9,803 results match your criteria Acute Inflammatory Demyelinating Polyradiculoneuropathy


Rare variant of Guillain-Barré syndrome after chikungunya viral fever.

BMJ Case Rep 2019 Apr 23;12(4). Epub 2019 Apr 23.

Neurology, Aga Khan University Hospital, Karachi, Pakistan.

Chikungunya (CHIK) viral fever is a self-limiting illness that presents with severe debilitating arthralgia, myalgia, fever and rash. Neurological complications are rare. We present a case of a 36-year-old woman who presented with acute onset progressive difficulty swallowing and left arm weakness. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-228845DOI Listing

Knowledge and perceptions of Zika virus transmission in the community of Puerto Plata, Dominican Republic.

BMC Infect Dis 2019 Apr 24;19(1):339. Epub 2019 Apr 24.

Department of Epidemiology and Biostatistics, Indiana University School of Public Health - Bloomington, 1025 E. 7th Street, Room C03, Bloomington, IN, 47405, USA.

Background: Zika virus is associated with increased cases of both microcephaly and Guillain-Barré syndrome. Community knowledge, perceptions and practices to prevent infection with the Zika virus are not well understood, particularly among high risk populations living in resource-poor and Zika-endemic areas. Our objective was to assess knowledge of symptoms, health effects and prevention practices associated with Zika virus in rural communities on the northern coast of the Dominican Republic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-019-3952-0DOI Listing

Discovery and Computational Analyses of Novel Small Molecule Zika Virus Inhibitors.

Molecules 2019 Apr 13;24(8). Epub 2019 Apr 13.

Department of Medicine, Division of Infectious Diseases, School of Medicine, University of California San Diego, La Jolla, CA 92037, USA.

Zika virus (ZIKV), one of the flaviviruses, has attracted worldwide attention since its large epidemics around Brazil. Association of ZIKV infection with microcephaly and neurological problems such as Guillain-Barré syndrome has prompted intensive pathological investigations. However, there is still a long way to go on the discovery of effective anti-ZIKV therapeutics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules24081465DOI Listing

Serologic Tools and Strategies to Support Intervention Trials to Combat Zika Virus Infection and Disease.

Trop Med Infect Dis 2019 Apr 19;4(2). Epub 2019 Apr 19.

Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Decatur, GA 30030, USA.

Zika virus is an emerging mosquito-borne flavivirus that recently caused a large epidemic in Latin America characterized by novel disease phenotypes, including Guillain-Barré syndrome, sexual transmission, and congenital anomalies, such as microcephaly. This epidemic, which was declared an international public health emergency by the World Health Organization, has highlighted shortcomings in our current understanding of, and preparation for, emerging infectious diseases in general, as well as challenges that are specific to Zika virus infection. Vaccine development for Zika virus has been a high priority of the public health response, and several candidates have shown promise in pre-clinical and early phase clinical trials. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/tropicalmed4020068DOI Listing

Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells.

Viruses 2019 Apr 20;11(4). Epub 2019 Apr 20.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

Zika virus (ZIKV), an emerging flavivirus that causes neurodevelopmental impairment to fetuses and has been linked to Guillain-Barré syndrome continues to threaten global health due to the absence of targeted prophylaxis or treatment. Nucleoside analogues are good examples of efficient anti-viral inhibitors, and prodrug strategies using phosphate masking groups (ProTides) have been employed to improve the bioavailability of ribonucleoside analogues. Here, we synthesized and tested a small library of 13 ProTides against ZIKV in human neural stem cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v11040365DOI Listing

Rivaroxaban: A Possible Cause of Guillain-Barre Syndrome.

Ann Indian Acad Neurol 2019 Apr-Jun;22(2):242-244

Department of Neurology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/aian.AIAN_331_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472232PMC

Pharyngeal-Cervical-Brachial Variant of Guillain-Barré Syndrome Following Dengue Infection: A Rare Syndrome with Rare Association.

Ann Indian Acad Neurol 2019 Apr-Jun;22(2):240-241

Department of Medicine, Teerthanker Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, India.

