1,198,540 results match your criteria Acute Hemorrhagic Edema of Infancy


The Enigmatic Protein Kinase C-eta.

Authors:
Alakananda Basu

Cancers (Basel) 2019 Feb 13;11(2). Epub 2019 Feb 13.

Department of Microbiology, Immunology & Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

Protein kinase C (PKC), a multi-gene family, plays critical roles in signal transduction and cell regulation. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and cell death. Read More

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http://dx.doi.org/10.3390/cancers11020214DOI Listing
February 2019

Toxic Effects of TiO₂ NPs on Zebrafish.

Int J Environ Res Public Health 2019 Feb 13;16(4). Epub 2019 Feb 13.

Key Laboratory of Tropical Biological Resources, Ministry of Education, Hainan University, Haikou 570228, China.

Titanium dioxide nanoparticles (TiO₂ NPs) have become a widely used nanomaterial due to the photocatalytic activity and absorption of ultraviolet light of specific wavelengths. This study investigated the toxic effects of rutile TiO₂ NPs on zebrafish by examining its embryos and adults. In the embryo acute toxicity test, exposure to 100 mg/L TiO₂ NPs didn't affect the hatching rate of zebrafish embryos, and there was no sign of deformity. Read More

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http://dx.doi.org/10.3390/ijerph16040523DOI Listing
February 2019

The Role of Osteopontin as a Diagnostic and Prognostic Biomarker in Sepsis and Septic Shock.

Cells 2019 Feb 18;8(2). Epub 2019 Feb 18.

CAAD, IRCAD, Department of Health Sciences, Università degli Studi del Piemonte Orientale, Corso Trieste 15, 28100 Novara (NO), Piedmont, Italy.

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host-response to infections. Osteopontin (OPN) is an extracellular matrix protein involved in the inflammatory response. Our aim was to evaluate the diagnostic and prognostic performance in sepsis of a single OPN determination in the Emergency Department (ED). Read More

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http://dx.doi.org/10.3390/cells8020174DOI Listing
February 2019

Chronic Hypoxia Enhances β-Oxidation-Dependent Electron Transport via Electron Transferring Flavoproteins.

Cells 2019 Feb 18;8(2). Epub 2019 Feb 18.

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.

Hypoxia poses a stress to cells and decreases mitochondrial respiration, in part by electron transport chain (ETC) complex reorganization. While metabolism under acute hypoxia is well characterized, alterations under chronic hypoxia largely remain unexplored. We followed oxygen consumption rates in THP-1 monocytes during acute (16 h) and chronic (72 h) hypoxia, compared to normoxia, to analyze the electron flows associated with glycolysis, glutamine, and fatty acid oxidation. Read More

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http://dx.doi.org/10.3390/cells8020172DOI Listing
February 2019

Loss of C/EBPδ Exacerbates Radiation-Induced Cognitive Decline in Aged Mice due to Impaired Oxidative Stress Response.

Int J Mol Sci 2019 Feb 18;20(4). Epub 2019 Feb 18.

Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Aging is characterized by increased inflammation and deterioration of the cellular stress responses such as the oxidant/antioxidant equilibrium, DNA damage repair fidelity, and telomeric attrition. All these factors contribute to the increased radiation sensitivity in the elderly as shown by epidemiological studies of the Japanese atomic bomb survivors. There is a global increase in the aging population, who may be at increased risk of exposure to ionizing radiation (IR) as part of cancer therapy or accidental exposure. Read More

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http://dx.doi.org/10.3390/ijms20040885DOI Listing
February 2019

Acute Effects of Ballistic and Non-ballistic Bench Press on Plyometric Push-up Performance.

Sports (Basel) 2019 Feb 18;7(2). Epub 2019 Feb 18.

Department of Physical Therapy and Human Movement Science, Sacred Heart University, Fairfield, CT 06825, USA.

The purpose of this study was to examine the effects of a ballistic or non-ballistic concentric-only bench press (COBP) on subsequent plyometric push-up performance. Fourteen resistance trained men completed two separate one-repetition-maximum (1RM) testing sessions followed by three randomized experimental explosive push-up sessions. These sessions combined a heavy concentric bench press with plyometric push-ups. Read More

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http://dx.doi.org/10.3390/sports7020047DOI Listing
February 2019

Toxicological Evaluation of SiO₂ Nanoparticles by Zebrafish Embryo Toxicity Test.

Int J Mol Sci 2019 Feb 18;20(4). Epub 2019 Feb 18.

Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.

