Search Our Scientific Publications & Authors

PLoS One 2021 11;16(6):e0249338. Epub 2021 Jun 11.

Department of Computer Science, Chungbuk National University, Cheongju, Chungbuk, South Korea.

Objective: Some researchers have studied about early prediction and diagnosis of major adverse cardiovascular events (MACE), but their accuracies were not high. Therefore, this paper proposes a soft voting ensemble classifier (SVE) using machine learning (ML) algorithms.

Methods: We used the Korea Acute Myocardial Infarction Registry dataset and selected 11,189 subjects among 13,104 with the 2-year follow-up. Read More

Curr Pharm Des 2021 Jun 10. Epub 2021 Jun 10.

University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Medical Faculty, University of Skopje, Skopje, Macedonia.

Metabolic syndrome (MetS) represents a cluster of metabolic disorders that arise from insulin resistance (IR) and adipose tissue dysfunction. As a consequence, there is an increased risk for type 2 diabetes mellitus and atherosclerotic cardiovascular disease (CVD). MetS is associated with a 2-fold increase in cardiovascular outcomes. Read More

Adv Ther 2021 Jun 11. Epub 2021 Jun 11.

AstraZeneca Medical Affairs, Ho Chi Minh City, Vietnam.

Introduction: The PLATelet inhibition and patient Outcomes (PLATO) trial (NCT00391872) demonstrated that ticagrelor compared to clopidogrel significantly reduced the rate of death from cardiovascular causes, myocardial infarction or stroke in patients with acute coronary syndrome (ACS). The aim of this study is to analyze the long-term cost-effectiveness of ticagrelor compared to clopidogrel in ACS patients from a Vietnamese healthcare payers' perspective.

Methods: A two-part cost-effectiveness model was developed to estimate long-term costs and quality-adjusted life-years (QALY). Read More

Clin Cardiol 2021 Jun 11. Epub 2021 Jun 11.

CHU de Caen Normandie, Service de Cardiologie, Caen, France.

Objectives: We sought to investigate the safety and potential benefit of administrating glycoprotein IIb-IIIa inhibitors (GPIs) on top of more potent P2Y12 inhibitors.

Background: A number of clinical trials, performed at a time when pretreatment and potent platelet inhibition was not part of routine clinical practice, have documented clinical benefits of GPI in ST-segment elevation myocardial infarction (STEMI) patients at the cost of a higher risk of bleeding.

Methods: We used the data of a prospective, ongoing registry of patients admitted for STEMI in our center. Read More

Echocardiography 2021 Jun 10. Epub 2021 Jun 10.

Department of Cardiovascular Medicine, Lady Davis Carmel Medical Center, Haifa, Israel.

Aims: We have previously shown that 2-dimentional strain is not a useful tool for ruling out acute coronary syndrome (ACS) in the emergency department (ED). The aim of the present study was to determine whether in patients with suspected ACS, global longitudinal strain (GLS), measured in the ED using 2-dimensional strain imaging, can predict long-term outcome.

Methods: Long-term (median 7. Read More

Cardiovasc Endocrinol Metab 2021 Jun 21;10(2):113-119. Epub 2020 Sep 21.

Department of Cardiology, Barzilai University Medical Center, Ashkelon and The Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel.

Background: There is conflicting data regarding the association between low levels of plasma vitamin D and ischemic heart disease. We aimed to investigate the relationship between plasma vitamin D levels and heart valve calcification in hospitalized patients with ischemic heart disease versus non-ischemic heart disease controls.

Methods: A prospective case-control study comprising two age and gender-matched groups. Read More

Eur Heart J Case Rep 2021 Mar 31;5(3):ytab110. Epub 2021 Mar 31.

Heart and Lung Centre, New Cross Hospital, Royal Wolverhampton NHS Trust, Wolverhampton WV10 0QP, UK.

Eur Heart J Case Rep 2021 Mar 16;5(3):ytab095. Epub 2021 Mar 16.

Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Background: Lipid-rich plaques (LRP) in the non-culprit lesions (NCL) in patients with the acute coronary syndrome may trigger lesion-related, adverse cardiovascular events. Aggressive lipid-lowering therapy may stabilize LRP; however, the times of stabilization remain undefined.

Case Summary: A 60-year-old man presented with unstable angina. Read More

Eur Heart J Case Rep 2021 Mar 10;5(3):ytab077. Epub 2021 Mar 10.

