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    The relationship between apnoea hypopnoea index and Gensini score in patients with acute myocardial infarction undergoing emergency primary percutaneous coronary intervention.
    J Thorac Dis 2017 Aug;9(8):2476-2483
    Department of Sleep Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
    Background: Sleep apnoea hypopnoea syndrome (SAHS) is characterised by repetitive nocturnal hypoxemia and has a high prevalence among patients with acute myocardial infarction (AMI). But there are few studies on patients with AMI undergoing emergency primary percutaneous coronary intervention (pPCI). In this study, we want to find the prevalence of SAHS among patients with AMI undergoing emergency pPCI and determine whether SAHS would worsen the condition among these people, and especially affect the damage degree of the coronary artery. Read More

    Derivation and Validation of Shock Index as a parameter for Predicting Long-term Prognosis in Patients with Acute Coronary Syndrome.
    Sci Rep 2017 Sep 20;7(1):11929. Epub 2017 Sep 20.
    Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, P.R. China.
    The objective of this study was to examine whether shock index (SI), defined by ratio of heart rate and systolic blood pressure, can predict long-term prognosis of acute coronary syndrome (ACS) in patients undergoing percutaneous coronary intervention (PCI) and to compare prognostic accuracy of SI with the Global Registry of Acute Coronary Events (GRACE) risk score. This study included individuals from 2 independent cohorts: derivation cohort (n = 2631) and validation cohort (n = 963). In the derivation cohort, we derived that higher admission SI was associated with a greater risk of long-term all-cause mortality [HR = 4. Read More

    Clinical Characteristics and Long-Term Outcomes of Rotational Atherectomy - J2T Multicenter Registry.
    Circ J 2017 Sep 21. Epub 2017 Sep 21.
    Department of Cardiovascular Medicine, Juntendo University School of Medicine.
    Background: Rotational atherectomy (RA) is an adjunct tool for the management of heavily calcified coronary lesions during percutaneous coronary intervention (PCI), but the long-term clinical outcomes of RA use remain unclear in this drug-eluting stent era.Methods and Results:This multi-center registry assessed the characteristics and outcomes of patients treated by RA for calcified coronary lesions between 2004 and 2015. Among 1,090 registered patients, mean age was 70±10 years and 815 (75%) were male. Read More

    Peritoneal Dialysis for the Treatment of Cardiorenal Syndrome Type 1: A Prospective Brazilian Study.
    Perit Dial Int 2017 Sep-Oct;37(5):578-583
    Botucatu School of Medicine - UNESP, Internal Medicine, Botucatu, Brazil.
    This study aimed to explore the role of high-volume peritoneal dialysis (HVPD) in cardiorenal syndrome (CRS) type 1 patients in relation to metabolic and fluid control and outcome. Sixty-four patients were treated by HVPD (prescribed Kt/V = 0.50/session), flexible catheter and cycler. Read More

    Noninvasive assessment of left ventricular end-diastolic pressure by deceleration time of early diastolic mitral annular velocity in patients with heart failure.
    Echocardiography 2017 Sep;34(9):1292-1298
    Department of Medicine, Wakayama Medical University, Wakayama, Japan.
    Objective: To examine the diagnostic ability of the deceleration time of early mitral annular velocity (e'DT) as determined by tissue Doppler velocity image, a method for assessing LV filling pressure.

    Backgrounds: Estimation of LV filling pressure by Doppler echocardiography requires a combination of various parameters. Therefore, there remains a need for a simple index in LV filling pressure estimation. Read More

    An Unusual Case of Recurrent Hypersensitivity Reaction Associated with Kounis-Like Acute Coronary Syndrome.
    Case Rep Cardiol 2017 27;2017:6421208. Epub 2017 Aug 27.
    Cardiology, John D. Dingell VA Medical Center, Wayne State University, Detroit, MI, USA.
    There have been multiple reports of allergic reactions associated with acute coronary syndromes. This has been classically described as Kounis syndrome. We present an unusual case of 70-year-old male with multiple prior hypersensitivity reactions and history of coronary artery bypass grafting who presented recurrent episode of severe angioedema and anaphylaxis. Read More

