1,188,071 results match your criteria Acute Bacterial Prostatitis and Prostatic Abscess


Correlation of UGT2B7 Polymorphism with Cardiotoxicity in Breast Cancer Patients Undergoing Epirubicin/Cyclophosphamide-Docetaxel Adjuvant Chemotherapy.

Yonsei Med J 2019 Jan;60(1):30-37

Department of Thyroid and Breast Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Purpose: The present study aimed to investigate correlations between uridine glucuronosyltransferase 2B7 (UGT2B7) -161 single nucleotide polymorphism C to T (C>T) and the occurrence of cardiotoxicity in Chinese breast cancer (BC) patients undergoing epirubicin/cyclophosphamide-docetaxel (EC-D) adjuvant chemotherapy.

Materials And Methods: 427 BC patients who had underwent surgery were consecutively enrolled in this prospective cohort study. All patients were scheduled to receive EC-D adjuvant chemotherapy regimen, and they were divided into UGT2B7 -161 CC (n=141), UGT2B7 -161 CT (n=196), and UGT2B7 -161 TT (n=90) groups according to their genotypes. Read More

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January 2019

Cases of prolonged mild disturbance of consciousness and acute encephalopathy.

Pediatr Int 2018 Dec 15. Epub 2018 Dec 15.

Division of Neurology, National Center for Child Health and Development, Tokyo, Japan 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.

Background: Acute encephalopathy (AE) is defined by the Japanese guidelines as the acute disturbance of consciousness (Glasgow Coma Scale score ≤11) that persists for more than 24 hours. However, we have often encountered cases of prolonged mild disturbance of consciousness (PMDC) with Glasgow Coma Scale scores >11 that do not fit the definition of acute encephalopathy by the guidelines. The reports of these cases have been relatively sparse, and their nosological position, prognosis, and other characteristics remain unknown. Read More

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December 2018

Management of Cerebral Microbleeds in Clinical Practice.

Transl Stroke Res 2018 Dec 15. Epub 2018 Dec 15.

Stroke Program, Department of Medicine, University of Alberta, Edmonton, T6G 2G3, Canada.

Cerebral microbleeds (CMBs) are very frequent diagnoses with MRI imaging in the elderly or in patients with cerebral infarction, intracranial hemorrhage (ICH), and dementia. The mechanisms for CMBs are not fully understood but may be secondary to injury to the vascular wall from long-standing hypertension or amyloid deposition in the tissue. The presence of CMB increases the risk for stroke, dementia, and death. Read More

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December 2018
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Intraoperative stent placement for the treatment of acute portal vein complications in pediatric living donor liver transplantation.

Langenbecks Arch Surg 2018 Dec 15. Epub 2018 Dec 15.

Department of General Surgery, Division of HPB Surgery and Liver Transplant Unit, Hospital Italiano de Buenos Aires, Juan D. Peron 4190, C1181ACH, Buenos Aires, Argentina.

Purpose: Pediatric living donor liver transplantation (LDLT) in low weight recipients remains one of the most complex surgical procedures, with portal vein (PV) complications occurring in up to 19% of cases. When decreased PV flow is diagnosed intra- or perioperatively, intraoperative stent placement is a good substitute for surgical adjustment. Still, at the present moment, little is known about the technical feasibility, safety, efficacy, and long-term outcome of intraoperative stenting in LDLT. Read More

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December 2018

Sudden unexpected infantile death due to undiagnosed ventricular septal defect-associated heart failure with single coronary artery.

Forensic Sci Med Pathol 2018 Dec 15. Epub 2018 Dec 15.

Department of Legal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.

Ventricular septal defect (VSD) generally has a good prognosis unless complicated by heart failure (HF). We report a case of sudden infant death because of clinically undiagnosed VSD in a seemingly healthy 16-day-old boy. Although a cardiac murmur was auscultated at birth, detailed clinical examination was not performed. Read More

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December 2018
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Classification of the superior angle of the scapula and its correlation with the suprascapular notch: a study on 303 scapulas.

Surg Radiol Anat 2018 Dec 15. Epub 2018 Dec 15.

Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China.

Purpose: The aims of this study had been to classify the superior angle of the scapula based on morphological features, and to investigate its correlation with the suprascapular notch.

Methods: 303 samples of Chinese dried scapular specimens were collected from the Department of anatomy, Southwest Medical University. According to the anatomical morphological characteristics of the superior angle of the scapula, the morphological classification was performed to explore its correlation with the suprascapular notch (SSN). Read More

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December 2018
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Association between glycemic control, age, and outcomes among intensively treated patients with acute myeloid leukemia.

