33,357 results match your criteria Acute Coronary Syndrome


Colchicine in Acute Coronary Syndrome: A Systematic Review.

Ann Pharmacother 2020 Jul 13:1060028020942144. Epub 2020 Jul 13.

Durham Veterans Affairs Health Care System, Durham, NC, USA.

The purpose of this review is to evaluate the efficacy and safety of colchicine after acute coronary syndrome (ACS). English-language searches were made of MEDLINE and EMBASE from database inception through mid-June 2020. Randomized trials characterizing the effects of colchicine in ACS were considered. Read More

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http://dx.doi.org/10.1177/1060028020942144DOI Listing

Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis.

Aging (Albany NY) 2020 Jul 13;12. Epub 2020 Jul 13.

Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, China.

A systematic review and meta-analysis was conducted in an attempt to systematically collect and evaluate the associations of epidemiological, comorbidity factors with the severity and prognosis of coronavirus disease 2019 (COVID-19). The systematic review and meta-analysis was conducted according to the guidelines proposed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Sixty nine publications met our study criteria, and 61 studies with more than 10,000 COVID-19 cases were eligible for the quantitative synthesis. Read More

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http://dx.doi.org/10.18632/aging.103579DOI Listing

Typical variant of takotsubo cardiomyopathy in oncological patients. Two case reports and review of the literature.

Folia Med Cracov 2020 ;60(1):45-54

Department of Coronary Artery Disease and Heart Failure, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland.

Takotsubo cardiomyopathy (TCM) represents an acute systolic left ventricular dysfunction typically triggered by severe psychological or physical stress. Oncological patients due to emotional distress of the diagnosis, proinflammatory and prothrombotic nature of cancer and also physical stress often following complex anticancer therapies are at high-risk of TCM. Moreover, there are also few reports of TCM associated with oncological treatment, mostly chemotherapy. Read More

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January 2020

Clinical Presentation and Outcome of Patients with Spontaneous Coronary Artery Dissection Versus Atherosclerotic Coronary Plaque Dissection.

Crit Pathw Cardiol 2020 Jul 9. Epub 2020 Jul 9.

Department of Cardiovascular Medicine, Baystate Medical Center, Tufts University School of Medicine, Springfield, Massachusetts.

Background: Atherosclerotic coronary plaque dissection (ACPD) is one cause of acute coronary syndrome caused by underlying atherosclerosis. Spontaneous coronary artery dissection (SCAD) occurs outside the setting of atherosclerosis among young women and individuals with few or no conventional atherosclerotic risk factors, and has emerged as an important cause of acute coronary syndrome, and sudden death. A comparison between ACPD and SCAD has not been previously addressed in the literature. Read More

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http://dx.doi.org/10.1097/HPC.0000000000000233DOI Listing

Prevalence of a postoperative troponin leak in patients with cardiac risk factors undergoing knee and hip arthroplasty in a South African population.

S Afr Med J 2020 Mar 30;110(4):320-326. Epub 2020 Mar 30.

Division of Orthopaedic Surgery, Department of Surgical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.

Background: Patients undergoing arthroplasty may have comorbidities that put them at risk of myocardial injury after non-cardiac surgery (MINS). MINS, a new clinical concept that has a different pathophysiology from conventional myocardial infarction, is related to a supply-demand mismatch ischaemia in the perioperative setting. MINS is often a silent event, and the diagnosis relies on cardiac biomarker testing such as troponin T. Read More

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http://dx.doi.org/10.7196/SAMJ.2020.v110i4.14133DOI Listing

Early changes in NT-proBNP levels predict new-onset heart failure in patients with STEMI.

Minerva Cardioangiol 2020 Jul 10. Epub 2020 Jul 10.

Division of Cardiology, Department of Internal Medicine, Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA -

Background: Previous studies suggested that N-terminal pro-Brain natriuretic peptide (NT- proBNP) level is a powerful independent predictor of death or heart failure (HF) when measured at admission in patients with chest pain or acute coronary syndrome. Little is known about the role of NT-proBNP level measured during a hospitalization for ST segment elevation myocardial infarction (STEMI) in predicting clinical outcomes. We evaluated the optimal NT-proBNP timing (admission, 72 hours, or delta [Δ] NT-proBNP [72 hours minus admission]) to predict 1-year new-onset HF in STEMI patients. Read More

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http://dx.doi.org/10.23736/S0026-4725.20.05303-7DOI Listing

Fewer gastrointestinal bleeds with ticagrelor and prasugrel compared with clopidogrel in patients with acute coronary syndrome following percutaneous coronary intervention.

