619 results match your criteria Acute Fatty Liver of Pregnancy


Sickle cell anaemia in vaso-occlusive crisis and acute fatty liver of pregnancy: a case report.

Ghana Med J 2020 Sep;54(3):201-203

Department of Obstetrics and Gynaecology, University of Benin Teaching Hospital, Benin city, Edo State, Nigeria.

Acute fatty liver of pregnancy (AFLP) is an uncommon condition that manifests in the third trimester of pregnancy. Its association with vaso-occlusive crisis from Sickle Cell Anaemia is not common. Published data on the simultaneous occurrence of these two conditions is rare, hence this case report. Read More

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September 2020

Acute fatty liver of pregnancy causes severe acute pancreatitis and stillborn fetus: A case report.

Medicine (Baltimore) 2021 Apr;100(16):e25524

Department of Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, China.

Rationale: Acutefatty liver of pregnancy (AFLP) is a potentially fatal obstetric emergency characterized by acute hepatic failure secondary to fatty infiltration. The resultant effects include coagulopathy, electrolyte abnormalities, and multisystem organ dysfunction. Pancreatitis typically develops after the onset of renal and hepatic dysfunction. Read More

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Comparison of maternal and neonatal outcomes between acute fatty liver of pregnancy and hemolysis, elevated liver enzymes and low platelets syndrome: a retrospective cohort study.

BMC Pregnancy Childbirth 2021 Apr 12;21(1):293. Epub 2021 Apr 12.

Department of Obstetrics and Gynecology, Mackay Memorial Hospital, No. 92, Section 2, Zhong-Shan North Road, 10449, Taipei, Taiwan.

Background: Acute fatty liver of pregnancy (AFLP) and hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome are two uncommon disorders that mimic each other clinically, but are distinct pathophysiologically. This study aimed to compare maternal and neonatal outcomes between AFLP and HELLP syndrome.

Methods: This retrospective cohort study was performed at a tertiary referral center in Taiwan between June 2004 and April 2020. Read More

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The Acute Onset of Autoimmune Hepatitis During Pregnancy in the Absence of Hypergammaglobulinemia and Autoantibodies.

Intern Med 2021 Apr 12. Epub 2021 Apr 12.

Department of Internal Medicine, Japanese Red Cross Kochi Hospital, Japan.

The onset of autoimmune hepatitis (AIH) during pregnancy is rare and often poses a diagnostic challenge. A 29-year-old Japanese woman experienced epigastric pain and nausea during the third trimester of her third pregnancy. Three days after the symptom onset, an emergency Caesarean section was performed because of suspected acute fatty liver of pregnancy; however, the patient's liver dysfunction worsened afterward. Read More

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Pregnancy-associated diabetes insipidus in Japan-a review based on quoting from the literatures reported during the period from 1982 to 2019.

Endocr J 2021 Apr 23;68(4):375-385. Epub 2021 Mar 23.

Komatsu University#, Komatsu 923-0921, Japan.

This Review Article overviews the literature on diabetes insipidus (DI) associated with pregnancy and labor in Japan published from 1982 to 2019. The total number of patients collected was 361, however, only one-third of these cases had detailed pathophysiologic information enabling us to identify the respective etiology and subtype. Pregnancy-associated DI can be divided into 3 etiologies, central (neurogenic) DI, nephrogenic DI, and excess vasopressinase-associated DI. Read More

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Two Fatty Liver Conditions Masquerading as Autoimmune Hepatitis.

Case Reports Hepatol 2021 9;2021:8820350. Epub 2021 Mar 9.

Prisma Health-Upstate, University of South Carolina School of Medicine-Greenville Department of Medicine, Division of Gastroenterology & Liver Center, 890 W. Faris Rd., Suite 100, Greenville, SC 29605, USA.

Acute fatty liver of pregnancy (AFLP) is a rare obstetric condition that classically presents in the third trimester or early postpartum period and can lead to liver failure and death. Only six second trimester AFLP cases have been reported in the English literature. We present the earliest case of AFLP at 15 weeks of gestation confounded by a high titer anti-nuclear antibody (ANA >1 : 1280) and concern for autoimmune hepatitis. Read More

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Clinicobiochemical Parameters and Predictors of Liver Disease in Hospitalized Asian Indian Pregnant Women in a Tertiary Care Center in Northern India.

