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    1995 results match your criteria Acute Febrile Neutrophilic Dermatosis

    1 OF 40

    Successful Treatment of Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Neuro-Sweet Disease in Myelodysplastic Syndrome.
    Intern Med 2017 Dec 8. Epub 2017 Dec 8.
    Division of Hematology, Japanese Red Cross Society Wakayama Medical Center, Japan.
    Sweet disease may occur in several organs, and central nervous system involvement, known as Neuro-Sweet disease (NSD), is rare. The clinical features of NSD include recurrent encephalomeningitis accompanied by fever and erythematous plaques; systemic corticosteroid therapy is highly effective. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is an important electrolyte abnormality because it can be life-threatening. Read More

    Dietary Patterns and Metabolic Syndrome among Type 2 Diabetes Patients in Gaza Strip, Palestine.
    Ethiop J Health Sci 2017 May;27(3):227-238
    Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, International Campus (TUMS-IC), Tehran, Iran.
    Background: The prevalence of metabolic syndrome is raising worldwide; however, the role of diet in the origin of metabolic syndrome is not understood well. This study identifies major dietary patterns among type 2 diabetes mellitus patients with and without metabolic syndrome; and its association with metabolic syndrome components in Gaza Strip, Palestine.

    Methods: This cross sectional study was conducted among 1200 previously diagnosed type 2 diabetes mellitus (both genders, aged 20 - 64 years) patients receiving care in primary healthcare centers in Gaza Strip, Palestine. Read More

    Recurrent Malignancy-Associated Atypical Neutrophilic Dermatosis With Noninfectious Shock.
    Am J Med Sci 2017 Dec 20;354(6):626-632. Epub 2016 Oct 20.
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:
    Sweet syndrome (SS) or acute febrile neutrophilic dermatosis presents with the sudden onset of fever, leukocytosis and tender, erythematous, edematous, well-demarcated papules and plaques that histopathologically demonstrate a dense neutrophilic infiltrate. A total of 20% of patients with SS have malignancy-associated disease that can present with bullous or atypical skin lesions that mimic pyoderma gangrenosum, another neutrophilic dermatosis. Both entities exist on a spectrum, and in the context of underlying malignancy, these neutrophilic diseases become less clinically distinct. Read More

    Neutrophilic dermatoses: Kids are not just little people.
    Clin Dermatol 2017 Nov - Dec;35(6):541-554. Epub 2017 Aug 3.
    Department of Dermatology, University of Connecticut Health Center, Farmington, CT. Electronic address:
    Neutrophilic dermatoses are a group of inflammatory skin disorders characterized by an overactive innate immune system with dysregulation of neutrophils without underlying infectious etiology. The major representative conditions discussed are Sweet syndrome; pyoderma gangrenosum; neutrophilic eccrine hidradenitis; palmoplantar eccrine hidradenitis; subcorneal pustular dermatoses; bowel-associated dermatosis arthritis syndrome; and synovitis, acne, pustulosis, hyperostosis, and osteitis. We will also discuss other neutrophilic conditions present almost exclusively in the pediatric population, including congenital erosive and vesicular dermatosis with reticulated supple scarring and the recently described group of autoinflammatory diseases. Read More

    Sweet syndrome induced by oral acetaminophen-codeine following repair of a facial fracture.
    Cutis 2017 Sep;100(3):E20-E23
    Department of Dermatology, Howard University Hospital, Washington, DC, USA.
    Sweet syndrome (SS), also known as acute febrile neutrophilic dermatosis, is an uncommon condition that is clinically characterized by painful, well-demarcated, indurated, erythematous plaques or nodules that typically favor the head, neck, and arms, and are accompanied by fever. The disease is divided into several categories based on the underlying etiology, with the drug-induced variant comprising a rising number of the total cases and being reported in association with an increasing number of medications. We report a rare case of SS induced by an oral acetaminophen-codeine suspension and tablets. Read More

    Sweet syndrome in patients with and without malignancy: A retrospective analysis of 83 patients from a tertiary academic referral center.
    J Am Acad Dermatol 2017 Oct 26. Epub 2017 Oct 26.
    Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
    Background: Sweet syndrome is a neutrophilic dermatosis that may be categorized into classic, malignancy-associated, and drug-induced subtypes. Few studies have systematically analyzed this rare disorder.

