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    1 OF 537

    Should STEMI Patients Receive Opiate Analgesia? The Morphine Paradox.
    Curr Vasc Pharmacol 2018 Jan 17. Epub 2018 Jan 17.
    School of Life and Medical Sciences, Postgraduate Medicine, University of Hertfordshire. United Kingdom.
    Background: The very significant benefit of P2Y12 receptor inhibitor administration in patients with ST-elevation myocardial infarction (STEMI), in reducing future ischaemic events and stent thrombosis, is undisputed. Morphine analgesia is very frequently co-administered to these patients for pain relief, along with antiplatelet therapy, at the time of presentation, and prior to reperfusion with primary percutaneous coronary intervention.

    Methods: Research and online content related to opiates use in STEMI was reviewed. Read More

    Prolonging ticagrelor beyond a year of acute coronary syndrome: worth or harmful?
    Curr Vasc Pharmacol 2018 Jan 16. Epub 2018 Jan 16.
    Semmelweis University - Heart and Vascular Center Budapest. Hungary.
    Platelet activation plays a central role in triggering and complicating acute coronary syndromes, especially in case of stent thrombosis and myocardial infarction. On top of aspirin, P2Y12-inhibitors are successfully used to treat and prevent these events for a duration of one year after an acute coronary episode or 6 months after drug-eluting stent implantation. However, patients with acute coronary syndromes remain at heightened risk for recurrent ischemic events after the recommended durations of P2Y12-inhibitors and therefore, prolonging treatment is often considered in clinical practice. Read More

    Is there a role for oral triple therapy in patients with acute coronary syndromes without atrial fibrillation?
    Curr Vasc Pharmacol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Cardiology, East and North Hertfordshire NHS Trust, Hertfordshire. United Kingdom.
    Background: Acute coronary syndrome (ACS) patients, despite treatment with dual antiplatelet therapy (DAPT), have up to 10% risk of recurrent major adverse cardiac events (MACE) in the short term.

    Methods: Here we review studies using more potent antithrombotic agent combinations to reduce this risk, namely triple therapy (TT) with the addition of an oral anticoagulant, PAR-1 antagonist, or cilostazol to DAPT (mainly aspirin and clopidogrel), and discuss the limitations of trials to date.

    Results: Generally speaking, TT leads to an increase in bleeding. Read More

    What is the role of Cangrelor in patients undergoing PCI?
    Curr Vasc Pharmacol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Cardiology and Cardiovascular Medicine, University Hospital of Tubingen, Tubingen. Germany.
    Dual antiplatelet therapy with aspirin and oral P2Y12-receptor inhibitors prevents ischemic events in patients undergoing percutaneous coronary intervention (PCI). However oral administration of antiplatelet drugs cause delay of onset of platelet inhibition in P2Y12-inhibitor naïve patients. Cangrelor is a novel P2Y12-receptor inhibitor which is administrated intravenously and thus allows immediate antiplatelet inhibition during PCI. Read More

    Mechanical support in cardiogenic shock complicating acute coronary syndrome: ready for prime time?
    Curr Vasc Pharmacol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Cardiology, Hopital Nord, Marseille. France.
    Cardiogenic shock (CS) is a major challenge in current cardiology. Over the last decade, cardiogenic shock mortality has decreased somewhat, but it still remains high, particularly when associated with ischaemic heart disease. The challenges are numerous and include prevention, accurate diagnosis, prompt management and effective therapies to support a failing heart and prevent multi-organ failure. Read More

    Improving patient adherence to secondary prevention medications 6 months after an acute coronary syndrome: observational cohort study.
    Intern Med J 2018 Jan 18. Epub 2018 Jan 18.
    School Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia.
    Background: Most patients are recommended secondary prevention pharmacotherapies following an acute coronary syndrome (ACS).

