39,283 results match your criteria Acute Coronary Syndromes


Acute coronary syndrome in the time of the COVID-19 pandemic.

Eur Heart J 2020 Jun 4. Epub 2020 Jun 4.

Wayne State University, Detroit Medical Center, Detroit, MI, USA.

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http://dx.doi.org/10.1093/eurheartj/ehaa454DOI Listing

A current review of COVID-19 for the cardiovascular specialist.

Am Heart J 2020 May 3;226:29-44. Epub 2020 May 3.

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Critical Care Cardiology Section, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Electronic address:

Although coronavirus disease 2019 (COVID-19) predominantly disrupts the respiratory system, there is accumulating experience that the disease, particularly in its more severe manifestations, also affects the cardiovascular system. Cardiovascular risk factors and chronic cardiovascular conditions are prevalent among patients affected by COVID-19 and associated with adverse outcomes. However, whether pre-existing cardiovascular disease is an independent determinant of higher mortality risk with COVID-19 remains uncertain. Read More

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http://dx.doi.org/10.1016/j.ahj.2020.04.025DOI Listing

Recurrent Lethal Allergic Coronary Vasospasm.

Am J Med 2020 Jun 1. Epub 2020 Jun 1.

Department of Medicine, University of Florida, Gainesville, Florida; Division of Cardiology, University of Florida, Gainesville, Florida. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2020.04.037DOI Listing

[Spontaneous coronary artery dissection : primum nihil nocere].

Rev Med Suisse 2020 Jun;16(696):1153-1158

Service de cardiologie, HUG, 1211 Genève 14.

Spontaneous coronary artery dissection (SCAD) is an important cause of acute coronary syndrome, myocardial infarction and sudden cardiac death, among young patient with little/no traditional cardiovascular risk factors. Historically SCAD was considered as a rare pathology, associated primarily with pregnancy and the peripartum period. In recent years, SCAD diagnosis improved thanks to data derived from large registries, thanks to the increased use of diagnostic coronary angiography and the availability of intracoronary imaging. Read More

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Measurement of novel adipokine visfatin in young patients with acute myocardial infarction. Clinical testing of a new ELISA.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2020 Jun 1. Epub 2020 Jun 1.

Institute of Laboratory Diagnostics, University Hospital Ostrava, Czech Republic.

Objectives: Adipose tissue produces a number of adipokines that have metabolic effect. Visfatin is a recently discovered adipokine whose concentration in plasma increases in obesity. It is also a proinflammatory mediator that promotes atherosclerosis and plays a role in plaque destabilization. Read More

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http://dx.doi.org/10.5507/bp.2020.024DOI Listing

Renal artery intervention for a patient with flash pulmonary edema accompanied by elevation of troponin levels due to bilateral renal artery stenosis and multivessel coronary disease: a case report.

J Int Med Res 2020 Jun;48(6):300060520926032

Department of Cardiology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong, China.

An 84-year-old woman complaining of acute-onset chest distress for 2 hours was referred to the Department of Cardiology, Guangzhou Red Cross Hospital, China. A physical examination showed signs of acute pulmonary edema with considerably elevated blood pressure of 186/120 mmHg. An electrocardiogram showed ST segment depression in leads I, II, and III, and from V4 to V6. Read More

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http://dx.doi.org/10.1177/0300060520926032DOI Listing

[Is FFR a game changer in coronary CT angiography?]

Herz 2020 Jun 3. Epub 2020 Jun 3.

Abteilung für Diagnostische und Interventionelle Radiologie / Professur für Kardiologische Bildgebung, Herzzentrum Leipzig - Universität Leipzig, Strümpellstraße 39, 04289, Leipzig, Deutschland.

Coronary computed tomography angiography (CCTA) is already of great importance for the primary diagnostic testing for coronary artery disease (CAD) due to its high negative predictive value (NPV) and high sensitivity but, however, limited specificity. The specificity of invasive coronary angiography (ICA) could be increased by integrating the fractional flow reserve (FFR) into the invasive workflow with proof of the hemodynamic relevance of a morphologically detected coronary stenosis. New noninvasive methods of FFR calculations in CT based on computational fluid dynamics (CFD) or machine learning (ML) demonstrate very encouraging results; however, the widespread use of FFR is mainly determined by the image quality and the resulting capabilities of coronary artery segmentation, which could be insufficient in up to 7-12% of CCTAs to calculate FFR, although a morphological assessment is still possible in most cases. Read More

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http://dx.doi.org/10.1007/s00059-020-04944-wDOI Listing

31 days of COVID-19-cardiac events during restriction of public life-a comparative study.