    Objective: To describe the clinicopathologic characteristics and treatment of Sweet syndrome and identify characteristics associated with concurrent malignancy. Read More

    [Medication rules of famous veteran traditional Chinese medicine doctor in treatment of chronic bronchitis based on implicit structure model].
    Zhongguo Zhong Yao Za Zhi 2017 Apr;42(8):1609-1616
    Henan Provincial Synergistic Innovation Center for Respiratory Disease Diagnosis and Treatment and New Drug Research and Development, Henan University of Chinese Medicine, Zhengzhou 450046, China.
    To explore the medication rules of famous veteran traditional Chinese medicine (TCM) doctors in treatment of chronic bronchitis, a structured medical record database for famous veteran TCM doctors in modern clinical books was established. First, Lantern 3.1. Read More

    Strange case of dimorphic skin rash in a patient with cirrhosis: atypical herpes simplex and sweet's syndrome.
    BMJ Case Rep 2017 Oct 20;2017. Epub 2017 Oct 20.
    Department of Gastroenterology, PVS Memorial Hospital, Cochin, Kerala, India.
    A middle-aged man with decompensated cirrhosis and a dimorphic multisite skin rash is diagnosed with rare atypical herpes simplex infection, manifesting Sweet's syndrome (SS) in the absence of other described associations. SS, an acute febrile neutrophilic dermatosis, has three common forms-classical or idiopathic, malignancy associated and drug induced. Systemic autoimmune, connective tissue diseases and infections are also strong associations. Read More

    Addressing the problem of obesity and associated cardiometabolic risk in black South African women - time for action!
    Glob Health Action 2017 ;10(1):1366165
    a Non-Communicable Disease Research Unit , South African Medical Research Council , Cape Town , South Africa.
    The PhD thesis of Gradidge, entitled 'Factors associated with obesity and metabolic syndrome in an ageing cohort of black women living in Soweto, Johannesburg (Study of Women in and Entering Endocrine Transition [SWEET])', attempts to understand the determinants of obesity and metabolic syndrome (MetS) in a population of urban-dwelling black South African women. A conceptual framework is presented, which positions obesity as the central risk factor for MetS, and includes the possible influence of socioeconomic status, lifestyle behaviours and body size perceptions, as key determinants of obesity. This commentary focuses on the two main findings of Gradidge's thesis, namely, (i) physical activity and sedentary behaviour, and (ii) body composition and adiponectin, as risk factors for obesity and MetS in black South African women. Read More

    An interesting case of pyoderma gangrenosum with immature hystiocytoid neutrophils.
    J Cutan Pathol 2017 Oct 5. Epub 2017 Oct 5.
    Department of Pathology, Notre-Dame Hospital, University of Montreal, Montreal, Quebec, Canada.
    We present a unique case of a 36-year-old male who developed more than 20 pyoderma gangrenosum (PG) ulcers showing on histopathology a dense inflammatory infiltrate composed of histiocytoid mononuclear immature cells with a strong positivity for myeloperoxidase and Leder stain, suggesting a myeloid lineage in the absence of a concomitant myeloproliferative disorder. Histiocytoid Sweet syndrome (SS) is now recognized as a histological subtype of SS. Although PG and SS belong to the spectrum of neutrophilic diseases, to the best of our knowledge, this is the first case of a "Histiocytoid pyoderma gangrenosum" encompassing immature granulocytes in the absence of leukemia cutis. Read More

    Activation of the sweet taste receptor, T1R3, by the artificial sweetener sucralose regulates the pulmonary endothelium.
    Am J Physiol Lung Cell Mol Physiol 2017 Sep 28:ajplung.00490.2016. Epub 2017 Sep 28.
    Anglia Ruskin University
    A hallmark of acute respiratory distress syndrome (ARDS) is pulmonary vascular permeability. In these settings, loss of barrier integrity is mediated by cell-contact disassembly and actin-remodelling. Studies into molecular mechanisms responsible for improving microvascular barrier function are therefore vital in the development of therapeutic targets for reducing vascular permeability in ARDS. Read More

