597 results match your criteria Acute Fatty Liver of Pregnancy


Indian National Association for the Study of the Liver Consensus Statement on Acute Liver Failure (Part 1): Epidemiology, Pathogenesis, Presentation and Prognosis.

J Clin Exp Hepatol 2020 Jul-Aug;10(4):339-376. Epub 2020 Apr 28.

Institute of Liver & Digestive Diseases and Head of Hepatology & Liver Transplant (Medicine), BLK Super Speciality Hospital, Delhi, India.

Acute liver failure (ALF) is an infrequent, unpredictable, potentially fatal complication of acute liver injury (ALI) consequent to varied etiologies. Etiologies of ALF as reported in the literature have regional differences, which affects the clinical presentation and natural course. In this part of the consensus article designed to reflect the clinical practices in India, disease burden, epidemiology, clinical presentation, monitoring, and prognostication have been discussed. Read More

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http://dx.doi.org/10.1016/j.jceh.2020.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335721PMC

Maternal and neonatal outcomes and prognostic factors in acute fatty liver of pregnancy.

Eur J Obstet Gynecol Reprod Biol 2020 Jun 26;252:198-205. Epub 2020 Jun 26.

Laboratoire de Biochimie-Toxicologie, Hôpital Pontchaillou CHU Rennes, 2 rue Henri Le Guilloux, 35000, Rennes, France; Univ Rennes, CHU Rennes, INSERM, EHESP, IRSET (Institut de Recherche en Santé, Environnement et Travail) UMR_S 1085, F-35000, Rennes, France. Electronic address:

Objective: To report complications of Acute Fatty Liver of pregnancy (AFLP), a rare liver disease of pregnancy, and identify prognostic factors for mothers and children.

Study Design: We conducted a retrospective descriptive study over 18 years in three French maternities. Demographic, clinical, biological data, and outcomes of patients and their infants were reviewed. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.06.052DOI Listing

Acute Fatty Liver Disease of Pregnancy in the Second Trimester.

Case Rep Crit Care 2020 15;2020:6705784. Epub 2020 Jun 15.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, College of Medicine, University of Florida, 1600 SW Archer Road, P.O. Box 100225, Gainesville, FL 32610-0225, USA.

Acute fatty liver of pregnancy (AFLP) is a rare disorder that typically presents in the third trimester. We report a case of a 21-year-old woman with a history of intrauterine fetal demise at 19 weeks' gestation who developed fulminant liver failure 1 week after the fetal demise. She was diagnosed with AFLP as per the Swansea criteria. Read More

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http://dx.doi.org/10.1155/2020/6705784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315284PMC

Liver disease in pregnancy.

Hepatol Res 2020 Jun 24. Epub 2020 Jun 24.

Department of Obstetrics and Gynecology.

Development of liver diseases during pregnancy is not uncommon. They are caused by either a disorder that is unique to pregnancy or an acute or chronic liver disease that already exists or coincidentally develops as a comorbidity of pregnancy. Liver diseases unique to pregnancy include hyperemesis gravidarum; hypertensive disorders of pregnancy, such as pre-eclampsia/eclampsia; hemolysis, elevated liver enzymes, and low platelet count syndrome; intrahepatic cholestasis of pregnancy; and acute fatty liver of pregnancy. Read More

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http://dx.doi.org/10.1111/hepr.13540DOI Listing

Risk factors assessment in patients with acute fatty liver of pregnancy treated without plasma exchange or renal replacement therapy.

J Matern Fetal Neonatal Med 2020 Jun 10:1-5. Epub 2020 Jun 10.

Department of Neurosurgery, Xuan Wu Hospital, Capital Medical University, Beijing, China.

Acute fatty liver of pregnancy(AFLP) is a rare but very urgent obstetric disease in clinical. It is a common cause of liver failure in pregnancy and often needs to be admitted to the department of critical care medicine because of the rapid development of acute hepatic dysfunction and severe acute renal dysfunction. The etiology and pathogenesis of this disorder is not very clear although there have been many studies on it before. Read More

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http://dx.doi.org/10.1080/14767058.2020.1777267DOI Listing

Severe HELLP syndrome masquerading as thrombocytopenic thrombotic purpura: a case report.

BMC Nephrol 2020 May 29;21(1):204. Epub 2020 May 29.

