12,135 results match your criteria Acute Inflammatory Demyelinating Polyradiculoneuropathy


SARS-CoV-2 vaccinations reduce the prevalence of post-COVID Guillain-Barre syndrome.

Clinics (Sao Paulo) 2022 Jun 13;77:100064. Epub 2022 Jun 13.

Disciplina de Neurociência, Universidade Federal de São Paulo/Escola Paulista de Medicina (UNIFESP/EPM), São Paulo, SP, Brasil.

Guillain-Barre Syndrome (GBS) has been repeatedly reported as a neurological complication of COVID-19 (post-COVID GBS [PCG]). Whether the introduction of SARS-CoV-2 vaccines reduced the prevalence of PCG is unknown. This narrative review aimed to compare the number of published PCG cases between the second half of 2020 (no vaccination available) with those of the first half of 2021 (vaccination available). Read More

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Associations of Guillain-Barré Syndrome with Coronavirus Disease 2019 Vaccination: Disproportionality Analysis Using the World Health Organization Pharmacovigilance Database.

J Peripher Nerv Syst 2022 Jun 25. Epub 2022 Jun 25.

Department of Neurology, Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea.

Background And Aims: Vaccinations against the severe acute respiratory syndrome coronavirus 2 which causes COVID-19 have been administered worldwide. We aimed to investigate associations of COVID-19 vaccination with the occurrence of Guillain-Barré syndrome (GBS).

Methods: We explored potential safety signals regarding the development of GBS using disproportionality analyses to compare COVID-19 vaccination with all adverse drug reaction (ADR) reports and influenza vaccines reported to VigiBase. Read More

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Case Series of Guillain-Barré Syndrome After the ChAdOx1 nCoV-19 (Oxford-AstraZeneca) Vaccine.

Neurol Clin Pract 2022 Apr;12(2):149-153

Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Alberta, Canada.

Purpose Of Review: Vaccination has been associated with Guillain-Barre syndrome (GBS). Amid a global vaccination campaign to stop the spread of COVID-19, fears of GBS can contribute to vaccine hesitancy. We describe 3 cases of GBS in Calgary, Canada, presenting within 2 weeks of receiving the ChAdOx1 nCoV-19 (COVISHIELD) Oxford-AstraZeneca vaccination and review the available literature. Read More

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Possible association between Guillain-Barré syndrome and SARS-CoV-2 infection in children: A case report and literature review.

Exp Ther Med 2022 Jul 23;24(1):462. Epub 2022 May 23.

Department of Pediatrics, Chivasso Hospital, I-10034 Turin, Italy.

Neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported in adults and in children, varying from mild to more debilitant symptoms, including fatigue, headache and dizziness. A series of studies have revealed a possible association between Guillain-Barré syndrome (GBS), the most common cause of acute flaccid paralysis at all ages, and SARS-CoV-2 infection. Case reports of novel coronavirus disease 2019 (COVID-19)-associated GBS mainly include adult patients, while only a few pediatric cases have been reported. Read More

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Sports Imaging of COVID-19: A Multi-Organ System Review of Indications and Imaging Findings.

Sports Health 2022 Jun 23:19417381221106448. Epub 2022 Jun 23.

Department of Radiology, NYU Grossman School of Medicine, New York, New York.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in December 2019 in Wuhan, China. Although coronavirus disease-19 (COVID-19) affects every population group, the sports community and athletes require special consideration of the effects on cardiovascular, musculoskeletal, neurologic, and respiratory systems. A comprehensive understanding of imaging indications, findings, and features of COVID-19 supports appropriate imaging utilization and effective patient management and treatment. Read More

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Nucleic Acid Vaccine Platform for DENGUE and ZIKA Flaviviruses.

Vaccines (Basel) 2022 May 24;10(6). Epub 2022 May 24.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Dengue virus and Zika virus are mosquito-borne, single-stranded, positive-sense RNA viruses that belong to the Flaviviridae family. Both the viruses are closely related and have similarities with other flaviviruses. Dengue virus (DENV) causes a severe febrile illness with fever, joint pain, and rash leading to a life-threatening condition in severe cases. Read More

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Prognosis of Guillain-Barré Syndrome Linked to COVID-19 Vaccination.

