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    25374 results match your criteria Acute Coronary Syndrome

    1 OF 508

    Near-infrared spectroscopy-derived lipid core burden index predicts adverse cardiovascular outcome in patients with coronary artery disease during long-term follow-up.
    Eur Heart J 2017 May 20. Epub 2017 May 20.
    Department of Cardiology, Erasmus MC, Ba-585, 's Gravendijkwal 230, 3015CE Rotterdam, The Netherlands.
    Aims: Near-infrared spectroscopy (NIRS) is able to quantify cholesterol within coronary arteries by the lipid core burden index (LCBI). We studied the prognostic value of NIRS-derived LCBI in patients with coronary artery disease (CAD) for adverse cardiac outcome during long-term follow-up.

    Methods And Results: During 2009-2013, NIRS was performed in a non-culprit artery of 275 patients undergoing coronary angiography for acute coronary syndrome (ACS) or stable angina. Read More

    Clinical Implications of Electrocardiograms for Patients With Type A Acute Aortic Dissection.
    Circ J 2017 May 19. Epub 2017 May 19.
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine.
    Type A acute aortic dissection (AAD) is a serious cardiovascular emergency requiring urgent surgery. Timely accurate diagnosis is essential, but often challenging, because of the wide spectrum of clinical presentations. In patients with type A AAD, chest pain is the most common symptom; furthermore, ischemic ST-T changes such as ST-segment elevation or depression or negative T waves are frequently observed on presentation ECG. Read More

    Acute Kidney Injury After Radial or Femoral Access for Invasive Acute Coronary Syndrome Management: AKI-MATRIX.
    J Am Coll Cardiol 2017 May 11. Epub 2017 May 11.
    Swiss Cardiovascular Center Bern, Bern University Hospital, Bern, Switzerland. Electronic address:
    Background: It remains unclear whether radial access (RA), compared with femoral access (FA), mitigates the risk of acute kidney injury (AKI).

    Objectives: The authors assessed the incidence of AKI in patients with acute coronary syndrome (ACS) enrolled in the MATRIX-Access (Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of Angiox) trial.

    Methods: Among 8,404 patients, 194 (2. Read More

    Risk classification of highly sensitive troponin I predict presence of vulnerable plaque assessed by dual source coronary computed tomography angiography.
    Int J Cardiovasc Imaging 2017 May 20. Epub 2017 May 20.
    Department of Radiology, The First Affiliated Hospital of China Medical University, 155 Nanjing Bei St, Heping District, Shenyang, China.
    Patients presenting to the emergency department with acute chest pain, negative conventional troponin and electrocardiogram require serial testing to rule out acute coronary syndrome (ACS). We studied the association of highly sensitive troponin (hsTn) I with vulnerable plaque features as detected by coronary dual source computed tomography angiography (DSCTA) and determined whether hsTn I at the time of presentation combined with early DSCTA could improve classification of patients as high-risk or low risk for ACS. We included 220 patients with acute chest pain, negative electrocardiogram and conventional troponin who underwent DSCTA and had hsTn I measured at the time of presentation. Read More

    Depressive Symptoms and Perceptions of ED Care in Patients Evaluated for Acute Coronary Syndrome.
    J Emerg Nurs 2017 May 17. Epub 2017 May 17.
    New York, NY. Electronic address:
    Introduction: Posttraumatic stress disorder (PTSD) develops in 1 out of 8 survivors of acute coronary syndrome (ACS) events, and these persons have a doubling of risk for recurrent ACS and mortality. Overcrowding in the emergency department during ACS evaluation has been associated with increased risk for PTSD, and depressed patients have been found to be particularly vulnerable. Little is known about the mechanisms by which overcrowding increases PTSD risk in depressed patients. Read More

    Lutein exerts anti-inflammatory effects in patients with coronary artery disease.
    Atherosclerosis 2017 May 6;262:87-93. Epub 2017 May 6.
    Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, SE-581 85 Linköping, Sweden.
    Background And Aims: Many coronary artery disease (CAD) patients exhibit chronic low-grade inflammation. Carotenoids are anti-oxidants with potential anti-inflammatory properties. Here, we first assessed relationships between interleukin (IL)-6 and individual carotenoids in plasma from CAD patients. Read More

    No significant gender difference in hospitalizations for acute coronary syndrome in Switzerland over the time period of 2001 to 2010.
    Int J Cardiol 2017 May 13. Epub 2017 May 13.
    Gynecological Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, Inselspital, University of Bern, Switzerland.
    Background: Morbidity and mortality from cardiovascular diseases have decreased since the 1970s in most Western societies. However, it is unclear if this positive trend can also be found in younger women suffering from acute coronary syndrome (ACS).

