2,159 results match your criteria Acute Febrile Neutrophilic Dermatosis


[Cutaneous Manifestations of Sweet Disease].

Brain Nerve 2019 Apr;71(4):334-338

Division of Dermatology, Tohoku Medical and Pharmaceutical University.

Sweet disease, also known as acute febrile neutrophilic dermatosis, is a multisystem inflammatory disorder characterized by painful erythematous plaques and aseptic neutrophilic infiltration of various organs. It is also characterized by fever, polymorphonuclear leukocytosis, and painful erythematous cutaneous plaques. Cutaneous manifestations of Sweet disease are typically painful plaque-forming erythematous papules. Read More

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http://dx.doi.org/10.11477/mf.1416201271DOI Listing
April 2019
2 Reads

European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2019 Update.

Neonatology 2019 Apr 11;115(4):432-451. Epub 2019 Apr 11.

Department of Child Health, Queen's University Belfast and Royal Maternity Hospital, Belfast, United Kingdom.

As management of respiratory distress syndrome (RDS) advances, clinicians must continually revise their current practice. We report the fourth update of "European Guidelines for the Management of RDS" by a European panel of experienced neonatologists and an expert perinatal obstetrician based on available literature up to the end of 2018. Optimising outcome for babies with RDS includes prediction of risk of preterm delivery, need for appropriate maternal transfer to a perinatal centre and timely use of antenatal steroids. Read More

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https://www.karger.com/Article/FullText/499361
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http://dx.doi.org/10.1159/000499361DOI Listing
April 2019
33 Reads

Skin and Systemic Inflammation in Schnitzler's Syndrome Are Associated With Neutrophil Extracellular Trap Formation.

Front Immunol 2019 22;10:546. Epub 2019 Mar 22.

Department of Dermatology and Allergy, Allergie-Centrum-Charité, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Schnitzler's syndrome is a rare autoinflammatory disorder characterized by interleukin-1ß-mediated and neutrophil-dominated inflammation. Neutrophil extracellular traps (NETs) are web-like structures of decondensed chromatin, histones, and antimicrobial peptides released by neutrophils. NETs were initially described in the context of pathogen defense but are also involved in autoimmune-mediated skin diseases. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438918PMC
March 2019
1 Read

Sweet's syndrome in a patient with Crohn's disease.

Proc (Bayl Univ Med Cent) 2018 Oct 19;31(4):460-461. Epub 2018 Sep 19.

Department of Internal Medicine, Baylor Scott & White HealthTempleTexas.

Sweet's syndrome, or acute febrile neutrophilic dermatosis, has previously been associated with underlying inflammatory bowel disease; however, there are fewer than 50 case reports of such an association. Herein, we describe a young woman with Crohn's disease who presented with abrupt onset of a painful, tender erythematous rash on the dorsal hands and face. Read More

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http://dx.doi.org/10.1080/08998280.2018.1496670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413964PMC
October 2018
1 Read

Sweet syndrome induced by radiations during breast cancer treatment.

BMJ Case Rep 2019 Apr 1;12(4). Epub 2019 Apr 1.

Dermatology, Centre Hospitalier de Cornouaille, Quimper, France.

During the follow-up of a woman treated by radiotherapy for an in situ carcinoma of her left breast, radio-induced skin lesions were diagnosed. They appeared not to be simple radiodermatitis but radio-induced Sweet syndrome. Discussions were led on the benefit of completing the last session of radiotherapy for such a low-grade malignancy while considering the risk of complication from radio-induced disease. Read More

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http://dx.doi.org/10.1136/bcr-2017-223938DOI Listing
April 2019
1 Read

Nanotechnology-Mediated Drug Delivery for the Treatment of Obesity and Its Related Comorbidities.

Adv Healthc Mater 2019 Apr 2:e1801184. Epub 2019 Apr 2.

Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.

Obesity is a serious health issue affecting humanity on a global scale. Recognized by the American Medical Association as a chronic disease, the incidence of obesity continues to grow at an accelerating rate and obesity has become one of the major threats to human health. Excessive weight gain is tied to metabolic syndrome, which is shown to increase the risk of chronic diseases, such as heart disease and type 2 diabetes, taxing an already overburdened healthcare system and increasing mortality worldwide. Read More

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http://dx.doi.org/10.1002/adhm.201801184DOI Listing
April 2019
5 Reads

Sweet syndrome in a patient with chronic myelogenous leukemia under dasatinib treatment.

J Dermatol 2019 Apr 1. Epub 2019 Apr 1.

Department of Dermatology, Kansai Medical University, Hirakata, Japan.