    Aortic Regurgitation in Acute Type-A Aortic Dissection: A Clinical Classification for the Perioperative Echocardiographer in the Era of the Functional Aortic Annulus.
    J Cardiothorac Vasc Anesth 2017 Jun 7. Epub 2017 Jun 7.
    Cardiovascular and Thoracic Section, Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address:
    The functional aortic annulus offers a clinical approach for the perioperative echocardiographer to classify the mechanisms of aortic regurgitation in acute type-A dissection. Comprehensive examination of the functional aortic annulus in this setting using transesophageal echocardiography can guide surgical therapy for the aortic root by considering the following important aspects: severity and mechanism of aortic regurgitation, extent of root dissection, and the pattern of coronary artery involvement. The final choice of surgical therapy also should take into account factors, such as patient presentation and surgical experience, to limit mortality and morbidity from this challenging acute aortic syndrome. Read More

    Coronary access following TAVI - Selective coronary engagement using balloon-assisted tracking of a guide catheter extension.
    Cardiovasc Revasc Med 2017 Jul 31. Epub 2017 Jul 31.
    Cardiology, The James Cook University Hospital, Middlesbrough, United Kingdom.
    performing percutaneous coronary intervention (PCI) following transcatheter aortic valve implantation (TAVI) will become more frequent with the increasing use of TAVI in lower surgical risk populations. The ideal management strategy for coronary artery disease (CAD) in the setting of TAVI is not well defined and CAD is often left untreated prior to TAVI. Engaging the coronary ostia through the TAVI side cells can be challenging; techniques for rapid coronary cannulation, especially in the acute setting, need to be developed. Read More

    Case fatality of acute coronary events is improving even among elderly patients; the FINAMI study 1995-2012.
    Ann Med 2017 Sep 20:1-29. Epub 2017 Sep 20.
    c National Institute for Health and Welfare (THL) , Helsinki , Finland.
    Aim: To examine trends in incidence and 28-day case fatality of myocardial infarction (MI) in persons aged 75-99 years in four areas of Finland.

    Methods And Results: FINAMI is a population-based MI register study, which during 1995-2012 recorded 30561 suspected acute coronary syndromes in persons aged ≥75 years. Of them, 16229 fulfilled the American Heart Association criteria for a definite, probable or possible MI or coronary death. Read More

    Impact of co-morbid burden on mortality in patients with coronary heart disease, heart failure, and cerebrovascular accident: a systematic review and meta-analysis.
    Eur Heart J Qual Care Clin Outcomes 2017 Jan;3(1):20-36
    Keele Cardiovascular Research Group, Institute for Science and Technology in Medicine, Guy Hilton Research Centre, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB, UK.
    Aims: We sought to investigate the prognostic impact of co-morbid burden as defined by the Charlson Co-morbidity Index (CCI) in patients with a range of prevalent cardiovascular diseases.

    Methods And Results: We searched MEDLINE and EMBASE to identify studies that evaluated the impact of CCI on mortality in patients with cardiovascular disease. A random-effects meta-analysis was undertaken to evaluate the impact of CCI on mortality in patients with coronary heart disease (CHD), heart failure (HF), and cerebrovascular accident (CVA). Read More

    The contribution of the composite of clinical process indicators as a measure of hospital performance in the management of acute coronary syndromes-insights from the CONCORDANCE registry.
    Eur Heart J Qual Care Clin Outcomes 2017 Jan;3(1):37-46
    Department of Cardiology, Queen Elizabeth Hospital, 28 Woodville Rd, Woodville South, SA 5011, Australia.
    Aims: Acute coronary syndrome (ACS) is a costly condition for health service provision yet variation in the delivery of care between hospitals persists. A composite measure of adherence with evidence-based clinical-process indicators (CPIs) could better inform hospital performance reporting and clinical outcomes in the management of ACS.

    Methods: Data on 7444 ACS patients from 39 Australian hospitals were used to derive a hospital-specific composite quality score by calculating mean adherence to 14 evidence-based CPIs. Read More

    Has invasive management for acute coronary syndromes become more 'risk-appropriate': pooled results of five Australian registries.
    Eur Heart J Qual Care Clin Outcomes 2017 Apr;3(2):133-140
    Department of Cardiology, Concord Repatriation Hospital, University of Sydney, Sydney, NSW, Australia.
    Background: Despite being recommended in acute coronary syndrome (ACS) guidelines, the use of invasive management within specific risk groups continues to be debated. This study examines the change in the use of invasive management in ACS by patient risk and the associated change in mortality within Australia over the last 17 years.

    Methods: Pooled cohorts derived from five ACS registries (ACACIA, CONCORDANCE, GRACE, Snapshot-ACS, and Predict) spanned from 1999 to 2015. Read More

    Competing Risks of Cardiovascular Versus Noncardiovascular Death During Long-Term Follow-Up After Acute Coronary Syndromes.
    J Am Heart Assoc 2017 Sep 18;6(9). Epub 2017 Sep 18.
    Duke Clinical Research Institute, Durham, NC.
    Background: Understanding the relative risk of cardiovascular versus noncardiovascular death is important for designing clinical trials. These risks may differ depending on patient age, sex, and type of acute coronary syndrome (ACS).