    Methods: This is a prospective single center registry study including 11. Read More

    Acute coronary syndromes in the very elderly: Short term prognostic performance of the SYNTAX score.
    Int J Cardiol 2017 May 12. Epub 2017 May 12.
    Department of Cardiology, University Hospital Reims, Reims, France.
    Acute coronary syndromes (ACS) frequently occur in elderly subjects. The high mortality associated with ACS in this population justifies the identification of factors related to poor prognosis. We aimed to evaluate the short-term prognostic performance of the SYNTAX score in a population of patients aged 85years or more presenting ACS and undergoing coronary angiography. Read More

    Trastuzumab emtansine versus capecitabine plus lapatinib in patients with previously treated HER2-positive advanced breast cancer (EMILIA): a descriptive analysis of final overall survival results from a randomised, open-label, phase 3 trial.
    Lancet Oncol 2017 May 16. Epub 2017 May 16.
    San Raffaele Hospital, Milan, Italy.
    Background: The antibody-drug conjugate trastuzumab emtansine is indicated for the treatment of patients with HER2-positive metastatic breast cancer previously treated with trastuzumab and a taxane. Approval of this drug was based on progression-free survival and interim overall survival data from the phase 3 EMILIA study. In this report, we present a descriptive analysis of the final overall survival data from that trial. Read More

    Effectiveness of a Decision Aid in Potentially Vulnerable Patients: A Secondary Analysis of the Chest Pain Choice Multicenter Randomized Trial.
    Med Decis Making 2017 May 1:272989X17706363. Epub 2017 May 1.
    Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA (KLR, JEH).
    Background: We test the hypotheses that use of the Chest Pain Choice (CPC) decision aid (DA) would be similarly effective in potentially vulnerable subgroups but increase knowledge more in patients with higher education and trust in physicians more in patients from racial minority groups.

    Methods: This was a secondary analysis of a multicenter randomized trial in adults with chest pain potentially due to acute coronary syndrome. The trial compared an intervention group engaged in shared decision making (SDM) using CPC to a control group receiving usual care (UC). Read More

    Relationships of Inflammatory Factors and Risk Factors with Different Target Organ Damage in Essential Hypertension Patients.
    Chin Med J (Engl) 2017 Jun;130(11):1296-1302
    Postgraduate School of Shanxi Medical University, Taiyuan, Shanxi 030012, China.
    Background: Atherosclerosis (AS) is an inflammatory disease. Inflammation was considered to play a role in the whole process of AS. This study aimed to analyze the relationships of inflammatory factors and risk factors with different target organ damages (TOD) in essential hypertension (EH) patients and to explore its clinical significance. Read More

    Rivaroxaban - Metabolism, Pharmacologic Properties and Drug Interactions.
    Curr Drug Metab 2017 May 18. Epub 2017 May 18.
    Thrombotic Centre of Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine of Charles University,Prague. Czech Republic.
    Background: Rivaroxaban represents a selective direct inhibitor of activated coagulation factor X (FXa) having peroral bioavailability and prompt onset of action.

