1,035,945 results match your criteria Active Learning In Higher Education[Journal]


Systematic characterization of alkaloids in Eomecon chionantha Hance using ultra-high-performance liquid chromatography-tandem quadruple-exactive orbitrap mass spectrometry with a four-step screening strategy.

Rapid Commun Mass Spectrom 2020 Jul 7:e8880. Epub 2020 Jul 7.

Hunan Province Key Laboratory for Antibody-based Drug and Intelligent Delivery System, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua, 418000, China.

Rationale: Eomecon chionantha Hance (ECH), a traditional folk herb, is commonly used to treat traumatic injuries based on its analgesic and anti-inflammatory properties. Previous studies have reported that alkaloids are the major bioactive components in ECH. Therefore, identification of alkaloids from ECH contributes to the discovery of its potential active ingredients and quality control in clinic treatments. Read More

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http://dx.doi.org/10.1002/rcm.8880DOI Listing

Investigating SARS-CoV-2 surface and air contamination in an acute healthcare setting during the peak of the COVID-19 pandemic in London.

Clin Infect Dis 2020 Jul 8. Epub 2020 Jul 8.

Department of Infectious Disease, Imperial College London, London, UK.

Background: Evaluation of SARS-CoV-2 surface and air contamination during the COVID-19 pandemic in London.

Methods: We performed this prospective cross-sectional observational study in a multi-site London hospital. Air and surface samples were collected from seven clinical areas, occupied by patients with COVID-19, and a public area of the hospital. Read More

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http://dx.doi.org/10.1093/cid/ciaa905DOI Listing

Increased protection of earlier use of immunoprophylaxis in preventing perinatal transmission of hepatitis B virus.

Clin Infect Dis 2020 Jul 8. Epub 2020 Jul 8.

Department of Experimental Medicine and Jiangsu Key Laboratory for Molecular Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

Background: Passive-active immunoprophylaxis against mother-to-child transmission (MTCT) of hepatitis B virus (HBV) recommends administer hepatitis B immunoglobulin (HBIG) and birth dose hepatitis B vaccine in infants within 12 or 24 hours after birth. With this protocol, MTCT of HBV still occurs in 5-10% infants of HBV-infected mothers with positive hepatitis B e antigen (HBeAg).

Methods: The present study aimed to investigate whether earlier administration of HBIG and hepatitis B vaccine after birth can further increase the protection efficacy. Read More

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http://dx.doi.org/10.1093/cid/ciaa898DOI Listing

Investigating the origins of ultra-short relaxation times of silver filaments in forming-free SiO2-based conductive bridge memristors.

Nanotechnology 2020 Jul 7. Epub 2020 Jul 7.

Institute of Microelectronics, National Centre for Scientific Research 'Demokritos', Athens, GREECE.

The threshold switching effect is considered of outmost importance for a variety of applications ranging from the reliable operation of crossbar architectures to emulating neuromorphic properties with artificial neural networks. This property is strongly believed to be associated with the rich inherit dynamics of a metallic conductive filament (CF) formation and its respective relaxation processes. Understanding the origin of these dynamics is very important in order to control the degree of volatility and design novel electronic devices. Read More

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http://dx.doi.org/10.1088/1361-6528/aba3a1DOI Listing

A detailed in silico analysis of the amylolytic family GH126 and its possible relatedness to family GH76.

Carbohydr Res 2020 Jun 23;494:108082. Epub 2020 Jun 23.

Laboratory of Protein Evolution, Institute of Molecular Biology, Slovak Academy of Sciences, SK-84551, Bratislava, Slovakia; Department of Biology, Faculty of Natural Sciences, University of SS. Cyril and Methodius, SK-91701, Trnava, Slovakia. Electronic address:

The glycoside hydrolase (GH) family 126 was established based on the X-ray structure determination of the amylolytic enzyme CPF_2247 from Clostridium perfringens genome. Its original identification as a putative carbohydrate-active enzyme was based on its low, yet significant sequence identity to members of the family GH8, which are inverting endo-β-1,4-glucanases. As the family GH8 forms the clan GH-M with GH48, the CPF_2247 protein also exhibits similarities with members of the family GH48. Read More

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http://dx.doi.org/10.1016/j.carres.2020.108082DOI Listing

Application of Artificial Intelligence in COVID-19 drug repurposing.

Diabetes Metab Syndr 2020 Jul 3;14(5):1027-1031. Epub 2020 Jul 3.

School of Electronics Engineering, KIIT University, Bhubaneswar, Odisha, India. Electronic address:

Background And Aim: COVID-19 outbreak has created havoc and a quick cure for the disease will be a therapeutic medicine that has usage history in patients to resolve the current pandemic. With technological advancements in Artificial Intelligence (AI) coupled with increased computational power, the AI-empowered drug repurposing can prove beneficial in the COVID-19 scenario.

Methods: The recent literature is studied and analyzed from various sources such as Scopus, Google Scholar, PubMed, and IEEE Xplore databases. Read More

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http://dx.doi.org/10.1016/j.dsx.2020.06.068DOI Listing

Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse.

