970,408 results match your criteria Active Learning In Higher Education[Journal]


Impact of Deployment on Reproductive Health in U.S. Active-Duty Servicewomen and Veterans.

Semin Reprod Med 2018 Nov 19;36(6):361-370. Epub 2019 Apr 19.

Informatics, Decision Enhancement, and Analytic Sciences (IDEAS) Center, VA Salt Lake City Health Care System, Salt Lake City, Utah.

Reproductive-age women are a fast-growing component of active-duty military personnel who experience deployment and combat more frequently than previous service-era women Veterans. With the expansion of the number of women and their roles, the United States Departments of Defense and Veterans Affairs have prioritized development and integration of reproductive services into their health systems. Thus, understanding associations between deployments or combat exposures and short- or long-term adverse reproductive health outcomes is imperative for policy and programmatic development. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678749
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http://dx.doi.org/10.1055/s-0039-1678749DOI Listing
November 2018
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The Department of Defense Birth and Infant Health Research Program: Assessing the Reproductive Health of U.S. Active-Duty Women.

Semin Reprod Med 2018 Nov 19;36(6):351-360. Epub 2019 Apr 19.

The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland.

As the percentage of women serving in the active-duty military continues to grow, and as their roles continue to expand, the importance of monitoring reproductive health in the military community increases. The Department of Defense Birth and Infant Health Research (BIHR) program conducts ongoing epidemiologic studies to assess potential increased risks for adverse reproductive and infant health outcomes in the military population. Military personnel endure unique physical and mental demands as a part of their occupational duties (e. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678751
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http://dx.doi.org/10.1055/s-0039-1678751DOI Listing
November 2018
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The Gynecologic Health Consequences of Chlamydia trachomatis Infection in Military Servicewomen.

Semin Reprod Med 2018 Nov 19;36(6):340-350. Epub 2019 Apr 19.

Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, Washington.

is the most common sexually transmitted bacterial infection in the United States. Within the U.S. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678752
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http://dx.doi.org/10.1055/s-0039-1678752DOI Listing
November 2018
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Assisted Reproductive Technology and the Reproductive Endocrinology and Infertility Specialist in the U.S. Military.

Semin Reprod Med 2018 Nov 19;36(6):323-326. Epub 2019 Apr 19.

Walter Reed National Military Medical Center, Bethesda, Maryland.

The U.S. military mirrors the U. Read More

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http://dx.doi.org/10.1055/s-0039-1681084DOI Listing
November 2018

Reproductive Health of Women Veterans: A Systematic Review of the Literature from 2008 to 2017.

Semin Reprod Med 2018 Nov 19;36(6):315-322. Epub 2019 Apr 19.

Division of Gynecology, Department of Surgery, VA Boston Healthcare System, Boston, Massachusetts.

The literature on the reproductive health and healthcare of women Veterans has increased dramatically, though there are important gaps. This article aims to synthesize recent literature on reproductive health and healthcare of women Veterans. We updated a literature search to identify manuscripts published between 2008 and July 1, 2017. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678750
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http://dx.doi.org/10.1055/s-0039-1678750DOI Listing
November 2018
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Interaction between lifestyle behaviors and genetic polymorphism in SCAP gene on blood pressure among Chinese children.

Pediatr Res 2019 Apr 19. Epub 2019 Apr 19.

Institute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center, 100191, Beijing, China.

Backgrounds: Previous studies had revealed that sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) rs12487736 polymorphism was associated with blood pressure (BP), but whether rs12487736 could interact with lifestyle behaviors on BP is unknown.

Methods: A case-control study with 1092 Chinese children was conducted.

Results: We found an interaction between rs12487736 and high calorie foods intake (fried chips/cakes/cookies) on systolic blood pressure (SBP) (P = 0. Read More

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http://dx.doi.org/10.1038/s41390-019-0402-zDOI Listing

Conservative Management and Rehabilitation in the Older Runner With Knee Osteoarthritis: An Evidence-Based Review.

Am J Phys Med Rehabil 2019 May;98(5):416-421

From the Physical Medicine and Rehabilitation Department, MossRehab, Elkins Park, Pennsylvania (BC); and Physical Medicine, Rehabilitation and Sports Medicine Department, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico (FS, WM).

Osteoarthritis is an age-related condition that commonly affects the middle-aged and elderly population including individuals who continue to pursue an active and athletic lifestyle. Running is an easily accessible activity with many health benefits; thus, it is becoming a popular form of exercise, even in older individuals. Studies evaluating the correlation between running and osteoarthritis show conflicting results; however, most studies show an increased risk of osteoarthritis in runners with a combination of modifiable and nonmodifiable risk factors. Read More

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http://dx.doi.org/10.1097/PHM.0000000000001082DOI Listing

Co-assembled Ca Alginate-Sulfate Nanoparticles for Intracellular Plasmid DNA Delivery.

