658 results match your criteria Acute Fatty Liver of Pregnancy


Swansea criteria score in acute fatty liver of pregnancy.

Chin Med J (Engl) 2022 04 5;135(7):860-862. Epub 2022 Apr 5.

Intensive Care Unit, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.

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Acute Liver Failure.

Crit Care Nurs Q 2022 Jul-Sep 01;45(3):248-257

Division of Pulmonary and Critical Care Medicine, Allegheny Health Network, Pittsburgh, Pennsylvania (Drs Ledgerwood, Villgran, Dumont, and DiSilvio); and Department of Nursing, Allegheny Health Network, Allegheny General Hospital, Pittsburgh, Pennsylvania (Mr Mardirossian).

Acute liver failure (ALF) is a rare but life-threatening disease process that can result in rapidly progressive encephalopathy, elevated intracranial pressure, and multiorgan failure. In the United States, the 2 most common causes of ALF in the intensive care unit (ICU) are acetaminophen overdose and hypoxic-ischemic hepatopathy. Less common causes of ALF include alcoholic hepatitis, nonacetaminophen drug-induced liver injury, acute viral hepatitis, Wilson's disease, autoimmune hepatitis, and acute fatty liver of pregnancy. Read More

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Liver Diseases in the Parturient.

Indian J Crit Care Med 2021 Dec;25(Suppl 3):S248-S254

Department of Gastroenterology, Seth GS Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India.

Sundaram S, Giri S. Liver Diseases in the Parturient. Indian J Crit Care Med 2021;25(Suppl 3):S248-S254. Read More

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December 2021

Urea(lly) Got Me: An Uncommon Etiology of Peripartum Liver Failure.

ACG Case Rep J 2022 May 20;9(5):e00780. Epub 2022 May 20.

Madigan Army Medical Center, Tacoma, WA.

A 23-year-old woman presented 4 days postpartum for agitation and confusion, with initial evaluation consistent with acute fatty liver of pregnancy (AFLP). Later in her course, an amino acid panel was highly suggestive of citrullinemia type 1. She was started on arginine supplementation and glycerol phenylbutyrate and evaluated for a liver transplant. Read More

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[Recurrent acute fatty liver of pregnancy: About a case and a review of the literature].

Gynecol Obstet Fertil Senol 2022 Apr 27. Epub 2022 Apr 27.

CHU Mohammed VI, service de gynécologie-obstétrique, Oujda, Maroc.

Acute fatty liver of pregnancy (AFLP) is a specific but rare hepatopathy that can usually complicate the third trimester of pregnancy. It is potentially fatal for the mother and the fetus. To our knowledge, only eight cases of recurrence have been published, we report a new case. Read More

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Diagnosis and management of thrombocytopenia in pregnancy.

Authors:
Young Hoon Park

Blood Res 2022 Apr;57(S1):79-85

Division of Hematology-Oncology, Department of Internal Medicine, Ewha Womans University Mokdong Hospital, Seoul, Korea.

Thrombocytopenia, defined as platelet count <150×10/L, is frequently observed by physicians during pregnancy, with an incidence of approximately 10% of all pregnancies. Most of the cases of thrombocytopenia in pregnancy are due to gestational thrombocytopenia, which does not confer an increased risk of maternal bleeding. However, because other causes can be associated with life-threatening events, such as severe bleeding, that can affect to maternal and fetal outcomes, differentiating other cause of thrombocytopenia, which includes preeclampsia, HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome, acute fatty liver of pregnancy, immune thrombocytopenia, hereditary thrombocytopenia, antiphospholipid syndrome, thrombotic thrombocytopenic purpura, and atypical hemolytic uremic syndrome, is important. Read More

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Mitochondrial Dysfunction and Acute Fatty Liver of Pregnancy.

Int J Mol Sci 2022 Mar 25;23(7). Epub 2022 Mar 25.

Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO 65211, USA.

