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BMJ Open 2022 May 17;12(5):e054566. Epub 2022 May 17.

International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China

Background: Chronic Sciatica is a disabling condition causing considerable medical, social and financial implications. Currently, there is no recognised long-term effective treatment to alleviate sciatica. Acupuncture has been widely used for treating chronic pains with persistent analgesic effects. Read More

BMJ Open 2022 May 17;12(5):e054158. Epub 2022 May 17.

First Clinical College, Hubei University of Chinese Medicine, Wuhan, China

Introduction: Osteoporosis (OP) is a prevalent skeletal disease with high mortality and morbidity, followed by acute and chronic back pain, severe spinal deformity and dysfunction. First-line drugs for OP work through antiresorptive or anabolic mechanisms. Although with good efficacy, these drugs still have certain limitations in clinical application due to delivery routes, medication cycles and cost issues. Read More

Geriatr Nurs 2022 May 14;46:13-20. Epub 2022 May 14.

Nursing College, Fujian University of Traditional Chinese Medicine, No.1 Qiu Yang Road, Shangjie, Minhou, Fuzhou, Fujian 350122, China. Electronic address:

Objective: To systematically evaluate the effects of acupuncture in patients with unilateral spatial neglect (USN) after stroke.

Data Sources: Relevant English- and Chinese- language studies published until 12th February 2022, were retrieved from China National Knowledge Infrastructure (CNKI), Wanfang, China Scientific Journals Database (VIP), SinoMed, PubMed, Cochrane Library, Embase, Web of Science and OVID.

Review Methods: Randomized controlled trials (RCTs) assessing the effects of acupuncture in patients with USN after stroke were included. Read More

Acupunct Med 2022 May 17:9645284221085578. Epub 2022 May 17.

Nanjing Maigaoqiao Community Health Service Center, Nanjing, China.

J Cosmet Dermatol 2022 May 17. Epub 2022 May 17.

Molecular Dermatology Research Center, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Chronic pruritus is one of the most common conditions in dermatology as well as a common manifestation in many systemic diseases. Since the etiology of chronic pruritus remains somewhat unknown, hence, conventional medications may not always show a good therapeutic response. This finding has led both investigators and patients to use herbal and complementary remedies for its treatment. Read More

Bone Joint Res 2022 May;11(5):304-316

Department of Convergence Korean Medical Science, Graduate School, College of Korean Medicine, Kyung Hee University, Seoul, South Korea.

Aims: The association of auraptene (AUR), a 7-geranyloxycoumarin, on osteoporosis and its potential pathway was predicted by network pharmacology and confirmed in experimental osteoporotic mice.

Methods: The network of AUR was constructed and a potential pathway predicted by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) terms enrichment. Female ovariectomized (OVX) Institute of Cancer Research mice were intraperitoneally injected with 0. Read More

Acupunct Med 2022 May 17:9645284221086293. Epub 2022 May 17.

Internal Medicine B Department, Bnai Zion Medical Center, Haifa, Israel.

Background: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a healthcare burden. Acupuncture improves dyspnea in patients with chronic obstructive pulmonary disease (COPD) but, to the best of our knowledge, has not been tested in AECOPD. Here, we evaluated the efficacy and safety of true acupuncture added to standard of care (SOC), as compared with both sham procedure plus SOC and SOC only, for the treatment of AECOPD among inpatients. Read More

Acupunct Med 2022 May 17:9645284221086288. Epub 2022 May 17.

Shandong University of Traditional Chinese Medicine, Jinan, China.

Background: Sepsis is a life-threatening organ dysfunction caused by dysregulation of the host response to infection. Acupuncture is used for treatment of inflammatory diseases; however, its effectiveness and safety as a complementary therapy for sepsis has not been fully explored.

Methods: Data were retrieved from eight databases. Read More

Acupunct Med 2022 May 17:9645284221085579. Epub 2022 May 17.

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.

Objective: To visualize and compare the sensory and autonomic innervation of the local tissues at the sites of different traditional acupuncture points in the rat forehead and face by histochemical examination.