    Assessment of Safety, Tolerability, Pharmacokinetics, and Pharmacological Effect of Orally Administered CORT125134: An Adaptive, Double-Blind, Randomized, Placebo-Controlled Phase 1 Clinical Study.
    Clin Pharmacol Drug Dev 2017 Oct 2. Epub 2017 Oct 2.
    Corcept Therapeutics, Menlo Park, CA, USA.
    CORT125134 is an orally active, high-affinity, selective antagonist of the glucocorticoid receptor that is being developed for indications that may benefit from the modulation of cortisol activity. This first-in-human study was conducted to evaluate the dose-related safety, tolerability, pharmacokinetics and pharmacological effects of CORT125134 and its active metabolite CORT125201. Eighty-one healthy male or female subjects received a single dose of 5 to 500 mg CORT125134 or matching placebo across 9 cohorts; 1 cohort received 150 mg CORT125134 after a high-fat breakfast; and 46 subjects received 50 to 500 mg CORT125134 or matching placebo once daily for up to 14 days across 4 cohorts. Read More

    Histiocytoid Sweet Syndrome in a Child without Underlying Systemic Disease.
    Ann Dermatol 2017 Oct 25;29(5):626-629. Epub 2017 Aug 25.
    Department of Dermatology, Inha University School of Medicine, Incheon, Korea.
    Sweet syndrome (acute, febrile, neutrophilic dermatosis) is characterized by the acute onset of an eruption of painful nodules or erythematous or violaceous plaques on the limbs, face and neck. These symptoms are accompanied by fever. The diagnostic features include histopathological findings of dermal neutrophilic infiltration without leukocytoclastic vasculitis or peripheral blood leukocytosis. Read More

    Sweet syndrome caused by sensitization to gabapentin.
    J Allergy Clin Immunol Pract 2017 Sep 22. Epub 2017 Sep 22.
    Allergy Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Gregorio Marañón Health Research Institute (IiSGM), Madrid, Spain; Biomedical Research Network on Rare Diseases (CIBERER)-U761, Madrid, Spain.

    A rare case report describing the relation between sweet syndrome and spontaneous recurrent peritonitis.
    Int J Surg Case Rep 2017 21;39:93-97. Epub 2017 Jul 21.
    Gloucestershire Hospitals NHS Foundation Trust, UK.
    Introduction: Sweet syndrome (acute febrile neutrophilic dermatosis) is a subset of rare inflammatory disorders, first described by Dr. Robert Douglas Sweet in 1964 (Sweet, 1964). The co-existence of Sweet syndrome and spontaneous recurrent peritonitis has never been previously mentioned in the medical literature. Read More

    Neutrophilic Dermatosis of the Hands: A Review of 17 Cases.
    J Hand Surg Am 2017 Sep 21. Epub 2017 Sep 21.
    Department of Hand Surgery and Peripheral Nerve Surgery, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia. Electronic address:
    Purpose: Neutrophilic dermatosis of the hands is an inflammatory skin condition related to Sweet syndrome that responds to corticosteroids. It commonly affects the dorsum of the hand and often mimics infection, with violaceous inflammatory papules and plaques that may ulcerate. The aim of this study was to review the clinical presentation of neutrophilic dermatosis of the hands. Read More

    Necrotizing Sweet Syndrome of the Upper Extremity After Elective Hand Surgery.
    J Hand Surg Am 2017 Sep 19. Epub 2017 Sep 19.
    Department of Orthopaedic Surgery, University of Rochester Medical Center, Rochester, NY. Electronic address:
    Sweet syndrome, or acute febrile neutrophilic dermatosis, is a systemic disease process mainly characterized by hyperpyrexia and skin lesions. A newly described entity, necrotizing Sweet syndrome, is a severe and locally aggressive dermatological condition that clinically and histopathologically resembles a necrotizing soft tissue infection. It is characterized by pathergy, a nonspecific inflammatory response to cutaneous trauma resulting in a propagation of the disease. Read More

    Development of hepatocellular cancer induced by long term low fat-high carbohydrate diet in a NAFLD/NASH mouse model.
    Oncotarget 2017 Aug 21;8(32):53482-53494. Epub 2017 Jun 21.
    Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
    Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease. It can progress to nonalcoholic steatohepatitis (NASH) and, in a percentage of cases, to hepatocarcinogenesis. The strong incidence in western countries of obesity and metabolic syndrome, whose NAFLD is the hepatic expression, is thought to be correlated to consumption of diets characterized by processed food and sweet beverages. Read More