Mol Ther Nucleic Acids 2019 Mar 28;16:378-390. Epub 2019 Mar 28.

Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel; Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel; The Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. Electronic address:

Successful gene therapy requires the development of suitable carriers for the selective and efficient delivery of genes to specific target cells, with minimal toxicity. In this work, we present a non-viral vector for gene delivery composed of biocompatible materials, CaCl, plasmid DNA and the semi-synthetic anionic biopolymer alginate sulfate (AlgS), which spontaneously co-assembled to form nanoparticles (NPs). The NPs were characterized with a slightly anionic surface charge (Zeta potential [ζ] = -14 mV), an average size of 270 nm, and their suspension was stable for several days with no aggregation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S21622531193006
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http://dx.doi.org/10.1016/j.omtn.2019.03.006DOI Listing
March 2019
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Decreased cross-linking in interfacial polymerization and heteromorphic support between nanoparticles: Towards high-water and low-solute flux of hybrid forward osmosis membrane.

J Colloid Interface Sci 2019 Apr 4;548:170-183. Epub 2019 Apr 4.

State Key Laboratory of Separation Membranes and Membrane, School of Textiles, Tianjin Polytechnic University, Tianjin 300387, China.

Realizing that one main factor affecting development of forward osmosis (FO) membrane was internal concentration polarization (ICP), graphene oxide (GO) with two-dimensional structure and oxidized carbon nanotubes (OCNTs) with one-dimensional structure were linked by oxygen-containing groups to form water channels in the polyamide layer. OCNTs and GO were used for producing reactions among oxygen-containing groups of nanoparticles and polymer chains, and oxygen-containing groups were fully exposed because GO and OCNTs restrained aggregation. Decrease of cross-linking degree for interfacial polymerization layer was confirmed due to reaction from GO/OCNTs/m-phenylene diamine/1,3,5-benzenetricarbonyl trichloride. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00219797193042
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http://dx.doi.org/10.1016/j.jcis.2019.04.014DOI Listing
April 2019
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The safety and efficacy of Guluronic acid (G2013) in ankylosing spondylitis: A randomized controlled parallel clinical trial.

Pharmacol Rep 2019 Feb 10;71(3):393-398. Epub 2019 Feb 10.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: To assess the therapeutic efficacy, safety and tolerability of Guluronic acid (G2013) in patients with ankylosing spondylitis (AS) patients.

Methods: This investigation was a 12-week randomized, placebo-controlled, phase I/II clinical trial involving 75 AS patients that were randomly divided into 3 groups: 25 as placebo, 25 Guluronic acid and 25 naproxen groups. Patients who had AS with active disease at baseline according to the modified New York criteria were considered for this trial. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.002DOI Listing
February 2019

Habitual and acute exercise effects on salivary biomarkers in response to psychosocial stress.

Psychoneuroendocrinology 2019 Mar 25;106:216-225. Epub 2019 Mar 25.

Department of Sport Science, Albert-Ludwigs-University Freiburg, Schwarzwaldstraße 175, Freiburg 79117, Germany. Electronic address:

Objective: Previous research suggests beneficial effects of physical exercise on stress reactivity due to cross-stressor adaptions of physiological stress response systems. However, results remain inconclusive and it is unclear whether only regular engagement in exercise modulates these physiological adaptations or if acute bouts of exercise can elicit similar adaptations. Thus, the aim of the current study was to investigate and compare the effects of habitual and acute exercise on physiological stress responses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064530183088
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http://dx.doi.org/10.1016/j.psyneuen.2019.03.015DOI Listing
March 2019
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Synthesis, molecular properties and comparative docking and QSAR of new 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetic acid derivatives as possible anticancer agents.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 7;218:248-262. Epub 2019 Apr 7.

Chemistry Department, Faculty of Science, Al-Azhar University (Boys Branch), Nasr City, Cairo, Egypt.

Novel coumarin amino acid derivatives were synthesized. The structure of synthesized compounds has established on basis of different spectral data. The optimization geometry, frontier molecular orbitals (FMOs), thermodynamic parameters and chemical reactivity, were discussed using DFT\B3LYP by 6-311G* basis set, to identify a clear view for inter and intramolecular interaction of tested compounds. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13861425193019
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http://dx.doi.org/10.1016/j.saa.2019.02.074DOI Listing
April 2019
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Synthesis, biological activity and multiscale molecular modeling studies of bis-coumarins as selective carbonic anhydrase IX and XII inhibitors with effective cytotoxicity against hepatocellular carcinoma.

Bioorg Chem 2019 Mar 7;87:838-850. Epub 2019 Mar 7.

Sakarya University of Applied Sciences, Pamukova Vocational Highschool, Pamukova, Turkey.

