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    1 OF 496

    Effect of high-dose rosuvastatin loading before percutaneous coronary intervention in Chinese patients with acute coronary syndrome: A systematic review and meta-analysis.
    PLoS One 2017 23;12(2):e0171682. Epub 2017 Feb 23.
    Department of Cardiology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
    Background: Acute coronary syndrome (ACS) is an important disease threatening human life and health. Many studies have shown that the loading dose of atorvastatin can significantly improve the prognosis of patients with ACS, and reduce the mortality. However, this conclusion is not consistent. Read More

    Basigin rs8259 Polymorphism Confers Decreased Risk of Chronic Heart Failure in a Chinese Population.
    Int J Environ Res Public Health 2017 Feb 21;14(2). Epub 2017 Feb 21.
    Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.
    Left ventricular remodeling is an essential risk factor contributing to the pathogenesis of chronic heart failure (CHF). Basigin (BSG) promotes cardiovascular inflammation and myocardial remodeling processes by induction of extracellular matrix metalloproteinases and inflammatory cytokines. BSG rs8259 polymorphism was associated with BSG expression and risk of acute coronary syndrome. Read More

    Gender differences in clinical presentation and 1-year outcomes in atrial fibrillation.
    Heart 2017 Feb 22. Epub 2017 Feb 22.
    Institute of Cardiovascular Sciences, University of Birmingham and SWBH and UHB NHS Trust, Birmingham, UK.
    Objectives: Our objective was to examine gender differences in clinical presentation, management and prognosis of atrial fibrillation (AF) in a contemporary cohort.

    Methods: In 6412 patients, 39.7% women, of the PREvention oF thromboembolic events - European Registry in Atrial Fibrillation, we examined gender differences in symptoms, risk factors, therapies and 1-year incidence of adverse outcomes. Read More

    Pre-hospital acute coronary syndrome care in Kerala, India: A qualitative analysis.
    Indian Heart J 2017 Jan - Feb;69(1):93-100. Epub 2016 Jul 19.
    Departments of Preventive Medicine and Medicine-Cardiology, Northwestern University Feinberg School of Medicine, Chicago, USA.
    Objective: Ischemic heart disease is the leading cause of death in India. Many of these deaths are due to acute coronary syndromes (ACS), which require prompt symptom recognition, care-seeking behavior, and transport to a treatment facility in the critical pre-hospital period. In India, little is known about pre-hospital management of individuals with ACS. Read More

    The effect of MElatonin on Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome (MEDACIS): study protocol for a randomized controlled trial.
    Trials 2017 Feb 23;18(1):81. Epub 2017 Feb 23.
    Department of Surgery, Zealand University Hospital, University of Copenhagen, Lykkebaekvej 1, 4600, Koege, Denmark.
    Background: Depression following acute coronary syndrome (ACS) constitutes a serious and debilitating problem. Approximately one in five patients will develop significant depression following ACS and less severe depressive symptoms are even more frequent. Furthermore, anxiety symptoms and sleep-wake disturbances are frequent. Read More

    Acute myocardial infarction and antiphospholipid antibody syndrome: a systematic review.
    Coron Artery Dis 2017 Feb 20. Epub 2017 Feb 20.
    aInternal Medicine Resident, Reading Health System, Reading bDepartment of Cardiology cDepartment of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
    Background: Antiphospholipid antibody syndrome (APS) is a disorder associated with both arterial and venous thromboembolic disease, including acute myocardial infarction (AMI). Given that management with anticoagulants is critical and differs from usual AMI care, identification of key discriminators of patients with AMI with APS is important.

    Methods: We performed an English-language systematic review of the literature of cases and case series of patients with AMI and APS from inception until 20 March 2016, collecting demographics, investigations, and outcomes. Read More

    The EXERRT trial: "EXErcise to Regadenoson in Recovery Trial": A phase 3b, open-label, parallel group, randomized, multicenter study to assess regadenoson administration following an inadequate exercise stress test as compared to regadenoson without exercise for myocardial perfusion imaging using a SPECT protocol.
    J Nucl Cardiol 2017 Feb 21. Epub 2017 Feb 21.
    Saint Luke's Mid America Heart Institute, Kansas City, MO, USA.
    Background: This study assessed the non-inferiority and safety of regadenoson administration during recovery from inadequate exercise compared with administration without exercise.