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http://dx.doi.org/10.1111/1346-8138.14868DOI Listing
April 2019
6 Reads

Insights Into the Pathogenesis of Sweet's Syndrome.

Front Immunol 2019 12;10:414. Epub 2019 Mar 12.

Oregon Health and Science University, Department of Dermatology, Portland, OR, United States.

Sweet's syndrome, also known as Acute Febrile Neutrophilic Dermatosis, is a rare inflammatory condition. It is considered to be the prototype disease of neutrophilic dermatoses, and presents with acute onset dermal neutrophilic lesions, leukocytosis, and pyrexia. Several variants have been described both clinically and histopathologically. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424218PMC
March 2019
1 Read

Cytokine Profile in Sweet's Syndrome under the Treatment of Pulmonary Toxoplasmosis Complicated with Myelodysplastic Syndrome.

Intern Med 2019 Mar 28. Epub 2019 Mar 28.

Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of The Institute of Medical Science, The University of Tokyo, Japan.

We herein describe a case of Sweet's syndrome (SS) in a patient being treated for pulmonary toxoplasmosis complicated with myelodysplastic syndrome (MDS). The patient's SS developed after the pulmonary toxoplasmosis improved following treatment. We searched his cytokine profiles comprehensively using a bead-based immunoassay. Read More

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http://dx.doi.org/10.2169/internalmedicine.2372-18DOI Listing
March 2019
3 Reads

Proliferative Sweet syndrome associated with pregnancy and low-molecular-weight heparin sodium.

Scand J Rheumatol 2019 Mar 25:1-2. Epub 2019 Mar 25.

a Department of Dermatology , Nanfang Hospital, Southern Medical University , Guangzhou , China.

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http://dx.doi.org/10.1080/03009742.2019.1575979DOI Listing
March 2019
1 Read

A retrospective study of the severe and uncommon variants of erythema nodosum leprosum at a tertiary health center in central India.

Int J Mycobacteriol 2019 Jan-Mar;8(1):29-34

Department of Pathology, Government Medical College, Nagpur, Maharashtra, India.

Background: Erythema nodosum leprosum (ENL) classically presents with tender, coppery, evanescent nodules along with constitutional features and visceral involvement. However, uncommon morphological variants of ENL-like erythema nodosum necroticans, erythema multiforme (EM)-like ENL, Sweet's syndrome (SS)-like ENL, Lucio phenomenon, and reactive perforating type of ENL have also been described in the literature. The primary objective of this study was to describe the clinical features of the severe and uncommon morphological variants of ENL. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_174_18DOI Listing
March 2019
1 Read

Evolution in the Treatment of Psychiatric Disorders: From Psychosurgery to Psychopharmacology to Neuromodulation.

Front Neurosci 2019 15;13:108. Epub 2019 Feb 15.

Department of Neurosurgery, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, United States.

The treatment of psychiatric patients presents significant challenges to the clinical community, and a multidisciplinary approach to diagnosis and management is essential to facilitate optimal care. In particular, the neurosurgical treatment of psychiatric disorders, or "psychosurgery," has held fascination throughout human history as a potential method of influencing behavior and consciousness. Early evidence of such procedures can be traced to prehistory, and interest flourished in the nineteenth and early twentieth century with greater insight into cerebral functional and anatomic localization. Read More

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http://dx.doi.org/10.3389/fnins.2019.00108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384258PMC
February 2019
3 Reads

Sweet syndrome in acute myeloid leukaemia.

Br J Haematol 2019 Feb 20. Epub 2019 Feb 20.

Department of Haematology, Royal Stoke University Hospital, Stoke-on-Trent, UK.

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http://dx.doi.org/10.1111/bjh.15804DOI Listing
February 2019

Dermatologic Urgencies and Emergencies: What Every Pathologist Should Know.

Arch Pathol Lab Med 2019 Feb 20. Epub 2019 Feb 20.

From the Department of Dermatology, Saint Louis University, St Louis, Missouri (Dr Abate);the Departments of Dermatology (Dr Battle),and Pathology (Drs Gardner and Shalin),University of Arkansas for Medical Sciences, Little Rock; and the Department of Dermatology, University of Mississippi Medical Center, Jackson (Dr Emerson).

Context.—: Fatal dermatologic diseases and ones with high morbidity can occur in the inpatient setting. In such cases, prompt and accurate assessment of a bedside skin biopsy is required. Read More

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http://dx.doi.org/10.5858/arpa.2018-0239-RADOI Listing
February 2019
3 Reads

Surfactant replacement therapy for respiratory distress syndrome in preterm infants: United Kingdom national consensus.