A series of novel bis-coumarin derivatives containing triazole moiety as a linker between the alkyl chains was synthesized and their inhibitory activity against the human carbonic anhydrase (hCA) isoforms I, II, IX and XII were evaluated. In addition, cytotoxic effects of the synthesized compounds on renal adenocarcinoma (769P), hepatocellular carcinoma (HepG2) and breast adeno carcinoma (MDA-MB-231) cell lines were examined. While the hCA I and II isoforms were inhibited in the micromolar range, the tumor-associated isoform hCA IX and XII were inhibited in the high nanomolar range. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.03.003DOI Listing

Structural and mechanistic themes in glycoconjugate biosynthesis at membrane interfaces.

Curr Opin Struct Biol 2019 Apr 16;59:81-90. Epub 2019 Apr 16.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, United States. Electronic address:

Peripheral and integral membrane proteins feature in stepwise assembly of complex glycans and glycoconjugates. Catalysis on membrane-bound substrates features challenges with substrate solubility and active-site accessibility. However, advantages in enzyme and substrate orientation and control of lateral membrane diffusion provide order to the multistep processes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0959440X193003
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http://dx.doi.org/10.1016/j.sbi.2019.03.013DOI Listing
April 2019
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[An introduction to human factors: from aeronautic to obstetrics.]

Gynecol Obstet Fertil Senol 2019 Apr 16. Epub 2019 Apr 16.

Réseau de périnatalité MYPA (Maternité en Yvelines et Périnatalité Active), France; Service de Gynécologie-Obstétrique, Centre Hospitalier de Versailles, Le Chesnay, France.

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http://dx.doi.org/10.1016/j.gofs.2019.04.004DOI Listing

Age-dependent variations in the expression of myosin isoforms and myogenic factors during the involution of the proximal sesamoidean ligament of sheep.

Res Vet Sci 2019 Apr 11;124:270-279. Epub 2019 Apr 11.

Department of Comparative Biomedicine and Food Science, Università di Padova, Italy. Electronic address:

In ungulates the stability of the fetlock joint is dependent on several muscles, which are exposed to high stress and strain. Among those muscles, the proximal sesamoidean ligament or PSL (also known as the suspensory ligament or Ruini's elasto-tendinous organ) is organized at birth in layers of muscle fibres alternated with abundant tendinous tissue that, during the postnatal development, becomes the predominant tissue. In this study we analysed the PSL of the sheep at the age of 1, 30 and 180 days and determined the expression of several genes which either (a) are markers of muscle fibre growth and maturation, or (b) play a role as signal molecules. Read More

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http://dx.doi.org/10.1016/j.rvsc.2019.04.006DOI Listing

Aryl quinolinyl hydrazone derivatives as anti-inflammatory agents that inhibit TLR4 activation in the macrophages.

Eur J Pharm Sci 2019 Apr 16. Epub 2019 Apr 16.

Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII M, Kolkata 700054, India. Electronic address:

A series of aryl 7-chloroquinolinyl hydrazone derivatives (3a-u) have been synthesized in 55-76% yield using simple reaction condition. The synthesized compounds were evaluated for their anti-inflammatory activities based on their ability to inhibit pro-inflammatory cytokine secretion from the macrophages after stimulation with lipopolysaccharide (LPS). Three compounds appeared as promising anti-inflammatory agents. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09280987193015
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http://dx.doi.org/10.1016/j.ejps.2019.04.016DOI Listing
April 2019
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Randomized trial evaluating the role of weight loss in overweight and obese men with early stage prostate Cancer on active surveillance: Rationale and design of the Prostate Cancer Active Lifestyle Study (PALS).

Contemp Clin Trials 2019 Apr 16. Epub 2019 Apr 16.

Fred Hutchinson Cancer Research Center, United States; Veterans Affairs Puget Sound Health Care System, United States; University of Washington, United States.

Active surveillance (AS) is increasingly used to monitor patients with low-risk prostate cancer; however, approximately 50% of AS patients experience disease reclassification requiring definitive treatment and little is known about patient characteristics that modify the risk of reclassification. Obesity may be one of the major contributing factors. The Prostate Cancer Active Lifestyle Study (PALS) is a clinical trial evaluating the impact of weight loss among overweight/obese (Body Mass Index (BMI) ≥ 25 kg/m) men with clinically localized prostate cancer on AS. Read More

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http://dx.doi.org/10.1016/j.cct.2019.04.004DOI Listing

Blood-to-brain communication in the hypothalamus for energy intake regulation.

Neurochem Int 2019 Apr 16. Epub 2019 Apr 16.

Department of Anatomy & Neuroscience, Faculty of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara ,634-8521, Japan.

The arcuate nucleus (Arc) integrates circulating hormonal and metabolic signals to control energy expenditure and intake. One of the most important routes that enables the Arc to sense circulating molecules is through the median eminence (ME), which lacks a typical blood-brain barrier. However, the mechanism by which circulating molecules reach the Arc neurons remains unclear. Read More

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http://dx.doi.org/10.1016/j.neuint.2019.04.007DOI Listing

Nuclear receptors, cholesterol homeostasis and the immune system.