Clin Res Cardiol 2020 Jun 3. Epub 2020 Jun 3.

Clinic for Internal Medicine II, University Hospital Ulm-Medical Center, Albert Einstein Allee 23, 89081, Ulm, Germany.

Aims: The coronavirus SARS-CoV-2 outbreak led to the most recent pandemic of the twenty-first century. To contain spread of the virus, many nations introduced a public lockdown. How the pandemic itself and measures of social restriction affect hospital admissions due to acute cardiac events has rarely been evaluated yet. Read More

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http://dx.doi.org/10.1007/s00392-020-01681-2DOI Listing

Aggressive Endocarditis in a Young Healthy Patient: A Case Report.

Cardiol Res 2020 Jun 3;11(3):192-195. Epub 2020 May 3.

Department of Medicine, Jersey Shore University Medical Center, Hackensack Meridian Health, Neptune, NJ 07753, USA.

() is a β-hemolytic coagulase-negative staphylococcus causing skin and soft tissue infections with an increasing incidence. Commonly found as normal flora in the perineal region, has been found in rare cases of infective endocarditis causing increased morbidity and mortality. We present a case of a previously healthy young male diagnosed with -caused infective endocarditis. Read More

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http://dx.doi.org/10.14740/cr1037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239590PMC

Identification of risk factors of acute coronary syndrome in young patients between 18-40 years of age at a teaching hospital.

Pak J Med Sci 2020 May-Jun;36(4):821-824

Zubair Akram. FACA, FCPS (Cardiology).Professor and Head, Department of Cardiology, Jinnah Hospital, Allama Iqbal Medical College, Lahore, Pakistan.

Objectives: To identify the risk factors in acute coronary syndrome.

Methods: It was a case series study, conducted in coronary care unit of Jinnah Hospital, Lahore from January to December 2018. Convenient sampling was used for patients' selection. Read More

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http://dx.doi.org/10.12669/pjms.36.4.2302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260892PMC

Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study.

BMJ 2020 Jun 3;369:m2094. Epub 2020 Jun 3.

Department of General Paediatrics and Paediatric Infectious Diseases, Necker-Enfants Malades University Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Université de Paris, 149 rue de Sèvres, 75015 Paris, France.

Objectives: To describe the characteristics of children and adolescents affected by an outbreak of Kawasaki-like multisystem inflammatory syndrome and to evaluate a potential temporal association with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Design: Prospective observational study.

Setting: General paediatric department of a university hospital in Paris, France. Read More

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http://dx.doi.org/10.1136/bmj.m2094DOI Listing

Alogliptin after acute coronary syndrome in patients with type 2 diabetes: a renal function stratified analysis of the EXAMINE trial.

BMC Med 2020 Jun 4;18(1):165. Epub 2020 Jun 4.

Université de Lorraine, Centre d'Investigations Cliniques Plurithématique Inserm 1433, Nancy, France, CHRU de Nancy, Inserm U1116, Nancy, France, FCRIN INI-CRCT, Nancy, France.

Background: The EXAMINE trial tested the efficacy and safety of alogliptin, an inhibitor of dipeptidyl peptidase 4, compared with placebo in 5380 patients with type 2 diabetes and a recent acute coronary syndrome. Because alogliptin is cleared by the kidney, patients were stratified according to screening renal function within two independently randomized strata: (1) estimated glomerular filtration rate (eGFR) ≥ 60 ml/min/1.73m and (2) eGFR < 60 ml/min/1. Read More

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http://dx.doi.org/10.1186/s12916-020-01616-8DOI Listing

Identification of a miRNA Based-Signature Associated with Acute Coronary Syndrome: Evidence from the FLORINF Study.

J Clin Med 2020 Jun 1;9(6). Epub 2020 Jun 1.

Institute of Metabolic and Cardiovascular Diseases, INSERM UMR-1048, 31432 Toulouse, France.

Background: The discovery of novel biomarkers that improve risk prediction models of acute coronary syndrome (ACS) is needed to better identify and stratify very high-risk patients. MicroRNAs (miRNAs) are essential non-coding modulators of gene expression. Circulating miRNAs recently emerged as important regulators and fine-tuners of physiological and pathological cardiovascular processes; therefore, specific miRNAs expression profiles may represent new risk biomarkers. Read More

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http://dx.doi.org/10.3390/jcm9061674DOI Listing

P2Y12 Inhibitor Monotherapy with Clopidogrel Versus Ticagrelor in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.