    Methods And Results: IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial) was a randomized controlled trial of simvastatin plus either ezetimibe or placebo following stabilized ACS. Read More

    High-Sensitivity Cardiac Troponin I as a Gatekeeper for Coronary Computed Tomography Angiography and Stress Testing in Patients with Acute Chest Pain.
    Clin Chem 2017 Sep 18. Epub 2017 Sep 18.
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
    Background: Most patients presenting to the emergency department (ED) with suspected acute coronary syndrome (ACS) undergo noninvasive cardiac testing with a low diagnostic yield. We determined whether a combination of high-sensitivity cardiac troponin I (hs-cTnI) and cardiovascular risk factors might improve selection of patients for cardiac testing.

    Methods: We included patients from the Rule Out Myocardial Infarction/Ischemia Using Computer Assisted Tomography (ROMICAT) I and II trials who presented to the ED with acute chest pain and were referred for cardiac testing. Read More

    Prognostic usefulness of an age-adapted equation for renal function assessment in older patients with acute coronary syndrome.
    Eur Heart J Acute Cardiovasc Care 2017 Sep 1:2048872617730040. Epub 2017 Sep 1.
    Cardiology Department, Hospital Álvaro-Cunqueiro, Spain.
    Background: Renal dysfunction negatively impacts survival in acute coronary syndrome patients. The Berlin Initiative Study creatinine-based (BIScrea) equation has recently been proposed for renal function assessment in older persons. However, up to now it is unknown if the superiority of the new BIScrea equation, with respect to the most recommended chronic kidney disease epidemiology collaboration creatinine-based (CKD-EPIcrea) formula, would translate into better risk prediction of adverse events in older patients with acute coronary syndrome. Read More

    Migraine and risk of stroke and acute coronary syndrome in two case-control studies in the Danish population.
    Clin Epidemiol 2017 31;9:439-449. Epub 2017 Aug 31.
    Research Center for Prevention and Health, Rigshospitalet - Glostrup, Copenhagen University, Glostrup, Denmark.
    Introduction: Migraine has consistently been associated with increased risk of ischemic stroke, while the evidence for a relation with other types of stroke or coronary outcomes is limited. We examined the association between migraine and stroke and acute coronary syndrome (ACS) subtypes and the influence of potential confounding factors.

    Methods: All first-time hospital contacts for stroke (n=155,216) or ACS (n=97,799) were identified in Danish National Patient Registers and matched with 2 control groups of the background population. Read More

    Validation of the RETRIEVE (REverse TRIage EVEnts) Criteria for Same Day Return of Non-ST Elevation Acute Coronary Syndrome Patients to Referring Non-PCI Centres.
    Heart Lung Circ 2017 Aug 19. Epub 2017 Aug 19.
    Department of Cardiology, Liverpool Hospital, Sydney, NSW, Australia; Department of Cardiology, Campbelltown Hospital, Sydney, NSW, Australia; The University of New South Wales, Sydney, NSW, Australia; Western Sydney University, Sydney, NSW, Australia. Electronic address:
    Background: There are continuing bed constraints in percutaneous coronary intervention centres (PCI) so efficient patient triage from referral hospitals is pivotal. To evaluate a strategy of PCI centre (PCIC) bed-sparing we examined return of patients to referral hospitals screened by the RETRIEVE (REverse TRIage EVEnts) criteria and validated its use as a tool for screening suitability for same day transfer of non-ST-elevation acute coronary syndrome (NSTEACS) patients post PCI to their referring non-PCI centre (NPCIC).

    Methods: From May 2008 to May 2011, 433 NSTEACS patients were prospectively screened for suitability for same day transfer back to the referring hospital at the completion of PCI. Read More

    WITHDRAWN: Relation of Mean Platelet Volume-to-Lymphocyte Ratio and Contrast-Induced Acute Kidney Injury in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.
    Am J Cardiol 2017 Aug 8. Epub 2017 Aug 8.
    Ankara Education and Research Hospital, Department of Cardiology, Ankara, Turkey.
    This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www. Read More

    Coronary CT angiography features of ruptured and high-risk atherosclerotic plaques: Correlation with intra-vascular ultrasound.
    J Cardiovasc Comput Tomogr 2017 Sep 5. Epub 2017 Sep 5.
    Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
    Background: Features of ruptured and high-risk plaque have been described on coronary computed tomography angiography (coronary CTA), but not systematically assessed against intravascular ultrasound (IVUS). We examined the ability of coronary CTA to identify IVUS defined ruptured plaque and Virtual Histology Intravascular Ultrasound (VH-IVUS) defined thin-cap fibroatheroma (TCFA).