Aliment Pharmacol Ther 2020 Jul 13. Epub 2020 Jul 13.

Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Rochester, MN, USA.

Background: Gastrointestinal bleeding (GIB) frequently occurs following percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) with the prescription of P2Y inhibiting antiplatelet agents. Compared with clopidogrel, the newer P2Y inhibitors lower major adverse cardiac events with similar or possibly higher major bleeding events. The comparative GIB rates of these medications remains poorly understood. Read More

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http://dx.doi.org/10.1111/apt.15790DOI Listing

Expecting the unexpected: Echo laboratory preparedness in the time of COVID-19.

Echocardiography 2020 Jul 13. Epub 2020 Jul 13.

Rush University Medical Center, Chicago, Illinois, USA.

COVID-19 poses a unique set of challenges to the healthcare system due to its rapid spread, intensive resource utilization, and relatively high morbidity and mortality. Healthcare workers are at especially high risk of exposure given the viruses spread through close contact. Reported cardiac complications of COVID-19 include myocarditis, acute coronary syndrome, cardiomyopathy, pericardial effusion, arrhythmia, and shock. Read More

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http://dx.doi.org/10.1111/echo.14763DOI Listing

Management of multivessel coronary artery disease in patients with non-ST-elevation myocardial infarction: a complex path to precision medicine.

Ther Adv Chronic Dis 2020 1;11:2040622320938527. Epub 2020 Jul 1.

Vascular Research Centre, Lifelong Health Theme, South Australian Health & Medical Research Institute, North Terrace, Adelaide, South Australia, 5000, Australia.

Recent analyses suggest the incidence of acute coronary syndrome is declining in high- and middle-income countries. Despite this, overall rates of non-ST-elevation myocardial infarction (NSTEMI) continue to rise. Furthermore, NSTEMI is a greater contributor to mortality after hospital discharge than ST-elevation myocardial infarction (STEMI). Read More

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http://dx.doi.org/10.1177/2040622320938527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331770PMC

Takotsubo syndrome.

Med Clin (Barc) 2020 Jul 9. Epub 2020 Jul 9.

Departamento de Cardiología, Hospital Clínico Universitario, Valladolid, España; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, España. Electronic address:

Takotsubo syndrome is an acute cardiomyopathy that mimics acute coronary syndrome and is characterized by acute heart failure with reversible ventricular motion abnormalities, in the absence of justifying coronary artery disease. This document offers an exhaustive review of various proposed hypotheses that attempt to explain the pathophysiology of this disease and provides an updated review of the different classifications that have emerged in recent years. In addition, we describe the main clinical characteristics of these patients, the diagnostic tests that must be performed and the most appropriate treatment. Read More

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http://dx.doi.org/10.1016/j.medcli.2020.04.023DOI Listing

Acromegaly-Induced Cardiomyopathy Masquerading as an Acute Coronary Syndrome.

Am J Med 2020 Jul 9. Epub 2020 Jul 9.

Department of Medicine, University of Florida, Gainesville, Florida; Division of Cardiology, University of Florida, Gainesville, Florida. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2020.05.045DOI Listing

Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study.

Lancet Child Adolesc Health 2020 Jul 9. Epub 2020 Jul 9.

Paediatric Intensive Care Unit, St Mary's Hospital, London, UK; Children's Acute Transport Service, Great Ormond Street Hospital NHS Foundation Trust and NIHR Biomedical Research Centre, London, UK.

Background: In April, 2020, clinicians in the UK observed a cluster of children with unexplained inflammation requiring admission to paediatric intensive care units (PICUs). We aimed to describe the clinical characteristics, course, management, and outcomes of patients admitted to PICUs with this condition, which is now known as paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS).

Methods: We did a multicentre observational study of children (aged <18 years), admitted to PICUs in the UK between April 1 and May 10, 2020, fulfilling the case definition of PIMS-TS published by the Royal College of Paediatrics and Child Health. Read More

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http://dx.doi.org/10.1016/S2352-4642(20)30215-7DOI Listing

Giant right coronary artery aneurysm in the setting of the acute coronary syndrome: A case report.

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Cardiac Surgery, AlMana General Hospital, AL Khobar, Saudi Arabia.

