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    2029 results match your criteria Acute Febrile Neutrophilic Dermatosis

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    Neutrophilic dermatoses. Part I. Pathogenesis, Sweet syndrome, neutrophilic eccrine hidradenitis, and Behçet's disease.
    J Am Acad Dermatol 2018 Apr 10. Epub 2018 Apr 10.
    Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address:
    Neutrophilic dermatoses are a heterogeneous group of inflammatory skin disorders that present with unique clinical features, but are unified by the presence of a sterile, predominantly neutrophilic infiltrate on histopathology. The morphology of cutaneous lesions associated with these disorders is heterogeneous, which renders diagnosis challenging. Moreover, a thorough evaluation is required to exclude diseases that mimic these disorders and to diagnose potential associated infectious, inflammatory, and neoplastic processes. Read More

    Modified Healthy Eating Index and Incidence of Metabolic Syndrome in Children and Adolescents: Tehran Lipid and Glucose Study.
    J Pediatr 2018 Apr 6. Epub 2018 Apr 6.
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Objective: To assess the relationship between modified healthy eating index (mHEI) with the development of metabolic syndrome (MetS) among children and adolescents.

    Study Design: Dietary data were collected using a food frequency questionnaire among 424 healthy subjects, aged 6-18 years. The components of mHEI were grains, vegetables and fruits, dairy, red to white meat ratio, butter, sweet snacks, sweetened beverages, salty snacks, and fast food. Read More

    Myelodysplastic Syndrome and Sweet's Syndrome Are Associated with a Mutation in Isocitrate Dehydrogenase 1.
    Anticancer Res 2018 04;38(4):2201-2205
    Department of Hemato-Oncology, Albert Einstein College of Medicine, Bronx, NY, U.S.A.
    Background: Sweet's syndrome (SS) is a febrile neutrophilic dermatosis that has been clinically linked to hematological malignancies, particularly myelodysplastic syndrome (MDS), in a number of case series. Many epigenetic changes underlying MDS have been identified, such as a mutation in the isocitrate dehydrogenase 1 (IDH1) gene, which causes DNA hypermethylation and alteration of a number of genes that lead to leukemogenesis. However, the pathogenesis of malignancy-associated SS is unknown. Read More

    Chorea revealing systemic lupus erythematosus in a 13-year old boy: A case report and short review of the literature.
    Int Rev Immunol 2018 Mar 29:1-6. Epub 2018 Mar 29.
    a Department of Paediatrics , Venizeleion General Hospital , Heraklion, Crete , Greece.
    Among the neurological manifestations of systemic lupus erythematosus (SLE), chorea is rare, presenting in less than 7% of the pediatric SLE patients. It can appear early in the onset of SLE, be the first or even the sole clinical feature of the illness and has strongly been associated with the presence of antiphospholipid antibodies. We report on the case of a 13-year old boy, admitted with acute onset chorea and finally diagnosed with SLE. Read More

    The role of vascular laboratory in the management of Eagle syndrome.
    J Vasc Surg Cases Innov Tech 2018 Mar 24;4(1):41-44. Epub 2018 Feb 24.
    Division of Vascular Surgery, University of Washington, Seattle, Wash.
    Eagle syndrome is caused by an elongated styloid process or calcified stylohyoid ligament. The stylocarotid variant with neurologic symptoms is rare and presents a diagnostic challenge. Patients may present with transient ischemic attacks, syncope, or less well defined symptoms like episodic dizziness. Read More

    Genetic Infiltrative Cardiomyopathies.
    Heart Fail Clin 2018 Apr;14(2):215-224
    Adult Medical Genetics Program, Cardiovascular Institute, University of Colorado Anschutz, 12700 East 19th Avenue, Aurora, CO 80045, USA. Electronic address:
    Infiltrative cardiomyopathies are characterized by abnormal accumulation or deposition of substances in cardiac tissue leading to cardiac dysfunction. These can be inherited, resulting from mutations in specific genes, which engender a diverse array of extracardiac features but overlapping cardiac phenotypes. This article provides an overview of each inherited infiltrative cardiomyopathy, describing the causative genes, the pathologic mechanisms involved, the resulting cardiac manifestations, and the therapies currently offered or being developed. Read More