    Methods: Sixty-three patients (32 with acute coronary syndrome and 31 with stable angina) underwent coronary CTA, IVUS and VH-IVUS. Read More

    Direct Oral Anticoagulant Use in Atypical Thrombosis-Related Conditions.
    Ann Pharmacother 2017 Sep 1:1060028017731850. Epub 2017 Sep 1.
    2 Qatar University, Doha, Qatar.
    Objective: To review the published literature for evidence of the efficacy and safety of direct oral anticoagulants (DOACs) when used in the management of atypical thrombosis-related conditions.

    Data Sources: A comprehensive MEDLINE database search (1948 to July 2017) and EMBASE search (1980 to July 2017) were conducted using the search terms direct oral anticoagulant in combination with acute coronary syndrome (ACS), antiphospholipid antibody syndrome (APLAS), and cancer-associated thrombosis (CAT).

    Study Selection And Data Extraction: The literature search was limited to studies that were conducted in humans and published in English. Read More

    In-hospital outcomes of acute myocardial infarction with cardiogenic shock caused by right coronary artery occlusion vs. left coronary artery occlusion.
    Cardiovasc Interv Ther 2017 Sep 16. Epub 2017 Sep 16.
    Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama, 330-8503, Japan.
    In-hospital outcomes of acute myocardial infarction (AMI) with cardiogenic shock (CS) were still not satisfactory even in the primary percutaneous coronary intervention (PCI) era. The aim of this study was to compare in-hospital outcomes of AMI with CS caused by right coronary artery (RCA) occlusion vs. left coronary artery (LCA) occlusion. Read More

    Effect of Early Pitavastatin Therapy on Coronary Fibrous-Cap Thickness Assessed by Optical Coherence Tomography in Patients With Acute Coronary Syndrome: The ESCORT Study.
    JACC Cardiovasc Imaging 2017 Sep 9. Epub 2017 Sep 9.
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
    Objectives: The aim of the present study was to assess the effect of early statin therapy on fibrous-cap thickness in coronary plaques of patients with acute coronary syndrome (ACS) by using optical coherence tomography.

    Background: Statins can contribute to the stabilization of coronary plaques.

    Methods: This is a prospective, randomized, active-controlled, single-center study. Read More

    Role of Low Endothelial Shear Stress and Plaque Characteristics in the Prediction of Nonculprit Major Adverse Cardiac Events: The PROSPECT Study.
    JACC Cardiovasc Imaging 2017 Sep 15. Epub 2017 Sep 15.
    New York Presbyterian Hospital, Columbia University Medical Center, and the Cardiovascular Research Foundation, New York, New York.
    Objectives: This study sought to determine whether low endothelial shear stress (ESS) adds independent prognostication for future major adverse cardiac events (MACE) in coronary lesions in patients with high-risk acute coronary syndrome (ACS) from the United States and Europe.

    Background: Low ESS is a proinflammatory, proatherogenic stimulus associated with coronary plaque development, progression, and destabilization in human-like animal models and in humans. Previous natural history studies including baseline ESS characterization investigated low-risk patients. Read More

    Epidemiology, pathogenesis, and management of takotsubo syndrome.
    Clin Auton Res 2017 Sep 15. Epub 2017 Sep 15.
    Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Sjukhusbacken 10, 118 83, Stockholm, Sweden.
    Takotsubo syndrome is a recently recognized acute cardiac disease entity with a clinical presentation resembling that of an acute coronary syndrome. The typical takotsubo syndrome patient has a unique circumferential left (bi-) ventricular contraction abnormality profile that extends beyond a coronary artery supply territory and appears to follow the anatomical cardiac sympathetic innervation. The syndrome predominantly affects postmenopausal women and is often preceded by emotional or physical stress. Read More