As the use of nanoparticles (NPs) is increasing, the potential toxicity and behavior of NPs in living systems need to be better understood. Our goal was to evaluate the developmental toxicity and bio-distribution of two different sizes of fluorescently-labeled SiO₂ NPs, 25 and 115 nm, with neutral surface charge or with different surface functionalization, rendering them positively or negatively charged, in order to predict the effect of NPs in humans. We performed a zebrafish embryo toxicity test (ZFET) by exposing the embryos to SiO₂ NPs starting from six hours post fertilization (hpf). Read More

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http://dx.doi.org/10.3390/ijms20040882DOI Listing
February 2019

Antihyperlipidemic Effect, Identification and Isolation of the Lipophilic Components from Artemisia integrifolia.

Molecules 2019 Feb 17;24(4). Epub 2019 Feb 17.

College of Traditional Mongolian Medicine, Inner Mongolia Uaniversity for Nationalities, Tongliao 028000, China.

L (Compositae) is a medicinal and edible plant. To investigate its antihyperlipidemic effect, a crude lipophilic extract and the composing compounds were isolated and fractioned from the petroleum ether extract of aerial parts of using column chromatography on silica gel. The anti-hyperlipidemia effect was studied in a rat model of acute hyperlipidemia, which was induced by triton WR-1339. Read More

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http://dx.doi.org/10.3390/molecules24040725DOI Listing
February 2019

Iron Status of Kenyan Pregnant Women after Adjusting for Inflammation Using BRINDA Regression Analysis and Other Correction Methods.

Nutrients 2019 Feb 16;11(2). Epub 2019 Feb 16.

Danone Nutricia Research, route de la Vauve, 91120 Palaiseau, France.

Serum ferritin concentration is the preferred biomarker to assess population iron status in the absence of inflammation. Interpretation of this biomarker is complicated in populations with a high burden of infection, however, because inflammation increases serum ferritin concentration independently of iron status. We aimed to compare estimates of iron status of Kenyan pregnant women, with circulating ferritin concentrations adjusted for inflammation using newly proposed methods by the BRINDA project, or using previously proposed adjustment methods. Read More

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http://dx.doi.org/10.3390/nu11020420DOI Listing
February 2019

The TLR3 Agonist Poly Inosinic:Cytidylic Acid Significantly Augments the Therapeutic Activity of an Anti-CD7 Immunotoxin for Human T-cell Leukaemia.

Biomedicines 2019 Feb 16;7(1). Epub 2019 Feb 16.

The Simon Flavell Leukaemia Research Laboratory, Southampton General Hospital, Southampton SO16 6YD, UK.

We have previously shown that antibody-dependent cellular cytotoxicity (ADCC) cooperates with immunotoxin (IT)-mediated killing of human leukaemia cells in an severe combined immunodeficient (SCID) mouse model of human T-cell acute lymphoblastic leukaemia (SCID-HSB-2 mice), but not in an equivalent non-obese diabetic (NOD)/SCID mouse model. In these earlier studies, we reasoned that diminished ADCC due to the functional deficit in natural killer (NK) cell activity in NOD/SCID mice resulted in a failure of effective perforin/granzyme-mediated cytotoxicity necessary for the delivery of the augmentative effect. Poly-inosinic-cytidylic acid [poly (I:C)] is a synthetic dsRNA toll-like receptor 3 (TLR3) agonist that possesses a number of biological properties that includes the in vivo activation of NK cells. Read More

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http://dx.doi.org/10.3390/biomedicines7010013DOI Listing
February 2019

Relationships between Quadriceps Tendon Elasticity and Knee Flexion Angle in Young Healthy Adults.

Medicina (Kaunas) 2019 Feb 15;55(2). Epub 2019 Feb 15.

Department of Physical Therapy, Faculty of Health Sciences, Tsukuba International University, 6-8-33 Manabe, Tsuchiura, Ibaraki 300-0051, Japan.

Although tendon elasticity by elastography is useful for diagnosing tendon disorders and planning rehabilitation regimens of the tendon, there are few reports on the quadriceps tendon. Moreover, relationships between the quadriceps tendon elasticity and knee angle have not been investigated. The purpose of this study was to clarify the relationship between quadriceps tendon elasticity and knee flexion angle in young healthy adults using elastography, and to investigate the difference in elasticity by sex and leg dominance. Read More

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http://dx.doi.org/10.3390/medicina55020053DOI Listing
February 2019

Comparison of 30-Day MACE between Immediate versus Staged Complete Revascularization in Acute Myocardial Infarction with Multivessel Disease, and the Effect of Coronary Lesion Complexity.

