Search Our Scientific Publications & Authors

Neuropediatrics 2019 Apr 22. Epub 2019 Apr 22.

CHRU de Brest, service de pédiatrie, Brest, France.

J Pharm Biomed Anal 2019 Apr 8;171:212-217. Epub 2019 Apr 8.

Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address:

Arsenic trioxide [AsO, arsenite (As) in solution] has been applied successfully for the treatment of acute promyelocytic leukemia (APL). The arsenic speciation analysis of urine is critical to reveal the metabolic mechanism and the relationship between arsenic species and the clinical response. To characterize the arsenic species in urine, a simple and robust HPLC-HG-AFS method was developed and validated to quantify the levels of arsenic species [As and its metabolites, monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and arsenate (As)] in urine samples from 66 patients with APL. Read More

Chemosphere 2019 Apr 15;227:598-605. Epub 2019 Apr 15.

Instituto Coral Vivo, Rua dos Coqueiros, Parque Yaya, Santa Cruz Cabrália, BA, 45807-000, Brazil; Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Av. Itália, Km 8, Rio Grande, RS, 96203-900, Brazil. Electronic address:

Coral reefs are subjected to climate change and are severely impacted by human activities, with copper (Cu) being a relevant physiological stressor for corals at local scale. The ecological relevance of parameters measured at biochemical or cellular level is now considered an extremely important feature in environmental studies, and can be used as early warning signs of environmental degradation. In this context, the effects of acute exposure (96 h) to Cu were assessed on the maximum photochemical efficiency of zooxanthellae (Fv/Fm) and on the activity of key enzymes [carbonic anhydrase (CA) and Ca-ATPase] involved in coral physiology using the scleractinian coral Mussismilia harttii as a biological model. Read More

Chemosphere 2019 Apr 12;227:580-588. Epub 2019 Apr 12.

Programa de Pós-graduação Em Ciências Fisiológicas, Universidade Federal Do Rio Grande, Avenida Itália Km 8, Campus Carreiros, 96203-900, Rio Grande, RS, Brazil; Instituto de Ciências Biológicas, Universidade Federal Do Rio Grande, Avenida Itália Km 8, Campus Carreiros, 96203-900, Rio Grande, RS, Brazil. Electronic address:

Copper ions (Cu) are essential to life maintenance, nonetheless, elevated concentrations can be hazardous. Acute and sub-chronic toxic effects of this metal are well known and are usually related to enzymatic inhibition, elevated ROS production and dysfunction of energy metabolism. Despite that, chronic studies are extremely rare. Read More

Leuk Res 2019 Apr 13;81:43-49. Epub 2019 Apr 13.

University of Colorado Division of Hematology, Aurora, CO, United States. Electronic address:

Background: Patients with relapsed and refractory (R/R) acute myeloid leukemia (AML) have limited treatment options. Genomically-defined personalized therapies are only applicable for a minority of patients. Therapies without identifiable targets can be effective but patient selection is challenging. Read More

Int J Nurs Stud 2019 Mar 28;95:40-48. Epub 2019 Mar 28.

University of Liverpool, United Kingdom; Broset Centre for Research and Education in Forensic Psychiatry, Norway.

Background: Physical restraint is a coercive intervention used to prevent individuals from harming themselves or others. However, serious adverse effects have been reported. Minimising the use of restraint requires a multimodal approach to target both organisational and individual factors. Read More

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania, USA. Electronic address:

Background: and Importance: Mechanical thrombectomy (MT) became a standard of care for stroke patients after the positive results of five randomized trials in 2015. However, elderly patients > 65 were excluded from those trials. Recent studies and clinical trials examining the efficacy of MT in patients over the age of 85 have shown that good outcomes can be achieved with careful patient selection. Read More

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China. Electronic address:

Objective: We test the hypothesis that low hemoglobin levels are associated with acute seizures following aneurysmal subarachnoid hemorrhage (aSAH).