Cardiovascular Division, University of Nebraska Medical Center, 982265 Nebraska Medical Center, Omaha, NE 68198, USA.

Background: Coronary embolism is a rare cause of myocardial infarction (MI). We present a case report which emphasizes the importance of intracoronary imaging in these cases to identify the pathophysiological mechanism of MI.

Case Summary: A 53-year-old male with no past medical history presented to the hospital with typical angina. Read More

Eur Heart J Case Rep 2021 Mar 29;5(3):ytab056. Epub 2021 Mar 29.

Department of Cardiology, Instituto Cardiovascular, Hospital Clínico San Carlos, C/Profesor Martín Lagos S/N, 28040 Madrid, Spain.

Background: Coronary subclavian steal syndrome (CSSS) is an uncommon complication observed in patients after coronary artery bypass surgery with left internal mammary artery (LIMA) grafts. It is defined as coronary ischaemia due to reversal flow from the LIMA to the left subclavian artery (SA) when a proximal left SA stenosis is present. In practice, the entire clinical spectrum of ischaemic heart disease, ranging from asymptomatic patients to acute myocardial infarction, may be encountered. Read More

Eur Heart J Case Rep 2021 Mar 15;5(3):ytab051. Epub 2021 Mar 15.

Cardiothoracic and Vascular Department, Cardiology Unit, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Heart Tower-Room 807, Largo Città d'Ippocrate, 84131 Salerno, Italy.

Background: Takotsubo syndrome (TTS) is an acute and transient heart failure syndrome due to reversible myocardial dysfunction characterized by a wide spectrum of possible clinical scenarios. About one-fifth of TTS patients experience adverse in-hospital events. Thromboembolic complications, especially stroke, have been reported, albeit in a minority of patients. Read More

Rev Port Cardiol 2021 Jun 7. Epub 2021 Jun 7.

Cardiology Department, Centro Hospitalar Universitário de São João, Porto, Portugal.

Introduction: Since 2011, the European guidelines have included a specific low-density lipoprotein cholesterol (LDL-C) target, <70 mg/dl, for very high cardiovascular risk (CVR) patients. However, registries have shown unsatisfactory results in obtaining this level of adequate lipid control.

Objectives: To assess temporal trends in the use of lipid-lowering therapy (LLT) and attainment of adequate control in very high CVR patients since 2011. Read More

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):573-577

Department of Coronary Care Unit, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, China. Corresponding author: Liu Wenxian, Email:

Objective: To investigate the predictive value of plasma high-sensitivity C-reactive protein/albumin ratio (HCRP/ALB) for the death in patients with acute coronary syndrome (ACS).

Methods: The clinical data of patients with ACS [including unstable angina (UA), non-ST segment elevation myocardial infarction (NSTEMI), ST segment elevation myocardial infarction (STEMI)] admitted to Beijing Anzhen Hospital Affiliated to Capital Medical University from January 2018 to August 2020 were retrospectively analyzed. The plasma HCRP and ALB were recorded and the HCRP/ALB ratio was calculated. Read More

Pharmacol Res 2021 Jun 7:105715. Epub 2021 Jun 7.

Department of Medical Sciences, University of Turin, Turin, Italy. Electronic address:

The relevance of extracellular vesicles (EV) as mediators of cardiac damage or recovery upon Ischemia Reperfusion Injury (IRI) and Remote Ischemic PreConditioning (RIPC) is controversial. This study aimed to investigate whether serum-derived EV, recovered from patients with Acute Coronary Syndrome (ACS) and subjected to the RIPC or sham procedures, may be a suitable therapeutic approach to prevent IRI during Percutaneous-Coronary-Intervention (PCI). A double-blind, randomized, sham-controlled study (NCT02195726) has been extended, and EV were recovered from 30 patients who were randomly assigned (1:1) to undergo the RIPC- (EV-RIPC) or sham-procedures (EV-naive) before PCI. Read More

Eur Heart J Case Rep 2021 May 10;5(5):ytab181. Epub 2021 May 10.

Department of Cardiology, University Hospital of Wales, Heath Park, Cardiff CF14 4XN, U K.

Background: Coronary stent avulsion is a rare, infrequently reported complication of percutaneous coronary intervention (PCI) with no consensus on management options.