Medicina (Kaunas) 2019 Feb 15;55(2). Epub 2019 Feb 15.

Department of Cardiology, Kosuyolu Heart Education and Research Hospital, University of Health Sciences, 34844 Istanbul, Turkey.

In patients with acute myocardial infarction and multivessel disease, the timing of intervention to non-culprit lesions is still a matter of debate, especially in patients without shock. This study aimed to compare the effect of multivessel intervention, performed at index percutaneous coronary intervention (PCI) (MVI-I) or index hospitalization (MVI-S), on the 30-day results of acute myocardial infarction (AMI), and to investigate the effect of coronary lesion complexity assessed by the Syntax (Sx) score on the timing of multivessel intervention. We enrolled 180 patients with MVI-I, and 425 patients with MVI-S. Read More

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http://dx.doi.org/10.3390/medicina55020051DOI Listing
February 2019

Protective Effect of Extract against Irradiation-Induced Acute Hepatitis.

Int J Mol Sci 2019 Feb 15;20(4). Epub 2019 Feb 15.

National Institute of Cancer Research, National Health Research Institutes, Miaoli 35053, Taiwan.

Radiotherapy for treatment of hepatocellular carcinoma causes severe side effects, including acute hepatitis and chronic fibrosis. Complementary and alternative medicine (CAM) has emerged as an important part of integrative medicine in the management of diseases. (AC), a valuable medicinal fungus originally found only in Taiwan, has been shown to possess anti-oxidation, vaso-relaxtation, anti-inflammation, anti-hepatitis, and anti-cancer effects. Read More

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http://dx.doi.org/10.3390/ijms20040846DOI Listing
February 2019

Iron in Lung Pathology.

Pharmaceuticals (Basel) 2019 Feb 15;12(1). Epub 2019 Feb 15.

Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA.

The lung presents a unique challenge for iron homeostasis. The entire airway is in direct contact with the environment and its iron particulate matter and iron-utilizing microbes. However, the homeostatic and adaptive mechanisms of pulmonary iron regulation are poorly understood. Read More

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http://dx.doi.org/10.3390/ph12010030DOI Listing
February 2019

Gastroprotective effect of ethyl acetate extract from Avicennia schaueriana Stapf & Leechman and underlying mechanisms.

Biomed Pharmacother 2019 Feb 16;112:108582. Epub 2019 Feb 16.

Department of Antibiotics, Federal University of Pernambuco, Cidade Universitária, Av. Arthur de Sá, S/N, 50670-901, Recife, PE, Brazil. Electronic address:

Objective: Avicennia schaueriana Stapf is an endemic mangrove species widely used by traditional Brazilian communities as a folk remedy for the treatment of rheumatism, ulcers, and skin wounds. The aim of the present study was to evaluate the gastroprotective potential of the ethyl acetate extract from the leaves of A. schaueriana (As-AcOEt). Read More

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http://dx.doi.org/10.1016/j.biopha.2019.01.043DOI Listing
February 2019

Design and synthesis novel di-carbonyl analogs of curcumin (DACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI).

Eur J Med Chem 2019 Feb 12;167:414-425. Epub 2019 Feb 12.

Chemical Biology Research Center at School of Pharmaceutical Sciences, Wenzhou Medical University, 1210 University Town, Wenzhou, Zhejiang, 325035, China.

A novel series of di-carbonyl analogs of curcumin (DACs) were prepared and evaluated for their anti-inflammatory properties. Preliminary results showed that a vast majority of compounds tested in this study could effectively suppress LPS-induced production of tumor necrosis factor (TNF)-α and interleukin (IL)-6. Structure-activity relationships of the compounds were discussed. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.042DOI Listing
February 2019

Outcome after hemispherotomy in patients with intractable epilepsy: Comparison of techniques in the Italian experience.

Epilepsy Behav 2019 Feb 16;93:22-28. Epub 2019 Feb 16.

Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children Hospital, Rome, Italy. Electronic address:

Objective: The objective of the study was to evaluate clinical characteristics and outcome of hemispherotomy in children and adolescents with hemispheric refractory epilepsy in an Italian cohort of patients.

Methods: We retrospectively evaluated the clinical course and outcome of 92 patients with refractory epilepsy who underwent hemispherotomy in three Italian epilepsy centers between 2006 and 2016. Three different approaches for hemispherotomy were used: parasagittal, modified parasagittal, and lateral. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.006DOI Listing
February 2019

Obstetric and gynaecology trainees' knowledge of paediatric and adolescent gynaecology services in the UK: A national qualitative thematic analysis.