Support Care Cancer 2018 Dec 15. Epub 2018 Dec 15.

Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.

Purpose: To investigate the impact of hyperglycemia and glycemic variability during intensive acute myeloid leukemia therapy (AML) on outcomes by age.

Methods: Retrospective study of 262 consecutive patients with newly diagnosed AML hospitalized for intensive induction. Hyperglycemia was assessed by mean blood glucose (BG) (mg/dL) during hospitalization and glycemic variability was determined by the standard deviation (SD) of mean BG. Read More

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December 2018

Italian Translation and Cross-Cultural Adaptation of a Back Pain Screening Questionnaire (Start Back Screening Tool).

Ann Ig 2019 Jan-Feb;31(1):69-75

Research Department, Accademia Italiana di Medicina Osteopatica (AIMO), Saronno, Italy.

Background: Low back pain is a heterogeneous condition, from which most patients recover after a few months. However, a considerable proportion of patients develop chronic pain despite different types of treatment. Primary care evidence-based guidelines for non-specific back pain highlight the importance of identifying indicators of poor prognosis in order for treatment to be appropriately targeted. Read More

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December 2018

Correlations of Acute Cerebral Hemorrhage Complicated with Stress Ulcer Bleeding with Acute Physiology and Chronic Health Evaluation (APACHE) II Score, Endothelin (ET), Tumor Necrosis Factor-alpha (TNF-α), and Blood Lipids.

Med Sci Monit 2018 Dec 16;24:9120-9126. Epub 2018 Dec 16.

Department of Gastroenterology, Tai'an Central Hospital, Tai'an, Shandong, China (mainland).

BACKGROUND This study investigated the correlations between acute cerebral hemorrhage complicated with stress ulcer bleeding and corresponding indexes, including the Acute Physiology and Chronic Health Evaluation (APACHE) II score, vascular endothelin-1 (ET-1), tumor necrosis factor-alpha (TNF-α), and blood lipid factors. MATERIAL AND METHODS A total of 53 patients with acute cerebral hemorrhage complicated with stress ulcer bleeding were selected as the observation group and 50 patients with simple acute cerebral hemorrhage were selected as the control group. The APACHE II score and the levels of ET-1, TNF-α, and blood lipid factors, including total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and malondialdehyde (MDA), were detected and the correlations of were analyzed between the 2 groups of patients. Read More

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December 2018

Recurrence Patterns and Outcomes of Salvage Surgery in Cases of Non-Curative Endoscopic Submucosal Dissection without Additional Radical Surgery for Early Gastric Cancer.

Digestion 2018 Dec 14;99(1):52-58. Epub 2018 Dec 14.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background/aims: The outcomes of salvage surgery for recurrence after non-curative endoscopic submucosal dissection (ESD) without additional radical surgery for early gastric cancer (EGC) remain unclear. We determined the recurrence patterns and outcomes of salvage surgery in such cases using data from a multicenter, retrospective study.

Methods: Of 15,785 patients who underwent ESD for EGC at 19 participating institutions between January 2000 and August 2011, 1,969 failed to meet the current curative criteria after ESD. Read More

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December 2018
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The REACH Trial: A Randomized Controlled Trial Assessing the Safety and Effectiveness of the Spiration® Valve System in the Treatment of Severe Emphysema.

Respiration 2018 Dec 14:1-12. Epub 2018 Dec 14.

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou,

Background: Chronic obstructive pulmonary disease (COPD) has become a leading cause of morbidity and mortality in China, with tobacco smoke, air pollution, and occupational biohazards being the major risk factors.

Objectives: The REACH trial is a multicenter, prospective, randomized controlled trial undertaken in China to assess the safety and effectiveness of the Spiration® Valve System (SVS) compared to standard medical care in COPD patients with severe emphysema.

Methods: Patients with severe airflow obstruction, hyperinflation, and severe dyspnea with interlobar fissure integrity were evaluated for enrollment. Read More

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December 2018

Transbronchial Cryobiopsies for Diagnosing Interstitial Lung Disease: Real-Life Experience from a Tertiary Referral Center for Interstitial Lung Disease.

Respiration 2018 Dec 14:1-7. Epub 2018 Dec 14.

Center for Interstitial and Rare Lung Diseases, Thoraxklinik, University of Heidelberg, Heidelberg,

Background: Transbronchial cryobiopsy (cTBB) may offer an alternative to surgical lung biopsy (SLB) for histopathological diagnosis of interstitial lung diseases (ILDs). However, real-life experience is limited, although case series are increasingly reported.