    Aims: To identify predictors of adherence at 6 months and strategies to improve adherence to these therapies. Design and methods Patients in the CONCORDANCE registry who were discharged on evidence-based medications were stratified into those receiving ≥75% ('adherent') or <75% ('non-adherent') of indicated medications at 6 months. Read More

    Evaluation of serum cysteine-rich protein 61 levels in patients with coronary artery disease.
    Biomark Med 2018 Jan 18. Epub 2018 Jan 18.
    Division of Cardiology, Shenzhen Tenth People's Hospital, Shenzhen, Guangdong, China.
    Aim: The aim is to evaluate serum cysteine-rich protein 61 (Cyr61) levels in patients with coronary artery disease (CAD).

    Patients & Methods: Serum Cyr61 levels were measured in 180 patients with CAD and 74 participants without CAD.

    Results: Serum Cyr61 levels were significantly higher in CAD patients. Read More

    Design and Rationale for comParison Between ticagreLor and clopidogrEl on mIcrocirculation in Patients with Acute cOronary Syndrome Undergoing Percutaneous Coronary Intervention (PLEIO) Trial.
    J Cardiovasc Transl Res 2018 Jan 17. Epub 2018 Jan 17.
    Regional Cardiocerebrovascular Center, Division of Cardiology, Department of Internal Medicine, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Republic of Korea.
    It has been previously demonstrated that ticagrelor can reduce mortality compared to clopidogrel in acute coronary syndrome (ACS) patients. However, the mechanism for this mortality reduction remains uncertain. The objective of the present study is to assess the impact of chronic ticagrelor treatment on microvascular circulation. Read More

    Young Asian men with diabetes have the highest risk for acute coronary events: retrospective cohort analyses.
    JRSM Open 2018 Jan 8;9(1):2054270417732699. Epub 2018 Jan 8.
    Department of Diabetes, Endocrinology and Lipid Metabolism, City Hospital, Birmingham B18 7QH, UK.
    Objective: To understand the ethnic differences in coronary heart disease risk among inpatients with diabetes following acute coronary syndrome.

    Design: Single-centre retrospective cohort-analysis of patients with type II diabetes over a six-year period receiving standard care.

    Setting: Birmingham, UK. Read More

    Healthcare provider-led interventions to support medication adherence following ACS: a meta-analysis.
    Open Heart 2017 22;4(2):e000685. Epub 2017 Dec 22.
    Institute of Pharmaceutical Science, King's College London, London, UK.
    We conducted a systematic review and meta-analysis to determine the effectiveness of healthcare provider-led (HCPs) interventions to support medication adherence in patients with acute coronary syndrome (ACS). A systematic search of Cochrane Library, Medline, EMBASE, PsycINFO, Web of Science, IPA, CINAHL, ASSIA, OpenGrey, EthOS, WorldCat and PQDT was undertaken. Interventions were deemed eligible if they included adult ACS patients, were HCP-led, measured medication adherence and randomised participants to parallel groups. Read More

    Effect of Acute Coronary Syndrome Probability on Diagnostic and Prognostic Performance of High-Sensitivity Cardiac Troponin.
    Clin Chem 2018 Jan 17. Epub 2018 Jan 17.
    Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland;
    Background: There is concern that high-sensitivity cardiac troponin (hs-cTn) may have low diagnostic accuracy in patients with low acute coronary syndrome (ACS) probability.

    Methods: We prospectively stratified patients presenting with acute chest discomfort to the emergency department (ED) into 3 groups according to their probability for ACS as assessed by the treating ED physician using a visual analog scale-≤10%, 11% to 79%, and ≥80%-reviewing all information available at 90 min. hs-cTnT and hs-cTnI concentrations were determined in a blinded fashion. Read More

    Clinical Laboratory Practice Recommendations for the Use of Cardiac Troponin in Acute Coronary Syndrome: Expert Opinion from the Academy of the American Association for Clinical Chemistry and the Task Force on Clinical Applications of Cardiac Bio-Markers of the International Federation of Clinical Chemistry and Laboratory Medicine.
    Clin Chem 2018 Jan 17. Epub 2018 Jan 17.
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center and University of Minnesota, Minneapolis, MN.
    This document is an essential companion to the third iteration of the National Academy of Clinical Biochemistry [NACB,8 now the American Association for Clinical Chemistry (AACC) Academy] Laboratory Medicine Practice Guidelines (LMPG) on cardiac markers. The expert consensus recommendations were drafted in collaboration with the International Federation of Clinical Chemistry and Laboratory Medicine Task Force on Clinical Applications of Bio-Markers (IFCC TF-CB). We determined that there is sufficient clinical guidance on the use of cardiac troponin (cTn) testing from clinical practice groups. Read More