J Clin Med 2020 Jun 1;9(6). Epub 2020 Jun 1.

Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.

Background: P2Y12 inhibitor monotherapy is an alternative antiplatelet strategy in patients undergoing percutaneous coronary intervention (PCI). However, the ideal P2Y12 inhibitor for monotherapy is unclear.

Methods And Results: We performed a multicenter, retrospective, observational study to compare the efficacy and safety of monotherapy with clopidogrel versus ticagrelor in patients with acute coronary syndrome (ACS) undergoing PCI. Read More

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http://dx.doi.org/10.3390/jcm9061657DOI Listing

Exploring the complex interactions of baseline patient factors to improve nursing triage of acute coronary syndrome.

Res Nurs Health 2020 Jun 3. Epub 2020 Jun 3.

Department of Acute and Tertiary Care, University of Pittsburgh School of Nursing, Pittsburgh, Pennsylvania.

Emergency department (ED) nurses need to identify patients with potential acute coronary syndrome (ACS) rapidly because treatment delay could impact patient outcomes. Aims of this secondary analysis were to identify key patient factors that could be available at initial ED nurse triage that predict ACS. Consecutive patients with chest pain who called 9-1-1, received a 12-lead electrocardiogram in the prehospital setting, and were transported via emergency medical service were included in the study. Read More

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http://dx.doi.org/10.1002/nur.22045DOI Listing

Role of Interleukin-18 and the Thrombus Precursor Protein in Coronary Artery Disease.

Arq Bras Cardiol 2020 Apr 29;114(4):692-698. Epub 2020 May 29.

Fundação Pró Coração, Rio de Janeiro, RJ, Brasil.

Background Coronary failure is the leading cause of death worldwide and identifying patients at higher risk for coronary artery disease (CAD) is a challenge. Objectives To test the biomarkers interleukin 18 (IL-18) and thrombus precursor protein (TpP), involved in atherogenesis, to aid in the early assessment of CAD. Methods This was a cross-sectional cohort of 119 patients, stratified into three groups: Group I - acute coronary syndrome (39); Group II - chronic CAD (40) and Group III - control, without coronary lesion, but who might have risk factors for CAD (40). Read More

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http://dx.doi.org/10.36660/abc.20190176DOI Listing

Baseline characteristics predicting clinical outcomes and serious adverse events in middle-aged hypertensive women: a sub-analysis of the SPRINT in women aged <65 years.

Turk J Med Sci 2020 Jun 3. Epub 2020 Jun 3.

Background/aim: The predictability of clinical outcomes in hypertension in specific patient groups, especially underrepresented populations is the key to rational treatment. This study aimed to investigate the impact of baseline characteristics of <65-year-old hypertensive women with an increased risk of cardiovascular events, managed with standard- or intensive-approach, on their clinical outcomes and serious adverse events (SAEs).

Materials And Methods: Baseline characteristics of <65-year-old hypertensive women (n=1247) in SPRINT, a multicenter randomized trial to compare standard and intensive antihypertensive treatment, were analyzed with Cox-regression method to determine potential predictors of the clinical outcomes and SAEs. Read More

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http://dx.doi.org/10.3906/sag-1907-144DOI Listing

Incremental Prognostic Value of Anemia in Acute Coronary Syndrome from A Rural Hospital in India.

Glob Heart 2020 Feb 12;15(1):16. Epub 2020 Feb 12.

Lata Medical Research Foundation, Nagpur, IN.

Background: Anemia is highly prevalent in low- and middle-income countries, where prevalence of acute coronary syndrome (ACS) is also rising. Evidence indicates that baseline anemia status can prognosticate ACS. However, the Global Registry of Acute Coronary Events (GRACE) score that is popularly used all over the world does not include information on anemia. Read More

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http://dx.doi.org/10.5334/gh.527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218781PMC
February 2020

Patterns of Emergency Care for Possible Acute Coronary Syndrome Among Patients with Chest Pain or Shortness of Breath at a Tanzanian Referral Hospital.

Glob Heart 2020 Feb 6;15(1). Epub 2020 Feb 6.

Department of Emergency Medicine, Kilimanjaro Christian Medical Centre, Moshi, TZ.

Background: Acute coronary syndrome (ACS) is thought to be a rare diagnosis in sub-Saharan Africa, but little is known about diagnostic practices for patients with possible ACS symptoms in the region.