Pediatr Res 2019 Feb 19. Epub 2019 Feb 19.

Medical Sciences Division, University Department of Paediatrics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41390-019-0344-5DOI Listing
February 2019
5 Reads

Comparative Study of Frozen and Paraffin-Embedded Sections: Evaluation of Inflammatory Dermatoses.

Isr Med Assoc J 2019 Feb;21(2):82-84

Department of Dermatology, Sourasky Tel Aviv Medical Center, Tel Aviv, Israel.

Background: Frozen section (FS) is often performed when histopathological evaluations are urgently required for implementation of therapeutic measures. In dermatology, this method is most commonly used to evaluate excision margins of tumors. FS are also routinely employed to differentiate toxic epidermal necrolysis from staphylococcal scalded skin syndrome. Read More

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February 2019
9 Reads

Mutational Signature Analysis Reveals NTHL1 Deficiency to Cause a Multi-tumor Phenotype.

Cancer Cell 2019 Feb;35(2):256-266.e5

Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands; Princess Máxima Center for Pediatric Oncology, 3584 CT Utrecht, The Netherlands. Electronic address:

Biallelic germline mutations affecting NTHL1 predispose carriers to adenomatous polyposis and colorectal cancer, but the complete phenotype is unknown. We describe 29 individuals carrying biallelic germline NTHL1 mutations from 17 families, of which 26 developed one (n = 10) or multiple (n = 16) malignancies in 14 different tissues. An unexpected high breast cancer incidence was observed in female carriers (60%). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183058
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http://dx.doi.org/10.1016/j.ccell.2018.12.011DOI Listing
February 2019
25 Reads

Protean Neurologic Manifestations of Two Rare Dermatologic Disorders: Sweet Disease and Localized Craniofacial Scleroderma.

Curr Neurol Neurosci Rep 2019 Feb 12;19(3):11. Epub 2019 Feb 12.

NYU Multiple Sclerosis Comprehensive Care Center, Department of Neurology, New York University School of Medicine, New York, NY, USA.

Purpose Of Review: To describe diverse neurologic and neuroradiologic presentations of two rare, immunologically mediated skin conditions: Sweet disease and localized scleroderma (morphea).

Recent Findings: Core syndromes of neuro-Sweet disease (NSD) are steroid responsiveness, recurrent meningitis, and encephalitis. Focal neurologic, neuro-vascular, and neuro-ophthalmologic syndromes have been reported recently in NSD. Read More

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http://dx.doi.org/10.1007/s11910-019-0929-8DOI Listing
February 2019
2 Reads
3.059 Impact Factor

Cutaneous paraneoplastic syndromes.

Semin Diagn Pathol 2019 Jan 31. Epub 2019 Jan 31.

PRW Laboratories, Charlottesville, VA, United State.

A variety of cutaneous abnormalities can be seen in patients with malignant diseases, some of which are infectious, with others representing direct involvement of the skin by the underlying disorder. Yet another group of lesions can be regarded as associated markers of the malignant process, and, as such, are termed "paraneoplastic." This review considers the latter collection of conditions, grouping them by the generic type of malignancy that is usually linked to the paraneoplasia. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.01.001DOI Listing
January 2019
15 Reads

Sweet syndrome with pseudocarcinomatous hyperplasia: A case report and review of the literature.

J Cutan Pathol 2019 Feb 7. Epub 2019 Feb 7.

Department of Dermatology, University of Minnesota, Minneapolis, Minnesota.

Pseudocarcinomatous (pseudoepitheliomatous) hyperplasia represents reactive epidermal change mimicking squamous cell carcinoma (SCC), owing to a variety of inflammatory and neoplastic phenomena, including deep fungal infections, CD30-positive lymphomas, and others. We report a case of Sweet syndrome (SS) arising in a patient with acute myelogenous leukemia, with persistent orolabial involvement which mimicked SCC both clinically and microscopically, but resolved entirely with adequate corticosteroid treatment. Clinicians should be aware that neutrophilic dermatoses such as SS and pyoderma gangrenosum may rarely exhibit pseudocarcinomatous epidermal changes similar to those seen in soft tissue infections and other inflammatory dermatoses. Read More

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http://dx.doi.org/10.1111/cup.13436DOI Listing
February 2019
1 Read

Sweet syndrome in metastatic melanoma during treatment with dabrafenib and trametinib.

Australas J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1111/ajd.13001DOI Listing
February 2019
1 Read

Giant cellulitis-like Sweet syndrome as an initial clinical presentation of acute myeloblastic leukemia with t(6;9)(p23;q34): DEK-CAN and internal duplications of FMS-like tyrosine kinase 3.