Department of Nephrology, CHU Tenon, Assistance Publique-Hopitaux de Paris, Paris, France.

Background: Thrombotic microangiopathies (TMAs) occurring in the postpartum period may be difficult to manage. They present as the combination of mechanical hemolytic anemia and consumption thrombocytopenia due to endothelial dysfunction. The cause of this endothelial aggression can be multiple: thrombocytopenic thrombotic purpura (TTP), HELLP syndrome, antiphospholipid syndrome, atypical hemolytic and uremic syndrome or acute fatty liver of pregnancy. Read More

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http://dx.doi.org/10.1186/s12882-020-01865-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260815PMC

HELLP Syndrome or Acute Fatty Liver of Pregnancy: A Differential Diagnostic Challenge: Common Features and Differences.

Geburtshilfe Frauenheilkd 2020 May 18;80(5):499-507. Epub 2020 May 18.

Frauenklinik, Universitätsklinikum Erlangen, Erlangen, Germany.

HELLP syndrome and the less common acute fatty liver of pregnancy (AFL) are unpredictable, life-threatening complications of pregnancy. The similarities in their clinical and laboratory presentations are often challenging for the obstetrician when making a differential diagnosis. Both diseases are characterised by microvesicular steatosis of varying degrees of severity. Read More

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http://dx.doi.org/10.1055/a-1091-8630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234826PMC

Thrombotic microangiopathy and pregnancy.

Ceska Gynekol 2020 ;85(1):18-28

Objective: The aim of this study is to draw attention to a nosological unit called thrombotic microangiopathy (TMA). This syndrome represents a serious pathological condition characterized by microangiopathic haemolytic anemia (MAHA), thrombocytopenia and various organ dysfunction. Patients are most often presented with symptoms of the HELLP syndrome but if the clinical picture is not restituted within 48-72 hours after delivery, other TMAs should be considered. Read More

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Pregnancy outcomes of patients with acute fatty liver of pregnancy: a case control study.

BMC Pregnancy Childbirth 2020 May 11;20(1):282. Epub 2020 May 11.

Department of Obstetrics and Gynecology, Beijing Youan Hospital, Capital Medical University, YouAn outer street No.8, Fengtai District, Beijing, 100006, China.

Background: Limited data exists regarding the pregnancy and infant outcomes of Acute Fatty Liver of Pregnancy (AFLP).

Methods: Retrospectively collected mothers with AFLP and mothers without AFLP in our center from 1/2008 to 6/2018. The primary assessment was to analyze and compare the frequency of negative maternal and fetal outcomes. Read More

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http://dx.doi.org/10.1186/s12884-020-02980-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216501PMC

[Acute fatty liver of pregnancy in a Peruvian pregnant woman: a case report].

Rev Gastroenterol Peru 2020 Jan-Mar;40(1):80-84

Hospital "Víctor Lazarte Echegaray", EsSalud. Trujillo, Perú.

Acute fatty liver of pregnancy is a rare disease of pregnancy that occurs with greater preponderance during the third trimester. Its etiology is unknown, but there is evidence of a micro vesicular fat deposit in the hepatocyte. It has a maternal-fetal mortality up to 20% because the only treatment is to end gestation. Read More

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The interpretation of liver function tests in pregnancy.

Best Pract Res Clin Gastroenterol 2020 Feb - Apr;44-45:101667. Epub 2020 Feb 18.

Gastroenterology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy. Electronic address:

Abnormal liver tests occur in 3-5% of pregnancies and show many different causes. Although alterations of liver enzymes could be a physiological phenomenon, it may also reflect potential severe liver injury, necessitating further assessment and accurate management. The work-up has to consider liver diseases specific of pregnancy and non pregnancy-related liver damage (coincidental and pre-existing to pregnancy). Read More

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http://dx.doi.org/10.1016/j.bpg.2020.101667DOI Listing
February 2020

Comparing acute fatty liver of pregnancy from hemolysis, elevated liver enzymes, and low platelets syndrome.

J Matern Fetal Neonatal Med 2020 Apr 19:1-11. Epub 2020 Apr 19.

Department of Obstetrics and Gynecology, University of Texas, Southwestern Medical Center, Parkland Health and Hospital Systems, Dallas, TX, USA.