Objective: To describe current care practices for patients with ACS symptoms in Tanzania to identify factors that may contribute to ACS under-detection.

Methods: Emergency department patients with chest pain or shortness of breath at a Tanzanian referral hospital were prospectively observed. Read More

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http://dx.doi.org/10.5334/gh.402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218785PMC
February 2020

Association between Adherence to Guideline-Recommended Preventive Medications and In-Hospital Mortality among Non-Reperfused ST-Elevation Myocardial Infarction Patients Admitted to a Tertiary Care Academic Center in a Developing Country.

Glob Heart 2020 Feb 6;15(1). Epub 2020 Feb 6.

University of Groningen, Groningen Research Institute of Pharmacy, PharmacoTherapy, -Epidemiology and -Economics, Groningen, NL.

Background And Aims: Acute ST-elevation myocardial infarction (STEMI) is a potentially fatal presentation of coronary artery disease (CAD). Evidence of the impact of acute pharmacological interventions in non-reperfused STEMI patients on subsequent events is limited. We aimed to assess the association between adherence to guideline-recommended preventive medications and in-hospital mortality among this high-risk patient population. Read More

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http://dx.doi.org/10.5334/gh.394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218801PMC
February 2020

Circulating metabolites from the choline pathway and acute coronary syndromes in a Chinese case-control study.

Nutr Metab (Lond) 2020 24;17:39. Epub 2020 May 24.

Department of Cardiology, Shanghai Institute of Cardiovascular Disease, ZhongShan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032 China.

Background: Accumulating evidence shows that circulating levels of trimethylamine N-oxide, which is generated from the metabolism of dietary choline, may predict cardiovascular disease among Caucasians. Acute coronary syndrome (ACS), one common presentation of cardiovascular disease, is a spectrum of signs and symptoms due to acute decreased blood flow in the coronary arteries. The relationship between the metabolites from choline pathway and ACS remains unclear. Read More

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http://dx.doi.org/10.1186/s12986-020-00460-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245747PMC

Long-Term Clinical Outcomes for Non-ST Elevation Acute Coronary Syndrome Patients with High-Risk Angiographic Findings Undergoing Percutaneous Coronary Intervention.

J Interv Cardiol 2020 7;2020:2139617. Epub 2020 May 7.

Fu Wai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.

Objective: We aim to evaluate the long-term prognosis of non-ST elevation acute coronary syndrome (NSTE-ACS) patients with high-risk coronary anatomy (HRCA).

Background: Coronary disease severity is important for therapeutic decision-making and prognostication among patients presenting with NSTE-ACS. However, long-term outcome in patients undergoing percutaneous coronary intervention (PCI) with HRCA is still unknown. Read More

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http://dx.doi.org/10.1155/2020/2139617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229566PMC

Preoperative disturbances of glucose metabolism and mortality after coronary artery bypass grafting.

Open Heart 2020 Jun;7(1)

Medicine, Karolinska Institute, Stockholm, Stockholm County, Sweden

Background: Disturbances of glucose metabolism are important risk factors for coronary artery disease and are associated with an increased mortality risk. The aim was to investigate the association between preoperative disturbances of glucose metabolism and long-term all-cause mortality after coronary artery bypass grafting (CABG).

Methods: Patients undergoing a first isolated CABG in 2005-2013 were included. Read More

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http://dx.doi.org/10.1136/openhrt-2019-001217DOI Listing

Concomitant use of direct oral anticoagulants and aspirin versus direct oral anticoagulants alone in atrial fibrillation and flutter: a retrospective cohort.

BMC Cardiovasc Disord 2020 Jun 1;20(1):263. Epub 2020 Jun 1.

General Internal Medicine Division, Beaumont Health, Royal Oak, MI, USA.

Background: The benefit of combining aspirin and direct oral anticoagulants on the reduction of cardiovascular events in atrial fibrillation or flutter is not well studied. We aimed to assess whether concurrent aspirin and direct oral anticoagulant therapy for atrial fibrillation or flutter will result in less coronary, cerebrovascular and systemic ischemic events compared to direct oral anticoagulant therapy alone.

Methods: Retrospective study of adult patients between 18 and 100 years old who have nonvalvular atrial fibrillation or flutter and were started on a direct oral anticoagulant (apixaban, rivaroxaban, or dabigatran), between January 1, 2010 and September 1, 2015 within the Beaumont Health System. Read More

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http://dx.doi.org/10.1186/s12872-020-01509-xDOI Listing

A case of a gigantic thoracic aortic aneurysm initially mimicking acute coronary syndrome and treated endovascularly.