Methods: Patients with ruptured intracranial aneurysms were enrolled in the observational cohort study that prospectively collected age, sex, symptom onset, history of diabetes and hypertension, history of coronary artery disease, temperature, Hunt-Hess grade, Fisher grade, aneurysm location, hemoglobin, hematocrit, serum potassium, sodium, calcium, phosphorus, iron, and modified Rankin Scale (mRS). Acute seizures were determined as seizures within one week following aSAH. Read More

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

The Japan Neurotrauma Data Bank Committee, The Japan Society of Neurotraumatology, Tokyo, Japan.

Objective: Developed countries have rapidly aging populations, and use of antithrombotic drugs is increasing. We investigated the effects of antithrombotic drugs and reversal of these drugs in geriatric traumatic brain injury (TBI) patients.

Methods: Age, gender, mechanism of injury, Glasgow Coma Scale on admission, head CT findings, antithrombotic therapy, acute exacerbation, and outcomes at discharge were examined in 711 patients with geriatric TBI complicated with traumatic intracranial hemorrhage using data from the Japan Neurotrauma Data Bank Project 2015 (JNTDB P2015). Read More

Int J Biochem Cell Biol 2019 Apr 19. Epub 2019 Apr 19.

Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic. Electronic address:

Nucleophosmin (NPM), one of the most abundant nucleolar proteins, has crucial functions in ribosome biogenesis, cell cycle control, and DNA-damage repair. In human cells, NPM occurs mainly in oligomers. It functions as a chaperone, undergoes numerous interactions and forms part of many protein complexes. Read More

Respir Physiol Neurobiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Movement and Sports Sciences, Ghent University, Watersportlaan 2, 9000 Ghent, Belgium. Electronic address:

Splenic contraction is an important response to acute apnea causing the release of red blood cells into blood circulation. Current literature shows higher spleen volumes and greater spleen contractions in trained apnea divers compared to untrained individuals, but the influence of training is presently unknown. Thirteen subjects daily performed five static apneas for 8 weeks. Read More

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Vascular Surgery - Policlinico Umberto I°; "Sapienza" University - Rome.

Aims: Visceral artery aneurysms (VAAs), although rare, represent a life-threatening disease with high mortality rates. With the more frequent use of diagnostic tests, there has been an incidental detection of these lesions which are mostly asymptomatic. It follows that surgeons are increasingly called to decide the most appropriate management of VAAs between an open surgical or endovascular approach and among the different endovascular options currently available. Read More

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery, Northwest Community Hospital, Arlington Heights IL.

Introduction: Pregnancy is a hypercoagulable state associated with a fivefold increase in risk of venous thromboembolism. Thrombolysis is the preferred level of care for patients with acute ilio-femoral deep vein thrombosis, however most studies exclude pregnant patients, highlighting the lack of data regarding the efficacy and safety of thrombolytic therapy for the mother and fetus.

Case Report: We describe successful use of thrombolytic therapy in conjunction with ultrasound to remove a large ileo-femoral deep vein thrombosis (DVT) in a first trimester patient with phlegmasia cerulea dolens. Read More

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiology Postgraduate Institute of Medical Education and Research, Chandigarh-160012, India.

Vascular complications such as renal artery or renal vein thrombosis and laceration, and iliac artery dissection are rarely encountered following renal transplantation. A timely management of these vascular complications is important to prevent ischemic injury of a transplanted kidney. We hereby report a 60-year-old male who had acute renal dysfunction due to iatrogenic left external iliac artery dissection, following renal transplantation. Read More

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Specialist, Emergency Medicine Clinic, Kayseri Training and Research Hospital, Kayseri, Turkey. Electronic address:

The Splenic infarct is a rare clinical condition seen in the emergency department and can mimic acute abdomen. Hematologic, vascular and thromboembolic events are considered in the etiology. Treatment options are varying between symptomatic treatment and splenectomy. Read More

J Ethnopharmacol 2019 Apr 19:111897. Epub 2019 Apr 19.