    Methods: Patients unable to achieve adequate exercise stress were randomized to regadenoson 0.4 mg either during recovery (Ex-Reg) or 1 hour after inadequate exercise (Regadenoson) (MPI1). Read More

    Upregulation of TH/IL-17 Pathway-Related Genes in Human Coronary Endothelial Cells Stimulated with Serum of Patients with Acute Coronary Syndromes.
    Front Cardiovasc Med 2017 7;4. Epub 2017 Feb 7.
    Department of Experimental Medicine, Section of Pharmacology, University of Campania "Luigi Vanvitelli" , Naples , Italy.
    Background: Inflammation plays an essential role in the development and complications of atherosclerosis plaques, including acute coronary syndromes (ACS). Indeed, previous reports have shown that within the coronary circulation of ACS patients, several soluble mediators are released. Moreover, it has been demonstrated that endothelial dysfunction might play an important role in atherosclerosis as well as ACS pathophysiology. Read More

    Genotyping-guided approach versus the conventional approach in selection of oral P2Y12 receptor blockers in Chinese patients suffering from acute coronary syndrome.
    J Int Med Res 2017 Feb 22;45(1):134-146. Epub 2016 Dec 22.
    1 Division of Cardiology, Queen Mary Hospital, The University of Hong Kong.
    Objective The CYP2C19 loss-of-function (LoF) allele is present in half of the East Asian population and is associated with high on-treatment platelet reactivity (HTPR). This study aimed to investigate whether a rapid genotyping-guided approach is feasible and efficacious for selecting P2Y12 receptor blockers in Chinese patients suffering from acute coronary syndrome (ACS). Methods This was a single-centre, prospective, randomized, open-label study. Read More

    Significance of new Q waves and their location in postoperative ECGs after elective on-pump cardiac surgery: An observational cohort study.
    Eur J Anaesthesiol 2017 Feb 17. Epub 2017 Feb 17.
    From the Department for Anesthesia, Surgical Intensive Care, Prehospital Emergency Medicine and Pain Therapy (EM, DB, JF, EES, GALLB); Division of Cardiac Surgery, Basel University Hospital (MG); and Basel University Medical School, Basel, Switzerland (MDS, MF).
    Background: The clinical significance of new pathological Q waves after on-pump cardiac surgery is uncertain.

    Objectives: To determine whether or not either the occurrence per se or the location of new pathological Q waves after on-pump cardiac surgery is associated with 12-month, all-cause mortality and/or major adverse cardiac events (MACEs).

    Design: Observational cohort study. Read More

    Arterial structure and function in subjects with acute coronary syndrome after one-year of treatment.
    Pol Arch Med Wewn 2017 Feb 15. Epub 2017 Feb 15.
    INTRODUCTION    It is controversial whether the modification of arterial stiffness and intima-media thickness (IMT) is plausible in patients with clinically significant atherosclerosis.  OBJECTIVES    We evaluated the effects of the one-year pharmacological therapy on the arterial stiffness and IMT in survivors of non-ST elevation myocardial infarction (NSTEMI) who were treated according to the clinical guidelines.  PATIENTS AND METHODS    For this study 298 NSTEMI patients (median age 64 years; 85 females) were enrolled. Read More

    [Correlation between cytochrome 3A4+894C>T P450 gene polymorphism and outcomes of coronary intervention in patients with acute coronary syndrome].
    Nan Fang Yi Ke Da Xue Xue Bao 2016 Feb;37(2):261-265
    Department of Cardiology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China. E-mail:
    Objective: To investigate the relationship between plasma cytochrome P450 3A4 (CYP3A4) 894C>T gene polymorphism and the risk of recurrence of adverse cardiac events after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS).