Korean J Intern Med 2020 Jun 4. Epub 2020 Jun 4.

Department of Cardiology, Chonnam National University Hospital, Gwangju, Korea.

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http://dx.doi.org/10.3904/kjim.2019.440DOI Listing

Matrix Metalloproteinases as Biomarkers of Atherosclerotic Plaque Instability.

Int J Mol Sci 2020 May 31;21(11). Epub 2020 May 31.

Department of Biochemistry and Pharmacogenomics, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland.

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases responsible for tissue remodeling and degradation of extracellular matrix (ECM) proteins. MMPs may modulate various cellular and signaling pathways in atherosclerosis responsible for progression and rupture of atherosclerotic plaques. The effect of MMPs polymorphisms and the expression of MMPs in both the atherosclerotic plaque and plasma was shown. Read More

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http://dx.doi.org/10.3390/ijms21113946DOI Listing

Analytical and Clinical Characterization of a Novel High-Sensitivity Cardiac Troponin Assay in a United States Population.

Clin Biochem 2020 May 30. Epub 2020 May 30.

Department of Emergency Medicine, Baylor College of Medicine, Houston, Texas.

Background: Cardiac troponin (cTn) is the keystone for diagnosis of acute myocardial infarction (AMI). We examined the analytical and clinical diagnostic characteristics of the ACCESS hsTnI assay in a United States (US) population.

Methods: All measurements and studies were conducted using a lithium heparin matrix. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2020.05.014DOI Listing

Aspirin-omitted dual antithrombotics versus triple antithrombotics: a trial sequential analysis.

Eur Heart J Cardiovasc Pharmacother 2020 Jun 2. Epub 2020 Jun 2.

Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.

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http://dx.doi.org/10.1093/ehjcvp/pvaa061DOI Listing

Coexistence and outcome of coronary artery disease in Takotsubo syndrome.

Authors:
L Christian Napp Victoria L Cammann Milosz Jaguszewski Konrad A Szawan Manfred Wischnewsky Sebastiano Gili Maike Knorr Susanne Heiner Rodolfo Citro Eduardo Bossone Fabrizio D'Ascenzo Michael Neuhaus Jennifer Franke Ioana Sorici-Barb Michel Noutsias Christof Burgdorf Wolfgang Koenig Behrouz Kherad Annahita Sarcon Lawrence Rajan Guido Michels Roman Pfister Alessandro Cuneo Claudius Jacobshagen Mahir Karakas Alexander Pott Philippe Meyer Jose D Arroja Adrian Banning Florim Cuculi Richard Kobza Thomas A Fischer Tuija Vasankari K E Juhani Airaksinen Christian Hauck Carla Paolini Claudio Bilato Yoichi Imori Ken Kato Yoshio Kobayashi Grzegorz Opolski Monika Budnik Rafal Dworakowski Philip MacCarthy Christoph Kaiser Stefan Osswald Leonarda Galiuto Wolfgang Dichtl Christina Chan Paul Bridgman Daniel Beug Clément Delmas Olivier Lairez Ibrahim El-Battrawy Ibrahim Akin Ekaterina Gilyarova Alexandra Shilova Mikhail Gilyarov John D Horowitz Karolina Polednikova Petr Tousek Petr Widimský David E Winchester Jan Galuszka Christian Ukena Gregor Poglajen Pedro Carrilho-Ferreira Carlo Di Mario Abhiram Prasad Charanjit S Rihal P Christian Schulze Matteo Bianco Filippo Crea Martin Borggrefe Lars S Maier Fausto J Pinto Ruediger C Braun-Dullaeus Wolfgang Rottbauer Hugo A Katus Gerd Hasenfuß Carsten Tschöpe Burkert M Pieske Holger Thiele Heribert Schunkert Michael Böhm Stephan B Felix Thomas Münzel Jeroen J Bax Johann Bauersachs Eugene Braunwald Thomas F Lüscher Frank Ruschitzka Jelena R Ghadri Christian Templin

Eur Heart J 2020 Jun 2. Epub 2020 Jun 2.

University Heart Center, Department of Cardiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.