Objectives: We aimed to evaluate the value of cTBB performed under real-life conditions in a tertiary care center for ILDs. Read More

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December 2018

Contralateral acute vascular occlusion following revascularization surgery for moyamoya disease.

Authors:

J Neurosurg 2018 Dec 14:1-7. Epub 2018 Dec 14.

OBJECTIVERevascularization surgery is a safe and effective surgical treatment for symptomatic moyamoya disease (MMD) and has been shown to reduce the frequency of future ischemic events and improve quality of life in affected patients. The authors sought to investigate the occurrence of acute perioperative occlusion of the contralateral internal carotid artery (ICA) with contralateral stroke following revascularization surgery, a rare complication that has not been previously reported.METHODSThis study is a retrospective review of a prospective database of a single surgeon's series of revascularization operations in patients with MMD. Read More

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December 2018

Impact of cerebral blood flow changes due to arterial bypass surgery on cognitive function in adult patients with symptomatic ischemic moyamoya disease.

Authors:

J Neurosurg 2018 Dec 14:1-9. Epub 2018 Dec 14.

OBJECTIVESome adult patients with moyamoya disease (MMD) undergoing revascularization surgery show an improvement or decline in cognition postoperatively. Revascularization surgery for ischemic MMD augments cerebral blood flow (CBF) and improves cerebral oxygen metabolism. However, cerebral hyperperfusion, which is a short-term, major increase in ipsilateral CBF that is much greater than the metabolic needs of the brain, sometimes occurs as a complication. Read More

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December 2018

Use of Consensus Methodology to Determine Candidate Items for Systemic Lupus Erythematosus Classification Criteria.

J Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

S.R. Johnson MD PhD FRCPC, Division of Rheumatology, Department of Medicine, Toronto Western Hospital, Mount Sinai Hospital; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. D. Khanna MD MS, Division of Rheumatology, Department of Medicine, University of Michigan, USA. R. Cervera MD PhD FRCP, Hospital Clínic, Barcelona, Spain. N. Costedoat-Chalumeau MD PhD AP-HP, Cochin Hospital, Internal Medicine Department, Centre de référence maladies auto-immunes et systémiques rares d'île de France, Paris, France ; Université Paris Descartes-Sorbonne Paris Cité, Paris, France ; INSERM U 1153, Center for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France. D.D. Gladman MD FRCPC, Division of Rheumatology, Department of Medicine, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada. B.H. Hahn MD, University of California Los Angeles, Los Angeles, USA. F. Hiepe MD, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Charitéplatz 1, 10117 Berlin, Germany. J. Sánchez-Guerrero MD MSc, Division of Rheumatology, Department of Medicine Mount Sinai Hospital/University Health Network, University of Toronto, Toronto, Ontario, Canada; and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. E. Massarotti MD, Brigham and Women's Hospital, Boston MA; Harvard Medical School, Boston, USA. D.T. Boumpas MD FACP FACR, National and Kapodestrian University of Athens, and Biomedical Research Foundation of the Athens Academy, Athens, Greece. K.H Costenbader MD MPH, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, USA. D. Daikh MD, University of California, San Francisco, USA. D. Jayne MD FRCP FRCPE FMedSci, Department of Medicine, University of Cambridge, United Kingdom. T. Dörner MD, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Charitéplatz 1, 10117 Berlin, Germany. D.L. Kamen MD MSCR, Medical University of South Carolina, Charleston, USA. M. Mosca MD PhD, University of Pisa, Italy. R. Ramsey-Goldman MD DrPH, Northwestern University Feinberg School of Medicine, Chicago, USA. J.S. Smolen MD, Medical University of Vienna, Austria. D. Wofsy MD, University of California, San Francisco, USA. M. Aringer MD, University Medical Center and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany. Address correspondence to Sindhu Johnson MD PhD, Division of Rheumatology, Ground Floor, East Wing, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada, M5T 2S8. Phone 1-416-603-6417 Fax.1-416-603- 4348. Email:

Objective: Given the complexity and heterogeneity of systemic lupus erythematosus (SLE), high performing classification criteria are critical to advancing research and clinical care. A collaborative effort by EULAR and ACR was undertaken to generate candidate criteria, and then to reduce them to a smaller set. The objective of the current study was to select a set of criteria that maximizes the likelihood of accurate classification of SLE, particularly early disease. Read More

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December 2018

Disruption of periaqueductal grey-default mode network functional connectivity predicts persistent post-traumatic headache in mild traumatic brain injury.

J Neurol Neurosurg Psychiatry 2018 Dec 15. Epub 2018 Dec 15.

Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

Objective: Post-traumatic headache (PTH) is one of the most frequent and persistent physical symptoms following mild traumatic brain injury (mTBI) and develop in more than 50% of this population. This study aimed to investigate the periaqueductal grey (PAG)-seeded functional connectivity (FC) in patients with mTBI with acute post-traumatic headache (APTH) and further examine whether the FC can be used as a neural biomarker to identify patients developing chronic pain 3 months postinjury.

Methods: 70 patients with mTBI underwent neuropsychological measurements and MRI scans within 7 days postinjury and 56 (80%) of patients were followed up at 3 months. Read More

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December 2018

Fiend and friend in the renin angiotensin system: An insight on acute kidney injury.

Biomed Pharmacother 2018 Dec 13;110:764-774. Epub 2018 Dec 13.

Laboratory of Molecular Pharmacology, Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Rajasthan 333 031, India. Electronic address:

Besides assisting the maintenance of blood pressure and sodium homeostasis, the renin-angiotensin system (RAS) plays a pivotal role in pathogenesis of acute kidney injury (AKI). The RAS is equipped with two arms i) the pressor arm composed of Angiotensin II (Ang II)/Angiotensin converting enzyme (ACE)/Angiotensin II type 1 receptor (AT1R) also called conventional RAS, and ii) the depressor arm consisting of Angiotensin (1-7) (Ang 1-7)/Angiotensin converting enzyme 2 (ACE2)/MasR known as non-conventional RAS. Activation of conventional RAS triggers oxidative stress, inflammatory, hypertrophic, apoptotic, and pro-fibrotic signaling cascades which promote AKI. Read More

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December 2018
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Simultaneous detection of three biomarkers related to acute myocardial infarction based on immunosensing biochip.

Biosens Bioelectron 2018 Dec 6;126:767-772. Epub 2018 Dec 6.

Jiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China. Electronic address:

An immunosensing biochip for simultaneous detection of three biomarkers related to acute myocardial infarction (AMI) was developed based on anionic soybean peroxidase (SBP) functionalized nanoprobe and chemiluminescent imaging. The nanoprobes (Ab2-SiO-SBP) were fabricated by co-immobilization of SBP and one of the detection polyclonal antibodies, anti-cardiac troponin I antigen (anti-cTnI), anti-creatine kinase-MB (anti-CK-MB) and anti-myoglobin (anti-Myo), on the silica nanoparticle surface. The detection sensitivity was enhanced since the large surface area of silica carriers increased the loading of SBP for per sandwiched immunoreaction. Read More

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December 2018

Innate T cells in the intensive care unit.

Mol Immunol 2018 Dec 13;105:213-223. Epub 2018 Dec 13.

Brigham and Women's Hospital, Pulmonary and Critical Care Medicine, Boston, MA, 02115, United States; Harvard Medical School, Boston, MA, 02115, United States.

Rapid onset of acute inflammation is a hallmark of critical illnesses that bring patients to the intensive care unit (ICU). In critical illness, innate T cells rapidly reach full activation and drive a robust acute inflammatory response. As "cellular adjuvants," innate T cells worsen inflammation and mortality in several common critical illnesses including sepsis, ischemia-reperfusion injury, stroke, and exacerbations of respiratory disease. Read More

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December 2018

Long-term disability in neuromyelitis optica spectrum disorder with a history of myelitis is associated with age at onset, delay in diagnosis/preventive treatment, MRI lesion length and presence of symptomatic brain lesions.

Mult Scler Relat Disord 2018 Dec 9;28:64-68. Epub 2018 Dec 9.

Johns Hopkins University, School of Medicine, Department of Neurology, Baltimore, MD, USA.

Background: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system (CNS) that preferentially targets the spinal cord and optic nerves. Increasing disability is accrued with each inflammatory attack. Disability has been shown to be an independent predictor of poor quality of life in those with NMOSD. Read More

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December 2018

Outcomes from acute attacks of neuromyelitis optica spectrum disorder correlate with severity of attack, age and delay to treatment.

Mult Scler Relat Disord 2018 Dec 10;28:60-63. Epub 2018 Dec 10.

Johns Hopkins University, Department of Neurology, Baltimore, MD, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Neuromyelitis optica spectrum disorder (NMOSD) attacks lead to incremental loss of function of the optic nerves and spinal cord. The standard of care for treatment of acute attacks to mitigate damage is high dose corticosteroids and, if needed, plasma exchange. Although the inclination among clinicians is to treat relapses as soon as they start, there is no previously published evidence to conclude that earlier treatment with corticosteroids is more effective in the long term. Read More

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December 2018

In-situ forming gels containing fluorometholone-loaded polymeric nanoparticles for ocular inflammatory conditions.