Brain Sci 2022 May 30;12(6). Epub 2022 May 30.

National Neuroscience Institute, Duke NUS Medical School, Outram Rd, Singapore 169608, Singapore.

There have been increasing reports of Guillain-Barré syndrome (GBS), a rare but debilitating neurological disease, occurring post-COVID-19 vaccination. However, the outcomes and relationships between patient demographics and clinical outcomes of post-COVID-19 vaccination GBS remain unclear. To bridge this gap, our study investigates the outcomes and clinical factors associated with poorer GBS outcomes following COVID-19 vaccination. Read More

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Pathogenesis and Manifestations of Zika Virus-Associated Ocular Diseases.

Trop Med Infect Dis 2022 Jun 15;7(6). Epub 2022 Jun 15.

Pennsylvania College of Optometry, Salus University, Elkins Park, PA 19027, USA.

Zika virus (ZIKV) is mosquito-borne flavivirus that caused a significant public health concern in French Polynesia and South America. The two major complications that gained the most media attention during the ZIKV outbreak were Guillain-Barré syndrome (GBS) and microcephaly in newborn infants. The two modes of ZIKV transmission are the vector-borne and non-vector borne modes of transmission. Read More

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Guillain-Barré syndrome in patients with SARS-CoV-2 infection. Report of three cases.

Rev Med Chil 2021 Dec;149(12):1812-1816

Departamento de Ciencias Neurológicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

Several cases of Guillain Barre Syndrome (GBS) associated with SARS-CoV-2 have been published, most being acute inflammatory demyelinating polyradiculoneuropathy. Between April and December 2020, 1,499 cases of SARS-CoV-2 infection were admitted to Hospital del Salvador, in Santiago, Chile, serving a population of 521,920 adults. In the same period, seven cases of GBS were admitted. Read More

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December 2021

Dengue encephalitis featuring "double-doughnut" sign - A case report.

Ann Med Surg (Lond) 2022 Jun 5;78:103939. Epub 2022 Jun 5.

Department of Neurology, Tribhuvan University Institute of Medicine, Maharajgunj, 44600, Kathmandu, Nepal.

Introduction: Dengue is a common febrile illness caused by Dengue virus and spread by mosquitoes. The neurological complications like encephalopathy or encephalitis or immune-mediated neurological syndromes are uncommon though. Discrete neuroimaging findings in this setting are even rarer. Read More

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A Rare Case of COVID-19-Induced Chronic Demyelinating Polyneuropathy.

Cureus 2022 May 20;14(5):e25165. Epub 2022 May 20.

Infectious Disease, Trinity West Medical Center, Steubenville, USA.

Chronic autoimmune demyelinating polyneuropathy (CIDP) is a rare autoimmune disorder in which the body's immune system attacks the myelin sheaths. Myelin sheaths are the fatty insulation covering and protecting the nerves, and damage to these can lead to neurological symptoms like numbness, tingling, and weakness. CIDP is a chronic disease in the Guillain-Barré syndrome spectrum. Read More

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[Neurological complications and consequences of new coronavirus COVID-19 infection in elderly and old patients (literature review).]

Adv Gerontol 2022 ;35(2):231-242

Saint-Petersburg State University, 7-9 Universitetskaya emb., St. Petersburg 199034, Russian Federation, e-mail:

Based on the available publications, the article systematizes information about some forms of lesions of the central nervous system (CNS), their pathogenesis, and clinical manifestations in COVID-19. Risk factors, developmental mechanisms, diagnostic approach, age characteristics of patients with neurological complications of COVID-19 are discussed. The specific mechanisms of the neuroinvasiveness and neurovirulence of the SARS-CoV-2 virus, regardless of the age of patients and the presence of risk factors, lead to systemic damage to the endothelium of small-caliber vessels, generalized thrombovasculitis, and an increased risk of ischemic and hemorrhagic strokes. Read More

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Characterising the background incidence rates of adverse events of special interest for covid-19 vaccines in eight countries: multinational network cohort study.