Methods: GB14 (), ST2 () and ST6 () were selected as the representative traditional acupuncture points in this study, and the local tissues at these sites were dissected in rats after perfusion followed by double or triple fluorescent histochemical staining. Here, calcitonin gene-related peptide (CGRP), tyrosine hydroxylase (TH) and vesicular acetylcholine transporter (VAChT) were used to label the sensory, sympathetic and parasympathetic nerve fibers, respectively. Read More

Acupunct Med 2022 May 17:9645284221085576. Epub 2022 May 17.

BioMechanical Engineering Laboratory, University Hospital, Federal University of Santa Catarina, Florianópolis, Brazil.

Objectives: This study analyzed the physical-chemical properties of three different brands of acupuncture needle, classified by acupuncturists as high (A), medium (B) and low (C) quality.

Methods: Experienced acupuncturists, rated, in terms of perceived needling quality, three acupuncture needle brands as high (A), medium (B) and low (C) quality. Next, scanning electron microscopy (SEM) images of the tip and surface finish of the needles of each brand were analyzed. Read More

Acupunct Med 2022 May 17:9645284221085279. Epub 2022 May 17.

Department of Acupuncture and Moxibustion Science, Suzuka University of Medical Science, Suzuka, Japan.

Background: GV20 and are important targets in acupuncture treatment for depression. In this study, we examined the antidepressant effects of simultaneous acupuncture stimulation at GV20 and .

Methods: We compared the antidepressant effects of manual acupuncture (MA) stimulation at GV20 and , compared to acupuncture stimulation at two control point locations on the back of the mice (overlying the spinal column) and imipramine administration in a forced swimming (FS)-induced mouse model of depression, and examined the mRNA and protein expression of neurotrophic factors, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-3, and NT-4/5 in the brains by real-time polymerase chain reaction in two different experimental schedules - preventive (MA given alongside FS modelling) and therapeutic (MA given after FS-induced depression was already established). Read More

Acupunct Med 2022 May 17:9645284221085282. Epub 2022 May 17.

School of Health and Biomedical Sciences, College of Science, Technology, Engineering and Mathematics (STEM), RMIT University, Bundoora, VIC, Australia.

Purpose: Level 1 evidence supports the use of acupuncture/acupressure (A/A) to manage post-operative nausea and vomiting (PONV). This study aimed to survey healthcare professionals' attitudes towards A/A, influencing factors and barriers to implementing this effective non-drug intervention into peri-operative care.

Methods: A validated, anonymous survey with 43 questions was emailed or distributed as a hard copy at meetings to anaesthetists, midwives, nurses, obstetricians, gynaecologists and surgeons at a public hospital in Australia. Read More

Dis Markers 2022 7;2022:8099595. Epub 2022 May 7.

Henan University of Chinese Medicine, Zhengzhou Henan, China.

. Cancer-related fatigue (CRF) is a painful, persistent feeling of physical and cognitive subjective fatigue related to cancer or cancer remedy. The occurrence of CRF may be related to the hypothalamic-pituitary-adrenaline (HPA) axis, inflammatory mediator theory, and gut microbiota. Read More

Trials 2022 May 16;23(1):408. Epub 2022 May 16.

Department of Physical Therapy, Federal University of São Carlos (UFSCar), Rodovia Washington Luis, km 235, São Carlos, SP, CEP 13565-905, Brazil.

Background: Nonspecific neck pain is a multifactorial and very common condition in adult individuals, traditional acupuncture (TA) and laser acupuncture (LA) may be treatment options for certain individuals in such a condition. However, no reports were found in the literature comparing the effectiveness of TA and LA in cases of chronic nonspecific neck pain. Therefore, the aim of the present study is to investigate the effectiveness of TA and LA therapies in individuals with chronic nonspecific neck pain, noting which one is more efficient for this condition. Read More

Chin Med 2022 May 17;17(1):57. Epub 2022 May 17.

College of Acupuncture, Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan, China.