    Objective: The absorbtion of rivaroxaban is quick, reaching maximum plasma concentration 2-4 hours following its administration. Peroral bioavailability is high (80-100 %) and pharmacokinetic variability is considered to be moderate (coefficient of variation 30-40 %). Read More

    Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y12 signaling with MRS2395.
    Platelets 2017 May 19:1-12. Epub 2017 May 19.
    a Department of Biomedical Engineering, School of Medicine , Oregon Health & Science University , Portland , OR , USA.
    The release of ADP from platelet dense granules and its binding to platelet P2Y12 receptors is key to amplifying the initial hemostatic response and propagating thrombus formation. P2Y12 has thus emerged as a therapeutic target to safely and effectively prevent secondary thrombotic events in patients with acute coronary syndrome or a history of myocardial infarction. Pharmacological inhibition of P2Y12 receptors represents a useful approach to better understand the signaling mediated by these receptors and to elucidate the role of these receptors in a multitude of platelet hemostatic and thrombotic responses. Read More

    Thrombotic responses to coronary stents, bioresorbable scaffolds and the Kounis hypersensitivity-associated acute thrombotic syndrome.
    J Thorac Dis 2017 Apr;9(4):1155-1164
    Department of Cardiology, University of Patras Medical School, Patras, Rion, Achaia, Greece.
    Percutaneous transluminal coronary angioplasty with coronary stent implantation is a life-saving medical procedure that has become, nowadays, the most frequent performed therapeutic procedure in medicine. Plain balloon angioplasty, bare metal stents, first and second generation drug-eluting stents, bioresorbable and bioabsorbable scaffolds have offered diachronically a great advance against coronary artery disease and have enriched our medical armamentarium. Stented areas constitute vulnerable sites for endothelial damage, endothelial dysfunction, flow turbulence, hemorheologic changes, platelet dysfunction, coagulation changes and fibrinolytic disturbances. Read More

    Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography: A 4-Year Follow-Up Study.
    J Am Coll Cardiol 2017 May;69(20):2502-2513
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Division of Cardiology, Department of Internal Medicine, KyungHee University Hospital, Seoul, Republic of Korea. Electronic address:
    Background: Lipid-rich plaque (LRP) is thought to be a precursor to cardiac events. However, its clinical significance in coronary arteries has never been systematically investigated.

    Objectives: This study investigated the prevalence and clinical significance of LRP in the nonculprit region of the target vessel in patients undergoing percutaneous coronary intervention (PCI). Read More

    Are ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis associated with an increased risk of cardiovascular events? A prospective nationwide population-based cohort study.
    Arthritis Res Ther 2017 May 18;19(1):102. Epub 2017 May 18.
    Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Box 480, 405 30, Gothenburg, Sweden.
    Background: To investigate the risk of first-time acute coronary syndrome (ACS), stroke and venous thromboembolism (VTE) in patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA) and undifferentiated spondyloarthritis (uSpA), compared to each other and to the general population (GP).

    Methods: This is a prospective nationwide cohort study. Cohorts with AS (n = 6448), PsA (n = 16,063) and uSpA (n = 5190) patients and a GP (n = 266,435) cohort, were identified 2001-2009 in the Swedish National Patient and Population registers. Read More

    von Willebrand factor and its cleaving protease ADAMTS13 balance in coronary artery vessels: Lessons learned from thrombotic thrombocytopenic purpura. A narrative review.
    Thromb Res 2017 May 12;155:78-85. Epub 2017 May 12.
    Dipartimento di Scienze Della Salute, Università Degli Studi di Milano, Milan, Italy; Unità di Medicina 3, ASST Santi Paolo e Carlo, Milan, Italy.
    Background: Deficiency of the von Willebrand factor-cleaving protease ADAMTS13 is central to the pathophysiology of thrombotic thrombocytopenic purpura (TTP), a microangiopathic syndrome that presents as an acute medical emergency. In this review we will explore the evidence of a two-way relationship between TTP and ACS. Moreover, we will review the evidence emerged from epidemiological studies of an inverse relationship between the plasma levels of ADAMTS13 and the risk of ACS. Read More

    Integrated metabolomics and metallomics analyses in acute coronary syndrome patients.
    Metallomics 2017 May 18. Epub 2017 May 18.
    Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543. and NUS Environmental Research Institute, National University of Singapore, 5A Engineering Drive 1, T-Lab Building, Singapore 117411.
    Acute coronary syndrome (ACS) is the leading cause of morbidity and mortality. Accurate risk prediction in ACS patients is critically important for helping clinicians make therapeutic decisions, such as recommending a more aggressive intervention and intensive follow-up. However, risk stratification in ACS patients remains challenging, and the identification of novel predictors is necessary for improving the prognostic prediction in ACS patients. Read More