Pharyngeal-cervical-brachial (PCB) variant is a rare localized variant of Guillain-Barré syndrome that presents with a rapidly progressive oropharyngeal and cervicopharyngeal weakness associated with areflexia in the upper limb. Here, we are describing a case of a 20-year-old female who had a preceding history of fever with thrombocytopenia that was found to be dengue ELISA positive. This was followed by rapidly progressive weakness of cervical, bulbar, and bilateral facial muscles along with areflexia of upper limb. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/aian.AIAN_253_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472218PMC

Long-Segment Myelitis, Meningoencephalitis, and Axonal Polyneuropathy in a Case of Scrub Typhus.

Ann Indian Acad Neurol 2019 Apr-Jun;22(2):237-240

Department of Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.

Scrub typhus, a mite-borne zoonotic disease, is endemic in several parts of India. It may cause multisystemic disease involving lungs, heart, spleen, liver, hematological system, and nervous system. Neurological involvement may include meningoencephalitis, cerebellitis, cranial nerve palsies, plexopathy, transverse myelitis, muscle dysfunction, neuroleptic malignant syndrome, parkinsonian syndrome, and Guillain-Barre syndrome. Read More

View Article

Download full-text PDF

Source
http://www.annalsofian.org/preprintarticle.asp?id=243807
Publisher Site
http://dx.doi.org/10.4103/aian.AIAN_66_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472236PMC
April 2019
1 Read

The utility of Guillain-Barré syndrome prognostic models in Malaysian patients.

J Peripher Nerv Syst 2019 Apr 19. Epub 2019 Apr 19.

Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Guillain-Barré syndrome (GBS) is an acute immune-mediated neuropathy that has variable disease course and outcome. The Erasmus GBS Outcome Score (EGOS), modified EGOS (mEGOS) and Erasmus GBS Respiratory Insufficiency Score (EGRIS) are prognostic models designed to predict the functional outcome of GBS patients at 6 months (EGOS and mEGOS) and the need for mechanical ventilation within a week of admission (EGRIS). The models were primarily developed in the Dutch GBS population and thus, the usefulness of these models in other GBS cohorts is less clear. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/jns.12320
Publisher Site
http://dx.doi.org/10.1111/jns.12320DOI Listing
April 2019
1 Read

Natural Diterpenoid Oridonin Ameliorates Experimental Autoimmune Neuritis by Promoting Anti-inflammatory Macrophages Through Blocking Notch Pathway.

Front Neurosci 2019 2;13:272. Epub 2019 Apr 2.

Department of Pathology, Nanjing Medical University, Nanjing, China.

The diterpenoid compound, Oridonin, extracted from the Chinese herb, , possesses multiple biological activities and properties. Oridonin exhibited efficient anti-inflammatory activity by inducing a switch in macrophage polarization to the anti-inflammatory phenotype through inhibition of the Notch pathway in our study; therefore, its potential therapeutic effects were further investigated in the animal model of human Guillain-Barré syndrome (GBS) and other polyneuropathies - experimental autoimmune neuritis (EAN). Either preventive or therapeutic treatments with Oridonin greatly attenuated disease peak severity, suppressed paraparesis, shortened disease duration, and even delayed EAN onset. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnins.2019.00272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454011PMC

Tonic pupils: an unusual autonomic involvement in chronic inflammatory demyelinating polyneuropathy (CIDP).

Neurol Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo, 650, São Paulo, SP, 04039-002, Brazil.

Background: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neuropathy which affects mainly large myelinated axons and has a typically mild autonomic dysfunction mainly from postganglionic nerve fiber involvement.

Case Report: We report here an acute onset CIDP initially diagnosed as Guillain-Barré syndrome (GBS), unresponsive to treatment with intravenous immunoglobulin (IVIg), which later responded to plasmapheresis and corticoids. The patient had a markedly distal demyelination, prominent cranial nerve involvement and, interestingly, bilateral fixed dilated pupils. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10072-019-03890-8DOI Listing
April 2019
1 Read

Development of MRC Centre MRI calf muscle fat fraction protocol as a sensitive outcome measure in Hereditary Sensory Neuropathy Type 1.

J Neurol Neurosurg Psychiatry 2019 Apr 17. Epub 2019 Apr 17.

MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK

Objectives: Hereditary sensory neuropathy type 1 (HSN1) is a rare, slowly progressive neuropathy causing profound sensory deficits and often severe motor loss. L-serine supplementation is a possible candidate therapy but the lack of responsive outcome measures is a barrier for undertaking clinical trials in HSN1. We performed a 12-month natural history study to characterise the phenotype of HSN1 and to identify responsive outcome measures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2018-320198DOI Listing
April 2019
1 Read

Dysautonomia and hyponatraemia as harbingers of Guillain-Barre syndrome.

BMJ Case Rep 2019 Apr 15;12(4). Epub 2019 Apr 15.

Department of Critical Care, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India.

A 56-year-old woman with a medical history of hypertension presented to our hospital with back pain, abdominal pain, vomiting and elevated blood pressure. The laboratory parameters including evaluation for secondary hypertension were within normal ranges at the time of presentation. During her hospitalisation, fluctuations in her blood pressure and pulse were observed which were attributed to autonomic disturbances, the cause of which was unknown. Read More

View Article

Download full-text PDF

Source
http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22692
Publisher Site
http://dx.doi.org/10.1136/bcr-2018-226925DOI Listing
April 2019
3 Reads

Acute flaccid paralysis in North East Delta, Egypt: A retrospective analysis of prospectively collected surveillance data.

J Infect Public Health 2019 Apr 13. Epub 2019 Apr 13.

Ministry of Health, Egypt. Electronic address:

Background: Effective acute flaccid paralysis (AFP) surveillance is crucial in countries approaching the final phase of polio eradication. Thus this study was conducted to highlight the epidemiological pattern of AFP as a surveillance tool for polio in Egypt.

Methods: A record-based descriptive study was conducted to include all AFP cases (599) reported in the last 9 years starting from January 2009 to December 2017 in Dakahlia, North East of Delta, Egypt. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18760341193012
Publisher Site
http://dx.doi.org/10.1016/j.jiph.2019.03.016DOI Listing
April 2019
2 Reads

Screening pipeline for Flavivirus based Inhibitors for Zika Virus NS1.

IEEE/ACM Trans Comput Biol Bioinform 2019 Apr 15. Epub 2019 Apr 15.

In-silico pipeline is applied for identifying and designing novel inhibitors against ZIKV NS1 protein. Comparative molecular docking studies are performed to explore the binding of structurally diverse compounds to ZIKV NS1 by AutoDock/Vina and GOLD. The Zika virus (ZIKV) is a flavivirus, responsible for life-threatening infections and transmitted by Aedes mosquitoes in other organisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1109/TCBB.2019.2911081DOI Listing
April 2019
2 Reads

Time Course of Axon and Myelin Degeneration in Peripheral Nerves in Experimental Autoimmune Neuritis Rats.

Toxicol Pathol 2019 Apr 15:192623319838993. Epub 2019 Apr 15.

2 Clinical Research Department, Toray Industries, Inc., Tokyo, Japan.

Experimental autoimmune neuritis (EAN) is an animal model for Guillain-Barré syndrome (GBS), which results in neurological symptoms and histopathological changes in peripheral nerves. In this model, the correlation between the progression of the disease and the histopathological changes is not clear. To further examine histopathological changes in peripheral nerves in EAN rats, sciatic nerves were sampled at onset (day 10), peak (day 16), and recovery (days 22 and 25) of neurological symptoms in P2(57-81)-peptide-administered rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0192623319838993DOI Listing
April 2019
1 Read

A case report of Guillain Barré syndrome revealing underlying infective endocarditis due to Cardiobacterium hominis.

Medicine (Baltimore) 2019 Apr;98(15):e15014

Service de Cardiologie Médicale, CHU de Nancy Hôpitaux de Brabois, Vandœuvre-lès-Nancy, France.

Rationale: Guillain-Barré syndrome (GBS) is an acute inflammatory polyradiculoneuropathy presumed to result from an infection-triggered autoimmune reaction.

Patient Concerns: This paper describes a 53-year-old man admitted to hospital for deterioration of his general condition.

Diagnosis: He developed GBS, confirmed by lumbar puncture and electromyogram, which recovered after intravenous immunoglobulins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015014DOI Listing
April 2019
1 Read

Role of IV Immunoglobulin in Indian Children With Guillain-Barré Syndrome.

