10,472 results match your criteria Acute Inflammatory Demyelinating Polyradiculoneuropathy


Guillain-Barre Syndrome Associated with SARS-CoV-2 Detection and a COVID-19 Infection in a Child.

J Pediatric Infect Dis Soc 2020 Jul 11. Epub 2020 Jul 11.

Faculty of Behavioral, Management and Social Sciences, Department Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.

Coronavirus disease (COVID-19) is caused by SARS-CoV-2. Physicians in China reported what is believed to be the first adult case of a SARS-CoV-2 infection associated with acute Guillain-Barré syndrome (GBS), followed by five adult Italian patients and another case in the United States of America. In the current report we present one of the first descriptions of an association of GBS and SARS-CoV-2 infection within a child. Read More

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http://dx.doi.org/10.1093/jpids/piaa086DOI Listing

A complex between the Zika virion and the Fab of a broadly cross-reactive neutralizing monoclonal antibody revealed by cryo-EM and single particle analysis at 4.1 Å resolution.

J Struct Biol X 2020 17;4:100028. Epub 2020 Jun 17.

School of Biological Sciences, Nanyang Technological University, Singapore.

Zika virus (ZIKV) recently emerged as a major public health concern because it can cause fetal microcephaly and neurological disease such as the Guillain-Barré syndrome. A particularly potent class of broadly neutralizing antibodies (nAbs) targets a quaternary epitope located at the interface of two envelope proteins monomers, exposed at the surface of the mature virion. This "E-dimer-dependent epitope" (EDE), comprises the fusion loop of one monomer at the tip of domain II of E and a portion of the domains I and III of the adjacent monomer. Read More

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http://dx.doi.org/10.1016/j.yjsbx.2020.100028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337043PMC

Guillain-Barré syndrome related to SARS-CoV-2 infection.

Authors:

Neurol Neuroimmunol Neuroinflamm 2020 Sep 9;7(5). Epub 2020 Jul 9.

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http://dx.doi.org/10.1212/NXI.0000000000000850DOI Listing
September 2020

Spectrum of Neurological Manifestations in Covid-19: A Review.

Authors:
Ravindra K Garg

Neurol India 2020 May-Jun;68(3):560-572

Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.

COVID-19, in most patients, presents with mild flu-like illness. Elderly patients with comorbidities, like hypertension, diabetes, or lung and cardiac disease, are more likely to have severe disease and deaths. Neurological complications are frequently reported in severely or critically ill patients with comorbidities. Read More

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http://dx.doi.org/10.4103/0028-3886.289000DOI Listing

Is Guillain-Barrè syndrome triggered by SARS-CoV-2? Case report and literature review.

Neurol Sci 2020 Jul 9. Epub 2020 Jul 9.

Division of Neurosurgery, Department of Biotechnology and Life Sciences, University of Insubria, Via Guicciardini, 9, 21100, Varese, Italy.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the infectious agent responsible for coronavirus disease 2019 (COVID-19). Respiratory and gastrointestinal manifestations of SARS-CoV-2 are well described, less defined is the clinical neurological spectrum of COVID-19. We reported a case of COVID-19 patient with acute monophasic Guillain-Barré syndrome (GBS), and a literature review on the SARS-CoV-2 and GBS etiological correlation. Read More

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http://dx.doi.org/10.1007/s10072-020-04553-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343406PMC

A Brain-Heart Interaction: Bickerstaff's brainstem encephalitis with Takotsubo Cardiomyopathy.

QJM 2020 Jul 8. Epub 2020 Jul 8.

Division of Neurology, Ng Teng Fong General Hospital, Singapore.

Introduction: Bickerstaff's brainstem encephalitis (BBE) is a neurological condition characterised by ataxia, opthalmoplegia and altered sensorium. Neurological diseases, such as Guillain-Barre syndrome, have previously been reported in association with Takotsubo cardiomyopathy. We describe a case of Takotsubo cardiomyopathy associated with BBE. Read More

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http://dx.doi.org/10.1093/qjmed/hcaa218DOI Listing

Guillain-Barré syndrome associated with COVID-19 infection: a case from the UK.

BMJ Case Rep 2020 Jul 8;13(7). Epub 2020 Jul 8.

Department of Neurology, University Hospitals of Leicester NHS Trust, Leicester, UK.

Originating from Wuhan, China, COVID-19 has rapidly spread worldwide. Neurological manifestations are more commonly associated with severe COVID-19 infection. Guillain-Barré syndrome (GBS) is a rare immune-mediated postinfectious neuropathy. Read More

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http://dx.doi.org/10.1136/bcr-2020-236536DOI Listing

The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings.