Giant right coronary artery (RCA) aneurysm is a rare coronary artery pathology. We describe a 45-year-old gentleman who presented with unstable angina of recent onset. Diagnostic workup including chest computed tomography angiography and left heart catheterization demonstrated three-vessel coronary artery disease with giant proximal RCA aneurysm. Read More

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http://dx.doi.org/10.1111/jocs.14717DOI Listing

Successful coronary artery bypass operation in a SARS-COV-2 infected patient with acute coronary syndrome.

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Division of Cardiothoracic Surgery, Westchester Medical Center and New York Medical College, Valhalla, New York.

The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is overwhelming healthcare resources and infrastructure worldwide. Earlier reports have demonstrated complicated postoperative courses and high fatality rates in patients undergoing emergent cardiothoracic surgery who were diagnosed postoperatively with COVID-19. These reports raise the possibility that active COVID-19 might precipitate a catastrophic pathophysiological response to infection in the postoperative period and lead to unfavorable surgical outcomes. Read More

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http://dx.doi.org/10.1111/jocs.14784DOI Listing

Association of serum regenerating islet-derived protein 3-beta and oncostatin-M levels with the risk of acute coronary syndrome in patients with type 2 diabetes mellitus - A pilot study.

Diabetes Metab Syndr 2020 Jun 18;14(5):1087-1092. Epub 2020 Jun 18.

Department of Emergency Medicine and Trauma, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 605 006, India.

Background And Aims: Regenerating islet-derived protein 3-beta (Reg3β) and oncostatin-M (OSM), an inducer of Reg3β, are important for the recruitment of macrophages, tissue repair and survival after myocardial infarction. The study was planned to elucidate the diagnostic utility of serum Reg3β and OSM levels for the acute coronary syndrome (ACS).

Methods: Forty-two type 2 diabetes mellitus (T2DM) patients with ACS as cases and forty-two T2DM patients as controls were recruited. Read More

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http://dx.doi.org/10.1016/j.dsx.2020.06.026DOI Listing

The Effect of Sleep Apnea on Cardiovascular Events in Different Acute Coronary Syndrome Phenotypes.

Am J Respir Crit Care Med 2020 Jul 10. Epub 2020 Jul 10.

Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain, Madrid, Spain.

Rationale Obstructive sleep apnea (OSA) is associated with increased cardiovascular disease (CVD) risk. Conversely, OSA has not been shown to increase recurrent cardiovascular events in acute coronary syndrome (ACS) patients. This lack of homogeneity could suggest that the deleterious effect of OSA and its contribution to CVD could depend on specific patient profiles. Read More

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http://dx.doi.org/10.1164/rccm.202004-1127OCDOI Listing

Recurrent asymptomatic Takotsubo syndrome after 20 years: are we looking at the tip of the iceberg only?

Future Cardiol 2020 Jul 10. Epub 2020 Jul 10.

Institute of Cardiology, Department of Cardiovascular & Thoracic Sciences, Catholic University of the Sacred Heart, Rome, Italy.

Takotsubo syndrome (TS) is an acute and reversible form of myocardial stunning preceded by emotional or physical stress, not explained by an obstruction of an epicardial coronary artery as in acute coronary syndrome. Over the last decades, TS is receiving growing attention, leading to an increase in awareness and diagnostic rate. Chest pain and dyspnea are the most common presenting symptoms; however, nonspecific presentations make the diagnosis challenging for clinicians. Read More

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http://dx.doi.org/10.2217/fca-2020-0043DOI Listing

Ethnic and Racial Disparities in Acute Myocardial Infarction.

Curr Cardiol Rep 2020 Jul 9;22(9):88. Epub 2020 Jul 9.

Cardiology Section, VA Eastern Colorado Health Care System, Aurora, CO, USA.

Purpose Of Review: Significant racial and ethnic healthcare disparities exist in the management and outcomes of patients with acute myocardial infarction (AMI). This review will highlight the recent studies focusing on disparities in AMI care and how practice patterns have changed over time, and discuss solutions and future directions to overcome disparities in AMI care.

Recent Findings: AMI continues to be a leading cause of morbidity and mortality in the USA. Read More

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http://dx.doi.org/10.1007/s11886-020-01351-9DOI Listing

Interleukin-7 and interleukin-15 drive CD4+CD28null T lymphocyte expansion and function in patients with acute coronary syndrome.

Cardiovasc Res 2020 Jul 9. Epub 2020 Jul 9.

Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, UK.