    Sweet's syndrome: a clinical entity need to discriminate against acute haematogenous periprosthetic joint infection.
    Knee Surg Sports Traumatol Arthrosc 2017 Sep 5. Epub 2017 Sep 5.
    Department of Orthopaedics Surgery, Chonbuk National University Medical School, Research Institute for Endocrine Sciences, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, 567 Baekje-ro, Dukjin-gu, Jeonju, 561-756, Republic of Korea.
    Sweet's syndrome (SS) or acute febrile neutrophilic dermatosis is an uncommon condition. It is characterized by fever, polymorphonuclear leukocytosis, painful erythematous cutaneous plaques, and dense dermal infiltrate of neutrophils without vasculitis at the site of skin lesions. Lesions in SS might enlarge and coalesce with increasing dermal oedema, resulting in pseudo-vesicular appearance mimicking joint infections. Read More

    Retro- and orthonasal olfactory function in relation to olfactory bulb volume in patients with hypogonadotrophic hypogonadism.
    Braz J Otorhinolaryngol 2017 Aug 24. Epub 2017 Aug 24.
    Interdisciplinary Center "Smell & Taste", Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.
    Introduction: Idiopathic hypogonadotrophic hypogonadism (IHH) with an olfactory deficit is defined as Kallmann syndrome (KS) and is distinct from normosmic IHH.

    Objective: Because olfactory perception not only consists of orthonasally gained impressions but also involves retronasal olfactory function, in this study we decided to comprehensively evaluate both retronasal and orthonasal olfaction in patients with IHH.

    Methods: This case-control study included 31 controls and 45 IHH patients. Read More

    Sweet's Syndrome Arising in a Scar.
    Case Rep Dermatol 2017 May-Aug;9(2):86-90. Epub 2017 Jul 13.
    Tripler Army Medical Center, Honolulu, Hawaii, USA.
    Acute febrile neutrophilic dermatosis (Sweet's syndrome) is an uncommon inflammatory cutaneous disorder. It presents with lesions which are tender, erythematous, edematous papules and under histologic examination show dense neutrophilic infiltration of the dermis. These lesions are often accompanied by leukocytosis and fever. Read More

    Distribution of glucose transporters in renal diseases.
    J Biomed Sci 2017 Aug 31;24(1):64. Epub 2017 Aug 31.
    Medical University of Warsaw, Chair & Department of General Biology & Parasitology, Center for Biostructure Research, 5 Chalubinskiego Str., 02-004, Warsaw, Poland.
    Kidneys play an important role in glucose homeostasis. Renal gluconeogenesis prevents hypoglycemia by releasing glucose into the blood stream. Glucose homeostasis is also due, in part, to reabsorption and excretion of hexose in the kidney. Read More

    Reduced brain response to a sweet taste in Hispanic young adults.
    Brain Res 2017 Nov 26;1674:101-110. Epub 2017 Aug 26.
    San Diego State University/UC San Diego Joint Doctoral Program, San Diego, CA, USA; San Diego State University, San Diego, CA, USA; University of California, San Diego, CA, USA. Electronic address:
    Hispanics have an increased risk for metabolic disorders, which evidence suggests may be due to interactions between lifespan biological, genetic, and lifestyle factors. Studies show the diet of many U.S. Read More

    A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean Fever.
    Ann Rheum Dis 2017 Dec 23;76(12):2085-2094. Epub 2017 Aug 23.
    Inflammation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
    Objective: Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis (PAAND) is a recently described monogenic autoinflammatory disease. The causal p.S242R MEFV mutation disrupts a binding motif of the regulatory 14-3-3 proteins within pyrin. Read More

    A Sweet Case of Mycoplasma.
    Pediatrics 2017 Sep 18;140(3). Epub 2017 Aug 18.
    Hasbro Children's Hospital, Warren Alpert Medical School at Brown University, Providence, Rhode Island.
    Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is an uncommon inflammatory disorder marked by fever and swelling of the skin that can be very painful. It is especially rare in the pediatric population. Infection is a well-known trigger for Sweet syndrome, but this entity has, to our knowledge, never been described after Mycoplasma infection. Read More