BMJ 2021 06 14;373:n1435. Epub 2021 Jun 14.

Centre for Statistics in Medicine, NDORMS, University of Oxford, Oxford, UK

Objective: To quantify the background incidence rates of 15 prespecified adverse events of special interest (AESIs) associated with covid-19 vaccines.

Design: Multinational network cohort study.

Setting: Electronic health records and health claims data from eight countries: Australia, France, Germany, Japan, the Netherlands, Spain, the United Kingdom, and the United States, mapped to a common data model. Read More

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Safety evaluation of the single-dose Ad26.COV2.S vaccine among healthcare workers in the Sisonke study in South Africa: A phase 3b implementation trial.

PLoS Med 2022 Jun 21;19(6):e1004024. Epub 2022 Jun 21.

Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.

Background: Real-world evaluation of the safety profile of vaccines after licensure is crucial to accurately characterise safety beyond clinical trials, support continued use, and thereby improve public confidence. The Sisonke study aimed to assess the safety and effectiveness of the Janssen Ad26.COV2. Read More

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Neurological Manifestations of Scrub Typhus.

Curr Neurol Neurosci Rep 2022 Jun 21. Epub 2022 Jun 21.

Department of Neurology, Vivekananda Institute of Medical Science, Kolkata, India.

Purpose Of Review: The occurrence of cases of scrub typhus is on the rise in South Asian and Southeast Asian countries. The present review discusses neurological complications following scrub typhus to appraise clinicians practicing in endemic regions about considering this treatable disease in the differential diagnosis of acute febrile illnesses, especially when accompanied with clinical neurological features.

Recent Findings: While the association of aseptic meningitis, encephalitis, and meningoencephalitis with scrub typhus is well known, more recently described neurological syndromes associated with scrub typhus include acute disseminated encephalomyelitis, various cranial nerve palsies, cerebellitis, cerebrovascular diseases including cerebral venous sinus thrombosis, transverse myelitis, longitudinally extensive transverse myelitis, Guillain-Barré syndrome, opsoclonus-myoclonus syndrome, parkinsonism, and many more. Read More

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Vaccines based on the replication-deficient simian adenoviral vector ChAdOx1: Standardized template with key considerations for a risk/benefit assessment.

Vaccine 2022 Jun 14. Epub 2022 Jun 14.

Brighton Collaboration, a program of the Task Force for Global Health, Decatur, GA, USA.

Replication-deficient adenoviral vectors have been under investigation as a platform technology for vaccine development for several years and have recently been successfully deployed as an effective COVID-19 counter measure. A replication-deficient adenoviral vector based on the simian adenovirus type Y25 and named ChAdOx1 has been evaluated in several clinical trials since 2012. The Brighton Collaboration Benefit-Risk Assessment of VAccines by TechnolOgy (BRAVATO) was formed to evaluate the safety and other key features of new platform technology vaccines. Read More

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Safety of COVID-19 vaccination and acute neurological events: A self-controlled case series in England using the OpenSAFELY platform.

Vaccine 2022 Jun 7. Epub 2022 Jun 7.

OpenSAFELY Collaborative, UK; TPP, TPP House, 129 Low Lane, Horsforth, Leeds LS18 5PX, UK.

Introduction: We investigated the potential association of COVID-19 vaccination with three acute neurological events: Guillain-Barré syndrome (GBS), transverse myelitis and Bell's palsy.

Methods: With the approval of NHS England we analysed primary care data from >17 million patients in England linked to emergency care, hospital admission and mortality records in the OpenSAFELY platform. Separately for each vaccine brand, we used a self-controlled case series design to estimate the incidence rate ratio for each outcome in the period following vaccination (4-42 days for GBS, 4-28 days for transverse myelitis and Bell's palsy) compared to a within-person baseline, using conditional Poisson regression. Read More

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A Rare Case of Guillain-Barré Syndrome Associated With SARS-CoV-2 Infection Requiring Mechanical Ventilation.