Eur J Obstet Gynecol Reprod Biol 2019 Feb 6;235:30-35. Epub 2019 Feb 6.

Addenbrooke's Hospital, Cambridge University Hospitals NHS Trust, Hills Road, West Midlands, Cambridge, United Kingdom.

Background: The British Society of Paediatric and Adolescent Gynaecology (BritSPAG) was created in 2000 with specific aims to include raising the profile of paediatric and adolescent gynaecology (PAG) within the United Kingdom (UK). The Society has since developed a set of clinical standards for all acute hospitals providing gynaecological services to enable successful provision of paediatric and adolescent gynaecology care.

Aims: To determine the depth of knowledge that obstetric and gynaecology trainees have with regards to the PAG services provided at their Hospital, reflecting how widely PAG services have had an impact on trainees. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.01.029DOI Listing
February 2019

Low-dose versus standard-dose intravenous alteplase for octogenerian acute ischemic stroke patients: A multicenter prospective cohort study.

J Neurol Sci 2019 Jan 29;399:76-81. Epub 2019 Jan 29.

School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan; Department of Public Health, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Background And Purpose: The optimal dose of alteplase for acute ischemic stroke among geriatric patients is unclear. We aimed to assess the efficacy and safety of a low-dose (0.6 mg/kg) and standard-dose (0. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.047DOI Listing
January 2019

Metastatic Subdural Hematoma with Dural Metastasis Secondary to Poorly Differentiated Adenocarcinoma of Unknown Origin.

World Neurosurg 2019 Feb 16. Epub 2019 Feb 16.

Department of Neurosurgery, Hofstra Northwell School of Medicine, Manhasset, NY. Electronic address:

Background: Metastatic subdural hematoma with dural metastasis in the setting of an underlying malignancy is a rare condition that is difficult to diagnose and associated with a poor prognosis. Knowledge of this rare entity is of a paramount importance to neurosurgeons as its diagnosis may affect the management plan and overall survival. Here, we report a rare case of atraumatic subdural hematoma with dural metastasis in a patient with poorly differentiated adenocarcinoma of unknown origin. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.271DOI Listing
February 2019

Acute exposure of common yabby (Cherax destructor) to the neonicotinoid pesticide.

Sci Total Environ 2019 Feb 14;665:718-723. Epub 2019 Feb 14.

University of Messina, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Viale F. Stagno D'Alcontres 31, 981 66 Messina, Italy. Electronic address:

Calypso 480 SC (CAL) is an insecticide containing the active substance thiacloprid (480g/L) belonging to the family of neonicotinoids. Crayfish represent an important component of aquatic ecosystems and are considered sensitive indicators of water pollution. The aim of this study was to investigate the effects of acute exposure of CAL on common yabby crayfish (Cherax destructor) at concentrations of 0. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.202DOI Listing
February 2019

Multicenter clinical experience with recombinant soluble thrombomodulin for disseminated intravascular coagulation associated with severe acute cholecystitis.

Thromb Res 2019 Feb 13;176:74-78. Epub 2019 Feb 13.

2nd Department of Internal Medicine, Osaka Medical College, Osaka, Japan.

Background: Severe acute cholecystitis (AC) is defined by the association of organ dysfunction, including hematological dysfunction, with AC. Severe AC is often complicated by disseminated intravascular coagulation (DIC), the diagnostic criteria of which overlap with AC-associated hematological dysfunction. Since the diagnosis of DIC often delays definitive surgical management of severe AC, treatment of DIC in this setting is clinically important. Read More

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http://dx.doi.org/10.1016/j.thromres.2018.12.025DOI Listing
February 2019

Engineering Human Ventricular Heart Tissue Based on Macroporous Iron Oxide Scaffolds.

Acta Biomater 2019 Feb 16. Epub 2019 Feb 16.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Key Laboratory of Clinical Geriatric Medicine, Fudan University, Shanghai 200032, China; Shanghai Key Laboratory of Birth Defect, Children's Hospital of Fudan University, Shanghai, 201102 China. Electronic address:

Myocardial infarction (MI) is a primary cardiovascular disease threatening human health and quality of life worldwide. The development of engineered heart tissues (EHTs) as a transplantable artificial myocardium provides a promising therapy for MI. Since most MIs occur at the ventricle, engineering ventricular-specific myocardium is therefore more desirable for future applications. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.024DOI Listing
February 2019

Fibre-enriched buckwheat pasta modifies blood glucose response compared to corn pasta in individuals with type 1 diabetes and celiac disease: acute randomized controlled trial.