J Steroid Biochem Mol Biol 2019 Apr 16. Epub 2019 Apr 16.

Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, IL, United States; Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, IL, United States; Cancer Center at Illinois, University of Illinois at Urbana Champaign, Urbana, IL, United States; University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL, United States; Carl R. Woese Institute for Genomic Biology, Anticancer Discovery from Pets to People Theme, University of Illinois at Urbana Champaign, Urbana, IL, United States. Electronic address:

Cholesterol is essential for maintaining membrane fluidity in eukaryotes. Additionally, the synthetic cascade of cholesterol results in precursor molecules important for cellular function such as lipid raft formation and protein prenylation. As such, cholesterol homeostasis is tightly regulated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09600760193005
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http://dx.doi.org/10.1016/j.jsbmb.2019.04.013DOI Listing
April 2019
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Two-component cross-linkable gels for fabrication of solid oral dosage forms.

J Control Release 2019 Apr 16. Epub 2019 Apr 16.

Faculty of Biotechnology and Food Engineering, Technion - Israel Institute of Technology, Haifa 3200003, Israel; Russell Berrie Nanotechnology Institute, Technion - Israel Institute of Technology, Haifa 3200003, Israel.

Current three-dimensional (3D) printing techniques involve the solidification of the injected materials by means of UV irradiation, evaporation of organic solvents, or harsh heating and cooling processes. These methods limit the printing of many sensitive bio-active molecules such as proteins. We describe a novel 3D printing technique based on two complementary liquid copolymers, PEG-PCL-SC and PEG-PCL-NH, that are injected in a coordinated fashion and react with each other to form a pre-designed 3D pill. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01683659193022
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http://dx.doi.org/10.1016/j.jconrel.2019.04.021DOI Listing
April 2019
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Binding characterization of aptamer-drug layered microformulations and in vitro release assessment.

J Pharm Sci 2019 Apr 16. Epub 2019 Apr 16.

Department of Chemical Engineering, Curtin University, Sarawak 98009, Malaysia.

Efficient delivery of adequate active ingredients to targeted malignant cells is critical, attributing to recurrent biophysical and biochemical challenges associated with conventional pharmaceutical delivery systems. These challenges include drug leakage, low targeting capability, high systemic cytotoxicity, and poor pharmacokinetics and pharmacodynamics. Targeted delivery system is a promising development to deliver sufficient amounts of drug molecules to target cells in a controlled release pattern mode. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.03.037DOI Listing

Ginsenoside Rg1 attenuates hepatic insulin resistance induced by high-fat and high-sugar by inhibiting inflammation.

Eur J Pharmacol 2019 Apr 16. Epub 2019 Apr 16.

Department of Biochemistry and Molecular Biology, School of Basic Medicine, Kunming Medical University, Kunming, Yunnan, 650500, PR China; Yunnan Province Key Laboratory for Nutrition and Food Safety in Universities, PR China. Electronic address:

Ginsenoside Rg1 is the active ingredient of Chinese herbal medicine ginseng and sanqi, which has remarkable effects on anti-inflammation and anti-diabetes. In this study, we explored the molecular mechanism of ginsenoside Rg1 against diabetes in rat subjected to insulin resistance induced by high-fat and high-sugar (HFHS). Biochemical analysis revealed that ginsenoside Rg1 significantly decreased the serum levels of alanine transaminase, aspartate transaminase, alkaline phosphatase, total cholesterol, triglyceride, low-density lipoprotein and increased the serum levels of high-density lipoprotein, which indicated ginsenoside Rg1 improved the extent of hepatic steatosis. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.04.027DOI Listing

Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection.

J Mol Biol 2019 Apr 16. Epub 2019 Apr 16.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, United States of America; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, United States of America; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, United States of America. Electronic address:

Urinary tract infections (UTIs) are the most commonly reported infections in adult women and have high rates of recurrence, especially in postmenopausal women. Recurrent UTI (RUTI) greatly reduces quality of life, places a significant burden on the healthcare system, and contributes to antimicrobial resistance. Because treatment of RUTI by long-term antibiotic therapy is often ineffective or poorly tolerated in elderly women, new therapies must be developed. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.04.008DOI Listing

Crystal structure of Plasmodium falciparum adenosine deaminase reveals a novel binding pocket for inosine.

Arch Biochem Biophys 2019 Apr 16. Epub 2019 Apr 16.