Aims: Inflammation has important roles in atherosclerosis. CD4+CD28null (CD28null) T cells are a specialised T lymphocyte subset that produce inflammatory cytokines and cytotoxic molecules. CD28null T cells expand preferentially in patients with acute coronary syndrome (ACS) rather than stable angina and are barely detectable in healthy subjects. Read More

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http://dx.doi.org/10.1093/cvr/cvaa202DOI Listing

Acute Coronary Syndrome Associated with Carfilzomib Treatment.

Indian J Hematol Blood Transfus 2020 Jul 13;36(3):592-593. Epub 2019 Dec 13.

Department of Cardiology, Başkent University Istanbul Hospital, Istanbul, Turkey.

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http://dx.doi.org/10.1007/s12288-019-01237-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326891PMC
July 2020
0.234 Impact Factor

Anxiety and clinical outcomes of patients with acute coronary syndrome: a meta-analysis.

BMJ Open 2020 Jul 9;10(7):e034135. Epub 2020 Jul 9.

Psychiatric Neuroimaging-Genetic and Comorbidity Laboratory (PNGC_Lab), Tianjin Mental Health Centre, Tianjin Anding Hospital, Tianjin, China

Objectives: Anxiety has been suggested to be associated with poor outcomes in patients with acute coronary syndrome (ACS). However, results of previous follow-up studies were inconsistent. The aim of this meta-analysis was to evaluate the association between anxiety and clinical outcomes in patients with ACS, and to investigate the potential role of depression underlying the above association. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034135DOI Listing
July 2020
2.063 Impact Factor

Acute Coronary Syndromes and Multivessel Disease: Completing the Evidence.

JACC Cardiovasc Interv 2020 Jul;13(13):1568-1570

Cardiology Division, Heart Center, Luzerner Kantonsspital, Lucerne, Switzerland.

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http://dx.doi.org/10.1016/j.jcin.2020.05.041DOI Listing

Long-Term Outcomes of Complete Revascularization With Percutaneous Coronary Intervention in Acute Coronary Syndromes.

JACC Cardiovasc Interv 2020 Jul;13(13):1557-1567

Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, Canada; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada; Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada.

Objectives: The aim of this study was to evaluate the long-term outcomes of patients with acute coronary syndromes (ACS) with multivessel disease undergoing percutaneous coronary intervention (PCI).

Background: Controversy exists regarding the benefit of multivessel PCI across the spectrum of ACS.

Methods: A total of 9,094 patients with ACS and multivessel disease (≥70% stenosis in 2 or more major epicardial vessels) undergoing PCI from the Alberta COAPT (Contemporary Acute Coronary Syndrome Patients Invasive Treatment Strategies) registry (April 1, 2007, to March 31, 2013) were reviewed. Read More

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http://dx.doi.org/10.1016/j.jcin.2020.04.034DOI Listing

Post-Discharge Bleeding and Mortality Following Acute Coronary Syndromes With or Without PCI.

J Am Coll Cardiol 2020 Jul;76(2):162-171

Duke Clinical Research Institute, Durham, North Carolina; Division of Cardiology, Duke University School of Medicine, Durham, North Carolina. Electronic address:

Background: The long-term prognostic impact of post-discharge bleeding in the unique population of patients with acute coronary syndrome (ACS) treated without percutaneous coronary intervention (PCI) remains unexplored.

Objectives: The aim of this study was to assess the association between post-discharge bleeding and subsequent mortality after ACS according to index strategy (PCI or no PCI) and to contrast with the association between post-discharge myocardial infarction (MI) and subsequent mortality.

Methods: In a harmonized dataset of 4 multicenter randomized trials (APPRAISE-2 [Apixaban for Prevention of Acute Ischemic Events-2], PLATO [Study of Platelet Inhibition and Patient Outcomes], TRACER [Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome], and TRILOGY ACS [Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes]), the association between post-discharge noncoronary artery bypass graft-related GUSTO (Global Use of Strategies to Open Occluded Coronary Arteries) moderate, severe, or life-threatening bleeding (landmark 7 days post-ACS) and subsequent all-cause mortality was evaluated in a time-updated Cox proportional hazards analysis. Read More

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http://dx.doi.org/10.1016/j.jacc.2020.05.031DOI Listing

Evaluating Mortality Rate and Associated Parameters in Patients with Acute Coronary Syndrome.

Cardiovasc Hematol Disord Drug Targets 2020 Jul 9. Epub 2020 Jul 9.

Student of Research committee, Tehran University of Medical Sciences, Tehran. Iran.