Brain 2020 Jul 8. Epub 2020 Jul 8.

University College London, Queen Square Institute of Neurology, London, UK.

Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. Responding to this, a weekly virtual coronavirus disease 19 (COVID-19) neurology multi-disciplinary meeting was established at the National Hospital, Queen Square, in early March 2020 in order to discuss and begin to understand neurological presentations in patients with suspected COVID-19-related neurological disorders. Detailed clinical and paraclinical data were collected from cases where the diagnosis of COVID-19 was confirmed through RNA PCR, or where the diagnosis was probable/possible according to World Health Organization criteria. Read More

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http://dx.doi.org/10.1093/brain/awaa240DOI Listing

High proportion of Guillain-Barré syndrome associated with chikungunya in Northeast Brazil.

Neurol Neuroimmunol Neuroinflamm 2020 Sep 6;7(5). Epub 2020 Jul 6.

From the Universidade de São Paulo (A.d.M.B.M., A.C.F., C.S.P., C.M.R.), Instituto de Medicina Tropical, Faculdade de Medicina; Hospital Geral de Fortaleza (F.M.M.C., C.L.R.), Serviço de Neurologia, CE; Universidade de Fortaleza (F.M.M.C., D.L.M., J.K.B.C.), Programa de Pós-Graduação em Ciências Médicas, CE; Universidade de Campinas (A.D.d.R.L., L.M.B.d.S., F.V.G.), Instituto de Biologia, SP; Universidade de São Paulo (D.L.A.E., B.A.L.d.F.), Faculdade de Medicina de Ribeirão Preto; Instituto de Infectologia Emilio Ribas (A.C.P.d.O.), São Paulo; and Laboratório de Virologia (LIMHC 52) (C.M.R.), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil.

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http://dx.doi.org/10.1212/NXI.0000000000000833DOI Listing
September 2020

[Experience of treating facial neuritis, unexplained limb weakness, cervical spondylosis, acute myelitis, acute radiculitis, Guillain Barre syndrome, multiple sclerosis, myasthenia gravis, motor neuron disease, dermatomyositis with Xiaoxuming Decoction].

Authors:
Xing-Jiang Xiong

Zhongguo Zhong Yao Za Zhi 2020 Jun;45(12):2735-2751

Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing 100053, China.

Xiaoxuming Decoction is an ancient classic herbal formula for the treatment of stroke. In ancient times, the connotation of stroke was very extensive, including facial neuritis, acute cerebral infarction, acute cerebral hemorrhage, sequelae of cerebral hemorrhage, unexplained weakness of limbs, cervical spondylosis, acute myelitis, acute radiculitis, Guillain Barre syndrome, multiple sclerosis, myasthenia gravis, motor neuron disease, dermatomyositis, hypokalemic paralysis peripheral neuritis. It has been identified that: ①Xiaoxuming Decoction is very common in the treatment of cerebrovascular diseases, such as cerebral infarction, cerebral hemorrhage and other cerebrovascular diseases, facial neuritis, acute myelitis, acute radiculitis, Guillain Barre syndrome, unexplained limb weakness, multiple sclerosis, motor neuron disease, myasthenia gravis, and rheumatic and immune system diseases, such as dermatomyositis, and can not only alleviate symptoms, but also improve prognosis and the long-term survival rate. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200328.501DOI Listing

[Conotation of ancient "stroke" and Qianyin Yaofang Xiaoxuming Decoction treating cerebral infarction and cerebral hemorrhage].

Authors:
Xing-Jiang Xiong

Zhongguo Zhong Yao Za Zhi 2020 Jun;45(12):2725-2734

Guang'anmen Hospital,China Academy of Chinese Medical Sciences Beijing 100053,China.

Xiaoxuming Decoction is the ancient classic herbal formulae for the treatment of stroke. Before the Han and Tang Dynasties, Xiaoxuming Decoction was highly praised by doctors of all dynasties as the "No.1 prescription of internal medicine". Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200316.501DOI Listing

Posterior reversible encephalopathy in a GT1a positive oculopharyngeal variant of Guillain-Barré syndrome: A case-report and review of the literature.

Clin Neurol Neurosurg 2020 Jun 22;196:106037. Epub 2020 Jun 22.

Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.