    High Loading Dose of Atorvastatin for the Prevention of Serum Creatinine and Cystatin C-Based Contrast-Induced Nephropathy Following Percutaneous Coronary Intervention.
    Angiology 2018 Jan 1:3319717750903. Epub 2018 Jan 1.
    1 Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.
    The aim of this study is to assess the efficacy of high-dose atorvastatin on the prevention of contrast-induced nephropathy (CIN) in patients with acute coronary syndrome (ACS) undergoing percutaneous intervention and observe the incidence of cystatin C (CyC)-based CIN. A total of 496 patients with ACS were randomly assigned to either the control group (247 patients receiving conventional dose atorvastatin 10 mg daily from 1 day before to 3 days after contrast administration) or the high-dose atorvastatin group (249 patients receiving atorvastatin 40 mg daily for the same perioperative period). The baseline characteristics of the 2 groups were similar. Read More

    [Takotsubo cardiomyopathy and catatonia in a patient with psychotic depression].
    Tijdschr Psychiatr 2018 ;60(1):55-59
    Takotsubo cardiomyopathy (tcmp) is an acute, reversible disruption of the left ventricular systolic function. In many respects the clinical presentation closely resembles acute coronary syndromes (myocardial infarction). tcmp is a syndrome with a pathophysiology that is not fully understood and which seems to be closely associated with psychiatric disorders or psychological problems. Read More

    Clinical characteristics and outcomes of acute coronary syndrome patients with intra-aortic balloon pump inserted in intensive cardiac care unit of a tertiary clinic.
    Turk Kardiyol Dern Ars 2018 Jan;46(1):10-17
    Department of Cardiology, Haydapaşa Sultan Abdulhamid Han Training and Research Hospital, İstanbul, Turkey.
    Objective: An intra-aortic balloon pump (IABP) is a mechanical support device that is used in addition to pharmacological treatment of the failing heart in intensive cardiac care unit (ICCU) patients. In the literature, there are limited data regarding the clinical characteristics and in-hospital outcomes of acute coronary syndrome patients in Turkey who had an IABP inserted during their ICCU stay. This study is an analysis of the clinical characteristics and outcomes of these acute coronary syndrome patients. Read More

    Acute myocardial infarction shortly after valve-in-valve transcatheter aortic valve implantation successfully managedwith challenging percutaneous coronary intervention.
    Turk Kardiyol Dern Ars 2018 Jan;46(1):61-65
    Department of Cardiology, Trakya University Faculty of Medicine, Edirne, Turkey.
    In recent years, transcatheter aortic valve implantation (TAVI) has been considered a novel option for the management of surgically high-risk patients requiring aortic valve replacement. Presently described is a case of acute coronary syndrome (ACS) managed with a challenging primary percutaneous coronary intervention (PCI) shortly after a valve-in-valve TAVI intervention. This case highlights 2 important issues: PCI may be an option for the management of coronary heart disease in patients after TAVI even in the setting of demanding features associated with coronary osteal engagement, and secondly, TAVI may serve as a potential risk factor for future coronary ischemic syndromes, largely due to its potential adverse effects on coronary flow dynamics, etc. Read More

    Kidney Biomarkers and Decline in eGFR in Patients with Type 2 Diabetes.
    Clin J Am Soc Nephrol 2018 Jan 16. Epub 2018 Jan 16.
    Division of Cardiometabolic Trials, Baim Institute for Clinical Research, Boston, Massachusetts.
    Background And Objectives: Biomarkers may improve identification of individuals at risk of eGFR decline who may benefit from intervention or dialysis planning. However, available biomarkers remain incompletely validated for risk stratification and prediction modeling.

