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    1888 results match your criteria Acute Febrile Neutrophilic Dermatosis

    1 OF 38

    Dietary and commercialized fructose: Sweet or sour?
    Int Urol Nephrol 2017 Feb 16. Epub 2017 Feb 16.
    School of Medicine, Koç University, Rumelifeneri Yolu, Sariyer, 34450, Istanbul, Turkey.
    Metabolic syndrome and diabetes are main health problems of modern life in the twenty-first century. Alarming ratios of global prevalence lead to conduct more and more researches about etiological factors and pathogenesis. Disease mechanism is elementary for advancing more efficient and practicable treatment methods. Read More

    Azathioprine Hypersensitivity Syndrome: Two Cases of Febrile Neutrophilic Dermatosis Induced by Azathioprine.
    Case Rep Dermatol 2017 Jan-Apr;9(1):6-11. Epub 2017 Jan 19.
    Paul Sabatier University, University Hospitals of Toulouse, Toulouse, France; Department of Dermatology, University Hospitals of Toulouse, Toulouse, France.
    Background: Azathioprine is an immunosuppressive agent used in the treatment of immune-mediated diseases. Azathioprine hypersensitivity syndrome is a rare adverse reaction occurring a few days to weeks after the administration of azathioprine.

    Case 1: A 36-year-old male with ulcerative colitis presented with erythematous plaques, pustules and erosions on the lower back, buttocks and thighs associated with high fever (39°C) 2 weeks after the initiation of azathioprine 100 mg/day. Read More

    Cutaneous adverse effects of the immune checkpoint inhibitors.
    Curr Probl Cancer 2016 Dec 14. Epub 2016 Dec 14.
    Section of Dermatology, Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.
    The immune checkpoint targeted agents, anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and anti-programed cell death 1 (PD-1) or anti-programmed death ligand 1 (PD-L1) inhibitors are frequently associated with cutaneous side effects that are often dose limiting and can lead to discontinuation of therapy. Ipilimumab, a CTLA-4 inhibitor, is most commonly associated with a morbilliform eruption on the trunk and extremities and pruritus. More severe cutaneous toxicities reported include toxic epidermal necrolysis and severe drug rash with eosinophila and systemic symptoms. Read More

    Necrotizing Soft Tissue Infection or Sweet Syndrome: Surgery Versus No Surgery?: A Case Report.
    A A Case Rep 2017 Feb 1. Epub 2017 Feb 1.
    From the *Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts; †Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts; ‡Department of Otolaryngology, Massachusetts Eye & Ear Infirmary, Boston, Massachusetts; §Tufts University School of Medicine, Boston, Massachusetts; ‖Harvard Medical School, Boston, Massachusetts.
    The authors report a case of necrotizing Sweet syndrome in a 24-year-old transsexual male who presented with recurrent myonecrosis of the neck/upper chest. On index admission, computer tomography revealed gas and fat stranding of the sternocleidomastoid and pectoralis major muscle-findings suggestive of a necrotizing soft tissue infection. Despite debridement procedures and intravenous antibiotic therapy, myonecrosis of the affected areas persisted. Read More

    Panniculitis: A summary.
    Semin Diagn Pathol 2016 Dec 27. Epub 2016 Dec 27.
    Section of Dermatopathology,Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Charlottesville, VA, USA. Electronic address:
    The diagnosis of panniculitis is felt to be a confusing topic by some pathologists. This summarical article presents inflammatory diseases of the subcutis in a systematic fashion, based on whether they are centered on fibrovascular septa or the adipose lobules, and whether morphologic vasculitis is present or not. Septocentric, non-vasculitis disorders include erythema nodosum, panniculitis that follows the use of "biological" therapeutic agents, lipodermatosclerosis, post-irradiation panniculitis, morphea profunda, and necrobiosis lipodica profunda. Read More

    Disorders characterized by predominant or exclusive dermal inflammation.
    Semin Diagn Pathol 2016 Dec 14. Epub 2016 Dec 14.
    Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Room 3020 University of Virginia Hospital, 1215 Lee Street, Charlottesville, VA 22908-0214, USA. Electronic address:
    Some cutaneous inflammatory disorders are typified by a predominant or exclusive localization in the dermis. They can be further subdivided by the principal cell types into lymphocytic, neutrophilic, and eosinophilic infiltrates, and mixtures of them are also seen in a proportion of cases. This review considers such conditions. Read More