Guillain-Barre syndrome (GBS) is the most common cause of acute flaccid paralysis and its incidence increases with age, although all age groups can be affected. The cranial subtypes of GBS account for approximately 5% of cases. Posterior reversible encephalopathy syndrome (PRES) is an acute neurological disorder, mostly reversible but with increased morbidity with permanent neurological sequelae in severe cases. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.106037DOI Listing

Zika virus induces oxidative stress and decreases antioxidant enzyme activities in vitro and in vivo.

Virus Res 2020 Jul 2;286:198084. Epub 2020 Jul 2.

Programa de Pós Graduação em Ciências Biológicas, Núcleo de Pesquisas em Ciências Biológicas, NUPEB, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil; Departamento de Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil. Electronic address:

The first outbreak of Zika virus (ZIKV) infection in the Americas, especially in Brazil, was reported in 2015. Fever, headache, rash, and conjunctivitis are the common symptoms of ZIKV infection. Unexpected clinical outcomes, such as microcephaly and Guillain-Barré syndrome, have also been reported. Read More

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http://dx.doi.org/10.1016/j.virusres.2020.198084DOI Listing

Neurological associations of COVID-19.

Lancet Neurol 2020 Jul 2. Epub 2020 Jul 2.

National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; The Walton Centre National Health Service (NHS) Foundation Trust, Liverpool, UK; Tropical and Infectious Diseases Unit, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK. Electronic address:

Background: The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is of a scale not seen since the 1918 influenza pandemic. Although the predominant clinical presentation is with respiratory disease, neurological manifestations are being recognised increasingly. On the basis of knowledge of other coronaviruses, especially those that caused the severe acute respiratory syndrome and Middle East respiratory syndrome epidemics, cases of CNS and peripheral nervous system disease caused by SARS-CoV-2 might be expected to be rare. Read More

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http://dx.doi.org/10.1016/S1474-4422(20)30221-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332267PMC

Intermolecular interactions of cn-716 and acyl-KR-aldehyde dipeptide inhibitors against Zika virus.

Phys Chem Chem Phys 2020 Jul 3. Epub 2020 Jul 3.

Departamento de Biofísica e Farmacologia, Universidade Federal do Rio Grande do Norte, 59072-970, Natal, RN, Brazil.

The emergent Zika virus (ZIKV) infection has become a threat to global health due to its association with severe neurological abnormalities, namely Guillain-Barré Syndrome (GBS) in adults and Congenital Zika virus Syndrome (CZS) in neonates. Many studies are nowadays being conducted to find an effective antiviral drug against ZIKV. In particular, NS2B-NS3 protease is an attractive drug target due to its essential function in viral replication, although a drug is not yet commercially available. Read More

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http://dx.doi.org/10.1039/d0cp02254cDOI Listing

Guillain-Barré Syndrome as a Neurological Complication of Novel COVID-19 Infection: A Case Report and Review of the Literature.

Neurologist 2020 Jul;25(4):101-103

Department of Neurology, Bou Ali Sina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.

Introduction: The novel coronavirus (COVID-19) is a global pandemic. Although the main clinical manifestation of COVID-19 is respiratory involvement, there is evidence suggesting the neuroinvasive potential of COVID-19. There are limited reports of neurological complications of COVID-19 infection in the literature. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000291DOI Listing

Safety of Recombinant Influenza Vaccine Compared to Inactivated Influenza Vaccine in Adults: An Observational Study.

Open Forum Infect Dis 2020 Jun 20;7(6):ofaa179. Epub 2020 May 20.

Kaiser Permanente Vaccine Study Center, Oakland, California, USA.

Background: Recombinant trivalent influenza vaccine (RIV3) was initially licensed in 2013 and approved for all adults ≥18 in 2014. This study evaluated the safety of RIV3 compared with trivalent standard-dose, inactivated influenza vaccine (IIV3) in Kaiser Permanente Northern California (KPNC).

Methods: This Phase 4 observational, postmarketing safety study included persons ≥18 years vaccinated with RIV3 or IIV3 in KPNC during the 2015-2016 influenza season. Read More

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http://dx.doi.org/10.1093/ofid/ofaa179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316363PMC

Recurrent angioedema, Guillain-Barré, and myelitis in a girl with systemic lupus erythematosus and CD59 deficiency syndrome.

Auto Immun Highlights 2020 Dec 29;11(1). Epub 2020 Jun 29.

Department of Pediatric Neurology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: CD59 deficiency is a congenital mutation disorder in complement pathway which can present with various manifestations.