    Certain Dietary Habits Contribute to the Functional Dyspepsia in South China Rural Area.
    Med Sci Monit 2017 Aug 15;23:3942-3951. Epub 2017 Aug 15.
    Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China (mainland).
    BACKGROUND Functional dyspepsia (FD) refers to a group of upper gastrointestinal syndromes, subdivided into two types: postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). The etiology of FD remains unclear; however, unhealthy dietary habit is one potential underlying cause. We aim to explore the association of poor dietary habits with FD and its subtypes. Read More

    The Inhibitory Effects of Purple Sweet Potato Color on Hepatic Inflammation Is Associated with Restoration of NAD⁺ Levels and Attenuation of NLRP3 Inflammasome Activation in High-Fat-Diet-Treated Mice.
    Molecules 2017 Aug 8;22(8). Epub 2017 Aug 8.
    Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu Province, China.
    Purple sweet potato color (PSPC), a class of naturally occurring anthocyanins, exhibits beneficial effects on metabolic syndrome. Sustained inflammation plays a crucial role in the pathogenesis of metabolic syndrome. Here we explored the effects of PSPC on high-fat diet (HFD)-induced hepatic inflammation and the mechanisms underlying these effects. Read More

    Sweet's syndrome in a patient with chronic lymphocytic leukaemia.
    BMJ Case Rep 2017 Aug 7;2017. Epub 2017 Aug 7.
    Department of Dermatology, Royal Devon and Exeter Hospital, Exeter, Devon, UK.
    Bullous Sweet's syndrome is a rare variant of the inflammatory neutrophilic dermatosis characterised by painful bullous skin lesions, fever, leukocytosis and a neutrophilic infiltrate of the dermis. The condition may be classified according to aetiology into classical (idiopathic), malignancy-associated and drug-induced. Neutrophilic infiltration occurs in response to a systemic insult. Read More

    Drug management of neutrophilic dermatoses.
    Expert Rev Clin Pharmacol 2017 Oct 27;10(10):1119-1128. Epub 2017 Jul 27.
    b UOC Dermatologia, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti , Università Degli Studi di Milano , Milan , Italy.
    Introduction: Neutrophilic dermatoses are a heterogenous group of chronic, cutaneous inflammatory conditions characterized by the accumulation of neutrophils in the skin and by systemic inflammation. Neutrophilic dermatoses can be idiopathic or associated with other inflammatory or systemic diseases, including the group of the hereditary, autoinflammatory syndromes. Clinical management is challenging, due to limited clinical evidence and lack of clinical practice guidelines. Read More

    Myelodysplastic syndrome with neutrophilic dermatosis successfully treated with azacitidine.
    Rinsho Ketsueki 2017 ;58(6):607-612
    Department of Dermatology, Hitachi General Hospital.
    A 66-year-old male underwent prednisolone (PSL) therapy of 13 mg/day for rheumatoid arthritis (RA). Antiphospholipid antibody syndrome, neutrophilic dermatosis (ND), and myelodysplastic syndrome (MDS) developed. Treatment of MDS required red cell concentrate transfusion, and second courses of azacitidine therapy (75 mg/m2 daily, intravenous injection for 7 consecutive days) led to hematologic remission. Read More

    [Refractory Sweet syndrome complicated by monoclonal gammopathy of undetermined significance].
    Rev Med Brux 2017 ;38(3):152-153
    Service de Médecine interne B, Hôpital Charles-Nicolle, Tunis, Tunisie.
    The association between Sweet syndrome and monoclonal gammopathy of undetermined significance (MGUS) is exceptional. We report the case of a 44 years-old woman in whom recurrent Sweet syndrome was complicated by monoclonal gammopathy of undetermined significance (MGUS) after 3 years of evolution. Read More

    Sweet's Syndrome Successfully Treated with Granulocyte and Monocyte Adsorption Apheresis.
    Case Rep Dermatol 2017 May-Aug;9(2):13-18. Epub 2017 May 22.
    aDepartment of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
    Sweet's syndrome is a neutrophilic dermatosis characterized by an abrupt onset of painful erythematous lesions showing neutrophilic infiltrates in the dermis. Fever and an elevated neutrophil level are generally observed. Sweet's syndrome may be idiopathic, malignancy-associated, or drug-induced (mainly involving granulocyte colony-stimulating factor (G-CSF) administration). Read More