    Age-Related Changes in Gustatory, Homeostatic, Reward, and Memory Processing of Sweet Taste in the Metabolic Syndrome: An fMRI Study.
    Perception 2017 Jan 1:301006616686097. Epub 2017 Jan 1.
    Department of Psychology, San Diego State University, CA, USA; San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, CA, USA; Division of Head and Neck Surgery, University of California San Diego School of Medicine, CA, USA.
    Age affects the human taste system at peripheral and central levels. Metabolic syndrome is a constellation of risk factors (e.g. Read More

    Clinicopathologic, immunophenotyping and cytogenetic analysis of Sweet syndrome in Egyptian patients with acute myeloid leukemia.
    Pathol Res Pract 2017 Feb 26;213(2):143-153. Epub 2016 Oct 26.
    Department of Clinical Pathology, Banha University, Banha, Egypt. Electronic address:
    Background: Sweet syndrome (SS) is an uncommon dermatologic disorder that could be associated with hematologic malignancies.

    Objective: To describe the clinicopathologic, immunophenotyping and cytogenetic characteristics of SS in Egyptian patients with acute myeloid leukemia (AML).

    Methods: The study was conducted during the period from April 2011 to March 2015. Read More

    Sweet syndrome: a painful reality.
    BMJ Case Rep 2016 Dec 23;2016. Epub 2016 Dec 23.
    St John Hospital and Medical Center, Detroit, USA.
    Sweet syndrome is a rare disorder that is manifested by constellation of clinical features, including fever, neutrophilic leucocytosis, raised painful plaques on skin and dermal infiltration by neutrophils. Numerous aetiological associations have been reported in the literature, including various haematological malignancies and drugs. Our case was peculiar because of association of capecitabine and Sweet syndrome in rectal cancer. Read More

    A case of Sweet's syndrome associated with uveitis in a young male with ulcerative colitis.
    Rom J Morphol Embryol 2016 ;57(3):1145-1147
    2nd Department of Internal Medicine, University of Medicine and Pharmacy of Tirgu Mures, Romania;
    Sweet's syndrome is rare acute febrile neutrophilic dermatosis whose onset is either idiopathic or associated with other underlying conditions, such as infections, autoimmune diseases, pregnancy, use of certain medications, or malignancy. We report the case of a young male with known history of ulcerative colitis and abrupt onset of high fever, malaise, blurred vision and eruption of painful erythematous nodules and papules, localized on the head, neck, trunk and upper limbs. Ophthalmological examination established the diagnosis of anterior uveitis. Read More

    Role of Circulating microRNAs in the Immunopathogenesis of Rejection Following Pediatric Lung Transplantation.
    Transplantation 2016 Dec 8. Epub 2016 Dec 8.
    aNorton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, US bDepartments of Genetics and cPediatrics, Washington University School of Medicine, St. Louis, MO, US dCincinnati Children's Hospital Medical Center, Cincinnati, OH, US eDepartment of Medicine, Recanati Miller Transplant Institute and Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, US.
    Background: Acute rejection (AR) and development of chronic rejection, bronchiolitis obliterans syndrome (BOS), remain major limiting factors for lung transplantation (LTx). This retrospective study is to identify differentially expressed circulating microRNAs (miRNAs) that associate with development of AR and BOS in pediatric lung transplant recipients (LTxR).

    Methods: We determined the circulating levels of 7 selected candidate miRNAs in 14 LTxR with AR, 7 with BOS, and compared them against 13 stable pediatric LTxR at 1, 6, and 12 months following LTx. Read More

    Acral manifestations of Sweet syndrome (neutrophilic dermatosis of the hands).
    Clin Dermatol 2017 Jan - Feb;35(1):81-84. Epub 2016 Sep 12.
    Istanbul University Cerrahpaşa Medical Faculty, Istanbul, Turkey.
    Neutrophilic dermatosis of the hand (NDH) is a rare localized variant of the syndrome, originally described two decades ago by Strutton et al. The lesions of NDH and Sweet syndrome are similar, as indicated in the first report of NDH. Both diagnoses are characterized by an acute onset of fever, leukocytosis, and tender, erythematous infiltrated plaques. Read More