Ecotoxicol Environ Saf 2020 Jul 4;202:110902. Epub 2020 Jul 4.

Health Protection Research Unit, Wolfson Building, Newcastle University, Newcastle Upon Tyne, NE2 4AA, United Kingdom; Institute Translational and Clinical Research, Level 4 Leech, Newcastle University, Newcastle Upon Tyne, NE2 4HH, United Kingdom. Electronic address:

The ionic liquid 1-octyl-3-methylimidazolium (M8OI) has been found in the environment and identified as a hazard for triggering the liver disease primary biliary cholangitis (PBC). Given limited toxicity data for M8OI and other structurally-related ionic liquids, target organs for M8OI toxicity were examined. Adult male C57Bl6 mice were acutely exposed to 0-10 mg/kg body weight M8OI via 2 intraperitoneal injections (time zero and 18 h) and effects examined at 24 h. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110902DOI Listing

Advances in menaquinone biosynthesis: sublocalisation and allosteric regulation.

Curr Opin Struct Biol 2020 Jul 4;65:33-41. Epub 2020 Jul 4.

Laboratory of Structural Biology, School of Biological Sciences and Maurice Wilkins Centre for MolecularBiodiscovery, University of Auckland, Private Bag 92019, Auckland, New Zealand.

Menaquinones (vitamin K2) are a family of redox-active small molecules with critical functions across all domains of life, including energy generation in bacteria and bone health in humans. The enzymes involved in menaquinone biosynthesis also have bioengineering applications and are potential antimicrobial drug targets. New insights into the essential roles of menaquinones, and their potential to cause redox-related toxicity, have highlighted the need for this pathway to be tightly controlled. Read More

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http://dx.doi.org/10.1016/j.sbi.2020.05.005DOI Listing

To move or not to move: roles and specificity of plant RNA mobility.

Curr Opin Plant Biol 2020 Jul 4;57:52-60. Epub 2020 Jul 4.

Institute for Molecular Physiology (imP), University of Mainz, Johannes von Müller-Weg 6, 55128 Mainz, Germany.

Intercellular communication in plants coordinates cellular functions during growth and development, and in response to environmental cues. RNAs figure prominently among the mobile signaling molecules used. Many hundreds of RNA species move over short and long distances, and can be mutually exchanged in biotic interactions. Read More

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http://dx.doi.org/10.1016/j.pbi.2020.05.005DOI Listing

Impact of maternal physical activity during an uncomplicated pregnancy on fetal and neonatal well-being parameters: a systematic review of the literature.

Eur J Obstet Gynecol Reprod Biol 2020 Jun 29;252:265-272. Epub 2020 Jun 29.

Obstetric Research Lab, Women-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland.

We carried a thorough systematic review of the contemporary literature regarding the impact of maternal physical activity during pregnancy on the fetal and neonatal well-being parameters. We searched systematically publications indexed in PubMed and ScienceDirect, according to the PRISMA protocol. Studies examining following fetal and neonatal well-being parameters were included: fetal heart rate, active fetal movements, Doppler assessment of the placental and fetal circulations, amniotic fluid index, Apgar score, and umbilical cord blood acid-basis analysis at delivery. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.06.061DOI Listing

Synthesis, characterization, antimicrobial and cytotoxic activity of novel half-sandwich Ru(II) arene complexes with benzoylthiourea derivatives.

J Inorg Biochem 2020 Jun 26;210:111164. Epub 2020 Jun 26.

Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, Serbia. Electronic address:

Three new ruthenium(II)-arene complexes, [Ru(η-p-cymene)(L)Cl] (C1) where L is N-((4 methoxyphenyl)carbamothioyl)benzamide; [Ru(η-p-cymene)(L)Cl] (C2) where L is 4-(3-benzoylthioureido)benzoic acid and [Ru(η-p-cymene)(L)Cl] (C3) where L is methyl 4-(3- benzoylthioureido)benzoate have been synthetized, characterized and evaluated for their antimicrobial and anticancer activity. Characterization was performed using H and C NMR, IR spectroscopy, mass spectrometry, electrical conductivity measurements and X-Ray diffraction analysis. X-Ray diffraction analysis of C1 showed typical expected "piano-stool" geometry with ruthenium coordinated to ligand via nitrogen and sulfur atoms of benzoylthiourea derivatives. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2020.111164DOI Listing

Trastuzumab emtansine (T-DM1) in patients with HER2-positive metastatic breast cancer and brain metastases: exploratory final analysis of cohort 1 from KAMILLA, a single-arm phase IIIb clinical trial.

Ann Oncol 2020 Jul 4. Epub 2020 Jul 4.

Department of Medical Oncology, Guy's Hospital and Sarah Cannon Research Institute, London, UK.

Background: Patients with brain metastases (BM) from human epidermal growth factor receptor 2 (HER2)-positive breast cancer represent a difficult-to-treat population. Trastuzumab emtansine (T-DM1) has shown potential activity in this subset of patients in small clinical series.