Acute fatty liver of pregnancy (AFLP) and hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome are both associated with significant maternal and perinatal morbidity and mortality. Because of the overlap of several clinical and laboratory findings differentiation can sometimes be difficult. Both disorders have been of interest for more than 100 years, however they were not completely characterized until the early 1980s. Read More

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http://dx.doi.org/10.1080/14767058.2020.1754790DOI Listing

Early diagnostic test for acute fatty liver of pregnancy: a retrospective case control study.

BMC Pregnancy Childbirth 2020 Mar 14;20(1):162. Epub 2020 Mar 14.

Department of Obstetrics and Gynecology, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, Hunan, 410011, People's Republic of China.

Background: Early diagnosis is important to lower the mortality rate of acute fatty liver of pregnancy (AFLP). The Swansea criteria is commonly used to diagnose AFLP, but some terms could only be reached when symptoms and signs have progressed, or are not efficient in clinical practice. Therefore, it is necessary to select cost effective tests to simplify and facilitate early suspicion of acute fatty liver of pregnancy. Read More

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http://dx.doi.org/10.1186/s12884-020-2787-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071771PMC

[Incidence and mortality risk factors of acute kidney injury in critical ill pregnancies: a single center retrospective analysis].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019 Dec;31(12):1506-1511

Department of ICU, Shandong University Affiliated Provincial Hospital, Jinan 250021, Shandong, China.

Objective: To evaluate the incidence and mortality risk factors of pregnancy-related acute kidney injury (PR-AKI) in intensive care unit (ICU).

Methods: A retrospective analysis was conducted. Critically ill pregnancies admitted to ICU of Shandong University Affiliated Provincial Hospital from January 1st, 2012 to December 31st, 2016 were enrolled. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2019.12.014DOI Listing
December 2019

A case of chronic hepatitis B merged with acute fatty liver of pregnancy with severe coagulopathy.

JA Clin Rep 2019 Jan 7;5(1). Epub 2019 Jan 7.

Department of Anesthesiology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Background: Acute fatty liver of pregnancy (AFLP) is a life-threatening disorder, and its relevance to viral hepatitis B (HB) remains unknown. This case presents an initial experience of treating a patient with HB progressing to AFLP throughout pregnancy; anesthesiologists should also recognize its clinical feature for perioperative management.

Case Presentation: A 28-year-old parturient was diagnosed as chronic HB (CHB) at 21 weeks gestation. Read More

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http://dx.doi.org/10.1186/s40981-018-0219-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967006PMC
January 2019

Liver Disease in Pregnancy: What's New.

Authors:
Carla W Brady

Hepatol Commun 2020 Feb 6;4(2):145-156. Epub 2020 Jan 6.

Division of Gastroenterology Duke University Medical Center Durham NC.

Liver disease in pregnancy may present as a disorder that is unique to pregnancy or as an acute or chronic liver disease occurring coincidentally in pregnancy. Hepatic diseases that are unique to pregnancy include hyperemesis gravidarum; preeclampsia/eclampsia; the syndrome of hemolysis, elevated liver enzymes, and low platelets; intrahepatic cholestasis of pregnancy; and acute fatty liver of pregnancy. Acute and chronic forms of primary hepatic disorders that are seen in pregnancy include viral hepatitis, autoimmune hepatitis, nonalcoholic fatty liver disease, and cirrhosis. Read More

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http://dx.doi.org/10.1002/hep4.1470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996303PMC
February 2020

Acute Fatty Liver of Pregnancy: Rare, but Potentially Fatal.

Am J Case Rep 2020 Jan 29;21:e921122. Epub 2020 Jan 29.

Obstetrics Service B, Bissaya Barreto Maternity, Coimbra University and Hospital Center, Coimbra, Portugal.

BACKGROUND Acute fatty liver of pregnancy is an obstetric emergency characterized by liver dysfunction, which can lead to severe maternal and fetal complications. CASE REPORT A 34-year-old woman, 37 weeks and 2 days pregnant, reported symptoms of nausea, vomiting, jaundice, and prostration. Laboratory findings revealed liver dysfunction and coagulopathy. Read More

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http://dx.doi.org/10.12659/AJCR.921122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006598PMC
January 2020

Acute Liver Failure (ALF) in Pregnancy: How Much Is Pregnancy-Related?

Hepatology 2020 Jan 28. Epub 2020 Jan 28.