Pharmacen™, Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa; Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230, Odense M, Denmark; Celvivo IVS, Blommenslyst, Denmark. Electronic address:

Ethnopharmacology Relevance: Traditional herbal medicines are utilized by 27 million South Africans. Xysmalobium undulatum (Uzara) is one of the most widely used traditional medicinal plants in Southern Africa. A false belief in the safety of herbal medicine may result in liver injury. Read More

Biol Blood Marrow Transplant 2019 Apr 19. Epub 2019 Apr 19.

Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Guangzhou, 510515, China. Electronic address:

The optimal therapy for acute myeloid leukemia (AML) with FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) who relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains unclear. In this study, we retrospectively evaluated the efficacy of sorafenib combined with other therapeutic strategies as salvage therapy for these patients. A total of 83 AML with FLT3-ITD relapsing after allo-HSCT were enrolled in this study. Read More

Ann Allergy Asthma Immunol 2019 Apr 19. Epub 2019 Apr 19.

Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA; Medical Practice Evaluation Center, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address:

Semin Thorac Cardiovasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Division of Thoracic Surgery, East Carolina University, Greenville, NC.

Resuscitation 2019 Apr 19. Epub 2019 Apr 19.

Department of Epidemiology and Preventive Medicine, Monash University, Australia; Prehospital, Resuscitation and Emergency Care Research Unit, Curtin University, Australia; Alfred Hospital, Australia; Ambulance Victoria, Australia; Department of Community Emergency Health and Paramedic Practice, Monash University, Australia; SA Ambulance Service, Australia; Flinders University, Australia; St John Ambulance Western Australia, Australia; Warwick University, United Kingdom.

Background: Experimental and observational research suggests hyperoxia following resuscitation from cardiac arrest is associated with neurological injury and worse clinical outcomes. This paper describes the rationale and design of the EXACT trial. EXACT aims to determine whether reducing oxygen in the acute phase of post-resuscitation care for out-of-hospital cardiac arrest (OHCA) improves survival. Read More

Resuscitation 2019 Apr 19. Epub 2019 Apr 19.

Department of Heart Disease, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Aims: To assess characteristics and outcome of patients treated with Impella for acute myocardial infarction (AMI) complicated by severe cardiogenic shock (CS) or cardiac arrest (CA).

Methods And Results: From 2008 through 2017, 92 patients with AMI complicated by CS were treated with Impella. Survival varied according to clinical presentation. Read More

J Am Acad Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Dermatology, Johns Hopkins University, Baltimore, Maryland.

The field of dermatology has seen numerous therapeutic innovations in the past decade with platelet-rich plasma (PRP) recently garnering significant interest particularly in alopecia, acne scarring and skin rejuvenation. In other conditions of dermatology, such as chronic wounds and vitiligo, PRP has been investigated but has received less attention. The objective of this literature review was to focus on conditions of medical dermatology and to consolidate the available evidence of platelet-rich plasma for the practicing dermatologist. Read More

Neurochem Int 2019 Apr 19. Epub 2019 Apr 19.

Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Streptozotocin (STZ) is a glucosamine-nitrosourea commonly used to induce long-lasting models of diabetes mellitus and Alzheimer's disease. Direct toxicity of STZ on the pancreas and kidneys has been well characterized, but the acute effect of this compound on brain tissue has received less attention. Herein, we investigated the acute and direct toxicity of STZ on fresh hippocampal slices, measuring changes in BDNF and S100B secretion (two widely-used peripheral markers of brain injury), as well as glucose metabolism. Read More

Physiol Behav 2019 Apr 19. Epub 2019 Apr 19.

Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan. Electronic address:

Capsaicin (CAP), the pungent ingredient of hot red pepper, is a selective ligand for the heat-sensitive transient receptor potential V1 cation channel 1 (TRPV1). Although CAP has been traditionally used as the ingredient of spices for various foods in the world, the effect of oral intake of CAP on thermoregulation and locomotor activity, and CAP-induced activation of brain neural circuits are not well understood. In this study, therefore, we examined the effects of oral gavage of CAP on core body and tail surface temperature, locomotor activity, and Fos expression in thermoregulation- and sensory information-associated hypothalamic and medullary brain regions using freely moving mice. Read More

Ann Thorac Surg 2019 Apr 19. Epub 2019 Apr 19.