Diabetes Res Clin Pract 2019 Feb 16. Epub 2019 Feb 16.

Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy. Electronic address:

Aim: People with type 1 diabetes and celiac disease (T1D&CD) have high blood glucose variability. Processed gluten-free foods have shown to induce a worse metabolic profile whereas naturally gluten-free foods may represent healthier options. On the other hand, dietary fibre has shown to reduce postprandial glycemic excursions in individuals with diabetes. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.02.013DOI Listing
February 2019

A comparison of interferon gene expression induced by influenza A virus infection of human airway epithelial cells from two different donors.

Virus Res 2019 Feb 16. Epub 2019 Feb 16.

Division of Biotechnology Review and Research II, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America.

Influenza is an acute respiratory disease that can cause local annual epidemics and worldwide pandemics of different morbidity and mortality. Our understanding of host factors that modulate the frequency and severity of influenza virus infections is less than complete. In this study, we examined the inter-individual variations in the innate immune responses to H1N1 and H3N2 influenza A viruses (IAV) using primary cultures of normal human bronchial epithelial (NHBE) cells derived from two different donors (D1 and D2). Read More

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http://dx.doi.org/10.1016/j.virusres.2019.02.002DOI Listing
February 2019

Added value of IgA antibodies against Zika virus non-structural protein 1 in the diagnosis of acute Zika virus infections.

J Virol Methods 2019 Feb 16. Epub 2019 Feb 16.

Institute for Experimental Immunology, Euroimmun AG, Seekamp 31, D-23560, Lübeck, Germany.

Zika virus (ZIKV) is a mosquito-borne flavivirus posing a public health threat due to its association with neurological complications in newborns and adults. In flavivirus-endemic areas, coming mosquito seasons will require the differentiation of primary versus secondary and acute versus past ZIKV/flavivirus infections. This is complicated by two major difficulties: [i] secondary infections often present with low or undetectable titres of specific IgM and early-positive IgG, [ii] previous flavivirus infection(s) or vaccinations cause elevated cross-reactivities. Read More

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http://dx.doi.org/10.1016/j.jviromet.2019.02.005DOI Listing
February 2019

Blood-derived DNA Methylation Signatures of Crohn's Disease and Severity of Intestinal Inflammation.

Gastroenterology 2019 Feb 16. Epub 2019 Feb 16.

Genetics and Molecular Biology Program, Emory University, Atlanta, GA, USA; Division of Pediatric Gastroenterology, Department of Pediatrics, Emory University School of Medicine & Children's Healthcare of Atlanta, Atlanta, GA, USA; Department of Human Genetics, Emory University, Atlanta, GA, USA. Electronic address:

Background & Aims: Crohn's disease is a relapsing and remitting inflammatory disorder with a variable clinical course. Although most patients present with an inflammatory phenotype (B1), approximately 20% of patients rapidly progresses to complicated disease, which includes stricturing (B2) within 5 years. We analyzed DNA methylation patterns in blood samples of pediatric patients with Crohn's disease at diagnosis and later time points to identify changes that associate with and might contribute to disease development and progression. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.270DOI Listing
February 2019

A new approach to hemostasis in acute variceal bleeding: Oh spray can you see?

Gastroenterology 2019 Feb 16. Epub 2019 Feb 16.

Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.02.018DOI Listing
February 2019

Explore potential plasma biomarkers of acute respiratory distress syndrome (ARDS) using GC-MS metabolomics analysis.

Clin Biochem 2019 Feb 16. Epub 2019 Feb 16.

Departmen of Emergency and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, China. Electronic address:

Objectives: The aim of this study was to analyse the metabolomics of patients with acute respiratory distress syndrome (ARDS) for the identification of metabolic markers with potential diagnostic and prognostic value.

Methods: The enrolled subjects included adult patients with ARDS that met the Berlin definition and healthy controls matched based on age, gender, and body mass index (BMI). Plasma samples were collected from 37 patients with ARDS and 28 healthy controls. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2019.02.009DOI Listing
February 2019

Readmissions following hospitalisations for cardiovascular disease: a scoping review of the Australian literature.

Aust Health Rev 2019 Feb 20. Epub 2019 Feb 20.

International studies suggest high rates of readmissions after cardiovascular hospitalisations, but the burden in Australia is uncertain. We summarised the characteristics, frequency, risk factors of readmissions and interventions to reduce readmissions following cardiovascular hospitalisation in Australia.A scoping review of the published literature from 2000-2016 was performed using Medline, EMBASE and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases and relevant grey literature. Read More

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http://dx.doi.org/10.1071/AH18028DOI Listing
February 2019

Torsion of a uterine leiomyoma - a rare cause of hemoperitoneum; a case report and review of the literature.