Cureus 2021 Feb 17;13(2):e13405. Epub 2021 Feb 17.

Medicine, C U Shah Medical College, Surendranagar, IND.

Introduction  During pregnancy, liver dysfunction is more frequent than expected and may require specialized care. For the early diagnosis, it is important to determine if changes in liver physiology may develop into liver disease. Liver disease during pregnancy may require intervention from a hepatologist for adequate monitoring of mother-fetus health outcomes. Read More

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February 2021

A case of recurrence of adult-onset Still's disease in the third trimester: a case report and literature review.

BMC Pregnancy Childbirth 2021 Feb 24;21(1):163. Epub 2021 Feb 24.

Department of Obstetrics and Gynecology, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.

Background: Adult-onset Still's disease (AOSD) is a self-inflammatory disease showing macrophage and neutrophil activation by inflammatory cytokines such as TNF-α, IL-6, and IL-18. Although some cases with the flare of AOSD during pregnancy have been reported, most had flares in the first or second trimester and few had flares in the third trimester. In this report, we present the case of a patient with recurrent flare of AOSD in the third trimester and discuss the management of AOSD in the third trimester with the review of previous literatures. Read More

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February 2021

Pregnancy-associated hemolytic uremic syndrome.

Saudi J Kidney Dis Transpl 2020 Nov-Dec;31(6):1180-1188

Department of Medicine, Dr. Soliman Fakeeh Hospital, Jeddah, Saudi Arabia; Department of Nephrology, Urology and Nephrology Center, Mansoura, Egypt; Fakeeh College of Medical Sciences, Jeddah, Saudi Arabia.

Pregnancy-associated hemolytic uremic syndrome (P-aHUS) is not an uncommon condition. It is considered a medical emergency that is associated with a high risk of mortality and serious morbidity. End-stage renal disease as a consequence of P-aHUS occurs in >50% of the patients if left untreated; the majority of identified cases (79%) are during the postpartum period. Read More

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February 2021

Acute Fatty Liver of Pregnancy.

Obstet Gynecol 2021 Mar;137(3):535-546

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas.

Acute fatty liver of pregnancy is a rare, but potentially fatal obstetric disorder characterized principally by varying degrees of hepatic failure with an onset typically in late pregnancy. This review outlines the etiopathogenesis and describes the multiorgan involvement that often results in a number of clinical and laboratory aberrations. These laboratory derangements provide distinct features to differentiate from other obstetric complications, such as hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. Read More

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Liver Biopsy in Pregnancy: Two Case Reports and Review of the Literature.

Dig Dis Sci 2021 Jan 12. Epub 2021 Jan 12.

Program Director- Advanced Endoscopy Fellowship, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

The etiology of most cases of liver diseases in pregnancy can be diagnosed with a thorough history, physical examination, laboratory values, serology, and noninvasive imaging. However, atypical clinical and laboratory presentations of liver diseases/chemistries require a liver biopsy to render an accurate diagnosis in cases where the biopsy results affect the timing of delivery or impact choice of medical therapy. According to the American College of Gastroenterology, liver biopsy can be effectively and safely conducted in pregnant women. Read More

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January 2021

Acute fatty liver of pregnancy - A short review.

Aust N Z J Obstet Gynaecol 2021 04 31;61(2):183-187. Epub 2020 Dec 31.

Department of Obstetrics and Gynaecology, University Hospital Saint-Pierre (Université Libre de Bruxelles), Brussels, Belgium.

Acute fatty liver of pregnancy (AFLP) is a rare but dramatic condition associated with a high maternal and fetal morbidity and mortality. We present a short review of AFLP management, illustrated by a case report. We conducted a systematic literature search for 'acute fatty liver of pregnancy', concerning its management. Read More

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Risk of recurrent acute fatty liver of pregnancy: survey from a social media group.

Am J Obstet Gynecol MFM 2020 05 9;2(2):100085. Epub 2020 Jan 9.

Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark.