Colloids Surf B Biointerfaces 2018 Nov 27;175:365-374. Epub 2018 Nov 27.

Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain; Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Barcelona, Spain. Electronic address:

Thermosensitive gels have been developed and optimized in such a way that they become gels at corneal temperature and with a viscosity that allows the adequate release of the Fluorometholone (FMT)-loaded PLGA nanoparticles (NPs) in order to improve ocular anti-inflammatory efficacy against a commercial formulation. It has been shown that gels avoid burst release of the drug in the first hours with a slow and increasing profile after administration. NPs have maintained their average size and spherical shape within the gels as confirmed by transmission electron microscopy (TEM). Read More

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November 2018
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Fabrication of electrochemical biosensor composed of multi-functional DNA structure/Au nanospike on micro-gap/PCB system for detecting troponin I in human serum.

Colloids Surf B Biointerfaces 2018 Dec 7;175:343-350. Epub 2018 Dec 7.

School of Integrative Engineering Chung-Ang University, Heukseok-dong, Dongjak-gu, Seoul, 156-756, Republic of Korea. Electronic address:

Acute myocardial infarction (AMI) is one of the most serious diseases affecting human beings. In this study, in order to rapidly detect AMI disease, the authors fabricated a label-free electrochemical biosensor composed of a multi-functional DNA structure on Au nanospike (AuNS) with a fabricated Au micro-gap electrode which was incorporated with a PCB chip in order to detect cardiac troponin I (cTnI). As a bioprobe, the DNA 3 way-junction (3WJ) was introduced, because the DNA 3WJ has three arms for embodying the multi-functionality. Read More

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December 2018

Doppler-defined pulmonary hypertension in sepsis and septic shock.

J Crit Care 2018 Dec 8;50:201-206. Epub 2018 Dec 8.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, United States.

Background: The association of pulmonary hypertension (PH) in patients with sepsis is lesser understood.

Methods: This was a retrospective study of adult patients admitted to the intensive care unit during 2007-2014 for sepsis and septic shock, with echocardiography performed <72 h. PH was defined as tricuspid regurgitation peak velocity (TRV) > 3 m/s on Doppler echocardiography. Read More

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December 2018
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Atypical ischemic repolarization in right bundle branch block.

J Electrocardiol 2018 Dec 6;52:117-118. Epub 2018 Dec 6.

Department "A" Medical Area, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Belisario Domínguez - Sección XVI, Tlalpan, Mexico City PO 14080, Mexico.

A 70-year-old male presented to emergency room 16 h after the onset of acute chest pain. Initial ECG showed sinus rhythm with a wide QRS and right bundle branch block (RBBB) with concordant and symmetric T waves in V1-V2. A plausible explanation for the atypical positive T waves in leads V1-V2 in conjunction with RBBB could be non-reperfused lateral MI (LMI) as a "mirror-image" of inverted T waves in the posterior leads V7-V9. Read More

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December 2018

Diurnal cardiac sympathetic hyperactivity after exposure to acute particulate matter 2.5 air pollution.

J Electrocardiol 2018 Nov 15;52:112-116. Epub 2018 Nov 15.

Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital. Taiwan; Institute of Clinical Medicine, Cardiovascular Research Institute, National Yang-Ming University, Taiwan.

Background: Ambient fine particulate matter (PM2.5) exposure is associated with increased cardiovascular and cardiac arrhythmias events, but the detailed mechanism remains unclear.

Objective: We aimed to investigate the effect of PM2. Read More

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November 2018

The concentration of dissolved organic matter impacts the metabolic response in Daphnia magna exposed to 17α-ethynylestradiol and perfluorooctane sulfonate.

Ecotoxicol Environ Saf 2018 Dec 13;170:468-478. Epub 2018 Dec 13.

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, Canada M5S 3H6; Environmental NMR Centre and Department of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON, Canada M1C 1A4. Electronic address:

The pharmaceutical 17α-ethynylestradiol (EE2) and the industrial chemical perfluorooctane sulfonate (PFOS) are organic contaminants frequently detected in freshwater environments. It is hypothesized that hydrophobic organic contaminants can sorb to dissolved organic matter (DOM) and this may reduce the toxicity of these contaminants by reducing the contaminants' bioavailability. To investigate this hypothesis, H nuclear magnetic resonance (NMR)-based metabolomics was used to determine how the metabolome of Daphnia magna changes when a range of DOM concentrations are added during EE2 and PFOS exposure experiments. Read More

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December 2018

Frequency of superantigen encoding genes of Staphylococcus aureus isolates collected from multiple sclerosis (MS) patients and nasal carriers.