    Association of Odor Thresholds and Responses in Cerebral Blood Flow of the Prefrontal Area during Olfactory Stimulation in Patients with Multiple Chemical Sensitivity.
    PLoS One 2016 9;11(12):e0168006. Epub 2016 Dec 9.
    Department of Anatomy and Cellular Biology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
    Multiple chemical sensitivity (MCS) is a disorder characterized by nonspecific and recurrent symptoms from various organ systems associated with exposure to low levels of chemicals. Patients with MCS process odors differently than controls do. Previously, we suggested that this odor processing was associated with increased regional cerebral blood flow (rCBF) in the prefrontal area during olfactory stimulation using near-infrared spectroscopic (NIRS) imaging. Read More

    Citrus psorosis virus coat protein-derived hairpin construct confers stable transgenic resistance in citrus against psorosis A and B syndromes.
    Transgenic Res 2016 Nov 28. Epub 2016 Nov 28.
    Instituto de Biotecnología y Biología Molecular, CCT-La Plata, CONICET - UNLP, calles 47 y 115, 1900, La Plata, Buenos Aires, Argentina.
    Citrus psorosis virus (CPsV) is the causal agent of psorosis, a serious and widespread citrus disease. Two syndromes of psorosis, PsA and PsB, have been described. PsB is the most aggressive and rampant form. Read More

    Rapid test for lung maturity, based on spectroscopy of gastric aspirate, predicted respiratory distress syndrome with high sensitivity.
    Acta Paediatr 2017 Mar 20;106(3):430-437. Epub 2016 Dec 20.
    Departments of Pediatrics, Holbaek University Hospital, Holbaek, Denmark.
    Aim: Respiratory distress syndrome (RDS) is a major cause of mortality and morbidity in premature infants. By the time symptoms appear, it may already be too late to prevent a severe course, with bronchopulmonary dysplasia or mortality. We aimed to develop a rapid test of lung maturity for targeting surfactant supplementation. Read More

    [Cutaneous involvement in chronic inflammatory bowel disease : Crohn's disease and ulcerative colitis].
    Hautarzt 2016 Dec;67(12):940-947
    Abteilung für Dermatologie und Venerologie, Krankenanstalt Rudolfstiftung, Juchgasse 25, 1030, Wien, Österreich.
    Background: Over recent decades, both the incidence and prevalence of chronic inflammatory bowel disease have continued to rise in industrialized countries; the disease is frequently associated with extracutaneous involvement and comorbidity.

    Objectives: The purpose of this work was to investigate the frequency and specificity of mucocutaneous manifestations in Crohn's disease (CD) and ulcerative colitis (UC).

    Materials And Methods: An extensive search in peer-reviewed journals via PubMed was performed; presented is a summary and analysis of various studies and data, including data of patients treated at our department. Read More

    [Chronic recurrent annular neutrophilic dermatosis].
    Ann Dermatol Venereol 2016 Nov 4. Epub 2016 Nov 4.
    Département de dermatologie, hôpital Saint-Eloi, CHRU de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 5, France; Université de Montpellier, 163, rue Auguste-Broussonnet, 34090 Montpellier, France; UFR de pharmacie, Inserm U1058, 15, avenue Charles-Flahaut, 34093 Montpellier cedex 5, France. Electronic address:
    Background: Chronic recurrent annular neutrophilic dermatosis (CRAND) is a rare form of neutrophilic dermatosis characterised by chronic annular progression, histological impairment similar to that seen in Sweet's syndrome and the absence of association with generalised signs, abnormal laboratory values or underlying systemic disease. Herein we report two new cases.