New York Presbyterian Brooklyn Methodist Hospital, 506 6(th) Street, Brooklyn, NY 11215; New York Presbyterian, Weill Cornell Medicine, New York, NY.

Our patient is a 58 year old woman with metastatic uterine leiomysarcoma with prior resection found to have an isolated metastatic lesion in the upper lobe of the right lung. She underwent a thoracotomy with right upper and middle lobectomy. Following her procedure, she developed acute ischemia of her left lower extremity secondary to an embolized tumor. Read More

J Pharm Sci 2019 Apr 19. Epub 2019 Apr 19.

Respiratory Technology, Woolcock Institute of Medical Research and Discipline of Pharmacology, Faculty of Medicine and Health, The University of Sydney, 431 Glebe Point Road, Glebe, NSW 2037, Australia. Electronic address:

The pathogenesis and progression of several lung disorders is propagated by inflammatory and oxidative processes which can be controlled by adjunctive inhaled therapies. The present study aimed to develop an inhalable dry powder formulation consisting of co-spray-dried urea-crosslinked hyaluronic acid and sodium ascorbyl phosphate (SD HA-CL - SAP), a novel combination which was recently shown to possess anti-inflammatory, antioxidant and wound healing properties. Native HA and SAP were co-spray dried (SD HA - SAP) and evaluated as control formulation. Read More

Gen Comp Endocrinol 2019 Apr 19. Epub 2019 Apr 19.

Department of Zoology, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand.

Receptors for follicle-stimulating hormone (Fshr), luteinizing hormone (Lhcgr1 and Lhcgr2) and androgens (Ara and Arb) transduce the hormonal signals that co-ordinate coordinate spermatogenesis, but the factors that regulate the abundance of these transducers in fish testes remain little-understood. To mend this paucity of information, we first determined changes in transcript abundance for these receptors (fshr, lhcgr1, ara and arb) during spermatogenesis induced by human chorionic gonadotropin (hCG) injection in the eel, Anguilla australis. We related our findings to testicular production of the fish androgen, 11-ketotestosterone (11-KT), and to the levels of the transcripts encoding steroidogenic acute regulatory protein (star) and 11β-hydroxylase (cyp11b), and subsequently evaluated the effects of hCG or 11-KT on mRNA levels of these target genes in vitro. Read More

Tex Med 2018 Jun 1;114(6):42-44. Epub 2018 Jun 1.

The proposed three-day limit on opioid prescriptions for acute pain would be one of the more impactful provisions for pain doctors and their patients. Exceptions would include prescriptions for chronic pain, cancer care, hospice or end-of-life care, and pain treatment that's part of palliative care. Read More

PLoS Pathog 2019 Apr 22;15(4):e1007653. Epub 2019 Apr 22.

Department of Microbiology and Immunology; University of Michigan Medical School; Ann Arbor, MI, United States of America.

The Gram-negative bacterium Proteus mirabilis is a common cause of catheter-associated urinary tract infections (CAUTI), which can progress to secondary bacteremia. While numerous studies have investigated experimental infection with P. mirabilis in the urinary tract, little is known about pathogenesis in the bloodstream. Read More

PLoS One 2019 22;14(4):e0215572. Epub 2019 Apr 22.

Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Childhood acute respiratory infection remains the commonest global cause of morbidity and mortality among under-five children. In Ethiopia, it remains the highest burden of the health care system. The problem varies in space and time, and exploring its spatial distribution has supreme importance for monitoring and designing effective intervention programs. Read More

PLoS One 2019 22;14(4):e0215514. Epub 2019 Apr 22.

Department of Clinical Laboratory, Beijing Tsinghua Chang-gung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, PR. China.