    Management of elderly patients with a non-ST-segment-elevation acute coronary syndrome.
    Neth Heart J 2017 May 17. Epub 2017 May 17.
    Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
    Elderly patients with an acute coronary syndrome are underrepresented in randomised controlled trials. Neither the European Society of Cardiology nor the American Heart Association/American College of Cardiology acute coronary syndrome guidelines provide specific recommendations for elderly patients. However, elderly patients are at higher thrombotic and bleeding risk compared with younger patients leading to difficulties in choosing the optimal treatment. Read More

    Late Presentation of Aortic Aneurysm and Dissection Following Cardiac Catheterization.
    Cardiol Res 2017 Apr 3;8(2):68-72. Epub 2017 May 3.
    Division of Cardiology, University of South Alabama, Mobile, AL, USA.
    We report a 63-year-old female with hypertension, hyperlipidemia, and prior pacemaker insertion for atrial fibrillation with symptomatic bradycardia, who was admitted with substernal chest pressure and diaphoresis. Her electrocardiogram revealed atrial fibrillation with demand ventricular pacing and her cardiac biomarkers were negative for acute coronary syndrome. Echocardiogram revealed normal left ventricular systolic function and normal aortic root diameter. Read More

    Direct Comparison of 2 Rule-Out Strategies for Acute Myocardial Infarction: 2-h Accelerated Diagnostic Protocol vs 2-h Algorithm.
    Clin Chem 2017 May 17. Epub 2017 May 17.
    Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, Basel, Switzerland;
    Background: We compared 2 high-sensitivity cardiac troponin (hs-cTn)-based 2-h strategies in patients presenting with suspected acute myocardial infarction (AMI) to the emergency department (ED): the 2-h accelerated diagnostic protocol (2h-ADP) combining hs-cTn, electrocardiogram, and a risk score, and the 2-h algorithm exclusively based on hs-cTn concentrations and their absolute changes.

    Methods: Analyses were performed in 2 independent diagnostic cohorts [European Advantageous Predictors of Acute Coronary Syndrome Evaluation (APACE) study, Australian-New Zealand 2-h Accelerated Diagnostic Protocol to Assess patients with chest Pain symptoms using contemporary Troponins as the only biomarker (ADAPT) study] employing hs-cTnT (Elecsys) and hs-cTnI (Architect). The final diagnosis was adjudicated by 2 independent cardiologists. Read More

    Temporal Biomarker Profiling Reveals Longitudinal Changes in Risk of Death or Myocardial Infarction in Non-ST-Segment Elevation Acute Coronary Syndrome.
    Clin Chem 2017 May 17. Epub 2017 May 17.
    The 3rd Medical Department, Cardiology and Intensive Care Medicine, Wilhelminenhospital and Sigmund Freud Private University, Medical School, Vienna, Austria.
    Background: There are conflicting data on whether changes in N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) concentrations between time points (delta NT-proBNP and hs-CRP) are associated with a change in prognosis.

    Methods: We measured NT-proBNP and hs-CRP at 3 time points in 1665 patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Cox proportional hazards was applied to the delta between temporal measurements to determine the continuous association with cardiovascular events. Read More

    Early Versus Delayed Invasive Strategies in High-Risk Non-ST Elevation Acute Coronary Syndrome Patients - A Systematic Literature Review and Meta-Analysis of Randomised Controlled Trials.
    Heart Lung Circ 2017 Apr 11. Epub 2017 Apr 11.
    Department of Cardiology, Mackay Base Hospital, Brisbane, QLD, Australia; Mackay Clinical School, School of Medicine and Dentistry, James Cook University, Mackay Campus, Brisbane, QLD, Australia.
    Rationale: It is unclear whether it is beneficial to perform angiography and/or percutaneous coronary intervention (PCI) as an early or delayed invasive strategy amongst high-risk non-ST elevation acute coronary syndrome (NSTEACS) patients.

    Objective: To determine whether an early invasive strategy could further reduce recurrent myocardial infarction (MI) and early mortality compared to a delayed invasive strategy.