    Design, Setting, Participants, & Measurements: We examined serum cystatin C, urinary kidney injury molecule-1 (uKIM-1), and urinary neutrophil gelatinase-associated lipocalin (UNGAL) in 5367 individuals with type 2 diabetes mellitus and recent acute coronary syndromes enrolled in the Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care (EXAMINE) trial. Read More

    Selection of P2Y12 inhibitor in percutaneous coronary intervention and/or acute coronary syndrome.
    Prog Cardiovasc Dis 2018 Jan 12. Epub 2018 Jan 12.
    Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute, Falls Church, VA, USA. Electronic address:
    The P2Y12 receptor plays a critical role in the amplification of platelet aggregation in response to various agonists and stable thrombus generation at the site of vascular injury leading to deleterious ischemic complications. Therefore, treatment with a P2Y12 receptor blocker is a major effective strategy to prevent ischemic complications in high -risk patients with acute coronary syndrome (ACS) and patients undergoing percutaneous coronary intervention (PCI). The determination of optimal platelet inhibition is based on maximizing antithrombotic properties while minimizing bleeding risk and is critically dependent on individual patient's propensity for thrombotic and bleeding risks. Read More

    Anticoagulation in acute coronary syndrome-state of the art.
    Prog Cardiovasc Dis 2018 Jan 12. Epub 2018 Jan 12.
    Sorbonne University, ACTION Group, INSERM UMRS 1166, Institut de Cardiologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France. Electronic address:
    Early intravenous anticoagulation is the corner stone treatment of patients admitted with an acute coronary syndrome: it antagonizes the ongoing coronary thrombosis and facilitates the percutaneous coronary intervention, hence a reduction of mortality and acute stent thrombosis. Unfractionated heparin, enoxaparin, bivalirudin and fondaparinux have been extensively studied in large randomized control trials and meta-analyses with the same objective: reducing the ischemic burden without hiking hemorrhagic events. This conundrum is evolving along the generalization of the radial-artery access, the use of potent P2Y12 and the trend towards a tailored approach regarding the ischemic and bleeding balance. Read More

    An alternative tool for triaging patients with possible acute coronary symptoms before admission to a chest pain unit.
    Am J Emerg Med 2017 Dec 13. Epub 2017 Dec 13.
    Department of Cardiology, Far Eastern Memorial Hospital, 21 Sec. 2, Nanya S. Rd., New Taipei City, Taiwan 220.
    Objective: This study aimed to develop a triage tool to more effectively triage possible ACS patients presenting to the emergency department (ED) before admission to a protocol-driven chest pain unit (CPU).

    Methods: Seven hundred ninety-three clinical cases, randomly selected from 7962 possible ACS cases, were used to develop and test an ACS triage model using cluster analysis and stepwise logistic regression.

    Results: The ACS triage model, logit (suspected ACS patient)=-5. Read More

    Antiphosphatidylserine/prothrombin (aPS/PT) antibodies are associated with Raynaud phenomenon and migraine in primary thrombotic antiphospholipid syndrome.
    Lupus 2018 Jan 1:961203317751644. Epub 2018 Jan 1.
    1 John Paul II Hospital, Kraków, Poland.
    Objectives Antibodies to phosphatidylserine/prothrombin complex (aPS/PT) detectable in sera of some patients with antiphospholipid syndrome (APS) have been shown to correlate with thrombosis. However, associations of aPS/PT antibodies with APS related disorders remain unclear. Aim To evaluate whether there are any associations between aPS/PT antibodies and Raynaud phenomenon, migraine and/or valvular lesions in primary thrombotic APS (PAPS). Read More

    Kounis Syndrome Induced by Oral Intake of Diclofenac Potassium.
    Iran J Allergy Asthma Immunol 2017 Dec;16(6):565-568
    Department of Emergency Medicine, School of Medicine, Duzce University, Duzce, Turkey.
    An acute coronary syndrome (ACS) occurring during the course of an allergic reaction is called Kounis syndrome (KS). The second case of KS induced by diclofenac potassium (DP) is presented in this report. A 67-year-old man was brought to our emergency department with the possible diagnosis of anaphylactic shock by the ambulance staff. Read More