    Patients And Methods: Case n(o) 1. Read More

    Baseline reef health surveys at Bangka Island (North Sulawesi, Indonesia) reveal new threats.
    PeerJ 2016 25;4:e2614. Epub 2016 Oct 25.
    Environmental Sustainability Research Centre, University of Derby , Derby , United Kingdom.
    Worldwide coral reef decline appears to be accompanied by an increase in the spread of hard coral diseases. However, whether this is the result of increased direct and indirect human disturbances and/or an increase in natural stresses remains poorly understood. The provision of baseline surveys for monitoring coral health status lays the foundations to assess the effects of any such anthropogenic and/or natural effects on reefs. Read More

    Leukemia Cutis: A Report of 17 Cases and a Review of the Literature.
    Actas Dermosifiliogr 2016 Nov 20;107(9):e65-e69. Epub 2016 May 20.
    Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España; Universidad de Valencia, Valencia, España.
    Dermatologic manifestations of leukemia can be both specific and nonspecific (e.g., opportunistic infections, purpura and ecchymosis, Sweet syndrome). Read More

    Xanthomatized Neutrophilic Dermatosis in a Patient With Myelodysplastic Syndrome.
    Am J Dermatopathol 2016 Oct 18. Epub 2016 Oct 18.
    *Division of Dermatology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Gahanna, OH; and †Department of Pathology, University of Virgina, Charlottesville, VA.
    We present an original case report of a 58-year-old man with a history of histiocytoid Sweet and myelodysplastic syndrome who presented with a new onset of tender plaques on his oral commissures. A biopsy revealed a dense dermal neutrophilic infiltrate, leukocytoclasis without frank vasculitis, and, most notably, the presence of many xanthomatized cells. Clinical presentation and histologic features were most consistent with an acute neutrophilic dermatosis, which we believe to be a xanthomized variant of Sweet syndrome. Read More

    Elevated 18F-FDG Uptake in Skeletal Muscles Rather Than Cutaneous Foci in a Patient With Sweet's Syndrome.
    Clin Nucl Med 2016 Dec;41(12):938-940
    From the Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.
    A 64-year-old man was admitted to our hospital with a history of recurrent fever lasting 2 months. The initial physical examination for the patient showed normal cutaneous signs. An elevated uptake of tracer in skeletal muscles was observed by F-FDG PET/CT imaging. Read More

    A not-so-sweet diagnosis - leukocytoclastic vasculitis masquerading as squamous cell carcinoma.
    Int Wound J 2016 Sep 29. Epub 2016 Sep 29.
    The Welsh Centre for Burns and Plastic Surgery, Morriston Hospital, Swansea, UK.
    Leukocytoclastic vasculitis (LCV) is a rare small-vessel vasculitis characterised by neutrophilic inflammation of post-capillary venules. Incidence varies from 3 to 4.5 per 100 000 people per year. Read More

    Sweet syndrome: long-term follow-up of 138 patients.
    Clin Exp Dermatol 2016 Oct;41(7):741-6
    Department of Dermatology, Hospital de Bellvitge, IDIBELL, University of Barcelona, Barcelona, Spain.
    Background: Several studies support a strong association of Sweet syndrome (SS) with malignancy. However, only a few studies analysing the clinical features of malignancy-associated SS have been published in recent years.

    Aim: To retrospectively study the clinical features of SS that could predict the development of associated malignancies and to analyse the development of malignant neoplasia during long-term follow-up of patients with SS. Read More

    Neuro sweet syndrome: a systematic review. A rare complication of Sweet syndrome.
    Acta Neurol Belg 2016 Sep 22. Epub 2016 Sep 22.
    DISSAL-Section of Dermatology-IRCCS Azienda Universitaria Ospedaliera San Martino-IST, Largo Rosanna Benzi 10, 16132, Genoa, Italy.
    Sweet's syndrome (SS) is an inflammatory disease characterized by fever, leucocytosis and distinctive skin lesions that histologically consist of a dermal infiltrate of neutrophils with nuclear fragmentation. Aseptic neutrophilic inflammation may occur also in other organs. Central nervous system involvement in SS, Neuro-Sweet's syndrome (NSS), is rare and reported especially among Asian patients. Read More

    Familial deletion of the HOXA gene cluster associated with Hand-Foot-Genital syndrome and phenotypic variability.
    Am J Med Genet A 2017 Jan 20;173(1):221-224. Epub 2016 Sep 20.
    Pediatric Endocrinology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.
    Hand-Foot-Genital syndrome is a rare autosomal dominant condition characterized by distal limb anomalies and urogenital malformations. This disorder is associated with loss-of-function mutations in the HOXA13 gene. HOXA13 plays an important role in the development of distal limbs and lower genitourinary tract of the fetus. Read More