Aims: Takotsubo syndrome (TTS) is an acute heart failure syndrome, which shares many features with acute coronary syndrome (ACS). Although TTS was initially described with angiographically normal coronary arteries, smaller studies recently indicated a potential coexistence of coronary artery disease (CAD) in TTS patients. This study aimed to determine the coexistence, features, and prognostic role of CAD in a large cohort of patients with TTS. Read More

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http://dx.doi.org/10.1093/eurheartj/ehaa210DOI Listing
June 2020
15.203 Impact Factor

Impact of environmental pollution and weather changes on the incidence of ST-elevation myocardial infarction.

Eur J Prev Cardiol 2020 Jun 2:2047487320928450. Epub 2020 Jun 2.

Division of Cardiology, Santa Maria Goretti Hospital, Italy.

Background: Environmental pollution and weather changes unfavorably impact on cardiovascular disease. However, limited research has focused on ST-elevation myocardial infarction (STEMI), the most severe yet distinctive form of acute coronary syndrome.

Methods And Results: We appraised the impact of environmental and weather changes on the incidence of STEMI, analysing the bivariate and multivariable association between several environmental and atmospheric parameters and the daily incidence of STEMI in two large Italian urban areas. Read More

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http://dx.doi.org/10.1177/2047487320928450DOI Listing

Ticagrelor alone or conventional dual antiplatelet therapy in patients with stable or acute coronary syndromes.

EuroIntervention 2020 Jun 2. Epub 2020 Jun 2.

Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy.

Aims: To investigate the effect of ticagrelor monotherapy after 1-month dual antiplatelet therapy (DAPT) or conventional DAPT in patients with or without acute coronary syndrome (ACS) in the GLOBAL LEADERS Adjudication Sub-Study (GLASSY).

Methods And Results: Risk estimates were expressed as rate ratios (RR) with 95% confidence intervals (CI). A total of3,840 ACS and 3,745 SIHD (stable ischemic heart disease) patients were included. Read More

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http://dx.doi.org/10.4244/EIJ-D-20-00145DOI Listing

Intracoronary and peripheral blood levels of TNF-like Cytokine 1A (TL1A) in patients with acute coronary syndrome.

Medicine (Baltimore) 2020 May;99(22):e20305

School of Humanities and Management, Fujian University of Traditional Chinese Medicine, Fuzhou, China.

Background: TNF-like cytokine 1A (TL1A) is a subgroup of the tumor necrosis factor superfamily that exerts pleiotropic effects on cell proliferation, inflammation, activation, and differentiation of immune cells. The purpose of the current study is to investigate the clinical significance of TL1A expression in coronary and peripheral blood of patients with acute coronary syndrome (ACS) to determine if TL1A levels can serve as an accurate prognostic indicator.

Methods: A total of 141 patients undergoing coronary angiography were divided into 4 groups: Control (n = 35), Unstable Angina (UA) (n = 35), acute non-ST segment elevation myocardial infarction (NSTEMI) (n = 37), and acute ST segment elevation myocardial infarction (STEMI) (n = 34). Read More

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http://dx.doi.org/10.1097/MD.0000000000020305DOI Listing

Risk Stratification of Sudden Cardiac Death After Acute Myocardial Infarction.

J Innov Card Rhythm Manag 2018 Feb 15;9(2):3035-3049. Epub 2018 Feb 15.

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Despite advances in the diagnosis and treatment of acute coronary syndromes and an overall improvement in outcomes, mortality after myocardial infarction (MI) remains high. Sudden death, which is most frequently due to ventricular tachycardia or ventricular fibrillation, is the cause of death in 25% to 50% of patients with prior MI, and therefore represents an important public health problem. Use of the implantable cardioverter-defibrillator (ICD), which is the primary method of reducing the chance of arrhythmic sudden death after MI, is costly to the medical system and is associated with procedural and long-term risks. Read More

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http://dx.doi.org/10.19102/icrm.2018.090201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252689PMC
February 2018

Impact of hospital-acquired complications in long-term clinical outcomes after subarachnoid hemorrhage.

Clin Neurol Neurosurg 2020 May 20;194:105945. Epub 2020 May 20.

Department of Neurological Surgery, Montefiore Medical Center, Bronx, NY USA.

Objective: Patients with subarachnoid hemorrhage (SAH) usually have prolonged hospitalizations due to the need to closely monitor their neurological status. Therefore, these patients have higher risk of experiencing hospital-acquired complications (HACs), which can complicate their clinical course and recovery. However, there is no evidence on the impact of HACs of long-term clinical outcomes. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.105945DOI Listing

Clinical Impact of Valvular Heart Disease in Elderly Patients Admitted for Acute Coronary Syndrome: Insights From the Elderly-ACS 2 Study.