Microb Pathog 2018 Dec 13. Epub 2018 Dec 13.

Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Background: Bacterial superantigens are potent T cell activators that can have acute or chronic effects on the central nervous system.

Objectives: In this study, the role of enterotoxins, exfoliative toxins and toxic shock syndrome toxin of Staphylococcus aureus was investigated in MS patients and healthy nasal carriers.

Methods: Three-hundred fifty nasal swabs were collected from healthy nasal carriers (n = 210) and MS (n = 140) patients. Read More

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December 2018

Heart Failure and Liver Disease: Cardiohepatic Interactions.

JACC Heart Fail 2018 Dec 7. Epub 2018 Dec 7.

Department of Cardiology, Larissa University General Hospital, Larissa, Greece. Electronic address:

Heart failure (HF) and liver disease often co-exist. This is because systemic disorders and diseases affect both organs (alcohol abuse, drugs, inflammation, autoimmunity, infections) and because of complex cardiohepatic interactions. The latter, which are the focus of this review, include the development of acute cardiogenic liver injury and congestive hepatopathy in HF as well as cardiac dysfunction and failure in the setting of liver cirrhosis, nonalcoholic fatty liver disease, and sequelae following liver transplantation. Read More

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December 2018

Effects of parity and litter size on cortisol measures in commercially housed sows and their offspring.

Physiol Behav 2018 Dec 13. Epub 2018 Dec 13.

Behavior & Welfare Group, Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands; Brain Center Rudolf Magnus, Utrecht University, Utrecht, The Netherlands.

Breeding sows are regularly exposed to on-farm stressors throughout the duration of their production period. The impact of such stressors may differ for primi- and multiparous sows, as sows could learn to cope with stressors as they gain experience with them. If parity affects stress in sows, it may also impact their prenatal offspring through differential maternal stress. Read More

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December 2018

Food restriction, but not seasonality, modulates the acute phase response of a neotropical bat.

Comp Biochem Physiol A Mol Integr Physiol 2018 Dec 13. Epub 2018 Dec 13.

Departamento de Zoologia, Instituto de Biociências Universidade Estadual Paulista Julho de Mesquita Filho, Rio Claro, São Paulo, Brazil.

Season and food intake are known to affect immune response of vertebrates yet their effects on metabolic rate have been rarely explored. We tested the effect of season and acute food restriction and their interaction on the energetic cost of immune response activation of a tropical vertebrate, the Seba's short-tailed fruit bat (Carollia perspicillata). We specifically stimulated the acute phase response (APR) with bacterial lipopolysaccharide (LPS) to measure metabolic changes along with changes in body temperature (T), body mass (M), white blood cell counts and the Neutrophil/Lymphocyte ratio (N/L). Read More

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December 2018

Skim milk powder with high content of Maillard reaction products affect weight gain, organ development and intestinal inflammation in early life in rats.

Food Chem Toxicol 2018 Dec 13. Epub 2018 Dec 13.

Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Sweden; Skane University Hospital, Department of Endocrinology, Lund, Sweden. Electronic address:

Background: The intestinal tract is important for development of immune tolerance and disturbances are suggested to trigger autoimmune disorders. The aim of this study was to explore the effect of Maillard products in skim milk powder obtained after long storage, compared to fresh skim milk powder.

Methods: Young rats were weaned onto a diet based on skim milk powder with high concentration of Maillard products (HM-SM, n = 18) or low (C-SM, n = 18) for one week or four weeks. Read More

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December 2018

Effectiveness of acute transcranial direct current stimulation on non-motor and motor symptoms in Parkinson´s disease.

Neurosci Lett 2018 Dec 13. Epub 2018 Dec 13.

State University of Londrina, Robert Koch Av., 60, Londrina, Paraná, Brazil. Electronic address:

Background: Transcranial direct current stimulation (tDCS) is an appropriate treatment for Parkinson's disease (PD). It offers promising results and is known to improve symptoms. Nevertheless, consistent parameters need to be established for research purposes. Read More

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December 2018

Augmenter of liver regeneration protects against ethanol-induced acute liver injury by promoting autophagy.

Am J Pathol 2018 Dec 13. Epub 2018 Dec 13.

Department of Cell Biology, Capital Medical University and the Municipal Key Laboratory for Liver Protection and Regulation of Regeneration, Beijing, China. Electronic address:

Alcoholic liver disease is associated with high morbidity and mortality, and treatment options are limited to date. Augmenter of liver regeneration (ALR) may protect against hepatic injury caused by chemical poisons, including ethanol. Autophagy appears to positively influence survival in cases of liver dysfunction, though the mechanisms are poorly understood. Read More

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December 2018

Expression of Bone Morphogenetic Proteins In Multiple Sclerosis Lesions.