    Methods: A total of 275 patients with ACS received standard dual antiplatelet therapy and PCI. Platelet aggregation rate (PAR) was detected in each patient before and 7 days after administration of the anti-platelet drugs. Read More

    High incidence of abnormal glucose metabolism in acute coronary syndrome patients at a moderate altitude: A sub-Himalayan study.
    Indian J Endocrinol Metab 2017 Jan-Feb;21(1):142-147
    Department of Medicine, IGMC, Shimla, Himachal Pradesh, India.
    Background: Abnormal glucose metabolic status at admission is an important marker of future cardiovascular events and long-term mortality after acute coronary syndrome (ACS), whether or not they are known diabetics.

    Objective: The aims were to study the prevalence of abnormal glucose metabolism in ACS patients and to compare the different methods of diagnosing diabetes in ACS patients.

    Methods: We did a prospective study. Read More

    Association between delay to coronary reperfusion and outcome in patients with acute coronary syndrome undergoing extracorporeal cardiopulmonary resuscitation.
    Resuscitation 2017 Feb 16. Epub 2017 Feb 16.
    Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
    Aim: The prognostic effect of early coronary reperfusion therapy with extracorporeal cardiopulmonary resuscitation (ECPR) in patients with cardiac arrest due to acute coronary syndrome (ACS) has yet to be clarified. We investigated the relationship between time interval from collapse to start of ECPR (CtoE) and coronary reperfusion (CtoR) time and neurological outcome in patients with cardiac arrest due to ACS.

    Methods: A cohort of 119 consecutive patients (63±12 years old) with ACS who underwent ECPR and percutaneous coronary intervention(PCI) at our hospital was registered from January 2005 to June 2016. Read More

    Impact of Diabetes Mellitus on Long-Term Mortality in Patients Presenting for Coronary Angiography.
    Am J Cardiol 2017 Jan 25. Epub 2017 Jan 25.
    Department of Cardiovascular Medicine, Lady Davis Carmel Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
    To understand the current impact of diabetes mellitus (DM) on long-term outcomes among patients referred for coronary angiography, we studied 14,337 consecutive patients (5,279 diabetic patients [37%]) referred to coronary angiography for assessment or treatment of coronary artery disease. We investigated long-term all-cause mortality and its interaction with hypoglycemic therapy and presenting coronary status. At baseline, patients with DM had more hypertension, hyperlipidemia, and renal failure; more were women, overweight, and more had previous coronary interventions. Read More

    Association between plaque characteristics and the amount of debris captured by a filter-type distal protection device in patients with acute coronary syndrome.
    Atherosclerosis 2017 Feb 8;258:72-78. Epub 2017 Feb 8.
    Department of Cardiology, Nagoya Graduate School of Medicine, Nagoya, Japan.
    Background And Aims: Disruption of atherosclerotic plaque and distal embolism often cause peri-procedural myocardial injury during percutaneous coronary intervention (PCI). In the present study, we evaluate the association between the characteristics of the target lesion and the amount of debris captured by the filter-type distal protection device.

    Methods: We enrolled 120 consecutive patients with acute coronary syndrome, who underwent coronary stent implantation with a filter-type distal protection device after integrated backscatter intravascular ultrasound (IB-IVUS) analysis. Read More

    Mitochondria-targeted Esculetin Inhibits PAI-1 Levels by Modulating STAT3 Activation and miR-19b via SIRT3: Role in Acute Coronary Artery Syndrome.
    J Cell Physiol 2017 Feb 18. Epub 2017 Feb 18.
    Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad, 500007, India.
    In this study, we explored the microRNAs responsible for the regulation of PAI-1 during LPS-stimulated inflammation in human aortic endothelial cells, subsequently studied the effect of a newly synthesized mitochondria-targeted esculetin (Mito-Esc) that was shown for its anti-atherosclerotic potential in modulating PAI-1 levels and its targeted miRs during angiotensin-II-induced atherosclerosis in ApoE(-/-) mice. LPS-stimulated PAI-1 was accompanied with an upregulation of miR-19b and down-regulation of miR-30c. These effects of LPS on PAI-1 were reversed in the presence of both parent esculetin and Mito-Esc. Read More

    Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients.
    Front Med 2017 Feb 17. Epub 2017 Feb 17.
    Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
    Low adherence to secondary prevention medications (ATM) of patients after acute coronary syndrome (ACS) is associated with poor clinical outcomes. However, literature provides limited data on assessment of ATM and risks associated with poor in Chinese patients with ACS. In the current work, ATM was assessed in consecutively recruited patients with ACS in Tongji Hospital from November 5, 2013 to December 31, 2014. Read More

    Prasugrel for Japanese patients with acute coronary syndrome in short-term clinical practice (PRASFIT-Practice I): a postmarketing observational study.
    Cardiovasc Interv Ther 2017 Feb 17. Epub 2017 Feb 17.
    Pharmacovigilance Department, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
    Data on prasugrel use in Japanese patients are limited to phase II/III clinical trials. This early postmarketing observational study evaluated the safety and efficacy of short-term prasugrel use in patients with acute coronary syndrome (ACS) in real-world clinical settings in Japan. From May 2014 to January 2015, we enrolled consecutive patients with ACS requiring percutaneous coronary intervention in each institution. Read More

    White cell count in the normal range and short-term and long-term mortality: international comparisons of electronic health record cohorts in England and New Zealand.
    BMJ Open 2017 Feb 17;7(2):e013100. Epub 2017 Feb 17.
    Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, London, UK.
    Objectives: Electronic health records offer the opportunity to discover new clinical implications for established blood tests, but international comparisons have been lacking. We tested the association of total white cell count (WBC) with all-cause mortality in England and New Zealand.

    Setting: Primary care practices in England (ClinicAl research using LInked Bespoke studies and Electronic health Records (CALIBER)) and New Zealand (PREDICT). Read More

    Point-of-care ultrasonography for evaluation of acute dyspnea in the emergency department.
    Chest 2017 Feb 14. Epub 2017 Feb 14.
    Emergency Department, Careggi University Hospital, Florence, Italy.
    Background: Acute dyspnea is a common symptom in the emergency department (ED). Standard approach to dyspnea often relies on radiologic and laboratoristic results, causing excessive delay before adequate therapy is started; an integrated point-of-care ultrasonography (PoCUS) approach can shorten the time needed to formulate a diagnosis maintaining an acceptable safety profile.

    Methods: Consecutive adult patients presenting with dyspnea and admitted after ED evaluation were prospectively enrolled. Read More

    Race and place differences in patients hospitalized with an acute coronary syndrome: Is there double jeopardy? Findings from TRACE-CORE.
    Prev Med Rep 2017 Jun 24;6:1-8. Epub 2017 Jan 24.
    Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, United States.
    The objectives of this longitudinal study were to examine differences between whites and blacks, and across two geographical regions, in the socio-demographic, clinical, and psychosocial characteristics, hospital treatment practices, and post-discharge mortality for hospital survivors of an acute coronary syndrome (ACS). In this prospective cohort study, we performed in-person interviews and medical record abstractions for patients discharged from the hospital after an ACS at participating sites in Central Massachusetts and Central Georgia during 2011-2013. Among the 1143 whites in Central Massachusetts, 514 whites in Central Georgia, and 277 blacks in Central Georgia, we observed a gradient of socioeconomic position with whites in Central Massachusetts being the most privileged, followed by whites and then blacks from Central Georgia; similar gradients pertained to psychosocial vulnerability (e. Read More

    Suboptimal achievement of low-density lipoprotein cholesterol targets in French patients with coronary heart disease. Contemporary data from the DYSIS II ACS/CHD study.
    Arch Cardiovasc Dis 2017 Feb 13. Epub 2017 Feb 13.
    Herzzentrum Ludwigshafen, Medizinische Klinik B, Kardiologie, Ludwigshafen, Germany.
    Background: European guidelines recommend a low-density lipoprotein cholesterol (LDL-C) target of<1.8mmol/L (70mg/dL), and/or a≥50% reduction when the target level cannot be reached, for patients at very high cardiovascular risk, and high-potency lipid-lowering therapy (LLT) in patients with an acute coronary syndrome (ACS).