Can J Cardiol 2019 Nov 21. Epub 2019 Nov 21.

Department of Cardiology, Multimedica IRCSS, Milan, Italy.

Background: Elderly patients are under-represented in clinical trials and registries, and a gap of evidence exists for clinical decision making in the setting of acute coronary syndromes (ACS). We aimed to assess the prevalence and independent prognostic impact of valvular heart disease (VHD) diagnosed during the index hospitalization on clinical outcomes among elderly patients with ACS. Included VHDs were moderate-to-severe mitral regurgitation (MR), moderate-to-severe aortic stenosis (AS), or both combined. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.11.014DOI Listing
November 2019

Isolated Pulmonary Fusariosis Caused by Neocosmospora pseudensiformis in a Liver Transplant Recipient: A Case Report and Review of the Literature.

Transpl Infect Dis 2020 Jun 1:e13344. Epub 2020 Jun 1.

Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Neocosmospora pseudensiformis (formerly Fusarium pseudensiforme) is a hyaline mold in the Fusarium solani species complex that has been changed to the genus Neocosmospora. Invasive fusariosis is a rare fungal infection in solid organ transplantation. The most commonly reported manifestation of invasive fusariosis in this setting is localized cutaneous fusariosis. Read More

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http://dx.doi.org/10.1111/tid.13344DOI Listing

Acute Anterior STEMI in Multivessel Spontaneous Coronary Dissections.

J Invasive Cardiol 2020 Jun;32(6):E176

Centro Cardiologico Monzino, IRCCS, Via Carlo Parea 4-20138 Milan, Italy.

Spontaneous coronary artery dissection (SCAD) has a prevalence between 0.2%-4% of all acute coronary syndromes. Multivessel SCAD is unusual. Read More

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Adapting STEMI care for the COVID-19 pandemic: The case for low-risk STEMI triage and early discharge.

Catheter Cardiovasc Interv 2020 Jun 1. Epub 2020 Jun 1.

The Carl and Edyth Lindner Center for Research and Development, The Christ Hospital, Cincinnati, Ohio, USA.

The coronavirus pandemic has resulted in the need for rapid assessment of resource utilization within our hospital systems. Specifically, the overwhelming need for intensive care unit (ICU) beds within epicenters of the pandemic has created a need for consideration as to how acute coronary syndrome cases, and specifically ST-elevation myocardial infarction (STEMI) patients, are managed postprocedure. While most patients in the United States continue to be managed in coronary care units after primary percutaneous coronary intervention, there is a robust literature regarding the ability to triage STEMI patients safely and efficiently with low-risk features to non-ICU beds. Read More

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http://dx.doi.org/10.1002/ccd.28993DOI Listing

Patient care protocols and personal safety measures for health care professionals in cardiac catheterization rooms during the COVID-19 outbreak in the National Institute of Cardiology.

Catheter Cardiovasc Interv 2020 Jun 1. Epub 2020 Jun 1.

Department of Interventional Cardiology, Ignacio Chavez National Institute of Cardiology, Mexico City, Mexico.

The COVID-19 was first described in late 2019 that quickly became a pandemic affecting every health system as we know it. The high transmissibility among humans represents a well-known high burden of morbidity and mortality not only for cardiovascular patients but also for a higher risk between health care professionals that must deliver high-quality care to them in any scenario, and cardiac catheterization rooms are no exception. This creates a new dilemma, minimize exposure to patients and health care professionals to COVID-19 while maintaining high quality in cardiovascular therapeutics. Read More

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http://dx.doi.org/10.1002/ccd.28979DOI Listing

Percutaneous coronary intervention of unprotected left main and bifurcation in octogenarians: Subanalysis from RAIN (veRy thin stents for patients with left mAIn or bifurcatioN in real life).

Catheter Cardiovasc Interv 2020 Jun 1. Epub 2020 Jun 1.

Division of Cardiology, Department of Internal Medicine, Città della Salute e della Scienza, Torino, Italy.

Objective: Outcomes of complex percutaneous coronary interventions (PCIs) in older patients are still debated. The aim of the study was to evaluate clinical outcomes of Octogenarian patients treated with ultrathinstents on left main or on coronary bifurcations, compared with younger patients.