The liver is one of the richest organs in mitochondria, serving as a hub for key metabolic pathways such as β-oxidation, the tricarboxylic acid (TCA) cycle, ketogenesis, respiratory activity, and adenosine triphosphate (ATP) synthesis, all of which provide metabolic energy for the entire body. Mitochondrial dysfunction has been linked to subcellular organelle dysfunction in liver diseases, particularly fatty liver disease. Acute fatty liver of pregnancy (AFLP) is a life-threatening liver disorder unique to pregnancy, which can result in serious maternal and fetal complications, including death. Read More

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[Clinical analysis of 34 cases of acute fatty liver of pregnancy].

Authors:
W J Hao L Y Zou

Zhonghua Fu Chan Ke Za Zhi 2022 Mar;57(3):172-178

Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China.

To analyze the characteristics, diagnosis and prognosis of acute fatty liver of pregnancy (AFLP), and to guide the management of AFLP patients. The clinical data of 34 AFLP patients admitted to Beijing Obstetrics and Gynecology Hospital, Capital Medical University from January 2009 to December 2019 were retrospectively analyzed. The general situation, diagnostic characteristics, treatment and maternal and neonatal prognosis of the AFLP patients were collected and analyzed. Read More

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Pregnancy-Associated Liver Diseases.

Gastroenterology 2022 Jul 8;163(1):97-117.e1. Epub 2022 Mar 8.

Department of Women and Children's Health, King's College London, London, UK.

The liver disorders unique to pregnancy include hyperemesis gravidarum, intrahepatic cholestasis of pregnancy, acute fatty liver of pregnancy, and preeclampsia-associated hepatic impairment, specifically hemolysis, elevated liver enzymes, and low platelet count syndrome (HELLP). Their importance lies in the significant maternal and fetal/neonatal morbidity and mortality. Expeditious diagnosis and clinical evaluation is critical to ensure timely, appropriate care and minimize risks to the pregnant woman and her fetus/baby. Read More

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Therapeutic plasma exchange in acute fatty liver of pregnancy: a case report and literature review.

Pan Afr Med J 2021 13;40:220. Epub 2021 Dec 13.

India Institute of Medical Sciences, Rishikesh, India.

Acute fatty liver of pregnancy (AFLP) is characterised by acute liver failure that occurs most commonly in the third trimester of pregnancy. Emergent delivery of the foetus reverses liver failure in most cases. Rarely, termination of pregnancy may not reverse liver failure, and adjunct interventions may be required. Read More

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February 2022

Timely identification and successful treatment of acute fatty liver of pregnancy without obvious clinical symptoms: Case reports.

Medicine (Baltimore) 2022 Feb;101(5):e28723

New drug screening center, Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing, PR China.

Rationale: Acute fatty liver of pregnancy (AFLP) is a rare and potentially fatal complication that occurs in the third trimester or early postpartum period. The diagnosis of AFLP is based on typical clinical and laboratory features and imaging examinations.

Patient Concerns: Case 1: a 25-year-old pregnant woman was hospitalized for threatened preterm birth at gestation of 35weeks and 2 days gestation. Read More

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February 2022

Analysis of Causes of Hepatic Dysfunction in Obstetric Patients in India: A Systematic Review.

Indian J Crit Care Med 2022 Jan;26(1):114-122

Department of Critical Care Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: Epidemiology of liver disease in obstetric patients shows geographical variation depending upon the prevalence of preeclampsia, viral hepatitis, and tropical vector-borne diseases like malaria, leptospirosis, etc. We undertook the current systematic review to analyze the causes of hepatic dysfunction in obstetric patients in India and identify the gaps in the literature and reporting.

Materials And Methods: We did a systematic review of studies reporting the causes of hepatic dysfunction in obstetric patients in India. Read More

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January 2022

Predictors of adverse maternal outcome in jaundiced pregnant women identified as having pregnancy-specific liver disease (P-sLD).