    Aim: To document the prevalence of lipid abnormalities and the achievement of lipid targets among patients surviving an ACS and in patients with stable coronary heart disease (CHD), using data from the DYSIS II study. Read More

    Anomalous Single Coronary Artery Presenting with Acute Myocardial Infarction.
    J Clin Diagn Res 2016 Dec 1;10(12):OD01-OD02. Epub 2016 Dec 1.
    Assistant Professor, Department of CVJ, Kasturba Medical College, Manipal University , Manipal, Karnataka, India .
    The anomalous origin of the entire coronary system from the right coronary sinus is a very rare anomaly. Here a patient with this rare anomaly, who developed acute coronary syndrome, requiring revascularization, is presented and treated successfully. His coronary angiographic findings are also discussed. Read More

    Assessment of Serum VASPIN Levels among Type 2 Diabetes Mellitus Patients with or without Acute Coronary Syndrome.
    J Clin Diagn Res 2016 Dec 1;10(12):BC07-BC10. Epub 2016 Dec 1.
    Associate Professor, Department of Medicine, Kanachur Institute of Medical Sciences & Research Center , Mangalore, Andhra Pradesh, India .
    Introduction: Type 2 Diabetes Mellitus (DM) is on the verge of becoming a pandemic in India. Type 2 DM patient have two to four times increased risk of carotid artery disease. Adipokines have been regarded recently as direct link between diabetes and atherosclerosis. Read More

    Isolated cardiac troponin rise does not modify the prognosis in elderly patients with hip fracture.
    Medicine (Baltimore) 2017 Feb;96(7):e6169
    aSorbonne Universités UPMC Univ Paris 06, DHU FAST bUMRS INSERM 1166, IHU ICAN cUMRS INSERM 1158 dDepartment of Geriatry eDepartment of Anesthesiology and Critical Care fDepartment of Emergency Medicine and Surgery gDepartment of Orthopedic Surgery and Trauma Groupe Hospitalier (GH) Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France hDepartments of Anesthesia & Clinical Epidemiology and Biostatistics, Michael DeGroote School of Medicine, Population Health Research Institute, Perioperative Medicine and Surgical Research Unit, Faculty of Health Sciences, McMaster University, Hamilton, Canada iDepartment of Rehabilitation, GH Charles Foix, APHP, Ivry sur Seine jCentre National de la Recherche Scientifique (CNRS), Paris, France.
    Perioperative myocardial infarction remains a life-threatening complication in noncardiac surgery and even an isolated troponin rise (ITR) is associated with significant mortality. Our aim was to assess the prognostic value of ITR in elderly patients with hip fracture.In this cohort study, all patients admitted between 2009 and 2013 in our dedicated geriatric postoperative unit after hip fracture surgery with a cardiac troponin I determination were included and divided into Control, ITR, and acute coronary syndrome (ACS) groups. Read More

    Arginine methylation dysfunction increased risk of acute coronary syndrome in coronary artery disease population: A case-control study.
    Medicine (Baltimore) 2017 Feb;96(7):e6074
    aDepartment of Internal Medicine bDepartment of Cardiology cClinical Pharmacology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
    The plasma levels of asymmetric dimethylarginine (ADMA) had been proved to be an independent cardiovascular risk factor. Few studies involved the entire arginine methylation dysfunction. This study was designed to investigate whether arginine methylation dysfunction is associated with acute coronary syndrome risk in coronary artery disease population. Read More

    Association of serum gamma-glutamyltransferase and premature coronary artery disease.
    Neth Heart J 2017 Feb 15. Epub 2017 Feb 15.
    Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Serum gamma-glutamyltransferase (GGT) has been introduced as a predictive factor for cardiovascular disease. In this study, we investigated the association of serum GGT and premature coronary artery disease (CAD) in candidates for coronary angiography.