    White Blood Cell Count and Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention in the Contemporary Era: Insights From the PARIS Study (Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients Registry).
    Circ Cardiovasc Interv 2017 Sep;10(9)
    From the Department of Medicine (Cardiology), New York Harbor Health Care System, Manhattan VA Hospital (B.S.); Department of Medicine (Cardiology), New York University School of Medicine (B.S.); Department of Medicine (Cardiology), Icahn School of Medicine at Mount Sinai, New York, NY (U.B., A.S.K., G.D., M.B.A., S.S., R.M.); Medical Statistics, London School of Hygiene and Tropical Medicine, United Kingdom (S.J.P., C.A.); Department of Medicine (Cardiology), Duke University School of Medicine, Durham, NC (M.W.K.); Department of Medicine (Cardiology), Harvard Medical School, Cambridge, MA (C.M.G.); Department of Medicine (Cardiology), Hôpital Bichat-Claude Bernard, Paris, France (P.G.S.); Department of Medicine (Cardiology), Columbia University Medical Center, New York, NY (G.W.); Department of Medicine (Cardiology), HELIOS Amper-Klinikum Dachau, Germany (B.W.); Department of Medicine (Cardiology), Cedars-Sinai Heart Institute, Los Angeles, CA (T.D.H.); Department of Medicine (Cardiology), Minneapolis Heart Institute Foundation, University of Minnesota (T.D.H.); Department of Medicine (Cardiology), Moses Cone Heart and Vascular Center, LeBauer Cardiovascular Research Foundation, Greensboro, NC (T.S.); Department of Medicine (Cardiology), St Luke's Mid America Heart Institute, University of Missouri-Kansas City (D.J.C.); Department of Medicine (Cardiology), Onassis Cardiac Surgery Center, Athens, Greece (I.I.); Department of Medicine (Cardiology), San Raffaele Hospital, Milan, Italy (A. Chieffo, A. Colombo); and Department of Medicine (Cardiology), University of Kentucky, Lexington (D.J.M.).
    Background: Elevated white blood cell (WBC) count is associated with increased major adverse cardiovascular events (MACE) in the setting of acute coronary syndrome. The aim of this study was to evaluate whether similar associations persist in an all-comers population of patients undergoing percutaneous coronary intervention in the contemporary era.

    Methods And Results: In the multicenter, prospective, observational PARIS study (Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients Registry), 4222 patients who underwent percutaneous coronary intervention in the United States and Europe between July 1, 2009, and December 2, 2010, were evaluated. Read More

    Impact of nonfasting triglycerides/high-density lipoprotein cholesterol ratio on secondary prevention in patients treated with statins.
    J Cardiol 2017 Sep 12. Epub 2017 Sep 12.
    Cardiovascular Center, KKR Takamatsu Hospital, Takamatsu, Japan.
    Background: Some studies have demonstrated that low-density lipoprotein cholesterol (LDL-C) lowering therapy is one of the most important strategies to prevent coronary artery disease. Also, serum triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) are recognized as independent risk factors of cardiovascular diseases. The aim of this study was to investigate whether the nonfasting TG/HDL-C ratio could affect the incidence of cardiovascular events after percutaneous coronary intervention (PCI) even in patients treated with statins. Read More

    Effect of Body Mass Index on Clinical Events After Acute Coronary Syndromes.
    Am J Cardiol 2017 Jul 29. Epub 2017 Jul 29.
    The Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Canada.
    The association between body mass index (BMI) and major clinical events after acute coronary syndrome (ACS) remains controversial. We investigated the impact of BMI on major clinical events after ACS in a large individual patient data meta-analysis. Data on 81,553 patients from 45 different countries with ACS enrolled in 8 large randomized clinical trials were included, followed up for a median of 171 days. Read More

    Emergency Neurological Life Support: Resuscitation Following Cardiac Arrest.
    Neurocrit Care 2017 Sep 14. Epub 2017 Sep 14.
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
    Cardiac arrest is the most common cause of death in North America. An organized bundle of neurocritical care interventions can improve chances of survival and neurological recovery in patients who are successfully resuscitated from cardiac arrest. Therefore, resuscitation following cardiac arrest was chosen as an Emergency Neurological Life Support protocol. Read More

    Everolimus-eluting bioresorbable vascular scaffold in daily clinical practice: A single-centre experience.
    Neth Heart J 2017 Sep 14. Epub 2017 Sep 14.
    Isala Hartcentrum, Zwolle, The Netherlands.
    Background: Recent evidence has raised concerns regarding the safety of the everolimus-eluting bioresorbable vascular scaffold (E-BVS) (Absorb, Abbott Vascular, Santa Clara, CA, USA). Following these data, the use of this device has diminished in the Netherlands; however, daily practice data are limited. Therefore we studied the incidence of safety and efficacy outcomes with this device in daily clinical practice in a single large tertiary centre in the Netherlands. Read More