Ann Hematol 2019 Mar 18;98(3):787-788. Epub 2019 Jan 18.

Department of Hematology, Yamagata Prefectural Central Hospital, Yamagata, 990-2292, Japan.

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http://dx.doi.org/10.1007/s00277-019-03613-1DOI Listing
March 2019
11 Reads

Bullous Variant of Sweet's Syndrome as a Consequence of Radioiodine Contrast Exposure.

Cureus 2018 Oct 24;10(10):e3490. Epub 2018 Oct 24.

Internal Medicine, Baystate Medical Center, Springfield , USA.

Bullous variant of Sweet's syndrome (SS) is a rare form of SS, which clinically presents as bullous hemorrhagic rash and demonstrates dermal neutrophilic infiltrates with segregation of dermo-epidermal junction histopathologically. We present a case of a 73-year-old patient, who initially developed a hypersensitivity reaction on exposure to a radiocontrast agent and subsequently developed blistering rashes, which were established to be from bullous SS after exclusion of other possible diagnoses. Contrast media are utilized commonly in the current era of medicine and SS is rarely identified as an adverse event from it. Read More

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http://dx.doi.org/10.7759/cureus.3490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318143PMC
October 2018

Histiocytoid Sweet syndrome harboring an isocitrate dehydrogenase 1 mutation: A case report and retrospective analysis of 29 cases of histiocytoid Sweet syndrome.

J Cutan Pathol 2019 Apr 19;46(4):290-292. Epub 2019 Feb 19.

Division of Dermatology, Albert Einstein College of Medicine, Bronx, New York.

Histiocytoid Sweet syndrome (HSS) is a rare histopathologic variant of Sweet syndrome that demonstrates dermal and/or subcutaneous infiltrate with a prominent component of myeloid cells resembling histiocytes. It has been known to occur in association with hematologic neoplasms, including myelodysplastic syndrome (MDS) and acute myelogenous leukemia, but whether it confers an increased risk of such neoplasms is controversial. Here, we describe a case of a HSS that led to the diagnosis of MDS with an isocitrate dehydrogenase 1 (IDH-1) mutation and a corresponding study looking for additional cases of IDH-1 mutations in biopsies of histiocytoid and conventional Sweet syndrome. Read More

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http://doi.wiley.com/10.1111/cup.13418
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http://dx.doi.org/10.1111/cup.13418DOI Listing
April 2019
7 Reads

Not so sweet; severe Sweet's syndrome presenting as SIRS and pleural effusion.

J Family Med Prim Care 2018 Nov-Dec;7(6):1584-1587

Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.

Acute febrile neutrophilic dermatosis (Sweet's syndrome) is a rare inflammatory condition which presents as abrupt onset of painful erythematous plaques or nodules, often associated with fever and leucocytosis. Many extracutaneous manifestations are described in literature, but pulmonary manifestations and systemic inflammatory response syndrome (SIRS) are rare. Here we report a case of a 35-year-old male who presented with SIRS and pleural effusion. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_289_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293911PMC
January 2019
6 Reads

[The etiology, diagnosis, and treatment of neurological complications in Behçet disease and its related disorder Sweet disease].

Authors:
Kinya Hisanaga

Rinsho Shinkeigaku 2019 Jan 29;59(1):1-12. Epub 2018 Dec 29.

Departments of Neurology and Clinical Research Center, National Hospital Organization Miyagi Hospital.

Behçet disease, and its related disorder Sweet disease, are multisystem inflammatory conditions characterized by muco-cutaneous symptoms. When neuropsychiatric symptoms appear, the two conditions are referred to as neuro-Behçet disease and neuro-Sweet disease. While diagnosing these conditions according to their diagnostic criteria, muco-cutaneous symptoms must be observed; however, neuropsychiatric symptoms may precede muco-cutaneous symptoms. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001238DOI Listing
January 2019
2 Reads

Gradient-based 3D skin roughness rendering from an in-vivo skin image for dynamic haptic palpation.

Skin Res Technol 2019 Jan 3. Epub 2019 Jan 3.

Department of Information & Telecommunication Engineering, Incheon National University, Incheon, Korea.

Background/purpose: Many studies have revealed the importance of palpation for dermatologists; however, palpation is not always possible due to the risk of secondary infections or the risk of damaging the affected area. Thus, haptic rendering for indirect palpation using in-vivo skin images, which will enable to examine a real three-dimensional (3D) skin sample by virtual touch without directly palpating the infected skin area, could be a useful technology in dermatology.