    Sweet syndrome as the leading symptom in the diagnosis of gastric cancer.
    Chin Clin Oncol 2018 Feb;7(1):11
    Medical Oncology Department, Consorcio Hospital General Universitario de Valencia, Valencia, Spain; CIBERONC, Valencia, Spain.
    Sweet syndrome is a neutrophilic infiltration of the papillary dermis, which may be associated with the presence of unknown malignancies, either haematological or solid tumours, in 1 out of 5 cases, being considered then as a paraneoplastic syndrome. We present the case of a male with a locally advanced gastric cancer whose final diagnosis was led by the prior debut of Sweet syndrome not explained by other causes. Read More

    Sweet's Syndrome (SS) in the Course of Acute Myeloid Leukaemia (AML).
    Open Access Maced J Med Sci 2018 Jan 13;6(1):105-107. Epub 2018 Jan 13.
    Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR-Sofia), General Skobelev 79, 1606 Sofia, Bulgaria.
    Firstly described by Robert Douglas Sweet in 1964, febrile neutrophilic dermatosis is a disabling, not only cutaneous disorder, clinically characterised by fever and painful erythematous nodules, with a typical background of neutrophilia. Sweet's syndrome (SS) is a chronic inflammatory reactive disorder of unknown cause and incompletely established pathogenesis, although an interplay between genetic and environmental factors, including infections, is likely to occur. A significant part of cases has been demonstrated to be linked with malignancies, especially in the hematologic setting. Read More

    Association of Lifestyle Risk Factors with Metabolic Syndrome Components: A Cross-sectional Study in Eastern India.
    Int J Prev Med 2018 29;9. Epub 2018 Jan 29.
    Department of Cardiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
    Background: Approximately 20%-25% of the world adult population and nearly 30% of Indians have metabolic syndrome disorder. Our objective was designed to find out the association between important nutrients and potential lifestyle risk factors such as diet, physical inactivity, and smoking and alcohol consumption with the number of metabolic syndrome components.

    Methods: This was a cross-sectional study. Read More

    Feeding Infants with Neonatal Abstinence Syndrome: Finding the Sweet Spot.
    Neonatal Netw 2018 Jan;37(1):11-18
    University of South Florida, Tampa, FL 33620, USA, Email:
    Purpose: The purpose of this study is to learn how caregivers who are expert in feeding infants with neonatal abstinence syndrome (NAS) successfully feed these infants during withdrawal.

    Design/sample: Focus group methodology was used to gather information from self-identified experts from three large regional NICUs. Twelve NICU nurses and speech therapists participated in open-ended, recorded discussions. Read More

    Dietary patterns and physical activity in the metabolically (un)healthy obese: the Dutch Lifelines cohort study.
    Nutr J 2018 Feb 12;17(1):18. Epub 2018 Feb 12.
    Department of Endocrinology, University of Groningen, University Medical Center Groningen, HPC AA31, P.O. Box 30001, 9700, RB, Groningen, The Netherlands.
    Background: Diversity in the reported prevalence of metabolically healthy obesity (MHO), suggests that modifiable factors may be at play. We evaluated differences in dietary patterns and physical activity between MHO and metabolically unhealthy obesity (MUO).

    Methods: Cross-sectional data of 9270 obese individuals (30-69 years) of the Lifelines Cohort Study was used. Read More

    Neutrophilic dermatoses: a broad spectrum of disease.
    G Ital Dermatol Venereol 2018 Apr 24;153(2):265-272. Epub 2018 Jan 24.
    Unit of Dermatology, Carlo Urbai Hospital, AREA Vasta 2 ASUR Marche, Jesi, Ancona, Italy -
    The neutrophilic dermatoses (NDs) comprise a group of heterogeneous disorders characterized by inflammatory skin lesions that histologically show an intense inflammatory infiltrate composed primarily by neutrophils, with no evidence of infection or vasculitis. Although there are distinct clinical differences in the classical lesions of these disorders, many patients have overlapping features. In this review, we describe the clinical aspects of the main NDs, including: Sweet Syndrome, ND of the dorsal hands, pyoderma gangrenosum, erythema elevatum diutinum, subcorneal pustular dermatosis, neutrophilic eccrine hidradenitis, rheumatoid neutrophilic dermatitis, neutrophilic panniculitis, and aseptic abscesses including their association with underlying diseases and the differential diagnoses. Read More