    Methods And Results: We searched MEDLINE, CINAHL and SCOPUS and performed a meta-analysis of nine RCTs with a total of 5274 patients. Read More

    Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease.
    N Engl J Med 2017 05;376(20):1933-1942
    From the Cleveland Clinic Coordinating Center for Clinical Research (C5Research), Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland (A.M.L., V.M., E.M., K.W., D.M., S.E.N.); South Australian Heart and Medical Research Institute, University of Adelaide, Adelaide (S.J.N.), and School of Medical Sciences, University of New South Wales, Sydney (P.J.B.) - both in Australia; Eli Lilly, Indianapolis (J.S.R., G.R., B.V., G.W.); Washington Cardiovascular Associates, Medstar Research Institute, Washington, DC (H.B.B.); Centre for Cardiovascular Science, University of Edinburgh, Edinburgh (K.A.A.F.); Beth Israel Deaconess Medical Center, Boston (C.M.G.); Duke University Medical Center, Durham, NC (C.G.); Université Sorbonne Paris 6, ACTION Study Group, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Institut de Cardiologie, Paris (G.M.); Penn Heart and Vascular Center, Philadelphia (D.R.); Columbia University, New York (A.R.T.), and Saratoga Cardiology Associates, Saratoga Springs (D.K.) - both in New York; St. Michael's Hospital, Toronto (S.G.), Recherche Médicale Saint-Jérôme, Saint-Jérôme, QC (Y.P.), and Centre de Santé et de Services Sociaux du Nord de Lanaudière-Centre Hospitalier Régional de Lanaud, Saint-Charles-Borromée, QC (S.K.) - all in Canada; Instituto Cardiovascular de Buenos Aires, Buenos Aires (D.C.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Heart Institute (InCor)-University of São Paulo Medical School, São Paulo (J.C.N.); Hospital Central Dr. Ignacio Morones Prieto, San Luis Potosi, Mexico (J.L.L.-P.); the First Affiliated Hospital of Harbin Medical University, Harbin, China (W.L.); and South Oklahoma Heart Research, Oklahoma City (N.T.).
    Background: The cholesteryl ester transfer protein inhibitor evacetrapib substantially raises the high-density lipoprotein (HDL) cholesterol level, reduces the low-density lipoprotein (LDL) cholesterol level, and enhances cellular cholesterol efflux capacity. We sought to determine the effect of evacetrapib on major adverse cardiovascular outcomes in patients with high-risk vascular disease.

    Methods: In a multicenter, randomized, double-blind, placebo-controlled phase 3 trial, we enrolled 12,092 patients who had at least one of the following conditions: an acute coronary syndrome within the previous 30 to 365 days, cerebrovascular atherosclerotic disease, peripheral vascular arterial disease, or diabetes mellitus with coronary artery disease. Read More

    [Long-term results of different approaches to revascularization in non-ST-segment elevation acute coronary syndrome and multiple coronary atherosclerosis].
    Ter Arkh 2017 ;89(4):29-34
    Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.
    Aim: To assess the long-term results of different approaches to treating patients with non-ST-segment elevation acute coronary syndrome (NSTE ACS) and multivessel coronary artery disease (MVCAD).

    Subjects And Methods: A total of 150 patients with NSTE ACS, in whom coronary angiography revealed MVCAD, were examined. The patients were divided into 3 groups according to the selected treatment policy: 1) percutaneous coronary intervention (PCI) (n=91 (60. Read More

    Postoperative Assessment of Myocardial Function and Microcirculation in Patients with Acute Coronary Syndrome by Myocardial Contrast Echocardiography.
    Med Sci Monit 2017 May 17;23:2324-2332. Epub 2017 May 17.
    Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China (mainland).
    BACKGROUND Postoperative myocardial function and microcirculation of acute coronary syndrome (ACS) was assessed by myocardial contrast echocardiography (MCE). MATERIAL AND METHODS Eighty-nine ACS patients treated with percutaneous coronary intervention (PCI) were detected by MCE and two-dimensional ultrasonography before and a month later after PCI respectively. Their myocardial perfusion was evaluated by myocardial contrast score (MSC) and contrast score index (CSI); cross-sectional area of microvessel (A), average myocardial microvascular impairment (β), and myocardial blood flow (MBF) were analyzed by cardiac ultrasound quantitative analysis (CUSQ), and fractional flow reserve (FFR) change was observed. Read More