Methods: We propose a new method of accurate 3D skin surface reconstruction using simple gradients from a single skin image for accurate 3D roughness rendering with a haptic device. Read More

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http://dx.doi.org/10.1111/srt.12650DOI Listing
January 2019

Superficial and Deep Cutaneous Involvement by RAS-Associated Autoimmunne Leukoproliferative Disease (RALD Cutis): A Histologic Mimicker of Histiocytoid Sweet Syndrome.

Am J Dermatopathol 2018 Dec 26. Epub 2018 Dec 26.

Department of Pathology, Florida Hospital Orlando, Orlando, FL.

RAS-associated autoimmune leukoproliferative disease (RALD) is a recently described noninfectious and nonmalignant clinical syndrome characterized by autoimmune disorders, massive splenomegaly, modest lymphadenopathy, and monocytosis. On the molecular level, RALD is defined by somatic mutations of either NRAS or KRAS gene in a subset of hematopoietic cells. To date, there is a dearth of well-documented histopathologic description of cutaneous involvement by RALD in the literature. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001332DOI Listing
December 2018
5 Reads

Nutrition and Cardio-Metabolic Risk Factors: Findings from 20 Years of the Tehran Lipid and Glucose Study.

Int J Endocrinol Metab 2018 Oct 13;16(4 Suppl):e84772. Epub 2018 Oct 13.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Context: Genetic and environmental factors contribute to the incidence of metabolic syndrome (MetS). This study aimed to review all findings of studies conducted in framework of the Tehran lipid and glucose study (TLGS) regarding the association of dietary factors with cardio-metabolic risk factors.

Evidence Acquisition: All English-language studies were searched using PubMed and Scopus databases from 2000 to 2017. Read More

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http://dx.doi.org/10.5812/ijem.84772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289298PMC
October 2018
5 Reads

Sweet Syndrome in Pediatrics. A case report.

Rev Chil Pediatr 2018 Aug;89(4):511-515

Servicio de Anatomía Patológica, Hospital Roberto del Río, Chile.

Introduction: Sweet's syndrome is a very rare dermatosis in pediatrics, of unknown pathogenesis, clinically characterized by fever, neutrophilia, raised and painful plaques on the skin of the face, neck, and limbs, and histologically by dermal infiltration of neutrophils.

Objective: To present a clinical case of Sweet Syndrome in a pediatric patient.

Clinical Case: 3-years-old female child, with history of complex chromosomopathy 46XX add(8), with a 7-day history of plaques and blisters on the back and later also on the limbs, associated with high fever, without response to antibiotic treatment pres cribed due to suspicion of bullous impetigo. Read More

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http://dx.doi.org/10.4067/S0370-41062018005000603DOI Listing
August 2018
15 Reads

[Sweet's syndrome induced by pegfilgrastim during a myelodysplastic syndrome AREB2: A case report].

Rev Med Interne 2019 Apr 11;40(4):258-261. Epub 2018 Dec 11.

Service d'hématologie-oncologie, CHU Brugmann, 4, place Arthur Van Gehuchten, 1020 Bruxelles, Belgique.

Introduction: Sweet's syndrome is an acute neutrophilic dermatosis characterized by abrupt onset of skin lesions accompanied by fever, arthralgia, leukocytosis and diffuse neutrophilic infiltration of the dermis, as well as an excellent response to corticosteroid therapy.

Case Report: A 46-year-old patient with myelodysplastic syndrome was admitted for chemotherapy. On the eighth day of chemotherapy, he received a single dose of pegfilgrastim. Read More

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http://dx.doi.org/10.1016/j.revmed.2018.11.007DOI Listing
April 2019
5 Reads

Effects of Geranium Aromatherapy Massage on Premenstrual Syndrome: A Clinical Trial.

Int J Prev Med 2018 5;9:98. Epub 2018 Nov 5.

Department of Research, Barij Essence Pharmaceutical Company, Mashhad, Iran.

Introduction: This study evaluated the effects of geranium aromatherapy massage on premenstrual syndrome (PMS).

Methods: A total of 120 female students with diagnosed PMS were randomly divided into three groups as control group, aromatherapy massage group, and massage group. Essential oil of geranium 2% in almond oil and sweet almond oil were used in aromatherapy massage group and massage group, respectively. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_40_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238350PMC
November 2018
2 Reads

Analysis of Lipid Metabolism, Immune Function, and Neurobehavior in Adult C57BL/6JxFVB Mice After Developmental Exposure to di (2-ethylhexyl) Phthalate.

Front Endocrinol (Lausanne) 2018 21;9:684. Epub 2018 Nov 21.

Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands.