J Obstet Gynaecol 2022 Jan 24:1-7. Epub 2022 Jan 24.

Department of Medicine, JIPMER, Puducherry, India.

We aimed to study the factors including model for end stage liver disease (MELD) score in predicting mortality in women with pregnancy-specific liver diseases (P-sLD). A total of 154 women with clinical jaundice were studied of which 138 women were diagnosed with P-sLD. The most common P-sLD was HELLP syndrome (51. Read More

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January 2022

DIC in Pregnancy - Pathophysiology, Clinical Characteristics, Diagnostic Scores, and Treatments.

J Blood Med 2022 6;13:21-44. Epub 2022 Jan 6.

Department of Haematology, Manchester Royal Infirmary, Manchester, UK.

Obstetrical hemorrhage and especially DIC (disseminated intravascular coagulation) is a leading cause for maternal mortality across the globe, often secondary to underlying maternal and/or fetal complications including placental abruption, amniotic fluid embolism, HELLP syndrome (hemolysis, elevated liver enzymes and low platelets), retained stillbirth and acute fatty liver of pregnancy. Various obstetrical disorders can present with DIC as a complication; thus, increased awareness is key to diagnosing the condition. DIC patients can present to clinicians who may not be experienced in a variety of aspects of thrombosis and hemostasis. Read More

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January 2022

[Clinical characteristics of critically ill pregnant women with different admission methods to intensive care unit: data analysis from 2006 to 2019 in the university hospital].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Oct;33(10):1249-1254

Department of Intensive Care Unit, Peking University Third Hospital, Beijing 100191, China.

Objective: To compare the clinical characteristics of critically ill pregnant women admitted to the intensive care unit (ICU) with different admission methods, in order to make more effective and rational use of ICU resources.

Methods: A retrospective study was conducted. The clinical data of critically ill pregnant women admitted to ICU of Peking University Third Hospital from January 2006 to July 2019 were analyzed. Read More

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October 2021

Acute Fatty Liver of Pregnancy.

Am J Case Rep 2021 Nov 28;22:e933252. Epub 2021 Nov 28.

Graduate Medical Education Intarnal Medicine, Piedmont Athens Regional Medical Center, Athens, GA, USA.

BACKGROUND Acute fatty liver of pregnancy (AFLP) is a rare obstetric emergency resulting from microvesicular infiltration of the liver by fat, leading to liver failure. It usually presents at 36 weeks of gestation, and risk factors include twin pregnancy and low BMI. The presentation of AFLP is nonspecific, requiring a high index of suspicion. Read More

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November 2021

State of the Art in Hepatic Dysfunction in Pregnancy.

Healthcare (Basel) 2021 Oct 31;9(11). Epub 2021 Oct 31.

Department of Internal Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Hepatic dysfunction in pregnant women is always challenging for the obstetrician, as the spectrum of hepatic abnormalities can be very large and have various implications, both for mother and fetus. There is a diagnostic and therapeutic polymorphism of hepatic dysfunction in pregnancy and insufficient knowledge related to the etiopathogenesis and epidemiology of this disease. The clinical forms of hepatic dysfunction encountered in pregnancy can vary from liver diseases related to pregnancy (e. Read More

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October 2021

Liver pathology in pregnancy.

Pathol Int 2022 Jan 24;72(1):1-13. Epub 2021 Nov 24.

Department of Pathology, Division of Gastrointestinal/Liver Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Liver dysfunction occurs in up to 3% of pregnancies and can be due to pregnancy-associated liver injury, exacerbation of pre-existing liver disease, or co-incident with pregnancy. The most common form of pregnancy-associated liver injury is intrahepatic cholestasis of pregnancy (ICP). This condition is typically benign and self-limited, but is associated with fetal morbidity and mortality with high levels of serum bile acids. Read More

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January 2022

[Early-stage clinical features, diagnosis and treatment progress of pregnancy-related liver disease].