    Tumor Necrosis Factor-α and IL-17A Activation Induces Pericyte-Mediated Basement Membrane Remodeling in Human Neutrophilic Dermatoses.
    Am J Pathol 2017 Aug 10;187(8):1893-1906. Epub 2017 Jun 10.
    Department of Biomedical Engineering, Yale University, New Haven, Connecticut. Electronic address:
    Sweet syndrome (SS) is a prototypical neutrophilic dermatosis, a class of inflammatory diseases marked by elevated levels of tumor necrosis factor (TNF)-α and IL-17A, pathologic neutrophil recruitment, and microvascular remodeling. Histologic analyses of four matrix proteins-collagen I and IV, laminin, and fibronectin-in skin biopsies of patients with SS reveal that the basement membrane of dermal postcapillary venules undergoes changes in structure and composition. Increased neutrophil recruitment in vivo was associated with increases in collagen IV, decreases in laminin, and varied changes in fibronectin. Read More

    Effects of Radix Astragali and Its Split Components on Gene Expression Profiles Related to Water Metabolism in Rats with the Dampness Stagnancy due to Spleen Deficiency Syndrome.
    Evid Based Complement Alternat Med 2017 21;2017:4946031. Epub 2017 May 21.
    School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
    Radix Astragali (RA) with slight sweet and warm property is a significant "qi tonifying" herb; it is indicated for the syndrome of dampness stagnancy due to spleen deficiency (DSSD). The purpose of this research was to explore effects of RA and its split components on gene expression profiles related to water metabolism in rats with the DSSD syndrome for identifying components representing property and flavor of RA. The results indicated that RA and its split components, especially polysaccharides component, significantly increased the body weight and the urine volume and decreased the water load index of model rats. Read More

    Sweet Syndrome After Bilateral Deep Inferior Epigastric Perforator Flap Breast Reconstruction: A Case Report.
    Ann Plast Surg 2017 Nov;79(5):e30-e32
    From the Department of Surgery, Division of Plastic and Reconstructive Surgery, Icahn School of Medicine at Mount Sinai, New York, NY.
    We describe a case of Sweet's Syndrome after bilateral deep inferior epigastric perforator flap breast reconstruction in a patient with ductal carcinoma of the left breast. Read More

    Malignancy-associated Sweet syndrome: acute febrile neutrophilic dermatosis associated with recurrence of metastatic cervical cancer.
    Dermatol Online J 2017 04 15;23(4). Epub 2017 Apr 15.
    Department of Dermatology, University of California, Davis, Sacramento, California.
    We present a rare case of acute febrile neutrophilic dermatosis, also known as Sweet syndrome, associated with recurrence of metastatic cervical cancer. This report highlights similar reports and serves as an important reminder of the relationship between Sweet syndrome and cervical cancer. Increasing awareness of Sweet syndrome assists clinicians in recognizing characteristic findings and encourages evaluation of patients for new-onset or recurrent neoplastic disease. Read More

    Sweet's syndrome associated with Crohn's disease.
    An Bras Dermatol 2017 Mar-Apr;92(2):263-265
    Medical student of the Universidade do Estado do Pará (UEPA) - Belém (PA), Brazil.
    Sweet's syndrome is an uncommon benign skin disorder, whose pathogenesis remains unknown. Its classic form is more common in women and presents itself as papular-nodular, painful and erythematous or violaceous lesions. It mainly affects the face, neck, and upper limbs. Read More

    Sweet syndrome presenting as a febrile rash in a returning traveller.
    CJEM 2017 May 23:1-3. Epub 2017 May 23.
    ‡Department of Family and Community Medicine,Division of Emergency Medicine,University of Toronto,Toronto,ON.
    Sweet syndrome was discovered in 1964 and is now well described in the dermatology literature. Knowledge of this unique febrile and painful dermatosis is important for the emergency physician because the syndrome can be readily identified and is extremely responsive to oral steroid therapy. Early diagnosis can greatly improve patient satisfaction and avoid days of ineffective treatment. Read More