Division of Digestive and Liver Diseases, UT Southwestern Medical Center at Dallas, Dallas, TX.

Background: Acute liver failure (ALF), characterized by sudden onset of coagulopathy (INR ≥ 1.5) and encephalopathy may occur during pregnancy, either as a pregnancy-associated etiology or as an unrelated and co-incidental liver injury. The U. Read More

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http://dx.doi.org/10.1002/hep.31144DOI Listing
January 2020

Fatty liver in pregnancy: a narrative review of two distinct conditions.

Expert Rev Gastroenterol Hepatol 2020 Feb 20;14(2):127-135. Epub 2020 Jan 20.

Department of Medical and Surgical Sciences, "Alma Mater" University, Sant'Orsola-Malpighi Hospital, Bologna, Italy.

: Fatty liver is rather common in pregnancy, occurring in two totally different conditions, i.e. nonalcoholic fatty liver disease (NAFLD) in pregnancy and acute fatty liver of pregnancy (AFLP). Read More

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http://dx.doi.org/10.1080/17474124.2020.1715210DOI Listing
February 2020

Liver Diseases in the Perinatal Period: Interactions Between Mother and Infant.

Hepatology 2020 Apr 18;71(4):1474-1485. Epub 2020 Mar 18.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO.

Liver diseases affecting the mother and infant dyad may present in the perinatal period from 20 weeks of gestation to 28 days of life. This review will focus on the current approach to neonatal acute liver failure and the progress made in the diagnosis and management of gestational alloimmune liver disease. It will highlight mother-to-child transmission of viral hepatitis, both management and public health implications. Read More

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http://dx.doi.org/10.1002/hep.31109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150638PMC

Acute Fatty Liver of Pregnancy From 18 Weeks' Gestation.

Hepatology 2020 Jun;71(6):2167-2169

Department of Obstetric Medicine, Cairns Hospital, Cairns, QLD, Australia.

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http://dx.doi.org/10.1002/hep.31090DOI Listing

Thrombocytopenia in pregnancy: Diagnosis and approach to management.

Blood Rev 2020 Mar 6;40:100638. Epub 2019 Nov 6.

Departments of Pathology and Laboratory Medicine and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Thrombocytopenia during pregnancy presents unique challenges for the hematologist. Obstetricians generally manage many of the pregnancy-specific etiologies, ranging from the benign (gestational thrombocytopenia) to the life-threatening (preeclampsia; hemolysis, elevated liver enzymes and low platelets syndrome; and acute fatty liver of pregnancy). However, hematologists may be consulted for atypical and severe presentations and to help manage non-pregnancy specific etiologies, including immune thrombocytopenia, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome and antiphospholipid syndrome, among others, in which maternal and fetal risks must be considered. Read More

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http://dx.doi.org/10.1016/j.blre.2019.100638DOI Listing

Acute Fatty Liver of Pregnancy.

Clin Obstet Gynecol 2020 Mar;63(1):152-164

Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Parkland Health and Hospital Systems, Dallas, Texas.

Acute fatty liver of pregnancy (AFLP) is a rare, but potentially fatal condition, characterized by hepatic failure typically in the third trimester of pregnancy that is associated with multiorgan involvement resulting in a number of clinical and laboratory abnormalities. The cornerstone of management of AFLP includes prompt recognition, preparation for delivery, and supportive care such as reversal of coagulopathy. Early diagnosis, prompted delivery, and supportive care have resulted in improved maternal morbidity and mortality. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000494DOI Listing

Changing epidemiology of acute kidney injury in pregnancy: A journey of four decades from a developing country.

Saudi J Kidney Dis Transpl 2019 Sep-Oct;30(5):1118-1130

Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

The incidence of acute kidney injury in pregnancy (P-AKI) has markedly decreased over the last three decades in India, particularly due to decreased incidence of postabortion AKI. However, P-AKI still accounts for 3%-5% of cases of total AKI. Postabortion sepsis has decreased to between 0. Read More

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http://dx.doi.org/10.4103/1319-2442.270268DOI Listing

Angiogenic markers are elevated in women with acute fatty liver of pregnancy.

Ultrasound Obstet Gynecol 2019 Nov 4. Epub 2019 Nov 4.