    Sweet syndrome-like cutaneous drug reaction.
    An Bras Dermatol 2017 Nov-Dec;92(6):858-860
    Department of Dermatology, Complexo Hospitalar Padre Bento de Guarulhos (CHPBG) - Guarulhos (SP), Brazil.
    Cutaneous drug reactions are adverse reactions to medications that may present with different clinical features, ranging from localized to generalized lesions. In this report we describe a case of an unusual drug reaction, resembling the morphology of Sweet syndrome lesions. The patient had a psychiatric illness and was using thioridazine hydrochloride for one year. Read More

    Neuro-Ophthalmic Presentation of Neuro-Sweet Disease.
    Neuroophthalmology 2017 Aug 15;41(4):202-206. Epub 2017 Mar 15.
    Department of Neurological Sciences and Stanley Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA.
    Acute febrile neutrophilic dermatosis (Sweet syndrome) is a systemic inflammatory condition usually associated with autoimmune or neoplastic processes and characterised by inflammatory dermatologic lesions such as erythematous plaques and papules associated with fever and leukocytosis. Neurological and ophthalmological involvement is rare. The authors describe an unusual case of Sweet syndrome associated with microscopic polyangiitis presenting with papilloedema, anterior uveitis, and skin rash. Read More

    Enteritis-associated Acute Febrile Neutrophilic Dermatosis with Acute Monoarthritis.
    Folia Med (Plovdiv) 2017 Dec;59(4):477-480
    22nd Department of Internal Medicine, General Hospital of Trikala, Thessaly, Greece.
    Febrile neutrofilic dermatosis is an uncommon entity with complex pathophysiology, usually secondary to an infection, a malignancy or an autoimmune disease. Extracutaneous manifestations of the disease are very rare as well. We report a patient with histologically confirmed acute febrile neutrophilic dermatosis caused by viral enteritis that was presented with painful rash along with acute monoarthritis and treated with oral corticosteroids. Read More

    Cutaneous hemophagocytosis: Clinicopathologic features of 21 cases.
    J Am Acad Dermatol 2018 Feb;78(2):377-382
    Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria. Electronic address:
    Background: Hemophagocytosis is well known in cytotoxic cutaneous T-cell lymphomas (CTCLs), in which it may represent a sign of hemophagocytic lymphohistiocytosis syndrome (HLHS), and is also typical of cutaneous Rosai-Dorfman disease (cRDD) (without prognostic relevance). Only rarely, has cutaneous hemophagocytosis (CH) been described in other skin conditions.

    Objective: To characterize the clinicopathologic features of CH in skin biopsy specimens from patients with conditions other than CTCL or cRDD. Read More

    An extremely rare association of Sweet's syndrome with active pulmonary tuberculosis.
    Indian J Tuberc 2018 Jan 19;65(1):87-90. Epub 2017 May 19.
    Indira Gandhi Medical College (IGMC) Shimla, HP, Department of Dermatology, Venereology and Leprosy, Shimla, Himachal Pradesh 171001, India. Electronic address:
    Sweet's syndrome is a skin manifestation of various systemic infections, drugs, malignancies and autoimmune disorders. There are very few case reports describing the relationship between Sweet's syndrome and non-tubercular mycobacterium infection. Further development of Sweet's syndrome secondary to mycobacterium tuberculosis (active pulmonary tuberculosis) is extremely uncommon and this is the second well established case reported from India. Read More

    Potassium iodide in refractory, recurrent pediatric Sweet syndrome: Guidance in dosing and monitoring.
    Pediatr Dermatol 2018 Mar 4;35(2):271-273. Epub 2018 Jan 4.
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
    We describe a 5-month-old boy with clinical and histopathologic presentation of Sweet syndrome. He responded to systemic corticosteroids, with multiple flares on tapering; potassium iodide was added, which provided complete resolution of Sweet syndrome. Potassium iodide has been used in only a few cases, and no standard dosage has been established in children. Read More

    Role of Endocannabinoids on Sweet Taste Perception, Food Preference, and Obesity-related Disorders.
    Chem Senses 2017 Dec;43(1):3-16
    Department of Nutrition, Food Sciences and Gastronomy, Institute of Nutrition and Food Safety, University of Barcelona, Spain.
    The prevalence of obesity and obesity-related disorders such as type 2 diabetes (T2D) and metabolic syndrome has increased significantly in the past decades, reaching epidemic levels and therefore becoming a major health issue worldwide. Chronic overeating of highly palatable foods is one of the main responsible aspects behind overweight. Food choice is driven by food preference, which is influenced by environmental and internal factors, from availability to rewarding properties of food. Read More