National Center for Genetic Engineering and Biotechnology, 113 Thailand Science Park, Phahonyothin Road, Klong 1, Klong Luang, Pathumthani, 12120, Thailand. Electronic address:

Plasmodium falciparum (Pf), a malarial pathogen, can only synthesize purine nucleotides employing a salvage pathway because it lacks de novo biosynthesis. Adenosine deaminase (ADA), one of the three purine salvage enzymes, catalyzes the irreversible hydrolytic deamination of adenosine to inosine, which is further converted to GMP and AMP for DNA/RNA production. In addition to adenosine conversion, Plasmodium ADA also catalyzes the conversion of 5'-methylthioadenosine, derived from polyamine biosynthesis, into 5'-methylthioinosine whereas the human enzyme is not capable of this function. Read More

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http://dx.doi.org/10.1016/j.abb.2019.04.002DOI Listing

Core catalysis of the reductive glycine pathway demonstrated in yeast.

ACS Synth Biol 2019 Apr 19. Epub 2019 Apr 19.

One-carbon (C1) compounds are attractive microbial feedstocks as they can be efficiently produced from widely available resources. Formate, in particular, represents a promising growth substrate, as it can be generated from electrochemical reduction of CO2 and fed to microorganisms in a soluble form. We previously identified the synthetic reductive glycine pathway as the most efficient route for aerobic growth on formate. Read More

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http://pubs.acs.org/doi/10.1021/acssynbio.8b00464
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http://dx.doi.org/10.1021/acssynbio.8b00464DOI Listing
April 2019
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Isolation of ceramides from Tagetes patula L. yellow flowers and nematicidal activity of the fractions and pure compounds against cyst nematode, Heterodera zeae.

Chem Biodivers 2019 Apr 19. Epub 2019 Apr 19.

University of Karachi International Center for Chemical and Biological Sciences, International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry,, International Centre for Chemical and, Biological Sciences (ICCBS),, University of Karachi, Karachi -75270, 75270, Karachi, PAKISTAN.

Investigation of yellow flower extract of Tagetes patula L. led to the identification of an aggregate of five phytoceramides. Among them, (2S, 3S, 4R, 8E)-2-[(R)-2'-hydroxyeicosanoylamino]-8-en-1, 3, 4-eicosenetriol; (2S, 3S, 4R, 8E)-2-[(R)-2'-hydroxyheneicosanoylamino]-8-en-1, 3, 4-eicosenetriol; (2S, 3S, 4R, 8E)-2-[(R)-2'-hydroxydocosanoyl- amino]-8-en-1, 3, 4-eicosenetriol and (2S, 3S, 4R, 8E)-2-[(R)-2'-hydroxytricosanoylamino]-8-en-1, 3, 4-eicosenetriol were identified as new compounds and termed as tagetceramides, whereas (2S, 3S, 4R, 8E)-2-[(R)-2'-hydroxytetracosanoylamino]-8-en-1,3,4-eicosenetriol was a known ceramide. Read More

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http://dx.doi.org/10.1002/cbdv.201900092DOI Listing

Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria.

PLoS Pathog 2019 Apr 19;15(4):e1007723. Epub 2019 Apr 19.

Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, United States of America.

Staphylococcus aureus and other bacterial pathogens affix wall teichoic acids (WTAs) to their surface. These highly abundant anionic glycopolymers have critical functions in bacterial physiology and their susceptibility to β-lactam antibiotics. The membrane-associated TagA glycosyltransferase (GT) catalyzes the first-committed step in WTA biosynthesis and is a founding member of the WecB/TagA/CpsF GT family, more than 6,000 enzymes that synthesize a range of extracellular polysaccharides through a poorly understood mechanism. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007723DOI Listing

Sero-prevalence of Hepatitis B and C viral co-infections among HIV-1 infected ART-naïve individuals in Kumasi, Ghana.

PLoS One 2019 19;14(4):e0215377. Epub 2019 Apr 19.

Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Background: The study assessed the hepatitis B virus (HBV) and hepatitis C virus (HCV) co-infection paradigm among the human immunodeficiency virus (HIV) infected patients attending a tertiary hospital in Ghana. Also, the immunological and virological characterisation of these viruses, prior to antiretroviral therapy (ART) initiation was investigated.

Method: A total of 400 HIV infected (HIV type-1) treatment naïve subjects ≥18 years were enrolled and tested for HBsAg and anti-HCV. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215377PLOS

A fast two-stage active contour model for intensity inhomogeneous image segmentation.

PLoS One 2019 19;14(4):e0214851. Epub 2019 Apr 19.

Department of Applied Mathematics, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, PR China.

This paper presents a fast two-stage image segmentation method for intensity inhomogeneous image using an energy function based on a local region-based active contour model with exponential family. In the first stage, we preliminary segment the down-sampled images by the local correntropy-based K-means clustering model with exponential family, which can fast obtain a coarse result with low computational complexity. Subsequently, by taking the up-sampled contour of the first stage as initialization, we precisely segment the original images by the improved local correntropy-based K-means clustering model with exponential family in the second stage. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214851PLOS
April 2019
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Assessing the Bioavailability of Zinc and Indole Compounds from Mycelial Cultures of the Bay Mushroom Imleria badia (Agaricomycetes) Using In Vitro Models.

Int J Med Mushrooms 2019 ;21(4):343-352

Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland.