Cureus 2022 Jun 10;14(6):e25810. Epub 2022 Jun 10.

Internal Medicine, Conemaugh Memorial Medical Center, Johnstown, USA.

Coronavirus disease 2019 (COVID-19) has become a worldwide pandemic since the first case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was identified in December 2019. Numerous neurological consequences have been reported with COVID-19 infection and its approved vaccines. However, Guillain-Barré syndrome (GBS) is a rare neurological complication associated with COVID-19 infection. Read More

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Acupuncture Treatment of Guillain-Barré Syndrome After Using Immune Checkpoint Inhibitors: A Case Report.

Front Neurol 2022 2;13:908282. Epub 2022 Jun 2.

The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Guillain-Barré syndrome(GBS) is an autoimmune-mediated peripheral neuropathy. Immune checkpoint inhibitors (ICIs) are the standard treatment for cancer and may lead to immune-related adverse events (irAEs) such as GBS. Corticosteroids, plasma exchange (PE), and intravenous immunoglobulin (IVIG) are currently accepted treatments for ICI-induced GBS. Read More

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Lesion Localization and Prognosis Using Electrodiagnostic Studies in Facial Diplegia: A Rare Variant of Guillain-Barre Syndrome.

Cureus 2022 May 16;14(5):e25047. Epub 2022 May 16.

Neurology, Aga Khan Health Service, Karachi, PAK.

Background The etiology of facial nerve palsy is diverse and includes herpes zoster virus, Guillain-Barre syndrome (GBS), otitis media, Lyme disease, sarcoidosis, human immunodeficiency virus, etc. The lower motor neuron type facial nerve palsy is usually caused by an ipsilateral facial nerve lesion; however, it may be caused by a central lesion of the facial nerve nucleus and tract in the pons. Facial diplegia is an extremely rare condition that occurs in approximately 0. Read More

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Encephaloradiculoneuropathy: A Rare Manifestation of COVID-19 Infection.

Indian J Crit Care Med 2022 May;26(5):646-648

Department of Neurology, TN Medical College, BYL Nair Hospital, Mumbai, Maharashtra, India.

Neurological complications are being recognized as important outcomes of the coronavirus disease-2019 (COVID-19) pandemic. We report a rare case of both the central nervous system (CNS) and peripheral nervous system (PNS) involvement, encephalitis with polyradiculoneuropathy in a single patient of COVID infection.

How To Cite This Article: Chakor RT, Barvalia PP, Nadaf S, Manjunath V. Read More

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Post-CMV Guillain-Barré Syndrome with Anti-GM2 Antibodies: Two Cases and a Review of the Literature.

Neuropediatrics 2022 Jun 18. Epub 2022 Jun 18.

Unité de Neuropédiatrie, Hôpital des enfants, CHU Toulouse, Toulouse, France.

Introduction:  Guillain-Barré syndrome (GBS) is an acute post-infectious inflammatory polyneuropathy of ubiquitous distribution. Cytomegalovirus (CMV) is the virus that is most frequently involved. All ages are affected but rare pediatric cases seem to show some distinctive features in terms of specificity and severity. Read More

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Reply: Neurological disease in pregnant females with COVID-19 may not only be attributable to SARS-CoV-2.

Acta Neurol Scand 2022 Jun 17. Epub 2022 Jun 17.

Department of Neuropsychiatry, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, Brazil.

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Screening Power of Short Tau Inversion Recovery Muscle Magnetic Resonance Imaging in Critical Illness Myoneuropathy and Guillain-Barre Syndrome in the Intensive Care Unit.

Indian J Crit Care Med 2022 Feb;26(2):204-209

Department of Neurology, Division of Neurocritical Care, Aster Medcity, Kochi, Kerala, India.