    Methods: In this cross-sectional study, we enrolled male subjects aged ≤45 years and female subjects ≤55 years who were candidates for elective coronary angiography due to typical chest pain or a positive non-invasive test. Read More

    Comparison of Platelet Reactivity in Black Versus White Patients With Acute Coronary Syndromes After Treatment With Ticagrelor.
    Am J Cardiol 2017 Jan 25. Epub 2017 Jan 25.
    Division of Cardiology, Medstar Heart and Vascular Institute, Washington, DC. Electronic address:
    Ticagrelor, a potent platelet inhibitor, has primarily been studied in white patients. Platelet reactivity among black patients with acute coronary syndrome (ACS) on ticagrelor, however, is unknown. Our objective was to compare platelet reactivity in black versus white patients with ACS treated with ticagrelor. Read More

    Recurrent contrast-induced encephalopathy following coronary angiography.
    Intern Med J 2017 Feb;47(2):221-224
    Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia.
    Contrast-induced encephalopathy (CIE) is an acute and reversible neurological disturbance associated with the intra-arterial administration of iodinated contrast medium during cardiac catheterisation. It may manifest with encephalopathy, motor and sensory disturbances; vision disturbances, including cortical blindness, ophthalmoplegia, aphasia; and seizures. Disruption of the blood-brain barrier and direct neuronal toxicity are believed to be implicated in the pathophysiology of the syndrome. Read More

    Impact of comorbidities by age on symptom presentation for suspected acute coronary syndromes in the emergency department.
    Eur J Cardiovasc Nurs 2017 Feb 1:1474515117693891. Epub 2017 Feb 1.
    1 Department of Biobehavioral Sciences, College of Nursing, University of Illinois at Chicago, Chicago, IL, USA.
    Background: It is estimated half of acute coronary syndrome (ACS) patients have one or more associated comorbid conditions.

    Aims: Aims were to: 1) examine the prevalence of comorbid conditions in patients presenting to the emergency department with symptoms suggestive of ACS; 2) determine if comorbid conditions influence ACS symptoms; and 3) determine if comorbid conditions predict the likelihood of receiving an ACS diagnosis.

    Methods: A total of 1064 patients admitted to five emergency departments were enrolled in this prospective study. Read More

    Acute "Pseudoischemic" ECG Abnormalities after Right Pneumonectomy.
    Case Rep Surg 2017 18;2017:7872535. Epub 2017 Jan 18.
    Clinic for Pulmonary Diseases, Clinical Center of Serbia, Belgrade, Serbia.
    New onset of electrocardiographic (ECG) abnormalities can occur after lung surgery due to the changes in the position of structures and organs in the chest cavity. The most common heart rhythm disorder is atrial fibrillation. So-called "pseudoischemic" ECG changes that mimic classic ECG signs of acute myocardial ischemia are also often noticed. Read More

    ST-Segment Elevation Myocardial Infarction: Door to Balloon Time Improvement Project.
    Cardiol Res 2016 Aug 5;7(4):152-156. Epub 2016 Sep 5.
    King Faisal Cardiac Center, King Abdulaziz Medical City, Jeddah, Saudi Arabia.
    Background: The purpose of this quality improvement project was to evaluate prospectively the causes of delay for patients with acute ST-segment elevation myocardial infarction (STEMI) requiring primary percutaneous coronary intervention (PCI) upon arrival at the emergency department (ED) and implement recommendations to reduce delays and analyze the impact of recommendations to reduce the door-to-balloon (D2B) time in a newly established cardiac center (King Faisal Cardiac Center (KFCC)). Primary PCI has developed as an effective treatment strategy for acute STEMI, the survival rate and patient outcome are however dependent on the time to treatment. The international benchmark for all programs dealing with acute coronary syndrome patients suffering from STEMI has been established as 90 minutes or less from the time the patient arrives at the hospital to the opening of the affected vessel in the cardiac catheterization laboratory "door-to-balloon time" or D2B. Read More

    Association of Coronary Artery Calcium in Adults Aged 32 to 46 Years With Incident Coronary Heart Disease and Death.
    JAMA Cardiol 2017 Feb 8. Epub 2017 Feb 8.
    Department of Epidemiology, Colorado School of Public Health, Aurora.
    Importance: Coronary artery calcium (CAC) is associated with coronary heart disease (CHD) and cardiovascular disease (CVD); however, prognostic data on CAC are limited in younger adults.