Patients And Methods: KAMILLA is an ongoing, phase IIIb study of T-DM1 in patients with HER2-positive locally advanced/metastatic breast cancer (MBC) with prior HER2-targeted therapy and chemotherapy. Read More

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http://dx.doi.org/10.1016/j.annonc.2020.06.020DOI Listing

A phase II, multicenter, two cohort study of 160 mg osimertinib in EGFR T790M-positive non-small cell lung cancer patients with brain metastases or leptomeningeal disease who progressed on prior EGFR TKI therapy.

Ann Oncol 2020 Jul 4. Epub 2020 Jul 4.

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Electronic address:

Background: Up to 40% of patients with non-small cell lung cancer (NSCLC) and EGFR mutations treated with EGFR tyrosine kinase inhibitors (TKIs) present with disease progression in the central nerve system (CNS), either as brain metastases (BM) or leptomeningeal metastases (LM). Osimertinib (80mg), a third generation, irreversible, oral EGFR TKI, has shown efficacy in active CNS metastases. However, efficacy of 160mg osimertinib in BM or LM is unclear. Read More

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http://dx.doi.org/10.1016/j.annonc.2020.06.017DOI Listing

Results from the Netherlands' 2018 Report Card and Report Card on physical activity for children and youth with and without chronic medical condition.

Public Health 2020 Jul 4;185:161-166. Epub 2020 Jul 4.

Dutch National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

Objective: The objective of this study was to summarize the results of the 2018 the Netherlands' Physical Activity Report Card (PARC) for children and youth as well as for children and youth with a chronic medical condition (CMC; PARC).

Study Design: This study is a survey.

Methods: A total of 12 indicators were graded using the Active Healthy Kids Global Alliance PARC development process, which includes a synthesis of the best available research, surveillance, policy and practice findings and expert consensus. Read More

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http://dx.doi.org/10.1016/j.puhe.2020.04.044DOI Listing

Heterologous expression of lytic polysaccharide monooxygenases (LPMOs). A mini-review.

Biotechnol Adv 2020 Jul 4:107583. Epub 2020 Jul 4.

Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås 1430, Norway. Electronic address:

Lytic polysaccharide monooxygenases (LPMOs) are relatively new enzymes that have been discovered 10 years ago. LPMOs comprise a diverse group of enzymes which play a pivotal role in the depolymerization of sugar-based biopolymers including cellulose, hemicellulose, chitin, and starch. Their mechanism of action relies on the correct coordination of a copper ion in the active site, which is partly composed of the N-terminal histidine. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2020.107583DOI Listing

A panel of circulating long non-coding RNAs as liquid biopsy biomarkers for breast and cervical cancers.

Biochimie 2020 Jul 4. Epub 2020 Jul 4.

Department of Zoology, Central University of Punjab, Bathinda, Punjab, India. Electronic address:

The early detection and diagnosis of cancer is critical to optimize the treatment and management of cancer patients. Typical methods such as imaging and tissue biopsy are invasive, time-consuming, and often imprecise. Thus, recent technological advances of dependable, facile, and minimally invasive collectible oncogenic biomarkers using human biofluids and secretions have been an active area of research. Read More

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http://dx.doi.org/10.1016/j.biochi.2020.06.012DOI Listing

Multimodal Theranostics Augmented by Transmembrane Polymer-Sealed Nano-enzymatic Porous MoS Nanoflowers.

Int J Pharm 2020 Jul 4:119606. Epub 2020 Jul 4.

Minhang Hospital and School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai 201203, China. Electronic address:

Developing an all-in-one multimodal theranostic platform that can synergistically integrate sensitive photoacoustic (PA) imaging, enhanced photothermal therapy (PTT) and photodynamic therapy (PDT) as well as the nano-enzyme activated chemodynamic therapy (CDT) presents a great challenge for the current nanomedicine design. Herein, a simple hydrothermal method was used to prepare porous molybdenum disulfide (MoS) nanoflowers. These nanoflowers were assembled by three dimensional (3D)-stacked MoS nanosheets with plentiful pores and large surfaces, which thus exhibited enhanced photothermal conversion via light trapping and peroxidase (POD)-like activity via active defects exposure. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119606DOI Listing

Development of in situ gel containing asiaticoside/cyclodextrin complexes. Evaluation in culture human periodontal ligament cells (HPLDCs).

Int J Pharm 2020 Jul 4:119589. Epub 2020 Jul 4.

Faculty of Pharmaceutical Sciences, Chulalongkorn University, 254 Phyathai rd., Pathumwan, Bangkok, 10330, Thailand. Electronic address:

Asiaticoside (AS), an active herbal compound isolated from Centella asiatica, has the potential benefit in promoting type I collagen (COL I) synthesis and osteogenic differentiation in human periodontal ligament cells (HPDLCs). However, it has low aqueous solubility which may hamper the bioavailability. Thus, the aim of this study was to develop thermoresponsive in situ gel containing AS/cyclodextrin (CD) complexes. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119589DOI Listing

Autophagy in the crosstalk between tumor and microenvironment.

