Support Care Cancer 2016 Oct 10;24(10):4241-8. Epub 2016 May 10.

Department of Dermatology, Medical Faculty, University of Düsseldorf, Moorenstrasse 5, D-40225, Duesseldorf, Germany.

Background: The mechanisms of skin aging have not been completely elucidated. Anecdotal data suggests that EGFR inhibition accelerates aging-like skin changes.

Objective: The objective of the study was to evaluate the clinical characteristics and investigate the cellular and molecular mechanisms underlying skin changes associated with the use of EFGRIs. Read More

Conn Med 2016 Jan;80(1):15-7

A variety of medical conditions and medications can lead to cutaneous dyschromia. We report a case of minocycline dyschromia that had been mistakenly attributed to chronic actinic purpura. Read More

J Dermatol 2015 Oct 15;42(10):967-74. Epub 2015 Jun 15.

Department of Dermatology and Wound Healing, School of Medicine, Cardiff University, Cardiff, UK.

Human T-lymphotropic virus type 1 (HTLV-1) induces adult T-cell leukemia/lymphoma (ATLL), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and carrier. ATLL is a mature CD4+ CD25+ CCR4+ T-cell neoplasm, and approximately half of patients have direct skin involvement manifesting patch, plaque, tumor, multiple papules, erythroderma and purpura. However, there exist secondary eruptions without tumor cell infiltration in patients with ATLL or HAM/TSP and carriers of HTLV-1. Read More

Dermatol Online J 2014 Jan 15;20(1):21246. Epub 2014 Jan 15.

University of California, Davis.

Chemotherapy-induced inflammation of actinic keratosis can present in patients with subclinical actinic keratoses that become erythematous and pruritic within weeks of initiating systemic chemotherapy. The reaction is limited to sun-exposed areas and, classically, histologic findings of parakeratosis and epidermal necrosis with keratinocyte nuclear pleomorphism are present. Exuberant reactions with extensive epidermal necrosis may lead to subepidermal vesiculation. Read More

Ned Tijdschr Geneeskd 2013 ;156(0):A3305

Waterland Ziekenhuis, afd. Dermatologie, Purmerend.

A 56-year-old woman presented with red-purple blotches on both forearms which had suddenly appeared without any pain, pruritus or trauma. Laboratory investigation showed no abnormalities. Histopathology revealed non-inflammatory actinic purpura. Read More

Indian J Dermatol 2012 Nov;57(6):424-7

Department of Pathology, St. John's Medical College, Bangalore, India.

Unlabelled: Patch-stage/early mycosis fungoides (MF) is difficult to differentiate from benign dermatoses, despite several robust histologic criteria. Most studies include advanced lesions and data about early disease is limited.

Objectives: (1) To compare the CD4:CD8 ratio in patch-stage MF versus inflammatory mimics. Read More

J Cosmet Laser Ther 2011 Jun;13(3):113-9

Background: Premalignancies resulting from photodamage, such as actinic keratosis and carcinoma in situ, can be treated with various modalities. Most of these treatments may reverse or treat these conditions although they often involve considerable skin irritation over a long period of time, are very uncomfortable for the patients or they need many office visits and sometimes are very expensive, such as photodynamic therapy (PDT).

Objective: To study the effectiveness of a mixed session of Q-switched KTP 532 nm and Nd:YAG 1064 nm laser treatment on precancerous lesions resulting from solar damage. Read More

Acta Dermatovenerol Croat 2010 ;18(3):176-80

University Hospital Center Zagreb , Department of Dermatology and Venereology, School of Medicine, University of Zagreb, Šalata 4, Zagreb, Croatia.

Skin aging includes intrinsic aging, a universal and inevitable process attributable to the passage of the time alone; and photoaging, changes attributable to chronic sun exposure, which are neither universal nor inevitable. The major clinical features of aging skin include xerosis, laxity, wrinkles, slackness, and the occurrence of benign neoplasms such as seborrheic keratoses and cherry angiomas. Photoaging is characterized by dryness (roughness), actinic keratoses, irregular pigmentation (freckling, lentigines, guttate hypomelanosis, persistent hyperpigmentation), wrinkling, stellate pseudoscars, elastosis (fine nodularity and/or coarseness), inelasticity, telangiectasia, venous lakes, purpura (easy bruising), comedones (maladie de Favre et Racouchot) and sebaceous hyperplasia. Read More

J Dermatol 2007 Jan;34(1):65-7

Department of Dermatology, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Korea.