    Expression of Elafin in Dermatitis Herpetiformis.
    Am J Dermatopathol 2018 Jan;40(1):1-6
    Professor of Dermatology and Dermatopathology, Department of Dermatology, University of Miami, University of Florida, Nova Southeastern University, FL.
    Background: Elafin is a serine protease inhibitor that has various epithelial cell regulatory and immunomodulatory effects including inactivation of neutrophil elastases. This later role originated the interest of elafin in certain neutrophil-rich dermatoses. Interestingly, it has been speculated that elafin has a protective role by slowing the deamidation process of gliadin in celiac disease (CD), despite the typical absence of neutrophils in intestinal histologic samplings. Read More

    Lymphocytes in Sweet syndrome: A potential diagnostic pitfall.
    J Cutan Pathol 2018 Mar 23;45(3):217-222. Epub 2018 Jan 23.
    Ackerman Academy of Dermatopathology, New York, New York.
    Background: Patients with Sweet syndrome (SS) have acute onset of cutaneous lesions with characteristic histopathology (dense and diffuse neutrophilic infiltrate, dermal edema, leukocytoclasis and no vasculitis) accompanied by systemic symptoms. Sometimes, only skin lesions with classic histopathologic features are seen. Although SS is considered to be a "neutrophilic dermatosis," lymphocytes are also seen on histological examination. Read More

    Genetic disorder in carbohydrates metabolism: hereditary fructose intolerance associated with celiac disease.
    Rom J Morphol Embryol 2017 ;58(3):1109-1113
    Emergency Department, "Grigore Alexandrescu" Emergency Hospital for Children, Bucharest, Romania;
    Celiac disease (CD) has been associated with several genetic and immune disorders, but association between CD and hereditary fructose intolerance (HFI) is extremely rare. HFI is an autosomal recessive disease caused by catalytic deficiency of aldolase B (fructose-1,6-bisphosphate aldolase). We report the case of a 5-year-old boy suffering from CD, admitted with an initial diagnosis of Reye's-like syndrome. Read More

    Successful Treatment of Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Neuro-Sweet Disease in Myelodysplastic Syndrome.
    Intern Med 2018 Feb 8;57(4):595-600. Epub 2017 Dec 8.
    Division of Hematology, Japanese Red Cross Society Wakayama Medical Center, Japan.
    Sweet disease may occur in several organs, and central nervous system involvement, known as Neuro-Sweet disease (NSD), is rare. The clinical features of NSD include recurrent encephalomeningitis accompanied by fever and erythematous plaques; systemic corticosteroid therapy is highly effective. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is an important electrolyte abnormality because it can be life-threatening. Read More

    Dietary Patterns and Metabolic Syndrome among Type 2 Diabetes Patients in Gaza Strip, Palestine.
    Ethiop J Health Sci 2017 May;27(3):227-238
    Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, International Campus (TUMS-IC), Tehran, Iran.
    Background: The prevalence of metabolic syndrome is raising worldwide; however, the role of diet in the origin of metabolic syndrome is not understood well. This study identifies major dietary patterns among type 2 diabetes mellitus patients with and without metabolic syndrome; and its association with metabolic syndrome components in Gaza Strip, Palestine.

    Methods: This cross sectional study was conducted among 1200 previously diagnosed type 2 diabetes mellitus (both genders, aged 20 - 64 years) patients receiving care in primary healthcare centers in Gaza Strip, Palestine. Read More

    A Pilot Study of Responses to Suctioning Among Neonates on Bubble Nasal Continuous Positive Airway Pressure.
    Adv Neonatal Care 2017 Dec;17(6):E3-E11
    Newborn Intensive Care Unit, Nationwide Children's Hospital at The Ohio State University Wexner Medical Center, Columbus (Mss Sweet, Bainbridge, and Reiner and Drs Armbruster and Chipps); and College of Nursing, The Ohio State University, Columbus (Drs Tan and Chipps).
    Background: Maintenance of a patent airway while the neonate is on nasal continuous positive airway pressure (nasal CPAP) requires vigilant monitoring and oral/nasopharyngeal suctioning. Currently, no evidence-based guidelines for safe suctioning in neonates while on bubble nasal CPAP have been published.