Department of Internal Medicine, Division of Pharmacology and Vascular Medicine, Erasmus Medical Center Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/uog.21912DOI Listing
November 2019

[Analysis of changes in clinical characteristics and laboratory indexes of 54 cases of acute fatty liver of pregnancy].

Authors:
M Zhou X D Luo Y Yang

Zhonghua Gan Zang Bing Za Zhi 2019 Aug;27(8):638-642

Department of Obstetrics and Gynecology, Hospital of Chongqing Red Cross Society(People's Hospital of Jiangbei District), Chongqing 400020, China.

To investigate the changes in clinical characteristics and laboratory indexes before and after the termination of pregnancy in patients with acute fatty liver of pregnancy (AFLP). Patients with acute fatty liver of pregnancy who had been admitted to the Department of Obstetrics and Gynecology at the Second Affiliated Hospital of Chongqing Medical University and Chongqing Municipal People's Hospital of Jiangbei District between 2007 and 2018 were selected. Clinical characteristics and complications during diagnosis and treatment, changes in blood coagulation, liver and kidney function, and postpartum recovery were collected for retrospectively analysis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1007-3418.2019.08.010DOI Listing
August 2019
2 Reads

Acute kidney injury in pregnancy.

Curr Opin Crit Care 2019 12;25(6):580-590

Division of Nephrology, Department of Medicine, Jacobi Medical Center at Albert Einstein College of Medicine, Bronx, New York, USA.

Purpose Of Review: Pregnancy-related acute kidney injury (Pr-AKI) is associated with increased maternal and fetal morbidity and mortality and remains a large public health problem.

Recent Findings: Pr-AKI incidence has globally decreased over time for the most part. However, the cause presents a disparity between developing and developed countries, reflecting differences in socioeconomic factors and healthcare infrastructure - with the noteworthy outlier of increased incidence in the United States and Canada. Read More

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http://Insights.ovid.com/crossref?an=00075198-900000000-9906
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http://dx.doi.org/10.1097/MCC.0000000000000656DOI Listing
December 2019
5 Reads

Acute fatty liver of pregnancy in a Chinese Tertiary Care Center: a retrospective study.

Arch Gynecol Obstet 2019 10 21;300(4):897-901. Epub 2019 Aug 21.

Department of Obstetrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Purpose: To describe some prenatal clinical features and laboratory findings of AFLP and provide the clinicians with potential predictors in postpartum recovery time.

Methods: Forty-four cases of AFLP previously treated in the First Affiliated Hospital of Zhengzhou University were retrospectively reviewed.

Results: The maternal and fetal mortalities after treatment were both 18. Read More

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http://dx.doi.org/10.1007/s00404-019-05259-wDOI Listing
October 2019
2 Reads

Indian National Association for the Study of the Liver-Federation of Obstetric and Gynaecological Societies of India Position Statement on Management of Liver Diseases in Pregnancy.

J Clin Exp Hepatol 2019 May-Jun;9(3):383-406. Epub 2019 Mar 6.

BLK Super Speciality Hospital, New Delhi, India.

Liver diseases occurring during pregnancy can be serious and can progress rapidly, affecting outcomes for both the mother and fetus. They are a common cause of concern to an obstetrician and an important reason for referral to a hepatologist, gastroenterologist, or physician. Liver diseases during pregnancy can be divided into disorders unique to pregnancy, those coincidental with pregnancy, and preexisting liver diseases exacerbated by pregnancy. Read More

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http://dx.doi.org/10.1016/j.jceh.2019.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637074PMC
March 2019
22 Reads

Acute fatty liver of pregnancy: a case report.

BMC Pregnancy Childbirth 2019 Jul 22;19(1):259. Epub 2019 Jul 22.

Department of Histopathology, University of Zimbabwe, College of Health Sciences, Harare, Zimbabwe.

Background: Acute Fatty Liver of Pregnancy (AFLP) is a rare, catastrophic disease affecting women in the third trimester of pregnancy or in the post-partum period. It is usually a diagnosis of exclusion and requires a strong index of suspicion for a timely diagnosis and prompt intervention.

Case Presentation: We report a case of AM, an 18 year patient, in her first pregnancy at 35 weeks gestation who presented with nausea, vomiting and jaundice. Read More

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http://dx.doi.org/10.1186/s12884-019-2405-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647299PMC
July 2019
3 Reads

Severe fatty liver of pregnancy requiring an extremely large amount of blood transfusion, surgery and transarterial embolization: A case report.