    Experience of exclusion: A framework analysis of socioeconomic factors affecting cardiac rehabilitation participation among patients with acute coronary syndrome.
    Eur J Cardiovasc Nurs 2017 May 1:1474515117711590. Epub 2017 May 1.
    5 University of Copenhagen, Rigshospitalet, Intensive Care Unit 4131, Denmark.
    Background: The Danish public healthcare system provides comprehensive care based on the principle of equal access. However, it is well documented that patients with low socioeconomic position are less likely to participate in cardiac rehabilitation. More knowledge is needed to understand this phenomenon. Read More

    Effect of Intensive Blood Pressure Lowering on Left Ventricular Hypertrophy in Patients with Hypertension: The Systolic Blood Pressure Intervention (SPRINT) Trial.
    Circulation 2017 May 16. Epub 2017 May 16.
    Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.
    Background -It is currently unknown whether intensive blood pressure (BP) lowering beyond that recommended would lead to more lowering of the risk of Left ventricular hypertrophy (LVH) in patients with hypertension, and whether reducing the risk of LVH explains the reported cardiovascular disease (CVD) benefits of intensive BP lowering in this population. Methods -This analysis included 8,164 participants (mean age 67.9 years, 35. Read More

    Acute coronary syndrome patients admitted to a cardiology vs non-cardiology service: variations in treatment & outcome.
    BMC Health Serv Res 2017 May 16;17(1):354. Epub 2017 May 16.
    Division of Cardiology and Department of Medicine, and Mazankowski Alberta Heart Insitute, University of Alberta, Edmonton, Canada.
    Background: Specialized cardiology services have contributed to reduced mortality in acute coronary syndromes (ACS).  We sought to evaluate the outcomes of ACS patients admitted to non-cardiology services in Southern Alberta.

    Methods: Retrospective chart review performed on all troponin-positive patients in the Calgary Health Region identified those diagnosed with ACS by their attending team. Read More

    Incidence of Metabolic Syndrome in Patients Admitted to Medical Wards with ST Elevation Myocardial Infarction.
    J Clin Diagn Res 2017 Mar 1;11(3):OC17-OC20. Epub 2017 Mar 1.
    Lecturer, Department of Microbiology, Government Medical College, Manjeri, Kerala, India.
    Introduction: Metabolic Syndrome (MS) consists of a cluster of metabolic abnormalities that confer exaggerated risk of cardiovascular disease. MS is a novel risk factor for Coronary Artery Disease (CAD) and is a rising disease entity in Asia. Incidence of ST Elevation Myocardial Infarction (STEMI) is high in patients with MS. Read More

    Statin Induced Rhabdomyolysis with Non Oliguric Renal Failure: A Rare Presentation.
    J Clin Diagn Res 2017 Mar 1;11(3):FD01-FD02. Epub 2017 Mar 1.
    Professor, Department of Cardiology, KMC Manipal University, Manipal, Karnataka, India.
    Statins are safe, well tolerated, efficient and time tested drugs for the management of hypercholesterolemia, and thus play a cardinal role in the management of patients with heart disease. Although safe in clinical practice, they are associated with adverse effects, clinically the most important and most severe being muscle related complications/myotoxicity. Rhabdomyolysis, though rare, is the most severe form of myotoxicity. Read More

    A Prospective Analysis of Drug Interactions in Patients of Intensive Cardiac Care Unit.
    J Clin Diagn Res 2017 Mar 1;11(3):FC01-FC04. Epub 2017 Mar 1.
    Associate Professor, Pharmaceutical Research and Officer-in-charge of Central Research lab, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India.
    Introduction: Drug-Drug Interaction (DDI) is a serious concern in cardiac patients due to polypharmacy.

    Aim: The present study was aimed to identify the potential DDI among hospitalized cardiac patients and evaluate the mechanism and severity of such interactions.