Med Ultrason 2019 Feb;21(1):77-82

1st Department of Obstetrics and Gynecology, University of Medecine and Pharmacy "Iuliu Hatieganu", Cluj Napoca, Romania.

Uterine leiomyomas are common benign uterine tumors but by contrast, their acute complications are very rare. We present an unusual case of 38-year-old woman that came to the emergency department with acute abdominal pain. The ultrasound revealed hemoperitoneum, a uterus with two intramural fibroids and a tender inhomogeneous pelvic mass that seems to connect with the uterus. Read More

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http://dx.doi.org/10.11152/mu-1784DOI Listing
February 2019

Understanding the role of echocardiography in remodeling after acute myocardial infarction and development of heart failure with preserved ejection fraction.

Med Ultrason 2019 Feb;21(1):69-76

Cardiology Department "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; Rehabilitation Hospital, Cluj-Napoca.

Despite the use of reperfusion therapies in the last decades, acute myocardial infarction further remains one of the most frequent causes of mortality. This is mainly caused by changes in the ventricular architecture leading to ventricular remodeling, followed by progressive development of heart failure. Transthoracic echocardiography is a non-invasive instrument which can provide information about the extent of the ischemic process and its consequences but can also predict the outcomes after myocardial infarction. Read More

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http://dx.doi.org/10.11152/mu-1768DOI Listing
February 2019

Association between physical activity and change in renal function in patients after acute myocardial infarction.

PLoS One 2019 19;14(2):e0212100. Epub 2019 Feb 19.

Department of Cardiology, Southern Tohoku General Hospital, Koriyama, Japan.

Background: Combined renal dysfunction worsens the subsequent prognosis in patients after acute myocardial infarction (AMI). Therefore, establishing a therapeutic modality to maintain or improve renal function in AMI patients is necessary. This study aimed to elucidate the association between physical activity level and change in renal function in such patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212100PLOS
February 2019

Seroprevalence of Q fever among high-risk occupations in the Ilam province, the west of Iran.

PLoS One 2019 19;14(2):e0211781. Epub 2019 Feb 19.

Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Tehran, Iran.

Background: Q fever is a zoonotic disease of great public health importance in Iran. This disease is presented with high phase I antibody development in chronic and high phase II antibody in the acute form of illness. This study was conducted to evaluate the seroprevalence of Q fever among high-risk occupations in the Ilam province in Western Iran. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211781PLOS
February 2019
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The impact of dementia on hospital outcomes for elderly patients with sepsis: A population-based study.

PLoS One 2019 19;14(2):e0212196. Epub 2019 Feb 19.

School of Medicine, Autonomous University of Madrid, Madrid, Spain.

Background: Prior studies have suggested that dementia adversely influences clinical outcomes and increases resource utilization in patients hospitalized for acute diseases. However, there is limited population-data information on the impact of dementia among elderly hospitalized patients with sepsis.

Methods: From the 2009-2011 National Hospital Discharge Database we identified hospitalizations in adults aged ≥65 years. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212196PLOS
February 2019

The Cost-Effectiveness of Interventions to Increase Utilization of Prone Positioning for Severe Acute Respiratory Distress Syndrome.

Crit Care Med 2019 Mar;47(3):e198-e205

Palliative and Advanced Illness Research (PAIR) Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

Objectives: Despite strong evidence supporting proning in acute respiratory distress syndrome, few eligible patients receive it. This study determines the cost-effectiveness of interventions to increase utilization of proning for severe acute respiratory distress syndrome.

Design: We created decision trees to model severe acute respiratory distress syndrome from ICU admission through death (societal perspective) and hospital discharge (hospital perspective). Read More

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http://dx.doi.org/10.1097/CCM.0000000000003617DOI Listing

Declining Mortality in Patients With Acute Respiratory Distress Syndrome: An Analysis of the Acute Respiratory Distress Syndrome Network Trials.

Crit Care Med 2019 Mar;47(3):315-323

Department of Emergency Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Objectives: There has been multiple advances in the management of acute respiratory distress syndrome, but the temporal trends in acute respiratory distress syndrome-related mortality are not well known. This study aimed to investigate the trends in mortality in acute respiratory distress syndrome patients over time and to explore the roles of daily fluid balance and ventilation variables in those patients.