Cancer Lett 2020 Jul 4. Epub 2020 Jul 4.

UMR E-4320 TIRO-MATOs CEA/DRF/Institut des sciences du vivant Frédéric Joliot, Université Côte d'Azur, Faculté de Médecine, Nice, France. Electronic address:

Autophagy is the major catabolic process in eukaryotic cells for the degradation and recycling of damaged macromolecules and organelles. It plays a crucial role in cell quality control and nutrient supply under stress conditions. Although autophagy is classically described as a degradative mechanism, it can also be involved in some secretion pathways, leading to the extracellular release of proteins, aggregates, or organelles. Read More

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http://dx.doi.org/10.1016/j.canlet.2020.06.015DOI Listing

Modulation of LPS-induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor.

Eur J Pharmacol 2020 Jul 4:173340. Epub 2020 Jul 4.

Department of Chemical and Biomolecular Engineering, Ohio University, Athens, OH, 45701, USA; Biomedical Engineering Program, Ohio University, Athens, OH, 45701, USA. Electronic address:

Sepsis is a serious condition that can lead to long-term organ damage and death. At the molecular level, the hallmark of sepsis is the elevated expression of a multitude of potent cytokines, i.e. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173340DOI Listing

Therapeutic effects of triptolide from Tripterygium wilfordii Hook. f. on interleukin-1-beta-induced osteoarthritis in rats.

Eur J Pharmacol 2020 Jul 4:173341. Epub 2020 Jul 4.

Department of Orthopedics, Tianjin Hospital, Tianjin, 300211, China. Electronic address:

Osteoarthritis (OA) is a common yet destructive disease affecting the articular cartilage, and is a major cause of immense suffering and disability for millions of people. Previous studies have shown that triptolide (TPL), an active compound derived from Tripterygium wilfordii, has potent immunosuppressive and anti-inflammatory activities useful for treating chronic diseases. However, whether TPL has immunosuppressive activity against OA is not known. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173341DOI Listing

Evaluation of the neuroprotective potential of caffeic acid phenethyl ester in a cellular model of Parkinson's disease.

Eur J Pharmacol 2020 Jul 4:173342. Epub 2020 Jul 4.

Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University, 26 Ağustos Campus, Kayisdagi cad., Kayisdagi, TR-34755, Istanbul, Turkey. Electronic address:

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, and oxidative stress and mitochondrial dysfunction play a major role in the pathogenesis of PD. Since conventional therapeutics are not sufficient for the treatment of PD, the development of new agents with anti-oxidant potential is crucial. Caffeic Acid Phenethyl Ester (CAPE), a biologically active flavonoid of propolis, possesses several biological properties such as immunomodulatory, anti-inflammatory and anti-oxidative. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173342DOI Listing

Roles of selenoprotein T and transglutaminase in active immunization against entomopathogenic fungi in the termite Reticulitermes chinensis.

J Insect Physiol 2020 Jul 4:104085. Epub 2020 Jul 4.

Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, Huazhong Agricultural University, Wuhan 430070, Hubei, China. Electronic address:

Active immunization can protect individuals from infectious diseases in social insects. It is well established that trace elements are essential to the host immune system, but the related gene functions in insect social immunity are unknown. Here, we found that the levels of three free elements (Se, Ca and Cr) and selenoprotein T (SELT) expression were significantly decreased in the termite Reticulitermes chinensis Snyder during active immunization against the entomopathogenic fungus Metarhizium anisopliae (Metchnikoff) Sorokin. Read More

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http://dx.doi.org/10.1016/j.jinsphys.2020.104085DOI Listing

Neural Tube Defects and Associated Anomalies Before and After Folic Acid Fortification.

J Pediatr 2020 Jul 4. Epub 2020 Jul 4.

Greenwood Genetic Center, Greenwood, South Carolina, USA. Electronic address:

Objective: To examine the prevalence and types of neural tube defects and the types of anomalies co-occurring with neural tube defects in six years before fortification of cereal grain flour with folic acid (1992-1998) and 20 years after fortification (1999-2018) in South Carolina, a state with a historically high prevalence of these birth defects.

Study Design: The prevalence of neural tube defects was determined by active and passive surveillance methods in South Carolina since 1992. The types of neural tube defects and co-occurring malformations were determined by prenatal ultrasound and post-delivery examination. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.07.002DOI Listing

A Two-Component System Acquired by Horizontal Gene Transfer Modulates Gene Transfer and Motility Via Cyclic Dimeric GMP.

J Mol Biol 2020 Jul 4. Epub 2020 Jul 4.

