study on the effect of cimetidine and L-carnitine on myoglobinuric acute kidney injury in male rats.

Injury 2015 Jul 11;46(7):1223-30. Epub 2015 Apr 11.

Histology Department, Faculty of Medicine, Cairo University, Giza, Egypt. Electronic address:

Myoglobinuric acute renal failure is the most important life threatening complication of rhabdomyolysis. Iron, free radicals, nitric oxide and cytochrome p450 are involved in the pathogenesis of mARF. The aim of this study is to compare the effect of cimetidine, l-carnitine and both agents together on mARF in rats. Read More

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Is fluid resuscitation with high-volume hydroxyethyl starch safe for the kidney in trauma patients?

Injury 2015 Aug 16;46(8):1698-9. Epub 2015 Mar 16.

Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

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