Design: Secondary analysis of randomized controlled trials conducted by the Acute Respiratory Distress Syndrome Network from 1996 to 2013. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003499DOI Listing

IL-33-mediated IL-13 secretion by ST2+ Treg controls inflammation after lung injury.

JCI Insight 2019 Feb 19. Epub 2019 Feb 19.

Acute respiratory distress syndrome is an often fatal disease that develops after acute lung injury and trauma. How released tissue damage signals, or alarmins, orchestrate early inflammatory events is poorly understood. Herein we reveal that IL-33, an alarmin sequestered in the lung epithelium, is required to limit inflammation after injury due to an unappreciated capacity to mediate Foxp3+ Treg control of local cytokines and myeloid populations. Read More

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http://dx.doi.org/10.1172/jci.insight.123919DOI Listing
February 2019

Public Perceptions on Why Women Receive Less Bystander Cardiopulmonary Resuscitation Than Men in Out-of-Hospital Cardiac Arrest.

Circulation 2019 Feb;139(8):1060-1068

Center for Women's Health Research (S.M.P., C.K., S.L.D.), Department of Medicine, University of Colorado School of Medicine, Aurora.

Background: Women who suffer an out-of-hospital cardiac arrest receive bystander cardiopulmonary resuscitation (CPR) less often than men. Understanding public perceptions of why this occurs is a necessary first step toward equitable application of this potentially life-saving intervention.

Methods: We conducted a national survey of members of the public using Mechanical Turk, Amazon's crowdsourcing platform, to determine reasons why women might receive bystander CPR less often than men. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037692DOI Listing
February 2019

Systemic bile acids induce insulin resistance in a TGR5-independent manner.

Am J Physiol Endocrinol Metab 2019 Feb 19. Epub 2019 Feb 19.

Department of Molecular Physiology and Biophysics Vanderbilt Univ. School of Medicine Nashville, TN, United States.

Bile acids are involved in the emulsification and absorption of dietary fats as well as acting as signaling molecules. Recently, bile acid signaling through farnesoid X receptor (FXR) and G Protein-Coupled Bile Acid Receptor (TGR5) has been reported to elicit changes in not only bile acid synthesis but also metabolic processes including altering gluconeogenic gene expression and energy expenditure. A role for bile acids in glucose metabolism is also supported by a correlation between changes in the metabolic state of patients (i. Read More

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http://dx.doi.org/10.1152/ajpendo.00362.2018DOI Listing
February 2019

Contractile activity-specific transcriptome response to acute endurance exercise and training in human skeletal muscle.

Am J Physiol Endocrinol Metab 2019 Feb 19. Epub 2019 Feb 19.

Laboratory of Exercise Physiology, Institute of Biomedical Problems of the Russian Academy of Sciences. Faculty of Fundamental Medicine, M.V. Lomonosov Moscow State University, Russia.

Reduction in daily activity leads to dramatic metabolic disorders, while regular aerobic exercise training is effective for preventing this problem. The purpose of this study was to identify genes that are directly related to contractile activity in human skeletal muscle, regardless of the level of fitness. Transcriptome changes after the one-legged knee extension exercise in exercised and contralateral non-exercised vastus lateralis muscle of 7 males were evaluated by RNA-seq. Read More

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http://dx.doi.org/10.1152/ajpendo.00449.2018DOI Listing
February 2019

Indicator Amino Acid Oxidation Protein Requirement Estimate in Endurance-Trained Men 24h Post-Exercise Exceeds both the EAR and Current Athlete Guidelines.

Am J Physiol Endocrinol Metab 2019 Feb 19. Epub 2019 Feb 19.

Exercise Nutrition Research Laboratory, Western University, London, Canada.

Despite studies indicating increased protein requirements in endurance-trained (ET) individuals, the Institute of Medicine has concluded, that "no additional dietary protein is suggested for healthy adults undertaking resistance or endurance exercise" and the controversy regarding exercise effects on protein requirements continues. The objective of this study was to determine the dietary protein requirement of healthy young ET men (≥1 y training experience) 24h post-exercise (to minimize any acute effects of the previous training session) by measuring the oxidation of ingested L-[1-C] phenylalanine to CO in response to graded intakes of protein [Indicator Amino Acid Oxidation (IAAO) Technique]. Eight men (V ̇O, 64. Read More

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http://dx.doi.org/10.1152/ajpendo.00174.2018DOI Listing
February 2019

Outcomes and adverse effects associated with stereotactic body radiation therapy in dogs with nasal tumors: 28 cases (2011-2016).