Department of Biology, Memorial University of Newfoundland, St. John's, NL, A1B 3X9, Canada. Electronic address:

Bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) is an important intracellular signaling molecule that affects diverse physiological processes in bacteria. The intracellular levels of c-di-GMP are controlled by proteins acting as diguanylate cyclase (DGC) and phosphodiesterase (PDE) enzymes that synthesize and degrade c-di-GMP, respectively. In the alphaproteobacterium Rhodobacter capsulatus, flagellar motility and gene exchange via production of the gene transfer agent RcGTA are regulated by c-di-GMP. Read More

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http://dx.doi.org/10.1016/j.jmb.2020.07.001DOI Listing

Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design.

Cell 2020 Jun 27. Epub 2020 Jun 27.

Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address:

Heterotrimeric G-proteins (Gαβγ) are the main transducers of signals from GPCRs, mediating the action of countless natural stimuli and therapeutic agents. However, there are currently no robust approaches to directly measure the activity of endogenous G-proteins in cells. Here, we describe a suite of optical biosensors that detect endogenous active G-proteins with sub-second resolution in live cells. Read More

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http://dx.doi.org/10.1016/j.cell.2020.06.020DOI Listing

Trapping of swimming microalgae in foam.

J R Soc Interface 2020 Jul 8;17(168):20200077. Epub 2020 Jul 8.

Université de Paris, CNRS UMR 7057, Laboratoire Matière et Systèmes Complexes MSC, F-75006 Paris, France.

Massive foam formation in aquatic environments is a seasonal event that has a significant impact on the stability of marine ecosystems. Liquid foams are known to filter passive solid particles, with large particles remaining trapped by confinement in the network of liquid channels and small particles being freely advected by the gravity-driven flow. By contrast, the potential role of a similar retention effect on biologically active particles such as phytoplankton cells is still relatively unknown. Read More

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http://dx.doi.org/10.1098/rsif.2020.0077DOI Listing

Oxygen-Based Anion Redox for Lithium Batteries.

Acc Chem Res 2020 Jul 7. Epub 2020 Jul 7.

Chemical Sciences and Engineering Division, Argonne National Laboratory, 9700 Cass Ave, Lemont, Illinois 60439, United States.

ConspectusThe importance of current Li-ion batteries (LIBs) in modern society cannot be overstated. While the energy demands of devices increase, the corresponding enhancements in energy density of battery technologies are highly sought after. Currently, many different battery concepts, such as Li-S and metal-air among many others, have been investigated. Read More

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http://dx.doi.org/10.1021/acs.accounts.0c00104DOI Listing

PTEN and ERG expression in MRI-ultrasound guided fusion biopsy correlated with radical prostatectomy findings in men with prostate cancer.

Prostate 2020 Jul 7. Epub 2020 Jul 7.

Department of Pathology (HUS Diagnostic Center) and Medicum, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: Conventional systematic prostate biopsies (SBx) have multiple limitations, and magnetic resonance imaging (MRI)-ultrasound fusion targeting is increasingly applied (fusion biopsies [FBx]). In our previous studies, we have shown that loss of the tumor suppressor gene phosphatase and tensin homolog (PTEN) in radical prostatectomy (RP) specimens predicts poor disease-specific survival, and in active surveillance (AS), PTEN loss in SBx predicts an adverse AS outcome, although SBx PTEN status does not correlate well with the corresponding RP status. Here, we have hypothesized that PTEN and erythroblast transformation-specific related gene (ERG) status in FBx correlate better with RP than they would in SBx. Read More

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http://dx.doi.org/10.1002/pros.24040DOI Listing

Trivalent Rare-earth Metal Amide Complexes as Catalysts for Hydrosilylation of Benzophenone Derivatives with HN(SiHMe2)2 via Amine Exchange Reaction.

Chemistry 2020 Jul 7. Epub 2020 Jul 7.

Osaka University, Graduate School of Engineering Science, 1-3, Machikaneyama-cho, 560-8531, Toyonaka, JAPAN.

The rare-earth metal complexes Ln( L 1 )[N(SiHMe 2 ) 2 ](thf) (Ln = La, Ce, Y; L 1 = N , N'' -bis(pentafluorophenyl)diethylenetriamine dianion) were synthesized by treating Ln[N(SiHMe 2 ) 2 ] 3 (thf) 2 with L 1 H 2 . The lanthanum and cerium derivatives are active catalysts for the hydrosilylation of benzophenone derivatives with HN(SiHMe 2 ) 2 . An amine exchange reaction was revealed as a key step of the catalytic cycle, where Ln---Si-H β-agostic interactions are proposed to promote insertion of the carbonyl moiety into the Si-H bond. Read More

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http://dx.doi.org/10.1002/chem.202002011DOI Listing

MicroRNAs as Key Regulators of Ovarian Cancers.

Cell Med 2019 6;11:2155179019873849. Epub 2019 Sep 6.

Department of Zoology, University of Delhi, Delhi, India.