Am J Pathol 2018 Dec 13. Epub 2018 Dec 13.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Universitat Autònoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallès), Spain. Electronic address:

Bone morphogenetic proteins (BMPs) are secreted proteins that belong to the transforming growth factor-beta superfamily. In the adult brain, they modulate neurogenesis, favor astrogliogenesis, and inhibit oligodendrogenesis. As BMPs may be involved in the failure of remyelination in multiple sclerosis (MS), we characterized the expression of BMP-2, -4, -5, and -7; BMP type II receptor (BMPRII); and phosphorylated (p)SMAD 1/5/8 in lesions of MS and other demyelinating diseases. Read More

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December 2018

The critical role of microRNAs in stress response: therapeutic prospect and limitation.

Pharmacol Res 2018 Dec 13. Epub 2018 Dec 13.

Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, China; National Clinical Research Center for Geriatric Disorders (XIANGYA), Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. Electronic address:

Stress response refers to the systemic nonspecific response upon exposure to strong stimulation or chronic stress, such as severe trauma, shock, infection, burn, major surgery or improper environment, which disturb organisms and damage their physical and psychological health. However, the pathogenesis of stress induced disorder remains complicated and diverse under different stress exposure. Recently, studies have revealed a specific role of microRNAs (miRNAs) in regulating cellular function under different types of stress, suggesting a significant role in the treatment and prevention of stress-related diseases, such as stress ulcer, posttraumatic stress disorder, stress-induced cardiomyopathy and so on. Read More

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December 2018

Interhospital Variability in Acute Coronary Syndrome Management in the ATHOS Study.

Rev Esp Cardiol (Engl Ed) 2018 Dec 12. Epub 2018 Dec 12.

Grupo REGICOR, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain; CIBERCV de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

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December 2018

Acute Vibration Induces Peripheral Nerve Sensitization in a Rat Tail Model: Possible Role of Oxidative Stress and Inflammation.

Neuroscience 2018 Dec 13. Epub 2018 Dec 13.

Engineering and Controls Technology Branch, National Institute for Occupational Safety and Health, Morgantown, WV, 26501, United States. Electronic address:

Prolonged occupational exposure to hand-held vibrating tools leads to pain and reductions in tactile sensitivity, grip strength and manual dexterity. The goal of the current study was to use a rat-tail vibration model to determine how vibration frequency influences factors related to nerve injury and dysfunction. Rats were exposed to restraint, or restraint plus tail vibration at 62. Read More

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December 2018

Sex differences in cerebral perfusion changes after mild traumatic brain injury: Longitudinal investigation and correlation with outcome.

Brain Res 2018 Dec 13. Epub 2018 Dec 13.

Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. Electronic address:

Cerebral blood flow (CBF) is known to have marked developmental sex differences. We investigated whether gender differences exert modulatory effect on mild traumatic brain injury (mTBI) from both neuropsychological testing and brain CBF changes using a longitudinal design from acute stage to subacute 1 month post-injury. Our results supported that cognitive information processing speed (IPS), as one of core cognitive impairments following mTBI, were at least partially independent from other self-reported syndromes, such as post concussive symptom and posttraumatic stress disorder, and that it can be selectively impaired in specific male mTBI individuals. Read More

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December 2018

Smc3 is required for mouse embryonic and adult hematopoiesis.

Exp Hematol 2018 Dec 13. Epub 2018 Dec 13.

Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri. Electronic address:

SMC3 encodes a subunit of the cohesin complex that has canonical roles in regulating sister chromatids segregation during mitosis and meiosis. Recurrent heterozygous mutations in SMC3 have been reported in acute myeloid leukemia (AML) and other myeloid malignancies. In this study, we investigated whether the missense mutations in SMC3 might have dominant-negative effects or phenocopy loss-of-function effects by comparing the consequences of Smc3 deficient and haploinsufficient mouse models. Read More

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December 2018

Incidence, Cost, and Risk Factors for Readmission after Coronary Artery Bypass Grafting.

Ann Thorac Surg 2018 Dec 13. Epub 2018 Dec 13.

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX. Electronic address:

Background: Readmissions adversely affect hospital reimbursement and quality measures. We aimed to evaluate the incidence, cost, and risk factors for readmission following Coronary Artery Bypass Grafting (CABG).

Methods: We queried the National Readmissions Database (NRD) and isolated patients who underwent CABG from 2013-2014. Read More

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December 2018
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Impact of Complications on Resource Utilization during 90-day CABG Bundle for Medicare Beneficiaries.