Case Presentation: Herein, we presented an adolescent 16-years-old girl with recurrent attacks of Guillain-Barre in early childhood and then recurrent attacks of angioedema, paresthesia, and myelitis. Finally, she presented with quadriplegia, malar rash, proteinuria, lymphopenia, and high titer of antinuclear antibody. Read More

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http://dx.doi.org/10.1186/s13317-020-00132-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322911PMC
December 2020

Pneumococcal Meningitis Complicated by Spinal Cord Dysfunction and Acute Polyradiculopathy.

Ochsner J 2020 ;20(2):219-221

Department of Medicine, Interfaith Medical Center, Brooklyn, NY.

Meningitis caused by is associated with devastating clinical outcomes. A considerable number of patients will develop long-term neurologic complications. Hearing loss, diffuse brain edema, and hydrocephalus are frequently encountered. Read More

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http://dx.doi.org/10.31486/toj.18.0153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310179PMC
January 2020

COVID-19 Infection and Neurological Complications: Present Findings and Future Predictions.

Neuroepidemiology 2020 Jul 1:1-6. Epub 2020 Jul 1.

Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari "Aldo Moro"Bari, "Pia Fondazione Cardinale G. Panico", Tricase, Italy.

The present outbreak caused by SARS-CoV-2, an influenza virus with neurotropic potential, presents with neurological manifestations in a large proportion of the affected individuals. Disorders of the central and peripheral nervous system are all present, while stroke, ataxia, seizures, and depressed level of consciousness are more common in severely affected patients. People with these severe complications are most likely elderly with medical comorbidities, especially hypertension and other vascular risk factors. Read More

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http://dx.doi.org/10.1159/000508991DOI Listing

Guillain-Barré Syndrome following a series of novel therapies adapting the gold-standard in the era of immune priming.

J Neuroimmunol 2020 May 21;346:577267. Epub 2020 May 21.

Department of Medical Oncology, Immune Therapy Program, University Health Network, Toronto, ON, Canada.

Over the past two decades, there has been a fundamental shift away from traditional cytotoxic chemotherapy towards the identification, and subsequent suppression of specific oncogenes. Immunotherapy and targeted therapy prime the immune system, potentially leading to deleterious side effects. The following case of Guillain-Barré Syndrome (GBS) emphasizes the importance of considering every agent when iatrogenic toxicity is suspected. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2020.577267DOI Listing

A large scale waterborne Campylobacteriosis outbreak, Havelock North, New Zealand.

J Infect 2020 Jun 29. Epub 2020 Jun 29.

Hawke's Bay District Health Board, New Zealand.

Background: We describe the investigation of a Campylobacter outbreak linked to contamination of an untreated, groundwater derived drinking water supply.

Methods: We analysed epidemiological data collected from clinician-confirmed diarrheal cases and estimated the total burden of Havelock North cases using an age-adjusted cross-sectional telephone survey. Campylobacter isolates from case fecal specimens, groundwater samples, and sheep fecal specimens from paddocks adjacent to the drinking water source were whole genome sequenced. Read More

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http://dx.doi.org/10.1016/j.jinf.2020.06.065DOI Listing

Axonal degeneration in Guillain-Barré syndrome: a reappraisal.

Authors:
José Berciano

J Neurol 2020 Jun 30. Epub 2020 Jun 30.

Professor Emeritus of Neurology, Service of Neurology, University Hospital "Marqués de Valdecilla (IDIVAL)", "Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)", University of Cantabria, Santander, Spain.

The aim of this review was to analyse the pathophysiology of axonal degeneration in Guillain-Barré syndrome (GBS) with emphasis on early stages (≤ 10 days after onset). An overview of experimental autoimmune neuritis (EAN) models is provided. Originally GBS and acute inflammatory demyelinating polyneuropathy were equated, presence of axonal degeneration being attributed to a "bystander" effect. Read More

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http://dx.doi.org/10.1007/s00415-020-10034-yDOI Listing

Significance of Brighton Criteria in the Early Diagnosis and Management of Guillain-Barré Syndrome.

Cureus 2020 May 27;12(5):e8318. Epub 2020 May 27.

Pharmacology, Shifa College of Medicine, Islamabad, PAK.

Guillain-Barré syndrome (GBS) is a rare but severe autoimmune disease and the usage of the Brighton criteria can be a source of great help in resource-limited settings. It encompasses all ages. Late diagnosis of GBS can have a significant negative impact on the prognosis. Read More

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http://dx.doi.org/10.7759/cureus.8318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320636PMC

Immunoadsorption and Plasma Exchange in Seropositive and Seronegative Immune-Mediated Neuropathies.