Developmental exposure to di (2-ethylhexyl) phthalate (DEHP) has been implicated in the onset of metabolic syndrome later in life. Alterations in neurobehavior and immune functions are also affected by phthalate exposure and may be linked to the metabolic changes caused by developmental exposure to DEHP. Our goal was to study the effects of developmental exposure to DEHP in the context of metabolic syndrome by integrating different parameters to assess metabolic, neurobehavioral, and immune functions in one model. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2018.00684
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http://dx.doi.org/10.3389/fendo.2018.00684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259287PMC
November 2018
17 Reads

Liquorice (Glycyrrhiza glabra): the journey of the sweet root from Mesopotamia to England.

Authors:
M R Lee

J R Coll Physicians Edinb 2018 Dec;48(4):378-382

112 Polwarth Terrace, Merchiston, Edinburgh EH11 1NN, UK.

Liquorice is a very ancient plant widely used in the East for millennia. It has often been employed in sweets and confectionery and also for minor ailments including cough, constipation and dyspepsia. It was probably carried to Europe by the Cluniac order of monks. Read More

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http://dx.doi.org/10.4997/JRCPE.2018.419DOI Listing
December 2018
3 Reads

Sweet syndrome: a rare feature of ANCA-associated vasculitis or unusual consequence of azathioprine-induced treatment.

Allergy Asthma Clin Immunol 2018 8;14:46. Epub 2018 Nov 8.

1Division of Nephrology, Department of Medicine, University Hospital Limerick, St Nessans Rd, Limerick, Ireland.

Background: Sweet syndrome is a rare skin condition characterised by fever, neutrophilia, and tender erythematous skin lesions and has been reported to occur in association with anti-neutrophil cytoplasmic antibodies (ANCA) as well as complicate treatment with azathioprine therapy. Azathioprine, a relatively safe immunosuppressive, is frequently used to maintain disease remission in the treatment of ANCA-associated vasculitis. The occurrence of Sweet syndrome in a patient with ANCA-positive vasculitis and following treatment with azathioprine prompted us to present this clinical case and share this unusually rare occurrence. Read More

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http://dx.doi.org/10.1186/s13223-018-0265-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223070PMC
November 2018
2 Reads

Low-Dose Methotrexate for the Prevention of Atherosclerotic Events.

N Engl J Med 2019 02 10;380(8):752-762. Epub 2018 Nov 10.

From the Center for Cardiovascular Disease Prevention, Division of Preventive Medicine (P.M.R., B.M.E., A.P., J.G.M., E.Z., V.M., N.P.P., R.J.G.), and the Divisions of Cardiovascular Medicine (P.M.R., B.M.E., P.L., S.Z.G.) and Rheumatology (D.H.S.), Brigham and Women's Hospital, Boston; the National Heart, Lung, and Blood Institute, Bethesda, MD (A.H., Y.R., E.I.); McMaster University, Hamilton (M.G.), the Canadian Collaborative Research Network, Brampton (M.T.), St. Michael's Hospital, Toronto (S.V.), the University of Ottawa Heart Institute, Ottawa (M.L.M.), and KMH Cardiology, Diagnostic and Research Centres, Mississauga (J.J.), ON, and Laval University, Quebec City, QB (O.B.) - all in Canada; Touro University, Vallejo, CA (M.C.); Cardiology Associates Carolina, Morganton, NC (R.S.); Wooster Community Hospital, Wooster (C.O.), and Dayton Veteran Affairs Medical Center, Dayton (M.S.) - both in Ohio; Verde Valley Medical Center, Cottonwood, AZ (S.B.); and Atlanta Heart Specialists, Atlanta (N.S.).

Background: Inflammation is causally related to atherothrombosis. Treatment with canakinumab, a monoclonal antibody that inhibits inflammation by neutralizing interleukin-1β, resulted in a lower rate of cardiovascular events than placebo in a previous randomized trial. We sought to determine whether an alternative approach to inflammation inhibition with low-dose methotrexate might provide similar benefit. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1809798
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http://dx.doi.org/10.1056/NEJMoa1809798DOI Listing
February 2019
30 Reads

Repeatability and effect of blinding of fructose breath tests in patients with functional gastrointestinal disorders.

Neurogastroenterol Motil 2019 Feb 4;31(2):e13497. Epub 2018 Nov 4.

Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.

Background: Breath tests are used as measures of sugar intolerance or malabsorption in patients with functional gastrointestinal disorders (FGID), although the repeatability or anticipatory bias have not been adequately studied. We examined the repeatability and anticipatory bias during fructose breath testing using a nocebo-controlled, randomized, cross-over, and double-blind study design.