    Purpose: (1) To characterize the clinical and behavioral responses of neonates on bubble nasal CPAP in a level III neonatal intensive care unit following routine oral and nasopharyngeal suctioning. Read More

    Recurrent Malignancy-Associated Atypical Neutrophilic Dermatosis With Noninfectious Shock.
    Am J Med Sci 2017 12 20;354(6):626-632. Epub 2016 Oct 20.
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:
    Sweet syndrome (SS) or acute febrile neutrophilic dermatosis presents with the sudden onset of fever, leukocytosis and tender, erythematous, edematous, well-demarcated papules and plaques that histopathologically demonstrate a dense neutrophilic infiltrate. A total of 20% of patients with SS have malignancy-associated disease that can present with bullous or atypical skin lesions that mimic pyoderma gangrenosum, another neutrophilic dermatosis. Both entities exist on a spectrum, and in the context of underlying malignancy, these neutrophilic diseases become less clinically distinct. Read More

    Neutrophilic dermatoses: Kids are not just little people.
    Clin Dermatol 2017 Nov - Dec;35(6):541-554. Epub 2017 Aug 3.
    Department of Dermatology, University of Connecticut Health Center, Farmington, CT. Electronic address:
    Neutrophilic dermatoses are a group of inflammatory skin disorders characterized by an overactive innate immune system with dysregulation of neutrophils without underlying infectious etiology. The major representative conditions discussed are Sweet syndrome; pyoderma gangrenosum; neutrophilic eccrine hidradenitis; palmoplantar eccrine hidradenitis; subcorneal pustular dermatoses; bowel-associated dermatosis arthritis syndrome; and synovitis, acne, pustulosis, hyperostosis, and osteitis. We will also discuss other neutrophilic conditions present almost exclusively in the pediatric population, including congenital erosive and vesicular dermatosis with reticulated supple scarring and the recently described group of autoinflammatory diseases. Read More

    Sweet syndrome induced by oral acetaminophen-codeine following repair of a facial fracture.
    Cutis 2017 Sep;100(3):E20-E23
    Department of Dermatology, Howard University Hospital, Washington, DC, USA.
    Sweet syndrome (SS), also known as acute febrile neutrophilic dermatosis, is an uncommon condition that is clinically characterized by painful, well-demarcated, indurated, erythematous plaques or nodules that typically favor the head, neck, and arms, and are accompanied by fever. The disease is divided into several categories based on the underlying etiology, with the drug-induced variant comprising a rising number of the total cases and being reported in association with an increasing number of medications. We report a rare case of SS induced by an oral acetaminophen-codeine suspension and tablets. Read More

    Sweet syndrome in patients with and without malignancy: A retrospective analysis of 83 patients from a tertiary academic referral center.
    J Am Acad Dermatol 2018 Feb 26;78(2):303-309.e4. Epub 2017 Oct 26.
    Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
    Background: Sweet syndrome is a neutrophilic dermatosis that may be categorized into classic, malignancy-associated, and drug-induced subtypes. Few studies have systematically analyzed this rare disorder.

    Objective: To describe the clinicopathologic characteristics and treatment of Sweet syndrome and identify characteristics associated with concurrent malignancy. Read More

    [Medication rules of famous veteran traditional Chinese medicine doctor in treatment of chronic bronchitis based on implicit structure model].
    Zhongguo Zhong Yao Za Zhi 2017 Apr;42(8):1609-1616
    Henan Provincial Synergistic Innovation Center for Respiratory Disease Diagnosis and Treatment and New Drug Research and Development, Henan University of Chinese Medicine, Zhengzhou 450046, China.
    To explore the medication rules of famous veteran traditional Chinese medicine (TCM) doctors in treatment of chronic bronchitis, a structured medical record database for famous veteran TCM doctors in modern clinical books was established. First, Lantern 3.1. Read More

    Strange case of dimorphic skin rash in a patient with cirrhosis: atypical herpes simplex and sweet's syndrome.
    BMJ Case Rep 2017 Oct 20;2017. Epub 2017 Oct 20.
    Department of Gastroenterology, PVS Memorial Hospital, Cochin, Kerala, India.
    A middle-aged man with decompensated cirrhosis and a dimorphic multisite skin rash is diagnosed with rare atypical herpes simplex infection, manifesting Sweet's syndrome (SS) in the absence of other described associations. SS, an acute febrile neutrophilic dermatosis, has three common forms-classical or idiopathic, malignancy associated and drug induced. Systemic autoimmune, connective tissue diseases and infections are also strong associations. Read More