Introduction: Critical illness myoneuropathy (CIMN) or intensive care unit (ICU)-acquired weakness (AW) is a common cause of weakness in ICU patients. Guillain-Barre syndrome (GBS) is also a common cause of acute neurological weakness in the ICU. It is diagnosed by clinical features, nerve conduction studies (NCS), and muscle/nerve biopsies. Read More

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February 2022

Old age and multiple comorbidity are associated with delayed diagnosis of Guillain-Barre syndrome.

Sci Rep 2022 Jun 15;12(1):9913. Epub 2022 Jun 15.

Department of Neurology, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.

To assess whether older age and presence of comorbidities were associated with a delayed diagnosis of Guillain-Barré syndrome (GBS). The medical records of 140 patients diagnosed with GBS at Severance Hospital from March 2011 to December 2020 were retrospectively reviewed. Comorbidity profiles were assessed using the Charlson comorbidity index (CCI). Read More

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Paraneoplastic Demyelinating Inflammatory Neuropathy Revealing Metastatic Seminoma: A Case Report.

Chemotherapy 2022 Jun 14:1-5. Epub 2022 Jun 14.

Medical Oncology Department, Centre Oscar Lambret, Lille, France.

Paraneoplastic neurological syndrome (PNS) is uncommon and not well known. PNS can reveal cancer, but its role in seminomas has not been described explicitly. We report the case of a 36-year-old man with unremarkable medical history and no comorbidities who was diagnosed with a retroperitoneal metastatic seminoma. Read More

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Electrodiagnostic subtyping in Guillain-Barré syndrome: Use of criteria in practice based on a survey study in IGOS.

J Peripher Nerv Syst 2022 Jun 14. Epub 2022 Jun 14.

Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Electrodiagnostic (EDx) studies are helpful in diagnosing and subtyping of Guillain-Barré syndrome (GBS). Published criteria for differentiation into GBS subtypes focus on cutoff values, but other items receive less attention, although they may influence EDx subtyping: (a) extensiveness of EDx testing, (b) nerve-specific considerations, (c) distal compound muscle action potential (CMAP)-amplitude requirements, (d) criteria for conduction block and temporal dispersion. The aims of this study were to investigate how these aspects were approached by neuromuscular EDx experts in practice and how this was done in previously published EDx criteria for GBS. Read More

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Neurological Complications of Malaria.

Curr Neurol Neurosci Rep 2022 Jun 14. Epub 2022 Jun 14.

Department of Neurology, Vivekananda Institute of Medical Science, Kolkata, India.

Purpose Of Review: To discuss the neurological complications and pathophysiology of organ damage following malaria infection.

Recent Findings: The principal advancement made in malaria research has been a better understanding of the pathogenesis of cerebral malaria (CM), the most dreaded neurological complication generally caused by Plasmodium falciparum infection. However, no definitive treatment has yet been evolved other than the use of antimalarial drugs and supportive care. Read More

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Mining therapeutic targets from the antibiotic-resistant Campylobacter coli and virtual screening of natural product inhibitors against its riboflavin synthase.

Mol Divers 2022 Jun 14. Epub 2022 Jun 14.

Jamil-ur-Rahman Center for Genome Research, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.

Campylobacter coli resides in the intestine of several commonly consumed animals, as well as water and soil. It leads to campylobacteriosis when humans eat raw/undercooked meat or come into contact with infected animals. A common manifestation of the infection is fever, nausea, headache, and diarrhea. Read More

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Olfactory outcomes in Zika virus-associated Guillain-Barré syndrome.

Eur J Neurol 2022 Jun 14. Epub 2022 Jun 14.

Institut Pasteur, Université Paris Cité, Perception and Memory Unit, Centre National de la Recherche Scientifique, Unité Mixte de Recherche, Paris, France.

Background: Zika Virus (ZIKV) infection has been associated with Guillain-Barré Syndrome (GBS). Yet, little is known about the consequence of ZIKV infection on olfaction in humans.

Methods: Just right before the COVID-19 outbreak, we prospectively investigated the olfactory capacities of 19 patients with ZIKV-associated GBS from the French West Indies and compared them to 9 controls from the same population, with a GBS of similar severity but independent of Zika infection. Read More

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