The tumor microenvironment can be realistically viewed as an active battle ground between the host immune system and the growing tumor cells. This reactive space surrounding the tumor possesses several possibilities and facilitates the progression of a tumor from a neoplastic stage to that of metastasis. The contemporary approach of understanding the cancer biology from a "within the cell" perspective has been largely challenged with complex and intricate "outside the cell" events. Read More

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http://dx.doi.org/10.1177/2155179019873849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732848PMC
September 2019

Integration of molecular networking and fingerprint analysis for studying constituents in Microctis Folium.

PLoS One 2020 7;15(7):e0235533. Epub 2020 Jul 7.

Guangdong Engineering & Technology Research Center for Quality and Efficacy Reevaluation of Post-Market Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.

Microctis Folium is the dried leaves of a plant (Microcos paniculata L.) used to improve the digestive system, alleviate diarrhoea, and relieve fever, but information regarding its chemical composition has rarely been reported. The traditional research approach of determining chemical composition has included isolating, purifying, and identifying compounds with high-cost and time-consuming processes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235533PLOS

The extravasation of contrast as a predictor of cerebral hemorrhagic contusion expansion, poor neurological outcome and mortality after traumatic brain injury: A systematic review and meta-analysis.

PLoS One 2020 7;15(7):e0235561. Epub 2020 Jul 7.

Department of Neuroradiology, Hospital Universitário Cassiano Antônio de Moraes da Universidade Federal do Espírito Santo - HUCAM/UFES/EBSERH, Vitória, State of Espírito Santo, Brazil.

Background: The active extravasation of contrast on CT angiography (CTA) in primary intracerebral hemorrhages (ICH) is recognized as a predictive factor for ICH expansion, unfavorable outcomes and mortality. However, few studies have been conducted on the setting of traumatic brain injury (TBI).

Purpose: To perform a literature systematic review and meta-analysis of the association of contrast extravasation on cerebral hemorrhagic contusion expansion, neurological outcomes and mortality. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235561PLOS

Biopharmaceutics and Pharmacokinetics of Timosaponin A-III by a Sensitive HPLC-MS/MS Method: Low Bioavailability Resulting from Poor Permeability and Solubility.

Curr Pharm Biotechnol 2020 Jul 7. Epub 2020 Jul 7.

Department of Pharmacy, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433. China.

Background: Timosaponin A-III is one of the most promising active saponins from Anemarrhena asphodeloides Bge. As an oral chemotherapeutic agent, there is an urgent need to clarify its biopharmaceutics and pharmacokinetics to improve its development potential.

Objective: This research explores the bioavailability of timosaponin A-III and clarifies its absorption and metabolism mechanisms by a sensitive and specific HPLC-MS/MS method. Read More

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http://dx.doi.org/10.2174/1389201021666200707134045DOI Listing

Disulfide bond-responsive nanotherapeutic systems for effective payload in cancer therapy.

Curr Pharm Des 2020 Jul 7. Epub 2020 Jul 7.

Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM'S NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai. India.

Background: The progressive treatment of cancer using disulfide bond-based therapeutics offer improvement in therapeutic potency of active, reduction in adverse events, prolongation of drug release pattern and on-site action by interacting with neoplastic cell microenvironment.

Objective: The objective of this article is to highlight the research carried out on disulfide bond-based drug delivery systems as a potential candidate for cancer treatment.

Methods: The article provides an overview on the importance of disulfide bonds in cancer treatment in terms of their properties, mechanism or formation/fragmentation and applications. Read More

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http://dx.doi.org/10.2174/1381612826666200707131006DOI Listing

Student midwives' knowledge, skills and competency in relation to the active management of the third stage of labour: A correlational study.

Curationis 2020 Jun 15;43(1):e1-e8. Epub 2020 Jun 15.

Department of Nursing, Faculty of Community Health Sciences, University of the Western Cape, Cape Town.

Background: Lesotho has been experiencing health challenges as indicated by its high maternal mortality ratio of 620 per 100 000 live births for the year 2010, which has been linked to its limited human resources.

Objectives: The knowledge and skills of final-year student nurse-midwives related to the active management of the third stage of labour were determined.

Method: A quantitative, descriptive survey design was used to conduct this study with 99 final-year midwifery students at four nursing schools in Lesotho using stratified sampling. Read More

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http://dx.doi.org/10.4102/curationis.v43i1.2054DOI Listing

Functional metal oxide ink systems for drop-on-demand printed thin film transistors.

Langmuir 2020 Jul 7. Epub 2020 Jul 7.

Drop-on-demand printing is a non-contact, directing patterning and rapid manufacturing printing technology which shows considerable potential in future display manufacturing. Metal oxide is one of the most important kinds of functional materials in thin film transistors which are the core component of active matrix display technology, thus printing high quality metal oxide functional layer is of great importance. In this paper, we focused on the current progress on one of the foundations of drop-on-demand printing technology-the ink system. Read More

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http://dx.doi.org/10.1021/acs.langmuir.0c00835DOI Listing

CuO@CoFe Layered Double Hydroxide Core-Shell Heterostructure as an Efficient Water Oxidation Electrocatalyst under Mild Alkaline Conditions.