Pediatr Crit Care Med 2019 Apr 5. Epub 2019 Apr 5.

All authors: Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Objectives: To evaluate the outcome of Indian children with Guillain-Barré syndrome who received IV immunoglobulin compared with those who did not receive any specific therapy.

Design: Single center, prospective cross-sectional study.

Setting: Tertiary care neurology teaching hospital. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00130478-900000000-9827
Publisher Site
http://dx.doi.org/10.1097/PCC.0000000000001935DOI Listing
April 2019
2 Reads

Immune Cell Profiling of the Cerebrospinal Fluid Provides Pathogenetic Insights Into Inflammatory Neuropathies.

Front Immunol 2019 21;10:515. Epub 2019 Mar 21.

Department of Neurology, Institute of Translational Neurology, University of Münster, Münster, Germany.

Utilize immune cell profiles in the cerebrospinal fluid (CSF) to advance the understanding and potentially support the diagnosis of inflammatory neuropathies. We analyzed CSF cell flow cytometry data of patients with definite Guillain-Barré syndrome (GBS, = 26) and chronic inflammatory demyelinating polyneuropathy (CIDP, = 32) based on established diagnostic criteria in comparison to controls with relapsing-remitting multiple sclerosis (RRMS, = 49) and idiopathic intracranial hypertension (IIH, = 63). Flow cytometry revealed disease-specific changes of CSF cell composition with a significant increase of NKT cells and CD8+ T cells in CIDP, NK cells in GBS, and B cells and plasma cells in MS in comparison to IIH controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.00515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448021PMC
March 2019
1 Read

Zika Virus Infection Disrupts Astrocytic Proteins Involved in Synapse Control and Axon Guidance.

Front Microbiol 2019 26;10:596. Epub 2019 Mar 26.

Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.

The first human Zika virus (ZIKV) outbreak was reported in Micronesia in 2007, followed by one in Brazil in 2015. Recent studies have reported cases in Europe, Oceania and Latin America. In 2016, ZIKV transmission was also reported in the US and the World Health Organization declared it a Public Health Emergency of International Concern. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2019.00596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448030PMC
March 2019
1 Read

Mechanism of Action of Methotrexate Against Zika Virus.

Viruses 2019 Apr 10;11(4). Epub 2019 Apr 10.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

Zika virus (ZIKV), which is associated with microcephaly in infants and Guillain-Barré syndrome, reemerged as a serious public health threat in Latin America in recent years. Previous high-throughput screening (HTS) campaigns have revealed several potential hit molecules against ZIKV, including methotrexate (MTX), which is clinically used as an anti-cancer chemotherapy and anti-rheumatoid agent. We studied the mechanism of action of MTX against ZIKV in relation to its inhibition of dihydrofolate reductase (DHFR) in vitro using Vero and human neural stem cells (hNSCs). Read More

View Article

Download full-text PDF

Source
https://www.mdpi.com/1999-4915/11/4/338
Publisher Site
http://dx.doi.org/10.3390/v11040338DOI Listing
April 2019
2 Reads

Zika Virus: Relevance to the State of Hawai'i.

Hawaii J Med Public Health 2019 Apr;78(4):123-127

Saint Francis High School, Mountain View, CA (WJL).

Zika virus (ZIKV) is spread among human populations primarily through the bite of mosquitoes. While most ZIKV infections are asymptomatic or cause self-limited symptoms, the major concerns are its association with Guillain-Barré Syndrome and fetal microcephaly together with other birth defects, known as congenital Zika syndrome (CZS). This article reviews the confirmed Zika cases in the continental United States (U. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452016PMC
April 2019
1 Read

[A case of Crohn's disease complicated by Guillain-Barrè syndrome during ustekinumab therapy].

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(4):324-329

Coloproctology Center Matsushima Hospital.

We herein report a case involving a 23-year-old male patient with active Crohn's disease complicated by Guillain-Barrè syndrome during ustekinumab therapy. At age 11, the patient developed an anal fistula and was found to have multiple aphthae on the rectosigmoid colon, for which he was diagnosed with Crohn's disease. At age 12, he underwent gastrojejunal anastomosis for pyrolic stenosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11405/nisshoshi.116.324DOI Listing
January 2019
1 Read

Guillain-Barré syndrome after viral hepatitis A.