J Clin Med 2020 Jun 27;9(7). Epub 2020 Jun 27.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

The inflammatory neuropathies are disabling conditions with diverse immunological mechanisms. In some, a pathogenic role for immunoglobulin G (IgG)-class autoantibodies is increasingly appreciated, and immunoadsorption (IA) may therefore be a useful therapeutic option. We reviewed the use of and response to IA or plasma exchange (PLEx) in a cohort of 41 patients with nodal/paranodal antibodies identified from a total of 573 individuals with suspected inflammatory neuropathies during the course of routine diagnostic testing (PNAb cohort). Read More

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http://dx.doi.org/10.3390/jcm9072025DOI Listing

Guillain-Barré syndrome variants: An unusual cause of subjective tongue swelling.

Emerg Med Australas 2020 Jun 29. Epub 2020 Jun 29.

Department of Emergency Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1111/1742-6723.13572DOI Listing

Neurological Consequences of 2019-nCoV Infection: A Comprehensive Literature Review.

Cureus 2020 Jun 24;12(6):e8790. Epub 2020 Jun 24.

Medicine, Windsor University School of Medicine, Cayon, KNA.

First identified in November 2019 in Hubei Province, the coronavirus disease of 2019 (COVID-19) caused by SARS-CoV-2 soon spread worldwide to become a global health pandemic. The COVID-19 preferentially damages the respiratory system that produces symptoms such as fever, cough, and shortness of breath. However, the infection often tends to disseminate to involve various organ systems. Read More

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http://dx.doi.org/10.7759/cureus.8790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317136PMC

Signals and trends of Guillain-Barré syndrome after the introduction of live-attenuated vaccines for influenza in the US and South Korean adverse event reporting systems.

Vaccine 2020 Jun 26. Epub 2020 Jun 26.

School of Pharmacy, Sungkyunkwan University, 2066 Seobu-to, Jangan-gu, Suwon, Gyeong gi-do, South Korea. Electronic address:

Background: With the advent of live-attenuated, quadrivalent, and cell-cultured vaccines for influenza, there have been discussions on the safety of these vaccines compared to conventional vaccines (such as inactivated, trivalent, and egg-cultured vaccines) because of the development of neurological adverse events (AEs). This study aimed to compare the trends and safety signals in the AE reporting systems of the US and South Korea and, more particularly, to evaluate the association between influenza vaccination and Guillain-Barré syndrome (GBS).

Methods: In total, 400,535 AE reports from the US Vaccine Adverse Event Reporting System (VAERS) and 28,766 AE reports from the Korea Adverse Event Reporting System (KAERS) between 2005 and 2017 were assessed. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.06.038DOI Listing

Recurrent Guillain-Barré and Fisher Syndromes in Two Patients Who Were Subsequently Diagnosed with Aplastic Anemia.

Case Rep Neurol 2020 May-Aug;12(2):148-152. Epub 2020 May 28.

Division of Cerebrovascular Medicine and Neurology, Clinical Research Institute, National Hospitalization Organization, Kyushu Medical Center, Fukuoka, Japan.

Guillain-Barré (GBS) and Fisher (FS) syndromes rarely recur and the characteristics of recurrence have not been fully elucidated. We describe the cases of 2 patients with GBS or FS that recurred more than twice and who were subsequently diagnosed with aplastic anemia. Case 1 was a 66-year-old man who was diagnosed with aplastic anemia 10 months before admission with limb ataxia and a sensory disturbance of the distal limbs that developed 3 days after an upper respiratory tract infection. Read More

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http://dx.doi.org/10.1159/000507778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315140PMC

Understanding hyper-reflexia in acute motor axonal neuropathy (AMAN).

Neurophysiol Clin 2020 Jun 25. Epub 2020 Jun 25.

Department of Neuroscience, Imaging and Clinical Sciences, University "G. d'Annunzio", Chieti-Pescara, Italy.

Hyper-reflexia is occasionally seen in acute motor axonal neuropathy (AMAN), but its pathophysiology is unclear. We report a patient with AMAN following Campylobacter jejuni enteritis, who showed generalized hyper-reflexia, bilateral Hoffmann sign and right Babinski sign. MRI and transcranial magnetic stimulation of the motor cortex disclosed no corticospinal tract involvement. Read More

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http://dx.doi.org/10.1016/j.neucli.2020.05.004DOI Listing

Guillain-Barré syndrome in a patient infected with SARS-CoV-2, a case report.

J Neuroimmunol 2020 Jun 20;346:577294. Epub 2020 Jun 20.

Tabriz University of Medical Sciences, Iran.