    Rosuvastatin Improves Vaspin Serum Levels in Obese Patients with Acute Coronary Syndrome.
    Diseases 2018 Jan 16;6(1). Epub 2018 Jan 16.
    Department of Pharmacology, Toxicology, and Medicine, College of Medicine Al-Mustansiriyah University, P.O. Box 14132 Baghdad, Iraq.
    Adipose tissue-derived serine protease inhibitor (vaspin), which has endocrine and local roles in atherosclerosis growth, is also synthesized by adipose tissue; it was found that vaspin was negatively correlated with blood pressure in obese patients, while vaspin levels were decreased in endothelial dysfunction. The aim of the present study was to determine rosuvastatin modulation effects on serum vaspin levels in acute coronary syndrome (ACS) with class I obesity. A total number of seventy patients with acute coronary syndrome previously and currently treated with rosuvastatin was compared to 40 patients with IHD not treated by rosuvastatin as a control. Read More

    2-Year Outcomes of High Bleeding Risk Patients with Acute Coronary Syndrome After Biolimus-A9 Polymer-Free Drug-Coated Stents: a Leaders Free Sub-study.
    EuroIntervention 2018 Jan 16. Epub 2018 Jan 16.
    Contilia Heart and Vascular Centre, Elisabeth Krankenhaus Essen, Klara-Kopp-Weg 1, 45138 Essen, Germany.
    Aims: The Leaders Free ACS sub-study demonstrated that a Biolimus-A9 drug coated stent (DCS) is more effective and safer than a bare metal stent (BMS) at 12 months follow up in high-bleeding risk (HBR) patients with acute coronary syndrome (ACS). This analysis extends the follow-up to 2 years.

    Methods And Results: A total of 659 ACS patients with HBR were included and received one month of dual antiplatelet therapy only. Read More

    The role of colchicine in pericardial syndromes.
    Curr Pharm Des 2018 Jan 15. Epub 2018 Jan 15.
    First Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens. Greece.
    Background: Colchicine is an old drug originally employed for the treatment of inflammatory disorders such as acute gout and familiar Mediterranean fever.

    Methods: In the past few decades, colchicine has been at the forefront of the pharmacotherapy of several cardiac diseases, including acute and recurrent pericarditis, coronary artery disease, prevention of atrial fibrillation and heart failure. In this review, we have summarized the current evidence based medicine and guidelines recommendations in the specific context of pericardial syndromes. Read More

    Early prognosis and predictor analysis for positive coronary angiography after out-of-hospital cardiac arrest (OHCA).
    Acta Cardiol 2018 Jan 16:1-8. Epub 2018 Jan 16.
    a Service de Pathologie Cardiovasculaire , Cliniques Universitaires de Mont-Godinne , Yvoir , Belgique.
    Background: Key predictors of survival after OHCA have been described in the literature. Current guidelines recommend emergency angiography in patients without an obvious extra-cardiac cause of arrest. However, the value of this strategy is debated. Read More

    [Diagnostic and prognostic biomarkers in acute coronary syndrome].
    Vnitr Lek 2018 ;63(12):935-944
    Acute myocardial infarction (AMI) is an important cause of mortality and morbidity worldwide. Early diagnostics of this disease helps in the appropriate treatment of patients. Great attention is paid to the diagnostic and risk stratification of patients according to circulating biomarkers. Read More

    Plasmatic MicroRNA Signatures in Elderly People with Stable and Unstable Angina.
    Int Heart J 2018 Jan 15. Epub 2018 Jan 15.
    Department of Cardiology, Peking University People's Hospital.
    We aimed to investigate the distinctive miRNA profiles in the plasma of elderly patients with unstable angina (UA) and stable angina (SA), and to find more effective markers of UA in elderly people. We compared miRNA expression levels in plasma samples from 10 elderly patients with UA and 10 elderly patients with SA by using microarray-based miRNA chip, and then performed validation with Real-time PCR. Mir-1202, mir-1207-5p, and mir-1225-5p showed a statistically significant down-regulation (P < 0. Read More