    Objective: To determine if CAC in adults aged 32 to 46 years is associated with incident clinical CHD, CVD, and all-cause mortality during 12.5 years of follow-up. Read More

    Low Adverse Event Rates But High Emergency Department Utilization in Chest Pain Patients Treated in an Emergency Department Observation Unit.
    Crit Pathw Cardiol 2017 Mar;16(1):15-21
    From the *Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI; and †Department of Emergency Medicine, Injury Prevention Center, Warren Alpert Medical School of Brown University, Providence, RI.
    Objectives: Nearly 40% of all previously admitted chest pain patients re-present to the emergency department (ED) within 1 year regardless of stress testing, and nearly 5% of patients return with a major adverse cardiac event (MACE). The primary objective of this study was to determine the prevalence of return visits to the ED among patients previously admitted to an ED chest pain observation unit (CPU). We also identified the patient characteristics and health risk factors associated with these return ED visits. Read More

    Systematic underutilisation of secondary preventive drugs in patients with acute coronary syndrome and reduced renal function.
    Eur J Prev Cardiol 2017 Jan 1:2047487317693950. Epub 2017 Jan 1.
    1 Division of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd University Hospital, Karolinska Institutet, Stockholm, Sweden.
    Aims The high risk of recurrent events in patients with reduced renal function following an acute coronary syndrome (ACS) may in part be due to suboptimal secondary prevention. We aimed to describe the association between renal dysfunction and the prescription, initiation and persistent use of secondary prevention during the first year after a first ACS. Methods We identified all patients admitted to any Swedish coronary care unit for a first ACS between 2005 and 2010 ( n = 77,432). Read More

    Baseline Adiponectin Concentration and Clinical Outcomes among Patients with Diabetes and Recent Acute Coronary Syndrome in the EXAMINE Trial.
    Diabetes Obes Metab 2017 Feb 14. Epub 2017 Feb 14.
    TIMI Study Group, Universite de Lorraine and CHRU, Nancy, France.
    Introduction: Adiponectin is a pleiotropic adipocytokine with a strong inverse (protective) association with obesity, diabetes, and cardiovascular outcomes in stable patients. However, this relationship may be reversed in the setting of acute coronary syndrome (ACS). Given this possible complex relationship, we investigated adiponectin and cardiovascular (CV) outcomes in patients with diabetes and recent ACS. Read More

    Aspirin Desensitization in Patients With Coronary Artery Disease: Results of the Multicenter ADAPTED Registry (Aspirin Desensitization in Patients With Coronary Artery Disease).
    Circ Cardiovasc Interv 2017 Feb;10(2)
    From the Dipartimento Cardiovascolare, ASST Papa Giovanni XXIII, Bergamo, Italy (R.R., A.I., G.M., M.S.); Division of Cardiology, A.O.U San Luigi Gonzaga, Orbassano, Torino, Italy (R.P., M.B.); IRCCS Fondazione Policlinico S. Matteo, Pavia, Italy (S.L.); Divisione di Cardiologia, Ospedale Carlo Poma, Mantova, Italy (C.L.); Cardiologia 1 Emodinamica, Dipartimento Cardiovascolare, ASST Niguarda Grande Ospedale Metropolitano, Milano, Italy (I.B., P.C.); U.O. Emodinamica, Ospedale Sandro Pertini, Roma, Italy (S.R.); Università degli Studi di Pavia, Italy (C.D.); Unità operativa di Cardiologia, Humanitas Mater Domini, Castellanza (Varese), Italy (A.A.); Cardio-Thoracic-Vascular Department, Ferrarotto Hospital, University of Catania, Italy (D.C.); and Division of Cardiology, University of Florida College of Medicine, Jacksonville (D.J.A.).
    Background: There are limited data on aspirin (ASA) desensitization for patients with coronary artery disease. The aim of the present study was to assess the safety and efficacy of a standard rapid desensitization protocol in patients with ASA sensitivity undergoing coronary angiography.