Background: Acute fatty liver of pregnancy is a rare but serious complication in the last trimester of pregnancy or postpartum period. Data on the recurrence risk are largely unavailable, as only case reports or very small case series exist in which only 1 woman had recurrent acute fatty liver of pregnancy.

Objective: We aimed to estimate the risk of acute fatty liver of pregnancy recurrence and to compare disease severity and gestational age between primary and recurrent disease using patient-provided data from an acute fatty liver of pregnancy social media patient group. Read More

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Acute Kidney Injury in Pregnancy.

Adv Chronic Kidney Dis 2020 11;27(6):455-460

Department of Internal Medicine, Division of Nephrology Kidney C.A.R.E. Program, University of Cincinnati, Cincinnati, OH. Electronic address:

Acute kidney injury in pregnancy is a public health problem and a significant cause of maternal and fetal morbidity and mortality. The incidence of pregnancy-related acute kidney injury has increased in the developed countries, theorized to be the result of an increase in pregnancies in advanced maternal age, and continues to remain higher in developing countries owing to inadequate antenatal care. While hyperemesis gravidarum is a common cause of pregnancy-related acute kidney injury during the first trimester, complications such as preeclampsia, hemolysis, elevated liver enzymes, and low platelet count syndrome, acute fatty liver disease of pregnancy, thrombotic thrombocytopenic purpura, and hemolytic uremic syndrome are important causes of acute kidney injury later in the pregnancy. Read More

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November 2020

Missing or making the timely diagnosis of acute fatty liver of pregnancy (AFLP): lessons learned.

J Matern Fetal Neonatal Med 2020 Oct 9:1-7. Epub 2020 Oct 9.

Obstetrics and Gynecology, The Winfred L. Wiser Hospital for Women and Infants, The University of Mississippi Medical Center, Jackson, MS, USA.

Objective: To review the presenting signs, symptoms, laboratory findings, clinical courses, complications, and maternal outcomes in women determined on medicolegal review to have had acute fatty liver of pregnancy (AFLP).

Methods: We retrospectively studied case files from women with medical and/or hypertensive complications of pregnancy which had been reviewed by the first author, deidentified and divested of legal documents so that only medical-related information was retained for later research and teaching purposes. Main outcomes are 12 lessons learned from this review to be offered for the future benefit of clinicians encountering patients with AFLP. Read More

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October 2020

Potential predictors for prognosis and postpartum recovery time of acute fatty liver of pregnancy.

BMC Pregnancy Childbirth 2020 Oct 7;20(1):601. Epub 2020 Oct 7.

Department of Infectious Diseases, Xiangya Hospital, Central South University, Kaifu District, Xiangya Road 87, Changsha, 410008, China.

Background: Acute fatty liver of pregnancy (AFLP) is a potentially lethal condition of pregnant women with a high mortality rate. Potential predictors related to postpartum recovery time and prognostic factors of AFLP are still unclear. This study aimed to evaluate potential predictors for prognosis and postpartum recovery time of AFLP. Read More

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October 2020

Comparison of Standard Conservative Treatment and Early Initiation of Renal Replacement Therapy in Pregnancy-related Acute Kidney Injury: A Single-center Prospective Study.

Indian J Crit Care Med 2020 Aug;24(8):688-694

Department of Anesthesiology and Critical Care, Siddh Multispecialty Hospital, Moradabad, Uttar Pradesh, India.

Introduction And Objective: Pregnancy-related acute kidney injury (PRAKI) is one of the most important cause of maternal and fetal morbidity and mortality. Some of the reasons behind PRAKI may be due to sepsis, postpartum hemorrhage, preeclampsia, thrombotic microangiopathies (TMA), and acute fatty liver of pregnancy (AFLP). The timing of initiation of renal replacement therapy (RRT) for better patient outcome is still debatable. Read More

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Using Mitochondrial Trifunctional Protein Deficiency to Understand Maternal Health.

J Cell Signal 2020 ;1(3):97-101

Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.

Fatty acid oxidation disorders unfortunately can result in the sudden unexplained death of infants. Mitochondrial trifunctional protein (MTP) deficiency is one such disease where long-chain fatty acids cannot be fully oxidized through beta-oxidation which, can lead to cardiac arrythmias in an infant. Furthermore, mothers who are carrying an MTP deficient fetus have a prevalence for pregnancy complications, especially AFLP, acute fatty liver of pregnancy and HELLP syndrome. Read More

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January 2020

Identifying predictive factors for admitting patients with severe pre-eclampsia to intensive care unit.