Zinc and indole compounds demonstrate anti-inflammatory, antidepressant, and antioxidant activity. Edible mushrooms are good sources of these substances. Therefore, in this study, we aimed to study the accumulation, release, and absorption of zinc and indole compounds from mycelial cultures of Imleria badia species using in vitro models. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019030328DOI Listing
January 2019

Gene Delivery Using Lipoplexes and Polyplexes: Principles, Limitations and Solutions.

Crit Rev Eukaryot Gene Expr 2019 ;29(1):29-36

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Gene therapy has attracted considerable attention for the treatment of genetic and acquired diseases. Successful gene therapy occurs when the therapeutic genes penetrate targeted cells and become available to the intracellular active site. Currently, a promising approach in gene delivery is the use of nonviral gene delivery vectors that lack immunogenicity but have low toxicity and potential tissue specificity. Read More

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http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2018025132DOI Listing
January 2019

Simulating Time-Dependent Patterns of Nonadherence by Patients With Breast Cancer to Adjuvant Oral Endocrine Therapy.

JCO Clin Cancer Inform 2019 Apr(3):1-9

1 University of Texas MD Anderson Cancer Center, Houston, TX.

Purpose: Nearly 40% of patients with breast cancer discontinue their adjuvant oral endocrine treatment (ET). We measured discontinuation rates of ET at a comprehensive cancer center. We then used an iterative approach to model patterns of determinants associated with discontinuation of ET. Read More

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https://ascopubs.org/doi/10.1200/CCI.18.00091
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http://dx.doi.org/10.1200/CCI.18.00091DOI Listing
April 2019
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Cascading Interfaces Enable N-Si Photoanode for Efficient and Stable Solar Water Oxidation.

J Phys Chem Lett 2019 Apr 19. Epub 2019 Apr 19.

The interfaces with multi-functions for the promoted solid/solid interfacial charge transfer dynamics and the accelerated solid/electrolyte interfacial water redox reaction kinetics are determinative to the photoelectrodes achieving high performances for photoelectrochemical (PEC) water splitting. In this work, the well-designed cascading interfaces are introduced in the n-Si photoanode, which is effectively protected by an atomic layer deposited CoOx thin layer for stabilizing the n-Si photoanode and then coated with an earth-abundant NiCuOx layer for catalyzing water oxidation reaction. Furthermore, the formed n-Si/CoOx/NiCuOx triple-junction could generate a large band bending to provide a considerable photovoltage for promoting the photoinduced charge transfer and separation processes at the n-Si/CoOx/NiCuOx cascading interfaces. Read More

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http://pubs.acs.org/doi/10.1021/acs.jpclett.9b00746
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http://dx.doi.org/10.1021/acs.jpclett.9b00746DOI Listing
April 2019
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Self-Assembled Oxaliplatin(IV) Prodrug-Porphyrin Conjugate for Combinational Photodynamic and Chemotherapy.

ACS Appl Mater Interfaces 2019 Apr 19. Epub 2019 Apr 19.

Nanomedicine has emerged as a promising strategy for effective cancer treatment. A useful approach is to develop carrier-free nanodrugs via facile supramolecular self-assembly process. To achieve high therapeutic effect, integrating photodynamic therapy with chemotherapy has been sought after. Read More

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http://dx.doi.org/10.1021/acsami.9b04557DOI Listing

Small Molecule Potentiation of Gram-positive Selective Antibiotics Against Acinetobacter baumannii.

ACS Infect Dis 2019 Apr 19. Epub 2019 Apr 19.

In 2016, the World Health Organization deemed antibiotic resistance one of the biggest threats to global health, food security, and development. The need for new methods to combat infections caused by antibiotic resistant pathogens will require a variety of approaches to identifying effective new therapeutic strategies. One approach is the identification of small molecule adjuvants that potentiate the activity of antibiotics of demonstrated utility, whose efficacy is abated by resistance, both acquired and intrinsic. Read More

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http://pubs.acs.org/doi/10.1021/acsinfecdis.9b00067
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http://dx.doi.org/10.1021/acsinfecdis.9b00067DOI Listing
April 2019
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Tao negatively regulates BMP signaling during neuromuscular junction development in Drosophila.

Dev Neurobiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Biology, John Carroll University, University Heights, OH, 44118, USA.

The coordinated growth and development of synapses is critical for all aspects of neural circuit function and mutations that disrupt these processes can result in various neurological defects. Several anterograde and retrograde signaling pathways, including the canonical Bone Morphogenic Protein (BMP) pathway, regulate synaptic development in vertebrates and invertebrates. At the Drosophila larval neuromuscular junction (NMJ), the retrograde BMP pathway is part of the machinery that controls NMJ expansion concurrent with larval growth. Read More

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http://dx.doi.org/10.1002/dneu.22681DOI Listing

Making it stick: A CURE designed to introduce students to the scientific process and the host response to foreign materials.