Med Clin (Barc) 2019 Apr 7. Epub 2019 Apr 7.

Unidad de Gestión Clínica de Neurología y Neurofisiología, Hospital Universitario Virgen Macarena, Sevilla, España.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.medcli.2019.02.005DOI Listing
April 2019
1 Read

Early predictors of functional disability in Guillain-Barré Syndrome.

Authors:
Abdulkadir Tunç

Acta Neurol Belg 2019 Apr 8. Epub 2019 Apr 8.

Clinic of Neurology, Sakarya Training and Research Hospital, Sakarya University, Sakarya, Turkey.

This study investigated the predictors of prognosis at admission and after the first month in Guillain-Barré syndrome (GBS) patients. This retrospective study used the electronic records of 81 GBS patients. Age, gender, previous GBS history, antecedent febrile illness and presence of cranial nerve dysfunction were recorded. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13760-019-01133-3DOI Listing
April 2019
1 Read

False-positive acetylcholine receptor antibody results in patients without myasthenia gravis.

J Neuroimmunol 2019 Apr 3;332:69-72. Epub 2019 Apr 3.

Nuffield Department of Clinical Neurosciences,West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

Acetylcholine receptor antibodies are very specific for myasthenia. During a large prospective cohort study of myasthenia, we encountered five patients, positive for acetylcholine receptor (AChR) antibodies by radioimmunoprecipitation assay (RIA), whose clinical course revealed diagnoses other than myasthenia. Two patients had transiently raised AChR antibodies associated with Guillain-Barré syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jneuroim.2019.04.001DOI Listing
April 2019
2 Reads

Does intravenous immunoglobulin therapy in Guillain-Barré syndrome patients interfere with serological Zika detection?

Autoimmun Rev 2019 Apr 5. Epub 2019 Apr 5.

Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Equipe - Immunopathologie et Immunointervention Thérapeutique, Sorbonne Université, Paris F-75006, France; Université Paris Descartes, Sorbonne Paris Cité, Paris F-75006, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2019.01.004DOI Listing
April 2019
3 Reads

Antiviral activity of pinocembrin against Zika virus replication.

Antiviral Res 2019 Apr 5;167:13-24. Epub 2019 Apr 5.

Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore. Electronic address:

Zika virus (ZIKV) is a mosquito-borne virus that has garnered a lot of attention in recent years, due to the explosive epidemic from 2014 to 2016. Since its introduction in the Americas in late 2014, ZIKV has spread at an unprecedented rate and scale throughout the world and infected millions of people. Its infection has also been associated with severe neurological disorders like Guillain-Barré syndrome and microcephaly in fetuses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.antiviral.2019.04.003DOI Listing
April 2019
2 Reads

Genetic and biochemical characterizations of Zika virus NS2A protein.

Emerg Microbes Infect 2019 ;8(1):585-602

c Department of Biochemistry & Molecular Biology , University of Texas Medical Branch , Galveston , TX , USA.

Zika virus (ZIKV) can cause devastating congenital Zika syndromes in pregnant women and Guillain-Barre syndrome in adults. Understanding the molecular mechanism of ZIKV replication is essential for antiviral and vaccine development. Here we report the structural and functional characterization of ZIKV NS2A protein. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/22221751.2019.1598291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455252PMC
January 2019
1 Read

Antecedent infections in Fisher syndrome: sources of variation in clinical characteristics.

J Neurol 2019 Apr 6. Epub 2019 Apr 6.

Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Minami-kogushi 1-1-1, Ube, Yamaguchi, 755-8505, Japan.

The clinical features of Guillain-Barré syndrome (GBS) are highly variable, according to the type of antecedent infection. Although a major GBS phenotype, Fisher syndrome (FS), has been shown to be preceded by infections similar to those preceding GBS, whether or not the clinical features in FS also vary according to antecedent infection remains unclarified. Frequent antecedent infections among this study of 70 FS patients included Haemophilus influenzae [n = 15 (21%)], Campylobacter jejuni [n = 10 (14%)], and cytomegalovirus (CMV) [n = 6 (8. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-019-09308-xDOI Listing
April 2019
2 Reads

Severe bornavirus-encephalitis presenting as Guillain-Barré-syndrome.