Case Summary: This case series presents three descriptions of iatrogenic coronary stent avulsions, and three different bailout management strategies. All patients presented with acute coronary syndrome and required PCI. Read More

Eur Heart J Case Rep 2021 May 24;5(5):ytab142. Epub 2021 May 24.

Department of Cardiovascular Medicine, McLaren Macomb Regional Medical Center, 1000 Harrington Street, Mount Clemens, MI 48043, USA.

Background: Takotsubo cardiomyopathy (TCM) can clinically present as an acute coronary syndrome; however, the former has regional wall motion abnormalities that extend beyond a single coronary vascular territory without any plaque rupture. Takotsubo cardiomyopathy classically involves apical ballooning of left ventricle (LV). It is uncommon for TCM to present as cardiopulmonary arrest (CPA) along with third-degree atrioventricular (AV) block. Read More

Front Psychiatry 2021 14;12:621284. Epub 2021 May 14.

Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Acute coronary syndromes (ACS) induce post-traumatic stress symptoms (PTSS) in one out of eight patients. Effects of preventive interventions, the course and potential moderators of ACS-induced PTSS are vastly understudied. This study explored whether a preventive behavioral intervention leads to a decrease in myocardial infarction (MI)-induced PTSS between two follow-up assessments. Read More

BMJ Case Rep 2021 Jun 9;14(6). Epub 2021 Jun 9.

Department of Cardiology, CHUV, Lausanne, Switzerland.

Lithium is frequently used in the treatment of bipolar disorders and is known to induce ECG alterations. This case study describes various patterns of lithium-induced ECG modifications in a patient with acute-on-chronic lithium intoxication. Clinicians should be familiar with this problem as it can have life-threatening consequences and lead to important changes in patient's management. Read More

Ann Palliat Med 2021 May;10(5):5763-5766

Hunan University of Chinese Medicine, Changsha, China.

Background: Acute coronary syndrome (ACS), which usually results from the buildup of fatty deposits (plaques) in and on the walls of coronary arteries, remains a major cause of morbidity and mortality worldwide. In the present systematic review, we aim to evaluate the efficacy and safety of adding traditional Chinese medicine (TCM) to standard western medicine to treat patients with ACS.

Methods: A systematic search was carried out in the China National Knowledge Infrastructure (CNKI; Chinese), the Chinese Biomedical Literature Disk Database CBMdisc (Chinese), Wanfang Data (Chinese), PubMed, Embase, and Web of Science for relevant papers up to January 20, 2021. Read More

J Cardiovasc Med (Hagerstown) 2021 Jun 8. Epub 2021 Jun 8.

Department of Medical & Surgical Sciences, University of Foggia Ospedali Riuniti University Hospital, Foggia, Italy.

Spontaneous coronary artery dissection (SCAD) may be a cause of up to 1-4% of acute coronary syndrome overall, occurring mainly in young women, less than 50 years old, with no classical risk factor for CAD, especially during the postpartum period or associated with inflammatory disease. The clinical presentation varies from no symptoms to typical angina and sudden cardiac death. Multivessel coronary artery dissection is a very uncommon condition. Read More

Hypertension 2021 07 9;78(1):165-173. Epub 2021 Jun 9.

From the Department of Clinical Epidemiology, Biostatistics and Bioinformatics (S.S., S.-J.P.-S.), Amsterdam UMC, Academic Medical Center Amsterdam, the Netherlands.

[Figure: see text]. Read More

JMIR Mhealth Uhealth 2021 Jun 9;9(6):e24952. Epub 2021 Jun 9.

National Institute for Health Innovation, University of Auckland, Auckland, New Zealand.

Background: Mobile health technologies have the potential to improve the reach and delivery of interventions for promoting long-term secondary prevention of coronary heart disease.

Objective: This study aims to determine the effectiveness of an SMS text messaging intervention (Text4HeartII) for improving adherence to medication and lifestyle changes over and above usual care in people with coronary heart disease at 24 and 52 weeks.

Methods: A two-arm, parallel, randomized controlled trial was conducted in New Zealand. Read More

Turk Kardiyol Dern Ars 2021 06;49(4):334-338

Department of Cardiology, Katip Çelebi University School of Medicine, İzmir, Turkey.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global coronavirus disease 2019 (COVID-19) pandemic. Although the virus predominantly causes respiratory system infection, recent reports have shown that it is also associated with many cardiovascular complications. It has been reported that COVID-19 may cause myocarditis, type 1 and 2 acute myocardial infarction, and thrombotic complications. Read More

Turk Kardiyol Dern Ars 2021 Jun;49(4):328-333

Department of Cardiology, Balıkesir University School of Medicine, Balıkesir, Turkey.