    Methods And Results: This is a prospective, multicenter, observational study including 7 Italian centers including patients with a history of ASA sensitivity undergoing coronary angiography with intent to undergo percutaneous coronary intervention. Read More

    Is Telemetry Monitoring Useful in Patients Admitted With Suspected Acute Coronary Syndrome?
    Am J Med Qual 2017 Feb 1:1062860617690803. Epub 2017 Feb 1.
    2 Medstar Franklin Square Medical Center, Baltimore, MD.
    Patients with a chief complaint of chest pain are frequently monitored by telemetry for evaluation of acute coronary syndrome (ACS). However, there is insufficient evidence to support this practice in younger patients without coronary artery disease (CAD). The objective is to assess outcomes of patients younger than 50 years of age and monitored by telemetry. Read More

    Anticoagulant therapy for non-ST-segment elevation acute coronary syndrome in China: A multi-center observational study.
    J Transl Int Med 2016 Apr 14;4(1):25-28. Epub 2016 Apr 14.
    Heart Center, Peking University People's Hospital, Peking 100044, China.
    Objective: To assess the anticoagulant therapy for non-ST-segment elevation acute coronary syndrome (NSTE-ACS) in China and to offer the rationale for establishing reasonable strategies to improve the prognosis of NSTE-ACS.

    Methods: A total of 1,502 patients with NSTE-ACS were recruited from 28 third-grade hospitals distributed in 14 provinces and cities in China from December 2009 to December 2011. The strategies for diagnosis and treatment, decided by each hospital respectively, were used for further analysis and comparison of medication, percutaneous coronary intervention (PCI), and end points for efficacy and safety assessment at 9 and 30 days following PCI. Read More

    Angiotensin II Type 1 Receptor Gene A1166C Polymorphism Was Not Associated With Acute Coronary Syndrome in an Iranian Population.
    Iran Red Crescent Med J 2016 Nov 9;18(11):e23942. Epub 2016 Jul 9.
    Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran; Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran.
    Background: There are very limited data for Iranian populations on the predisposing genetic factors for acute coronary syndrome (ACS).

    Objectives: The objective of the present study was to investigate the association of the angiotensin II type 1 receptor (AT1R) gene polymorphism and ACS in an Iranian population.

    Patients And Methods: This cross-sectional study was conducted among 263 subjects (97 men and 166 women). Read More

    Effectiveness of a combination of ezetimibe and statins in patients with acute coronary syndrome and multiple comorbidities: A 6-year population-based cohort study.
    Int J Cardiol 2017 Apr 3;233:43-51. Epub 2017 Feb 3.
    School of Pharmacy, College of Medicine, National Taiwan University, No.33, Linsen S. Rd., Zhongzheng Dist., Taipei 10050, Taiwan; Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, No.33, Linsen S. Rd., Zhongzheng Dist., Taipei 10050, Taiwan; Department of Pharmacy, National Taiwan University Hospital, No.1, Changde St., Zhongzheng Dist., Taipei 10048, Taiwan; Graduate Institute of Pharmaceutical Science, College of Medicine, National Taiwan University, No.33, Linsen S. Rd., Zhongzheng Dist., Taipei 10050, Taiwan. Electronic address:
    Background: The clinical benefits of a combination of statins and ezetimibe in patients with acute coronary syndrome (ACS) were observed in a clinical trial. However, little is known regarding the effectiveness of using statins with or without ezetimibe in patients with ACS and multiple comorbidities in real-world clinical practice.

    Methods: This is a nationwide population-based cohort study using Taiwan National Health Insurance Research Database. Read More

    Features of electrocardiogram in patients with stenosis of the proximal right coronary artery.
    Korean J Intern Med 2017 Feb 14. Epub 2017 Feb 14.
    Department of Emergency Medicine, Dong-A University College of Medicine, Busan, Korea.
    Background/aims: Prediction of lesions of the proximal right coronary artery (pRCA) through electrocardiogram (ECG) is very important because pRCA occlusion has many complications and a high mortality rate, which has frequently been related with right ventricular infarction. The purpose of this study was to devise a screening tool that takes into account multiple leads from a 12-lead ECG to predict the pRCA lesion.

    Methods: A hundred and fifty-eight patients who were diagnosed as acute coronary syndrome and had a pure lesion of RCA or left circumf lex artery (LCX) by ECGs and angiographic findings were enrolled retrospectively. Read More

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