Acta Neuropathol 2019 Apr 5. Epub 2019 Apr 5.

Institute of Virology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Schlossgarten 4, 91054, Erlangen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-019-02005-zDOI Listing

Detecting Vertical Zika Transmission: Emerging Diagnostic Approaches for an Emerged Flavivirus.

ACS Infect Dis 2019 Apr 17. Epub 2019 Apr 17.

Department of Medicine, Division of Infectious Diseases , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.

Zika virus (Zika) was recently responsible for a massive epidemic that spread throughout Latin America and beyond. Though Zika is typically asymptomatic or self-limiting, the sheer numbers of Zika infections led to the identification of unexpected phenotypes including sexual transmission, Guillain-Barré syndrome, and teratogenicity. Thousands of infants in South, Central, and North America have now been born with microcephaly or one of a number of fetal anomalies constituting the congenital Zika syndrome (CZS). Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acsinfecdis.9b00003
Publisher Site
http://dx.doi.org/10.1021/acsinfecdis.9b00003DOI Listing
April 2019
8 Reads

Brain Infection by Hepatitis E Virus Probably via Damage of the Blood-Brain Barrier Due to Alterations of Tight Junction Proteins.

Front Cell Infect Microbiol 2019 19;9:52. Epub 2019 Mar 19.

Laboratory of Animal Pathology and Public Health, Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China.

Extrahepatic injury, particularly neurologic dysfunctions such as Guillain-Barré syndrome, neurologic amyotrophy, and encephalitis/meningoencephalitis/myositis were associated with HEV infection, which was supported by both clinical and laboratory studies. Thus, it is crucial to figure out how the virus invades into the central nervous system (CNS). In this study, CNS lesions were determined in rabbits and Mongolian gerbils inoculated with genotype 4 HEV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcimb.2019.00052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436201PMC
March 2019
1 Read

Envelope protein glycosylation mediates Zika virus pathogenesis.

J Virol 2019 Apr 3. Epub 2019 Apr 3.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Zika virus (ZIKV) is an emerging mosquito-borne flavivirus. Recent ZIKV outbreaks have produced serious human disease, including neurodevelopmental malformations (congenital Zika syndrome) and Guillain-Barré syndrome. These outcomes were not associated with ZIKV infection prior to 2013, raising the possibility that viral genetic changes could contribute to new clinical manifestations. Read More

View Article

Download full-text PDF

Source
http://jvi.asm.org/lookup/doi/10.1128/JVI.00113-19
Publisher Site
http://dx.doi.org/10.1128/JVI.00113-19DOI Listing
April 2019
4 Reads

Peripheral Demyelinating Diseases: From Biology to Translational Medicine.

Front Neurol 2019 19;10:87. Epub 2019 Mar 19.

Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Demyelinating diseases represent a spectrum of disorders that impose significant burden on global economy and society. Generally, the prognosis of these diseases is poor and there is no available cure. In recent decades, research has shed some light on the biology and physiology of Schwann cells and its neuroprotective effects in the peripheral nervous system (PNS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2019.00087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433847PMC
March 2019
3 Reads

Antibodies Elicited by an NS1-Based Vaccine Protect Mice against Zika Virus.

MBio 2019 04 2;10(2). Epub 2019 Apr 2.

Infectious Diseases, The J. Craig Venter Institute, La Jolla, California, USA

Zika virus is a mosquito-borne flavivirus which can cause severe disease in humans, including microcephaly and other congenital malformations in newborns and Guillain-Barré syndrome in adults. There are currently no approved prophylactics or therapeutics for Zika virus; the development of a safe and effective vaccine is an urgent priority. Preclinical studies suggest that the envelope glycoprotein can elicit potently neutralizing antibodies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mBio.02861-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445944PMC
April 2019
3 Reads

Rescue treatment in patients with poorly responsive Guillain-Barre syndrome.

SAGE Open Med 2019 25;7:2050312119840195. Epub 2019 Mar 25.

University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, OH, USA.

Objectives: To evaluate the effectiveness of rescue treatment (intravenous immunoglobulin or plasma exchange) in patients with Guillain-Barre syndrome who did not respond or deteriorated after the initial management with intravenous immunoglobulin.