Methods: All consecutive patients presenting a critical lesion of an unprotected left main (ULM) or a bifurcation and treated with very thin stents were included in the RAIN (veRy thin stents for patients with left mAIn or bifurcatioN in real life) registry and divided into octogenarians group (OG, 551 patients) and nonoctogenarians (NOGs, 2,453 patients). Read More

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http://dx.doi.org/10.1002/ccd.29048DOI Listing

Clinical importance of high- sensitivity troponin T in patients without coronary artery disease.

North Clin Istanb 2020 9;7(3):305-310. Epub 2020 Apr 9.

Department of Cardiology, Adiyaman Training and Research Hospital, Adiyaman, Turkey.

Cardiac troponin is the preferred biomarker for the diagnosis of the acute coronary syndrome (ACS), but many other diseases can be identified with elevated troponin levels in the absence of ACS. The recent development of a high-sensitive cardiac troponin T (hs-cTnT) assay permits the detection of very low levels of cTnT. The use of hs-cTnT assay has emerged as a tool for identifying high-risk individuals for primary preventive treatment and can detect subclinical injury in asymptomatic patients. Read More

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http://dx.doi.org/10.14744/nci.2019.71135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251271PMC

Prasugrel Versus Ticagrelor in Patients With CYP2C19 Loss-of-Function Genotypes: Results of a Randomized Pharmacodynamic Study in a Feasibility Investigation of Rapid Genetic Testing.

JACC Basic Transl Sci 2020 May 25;5(5):419-428. Epub 2020 Mar 25.

University of Florida College of Medicine-Jacksonville, Jacksonville, Florida.

The feasibility of rapid genetic testing in patients undergoing percutaneous coronary intervention (PCI) and the comparison of the pharmacodynamic effects of prasugrel versus ticagrelor among carriers of cytochrome P450 2C19 loss-of-function alleles treated with PCI has been poorly explored. Rapid genetic testing using the Spartan assay was shown to be feasible and provides results in a timely fashion in a real-world setting of patients undergoing coronary angiography (n = 781). Among patients (n = 223, 28. Read More

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http://dx.doi.org/10.1016/j.jacbts.2020.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251226PMC

The Use of Beta Blockers in Takotsubo Syndrome as Compared to Acute Coronary Syndrome.

Front Pharmacol 2020 14;11:681. Epub 2020 May 14.

First Department of Medicine, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany.

Background: Takotsubo syndrome (TTS) and acute coronary syndrome (ACS) patients have a similar mortality rate. In this study, we sought to determine the short- and long-term outcome of TTS patients as compared to ACS patients both treated with beta-blockers.

Objectives: In the present study we described the data of 5 years of follow up of 103 TTS and 422 ACS patients both treated with beta-blockers. Read More

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http://dx.doi.org/10.3389/fphar.2020.00681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240099PMC

Identification of Novel Molecular Network Expression in Acute Myocardial Infarction.

Curr Genomics 2019 Aug;20(5):340-348

Medicinal Biochemistry and Molecular Biology Department, Ain Shams University, Faculty of Medicine, Cairo, Egypt.

Background: In the current study, we aimed to analyze the hypothesis that human myocardial-specific extracellular RNAs expression could be used for acute myocardial injury(AMI) diagnosis.

Methodology: We used bioinformatics' analysis to identify RNAs linked to ubiquitin system and specific to AMI, named, (lncRNA-RP11-175K6.1), (LOC101927740), microRNA-106b-5p (miR-106b-5p) and Anaphase, promoting complex 11 (). Read More

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http://dx.doi.org/10.2174/1389202920666190820142043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235391PMC

Double Antithrombotic versus Triple Antithrombotic Therapy in Patients with Atrial Fibrillation and Acute Coronary Syndrome.

Authors:
Surya Dharma

Int J Angiol 2020 Jun 21;29(2):81-87. Epub 2020 Mar 21.

Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.

In atrial fibrillation (AF), oral anticoagulant (OAC) therapy with either vitamin K antagonist or non-vitamin K antagonist is used to prevent thromboembolic complications. In patients who presented with acute coronary syndrome (ACS) and were treated by percutaneous coronary intervention (PCI), dual antiplatelet therapy (DAPT) with aspirin and a P2Y inhibitor reduces major adverse cardiac events (MACEs) and stent thrombosis. Consequently, in patients with AF who presented with ACS and were treated by PCI, the combination of OAC and DAPT, the so-called triple antithrombotic therapy (TAT) is needed to improve the outcome of the patients. Read More

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http://dx.doi.org/10.1055/s-0040-1702208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250634PMC