Background: Acute coronary syndrome (ACS) is one of the leading causes of mortality worldwide and is characterized by unstable angina or acute myocardial infarction. The aim of this study is to evaluate the clinical characteristics of patients who died of ACS.

Methods: In this cross-sectional study, 1000 patients presenting ACS were included. Read More

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http://dx.doi.org/10.2174/1871529X20666200709130533DOI Listing

Optimal antiplatelet strategy in Asian patients presenting with acute coronary syndrome.

Int J Cardiol 2020 Jul 6. Epub 2020 Jul 6.

Department of Cardiology, SMS Medical College, Jaipur, Rajasthan, India.

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http://dx.doi.org/10.1016/j.ijcard.2020.06.044DOI Listing

Dual anti-thrombotic treatment with direct anticoagulants improves clinical outcomes in patients with Atrial Fibrillation with ACS or undergoing PCI. A systematic review and meta-analysis.

PLoS One 2020 9;15(7):e0235511. Epub 2020 Jul 9.

Division of Cardiology, Department of Medical and Surgical Sciences, "Magna Graecia" University, Catanzaro, Italy.

Background: There is recent new evidence regarding the combined use of direct oral antiocoagulants and antiplatelet agents in patients with Atrial Fibrillation undergoing PCI.

Purpose: To compare the efficacy of dual antithrombotic treatment (DAT) including a direct oral anticoagulant (DOAC) and an antiplatelet agent versus triple antithrombotic treatment (TAT) with a vitamin K antagonist (VKA).

Data Sources: PubMed, SCOPUS and Google Scholar from through 09/09/2019; references of eligible studies; relevant scientific sessions abstracts and cardiology websites. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235511PLOS

Incidence of Stress Cardiomyopathy During the Coronavirus Disease 2019 Pandemic.

JAMA Netw Open 2020 07 1;3(7):e2014780. Epub 2020 Jul 1.

Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.

Importance: The coronavirus disease 2019 (COVID-19) pandemic has resulted in severe psychological, social, and economic stress in people's lives. It is not known whether the stress of the pandemic is associated with an increase in the incidence of stress cardiomyopathy.

Objective: To determine the incidence and outcomes of stress cardiomyopathy during the COVID-19 pandemic compared with before the pandemic. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.14780DOI Listing

The association of resting postoperative systolic, diastolic, and mean blood pressure and pulse pressure with short- and long-term mortality in patients with acute coronary syndrome undergoing primary PCI.

Minerva Cardioangiol 2020 Jul 8. Epub 2020 Jul 8.

Department of Cardiology, The Key Lab of Cardiovascular Disease of Wenzhou, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Background: Admission blood pressure was closely associated with adverse cardiac events in acute coronary syndrome (ACS) patients. However, data regarding comparison of resting postoperative systolic, diastolic, and mean blood pressure and pulse pressure with short- and long-term mortality in patients with acute coronary syndrome undergoing primary percutaneous coronary intervention (PCI) was still lacking.

Methods: 1,987 ACS patients undergoing primary PCI were analyzed, between January 2014 and October 2018. Read More

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http://dx.doi.org/10.23736/S0026-4725.20.05120-8DOI Listing

Prognostic Factors and Outcomes in Young Patients With Presented of Different Types Acute Coronary Syndrome.

Angiology 2020 Jul 9:3319720939444. Epub 2020 Jul 9.

Department of Cardiology, Sakarya University Education and Research Hospital, Sakarya, Turkey.

The prevalence of coronary artery disease is increasing in young adults. We evaluated the outcomes of different types of acute coronary syndrome in 917 patients undergoing coronary angiography aged ≤45 years. Male sex, smoking, dyslipidemia were the most important risk factors. Read More

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http://dx.doi.org/10.1177/0003319720939444DOI Listing

MINOCA: The caveat of absence of coronary obstruction in myocardial infarction.

Int J Cardiol Heart Vasc 2020 Aug 1;29:100572. Epub 2020 Jul 1.

Department of Cardiology, Maastricht University Medical Centre, Maastricht, the Netherlands.

Aims: Whether patients with MINOCA (myocardial infarction with non-obstructive coronary arteries) have better outcomes than patients with obstructive coronary artery disease remains contradictory. The current study focussed on the clinical profile and prognosis of MINOCA patients.