Methods: We performed a retrospective review of the medical records of patients who responded poorly or did not respond to intravenous immunoglobulin treatment. The disability parameters of those who received second-line treatment with intravenous immunoglobulin or plasma exchange (20 patients) were compared with those who did not receive second-line treatment (19 patients). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050312119840195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434439PMC
March 2019
2 Reads

Benign Acute Childhood Myositis: A Benign Disease that Mimics More Severe Neuromuscular Disorder.

J Pediatr Neurosci 2018 Oct-Dec;13(4):404-409

Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Context: Proximal lower limb weakness presenting acutely with or without preceding fever is a strong mimic of Guillain-Barré syndrome (GBS). Benign acute childhood myositis (BACM) forms an important differential diagnosis in such cases.

Aim: To characterize the clinical and laboratory findings of patients with BACM for better understanding of the disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/JPN.JPN_116_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413614PMC
April 2019
8 Reads

Froin's Syndrome Mimicking Guillain-Barre Syndrome in a Patient with Spinal Epidural Abscess.

Asian J Neurosurg 2019 Jan-Mar;14(1):338-339

Department of Radiology, Hospital General Dr. Manuel Gea González, National Autonomous University of Mexico, Ciudad de Mexico, Mexico, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ajns.AJNS_11_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417328PMC
April 2019
6 Reads

A rare mimic of acute stroke: rapidly progressing Miller-Fisher Syndrome to acute motor and sensory axonal neuropathy variant of Guillain-Barre Syndrome.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Department of Neurosciences, University of the Philippines Manila College of Medicine and Philippine General Hospital, Manila, Philippines.

Ophthalmoplegia, ataxia and areflexia characterise the clinical triad of Miller-Fisher Syndrome (MFS). When the disease presents acutely, it can mimic posterior circulation stroke. We describe a case of an adult patient presenting with sudden dizziness, diplopia, vomiting, and loss of balance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-228220DOI Listing
March 2019
2 Reads

A Unique Case of a Pediatric Patient With Blastic Plasmacytoid Dendritic Cell Neoplasm, Guillain Barre Syndrome, and Hemophagocytic Lymphohistiocytosis.

J Pediatr Hematol Oncol 2019 Mar 29. Epub 2019 Mar 29.

Division of Pediatric Hematology/Oncology, Children's Hospital of Eastern Ontario (CHEO), Ottawa, ON, Canada.

Blastic plasmacytoid dendritic cell neoplasm is a rare hematopoietic malignancy with a poor prognosis that is seen primarily in the elderly population. We describe a pediatric patient with blastic plasmacytoid dendritic cell neoplasm who subsequently developed Guillain Barre syndrome followed by hemophagocytic lymphohistiocytosis. All 3 conditions are uncommon, particularly in the pediatric population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MPH.0000000000001464DOI Listing
March 2019
3 Reads

Development of a fluorescence-based method for the rapid determination of Zika virus polymerase activity and the screening of antiviral drugs.

Sci Rep 2019 Apr 1;9(1):5397. Epub 2019 Apr 1.

Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Madrid, 28668, Spain.

Zika virus (ZIKV) is an emerging pathogen that has been associated with large numbers of cases of severe neurologic disease, including Guillain-Barré syndrome and microcephaly. Despite its recent establishment as a serious global public health concern there are no licensed therapeutics to control this virus. Accordingly, there is an urgent need to develop methods for the high-throughput screening of antiviral agents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-41998-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444013PMC
April 2019
3 Reads

Acute Neuromuscular Respiratory Weakness Due to Acute Inflammatory Demyelinating Polyneuropathy (AIDP): A Simulation Scenario for Neurology Providers.

MedEdPORTAL 2019 Mar 1;15:10811. Epub 2019 Mar 1.

Assistant Professor of Neurology, Department of Neurology, University of Minnesota.

Introduction: Acute neuromuscular respiratory failure is a source of morbidity and mortality in neurological diseases, including acute inflammatory demyelinating polyneuropathy (AIDP), also known as Guillain-Barré syndrome. It is important for health care providers to recognize this condition and provide early ventilatory support. In this simulation, learners must assess and treat a standardized patient with acute respiratory complications related to AIDP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15766/mep_2374-8265.10811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415011PMC
March 2019
1 Read

Myalgia, Obtundity and Fever in a Patient with a Prosthesis.