Case Rep Womens Health 2019 Jul 13;23:e00130. Epub 2019 Jun 13.

Department of Obstetrics and Gynecology, Kindai University, Faculty of Medicine, Japan.

We report a case of massive bleeding due to a coagulation disorder associated with acute fatty liver of pregnancy (AFLP); the patient survived by massive transfusion. She presented at 34 weeks of gestation, met six of the Swansea criteria, and was diagnosed with severe AFLP. We performed an emergency cesarean section because termination of the pregnancy was necessary for the treatment of the AFLP. Read More

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http://dx.doi.org/10.1016/j.crwh.2019.e00130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599870PMC
July 2019
3 Reads

Utility of MELD scoring system for assessing the prognosis of acute fatty liver of pregnancy.

Eur J Obstet Gynecol Reprod Biol 2019 Sep 29;240:161-166. Epub 2019 Jun 29.

Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. Electronic address:

Objective: To evaluate the value of Model for end-stage liver disease (MELD) in assessing the prognosis of acute fatty liver of pregnancy (AFLP).

Study Design: This was a retrospective study. From January 2010 to July 2018, data of 53 women diagnosed with AFLP in the third affiliated hospital of Sun Yat-Sen University were collected. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.06.030DOI Listing
September 2019
6 Reads

Severe haematuria: an atypical cause of near miss in a woman with acute fatty liver of pregnancy.

J Obstet Gynaecol 2019 Nov 19;39(8):1169-1170. Epub 2019 Jun 19.

Department of Hepatology, Post Graduate Institute of Medical Education and Research , Chandigarh , India.

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http://dx.doi.org/10.1080/01443615.2019.1592128DOI Listing
November 2019
18 Reads

Liver disease in pregnancy: Medical aspects and their implications for mother and child.

Ann Hepatol 2019 Jul - Aug;18(4):553-562. Epub 2019 May 6.

Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.

Liver disease during pregnancy is more common than expected and may require specialized intervention. It is important to determine if changes in liver physiology may develop into liver disease, to assure early diagnosis. For adequate surveillance of mother-fetus health outcome, liver disease during pregnancy might require intervention from a hepatologist. Read More

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http://dx.doi.org/10.1016/j.aohep.2019.04.009DOI Listing
May 2019
12 Reads

Outcomes of liver transplantation for acute fatty liver disease of pregnancy.

Am J Transplant 2019 07 16;19(7):2101-2107. Epub 2019 May 16.

University of California San Francisco, San Francisco, California.

Acute fatty liver of pregnancy (AFLP) often resolves after pregnancy delivery but can progress to acute liver failure necessitating liver transplantation. We performed a retrospective review of the national Scientific Registry of Transplant Recipients (SRTR) data to identify all women in the United States undergoing liver transplantation (LT) for acute liver failure (ALF) from AFLP from 1991 to 2015, and compared to outcomes in women of childbearing age undergoing transplant for ALF from acetaminophen and ALF from other etiologies. Women with AFLP were likely to be on life support at time of LT and had high rates of renal dysfunction (median Cr 2. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.15401
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http://dx.doi.org/10.1111/ajt.15401DOI Listing
July 2019
27 Reads

Liver Diseases During Pregnancy.

Clin Liver Dis 2019 05 26;23(2):345-361. Epub 2019 Feb 26.

Section of Hepatology, Division of Digestive Diseases, Department of Internal Medicine, Rush University Medical Center, 1725 West Harrison Street, Suite 319, Chicago, IL 60612, USA. Electronic address:

Liver diseases during pregnancy pose a unique clinical challenge because they can affect the lives of both the mother and unborn child. Although severe liver disease is rare, pregnancy-related liver disease affects approximately 3% of pregnancies and can be fatal. Timely recognition and diagnosis are essential in order to institute appropriate management strategies. Read More

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http://dx.doi.org/10.1016/j.cld.2018.12.013DOI Listing
May 2019
29 Reads

An Observational Study to Evaluate the Maternal and Foetal Outcomes in Pregnancies Complicated with Jaundice.

J Obstet Gynaecol India 2019 Feb 22;69(1):31-36. Epub 2018 Mar 22.