Methods And Results: We performed a retrospective analysis of patients with acute coronary syndrome (ACS) admitted to the Isala hospital in Zwolle, the Netherlands, between 2006 and 2014. Read More

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http://dx.doi.org/10.1016/j.ijcha.2020.100572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334364PMC

The effectiveness of mindfulness-based intervention on perceived stress and perception of disease in patients with acute coronary syndrome.

J Educ Health Promot 2020 28;9:130. Epub 2020 May 28.

Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Context: One of the most important issues in patients with coronary artery disease is their mental health indices such as perceived stress and perception of disease.

Aims: The aim of this study was to evaluate the effectiveness of mindfulness-based intervention on the perceived stress and disease perception of patients with acute coronary syndrome.

Materials And Methods: This is a clinical trial, two-group, and three-stage study on 76 patients with acute coronary syndrome who were randomly divided into intervention and control groups. Read More

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http://dx.doi.org/10.4103/jehp.jehp_660_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325788PMC

Underweight Predicts Greater Risk of Cardiac Mortality Post Acute Myocardial Infarction.

Int Heart J 2020 Jul 8. Epub 2020 Jul 8.

Clinical Atherosclerosis Research Laboratory, Division of Cardiology, University of Washington.

Increased body mass index (BMI) is a well-established risk factor for cardiovascular disease; however, patients with elevated BMI, in comparison to those with low BMI, seem to have better survival, a phenomenon reported as "obesity paradox," which remains controversial. We investigated the effect of BMI on cardiac mortality post acute myocardial infarction (AMI).In this analysis, 3562 AMI patients were included and classified into four groups based on BMI values. Read More

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http://dx.doi.org/10.1536/ihj.19-635DOI Listing
July 2020
1.127 Impact Factor

Impacts of geriatric nutritional risk index on prognosis of patients with non-ST-segment elevation acute coronary syndrome: Results from an observational cohort study in China.

Nutr Metab Cardiovasc Dis 2020 Jun 2. Epub 2020 Jun 2.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, Beijing, 100029, China. Electronic address:

Background And Aims: It is recognized that malnutrition increases risk of worse prognosis in patients with various diseases. The present study investigated if poor nutritional status predicts adverse outcomes in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) undergoing percutaneous coronary intervention (PCI).

Methods And Results: The study enrolled 2299 patients (mean age: 60. Read More

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http://dx.doi.org/10.1016/j.numecd.2020.05.016DOI Listing

Impacts of triglyceride-glucose index on prognosis of patients with type 2 diabetes mellitus and non-ST-segment elevation acute coronary syndrome: results from an observational cohort study in China.

Cardiovasc Diabetol 2020 Jul 8;19(1):108. Epub 2020 Jul 8.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, Beijing, 100029, China.

Background: The relationship between triglyceride-glucose index (TyG index) and the prevalence and prognosis of cardiovascular disease has been confirmed by former studies. However, it remains uncertain whether TyG index has a prognostic impact in patients with type 2 diabetes mellitus (T2DM) and non-ST-segment elevation acute coronary syndrome (NSTE-ACS) undergoing percutaneous coronary intervention (PCI).

Methods: The study retrospectively enrolled 798 patients (mean age: 60. Read More

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http://dx.doi.org/10.1186/s12933-020-01086-5DOI Listing

Sex-Specific Outcomes in Patients with Acute Coronary Syndrome.

J Clin Med 2020 Jul 6;9(7). Epub 2020 Jul 6.

Department of Cardiology, University Heart and Vascular Center Hamburg, 20246 Hamburg, Germany.

Sex differences in patients with acute coronary syndrome (ACS) are a matter of debate. We investigated sex-specific differences in the incidence, outcomes, and related interventions in patients diagnosed with ACS in Germany over the past decade. All ACS cases from 2005 to 2015 were collected. Read More

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http://dx.doi.org/10.3390/jcm9072124DOI Listing

Thiazide Use and Decreased Risk of Heart Failure in Nondiabetic Patients Receiving Intensive Blood Pressure Treatment.

Hypertension 2020 Aug 8;76(2):432-441. Epub 2020 Jul 8.

Department of Diabetes, Endocrinology, and Metabolism, Center Hospital, National Center for Global Health and Medicine, Tokyo, Japan (T.T., H.K.).

The SPRINT (Systolic Blood Pressure Intervention Trial) study reported that intensive blood pressure (BP) treatment with a systolic BP target of <120 mm Hg decreased the risks of cardiovascular events. However, it remains unknown whether specific medications can further improve cardiovascular outcome in patients receiving intensive BP treatment. This study examined whether thiazide use improves cardiovascular outcome in patients receiving intensive BP treatment. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.15154DOI Listing

Effect of C-Reactive Protein on Lipoprotein(a)-Associated Cardiovascular Risk in Optimally Treated Patients With High-Risk Vascular Disease: A Prespecified Secondary Analysis of the ACCELERATE Trial.