    Risk Stratification Using the CHA2DS2-VASc Score in Takotsubo Syndrome: Data From the Takotsubo Italian Network.
    J Am Heart Assoc 2017 Sep 14;6(9). Epub 2017 Sep 14.
    Cardiovascular and Thoracic Department, Careggi University Hospital, Florence, Italy.
    Background: The CHA2DS2-VASc score predicts stroke in patients with atrial fibrillation and has been reported to have a prognostic role even in acute coronary syndrome patients. The Takotsubo syndrome is a condition that mimics acute coronary syndrome and may present several complications including stroke. We sought to assess the ability of CHA2DS2-VASc score to predict adverse events in Takotsubo syndrome patients. Read More

    Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.
    N Engl J Med 2017 Sep 14. Epub 2017 Sep 14.
    From the Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford (R.R.H., M.A.B.), and the International Centre for Circulatory Health, Imperial College London, London (N.P.) - both in the United Kingdom; Duke Clinical Research Institute, Duke University School of Medicine, Durham (R.J.M., V.P.T., Y.L., N.J.P., A.F.H.), and the Division of Endocrinology, University of North Carolina School of Medicine, Chapel Hill (J.B.B.) - both in North Carolina; the Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong (J.C.C.); AstraZeneca Research and Development, Gaithersburg, MD (J.C., S.M.G., N.I., P.Ö.); Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO) Research Center, Florence, Italy (A.P.M.); the Department of Cardiology, University of Texas Southwestern Medical Center, Dallas (S.P.M.); the India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, Chennai, India (A.R.); and the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital and University of Toronto, Toronto (B.Z.).
    Background The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown. Methods We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. Read More

    Gelatinases and physical exercise: A systematic review of evidence from human studies.
    Medicine (Baltimore) 2017 Sep;96(37):e8072
    aDipartimento di Scienze Psicologiche, Pedagogiche e della Formazione bDipartimento Biomedico di Medicina Interna e Specialistica Università degli Studi di Palermo, Palermo, Italy.
    Background: Matrix metalloproteinases (MMPs), particularly gelatinase A (MMP-2) and gelatinase B (MMP-9), as well as their tissue inhibitors (TIMP-1 and TIMP-2), are involved in the development of skeletal muscle tissue, in the repair process after muscle injury and in the adaptive modifications induced by physical exercise in skeletal muscle. This paper aims at reviewing results from human studies that investigated the role of gelatinases and their inhibitors in skeletal muscle response to acute physical exercise or training.

    Methods: Electronic databases PubMed/MEDLINE, Scopus and Web of Science were searched for papers published between January 2000 and February 2017. Read More

    Ticagrelor-induced life-threatening bleeding via the cyclosporine-mediated drug interaction: A case report.
    Medicine (Baltimore) 2017 Sep;96(37):e8065
    aDepartment of Pharmacy bDepartment of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
    Rationale: Ticagrelor has become one of the first-line antiplatelet agents in acute coronary syndrome (ACS) patients recommend by the guideline due to its more potent and predictable antiplatelet effect. However, bleeding is still a severe drug adverse reaction of ticagrelor therapy. We report a first case on ticagrelor-induced life-threatening bleeding via the cyclosporine-mediated drug interaction. Read More

    Clinical Manifestations of Kawasaki Disease Shock Syndrome.
    Clin Pediatr (Phila) 2017 Sep 1:9922817729483. Epub 2017 Sep 1.
    1 Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
    A case-control study was performed to ascertain clinical features of children who had been diagnosed as Kawasaki disease shock syndrome (KDSS), a severe condition related to Kawasaki disease (KD). Hospitalized patients were selected in Nanjing Children's Hospital. Demographic characteristics, clinical presentation, laboratory data, cardiovascular findings, and therapies were analyzed. Read More

    The Effect of Interactive Text Message Follow-up on Health Promoting Lifestyle of Patients with Acute Coronary Syndrome.
    Iran J Nurs Midwifery Res 2017 Jul-Aug;22(4):287-293
    Associated Professor, Cardiology Department Faculty of Medicin, Isfahan University of Medical Science, Isfahan, Iran.
    Background: Lifestyle modification is an essential factor in the promotion of health in patients with acute coronary syndrome (ACS). One of the interventions to promote lifestyle is interactive follow-up, which, according to the traditional methods, requires spending significant amount of time and cost. Therefore, this study aimed to determine the effectiveness of interactive text message follow-up on health promoting lifestyle of patients with ACS. Read More

    The association between apelin gene polymorphism and coronary artery disease in young patients with acute obstructive coronary syndrome.
    Turk Kardiyol Dern Ars 2017 Sep;45(6):520-526
    Department of Emergency Medicine, Bitlis State Hospital, Bitlis, Turkey.
    Objective: The purpose of this study was to evaluate the association between V103V, 6140AG, TGA-Stop-TAA Stop, and 6016CA polymorphisms of the apelin (APLN) gene detected for the first time among young patients with acute coronary syndrome (ACS) and coronary artery disease (CAD).