Background: Myocardial fibrosis changes the structure of myocardium, leads to cardiac dysfunction and induces arrhythmia and cardiac ischemia, threatening patients' lives. Electroacupuncture at PC6 (Neiguan) was previously found to inhibit myocardial fibrosis. Long non-coding RNAs (lncRNAs) play a variety of regulatory functions in myocardial fibrosis, but whether electroacupuncture can inhibit myocardial fibrosis by regulating lncRNA has rarely been reported. Read More

Int J Chron Obstruct Pulmon Dis 2022 6;17:1107-1120. Epub 2022 May 6.

Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China.

Background: Smoking cessation is recommended as a key intervention for chronic obstructive pulmonary disease (COPD) smokers. However, in China, few COPD smokers quit successfully. The aim of this study was to explore in depth the barriers and facilitators for smoking cessation among smokers with COPD in China. Read More

Front Psychiatry 2022 27;13:799128. Epub 2022 Apr 27.

School of Rehabilitation and Health Preservation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Objective: Internet Addiction Disorder (IAD) has become a social problem. Literature suggests that negative life events can cause numerous problematic behaviors and part of them will result in IAD. However, there is a lack of evidence that elucidates the association between negative life events and IAD. Read More

Front Neurosci 2022 28;16:845737. Epub 2022 Apr 28.

Department of Rehabilitation Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Objective: The objectives of the study were to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) treatment for poststroke dysphagia (PSD) and explore the optimal stimulation parameters.

Method: The databases of Medline, Embase, Web of Science, and Cochrane Library were searched from the establishment to June 2021. All randomized controlled trials about rTMS treatment for PSD were enrolled. Read More

Front Med (Lausanne) 2022 29;9:872362. Epub 2022 Apr 29.

Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Background: Chronic neck pain is a prevalent condition adversely impacting patients' wellbeing in both life and work experience. Electro-thumbtack needle (ETN) therapy, combining acupuncture with transcutaneous stimulation, might be one of the effective complementary and alternative medicine (CAM) therapies in treating chronic neck pain, although the evidence is scarce. This study aims to estimate the efficacy and safety of ETN therapy for chronic neck pain. Read More

Comput Math Methods Med 2022 5;2022:2613901. Epub 2022 May 5.

Outpatient Department, 971st Hospital, People's Liberation Army Navy, Qingdao, Shandong 266071, China.

Objective: To explore the effect of a moxibustion instrument combined with intermediate frequency electrostatic therapy on pain and joint function in elderly patients with cold-dampness arthritis (KOA).

Method: 200 patients with cold-dampness KOA treated in our hospital from May 2019 to September 2021 were selected. According to the random number table method, they were divided into the observation group ( = 100) and control group ( = 100). Read More

Front Hum Neurosci 2022 29;16:851586. Epub 2022 Apr 29.

Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Background: The neural activity of irritable bowel syndrome (IBS) patients in the resting state without any intervention has not been systematically studied. The purpose of this study was to compare the resting-state brain functions of IBS patients with healthy controls (HCs).

Methods: The published neuroimage studies were obtained from electronic databases including PubMed, EMBASE, PsycINFO, Web of Science Core, CNKI Database, Wanfang Database, VIP Database, and CBMdisc. Read More

Scanning 2022 27;2022:7928052. Epub 2022 Apr 27.

Shijiazhuang Maternity and Child Healthcare Hospital, Shijiazhuang, Hebei 050000, China.

In order to explore the clinical point selection rules of acupuncture and moxibustion in the treatment of infantile enuresis based on data mining technology, first, it introduces the principle of data mining technology, the global optimization strategy of information extraction + genetic search. In China Biomedical Literature Database, CNKI, Weipu, Wanfang. Use "enuresis," "enuresis," "leathering," "urinary discharge," "drowning," "bedwetting," "nocturia," "drowning," "moxibustion," "moxibustion," and "moxibustion" as search terms, take (enuresis + enuresis + urination + urination + addiction + bedwetting), (moxibustion + moxibustion + moxibustion)" as the retrieval style. Read More

Front Pharmacol 2022 27;13:909153. Epub 2022 Apr 27.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, China.

Front Public Health 2022 28;10:858587. Epub 2022 Apr 28.

Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Background: Progress has been achieved by using acupuncture widely for poor endometrial receptivity (PER). However, different acupuncture dosages may lead to controversy over efficacy.

Objective: To evaluate the evidence-based conclusions of dose-related acupuncture on infertile women with PER. Read More

Zhonghua Yi Shi Za Zhi 2022 Jan;52(1):12-20

Institute for History of Medicine and Medical Literature,China Academy of Chinese Medical Sciences, Beijing 100700,China.

(Yi Li Han) as the earliest Persian transcription of traditional Chinese medicine for the west, has great value in the history of Sino-Iranian medical cultural exchanges. The eleven drawings attached to concerning meridians and pulse diagnosis were compared to relative paintings attached to some ancient Chinese medical books. It was found that eight of the drawings attached to came from the paintings attached to by Li Jiong. Read More

Reprod Biomed Online 2022 Feb 10. Epub 2022 Feb 10.

UCSF Center for Reproductive Health, University of California, San Francisco CA, USA.

Patients undergoing IVF experience high levels of IVF-related state anxiety. Non-pharmacological interventions such as acupuncture may provide support, but its effect on IVF-related anxiety is unclear. This was a systematic review and meta-analysis to examine the effect of acupuncture on IVF-related state anxiety. Read More

Ind Health 2022 May 13. Epub 2022 May 13.

Department of Acupuncture and Moxibustion, Faculty of Health Care, Teikyo Heisei University, Japan.

To evaluate whetherfinancial aid for acupuncture therapy is beneficial for non-manufacturing jobworkers (office workers) who are aware of reduced job performance due to healthissues (presenteeism), a four-week pragmatic multicenter randomized study was conductedwith office workers who were aware of their presenteeism. The control group onlyimplemented the workplace-recommended presenteeism measures, whereas theintervention group received financial aid for acupuncture therapy of up to 8,000 JPY in addition to implementing the presenteeismmeasures recommended by each workplace. The major outcome measure was the WorldHealth Organization Health and Work Performance Questionnaire relativepresenteeism score. Read More

J Prof Nurs 2022 May-Jun;40:13-19. Epub 2022 Feb 16.

University of Virginia School of Nursing, 225 Jeanette Lancaster Way, Charlottesville, VA 22903, United States of America. Electronic address:

The integrative review (IR) is a methodology of importance to nursing and other disciplines to evaluate and synthesize data from diverse sources to answer research questions, generate new theories, and to provide a comprehensive view of what is known regarding a topic of interest. Current, concise and introductory articles on how to conduct IRs are limited. Although a bias may exist that the IR is less rigorous than other types of literature reviews, the complexity of the search and evaluation of diverse sources increases the need for rigor to produce a well-written IR that advances evidence-based practice (EBP). Read More

Brain Res 2022 May 11;1788:147937. Epub 2022 May 11.

The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China; Department of Neurobiology and Acupuncture Research, Zhejiang Chinese Medical University, Hangzhou, China. Electronic address:

The blood-brain barrier (BBB) is a dynamic structure that protects the brain from harmful blood-borne, endogenous and exogenous substances and maintains the homeostatic microenvironment. All constituent cell types play indispensable roles in the BBB's integrity, and other structural BBB components, such as tight junction proteins, adherens junctions, and junctional proteins, can control the barrier permeability. Regarding the need to exchange nutrients and toxic materials, solute carriers, ATP-binding case families, and ion transporter, as well as transcytosis regulate the influx and efflux transport, while the difference in localisation and expression can contribute to functional differences in transport properties. Read More

Phytomedicine 2022 May 6;102:154149. Epub 2022 May 6.

Department of Clinical Pharmacology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China. Electronic address:

Background: Colorectal cancer (CRC) is an important death-related disease in the world and new therapeutic strategies are urgently needed to reduce mortality. Several studies have demonstrated that emodin, the main ingredient of Rheum palmatum, fights cancer but its potential anti-tumor effect on CRC is still unknown.

Purpose: The present study is aimed to explore the potential anti-tumor effects of emodin against CRC and the underlying molecular mechanism. Read More