Bowen's disease (BD) is a squamous cell carcinoma in situ characterized by a well-demarcated scaly erythematous thin plaque with an irregular outline. Clinically, BD is frequently misdiagnosed as superficial basal cell carcinoma, patches of dermatitis, psoriasis, lichen planus, actinic keratosis, benign lichenoid keratosis, irritated seborrheic keratosis, viral warts, amelanotic melanoma or melanoma. However, angiosarcoma has not usually been mentioned in the differential diagnosis of BD before. Read More

J Drugs Dermatol 2004 Sep-Oct;3(5):548-51

Yale University School of Medicine, Department of Dermatology, New Haven, CT, USA.

Actinic cheilitis (AC) is a common precancerous condition for which a safe, effective, rapid, and cosmetically favorable treatment is needed. The objective of this study was to assess the safety and efficacy of the long-pulsed pulsed dye laser (LP PDL) (595 nm) with photodynamic therapy (PDT) for the treatment of AC. This study was designed to be a prospective, proof-of concept pilot study to assess safety and efficacy of LP PDL in conjunction with topical 20% 5-aminolevulinic acid solution PDT for the treatment of AC. Read More

Arch Dermatol 2003 Oct;139(10):1313-20

Laser & Skin Surgery Center of New York, New York 10016, USA.

Objective: To assess the safety and efficacy of the long-pulsed pulsed dye laser (LP PDL) (595 nm) with photodynamic therapy (PDT) for treatment of actinic keratoses (AKs).

Design: Prospective, controlled study with 10-day and 2-, 4-,6-, and 8-month follow-ups.

Setting: Clinical research center. Read More

Dermatol Surg 2002 Dec;28(12):1103-6

Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, Florida, USA.

Background: Actinic purpura (AP) is an important medical issue and quality of life issue in the elderly. Current treatment of AP is limited to prevention of cutaneous aging.

Objective: To assess the utility of tissue engineered skin (Apligraf, Organogenesis, Canton, MA) as a tissue modulator in diseased skin and as treatment for AP. Read More

Ann Dermatol Venereol 2002 Oct;129(10 Pt 1):1134-8

Service de Dermatologie, CHU Saint-Jacques, Besançon.

Introduction: Organ transplanted patients exhibit cutaneous lesions caused by immunosuppressive treatment and/or immunosuppression itself. Several selected studies concerning kidney transplants have been reported, but few concerning liver transplants. We report a retrospective study of skin diseases after liver transplantation. Read More

Dermatol Clin 2000 Jan;18(1):99-112

Center for Dermatologic Surgery, Cooper Health System, Marlton, New Jersey, USA.

It is easy to become too busy treating the sequelae of photoaging, actinic keratoses, and skin cancers to discuss prevention adequately with patients. With children, sun-protective measures and sunscreen information should be the main therapeutic intervention. In any young adult with an actinic keratosis or skin cancer, topical and resurfacing treatments should be considered. Read More

Int J Dermatol 1995 Aug;34(8):546-50

Department of Dermatology, University of Granada Hospital, Spain.

Background: Although hemodialysis has been associated with lesions of cutaneous aging, no controlled studies have been done in patients with chronic renal failure under periodic hemodialysis. Our purpose was to determine the prevalence of several clinical parameters of cutaneous aging and their relationship with hemodialysis.

Methods: One hundred fourteen patients on chronic hemodialysis were investigated for the presence of several cutaneous aging markers in a cross-sectional study, using multivariate analysis to minimize the confounding effect of age. Read More

Arch Dermatol 1995 Apr;131(4):493-5

Br J Dermatol 1992 Sep;127 Suppl 41:37-42

Department of Dermatology, University of Michigan Medical Center, Ann Arbor 48109-0314.

The distinction between intrinsic and extrinsic ageing can be made on both histological and clinical grounds. Clinical criteria associated with the diagnosis of extrinsic ageing are coarse wrinkles, actinic lentigines, elastotic conditions, purpura, telangiectasia and cutaneous neoplasms. These parameters are always superimposed on changes associated with intrinsic ageing: namely, fine wrinkles and benign growths. Read More

Z Gerontol 1988 Sep-Oct;21(5):264-6

Ludwig-Boltzmann-Institut für dermatovenerologische Serodiagnostik, Wien, Osterreich.

Skin changes in advanced age consist mainly of an atrophy of the epidermis and of the appendices as well as of degeneration within the corium which cause asteatosis, purpura, de and hyperpigmentation and elastosis. The regulation of the body-temperature is altered. The influence of light leads up to actinic keratoses and to skin cancer. Read More

J Am Acad Dermatol 1986 Oct;15(4 Pt 1):650-6

Actinic damage of dermal tissues produces several distinct clinical patterns. Three patients are described as having discrete, soft, cordlike bands on the forearms that extend from dorsal areas of actinic damage and senile purpura to greatest prominence in flexural regions with less solar damage. Histochemical analyses and light and electron microscopy studies of the plaques showed changes consistent with solar elastosis. Read More

Lyon Med 1951 Jun;184(22):376-7