Methods: Gastrointestinal symptoms and breath concentrations of hydrogen and methane were documented during breath tests with fructose (given open twice and blinded once), water (blind neutral nocebo) and a cyclamate/saccharine sweetener (blind sweet nocebo) on 5 days in patients with FGID. Read More

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http://dx.doi.org/10.1111/nmo.13497DOI Listing
February 2019
7 Reads

Clinical Features of Neutrophilic Dermatosis Variants Resembling Necrotizing Fasciitis.

JAMA Dermatol 2019 Jan;155(1):79-84

Department of Dermatology, University of California San Francisco, San Francisco.

Importance: Pyoderma gangrenosum and necrotizing Sweet syndrome are diagnostically challenging variants of neutrophilic dermatosis that can clinically mimic the cutaneous and systemic features of necrotizing fasciitis. Improved characterization of these rare variants is needed, as improper diagnosis may lead to inappropriate or delayed treatment and the potential for morbidity.

Objective: To determine the characteristics of necrotizing neutrophilic dermatosis to improve diagnostic accuracy and distinguish from infection. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.3890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439570PMC
January 2019
17 Reads

Cryptococcus-like changes in the setting of vasculitis.

J Cutan Pathol 2019 Feb 27;46(2):143-147. Epub 2018 Nov 27.

Department of Medicine, Division of Dermatology, Albert Einstein College of Medicine/Montefiore Medical Center, New York, New York.

Cutaneous vasculitis has many underlying causes, and the clinical and histological findings often overlap. Inflammatory vasculitis can mimic infection; however, distinction is critical for the timely institution of appropriate therapy. We present two patients who had generalized polymorphous eruptions whose cutaneous pathology showed vasculitis with unusual haloed yeast-like cells within the inflammatory infiltrate, mimicking Cryptococcus. Read More

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http://doi.wiley.com/10.1111/cup.13380
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http://dx.doi.org/10.1111/cup.13380DOI Listing
February 2019
15 Reads

Silver Fir (Abies alba) Extracts Inhibit Enzymes Involved in Blood Glucose Management and Protect against Oxidative Stress in High Glucose Environment.

Plant Foods Hum Nutr 2019 Mar;74(1):47-53

Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000, Ljubljana, Slovenia.

The diet rich in fruits and vegetables reduces the risk of metabolic syndrome, including diabetes development by various mechanisms of action, mainly due to the presence of polyphenolic compounds. Extracts from different conifer species are known to be a rich source of various polyphenols. In the present study we elucidated the in vitro mechanism of anti-diabetic activity of silver fir (Abies alba) wood and bark extracts and compared their activity to non-coniferous sweet chestnut wood extract and standardized maritime pine bark extract. Read More

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http://link.springer.com/10.1007/s11130-018-0698-6
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http://dx.doi.org/10.1007/s11130-018-0698-6DOI Listing
March 2019
12 Reads

Recurrent Sweet's syndrome in a patient with multiple myeloma.

Clin Case Rep 2018 Oct 21;6(10):1958-1960. Epub 2018 Aug 21.

Department of Biomedicine and Prevention University of Rome Tor Vergata Rome Italy.

We report on a case of Sweet's syndrome associated with multiple myeloma, as harbinger for disease relapse. Read More

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http://dx.doi.org/10.1002/ccr3.1764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186870PMC
October 2018
13 Reads

Effects of oral supplementation with FOS and GOS prebiotics in women with adult acne: the "S.O. Sweet" study: a proof-of-concept pilot trial.

Clin Cosmet Investig Dermatol 2018 8;11:445-449. Epub 2018 Oct 8.

Dermatology Clinic, University of Catania, Catania, Italy.

Background: We evaluated the effects of 3-month prebiotic oral supplementation with fructo-oligosaccharides (FOS) and galacto-oligosaccharides (GOS) on glucose and lipid metabolic parameters in women with adult acne (female adult acne).

Methods: Twelve women, mean age 35 years, with mild to moderate acne were enrolled. Exclusion criteria were severe acne, body mass index (BMI) >25, history of diabetes mellitus, polycystic ovary syndrome, regular intake of prebiotics or probiotics, and history of inflammatory intestinal diseases. Read More

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http://dx.doi.org/10.2147/CCID.S179627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181472PMC
October 2018
9 Reads

Reduced Susceptibility to Sugar-Induced Metabolic Derangements and Impairments of Myocardial Redox Signaling in Mice Chronically Fed with D-Tagatose when Compared to Fructose.

Oxid Med Cell Longev 2018 19;2018:5042428. Epub 2018 Sep 19.