    Optical Coherence Tomography Guidance in Management of Acute Coronary Syndrome Caused by Plaque Erosion.
    Circ J 2018 Jan 13. Epub 2018 Jan 13.
    Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University.
    For several decades, most physicians have believed that acute coronary syndrome (ACS) is caused by coronary thrombosis resulting from rupture of vulnerable plaque characterized by a thin fibrous cap overlying a large necrotic core and massive inflammatory cell infiltration. However, nearly one-third of ACS cases are caused by plaque erosion characterized by intact fibrous cap, less or absent necrotic core, less inflammation, and large lumen. Because of the limitations of current imaging modalities, including angiography and intravascular ultrasound, the importance of plaque erosion as a cause of acute coronary events is less well known. Read More

    Predictive value of neutrophil to lymphocyte ratio in long-term outcomes of left main and/or three-vessel disease in patients with acute myocardial infarction.
    Catheter Cardiovasc Interv 2018 Jan 13. Epub 2018 Jan 13.
    State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Road No. 167, Xicheng District, Beijing, 100037, People's Republic of China.
    Objectives: We sought to evaluate the independent predictive value of left main disease (LMD) and/or three-vessel disease (LMD/3VD) in acute myocardial infarction (AMI) patients.

    Background: Patients with acute coronary syndrome resulting from LMD and/or three-vessel disease (LMD/3VD) are at the highest risk of adverse cardiovascular events. Neutrophil to lymphocyte ratio (NLR) has been proposed as a marker of cardiovascular risk, but the prognostic value of NLR in patients with LMD/3VD who underwent percutaneous coronary intervention (PCI) is not clearly defined. Read More

    Osteoprotegerin Is Associated With Major Bleeding But Not With Cardiovascular Outcomes in Patients With Acute Coronary Syndromes: Insights From the PLATO (Platelet Inhibition and Patient Outcomes) Trial.
    J Am Heart Assoc 2018 Jan 12;7(2). Epub 2018 Jan 12.
    Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.
    Background: Elevated levels of osteoprotegerin, a secreted tumor necrosis factor-related molecule, might be associated with adverse outcomes in patients with coronary artery disease. We measured plasma osteoprotegerin concentrations on hospital admission, at discharge, and at 1 and 6 months after discharge in a predefined subset (n=5135) of patients with acute coronary syndromes in the PLATO (Platelet Inhibition and Patient Outcomes) trial.

    Methods And Results: The associations between osteoprotegerin and the composite end point of cardiovascular death, nonprocedural spontaneous myocardial infarction or stroke, and non-coronary artery bypass grafting major bleeding during 1 year of follow-up were assessed by Cox proportional hazards models. Read More

    Differences in the CT findings between vulnerable plaque and culprit lesions in acute coronary syndrome.
    J Cardiovasc Comput Tomogr 2018 Jan 5. Epub 2018 Jan 5.
    Department of Radiology, University of Maryland, Baltimore, MD, USA.
    Background: The CT finding of "vulnerable plaque" is widely regarded as similar to that of a culprit lesion in an acute coronary syndrome (ACS). However, this hypothesis may not be accurate, since "vulnerable plaques" may substantially change their morphology when they rupture to cause an ACS.

    Methods: We retrospectively evaluated coronary CT angiography data sets of 25 patients with ACS who had vulnerable (n = 10) or culprit plaques (n = 15). Read More

    Plaque erosion: a new in vivo diagnosis and a potential major shift in the management of patients with acute coronary syndromes.
    Eur Heart J 2018 Jan 9. Epub 2018 Jan 9.
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, Boston, MA 02114, USA.
    Pathology and in vivo imaging studies have identified superficial plaque erosion as a frequent and important mechanism underlying acute coronary syndromes (ACS). In contrast with plaque rupture, the pathophysiological mechanisms leading to plaque erosion remain poorly understood. The advent of intravascular imaging techniques, particularly optical coherence tomography, has aided understanding of this mode of ACS in vivo by complementing previous insights from pathology studies. Read More