Background: The COVID-19 is a novel condition affecting all the world, so every manifestation of disease should be reported. Neurologic manifestations of the disease are increasingly identified and this will help clinician to improve their diagnostic and therapeutic skills in dealing with COVID-19 patients.

Case: In this article we report a 41-year-old male that developed ascending paresthesia and paralysis following infection with SARS-CoV-2 virus. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2020.577294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305747PMC

Neurological features of COVID-19 and their treatment: a review.

Drugs Context 2020 11;9. Epub 2020 Jun 11.

Unit of Neurology, San Luca Hospital, Lucca, Italy.

Severe acute respiratory syndrome-correlated new coronavirus (SARS-Cov-2) infection may result in neurological signs and symptoms through different mechanisms. Although direct infection of the central nervous system is uncertain or very rare and the para-infectious complications (e.g. Read More

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http://dx.doi.org/10.7573/dic.2020-5-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295105PMC

COVID-19-Associated Bifacial Weakness with Paresthesia Subtype of Guillain-Barré Syndrome.

AJNR Am J Neuroradiol 2020 Jun 25. Epub 2020 Jun 25.

Radiology and Imaging Sciences (A.E.C., N.A.K.)

We report a case of bifacial weakness with paresthesia, a recognized Guillain-Barré syndrome subtype characterized by rapidly progressive facial weakness and paresthesia without ataxia or other cranial neuropathies, which was temporally associated with antecedent coronavirus 2019 (COVID-19). This case highlights a potentially novel but critically important neurologic association of the COVID-19 disease process. Herein, we detail the clinicoradiologic work-up and diagnosis, clinical course, and multidisciplinary medical management of this patient with COVID-19. Read More

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http://dx.doi.org/10.3174/ajnr.A6654DOI Listing

Meta-analysis of the risk of autoimmune thyroiditis, Guillain-Barré syndrome, and inflammatory bowel disease following vaccination with AS04-adjuvanted human papillomavirus 16/18 vaccine.

Pharmacoepidemiol Drug Saf 2020 Jun 24. Epub 2020 Jun 24.

Research and Development, GSK, Wavre, Belgium.

Purpose: To assess the risk of three autoimmune diseases - autoimmune thyroiditis (AIT), Guillain-Barré syndrome (GBS), and inflammatory bowel disease (IBD) - in females following AS04-HPV-16/18 vaccination.

Methods: This meta-analysis included data from 18 randomized controlled trials, one cluster-randomized trial, two large observational retrospective cohort studies, and one case-control study. Following vaccination, a risk window of 2 years was defined for AIT and IBD and 42 days for GBS. Read More

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http://dx.doi.org/10.1002/pds.5063DOI Listing

Influenza-associated Fulminant Myocarditis Complicated by Guillain-Barré Syndrome.

Intern Med 2020 Jun 23. Epub 2020 Jun 23.

Division of Cardiology, Shimane University Faculty of Medicine, Japan.

We herein report the case of a 47-year-old woman who was admitted with weakness and numbness of the limbs and dyspnea after being infected with influenza virus A. She had a history of Guillain-Barré syndrome (GBS) 7 years prior to this presentation. On admission, she was in shock, and transthoracic echocardiography showed severely reduced left-ventricular function. Read More

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http://dx.doi.org/10.2169/internalmedicine.4950-20DOI Listing

Safety of BRAF+MEK Inhibitor Combinations: Severe Adverse Event Evaluation.

Cancers (Basel) 2020 Jun 22;12(6). Epub 2020 Jun 22.

Ella Lemelbaum Institute for Immuno-oncology, Sheba Medical Center, Ramat-Gan 526260, Israel.

The selective BRAF and MEK inhibitors (BRAFi+MEKi) have substantially improved the survival of melanoma patients with BRAF V600 mutations. However, BRAFi+MEKi can also cause severe or fatal outcomes. We aimed to identify and compare serious adverse events (sAEs) that are significantly associated with BRAFi+MEKi. Read More

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http://dx.doi.org/10.3390/cancers12061650DOI Listing

Progress toward the Development of Glycan-Based Vaccines against Campylobacteriosis.

ACS Infect Dis 2020 Jul 9. Epub 2020 Jul 9.

Centre Armand-Frappier Santé Biotechnologie, Institut national de la recherche scientifique (INRS), 531, boul. des Prairies, Laval, Québec H7V 1B7, Canada.