Department of Drug Science and Technology, University of Turin, Italy.

Background: D-tagatose is an isomer of fructose and is ~90% as sweet as sucrose with less caloric value. Nowadays, D-tagatose is used as a nutritive or low-calorie sweetener. Despite clinical findings suggesting that D-tagatose could be beneficial in subjects with type 2 diabetes, there are no experimental data comparing D-tagatose with fructose, in terms of metabolic derangements and related molecular mechanisms evoked by chronic exposure to these two monosaccharides. Read More

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http://dx.doi.org/10.1155/2018/5042428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169220PMC
December 2018
3 Reads

Messy Play Therapy in the Treatment of Food Aversion in a Patient With Intestinal Failure: Our Experience.

JPEN J Parenter Enteral Nutr 2019 Mar 25;43(3):412-418. Epub 2018 Sep 25.

Department of Pediatric Surgery, Meyer Children's Hospital, University of Florence, Florence, Italy.

Background: Food aversion (FA) is an eating behavior where children refuse solid or fluid intake. FA can compromise the weaning off parenteral nutrition (PN) in children with intestinal failure (IF), reducing their quality of life (QoL). Around 25% of children with IF experience FA, but few data are available on interventions to get over FA. Read More

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http://dx.doi.org/10.1002/jpen.1433DOI Listing
March 2019
19 Reads

Sweet Syndrome in a Patient With Systemic Lupus Erythematosus.

J Clin Rheumatol 2018 Sep 21. Epub 2018 Sep 21.

From the Division of Internal Medicine, Spectrum Health-Michigan State University, College of Human Medicine, Grand Rapids, MI.

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http://dx.doi.org/10.1097/RHU.0000000000000904DOI Listing
September 2018
4 Reads

The Neuromodulation Appropriateness Consensus Committee on Best Practices for Dorsal Root Ganglion Stimulation.

Neuromodulation 2019 Jan 24;22(1):1-35. Epub 2018 Sep 24.

Evidence-Based Pain Management Research and Education, Cleveland Clinic, Cleveland, OH, USA.

Introduction: The Neuromodulation Appropriateness Consensus Committee (NACC) is dedicated to improving the safety and efficacy of neuromodulation and thus improving the lives of patients undergoing neuromodulation therapies. With continued innovations in neuromodulation comes the need for evolving reviews of best practices. Dorsal root ganglion (DRG) stimulation has significantly improved the treatment of complex regional pain syndrome (CRPS), among other conditions. Read More

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http://doi.wiley.com/10.1111/ner.12845
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http://dx.doi.org/10.1111/ner.12845DOI Listing
January 2019
9 Reads

Neonatal lupus erythematosus or Sweet syndrome?

JAAD Case Rep 2018 Sep 14;4(8):780-783. Epub 2018 Sep 14.

National Health Laboratory Services, Red Cross Children's Hospital, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1016/j.jdcr.2018.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141640PMC
September 2018
1 Read

Acute febrile neutrophilic dermatosis in a patient with Crohn's disease: case report and review of the literature.

Acta Dermatovenerol Alp Pannonica Adriat 2018 09;27(3):161-163

Department of Gastroenterology, University Medical Centre Maribor, Maribor, Slovenia.

Crohn's disease is a chronic inflammatory bowel disease. The disease is characterized by acute exacerbations with diarrhea, abdominal pain, fever, anorexia, intestinal bleeding, and weight loss. Immune-mediated diseases that are frequently associated with Crohn's disease include arthritis, ankylosing spondylitis, sacroiliitis, episcleritis, uveitis, and skin lesions, such as erythema nodosum and pyoderma gangrenosum. Read More

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September 2018
22 Reads

Sweet syndrome following a positive Mantoux test due to pulmonary tuberculosis.

Dermatol Ther 2019 01 30;32(1):e12754. Epub 2018 Oct 30.

Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome, Italy.

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http://doi.wiley.com/10.1111/dth.12754
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http://dx.doi.org/10.1111/dth.12754DOI Listing
January 2019
20 Reads

[Sweet syndrome in a 5-year-old girl].

Arch Argent Pediatr 2018 Oct;116(5):e671-e674

Servicio de Pediatría del Instituto Roosevelt, Universidad del Rosario.

Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is an infrequent dermatological disorder in pediatrics. Clinically it is characterized by the development of papular and/or nodular lesions of a reddish-violet coloration with local hypersensitivity. We report the case of a 5-year-old female who consulted 1 month after the appearance of the lesion in the nasal arch. Read More

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http://dx.doi.org/10.5546/aap.2018.e671DOI Listing
October 2018
1 Read