Transplantation 2016 Dec 8. Epub 2016 Dec 8.
aNorton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, US bDepartments of Genetics and cPediatrics, Washington University School of Medicine, St. Louis, MO, US dCincinnati Children's Hospital Medical Center, Cincinnati, OH, US eDepartment of Medicine, Recanati Miller Transplant Institute and Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, US.
: Acute rejection (AR) and development of chronic rejection, bronchiolitis obliterans syndrome (BOS), remain major limiting factors for lung transplantation (LTx). This retrospective study is to identify differentially expressed circulating microRNAs (miRNAs) that associate with development of AR and BOS in pediatric lung transplant recipients (LTxR).Methods
: We determined the circulating levels of 7 selected candidate miRNAs in 14 LTxR with AR, 7 with BOS, and compared them against 13 stable pediatric LTxR at 1, 6, and 12 months following LTx. Read More