Biochem Mol Biol Educ 2019 Apr 19. Epub 2019 Apr 19.

Department of Biology, Penn State University, Lehigh Valley, Center Valley, Pennsylvania 18034.

Often overlooked in many molecular cell biology laboratory and cell culture courses, suspension cells represent an important aspect of molecular cell biology and cell culture. Most primary cell cultures and cell lines are adherent cells which grow in monolayers on surfaces. However, other cells such as hematopoietic cells, certain tumor cells, and cells of the immune system are suspension cells which are anchorage-independent which grow and divide in solution. Read More

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http://dx.doi.org/10.1002/bmb.21248DOI Listing

Further modifications of 1H-pyrrolo[2,3-b]pyridine derivatives as inhibitors of human neutrophil elastase.

Drug Dev Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Microbiology and Immunology, Montana State University, Bozeman, Montana.

Human neutrophil elastase (HNE) is a potent protease that plays an important physiological role in many processes and is considered to be a multifunctional enzyme. HNE is also involved in a variety of pathologies affecting the respiratory system. Thus, compounds able to inhibit HNE proteolytic activity could represent effective therapeutics. Read More

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http://dx.doi.org/10.1002/ddr.21539DOI Listing

Pomolic acid exhibits anticancer potential against a docetaxel‑resistant PC3 prostate cell line.

Oncol Rep 2019 Apr 19. Epub 2019 Apr 19.

Laboratory of Immunopathology, Institute of Biophysics Carlos Chagas Filho (IBCCF), Federal University of Rio de Janeiro, 21949‑900 Rio de Janeiro, RJ, Brazil.

Prostate cancer (PC) is one of the leading causes of cancer‑related death in the male population worldwide. Mortality of PC is dependent on tumor recurrence and its progression to metastatic disease. We examined the effects of pentacyclic triterpene pomolic acid (PA) on docetaxel‑resistant PC3 cells. Read More

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http://dx.doi.org/10.3892/or.2019.7132DOI Listing

Resveratrol analogues surprisingly effective against triple‑negative breast cancer, independent of ERα.

Oncol Rep 2019 Apr 16. Epub 2019 Apr 16.

Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA.

Resveratrol, a plant‑derived stilbene compound, has exhibited anticancerous properties, including breast cancer. Stilbenes have a molecular structure highly similar to estrogen and have the ability to bind estrogen receptors and regulate activity. Numerous studies have demonstrated the effectiveness of resveratrol in estrogen receptor‑positive (ER‑positive) subtypes of breast cancer, yet the effects in ER‑negative subtypes, including triple‑negative breast cancer (TNBC), have been limited. Read More

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http://www.spandidos-publications.com/10.3892/or.2019.7122
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http://dx.doi.org/10.3892/or.2019.7122DOI Listing
April 2019
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Differential expression of tescalcin by modification of promoter methylation controls cell survival in gastric cancer cells.

Oncol Rep 2019 Apr 4. Epub 2019 Apr 4.

Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34824, Republic of Korea.

The EF‑hand calcium binding protein tescalcin (TESC) is highly expressed in various human and mouse cancer tissues and is therefore considered a potential oncogene. However, the underlying mechanism that governs TESC expression remains unclear. Emerging evidence suggests that TESC expression is under epigenetic regulation. Read More

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http://dx.doi.org/10.3892/or.2019.7099DOI Listing

A Scoping Review of Nonpharmacological Interventions to Reduce Disability in Older Adults.

Gerontologist 2019 Apr 19. Epub 2019 Apr 19.

Department of Occupational Therapy, School of Health and Rehabilitation Science, Pennsylvania.

Background And Objectives: Minimizing disability is critical to reduce the costly health care associated with disability and maintain quality of life into old age. We examined the effect sizes of nonpharmacological intervention studies in reducing disability and explored the active ingredients of interventions.

Research Design And Methods: A scoping review was conducted via PubMed, PsycINFO, and CINAHL databases. Read More

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http://dx.doi.org/10.1093/geront/gnz026DOI Listing

Most clinical anti-EGFR antibodies do not neutralize both wtEGFR and EGFRvIII activation in glioma.

Neuro Oncol 2019 Apr 19. Epub 2019 Apr 19.

Brain Cancer Discovery Collaborative, Australia.

Background: Although the epidermal growth factor receptor (EGFR) and its truncated, autoactive mutant EGFRvIII are bona fide drivers of tumorigenesis in some gliomas, therapeutic antibodies developed to neutralize this axis have not improved patient survival in a limited number of trials. Previous studies using cells transduced to exogenously express EGFRvIII may have compromised mechanistic studies of anti-EGFR therapeutics. Therefore, we re-assessed the activity of clinical EGFR antibodies in patient-derived gliomaspheres that endogenously express EGFRvIII. Read More

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http://dx.doi.org/10.1093/neuonc/noz073DOI Listing

Predicting Outcomes from Engagement With Specific Components of an Internet-Based Physical Activity Intervention With Financial Incentives: Process Analysis of a Cluster Randomized Controlled Trial.