JAMA Cardiol 2020 Jul 8. Epub 2020 Jul 8.

MonashHeart, Department of Cardiology, Monash University, Clayton, Victoria, Australia.

Importance: Although lipoprotein(a) (Lp[a]) is a causal genetic risk factor for atherosclerotic cardiovascular disease, it remains unclear which patients with established atherosclerotic cardiovascular disease stand to benefit the most from Lp(a) lowering. Whether inflammation can modulate Lp(a)-associated cardiovascular (CV) risk during secondary prevention is unknown.

Objective: To examine whether Lp(a)-associated CV risk is modulated by systemic inflammation in optimally treated patients at high risk of CV disease. Read More

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http://dx.doi.org/10.1001/jamacardio.2020.2413DOI Listing

The optimal duration of dual antiplatelet therapy in East Asian patients undergoing percutaneous coronary intervention with drug-eluting stents: a meta-analysis of randomized trials.

Coron Artery Dis 2020 Jul 3. Epub 2020 Jul 3.

Department of Cardiology, Affiliated Hangzhou First People's Hospital, Nanjing Medical University, Shangcheng District, Hangzhou, Zhejiang Province, China.

Objective: The optimal duration of dual antiplatelet therapy (DAPT) is still controversial among East Asians. This meta-analysis was designed to evaluate the efficacy and safety of short-term (≤6 months) vs. long-term (≥12 months) DAPT in East Asians undergoing percutaneous coronary intervention (PCI) with drug-eluting stent (DES). Read More

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http://dx.doi.org/10.1097/MCA.0000000000000921DOI Listing

Coronavirus Disease 2019 and the Myocardium.

Arq Bras Cardiol 2020 06 3;114(6):1051-1057. Epub 2020 Jul 3.

C.T.E.B, UHG, Brazil.

Infection with the coronavirus known as COVID-19 has promoted growing interest on the part of cardiologists, emergency care specialists, intensive care specialists, and researchers, due to the study of myocardial involvement based on different clinical forms resulting from immunoinflammatory and neurohumoral demodulation.Myocardial involvement may be minimal and identifiable only by electrocardiographic changes, mainly increased cardiac troponins, or, on the other side of the spectrum, by forms of fulminant myocarditis and takotsubo syndrome.The description of probable acute myocarditis has been widely supported by the observation of increased troponin in association with dysfunction. Read More

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http://dx.doi.org/10.36660/abc.20200373DOI Listing

Peripheral artery disease in outpatients with a recent history of acute coronary syndrome or at high atherothrombotic risk.

Vascular 2020 Jul 8:1708538120938921. Epub 2020 Jul 8.

Department of Neurology, Hospital Civil de Guadalajara "Fray Antonio Alcalde", Guadalajara, Mexico.

Objectives: The frequency and implications of peripheral artery disease (PAD) in some risk groups are not entirely characterized in Latin America. We studied PAD prevalence, risk factors, and six-month outcomes in stable outpatients with a history of a recent acute coronary syndrome (ACS), or at high coronary risk.

Methods: We recruited 830 outpatients in 43 Mexican sites (median age: 64. Read More

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http://dx.doi.org/10.1177/1708538120938921DOI Listing

Long-Term Risk of Major Adverse Cardiovascular Events in Patients With Acute Coronary Syndrome: Prognostic Role of Complete Blood Cell Count.

Angiology 2020 Jul 8:3319720938619. Epub 2020 Jul 8.

Division of Cardiology, Ospedale Manzoni, Lecco, Italy.

Individual parameters of complete blood count (CBC) have been associated with worse outcome in patients with acute coronary syndrome (ACS). However, the prognostic role of CBC taken as a whole has never been evaluated for long-term incidence of major adverse cardiovascular events (MACEs). Patients were grouped according to their hematopoietic cells' inflammatory response at different time points during hospital stay. Read More

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http://dx.doi.org/10.1177/0003319720938619DOI Listing

Use of proteomics to identify biomarkers associated with chronic kidney disease and long-term outcomes in patients with myocardial infarction.

J Intern Med 2020 Jul 8. Epub 2020 Jul 8.