    Materials And Methods: A prospective observational study was conducted in intensive cardiac care unit of a tertiary care hospital for six months. Read More

    [Social support status and related influential factors of patients with acute coronary syndrome].
    Zhonghua Xin Xue Guan Bing Za Zhi 2017 May;45(5):399-403
    Department of Cardiology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
    Objectives: To investigate the social support status, related influential factors and the impact on one year outcome in patients with acute coronary syndrome (ACS), our data might be helpful to provide basis for making new treatment strategy aimed at improving social support for patients with ACS. Methods: From January 2013 to June 2014, a total of 778 hospitalized patients with ACS were enrolled in the study. All patients completed enhancing recovery in coronary heart disease patients social support inventory(ESSI), general anxiety disorder scale(GAD-7), patient health questionnaire(PHQ-9), short-form 12 health survey questionnaire(SF-12), sleep questionnaire and demographic questionnaire within 7 days after admission and at 6 months and one year post discharge. Read More

    Benefit of switching dual antiplatelet therapy after acute coronary syndrome: the TOPIC (timing of platelet inhibition after acute coronary syndrome) randomized study.
    Eur Heart J 2017 May 16. Epub 2017 May 16.
    Département de Cardiologie, CHU Timone, Marseille F-13385, France.
    Aims: Newer P2Y12 blockers (prasugrel and ticagrelor) demonstrated significant ischaemic benefit over clopidogrel after acute coronary syndrome (ACS). However, both drugs are associated with an increase in bleeding complications. The objective of the present study was to evaluate the benefit of switching dual antiplatelet therapy (DAPT) from aspirin plus a newer P2Y12 blocker to aspirin plus clopidogrel 1 month after ACS. Read More

    Spontaneous Coronary Artery Dissection: Insights From Histology and Optical Coherence Tomography.
    Rev Cardiovasc Med 2017 ;18(1):44-52
    Cedars Sinai Heart Institute, Los Angeles, CA.
    Spontaneous coronary artery dissection (SCAD) is a well-known but infrequent cause of acute coronary syndrome (ACS), and often goes unrecognized. Although management of SCAD is, at times, controversial, when a patient presents with ACS, percutaneous coronary intervention (PCI) is frequently necessary. We present a patient with ST-segment elevation myocardial infarction (STEMI) with SCAD that illustrates two important points: use of intracoronary optical coherence tomography to guide PCI, and histologic assessment to provide a unique insight into the etiology of SCAD. Read More

    Spontaneous Coronary Artery Dissection: A Review of Pathogenesis, Presentations, Treatment, and Outcomes.
    Rev Cardiovasc Med 2017 ;18(1):29-36
    Baylor University Medical Center, Division of Cardiology, Dallas, TX; Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, TX; Texas A&M College of Medicine, Bryan, TX.
    Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndromes and sudden cardiac death. The epidemiology, pathogenesis, and optimal approaches to diagnosis and management are poorly understood. Additionally, SCAD as a syndrome is commonly under-recognized and its prognosis is not well studied. Read More

    Yield of Cardiac Magnetic Resonance Imaging in Patients With Acute Coronary Syndrome and No Obstructive Coronary Artery Disease.
    Crit Pathw Cardiol 2017 Jun;16(2):58-61
    From the *Providence Health Care Research Institute, Vancouver, British Columbia, Canada; and †Vancouver General Hospital, Vancouver, British Columbia, Canada.
    Purpose: Ten percent to 25% of women and 6%-10% of men with acute coronary syndrome (ACS) are found to have no obstructive coronary artery disease (CAD) on coronary computed tomography angiogram or invasive coronary angiography. The etiology of presentation is often unclear. We examined the diagnostic yield of cardiac magnetic resonance imaging (CMR) in patients with signs and symptoms suggestive of an ACS and no obstructive CAD. Read More

    Effectiveness of 2-hour Troponin in High-risk Patients With Suspected Acute Coronary Syndrome.
    Crit Pathw Cardiol 2017 Jun;16(2):53-57
    From the Saint Joseph's Regional Medical Center, Paterson, NJ.
    Background: Research has shown the safety and effectiveness of drawing a standard troponin level at presentation and again at 2 hours in only low-risk patients. Because high-sensitivity troponins are not currently approved in the United States, we studied the utility of a standard troponin that is presently in use. Our goal was to determine if 2-hour standard troponin would be safe and effective in the evaluation of a high-risk cohort of patients never studied previously. Read More

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