Ann Thorac Surg 2018 Dec 13. Epub 2018 Dec 13.

HealthTrust Purchasing Group, L.P.

Background: The study reports the impact of adverse events during the index CABG surgery on Medicare reimbursement for the index hospitalization and a 90-day follow-up period.

Methods: This retrospective study used 2014 Medicare claims files for hospitals, skilled nursing services, rehabilitation facilities, long-term care facilities, home health services and outpatient visits. The study sample is 37,106 Medicare beneficiaries that survived an index CABG in a US hospital during the first three quarters of 2014. Read More

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December 2018

Implications of secondary aortic intervention after thoracic endovascular aortic repair for acute and chronic type B dissection.

J Vasc Surg 2018 Dec 12. Epub 2018 Dec 12.

Division of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, Fla.

Background: Thoracic endovascular aortic repair (TEVAR) has become a mainstay of therapy for acute and chronic type B aortic dissection (TBAD). Dynamic aortic morphologic changes, untreated dissected aorta, and persistent false lumen perfusion have significant consequences for reintervention after TEVAR for TBAD. However, few reports contrast differences in secondary aortic intervention (SAI) after TEVAR for TBAD or describe their influence on mortality. Read More

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December 2018

Spontaneous Left Anterior Descending Coronary Artery Dissection in a Teenager.

JACC Cardiovasc Interv 2018 Dec 7. Epub 2018 Dec 7.

Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Milan, Italy; Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.

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December 2018

Individual Operator Experience and Outcomes in Transcatheter Aortic Valve Replacement.

JACC Cardiovasc Interv 2018 Dec 7. Epub 2018 Dec 7.

Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, New York. Electronic address:

Objectives: The aim of this study was to assess the impact of individual operator experience on transfemoral transcatheter aortic valve replacement (TAVR) outcomes.

Background: TAVR volume-outcome relationships have not been evaluated at the individual operator level.

Methods: New York Statewide Planning and Research Cooperative System data from 8,771 transfemoral TAVR procedures performed by 207 operators between 2012 and 2016 were analyzed. Read More

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December 2018

Cannabis induced increase in striatal glutamate associated with loss of functional corticostriatal connectivity.

Eur Neuropsychopharmacol 2018 Dec 12. Epub 2018 Dec 12.

Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

Cannabis is the most commonly used illicit drug and is known to alter state of consciousness and impair neurocognitive function. However, the mechanisms underlying these effects have yet to be fully elucidated. Rodent studies suggest that Δ9-tetrahydrocannabinol (THC) activates dopaminergic neurons in the limbic system, subsequently enhancing dopamine, which is implicated in the rewarding effects of cannabis. Read More

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December 2018

Changes in Coronary Plaque Composition in Patients With Acute Myocardial Infarction Treated With High-Intensity Statin Therapy (IBIS-4): A Serial Optical Coherence Tomography Study.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, Bern University Hospital, Bern, Switzerland.

Objectives: This study assessed changes in optical coherence tomography (OCT)-defined plaque composition in patients with ST-elevation myocardial infarction (STEMI) receiving high-intensity statin treatment.

Background: OCT is a high-resolution modality capable of measuring plaque characteristics including fibrous cap thickness (FCT) and macrophage infiltration. There is limited in vivo evidence regarding the effects of statins on OCT-defined coronary atheroma composition and no evidence in the context of STEMI. Read More

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December 2018

Understanding the Tides of Myocardial Infarction.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Departments of Medicine and Diagnostic Radiology, McGill University Health Centre, Montreal, Quebec, Canada; Department of Medicine, Heidelberg University, Heidelberg, Germany; Department of Radiology, Université de Montréal, Montreal, Quebec, Canada; Department of Medicine and Radiology, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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December 2018

Histopathologic Characterization of Peripheral Arteries in Subjects With Abundant Risk Factors: Correlating Imaging With Pathology.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

CVPath Institute, Gaithersburg, Maryland.

Objectives: The aim of this study was to comprehensively evaluate the pathology of the lower extremity arteries across their entire length in subjects dying with abundant risk factors and to evaluate the clinical and imaging implications of the pathological characteristics.

Background: Lower extremity peripheral arterial disease is a major cause of cardiovascular morbidity, but a systematic characterization of the pathology has never been undertaken.

Methods: Twelve legs were obtained from 8 cadavers with histories of coronary risk factors (median age 82 years, 6 men); 8 of 12 legs were evaluated using computed tomography before the major peripheral arteries were dissected along their entire length. Read More

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December 2018
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