The occurrence of acute coronary syndrome (ACS) following a scorpion sting has been very rarely reported in literature, and most of the cases presented had a normal coronary angiogram. The possible pathogenetic mechanisms include imbalance in blood pressure and coronary spasm caused by a combination of sympathetic excitation with subsequent thrombosis of coronary vessels developed after the release of vasoactive, inflammatory, and thrombogenic substances contained in the scorpion venom. In this report, we present a case of a scorpion sting complicated by ACS, called Kounis syndrome (KS). Read More

Turk Kardiyol Dern Ars 2021 06;49(4):293-302

Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Objective: Acute ischemic cardiac events can complicate coronavirus disease 2019 (COVID-19). We report the in-hospital characteristics of patients with acute myocardial infarction and concomitant COVID-19.

Methods: This was a registry-based retrospective analysis of patients admitted with positive COVID-19 tests who suffered acute myocardial infarction either before or during hospitalization; from 1 March 2020 to 1 April 2020 in a tertiary cardiovascular center-Tehran Heart Center. Read More

Turk Kardiyol Dern Ars 2021 Jun;49(4):257-265

Department of Family Medicine, Gemerek State Hospital, Sivas, Turkey.

Objective: Distal transradial access (TRA) has been recently introduced as an alternative access site for coronary angiography (CAG). Both procedures can be performed in cardiology clinics by interventional cardiologists. Although distal TRA is considered to be more difficult as it requires artery puncture and experienced cardiologists, it seems to be more advantageous because of the limited risk of arterial occlusion. Read More

Expert Opin Drug Saf 2021 Jun 9. Epub 2021 Jun 9.

Department of Cardiology, St. Antonius Hospital, Nieuwegein, the Netherlands.

Introduction: Dual antiplatelet therapy (DAPT) is the standard of treatment for patients with acute coronary syndrome (ACS). This includes lifelong aspirin combined with a P2Y inhibitor for one year. The indication for one of the P2Y inhibitors (clopidogrel, prasugrel, ticagrelor) is dependent on the treatment strategy; whether the patients undergo coronary angiography or are treated medically only. Read More

EuroIntervention 2021 Jun 8. Epub 2021 Jun 8.

Department of Cardiology, Inselspital, Bern University Hospital, Bern, Switzerland.

Background: The identification of bleeding risk factors in patients undergoing percutaneous coronary intervention (PCI) is essential to inform subsequent management. Whether clinical presentation per se affects bleeding risk after PCI remains unclear.

Aims: We aimed to assess whether clinical presentation per se predisposes to bleeding in patients undergoing PCI and if the Academic Research Consortium (ARC)-high bleeding risk (HBR) criteria perform consistently among acute (ACS) and chronic (CCS) coronary syndrome patients. Read More

Turk Gogus Kalp Damar Cerrahisi Derg 2021 Apr 26;29(2):271-274. Epub 2021 Apr 26.

Department of Cardiology, Bahçeşehir University Medical Park Göztepe Hospital, Istanbul, Turkey.

Takotsubo cardiomyopathy (left ventricular apical balloon syndrome) is characterized by transient apical ballooning, leading to apical systolic dysfunction. This syndrome typically mimics acute coronary syndrome in terms of electrocardiographic changes and cardiac enzyme release. Although its exact pathophysiology is still unclear, it is thought to be due to stress related to the catecholaminergic discharge. Read More

Pak J Med Sci 2021 May-Jun;37(3):890-896

Prof. Jill Pell, MBChB, MD, FFPH. Institutes of Health & Wellbeing, University of Glasgow, United Kingdom.

Objectives: To determine the effectiveness of mobile health augmented cardiac rehabilitation (MCard) on health-related quality of life (HRQoL), clinical and behavioural outcomes in post-ACS.

Methods: A single-centre, single-blinded, two-arm randomised controlled trial is planned at Armed Forces Institute of Cardiology (AFIC), Pakistan. The duration was two years, that is from January 2019 till December 2020. Read More