As one of the main causes of bacterial diarrhea and a major risk factor for triggering Guillain-Barré autoimmune syndrome, campylobacteriosis, that is, spp. infections, represents a major health issue worldwide. There is thus a pressing need for developing an effective and broad-coverage campylobacteriosis vaccine. Read More

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http://dx.doi.org/10.1021/acsinfecdis.0c00332DOI Listing

Chikungunya encephalitis: report of a fatal case in Northeastern Brazil.

Rev Inst Med Trop Sao Paulo 2020 17;62:e40. Epub 2020 Jun 17.

Universidade Federal de Pernambuco, Programa de Pós Graduação em Medicina Tropical, Recife, Pernambuco, Brazil.

Chikungunya, a viral infection that presents with fever, rash and polyarthritis, is usually an acute febrile illness. Uncommon neurological manifestations include meningoencephalitis, encephalitis, myelitis, Guillain-Barre syndrome, myelopathy and neuropathy. During an outbreak of the disease in La Reunion Island, abnormalities were observed in the magnetic resonance imaging (MRI) of patients with encephalitis and acute disseminated encephalomyelitis, showing bilateral, frontoparietal, white matter lesions with restricted diffusion, similar to our case. Read More

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http://dx.doi.org/10.1590/S1678-9946202062040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304265PMC
June 2020
0.907 Impact Factor

High-Dose Inactivated Influenza Vaccine Quadrivalent for Older Adults.

Authors:
Elias B Chahine

Ann Pharmacother 2020 Jun 24:1060028020935645. Epub 2020 Jun 24.

Lloyd L. Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, FL, USA.

To review the efficacy and safety of the high-dose inactivated influenza vaccine quadrivalent (HD-IIV4) in the prevention of influenza in older adults. A literature search was performed using PubMed and Google Scholar with the search terms , and . Other resources included the Centers for Disease Control and Prevention (CDC), the prescribing information, and the manufacturer's website. Read More

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http://dx.doi.org/10.1177/1060028020935645DOI Listing

Guillain-Barré syndrome in the COVID-19 era: another occasional cluster?

J Neurol 2020 Jun 23. Epub 2020 Jun 23.

Department of Rehabilitation, Hôpital du Jura, Porrentruy, Switzerland.

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http://dx.doi.org/10.1007/s00415-020-10005-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309426PMC

Young woman with Guillain-Barré syndrome and cervical transverse myelitis-A new GBS variant, not coincidence.

Clin Case Rep 2020 Jun 21;8(6):1048-1052. Epub 2020 Apr 21.

Department of Neurology White Memorial Medical Center Los Angeles CA USA.

A case of antibody proven Guillain Barré Syndrome in a previously healthy young female with extra clinical features, scans, and physical exam findings consistent with cervical spine and cervical medullary junction myelitis, together a new variant to consider. Read More

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http://dx.doi.org/10.1002/ccr3.2818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303867PMC

Zika virus in Brazil and worldwide: a narrative review.

Paediatr Int Child Health 2020 Jun 24:1-8. Epub 2020 Jun 24.

Department of Paediatrics, School of Medicine, Federal University of Rio De Janeiro , Rio De Janeiro, Brazil.

Background: In the past 5 years, the Zika virus (ZIKV) has gone from being associated with mild infection to one of the most studied viruses worldwide. Between 2015 and 2016, the first reports of pregnant women with confirmed and/or suspected ZIKV infection described fetuses and newborns with severe congenital malformations, in particular microcephaly and central nervous system malformations, leading to a strong suspicion of its association with the virus. Despite all the knowledge rapidly acquired since the beginning of the ZIKV outbreak, many questions are still to be answered and further studies on the infection and its consequences are required. Read More

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http://dx.doi.org/10.1080/20469047.2020.1776044DOI Listing

Forced Zika Virus Infection of Leads to Limited Virus Accumulation in Mosquito Saliva.

Viruses 2020 Jun 19;12(6). Epub 2020 Jun 19.

Laboratory of Virology, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.

Zika virus (ZIKV) is a mosquito-borne pathogen that caused a large outbreak in the Americas in 2015 and 2016. The virus is currently present in tropical areas around the globe and can cause severe disease in humans, including Guillain-Barré syndrome and congenital microcephaly. The tropical yellow fever mosquito, , is the main vector in the urban transmission cycles of ZIKV. Read More

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http://dx.doi.org/10.3390/v12060659DOI Listing

7-Deaza-7-Fluoro-2'-C-Methyladenosine Inhibits Zika virus Infection and Viral-induced Neuroinflammation.

Antiviral Res 2020 Jun 20:104855. Epub 2020 Jun 20.