    Methods: This was a prospective cross-sectional study. The study population was divided into 2 groups. Read More

    Assessment of the association between the personality traits of young patients with acute coronary syndrome and the severity of coronary artery disease.
    Turk Kardiyol Dern Ars 2017 Sep;45(6):514-519
    Department of Cardiology, Antalya Training and Research Hospital, Antalya, Turkey.
    Objective: The role of psychosocial risk factors is becoming increasingly important in the etiology of acute coronary syndrome (ACS). The purpose of this study was to assess an association between the personality types of young patients with ACS and the prevalence and severity of coronary artery disease (CAD).

    Methods: Patients younger than 45 years of age who presented with ACS and who underwent coronary angiography in the period from 2012 to 2016 were included in the study. Read More

    The role of specialized prevention clinics for the short term follow-up of acute coronary syndromes.
    Turk Kardiyol Dern Ars 2017 Sep;45(6):498-505
    Department of Cardiology, Nizip State Hospital, Gaziantep, Turkey.
    Objective: This study aimed to investigate the effect of specialized prevention clinics and standard clinics follow-ups on secondary protection after acute coronary syndrome (ACS) on cardiovascular risk factors.

    Methods: A total of 118 patients who received thrombolytic therapy after being diagnosed with ST-segment elevation myocardial infarction were followed up for 6 months. After ACS, patients in a specialized prevention clinic (Group 1) (n=67) and those in a standard clinic (Group 2) (n=51) were compared in terms of the change in their lifestyle, management of risk factors, and drug compliance. Read More

    Expression of a nitric oxide synthesizing protein in arterial endothelial cells in response to different anti-anginal agents used in acute coronary syndromes.
    Protein Pept Lett 2017 Sep 11. Epub 2017 Sep 11.
    CMT Lab, Dept. of Biochemistry, Vidyasagar University Medinipur. India.
    Organic "nitro" compounds such as nitroglycerine, isosorbate nitrate are useful in the control of chest pain in acute coronary syndrome. But the mechanism of it in pain regulation remains speculative. Here, increase of NO production was investigated by the possible regulation of constitutive nitric oxide synthase (cNOS) function from goat arterial endothelial cells. Read More

    A retrospective external validation study of the HEART score among patients presenting to the emergency department with chest pain.
    Intern Emerg Med 2017 Sep 11. Epub 2017 Sep 11.
    Department of Emergency Medicine, San Antonio Military Medical Center, San Antonio Uniformed Services Health Education Consortium, 3551 Roger Brooke Dr., Fort Sam Houston, San Antonio, TX, 78234, USA.
    Emergency physicians must be able to effectively prognosticate outcomes for patients presenting to the Emergency Department (ED) with chest pain. The HEART score offers a prognostication tool, but external validation studies are limited. We conducted an external retrospective validation study of the HEART score among ED patients presenting to our ED with chest pain from 1 January 2014 to 9 June 2014. Read More

    Are acute coronary syndromes an ideal scenario for bioresorbable vascular scaffold implantation?
    J Thorac Dis 2017 Aug;9(Suppl 9):S969-S978
    Laboratory of Invasive Cardiology, Santa Maria della Pietà Hospital, Nola, Napoli, Italy.
    Bioresorbable vascular scaffolds (BRS) represent the latest innovation in the field of interventional cardiology. BRS have recently been introduced in routine clinical practice and their use has progressively extended in everyday clinical practice. The BRS use appears theoretically attractive in patients presenting with acute coronary syndromes (ACS) as they are generally young with long life expectancy, thus possibly benefiting more of the so-called vascular reparative therapy. Read More

    Timing of Angiography and Outcomes in High-Risk Patients with Non-ST Segment Elevation Myocardial Infarction Managed Invasively: Insights from the TAO Trial.
    Circulation 2017 Sep 11. Epub 2017 Sep 11.
    Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France; Département Hospitalo-Universitaire FIRE, INSERM U-1148, Paris, France; FACT (French Alliance for Cardiovascular Clinical Trials), an F-CRIN network, INSERM U-1148, Paris; Universität Paris-Diderot, Sorbonne-Paris Cité, Paris, France; NHLI, Royal Brompton Hospital, Imperial College, London, United Kingdom
    Background -In patients with non ST-elevation myocardial infarction (NSTEMI) and Global Registry of Acute Coronary Events (GRACE) score >140, coronary angiography (CAG) is recommended by European and American guidelines within 24h. We sought to study the association of a "very early" (i.e. Read More