Zhonghua Gan Zang Bing Za Zhi 2021 Oct;29(10):923-926

Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang 110022, China.

Pregnancy-related liver disease is a group of severe diseases that usually resulting in worsening clinical outcome in pregnant women and fetuses. Therefore, diagnosis and treatment at early-stage are essential. This paper reviews the early-stage clinical features, pathogenesis, diagnosis and treatment key points of common pregnancy-related liver diseases such as hyperemesis gravidarum, intrahepatic cholestasis of pregnancy, hemolysis, elevated liver enzymes and low platelet syndrome, and acute fatty liver of pregnancy, in order to help clinicians, improve their understanding of pregnancy-related liver disease. Read More

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October 2021

Gestational Diabetes Mellitus Complicated by Hemolysis, Elevated Liver Enzymes, and Low Platelet Count After Decreased Need for Insulin: 2 Cases.

Am J Case Rep 2021 Nov 8;22:e933460. Epub 2021 Nov 8.

Department of Obstetrics and Gynecology, International University of Health and Welfare, Narita, Chiba, Japan.

BACKGROUND When a woman becomes pregnant, the placenta produces human placental lactogen (hPL). The anti-insulin effect of hPL raises maternal blood glucose levels, allowing the fetus to use glucose as a nutrient. Because hPL is produced by the placenta until delivery, insulin requirements in patients with gestational diabetes mellitus (GDM) typically increase, but in some cases, they may decrease. Read More

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November 2021

Corrigendum: Risk Factors for Maternal and Fetal Mortality in Acute Fatty Liver of Pregnancy and New Predictive Models.

Front Med (Lausanne) 2021 19;8:786395. Epub 2021 Oct 19.

Department of Critical Care Medicine, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

[This corrects the article DOI: 10.3389/fmed.2021. Read More

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October 2021

A Rare Disease Presenting Postpartum: Acute Fatty Liver of Pregnancy.

Case Rep Obstet Gynecol 2021 30;2021:1143470. Epub 2021 Sep 30.

University of Costa Rica, San José, Costa Rica.

Acute fatty liver of pregnancy is a rare but highly fatal disease affecting women most frequently during the third trimester of pregnancy or in the postpartum period. It is considered a diagnosis of exclusion and requires a timely diagnosis to avoid maternal mortality. We present the case of a 33-year-old primigravida who required an emergency cesarean section due to fetal bradycardia. Read More

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September 2021

A Systematic Approach to Pregnancy-Specific Liver Disorders.

Gastroenterol Hepatol (N Y) 2021 Jul;17(7):322-329

Department of Medicine, University of California at Los Angeles, Los Angeles, California.

Consultation for liver disease during pregnancy is challenging for both the hepatologist and gynecologist, as normal physiologic changes during pregnancy can mimic chronic liver disease. Pregnancy-specific liver disorders are leading causes of abnormal liver function tests during pregnancy. Moreover, up to 3% of all pregnant women in developed countries experience liver diseases nonspecific to pregnancy. Read More

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Acute fatty liver of pregnancy at 19 weeks and 0 days of gestation after prolonged hyperemesis gravidarum.

J Obstet Gynaecol Res 2021 Dec 30;47(12):4467-4471. Epub 2021 Sep 30.

Department of Obstetrics and Gynecology, Kanto Rosai Hospital, Kawasaki, Japan.

Acute fatty liver of pregnancy (AFLP) is a rare disorder that typically develops in the third trimester. We successfully diagnosed and treated a case of AFLP that developed at 18 weeks' gestation. A 34-year-old woman-gravida 4, para 3-presented with continuous vomiting and abdominal pain and developed convulsive seizures and lost consciousness after transfusion therapy. Read More

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December 2021

Survival of a case of pre-eclampsia complicated with acute fatty liver of pregnancy and acute pancreatitis.

Trop Doct 2022 Jan 22;52(1):205-208. Epub 2021 Sep 22.