We retrospectively analyzed serum IgM antibodies (Abs) to influenza viruses from two tertiary hospitals in Beijing from December 2016 to February 2018. Samples from 36,792 patients, aged 0-98 years, were collected and tested. Among the patients, 923 children from two winter flu seasons were assayed with both antigens and IgM Abs to Flu A and Flu B and assigned as paired groups. Read More

PLoS One 2019 22;14(4):e0215143. Epub 2019 Apr 22.

Nuffield Centre for International Health and Development, University of Leeds, Leeds, United Kingdom.

Background: In Nigeria, recent reports suggest that dengue viruses could be a major cause of acute fevers. We sought to make a cross-sectional estimate of the prevalence of current and previous dengue infections in patients presenting with fever to healthcare centres in Cross River State Nigeria.

Methodology/principal Findings: This cross-sectional health facility survey recruited persons with temperature ≥38°C. Read More

PLoS One 2019 22;14(4):e0215101. Epub 2019 Apr 22.

CIUSSS du Nord-de-l'Île-de-Montréal, Hôpital Sacré-Cœur, Montréal, Canada.

Caspase-3 activation in the limbic system and depressive-like symptoms are observed after an acute myocardial infarction (MI) and studies suggest that inflammation may play a significant role. Combined treatment with the probiotic strains Bifidobacterium longum and Lactobacillus helveticus in rats has been shown to attenuate caspase-3 activation and depressive-like behaviour together with a reduction in pro-inflammatory cytokines. The present study was designed to determine the respective contribution of these two strains on caspase-3 activity in the limbic system and on depressive-like behaviour. Read More

J Trauma Acute Care Surg 2019 May;86(5):881-890

From the Elmezzi Graduate School of Molecular Medicine, (J.C., W-L.Y., P.W.); Center for Immunology and Inflammation, (J.C., W-L.Y., Z.W., P.W.) The Feinstein Institute for Medical Research, Manhasset; Department of Surgery, Zucker School of Medicine at Hofstra/Northwell, (W-L.Y., J.T.M., P.W.) Hempstead, New York.

Background: Hemorrhagic shock (HS) is a life-threatening condition resulting from rapid and significant loss of intravascular volume, leading to hemodynamic instability and death. Inflammation contributes to the multiple organ injury in HS. Type I interferons (IFNs), such as IFN-α and IFN-β, are a family of cytokines that regulate the inflammatory response through binding to IFN-α receptor (IFNAR) which consists of IFNAR1 and IFNAR2 chains. Read More

J Strength Cond Res 2019 Apr 17. Epub 2019 Apr 17.

Graduate Program in Physical Education of Federal University of Paraíba (UFPB), Paraíba, Brazil.

Costa, BDV, Ferreira, MEC, Gantois, P, Kassiano, W, Paes, ST, de Lima-Júnior, D, Cyrino, ES, and Fortes, LS. Acute effect of drop-set, traditional, and pyramidal systems in resistance training on neuromuscular performance in trained adults. J Strength Cond Res XX(X): 000-000, 2019-The aim of this study was to analyze the acute effects of resistance training (RT) systems on lower- and upper-limb performance in trained adults. Read More

Stroke 2019 May;50(5):1210-1215

From the Neurovascular Research Laboratory, Department of Radiology (F.S., M.B., T.Q., I.T., P.F., C.A.), Massachusetts General Hospital, Harvard Medical School, Charlestown.

Background and Purpose- Mechanisms contributing to acute hematoma growth in intracerebral hemorrhage are not well understood. Neuropathological studies suggest that the initial hematoma may create mass effect that can tear vessels in the vicinity by shearing, causing further bleeding and hematoma growth. Methods- To test this in mice, we simulated initial intracerebral hemorrhage by intrastriatal injection of a liquid polymer that coagulates upon contact with tissue and measured the presence and volume of bleeding secondary to the mass effect using Hemoglobin ELISA 15 minutes after injection. Read More

Stroke 2019 May;50(5):1275-1278

From the Department of Neuroradiology (J.F., M.B., H.K., S.G.), University Hospital Hamburg-Eppendorf, Germany.