    European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2016 Update.
    Neonatology 2017 21;111(2):107-125. Epub 2016 Sep 21.
    Regional Neonatal Unit, Royal Maternity Hospital, Belfast, UK.
    Advances in the management of respiratory distress syndrome (RDS) ensure that clinicians must continue to revise current practice. We report the third update of the European Guidelines for the Management of RDS by a European panel of expert neonatologists including input from an expert perinatal obstetrician based on available literature up to the beginning of 2016. Optimizing the outcome for babies with RDS includes consideration of when to use antenatal steroids, and good obstetric practice includes methods of predicting the risk of preterm delivery and also consideration of whether transfer to a perinatal centre is necessary and safe. Read More

    Lack of evidence for germline RNF43 mutations in patients with serrated polyposis syndrome from a large multinational study.
    Gut 2016 Aug 31. Epub 2016 Aug 31.
    Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia Envoi Specialist Pathologists, Herston, Queensland, Australia School of Medicine, The University of Queensland, Herston, Queensland, Australia.

    Oral sensory nerve damage: Causes and consequences.
    Rev Endocr Metab Disord 2016 Jun;17(2):149-58
    Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, 572 Newell Drive, P.O. Box 110370, Gainesville, FL, 32611-0370, USA.
    Oral sensations (i.e., taste, oral somatosensation, retronasal olfaction) are integrated into a composite sense of flavor, which guides dietary choices with long-term health impact. Read More

    [Clinical analysis of Sweet syndrome with myelodysplasia syndrome].
    Zhonghua Yi Xue Za Zhi 2016 Jun;96(22):1755-7
    Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
    Objective: To study the clinical, histopathological and therapeutic features of Sweet syndrome with myelodysplastic syndrome (MDS).

    Methods: The clinical data of 3 patients with Sweet syndrome and MDS diagnosed at Peking Union Medical College Hospital between October 1988 and November 2015 were reviewed. The laboratory test results, histopathological findings, and therapeutic regimens of these patients were analyzed retrospectively. Read More

    Paraneoplastic pemphigus as a presentation of acute myeloid leukemia: Early diagnosis and remission.
    Hematol Oncol Stem Cell Ther 2016 Jun 23. Epub 2016 Jun 23.
    Department of Hematology and Cellular Therapy, Western Pennsylvania Cancer Institute, Pittsburgh, PA, USA.
    Skin lesions are frequently encountered in clinical practice which can be a presentation of systemic diseases not excluding an occult malignancy. Commonly reported paraneoplastic dermatologic manifestations include acanthosis nigricans, dermatomyositis, erythroderma, hypertrophic osteoarthropathy, Sweet syndrome, and paraneoplastic pemphigus (PNP). PNP is a rare autoimmune mucocutaneous disease characterized by severe stomatitis, polymorphic skin eruptions, and associated underlying neoplasms most commonly non-Hodgkin's lymphoma, chronic lymphocytic leukemia, and Castleman disease. Read More

    Autoimmunity and Inflammation in Myelodysplastic Syndromes.
    Acta Haematol 2016 24;136(2):108-17. Epub 2016 Jun 24.
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Mass., USA.
    Autoimmune and inflammatory conditions (AICs) are encountered in up to 25% of patients with myelodysplastic syndromes (MDS). A wide range of AICs have been reported in association with MDS and can range from limited clinical manifestations to systemic diseases affecting multiple organs. Vasculitides, connective tissue diseases, and inflammatory arthritis are frequently reported in different studies; noninfectious fever and constitutional symptoms at presentation are common. Read More

    Taste and smell function in testicular cancer survivors treated with cisplatin-based chemotherapy in relation to dietary intake, food preference, and body composition.
    Appetite 2016 Oct 10;105:392-9. Epub 2016 Jun 10.
    Top Institute Food and Nutrition, Wageningen, The Netherlands; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:
    Background: Chemotherapy can affect taste and smell function. This may contribute to the high prevalence of overweight and metabolic syndrome in testicular cancer survivors (TCS). Aims of the study were to evaluate taste and smell function and possible consequences for dietary intake, food preference, and body composition in TCS treated with cisplatin-based chemotherapy. Read More