    Addressing the problem of obesity and associated cardiometabolic risk in black South African women - time for action!
    Glob Health Action 2017 ;10(1):1366165
    a Non-Communicable Disease Research Unit , South African Medical Research Council , Cape Town , South Africa.
    The PhD thesis of Gradidge, entitled 'Factors associated with obesity and metabolic syndrome in an ageing cohort of black women living in Soweto, Johannesburg (Study of Women in and Entering Endocrine Transition [SWEET])', attempts to understand the determinants of obesity and metabolic syndrome (MetS) in a population of urban-dwelling black South African women. A conceptual framework is presented, which positions obesity as the central risk factor for MetS, and includes the possible influence of socioeconomic status, lifestyle behaviours and body size perceptions, as key determinants of obesity. This commentary focuses on the two main findings of Gradidge's thesis, namely, (i) physical activity and sedentary behaviour, and (ii) body composition and adiponectin, as risk factors for obesity and MetS in black South African women. Read More

    An interesting case of pyoderma gangrenosum with immature hystiocytoid neutrophils.
    J Cutan Pathol 2018 Jan 8;45(1):63-66. Epub 2017 Nov 8.
    Department of Pathology, Notre-Dame Hospital, University of Montreal, Montreal, Quebec, Canada.
    We present a unique case of a 36-year-old male who developed more than 20 pyoderma gangrenosum (PG) ulcers showing on histopathology a dense inflammatory infiltrate composed of histiocytoid mononuclear immature cells with a strong positivity for myeloperoxidase and Leder stain, suggesting a myeloid lineage in the absence of a concomitant myeloproliferative disorder. Histiocytoid Sweet syndrome (SS) is now recognized as a histological subtype of SS. Although PG and SS belong to the spectrum of neutrophilic diseases, to the best of our knowledge, this is the first case of a "Histiocytoid pyoderma gangrenosum" encompassing immature granulocytes in the absence of leukemia cutis. Read More

    Activation of the sweet taste receptor, T1R3, by the artificial sweetener sucralose regulates the pulmonary endothelium.
    Am J Physiol Lung Cell Mol Physiol 2018 01 28;314(1):L165-L176. Epub 2017 Sep 28.
    Biomedical Research Group, Anglia Ruskin University , Cambridge , United Kingdom.
    A hallmark of acute respiratory distress syndrome (ARDS) is pulmonary vascular permeability. In these settings, loss of barrier integrity is mediated by cell-contact disassembly and actin remodeling. Studies into molecular mechanisms responsible for improving microvascular barrier function are therefore vital in the development of therapeutic targets for reducing vascular permeability in ARDS. Read More

    Assessment of Safety, Tolerability, Pharmacokinetics, and Pharmacological Effect of Orally Administered CORT125134: An Adaptive, Double-Blind, Randomized, Placebo-Controlled Phase 1 Clinical Study.
    Clin Pharmacol Drug Dev 2018 May 2;7(4):408-421. Epub 2017 Oct 2.
    Corcept Therapeutics, Menlo Park, CA, USA.
    CORT125134 is an orally active, high-affinity, selective antagonist of the glucocorticoid receptor that is being developed for indications that may benefit from the modulation of cortisol activity. This first-in-human study was conducted to evaluate the dose-related safety, tolerability, pharmacokinetics and pharmacological effects of CORT125134 and its active metabolite CORT125201. Eighty-one healthy male or female subjects received a single dose of 5 to 500 mg CORT125134 or matching placebo across 9 cohorts; 1 cohort received 150 mg CORT125134 after a high-fat breakfast; and 46 subjects received 50 to 500 mg CORT125134 or matching placebo once daily for up to 14 days across 4 cohorts. Read More

    Histiocytoid Sweet Syndrome in a Child without Underlying Systemic Disease.
    Ann Dermatol 2017 Oct 25;29(5):626-629. Epub 2017 Aug 25.
    Department of Dermatology, Inha University School of Medicine, Incheon, Korea.
    Sweet syndrome (acute, febrile, neutrophilic dermatosis) is characterized by the acute onset of an eruption of painful nodules or erythematous or violaceous plaques on the limbs, face and neck. These symptoms are accompanied by fever. The diagnostic features include histopathological findings of dermal neutrophilic infiltration without leukocytoclastic vasculitis or peripheral blood leukocytosis. Read More

    Sweet syndrome caused by sensitization to gabapentin.
    J Allergy Clin Immunol Pract 2018 Mar - Apr;6(2):685-686. Epub 2017 Sep 22.
    Allergy Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Gregorio Marañón Health Research Institute (IiSGM), Madrid, Spain; Biomedical Research Network on Rare Diseases (CIBERER)-U761, Madrid, Spain.