Inorg Chem 2020 Jul 7. Epub 2020 Jul 7.

Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China.

Designing hierarchical electrocatalysts with superior water oxidation performance is highly desirable for the production of renewable chemical fuels. Here, we report the development of a CuO@CoFe layered double hydroxide core-shell heterostructure supported on Cu foil (CuO@CoFe-LDH/CF) as a highly active catalyst electrode for water oxidation under mild alkaline conditions. In a 0. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.0c01927DOI Listing

Enantio- and Site-selective α-Fluorination of N-Acyl-3,5-dimethylpyrazoles Catalyzed by Chiral π-Cu(II) Complexes.

Angew Chem Int Ed Engl 2020 Jul 7. Epub 2020 Jul 7.

Nagoya Daigaku, Graduate School of Engineering, JAPAN.

Catalytic enantioselective α-fluorination reactions of carbonyl compounds are among the most powerful and efficient synthetic methods for constructing optically active α-fluorinated carbonyl compounds.   Nevertheless, α-fluorination of α-nonbranched carboxylic acid derivatives is still a big challenge because of relatively high p K a values of their α-hydrogen atoms and difficulty of subsequent synthetic transformation without epimerization.   Here we show that chiral Cu(II)-3-(2-naphthyl)- L -alanine-derived amide complexes are highly effective catalysts for the enantio- and site-selective α-fluorination of N -( α-arylacetyl)- and N -( α-alkylacetyl)-3,5-dimethylpyrazoles. Read More

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http://dx.doi.org/10.1002/anie.202007403DOI Listing

Catalytic Nanoframes and Beyond.

Adv Mater 2020 Jul 7:e2001345. Epub 2020 Jul 7.

Department of Chemistry and Research Institute for Natural Sciences, Korea University, Seoul, 02841, Republic of Korea.

The ever-increasing need for the production and expenditure of sustainable energy is a result of the astonishing rate of consumption of fossil fuels and the accompanying environmental problems. Emphasis is being directed to the generation of sustainable energy by the fuel cell and water splitting technologies. Accordingly, the development of highly efficient electrocatalysts has attracted significant interest, as the fuel cell and water splitting technologies are critically dependent on their performance. Read More

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http://dx.doi.org/10.1002/adma.202001345DOI Listing

Theoretical Study on Photoisomerization Mechanisms of Diphenyl Substituted N,C-chelate Organoboron Compounds.

Chemistry 2020 Jul 7. Epub 2020 Jul 7.

Beijing Institute of Technology, School of Chemistry and Chemical Engineering, CHINA.

N, C-chelate organoboron compounds are widely employed as photo-responsive and optoelectronic materials due to their efficient photochromic reactivity. It was found in experiments that two diphenyl substituted organoboron compounds, B(ppy)Ph 2 (ppy=2-phenylpyridyl) and B(iba)Ph 2 (iba=N-isopropyl-benzylidene-amine), display distinct photochemical reactivity. B(ppy)Ph 2 is inert upon irradiation while B(iba)Ph 2 undergoes photo-induced transformations, yielding BN-cyclohepta-1,3,5-triene via a borirane intermediate. Read More

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http://dx.doi.org/10.1002/chem.202002529DOI Listing

An update on origin of SARS-CoV-2: Despite closest identity, bat (RaTG13) and Pangolin derived Coronaviruses varied in the critical binding site and O-linked glycan residues.

J Med Virol 2020 Jul 7. Epub 2020 Jul 7.

Department of General Medicine, Sri Muthukumaran Medical College Hospital and Research Institute, Affiliated to The Tamil Nadu Dr. M.G.R. Medical University, Chikkarayapuram, Chennai, 600069, India.

The initial cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) occurred in Wuhan, China, in December 2019 and swept the world by 23 June 2020 with 8,993,659 active cases, 469,587 deaths across 216 countries, areas or territories. This strongly implies global transmission occurred before the lockdown of China. However, the initial source's transmission routes of SARS-CoV-2 remain obscure and controversial. Read More

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http://dx.doi.org/10.1002/jmv.26261DOI Listing

The Patterns and Associated Cost of Serologic Testing for Helicobacter pylori in the U.S. Military Health System.

Mil Med 2020 Jul 7. Epub 2020 Jul 7.

Gastroenterology Service, Department of Internal Medicine, WRNMMC, Department of Medicine, Uniformed Services University of the Health Sciences, 8901 Rockville Pike, Bethesda, MD 20889.

Introduction: Helicobacter pylori (H. pylori) infection affects about half of the world's population and can lead to multiple complications if left untreated. Testing for H. Read More

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http://dx.doi.org/10.1093/milmed/usaa141DOI Listing

Foot Muscle Strengthening and Lower Limb Injury Prevention.

Res Q Exerc Sport 2020 Jul 7:1-8. Epub 2020 Jul 7.

Massey University.