J Matern Fetal Neonatal Med 2020 Sep 8:1-7. Epub 2020 Sep 8.

Department of Anesthesiology and Intensive Care, Nantes University Hospital, Nantes, France.

Background: Traditional obstetric units are inadequate for the level of monitoring required in pre-eclamptic patients. It remains to be determined which facility and tools should be implemented. The aim of this work was to identify predictive factors of admission to Intensive Care Unit (ICU) admissions for pregnancy-related hypertensive complications. Read More

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September 2020

Severe pre-eclampsia complicated by acute fatty liver disease of pregnancy, HELLP syndrome and acute kidney injury following SARS-CoV-2 infection.

BMJ Case Rep 2020 Aug 11;13(8). Epub 2020 Aug 11.

Obstetrics and Gynaecology, Birmingham Heartlands Hospital, Birmingham, West Midlands, UK.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has presented many diagnostic challenges and uncertainties. Little is known about common pathologies complicating pregnancy and how their behaviour is modified by the presence of SARS-CoV-2. Pregnancy itself can alter the body's response to viral infection, which can cause more severe symptoms. Read More

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Acute fatty liver of pregnancy cases in a maternal and child health hospital of China: Three case reports.

Medicine (Baltimore) 2020 Jul;99(29):e21110

Department of Obstetrics.

Rationale: Acute fatty liver of pregnancy (AFLP) is extremely hazardous to pregnant woman in the 3rd trimester of pregnancy. AFLP has an insidious onset and nonspecific experimental indicators, which therefore is difficult to be diagnosed.

Patient Concerns: Case 1 was transferred to our hospital for hypertensive disorders complicating pregnancy at gestation of 38 weeks + 3 days. Read More

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Indian National Association for the Study of the Liver Consensus Statement on Acute Liver Failure (Part 1): Epidemiology, Pathogenesis, Presentation and Prognosis.

J Clin Exp Hepatol 2020 Jul-Aug;10(4):339-376. Epub 2020 Apr 28.

Department of Hepatology and Gastroenterology, Fortis Escorts Liver & Digestive Diseases Institute (FELDI), Fortis Escorts Hospital, Delhi, India.

Acute liver failure (ALF) is an infrequent, unpredictable, potentially fatal complication of acute liver injury (ALI) consequent to varied etiologies. Etiologies of ALF as reported in the literature have regional differences, which affects the clinical presentation and natural course. In this part of the consensus article designed to reflect the clinical practices in India, disease burden, epidemiology, clinical presentation, monitoring, and prognostication have been discussed. Read More

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Maternal and neonatal outcomes and prognostic factors in acute fatty liver of pregnancy.

Eur J Obstet Gynecol Reprod Biol 2020 Sep 26;252:198-205. Epub 2020 Jun 26.

Laboratoire de Biochimie-Toxicologie, Hôpital Pontchaillou CHU Rennes, 2 rue Henri Le Guilloux, 35000, Rennes, France; Univ Rennes, CHU Rennes, INSERM, EHESP, IRSET (Institut de Recherche en Santé, Environnement et Travail) UMR_S 1085, F-35000, Rennes, France. Electronic address:

Objective: To report complications of Acute Fatty Liver of pregnancy (AFLP), a rare liver disease of pregnancy, and identify prognostic factors for mothers and children.

Study Design: We conducted a retrospective descriptive study over 18 years in three French maternities. Demographic, clinical, biological data, and outcomes of patients and their infants were reviewed. Read More

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September 2020

Acute Fatty Liver Disease of Pregnancy in the Second Trimester.

Case Rep Crit Care 2020 15;2020:6705784. Epub 2020 Jun 15.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, College of Medicine, University of Florida, 1600 SW Archer Road, P.O. Box 100225, Gainesville, FL 32610-0225, USA.