    The Pathergy Test as a Diagnostic Tool.
    Skinmed 2017 1;15(2):97-104. Epub 2017 Apr 1.
    Dermatology Unit, Kaplan Medical Center, Rechovot, Israel.
    The pathergy test produces a nonspecific hyperreactive lesion in Behçet's disease (BD), a finding that has been known since 1937. Pathergy refers to the development of new skin lesions or the aggravation of existing ones after trivial trauma. In clinical practice, the pathergy test induces a skin response by needleprick, with positive reactions manifesting as a papule or pustule developing by 48 hours. Read More

    T helper type 1-related molecules as well as interleukin-15 are hyperexpressed in the skin lesions of patients with pyoderma gangrenosum.
    Clin Exp Immunol 2017 Sep 23;189(3):383-391. Epub 2017 Jun 23.
    Department of Surgery and Translational Medicine, Section of Dermatology, University of Florence, Florence, Italy.
    Pyoderma gangrenosum (PG) is a rare, immune-mediated skin disease classified into the group of neutrophilic dermatoses. Although a number of studies confirmed the central role of innate immunity, only few studies have investigated the possible contributing role of acquired immunity. In particular, no reports concerning T helper type 1 (Th1) and Th2 cells are available as yet. Read More

    Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease.
    N Engl J Med 2017 05;376(20):1933-1942
    From the Cleveland Clinic Coordinating Center for Clinical Research (C5Research), Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland (A.M.L., V.M., E.M., K.W., D.M., S.E.N.); South Australian Heart and Medical Research Institute, University of Adelaide, Adelaide (S.J.N.), and School of Medical Sciences, University of New South Wales, Sydney (P.J.B.) - both in Australia; Eli Lilly, Indianapolis (J.S.R., G.R., B.V., G.W.); Washington Cardiovascular Associates, Medstar Research Institute, Washington, DC (H.B.B.); Centre for Cardiovascular Science, University of Edinburgh, Edinburgh (K.A.A.F.); Beth Israel Deaconess Medical Center, Boston (C.M.G.); Duke University Medical Center, Durham, NC (C.G.); Université Sorbonne Paris 6, ACTION Study Group, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Institut de Cardiologie, Paris (G.M.); Penn Heart and Vascular Center, Philadelphia (D.R.); Columbia University, New York (A.R.T.), and Saratoga Cardiology Associates, Saratoga Springs (D.K.) - both in New York; St. Michael's Hospital, Toronto (S.G.), Recherche Médicale Saint-Jérôme, Saint-Jérôme, QC (Y.P.), and Centre de Santé et de Services Sociaux du Nord de Lanaudière-Centre Hospitalier Régional de Lanaud, Saint-Charles-Borromée, QC (S.K.) - all in Canada; Instituto Cardiovascular de Buenos Aires, Buenos Aires (D.C.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Heart Institute (InCor)-University of São Paulo Medical School, São Paulo (J.C.N.); Hospital Central Dr. Ignacio Morones Prieto, San Luis Potosi, Mexico (J.L.L.-P.); the First Affiliated Hospital of Harbin Medical University, Harbin, China (W.L.); and South Oklahoma Heart Research, Oklahoma City (N.T.).
    Background: The cholesteryl ester transfer protein inhibitor evacetrapib substantially raises the high-density lipoprotein (HDL) cholesterol level, reduces the low-density lipoprotein (LDL) cholesterol level, and enhances cellular cholesterol efflux capacity. We sought to determine the effect of evacetrapib on major adverse cardiovascular outcomes in patients with high-risk vascular disease.

    Methods: In a multicenter, randomized, double-blind, placebo-controlled phase 3 trial, we enrolled 12,092 patients who had at least one of the following conditions: an acute coronary syndrome within the previous 30 to 365 days, cerebrovascular atherosclerotic disease, peripheral vascular arterial disease, or diabetes mellitus with coronary artery disease. Read More

    The Effect of Interactions of Single Nucleotide Polymorphisms of APOA1/APOC3 with Food Group Intakes on the Risk of Metabolic Syndrome.
    Avicenna J Med Biotechnol 2017 Apr-Jun;9(2):94-103
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background: The aim of this study was to examine the interaction of dietary food groups and genetic variants of APOA1/APOC3, relative to Metabolic Syndrome (MetS) risk in adults.

    Methods: In this matched nested case-control study, 414 MetS subjects and 414 controls were selected from among participants of Tehran Lipid and Glucose Study. Dietary intake was assessed with the use of a valid and reliable semi-quantitative food frequency questionnaire. Read More

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