    Emergency medicine evaluation and management of the end stage renal disease patient.
    Am J Emerg Med 2017 Sep 5. Epub 2017 Sep 5.
    Joint Base Elmendorf Richardson Medical Center, Department of Emergency Medicine, 5955 Zeamer Ave, JBER, AK, 99506, United States.
    Background: End stage renal disease (ESRD) is increasing in the U.S., and these patients demonstrate greater all-cause mortality, cardiovascular events, and hospitalization rates when compared to those with normal renal function. Read More

    Effects of person-centred care after an event of acute coronary syndrome: Two-year follow-up of a randomised controlled trial.
    Int J Cardiol 2017 Sep 6. Epub 2017 Sep 6.
    Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Box 457, 405 30 Gothenburg, Sweden; Centre for Person-Centred Care (GPCC), University of Gothenburg, Gothenburg, Sweden.
    Aim: To assess the long-term effect of person-centred care (PCC) in patients with acute coronary syndrome (ACS).

    Method: Patients with ACS were randomly assigned to treatment as usual (control group) or an added PCC intervention for six months. The primary endpoint was a composite score of changes in general self-efficacy≥five units, return to work or to a prior activity level and re-hospitalisation or death. Read More

    Prevalence of Conventional Risk Factors and Evaluation of Baseline Indices Among Young and Elderly Patients with Coronary Artery Disease.
    J Clin Diagn Res 2017 Jul 1;11(7):OC34-OC39. Epub 2017 Jul 1.
    Student, Department of Medicine, Dow University of Health Sciences, Karachi, Sindh, Pakistan.
    Introduction: Coronary Artery Disease (CAD) is a leading cause of morbidity and mortality worldwide, manifesting in a variety of clinical spectrums such as an asymptomatic disease or acute coronary syndrome. It has become highly prevalent in Southeast Asia, including Pakistan. There has been little work done on the prevalence of traditional risk factors in different age groups and genders and there is a dire need to gauge the importance of baseline indices in CAD patients. Read More

    Primary percutaneous coronary intervention for inferior ST-segment elevation myocardial infarction in a patient supported by the HeartWare left ventricular assist device.
    Intern Med J 2017 Sep;47(9):1068-1071
    Department of Interventional Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia.
    A 63-year-old man with an ischaemic cardiomyopathy, supported by the HeartWare left ventricular assist device (LVAD), presented with ventricular tachycardia and inferior ST-elevation myocardial infarction (STEMI) with associated acute right ventricular (RV) dysfunction. He underwent primary percutaneous coronary intervention with balloon angioplasty and placement of three drug-eluting stents in the proximal-to-mid right coronary artery. Post-procedure, ventricular arrhythmias abated, RV systolic dysfunction resolved and RV size normalised. Read More

    Cardiac troponin and outcome in decompensated heart failure with preserved ejection fraction.
    Cardiovasc Diagn Ther 2017 Aug;7(4):359-366
    Department of cardiology, Newark Beth Israel Medical Center, Newark, New Jersey, USA.
    Background: Cardiac troponin (cTn) has been established as an effective prognostic marker in acute heart failure (HF) with predominantly reduced ejection fraction. However, it's prognostic value in heart failure with preserved ejection fraction (HFpEF) is unclear. The aim of this study is to describe the prognostic role of troponin I in patients hospitalized for HFpEF decompensation. Read More

    Ascending Aorta Endovascular Repair of a symptomatic penetrating atherosclerotic ulcer with a custom made endo-graft.
    Ann Vasc Surg 2017 Sep 7. Epub 2017 Sep 7.
    Cardiovascular and Thoracic surgery department, Evangelismos General Hospital of Athens, Greece.
    Background: Thoracic endovascular aortic repair (TEVAR) has become lately the procedure of choice in the treatment of most pathologies of descending thoracic aorta. Aortic arch aneurysms also came to be treated by TEVAR with various hybrid techniques or custom made scalloped/fenestrated stent-grafts. Zone 0; ascending TEVAR is more challenging than TEVAR of the descending thoracic aorta or aortic arch because of the more complex pathology, hemodynamics, and anatomy. Read More

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