J Am Vet Med Assoc 2019 Mar;254(5):602-612

OBJECTIVE To assess outcomes, factors associated with survival time, and radiation-induced toxicoses in dogs treated for nasal tumors with curative-intent stereotactic body radiation therapy (SBRT). DESIGN Retrospective case series. ANIMALS 28 client-owned dogs. Read More

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http://dx.doi.org/10.2460/javma.254.5.602DOI Listing

Simultaneous fluoroscopic-guided tibial plateau leveling and fracture reduction for the concurrent treatment of chronic cranial cruciate ligament tear and comminuted diaphyseal fracture of the tibia and fibula in a dog.

J Am Vet Med Assoc 2019 Mar;254(5):613-618

CASE DESCRIPTION A 12-year-old obese spayed female American Staffordshire Terrier was admitted for evaluation of acute non-weight-bearing lameness of the right pelvic limb attributed to motor vehicle-related trauma that occurred 2 hours previously. The owners reported a chronic, progressive weight-bearing lameness of the right pelvic limb secondary to a complete cranial cruciate ligament (CrCL) rupture that was diagnosed 6 months previously. They had declined surgery for CrCL repair because of the advanced age of the dog. Read More

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http://dx.doi.org/10.2460/javma.254.5.613DOI Listing

Comorbid Illness, Injuries and Health Insurance Subscription Among Self-Reported Mentally Disabled Subjects of Tamil Nadu, India.

J Insur Med 2019 Feb 19. Epub 2019 Feb 19.

Background: -Mentally Disabled (MD) subjects often have multiple co-morbidities and also experience injuries, acute and chronic illness like the general population. Details of such episodes and the impact of health insurance have not been described for Tamil Nadu, an Indian state population. This manuscript intends to report on this experience. Read More

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http://dx.doi.org/10.17849/insm-47-04-1-11.1DOI Listing
February 2019

Acute Cardiometabolic Effects of Interrupting Sitting with Resistance Exercise Breaks.

Appl Physiol Nutr Metab 2019 Feb 19. Epub 2019 Feb 19.

University of Pittsburgh, 6614, Health & Physical Activity, Pittsburgh, Pennsylvania, United States ;

Purpose: Interrupting prolonged sitting with light activity breaks, such as short walks, improves cardiometabolic outcomes, yet less is known about the impact of resistance exercise breaks. This study examined the effects of hourly, guidelines-based simple resistance exercise breaks on acute cardiometabolic health outcomes over a simulated work period.

Methods: Fourteen adults (age: 53. Read More

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http://dx.doi.org/10.1139/apnm-2018-0633DOI Listing
February 2019

Time Course of Recovery is Similar for the Back Squat, Bench Press, and Deadlift in Well-Trained Males.

Appl Physiol Nutr Metab 2019 Feb 19. Epub 2019 Feb 19.

Florida Atlantic University, Exercise Science and Health Promotion, Muscle Physiology Laboratory, Boca Raton, Florida, United States ;

This study examined the time course of recovery following resistance exercise sessions in the back squat, bench press, and deadlift. Twelve well-trained males (age: 24.5±3. Read More

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http://dx.doi.org/10.1139/apnm-2019-0004DOI Listing
February 2019

[TREATMENT DILEMMAS IN FULMINANT INTRACRANIAL HYPERTENSION].

Harefuah 2019 Feb;158(2):96-100

Department of Ophthalmology, Barzilai University Medical Center, Israel.

Introduction: Fulminant intracranial hypertension is a rare, acute presentation of idiopathic intracranial hypertension with rapid and devastating visual loss that can lead to blindness. As vision deteriorates quickly and often irreversibly, prevention of further visual loss requires emergent treatment to decrease intracranial pressure. The case presented is that of an 18 years old male with new symptoms of headaches and visual obscurations that had rapid progressive visual loss with findings of severe bilateral swollen discs. Read More

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February 2019

Increased serum adiponectin predicts improved coronary flow and clinical outcomes in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention.

J Clin Lab Anal 2019 Feb 19:e22864. Epub 2019 Feb 19.

Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: Previous studies suggested that adiponectin (APN) could ameliorate ischemia/reperfusion injury and endothelial dysfunction in patients with acute myocardial infarction. However, the relationship between serum APN level and coronary flow after primary percutaneous coronary intervention (PPCI) in patients with ST-segment elevation myocardial infarction (STEMI) is unclear.

Methods: A total of 144 patients with STEMI treated by PPCI were enrolled and divided into two groups based on the mean serum APN level on admission. Read More

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http://dx.doi.org/10.1002/jcla.22864DOI Listing
February 2019
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