Department of Obstetrics and Gynaecology, Lokmanya Tilak Municipal Medical College, Sion, Mumbai, 400022 India.

Background: Incidence of jaundice in pregnancy, including underlying chronic liver diseases, is 3-5%. However, the maternal mortality rate in some conditions can be as high as 18% in acute fatty liver of pregnancy and 22% in hepatitis E in pregnancy.

Objectives: This is an observational study of the demographics, obstetrical profile, aetiology, maternal morbidity, mortality and neonatal outcomes in pregnancies complicated with jaundice. Read More

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http://dx.doi.org/10.1007/s13224-018-1105-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361180PMC
February 2019
33 Reads

Acute Fatty Liver of Pregnancy: Pathophysiology, Anesthetic Implications, and Obstetrical Management.

Anesthesiology 2019 03;130(3):446-461

From the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (E.E.N., L.R.L., H.V.C.) the Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine (K.J.G.) the Department of Anesthesiology, Perioperative and Pain Medicine (B.T.B.) the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine (B.T.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1097/ALN.0000000000002597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037575PMC
March 2019
20 Reads

[Acute fatty liver of pregnancy].

Ned Tijdschr Geneeskd 2019 01 14;162. Epub 2019 Jan 14.

Ziekenhuis Gelderse Vallei, afd. Gynaecologie & Verloskunde, Ede.

Background: Acute fatty liver of pregnancy (AFLP) is a rare complication of pregnancy which is potentially fatal to mother and child.

Case Description: A primigravida at term with gestational diabetes presented at hospital complaining mainly of nausea and vomiting. Test results were consistent with acute fatty liver of pregnancy (AFLP). Read More

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January 2019
38 Reads

Immune thrombocytopenic purpura presenting with spontaneous gingival haemorrhage in pregnancy.

BMJ Case Rep 2019 Jan 17;12(1). Epub 2019 Jan 17.

Department of Oral and Maxillofacial Surgery, The Queen Elizabeth Hospital, Birmingham, UK.

Gingival bleeding is a common intraoral finding, typically associated with inflamed tissues and periodontal disease. It is easily provoked by periodontal probing or toothbrushing. Spontaneous gingival bleeding rarely occurs and may be the only sign of systemic bleeding problems such as thrombocytopenia, leukaemia or coagulopathy. Read More

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http://dx.doi.org/10.1136/bcr-2018-228309DOI Listing
January 2019
26 Reads

Acute fatty liver of pregnancy and concomitant medical conditions: A review of cases at a quaternary obstetric hospital.

Obstet Med 2018 Dec 5;11(4):178-181. Epub 2018 Jun 5.

Faculty of Medicine, University of Queensland, Brisbane, Australia.

Acute fatty liver of pregnancy is a rare complication of pregnancy that may result in fulminant hepatic failure. We present a review of all patients presenting to a quaternary obstetric hospital over a 15-year period, with particular regard to biochemical changes, results of gene testing, and pre-existing conditions. Seventeen patients with acute fatty liver of pregnancy were identified. Read More

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http://dx.doi.org/10.1177/1753495X18764816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295769PMC
December 2018
19 Reads

Readiness, Recognition, Response, and Reporting in a Case of Acute Fatty Liver of Pregnancy.

Authors:
Jane Ciaramella

Nurs Womens Health 2018 Dec 28;22(6):481-488. Epub 2018 Oct 28.

Acute fatty liver of pregnancy (AFLP) occurs less frequently than similarly challenging complications in pregnancy. Early recognition is key to reduce morbidity and mortality. Women present with symptoms common to many illnesses, and AFLP typically occurs in the third trimester. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17514851183019
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http://dx.doi.org/10.1016/j.nwh.2018.09.003DOI Listing
December 2018
32 Reads

A successful use of therapeutic plasma exchange in a fulminant form of acute fatty liver of pregnancy.

J Gynecol Obstet Hum Reprod 2019 Feb 11;48(2):133-137. Epub 2018 Oct 11.

Department of Anesthesia & Intensive Care Medicine, Medical School of Marrakech (Cadi Ayyad University), Mother & Child Hospital, Mohammed VI Teaching Hospital, Marrakech, Morocco.