Background and Purpose- Using a novel study design with virtual comparators based on predictive modeling, we investigated whether next-generation mechanical thrombectomy devices improve outcomes in patients with ischemic stroke. We hypothesized that this new study design shows that a next-generation mechanical thrombectomy system is superior to intravenous tPA (tissue-type plasminogen activator) therapy (IVT) alone. Methods- ERASER (Eric Acute Stroke Recanalization) was an investigator-initiated, prospective, multicenter, single-arm (virtual 2-arm) study that evaluated the effectiveness of a new recanalization device together with a specific intermediate catheter (Embolus Retriever with Interlinked Cages/SOFIA, Microvention) in stroke patients with internal carotid artery or middle cerebral artery occlusions. Read More

Stroke 2019 May;50(5):1074-1080

From the Department of Neurosurgery (P.H., N.S., O.G., C.M.S., C.J.G.), Geisinger, Danville, PA.

Background and Purpose- Accurate prediction of acute ischemic stroke (AIS) caused by anterior large vessel occlusion (LVO) that is amendable to mechanical thrombectomy remains a challenge. We developed and validated a prediction model for anterior circulation LVO stroke using past medical history elements present on admission and neurological examination. Methods- We retrospectively reviewed AIS patients admitted between 2009 and 2017 to 3 hospitals within a large healthcare system in the United States. Read More

Stroke 2019 May;50(5):1164-1171

Department of Neurology, Foch Hospital, Versailles Saint-Quentin en Yvelines University, Suresnes, France (B.L.).

Background and Purpose- Acute stroke patients with a large ischemic core may still benefit from mechanical thrombectomy (MT), but the predictors of clinical outcome are not well known after MT. We investigated the clinical and imaging factors associated with good outcome and mortality at 90 days in acute stroke patients with a large baseline ischemic core treated with MT. Methods- Data from the multicentric prospective ETIS (Endovascular Treatment in Ischemic Stroke) registry of consecutive acute ischemic stroke patients treated with MT from January 1, 2012, to August 31, 2016, were retrospectively analyzed. Read More

Stroke 2019 May;50(5):1124-1129

From the Vascular Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.-M.Y., X.-Q.Z., Y.-L.W., Z.-X.L., Y.-J.W.).

Background and Purpose- We aim to compare the risk of 1-year ischemic stroke recurrence and death for atrial fibrillation diagnosed after stroke (AFDAS), atrial fibrillation known before stroke (KAF), and sinus rhythm (SR). Methods- From June 2012 to January 2013, 19 604 patients with acute ischemic stroke were admitted to 219 urban hospitals in the China National Stroke Registry II. Based on heart rhythm assessed during admission, we classified patients as AFDAS, KAF, or SR. Read More

Stroke 2019 May;50(5):1089-1094

Departments of Pediatrics, Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas and Children's Health Dallas (M.M.D.).

Background and Purpose- Sickle cell disease (SCD) and arteriopathy are pediatric stroke risk factors that are not mutually exclusive. The relative contributions of sickled red blood cells and arteriopathy to stroke risk are unknown, resulting in unclear guidelines for primary and secondary stroke prevention when both risk factors are present. We hypothesized that despite similarities in clinical presentation and radiographic appearance of arteriopathies, stroke evaluation and management differ in children with SCD compared with those without SCD. Read More

Stroke 2019 May;50(5):1156-1163

Cerenovus, Galway Neuro Technology Centre, Ireland (S.D., R.M., M.G.).

Background and Purpose- Mechanical thrombectomy may involve multiple attempts to retrieve the occluding thrombus. This study examined the composition of thrombus fragments retrieved with each pass of a device during the thrombectomy procedure. Second, the per-pass composition was compared with procedural and clinical data including angiographic outcome and stroke etiology. Read More

Stroke 2019 May;50(5):1266-1269

Department of Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer-Sheva, Israel (J.O., R.V., A.F.), Soroka Medical Center, Beer-Sheva, Israel.