    A rare case report describing the relation between sweet syndrome and spontaneous recurrent peritonitis.
    Int J Surg Case Rep 2017 21;39:93-97. Epub 2017 Jul 21.
    Gloucestershire Hospitals NHS Foundation Trust, UK.
    Introduction: Sweet syndrome (acute febrile neutrophilic dermatosis) is a subset of rare inflammatory disorders, first described by Dr. Robert Douglas Sweet in 1964 (Sweet, 1964). The co-existence of Sweet syndrome and spontaneous recurrent peritonitis has never been previously mentioned in the medical literature. Read More

    Neutrophilic Dermatosis of the Hands: A Review of 17 Cases.
    J Hand Surg Am 2018 Feb 21;43(2):185.e1-185.e5. Epub 2017 Sep 21.
    Department of Hand Surgery and Peripheral Nerve Surgery, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia. Electronic address:
    Purpose: Neutrophilic dermatosis of the hands is an inflammatory skin condition related to Sweet syndrome that responds to corticosteroids. It commonly affects the dorsum of the hand and often mimics infection, with violaceous inflammatory papules and plaques that may ulcerate. The aim of this study was to review the clinical presentation of neutrophilic dermatosis of the hands. Read More

    Necrotizing Sweet Syndrome of the Upper Extremity After Elective Hand Surgery.
    J Hand Surg Am 2018 Apr 19;43(4):389.e1-389.e6. Epub 2017 Sep 19.
    Department of Orthopaedic Surgery, University of Rochester Medical Center, Rochester, NY. Electronic address:
    Sweet syndrome, or acute febrile neutrophilic dermatosis, is a systemic disease process mainly characterized by hyperpyrexia and skin lesions. A newly described entity, necrotizing Sweet syndrome, is a severe and locally aggressive dermatological condition that clinically and histopathologically resembles a necrotizing soft tissue infection. It is characterized by pathergy, a nonspecific inflammatory response to cutaneous trauma resulting in a propagation of the disease. Read More

    Development of hepatocellular cancer induced by long term low fat-high carbohydrate diet in a NAFLD/NASH mouse model.
    Oncotarget 2017 Aug 21;8(32):53482-53494. Epub 2017 Jun 21.
    Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
    Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease. It can progress to nonalcoholic steatohepatitis (NASH) and, in a percentage of cases, to hepatocarcinogenesis. The strong incidence in western countries of obesity and metabolic syndrome, whose NAFLD is the hepatic expression, is thought to be correlated to consumption of diets characterized by processed food and sweet beverages. Read More

    Sweet's syndrome: a clinical entity need to discriminate against acute haematogenous periprosthetic joint infection.
    Knee Surg Sports Traumatol Arthrosc 2017 Sep 5. Epub 2017 Sep 5.
    Department of Orthopaedics Surgery, Chonbuk National University Medical School, Research Institute for Endocrine Sciences, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, 567 Baekje-ro, Dukjin-gu, Jeonju, 561-756, Republic of Korea.
    Sweet's syndrome (SS) or acute febrile neutrophilic dermatosis is an uncommon condition. It is characterized by fever, polymorphonuclear leukocytosis, painful erythematous cutaneous plaques, and dense dermal infiltrate of neutrophils without vasculitis at the site of skin lesions. Lesions in SS might enlarge and coalesce with increasing dermal oedema, resulting in pseudo-vesicular appearance mimicking joint infections. Read More

    Retro- and orthonasal olfactory function in relation to olfactory bulb volume in patients with hypogonadotrophic hypogonadism.
    Braz J Otorhinolaryngol 2017 Aug 24. Epub 2017 Aug 24.
    Interdisciplinary Center "Smell & Taste", Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.
    Introduction: Idiopathic hypogonadotrophic hypogonadism (IHH) with an olfactory deficit is defined as Kallmann syndrome (KS) and is distinct from normosmic IHH.

    Objective: Because olfactory perception not only consists of orthonasally gained impressions but also involves retronasal olfactory function, in this study we decided to comprehensively evaluate both retronasal and orthonasal olfaction in patients with IHH.

    Methods: This case-control study included 31 controls and 45 IHH patients. Read More

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