Acute fatty liver of pregnancy (AFLP) continues to raise special concerns since its first post-mortem description by Sheehan in 1940. While early diagnosis and expedite delivery are the cornerstone of management, this condition remains fatal for both mother and fetus. Acute fulminant liver failure is the most serious and life-threatening AFLP-related complication and can require liver transplant despite aggressive supportive management. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24687847183024
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http://dx.doi.org/10.1016/j.jogoh.2018.10.001DOI Listing
February 2019
8 Reads

Treating acute fatty liver of pregnancy with artificial liver support therapy: Systematic review.

Medicine (Baltimore) 2018 Sep;97(38):e12473

Department of Infectious Diseases, The First Affiliated Hospital of Nanchang University.

Background: Acute fatty liver of pregnancy (AFLP) is a serious disease with high mortality. Recent data suggest that postpartum application of artificial liver support therapy (ALST) in AFLP management improves disease outcome. In current study, we tend to further evaluate whether the type, the timing, and the number of postpartum ALST sessions and other clinical factors including complications and liver and renal function will influence disease outcome in ALST era. Read More

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http://dx.doi.org/10.1097/MD.0000000000012473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160087PMC
September 2018
13 Reads

Acute fatty liver of pregnancy in a woman with ulcerative colitis and familial hidradenitis suppurativa.

Authors:
Adam Morton

Obstet Med 2018 Sep 19;11(3):141-143. Epub 2017 Nov 19.

Obstetric Medicine, University of Queensland, Queensland, Australia.

Acute fatty liver of pregnancy is a heterogeneous disorder which may occur in the absence of a detectable gene mutation for the enzyme long-chain L-3-hydroxyacyl-CoA dehydrogenase. Acute fatty liver of pregnancy has been reported to complicate several gastrointestinal disorders including viral hepatitis, chronic active hepatitis and intrahepatic cholestasis of pregnancy. A case of acute fatty liver of pregnancy in a woman with ulcerative colitis and familial hidradenitis suppurativa without a detectable gene mutation is presented. Read More

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http://dx.doi.org/10.1177/1753495X17736716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134355PMC
September 2018
10 Reads

Physiological changes of pregnancy and the Swansea criteria in diagnosing acute fatty liver of pregnancy.

Obstet Med 2018 Sep 16;11(3):126-131. Epub 2018 Apr 16.

Mater Health, University of Queensland, Brisbane, Australia.

The Swansea criteria are used to assess the likelihood of acute fatty liver of pregnancy. There are significant physiological changes in normal pregnancy in several of the pathology parameters used in the Swansea criteria. This may impact the sensitivity and specificity of the Swansea criteria. Read More

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http://dx.doi.org/10.1177/1753495X18759353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134352PMC
September 2018
10 Reads

Transversus Abdominis Plane Block With Ilioinguinal-Iliohypogastric Nerve a Viable Alternative to Provide Surgical Anesthesia for Cesarean Delivery: A Case Report.

A A Pract 2019 Mar;12(6):185-186

Anaesthesia, Lady Hardinge Medical College, New Delhi, India.

Acute fatty liver of pregnancy is one of the most common causes of fulminant hepatic failure. A 28-year-old G3P1L1A1 presented at 37 weeks with diagnosis of acute fatty liver of pregnancy with grade 3 hepatic encephalopathy. Laboratory findings were suggestive of coagulopathy, metabolic acidosis, and liver and renal dysfunction. Read More

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http://Insights.ovid.com/crossref?an=02054229-900000000-9979
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http://dx.doi.org/10.1213/XAA.0000000000000875DOI Listing
March 2019
18 Reads

Markedly higher sFlt-1/PlGF ratio in a woman with acute fatty liver of pregnancy compared with HELLP syndrome.

J Obstet Gynaecol Res 2019 Jan 23;45(1):96-103. Epub 2018 Aug 23.

Department of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Tochigi, Japan.

Aim: To compare serum levels of angiogenesis-related factors between 14 women with HELLP (hemolysis, elevated liver enzymes and low platelet count) syndrome and a woman with acute fatty liver of pregnancy (AFLP).

Methods: Serum samples were collected in 2004-2008 and 2013-2016. The levels of soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) were measured by an automated electrochemiluminescence immunoassay using Elecsys sFlt-1 and Elecsys PlGF. Read More

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http://dx.doi.org/10.1111/jog.13786DOI Listing
January 2019
30 Reads