: The active and passive structures of the foot act in unison to not only be compliant enough to assist in ground reaction force attenuation but also resist deformation to provide a stable base of support. A foot that is unable to adjust to the imposed demands during high-intensity sporting activities may alter the moments and forces acting on the joints, increasing the risk of non-contact anterior cruciate ligament ruptures (ACLR) and lateral ankle sprains (LAS). Prophylactic strengthening programs are often used to reduce the risk of these injuries, but at present, very few prophylactic programs include foot-specific strengthening strategies. Read More

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http://dx.doi.org/10.1080/02701367.2020.1739605DOI Listing

Resistance of a novel ceramic acetabular cup to critical impact loads.

Proc Inst Mech Eng H 2020 Jul 7:954411920941383. Epub 2020 Jul 7.

MatOrtho Limited, Leatherhead, UK.

A novel thin-walled direct-to-bone fixation ceramic cup was tested under critical impact loads simulating lateral fall and car crash scenarios. Three sizes of BIOLOX delta ceramic cups (total hip replacement cup with bearing diameter of 32 mm and two hip resurfacing cups with bearing diameters of 40 and 64mm) were implanted into reamed Sawbones blocks representing acetabulae. Three cups of each size were fully supported by the block and three were implanted with 15° of the cup's outer diameter unsupported by the block. Read More

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http://dx.doi.org/10.1177/0954411920941383DOI Listing

analysis of Calcium Dependent Protein Kinase 6 of Cr through molecular modeling, docking, and dynamics simulation study.

J Biomol Struct Dyn 2020 Jul 7:1-10. Epub 2020 Jul 7.

School of Biotechnology, KIIT Deemed to be University, Bhubaneswar, Odisha, India.

Calcium Dependent Protein Kinases are found in the Apicomplexan, algae, and plants; however, they are reported in vertebrates and are regarded as excellent drug targets for pharmaceutical interventions. Calcium Dependent Protein Kinases of are probably involved in the regulation of invasion and egress process during the infection of the host cells. The previous study reported that after the Calcium Dependent Protein Kinase 1 gene, Calcium Dependent Protein Kinase 6 of is expressed in all stages of the parasite (merozoites/schizonts as well as sexual stages) at a comparable level and makes it as a valid drug target. Read More

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http://dx.doi.org/10.1080/07391102.2020.1790036DOI Listing

Pilot randomized active-placebo-controlled trial of low-dose ketamine for the treatment of multiple sclerosis-related fatigue.

Mult Scler 2020 Jul 7:1352458520936226. Epub 2020 Jul 7.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: Fatigue is the most common symptom of MS and has no effective pharmacotherapy.

Objective: To determine the tolerability, safety, and efficacy of low-dose ketamine infusion for MS-related fatigue.

Methods: In this double-blind, randomized, active-placebo-controlled trial, 18 subjects with multiple sclerosis (MS) and reported fatigue received a single intravenous infusion of ketamine (0. Read More

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http://dx.doi.org/10.1177/1352458520936226DOI Listing

Non-Dietary Factors Associated with Glycemic Status among Adults Diagnosed with Type 2 Diabetes Mellitus in Malawi.

Soc Work Public Health 2020 Jul 7:1-12. Epub 2020 Jul 7.

Department of Food Science and Human Nutrition, Michigan State University , East Lansing, Michigan, USA.

We assessed glycemic status and associations with socio-demographic, biomedical, anthropometric, and physical activity (PA) levels among adults with type 2 diabetes mellitus (T2DM) (n = 428; urban n = 288; semi-urban n = 140) using a cross-sectional study. Multivariate linear regression was used to determine factors associated with glycosylated hemoglobin (A1C) . A1C was clinically elevated ≥8% for 60. Read More

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http://dx.doi.org/10.1080/19371918.2020.1785367DOI Listing

What does first-line therapy mean for paediatric multiple sclerosis in the current era?

Mult Scler 2020 Jul 7:1352458520937644. Epub 2020 Jul 7.

Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, University College London, London, UK/NIHR UCLH Biomedical Research Centre, London, UK.

Paediatric multiple sclerosis (MS) is associated with higher relapse rate, rapid magnetic resonance imaging lesion accrual early in the disease course and worse cognitive outcome and physical disability in the long term compared to adult-onset disease. Current treatment strategies are largely centre-specific and reliant on adult protocols. The aim of this review is to examine which treatment options should be considered first line for paediatric MS and we attempt to answer the question if injectable first-line disease-modifying therapies (DMTs) are still an optimal option. Read More

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http://dx.doi.org/10.1177/1352458520937644DOI Listing

Exploring the In Vivo and In Vitro Anticancer Activity of Rhenium Isonitrile Complexes.

Inorg Chem 2020 Jul 7. Epub 2020 Jul 7.

Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.

The established platinum-based drugs form covalent DNA adducts to elicit their cytotoxic response. Although they are widely employed, these agents cause toxic side-effects and are susceptible to cancer-resistance mechanisms. To overcome these limitations, alternative metal complexes containing the rhenium(I) tricarbonyl core have been explored as anticancer agents. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.0c01442DOI Listing
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