J Med Internet Res 2019 Apr 19;21(4):e11394. Epub 2019 Apr 19.

Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.

Background: Investigating participant engagement and nonusage attrition can help identify the likely active ingredients of electronic health interventions. Research on engagement can identify which intervention components predict health outcomes. Research on nonusage attrition is important to make recommendations for retaining participants in future studies. Read More

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http://dx.doi.org/10.2196/11394DOI Listing

{Zn} Cluster Based Metal-Organic Framework with Enhanced Room-Temperature Phosphorescence and Optoelectronic Performances.

Inorg Chem 2019 Apr 19. Epub 2019 Apr 19.

College of Chemistry and Chemical Engineering, Henan Province Function-oriented Porous Materials Key Laboratory , Luoyang Normal University , Luoyang 471934 , PR China.

Molecule-based solid-state materials with long lifetimes could enable longer migration distances for excitons, which are beneficial for vast applications in optoelectronic field. Herein, we report a hexanuclear zinc cluster based MOF exhibits highly enhanced phosphorescence about 2 orders of magnitude in comparison with the pristine phosphor ligand. The combination of both experimental and computational results suggest that the {Zn} cluster is very important for adjusting molecular conformations, packing arrangement, and photophysical properties of the organic phosphor ligands within the MOF matrix. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00450DOI Listing

Boronic Derivatization of Monoacylglycerol and Monitoring in Biofluids.

Anal Chem 2019 Apr 19. Epub 2019 Apr 19.

Monoacylglycerols (MAGs) are active mediators involved in multiple biological processes closely related to the pathological de-velopment of diabetes, obesity and cancers. Sensitive and unambiguous detection of MAG is thus essential; however, previous methods are both indirect and labor-intensive. Herein, we developed a straightforward approach by derivatization of MAGs with 3-nitrophenylboronic acid (3-NPB) for sensitive and selective analysis in cell lysates, tissues and serums by mass spectrometry (MS). Read More

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http://pubs.acs.org/doi/10.1021/acs.analchem.9b00805
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http://dx.doi.org/10.1021/acs.analchem.9b00805DOI Listing
April 2019
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Molecular imaging of neuroinflammation in patients after mild traumatic brain injury: a longitudinal I-CLINDE SPECT study.

Eur J Neurol 2019 Apr 19. Epub 2019 Apr 19.

Neurobiology Research Unit, Rigshospitalet, Copenhagen, Denmark.

Background: Neuroinflammation has been proposed as part of the pathogenesis of post-concussion symptoms (PCS), but the inflammatory response of the human brain to mild traumatic brain injury (mTBI) remains unknown. We hypothesized that a neuroinflammatory response is present in mild traumatic brain injury (mTBI) at 1-2 weeks post-injury and persists in patients with PCS.

Methods: We scanned 14 mTBI patients without signs of structural damage 1-2 weeks and 3-4 months post-injury and 22 healthy controls once using the SPECT tracer I-CLINDE, which visualizes TSPO, a protein upregulated in active immune cells. Read More

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http://dx.doi.org/10.1111/ene.13971DOI Listing

Differential Regulation of Gonadotropins in Response to Continuous Infusion of Native Gonadotropin-Releasing Hormone in the Winter Anovulatory Mare and Effects of Treatment With Estradiol-17β.

J Equine Vet Sci 2019 Apr 6;75:93-103. Epub 2019 Feb 6.

Animal Reproduction Laboratory, Texas A&M AgriLife Research, Beeville, TX; Department of Animal Science, Texas A&M University, College Station, TX. Electronic address:

We tested the hypotheses that in winter anovulatory mares (1) both chronic daily injections of estradiol-17β (E2) and subcutaneous E2 implants could enhance pituitary secretion of gonadotropins in response to continuous subcutaneous infusion of native gonadotropin-releasing hormone (GnRH); and (2) the secretory pattern of follicle-stimulating hormone (FSH) in response to continuous subcutaneous infusion of native GnRH is similar to that of luteinizing hormone (LH) but differs between mares that develop or fail to develop an estrogen-active, preovulatory follicle. In Experiment 1, 20 winter anovulatory mares (n = 5 per group) in early February received twice-daily injections of corn oil (control) or 5 mg of E2 with or without continuous subcutaneous treatment with native GnRH (100 μg/hr) or received GnRH only for up to 14 days. In Experiment 2, 24 winter anovulatory mares (n = 6 per group) were treated with a full-length (high dose) or quarter-length (low dose) E2 implant (Compudose) in combination with continuous GnRH infusion (100 μg/hr) for up to 28 days or served as sham controls. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07370806183072
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http://dx.doi.org/10.1016/j.jevs.2019.01.013DOI Listing
April 2019
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