Department of Biochemistry and Immunology, And(2)Research Center for Drug Development, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Zika virus (ZIKV) has gained a lot of attention in the past few years due to its rapid spread worldwide and its close association to severe neurological outcomes, such as microcephaly and Guillain-Barre syndrome. In this study, the in vitro and in vivo anti-ZIKV activity of 7-deaza-7-fluoro-2'-C-methyl-adenosine (DFMA) was evaluated. In vitro, using primary mouse neuronal cells and human neural stem cells infected by ZIKV, treatment with DFMA resulted in impaired viral replication and protection against virus-induced cell death. Read More

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http://dx.doi.org/10.1016/j.antiviral.2020.104855DOI Listing

Neurological Manifestations of COVID-19 (SARS-CoV-2): A Review.

Front Neurol 2020 22;11:518. Epub 2020 May 22.

Southside Hospital Northwell Health, New York, NY, United States.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with many neurological symptoms but there is a little evidence-based published material on the neurological manifestations of COVID-19. The purpose of this article is to review the spectrum of the various neurological manifestations and underlying associated pathophysiology in COVID-19 patients. We conducted a review of the various case reports and retrospective clinical studies published on the neurological manifestations, associated literature, and related pathophysiology of COVID-19 using PUBMED and subsequent proceedings. Read More

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http://dx.doi.org/10.3389/fneur.2020.00518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257377PMC

The Neurologic Manifestations of Coronavirus Disease 2019 Pandemic: A Systemic Review.

Front Neurol 2020 19;11:498. Epub 2020 May 19.

Department of Neurology, China Medical University Hospital, Taichung, Taiwan.

Review and integrate the neurologic manifestations of the Coronavirus Disease 2019 (COVID-19) pandemic, to aid medical practitioners who are combating the newly derived infectious disease. We reviewed the clinical research, consisting of mainly case series, on reported neurologic manifestations of COVID-19. We also reviewed basic studies to understand the mechanism of these neurologic symptoms and signs. Read More

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http://dx.doi.org/10.3389/fneur.2020.00498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248254PMC

Comparative safety of high-dose versus standard-dose influenza vaccination in patients with end-stage renal disease.

Vaccine 2020 Jul 19;38(33):5178-5186. Epub 2020 Jun 19.

Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

Background: High-dose influenza vaccine (HDV) is an alternative vaccination strategy in patients with end-stage renal disease (ESRD), though the safety of HDV has not been evaluated in this population. The objective of this study was to estimate the relative occurrence of adverse vaccine reactions in patients with ESRD following vaccination with HDV compared with standard-dose influenza vaccine (SDV).

Methods: Using data from the United States Renal Data System, we identified patients with ESRD aged ≥ 65 years at influenza vaccination during yearly influenza seasons from 2010 through 2016. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332402PMC

Guillain-Barré syndrome associated with SARS-CoV-2 infection. Comments after 16 published cases.

Neurologia 2020 Jun 8. Epub 2020 Jun 8.

Servicio de Neurología, CINAC Puerta del Sur, Móstoles, Madrid, España; Facultad de Medicina, CEU, Madrid, España.

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http://dx.doi.org/10.1016/j.nrl.2020.06.002DOI Listing

Reverse genetic approaches for the development of Zika vaccines and therapeutics.

Curr Opin Virol 2020 Jun 18;44:7-15. Epub 2020 Jun 18.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA; Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, USA; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, USA. Electronic address:

In 2015-2016, the little known Zika virus (ZIKV) caused an epidemic, in which it became recognized as a unique human pathogen associated with a range of devastating congenital abnormalities collectively categorized as congenital Zika syndrome (CZS). In adults, the virus can trigger the autoimmune disorder Guillain-Barré syndrome (GBS), characterized by ascending paralysis. In February 2016, the World Health Organization (WHO) declared ZIKV to be a Public Health Emergency of International Concern. Read More

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http://dx.doi.org/10.1016/j.coviro.2020.05.002DOI Listing

Autoinflammatory and autoimmune conditions at the crossroad of COVID-19.

J Autoimmun 2020 Jun 16:102506. Epub 2020 Jun 16.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia. Electronic address:

Coronavirus disease 2019 (COVID-19) has been categorized as evolving in overlapping phases. First, there is a viral phase that may well be asymptomatic or mild in the majority, perhaps 80% of patients. The pathophysiological mechanisms resulting in minimal disease in this initial phase are not well known. Read More

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http://dx.doi.org/10.1016/j.jaut.2020.102506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296326PMC