Background and Purpose- The diagnosis of transient ischemic attack is challenging. Evidence of acute ischemia on MRI diffusion-weighted imaging is highly variable and confirmed in only about one-third of patients. This study investigated the significance of blood-brain barrier dysfunction (BBBD) mapping in patients with transient neurological deficits, as a diagnostic and prognostic biomarker required for risk stratification and stroke prevention. Read More

Stroke 2019 May;50(5):1279-1281

Department of Neurosurgery (N.L.), Haukeland University Hospital, Bergen, Norway.

Background and Purpose- Tenecteplase represents a promising alternative to alteplase as thrombolytic treatment in acute ischemic stroke. There are limited data on tenecteplase 0.4 mg/kg in patients with increased stroke severity. Read More

Surg Infect (Larchmt) 2019 Apr 20. Epub 2019 Apr 20.

Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, New York.

Sepsis is an uncommon occurrence after appendectomy, but the morbidity and mortality of patients who develop sepsis after appendectomy remains exceedingly high. The purpose of this study is to identify risk factors and adverse post-operative outcomes associated with sepsis after appendectomy in adults. The American College of Surgery National Surgical Quality Improvement Program participant user database was queried from 2012 to 2015. Read More

Ocul Immunol Inflamm 2019 Apr 22:1-9. Epub 2019 Apr 22.

a Ocular inflammation and infection division, Department of Ophthalmology, Phramongkutklao hospital , Phramongkutklao college of Medicine , Bangkok , Thailand.

Background: Causes of uveitis vary upon the epidemiologic, racial, and geographical variations.

Objective: The objective of the study is to analyze pattern and outcome of uveitis in Phramongkutklao Hospital.

Methods: This is a retrospective study. Read More

J Child Adolesc Psychopharmacol 2019 Apr 19. Epub 2019 Apr 19.

1 Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.

Pediatric acute-onset neuropsychiatric syndrome (PANS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are subtypes of Obsessive-Compulsive Disorder (OCD) with suggested autoimmune etiology. Immunomodulatory treatments have been introduced as treatment options. A recent systematic review concluded that the evidence for all treatment options for PANS and PANDAS is inconclusive. Read More

Nephrol Nurs J 2019 Mar-Apr;46(2):145-154

Associate Editor of the Nephrology Nursing Journal.

This article provides a historical overview of some of the early nursing literature. These articles reveal early perceptions and writings about renal anatomy and physiology, and nursing implications for care, including acute and chronic kidney disease, peritoneal and hemodialysis, and kidney transplantation. Read More

J Biomed Mater Res B Appl Biomater 2019 Apr 22. Epub 2019 Apr 22.

Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.

Calcium phosphate-based biomaterials are extensively used for bone replacement and regeneration in orthopedic, dental, and maxillofacial surgical applications. The injury induced by surgical implantation of bone replacement graft materials initiates a cascade of host responses, starting with blood-biomaterial contact, protein adsorption on the material surface, blood coagulation, and leukocyte responses. During the initial acute inflammatory response, polymorphonuclear neutrophils (PMNs) and monocytes, abundant circulating leukocytes of the myeloid lineage, are recruited to the site of inflammation. Read More

J Pineal Res 2019 Apr 22:e12581. Epub 2019 Apr 22.

State Key Laboratory for Oncogenes and Related Genes, Division of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai Cancer Institute, Shanghai, China.

Rupture of vulnerable plaques is the main trigger of acute cardio-cerebral vascular events, but mechanisms responsible for transforming a stable atherosclerotic into a vulnerable plaque remain largely unknown. Melatonin, an indoleamine hormone secreted by the pineal gland, plays pleiotropic roles in the cardiovascular system; however, the effect of melatonin on vulnerable plaque rupture and its underlying mechanisms remain unknown. Here, we generated a rupture-prone vulnerable carotid plaque model induced by endogenous renovascular hypertension combined with low shear stress in hypercholesterolemic ApoE mice. Read More