From the, Department of Clinical Sciences, Division of Cardiovascular Medicine, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.

Background: Patients with chronic kidney disease (CKD) have poor outcomes following myocardial infarction (MI). We performed an untargeted examination of 175 biomarkers to identify those with the strongest association with CKD and to examine the association of those biomarkers with long-term outcomes.

Methods: A total of 175 different biomarkers from MI patients enrolled in the Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies (SWEDEHEART) registry were analysed either by a multiple reaction monitoring mass spectrometry assay or by a multiplex assay (proximity extension assay). Read More

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http://dx.doi.org/10.1111/joim.13116DOI Listing

Applying the CHADS-VASc score to predict the risk of future acute coronary syndrome in patients receiving catheter ablation for atrial fibrillation.

Int J Cardiol Heart Vasc 2020 Aug 28;29:100567. Epub 2020 Jun 28.

Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Objective: It remains unknown whether catheter ablation for atrial fibrillation (AF) reduces future acute coronary syndrome (ACS) risk or whether the CHADS-VASc score has a role in predicting this risk. We aimed to compare very long-term risk of ACS between patients who received catheter ablation to AF or antiarrhythmic medications and controls without AF.

Methods: Propensity scores were calculated for each patient and used to assemble a cohort of 787 patients undergoing AF ablation in 2003-2012. Read More

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http://dx.doi.org/10.1016/j.ijcha.2020.100567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330062PMC

A case of very late stent thrombosis on the protruded struts at the left main coronary bifurcation.

J Cardiol Cases 2020 Jul 14;22(1):40-43. Epub 2020 May 14.

Department of Cardiology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.

A previous autopsy study has revealed that malapposed or protruded struts in the coronary bifurcation were a risk factor for very late stent thrombosis (VLST); however, a live clinical case has not yet been reported due to difficulty in observation at the VLST site. In this case, a 56-year-old male patient underwent a zotarolimus-eluting stent implantation in the proximal left anterior descending artery for acute myocardial infarction 3 years previously and had been treated with dual antiplatelet therapy. The patient experienced chest pain and suddenly collapsed due to acute coronary syndrome caused by a huge thrombus in the left main coronary bifurcation. Read More

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http://dx.doi.org/10.1016/j.jccase.2020.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326694PMC

Ostial left circumflex lesion with calcified nodule successfully treated with excimer laser coronary atherectomy and drug-coated balloon.

J Cardiol Cases 2020 Jul 7;22(1):32-35. Epub 2020 May 7.

Department of Cardiovascular Medicine, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.

Stenting for severely calcified lesions has a higher risk of stent restenosis or stent failure than stenting for lesions without calcification, and stenting for complex lesions including ostial or bifurcation lesions sometimes causes plaque shift which leads to side branch occlusion. A calcified nodule (CN) is considered one of the culprits for stable angina or acute coronary syndrome. However, the optimal strategy for this lesion is not well clarified. Read More

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http://dx.doi.org/10.1016/j.jccase.2020.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326664PMC

The Prevalence and Diagnostic Ratio of Familial Hypercholesterolemia (FH) and Proportion of Acute Coronary Syndrome in Japanese FH Patients in a Healthcare Record Database Study.

Cardiovasc Ther 2020 11;2020:5936748. Epub 2020 Jun 11.

Amgen K.K., Tokyo, Japan.

Background: Familial hypercholesterolemia (FH) is a genetic disorder characterized by high levels of low-density lipoprotein cholesterol (LDL-C). Because of underdiagnosis, acute coronary syndrome (ACS) is often the first clinical manifestation of FH. In Japan, there are few reports on the prevalence and diagnostic ratios of FH and the proportion of ACS among FH patients in clinical settings. Read More

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http://dx.doi.org/10.1155/2020/5936748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321519PMC

Platelet-to-lymphocyte ratio is a predictor of long-term mortality in patients with acute coronary syndrome.

Postepy Kardiol Interwencyjnej 2020 Jun 23;16(2):170-176. Epub 2020 Jun 23.

Department of Cardiology, School of Medicine, Dicle University, Diyarbakır, Turkey.

Introduction: Atherosclerosis is a chronic inflammatory process and inflammation is an important component of acute coronary syndrome (ACS). Platelet-to-lymphocyte ratio (PLR) is a useful parameter showing the degree of the inflammatory response.

Aim: To explore the association between PLR and long-term mortality in patients with ACS. Read More

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http://dx.doi.org/10.5114/aic.2020.95859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333190PMC