Professor, Department of Hepatology and Gasteroentology, National Liver Institute, Menoufia University, Shebeen El Kom, Egypt.

Acute fatty liver of pregnancy (AFLP) and acute pancreatitis are peculiar complications of pregnancy. When acute pancreatitis occurs co-incidentally with acute fatty liver of pregnancy, mortality is high. Here, we report a case of a 22-year-old lady in her 36th week of gestation, who presented with pre-eclampsia, acute fatty liver of pregnancy and acute pancreatitis. Read More

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January 2022

Leptospirosis in pregnancy: A systematic review.

PLoS Negl Trop Dis 2021 09 14;15(9):e0009747. Epub 2021 Sep 14.

National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom.

Introduction: Leptospirosis is a leading zoonotic disease worldwide with more than 1 million cases in the general population per year. With leptospirosis being an emerging infectious disease and as the world's environment changes with more floods and environmental disasters, the burden of leptospirosis is expected to increase. The objectives of the systematic review were to explore how leptospirosis affects pregnancy, its burden in this population, its effects on maternal and fetal outcomes and the evidence base surrounding treatment options. Read More

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September 2021

Fever, cough and gastrointestinal symptoms in a pregnant woman.

Clin Med (Lond) 2021 09;21(5):e526-e528

Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

Despite distinct diagnostic criteria, several gastrointestinal pathologies can masquerade haemophagocytic lymphohistiocytosis (HLH) during the peripartum period. Acute fatty liver of pregnancy, HELLP (haemolysis, elevated liver enzymes and low platelets) syndrome, miliary tuberculosis, visceral leishmaniasis, abdominal surgical emergencies, haemolytic anaemias and haematological malignancies may have clinical and laboratory presentation similar to that of HLH. In this report, we present the case of a 26-year-old woman with 38-weeks' gestation and abdominal pain, vomiting, intermittent fever and non-productive cough for 1-2 months. Read More

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September 2021

Liver diseases in pregnancy.

Clin Med (Lond) 2021 09;21(5):e441-e445

Oxford University Hospitals NHS Foundation Trust, Oxford, UK and honorary senior clinical lecturer, University of Oxford, Oxford, UK.

Liver disease in pregnancy can be related to a pre-existing condition (such as autoimmune liver disease) or arise as a consequence of pregnancy. In women with pre-existing disease, pre-pregnancy counselling is important to discuss the potential complications that may occur during pregnancy and how best to manage these. Acute fatty liver of pregnancy and HELLP (haemolysis, elevated liver enzymes and low platelets) syndrome are pregnancy-related liver diseases and are considered obstetric emergencies. Read More

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September 2021

Viscoelastic Hemostatic Assays for Postpartum Hemorrhage.

J Clin Med 2021 Aug 31;10(17). Epub 2021 Aug 31.

Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

This article discusses the importance and effectiveness of viscoelastic hemostatic assays (VHAs) in assessing hemostatic competence and guiding blood component therapy (BCT) in patients with postpartum hemorrhage (PPH). In recent years, VHAs such as thromboelastography and rotational thromboelastometry have increasingly been used to guide BCT, hemostatic adjunctive therapy and prohemostatic agents in PPH. The three pillars of identifying hemostatic competence include clinical observation, common coagulation tests, and VHAs. Read More

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Analysis of clinical characteristics and genetic testing in patients with acute fatty liver of pregnancy: a retrospective study.

BMC Pregnancy Childbirth 2021 Sep 8;21(1):617. Epub 2021 Sep 8.

Department of Hepatology, Mengchao Hepatobiliary Hospital, Fujian Medical University, Fuzhou, 350025, Fujian, China.

Background: Acute fatty liver of pregnancy (AFLP) is an acute, rare and potentially lethal disease typically occurring in the third trimester of pregnancy. So far, there is no effective means of prevention. Therefore, in this study, we retrospectively analyzed the clinical features of AFLP patients for a better understanding. Read More

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September 2021