    Serum lipoprotein(a) predicts acute coronary syndromes in patients with severe carotid stenosis.
    Eur J Clin Invest 2018 Jan 11. Epub 2018 Jan 11.
    First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 Viale Benedetto XV, 16132, Genoa, Italy.
    Different cut-off values of serum lipoprotein(a) [Lp(a)] were recently identified in order to better stratify cardiovascular risk categories. Both pathophysiological and prognostic values of Lp(a) remain unclear. Here, the prognostic value of Lp(a) and its correlation with intraplaque features were assessed in patients with severe carotid artery stenosis undergoing endarterectomy (n=180). Read More

    Clinical Outcomes of Patients Undergoing Rotational Atherectomy Followed by Drug-eluting Stent Implantation: A Single-center Real-world Experience.
    Heart Views 2017 Oct-Dec;18(4):115-120
    Department of Invasive Cardiology, Philippine Heart Center, Metro Manila, Philippines.
    Background: Rotational atherectomy (RA) is used to improve procedural success of percutaneous catheter interventions (PCIs) of complex and heavily calcified coronary lesions. We report the clinical experience and outcomes in our institution with the use of RA, followed by drug-eluting stent implantation.

    Materials And Methods: Data of 81 patients treated with PCI and adjunctive RA were analyzed. Read More

    Diagnostic Performance of the Instantaneous Wave-Free Ratio: Comparison With Fractional Flow Reserve.
    Circ Cardiovasc Interv 2018 Jan;11(1):e004613
    From the Division of Cardiology, Department of Medical and Surgical Sciences (S.D.R., A.P., C.I.) and URT-CNR of IFC (C.I.), Magna Graecia University, Catanzaro, Italy; and National Heart and Lung Institute, Imperial College London, United Kingdom (R.P., J.E.D.).
    Background: Aim of the present study was to perform a meta-analysis of all available studies comparing the instantaneous wave-free ratio (iFR) with fractional flow reserve (FFR).

    Methods And Results: Published trials comparing the iFR with FFR were searched for in PubMed, Google Scholar, and Scopus electronic databases. A total of 23 studies were available for the analysis, including 6381 stenoses. Read More

    Cardiac rehabilitation in patients with acute coronary syndrome with primary percutaneous coronary intervention is associated with improved 10-year survival.
    Eur Heart J Qual Care Clin Outcomes 2018 Jan 9. Epub 2018 Jan 9.
    Department of Cardiology, Thoraxcentre, Erasmus MC, Rotterdam, The Netherlands.
    Aims: We aimed to assess the effects of a multidisciplinary cardiac rehabilitation program (CR) on survival after treatment with primary percutaneous coronary intervention (pPCI) for acute coronary syndrome (ACS).

    Methods And Results: Using propensity matching analysis, a total of 1,159 patients undergoing CR were 1:1 matched with ACS patients who did not undergo CR and survived at least 60 days. Kaplan-Meier analyses and multivariate Cox regression analysis were applied to study differences in survival. Read More

    Validation of contemporary risk scores in predicting coronary thrombotic events and major bleeding in patients with acute coronary syndrome after drug-eluting stent implantations.
    Catheter Cardiovasc Interv 2018 Jan 11. Epub 2018 Jan 11.
    Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China.
    Objectives: We aimed to assess the prognostic ability of the ST score, DAPT score, and PARIS score in a Chinese population.

    Background: Recently, several risk scores predicting the long-term risk of coronary thrombotic events [CTE, defined as the composite of definite or probable stent thrombosis (ST) and myocardial infarction] and bleeding have been developed and initially validated in Western populations.

    Methods: A total of 6,088 consecutive patients with acute coronary syndrome (mean age 58. Read More

    Impact of triple antithrombotic therapy in patients with acute coronary syndrome undergoing percutaneous coronary intervention in real-world practice.
    J Geriatr Cardiol 2017 Nov;14(11):679-687
    University Clinic of Cardiology, Skopje, Macedonia.
    Objective: The optimal antithrombotic regimen for patients on oral anticoagulation (OAC) after acute coronary syndrome (ACS) and percutaneous coronary intervention (PCI) remains debated. This study sought to evaluate the efficacy and safety of OAC plus clopidogrel with or without aspirin in a real-world setting.