Eur J Case Rep Intern Med 2019 8;6(2):001021. Epub 2019 Feb 8.

Department of Internal Medicine, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.

Objective: We describe a rare case of group G streptococcus (GGS) sepsis complicated by bacterial toxin myopathy.

Case: A 65-year-old man, with a history of infection of his shoulder prosthesis, presented with multiorgan failure and notable myalgia likely caused by toxins. The patient was treated successfully with antibiotics and prosthesis removal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2019_001021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432832PMC
February 2019
1 Read

Clinical Characteristics of Intravenous Injection of Monosialotetrahexosyl Ganglioside Sodium-Related Guillain-Barre Syndrome.

Front Neurol 2019 15;10:225. Epub 2019 Mar 15.

Department of Neurology, Neuroscience Center, First Hospital of Jilin University, Jilin University, Changchun, China.

Guillain Barre Syndrome (GBS) is an acute inflammatory immune-mediated multiple nerve root neuropathy. GBS primarily damages the spinal nerve root and peripheral nerves, but can also affect the cranial nerves and cause acute demyelination. This study analyzed the clinical features of intravenous injection of monosialotetrahexosyl ganglioside sodium-related Guillain-Barre syndrome (GRD-GBS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2019.00225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428729PMC
March 2019
4 Reads

A unicenter, prospective study of Guillain-Barré syndrome in Spain.

Acta Neurol Scand 2019 Mar 31. Epub 2019 Mar 31.

Service of Neurology, University Hospital "Marqués de Valdecilla (IDIVAL)", University of Cantabria, and "Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)", Santander, Spain.

Objective: We report a prospective study analysing clinical characteristics, subtyping and prognosis in Guillain-Barré syndrome (GBS).

Method: The study was based on consecutive GBS patients admitted between 2009 and 2017. Disability was serially assessed using the GBS disability scale. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ane.13092DOI Listing
March 2019
1 Read

Zika Virus-Associated Guillain-Barré Syndrome in a Returning US Traveler.

Infect Dis Clin Pract (Baltim Md) 2018 Nov;26(6):e80-e84

Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, New York University, School of Medicine.

Zika virus (ZIKV) infection has been associated with Guillain-Barré Syndrome (GBS). Roughly 60% of people in countries such as the U.S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IPC.0000000000000654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433380PMC
November 2018
1 Read

Guillain-Barré syndrome with unilateral peripheral facial and bulbar palsy in a child: A case report.

SAGE Open Med Case Rep 2019 21;7:2050313X19838750. Epub 2019 Mar 21.

Department of Neurology, College of Medicine, University of South Alabama, Mobile, AL, USA.

Guillain-Barré syndrome is characterized by progressive motor weakness, sensory changes, dysautonomia, and areflexia. Cranial nerve palsies are frequent in Guillain-Barré syndrome. Among cranial nerve palsies in Guillain-Barré syndrome, facial nerve palsy is the most common affecting around half of the cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050313X19838750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429638PMC
March 2019
1 Read

Guillain-Barré Syndrome and Its Variants: Clinical Course and Prognostic Factors.

Noro Psikiyatr Ars 2019 Mar 5;56(1):71-74. Epub 2018 Jul 5.

Department of Neurology, İstanbul University Cerrahpaşa Faculty of Medicine, İstanbul, Turkey.

Introduction: We aimed to analyze the frequency, clinical characteristics, medical treatment options and final functional status of Guillain-Barré syndrome (GBS) and its variants in a population from a tertiary hospital setting.

Methods: All medical records of patients with acute inflammatory polyneuropathy between the years of 1998-2013 were retrospectively screened. Demographic, clinical and laboratory information, treatment options and the rate of recovery of the patients were gathered. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5152/npa.2017.18091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427085PMC
March 2019
5 Reads

Bell's palsy and guillain-barré syndrome may be 2 ends of the same spectrum.

Muscle Nerve 2019 Mar 25. Epub 2019 Mar 25.

Department of Neurology, St John's Medical College Hospital, Bengaluru, Karnataka, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mus.26477DOI Listing
March 2019
2 Reads