    [An original revealing mode of sarcoidosis: Sweet's syndrome].
    Pan Afr Med J 2016 24;23:122. Epub 2016 Mar 24.
    Service de Pneumo-phtisiologie, Hôpital Moulay Youssef, CHU Rabat, Rabat Maroc.
    Sweet's syndrome is a neutrophilic dermatosis which usually presents as an idiopathic disorder. The combination of Sweet's syndrome and sarcoidosis is rare. We report the clinical case of a Sweet's syndrome revealing sarcoidosis. Read More

    Inflammatory and glandular skin disease in pregnancy.
    Clin Dermatol 2016 May-Jun;34(3):335-43. Epub 2016 Feb 11.
    Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island; Department of Dermatology, Rhode Island Hospital, Providence, Rhode Island.
    A switch from cell-mediated to humoral immunity (helper T 1 [Th1] to helper T 2 [Th2] shift) during gestation plays a key role in placental immune tolerance. As a result, skin diseases that are Th2 mediated often worsen, whereas skin diseases that are Th1 mediated often improve during gestation. Also, due to fluctuations in glandular activity, skin diseases involving sebaceous and eccrine glands may flare, whereas those involving apocrine glands may improve during pregnancy. Read More

    Sweet Syndrome Associated with Upper Respiratory Infection and Amoxicillin Use.
    Cureus 2016 Apr 12;8(4):e568. Epub 2016 Apr 12.
    School of Medicine, Yale University.
    Sweet syndrome (acute febrile neutrophilic dermatosis) is an uncommon dermatologic eruption characterized by acute onset of painful papules, plaques or nodules on the skin that are red, blue, or violaceous in color. It has been associated with various infections, medications, and malignancies. Here we report the case of a middle-aged male who presents with Sweet syndrome after an upper resipiratory infection and while using amoxicillin. Read More

    Ticagrelor-induced Sweet Syndrome: an unusual dermatologic complication after percutaneous coronary intervention.
    Cardiovasc Interv Ther 2016 May 4. Epub 2016 May 4.
    Division of Cardiovascular Diseases, University of Louisville, Louisville, KY, 40202, USA.
    A 73-year-old male underwent cardiac catheterization and received two Everolimus drug eluting stents for 80 % stenotic lesions in the left anterior descending and right coronary arteries. He was discharged on aspirin and ticagrelor. He started noticing progressive multiple painful hemorrhagic bullae on the palms of both hands. Read More

    Low-calorie sweetener use and energy balance: Results from experimental studies in animals, and large-scale prospective studies in humans.
    Physiol Behav 2016 Oct 26;164(Pt B):517-23. Epub 2016 Apr 26.
    Department of Medicine, The University of Texas Health Science Center at San Antonio, Texas, United States. Electronic address:
    For more than a decade, pioneering animal studies conducted by investigators at Purdue University have provided evidence to support a central thesis: that the uncoupling of sweet taste and caloric intake by low-calorie sweeteners (LCS) can disrupt an animal's ability to predict the metabolic consequences of sweet taste, and thereby impair the animal's ability to respond appropriately to sweet-tasting foods. These investigators' work has been replicated and extended internationally. There now exists a body of evidence, from a number of investigators, that animals chronically exposed to any of a range of LCSs - including saccharin, sucralose, acesulfame potassium, aspartame, or the combination of erythritol+aspartame - have exhibited one or more of the following conditions: increased food consumption, lower post-prandial thermogenesis, increased weight gain, greater percent body fat, decreased GLP-1 release during glucose tolerance testing, and significantly greater fasting glucose, glucose area under the curve during glucose tolerance testing, and hyperinsulinemia, compared with animals exposed to plain water or - in many cases - even to calorically-sweetened foods or liquids. Read More

    Acute febrile neutrophilic dermatosis associated with JAK-2 positive myeloproliferative disorder.
    BMJ Case Rep 2016 Apr 26;2016. Epub 2016 Apr 26.
    Department of Medicine, NHS Forth Valley & University of Edinburgh, Larbert, UK.
    We present a case of a 77-year-old man with a history of myeloproliferative disorder. He was admitted with a 2-week history of erythaema, swelling and significant pain of the right forearm following a mechanical fall at home, which had caused a skin laceration. During his admission, he developed ongoing intermittent fever and persistently elevated C reactive protein, and total white cell count. Read More

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