    Methods: We retrospectively analyzed data from an international, multi-center registry between 2003 and 2014 (n = 15,401). Read More

    New-onset Takayasu's Arteritis as Acute Myocardial Infarction.
    Intern Med 2018 Jan 11. Epub 2018 Jan 11.
    Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University, Japan.
    We herein report the case of a 25-year-old Japanese woman with left-main-trunk acute myocardial infarction (LMT-AMI). She had cardiogenic shock, so emergency percutaneous intervention was performed. Intravascular ultrasound of LMT-AMI showed that the three-layered structure of the intima, tunica media, and adventitia was not clearly visible, and the vessel was concentrically thickened; unstable plaque and calcification were not seen. Read More

    Explaining the decline in coronary heart disease mortality rates in the Slovak Republic between 1993-2008.
    PLoS One 2018 10;13(1):e0190090. Epub 2018 Jan 10.
    Department of Public Health and Policy, Institute of Psychology, Health & Society, University of Liverpool, Liverpool, United Kingdom.
    Objective: Between the years 1993 and 2008, mortality rates from coronary heart disease (CHD) in the Slovak Republic have decreased by almost one quarter. However, this was a smaller decline than in neighbouring countries. The aim of this modelling study was therefore to quantify the contributions of risk factor changes and the use of evidence-based medical therapies to the CHD mortality decline between 1993 and 2008. Read More

    Cardiometabolic Risk Factors in Acute Coronary Syndrome with Special Reference to Non-HDL Cholesterol.
    J Assoc Physicians India 2017 Oct;65(10):30-36
    Associate Professor, Department of Medicine, NKP Salve Institute of Medical Science and Research, Nagpur, Maharashtra.
    Introduction: Cardiovascular diseases are becoming the major cause of morbidity and mortality in most of the developing countries including India. Cardiometabolic risk factors play a vital role in causation of coronary artery disease. Present study was carried out to investigate the role of various risk factors in the occurrence of coronary artery disease (CAD) in population from Central India. Read More

    Percutaneous Intervention of a Single Coronary Artery in the Setting of Acute Coronary Syndrome.
    Cardiol Res 2017 Dec 22;8(6):349-353. Epub 2017 Dec 22.
    University Heart Center, University Hospital Zurich, Zurich, Switzerland.
    Performing intervention of a single coronary artery (SCA) is challenging and technically difficult since a severe complication may be catastrophic if occurred. It requires a proper selection of instruments and well experienced operator to perform the intervention. However, a definitive standardization treatment for those patients is difficult; each case should be treated individually, according to the anatomical variations. Read More

    Giant coronary aneurysm culprit of an acute coronary syndrome.
    Rev Port Cardiol 2018 Jan 6. Epub 2018 Jan 6.
    Cardiovascular Institute, Hospital Universitario Clínico San Carlos, Madrid, Spain.
    A 66-year-old male ex-smoker with hypertension, type 2 diabetes mellitus and dyslipidaemia was admitted due to a non-ST segment elevation myocardial infarction. The catheterisation depicted an extensive and calcified disease: chronic total obstruction of the right coronary and severe disease with a giant aneurysm at the first marginal branch as the culprit vessel. After discussion, the right coronary was treated before the circumflex-giant aneurysm was closed with a stent graft and its multiple severe stenosis solved with two drug-eluting stents. Read More

    Could the screening for correct oral health reduce the impact of death due to bolus asphyxia in adult patients? A forensic case report.
    Med Hypotheses 2018 Jan 23;110:23-26. Epub 2017 Oct 23.
    Chair of Legal Medicine, University "Magna Graecia" of Catanzaro, Italy.
    Introduction: "Bolus death" or "Café Coronary syndrome" refers to death due to asphyxia caused by an occlusion of the upper airways due to food. In this kind of asphyxia, the food bolus obstructs the larynx or the bronchial branches. This kind of event often affects subjects with acute intoxication due to alcohol or drugs, or with edentulism and with neurological or psychiatric diseases. Read More

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