Acute fatty liver of pregnancy (AFLP) is a rare disorder that typically presents in the third trimester. We report a case of a 21-year-old woman with a history of intrauterine fetal demise at 19 weeks' gestation who developed fulminant liver failure 1 week after the fetal demise. She was diagnosed with AFLP as per the Swansea criteria. Read More

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Liver disease in pregnancy.

Hepatol Res 2020 Sep 13;50(9):1015-1023. Epub 2020 Jul 13.

Department of Obstetrics and Gynecology.

Development of liver diseases during pregnancy is not uncommon. They are caused by either a disorder that is unique to pregnancy or an acute or chronic liver disease that already exists or coincidentally develops as a comorbidity of pregnancy. Liver diseases unique to pregnancy include hyperemesis gravidarum; hypertensive disorders of pregnancy, such as pre-eclampsia/eclampsia; hemolysis, elevated liver enzymes, and low platelet count syndrome; intrahepatic cholestasis of pregnancy; and acute fatty liver of pregnancy. Read More

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September 2020

Risk factors assessment in patients with acute fatty liver of pregnancy treated without plasma exchange or renal replacement therapy.

J Matern Fetal Neonatal Med 2020 Jun 10:1-5. Epub 2020 Jun 10.

Department of Neurosurgery, Xuan Wu Hospital, Capital Medical University, Beijing, China.

Acute fatty liver of pregnancy(AFLP) is a rare but very urgent obstetric disease in clinical. It is a common cause of liver failure in pregnancy and often needs to be admitted to the department of critical care medicine because of the rapid development of acute hepatic dysfunction and severe acute renal dysfunction. The etiology and pathogenesis of this disorder is not very clear although there have been many studies on it before. Read More

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Severe HELLP syndrome masquerading as thrombocytopenic thrombotic purpura: a case report.

BMC Nephrol 2020 05 29;21(1):204. Epub 2020 May 29.

Department of Nephrology, CHU Tenon, Assistance Publique-Hopitaux de Paris, Paris, France.

Background: Thrombotic microangiopathies (TMAs) occurring in the postpartum period may be difficult to manage. They present as the combination of mechanical hemolytic anemia and consumption thrombocytopenia due to endothelial dysfunction. The cause of this endothelial aggression can be multiple: thrombocytopenic thrombotic purpura (TTP), HELLP syndrome, antiphospholipid syndrome, atypical hemolytic and uremic syndrome or acute fatty liver of pregnancy. Read More

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HELLP Syndrome or Acute Fatty Liver of Pregnancy: A Differential Diagnostic Challenge: Common Features and Differences.

Geburtshilfe Frauenheilkd 2020 May 18;80(5):499-507. Epub 2020 May 18.

Frauenklinik, Universitätsklinikum Erlangen, Erlangen, Germany.

HELLP syndrome and the less common acute fatty liver of pregnancy (AFL) are unpredictable, life-threatening complications of pregnancy. The similarities in their clinical and laboratory presentations are often challenging for the obstetrician when making a differential diagnosis. Both diseases are characterised by microvesicular steatosis of varying degrees of severity. Read More

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Thrombotic microangiopathy and pregnancy.

Ceska Gynekol 2020 ;85(1):18-28

Objective: The aim of this study is to draw attention to a nosological unit called thrombotic microangiopathy (TMA). This syndrome represents a serious pathological condition characterized by microangiopathic haemolytic anemia (MAHA), thrombocytopenia and various organ dysfunction. Patients are most often presented with symptoms of the HELLP syndrome but if the clinical picture is not restituted within 48-72 hours after delivery, other TMAs should be considered. Read More

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Pregnancy outcomes of patients with acute fatty liver of pregnancy: a case control study.

BMC Pregnancy Childbirth 2020 May 11;20(1):282. Epub 2020 May 11.

Department of Obstetrics and Gynecology, Beijing Youan Hospital, Capital Medical University, YouAn outer street No.8, Fengtai District, Beijing, 100006, China.

Background: Limited data exists regarding the pregnancy and infant outcomes of Acute Fatty Liver of Pregnancy (AFLP).

Methods: Retrospectively collected mothers with AFLP and mothers without AFLP in our center from 1/2008 to 6/2018. The primary assessment was to analyze and compare the frequency of negative maternal and fetal outcomes. Read More

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