177 results match your criteria Actinic Prurigo


CARMIL2-related immunodeficiency manifesting with photosensitivity.

Pediatr Dermatol 2020 Apr 27. Epub 2020 Apr 27.

Departments of Dermatology and Pediatrics, Columbia University Irving Medical Center, New York, New York.

We report a case of a newly recognized primary immunodeficiency due to biallelic mutations in CARMIL2 manifesting as an actinic prurigo-like photodermatitis, allergic diathesis and recurrent infections in a child. We present this case to highlight a rare phenotype seen in this T-cell immunodeficiency and provide an overview of other dermatologic manifestations among published reports of this condition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pde.14173DOI Listing

Thalidomide: An option for the pediatric patient with actinic prurigo.

Pediatr Dermatol 2020 Mar 25;37(2):362-365. Epub 2019 Dec 25.

Dermatology Department, Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.

Actinic prurigo (AP) is an immune-mediated photodermatosis that usually starts in childhood and is predominant among American indigenous and mestizo communities. In adults with AP, thalidomide is the treatment of choice; however, there is little information on its use in pediatric patients. We report the case of a 10-year-old girl with AP treated successfully with thalidomide. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pde.14086DOI Listing

Phototherapy in the Evaluation and Management of Photodermatoses.

Dermatol Clin 2020 Jan 18;38(1):71-77. Epub 2019 Oct 18.

Department of Dermatology, Henry Ford Health System, 3031 West Grand Boulevard, Suite 800, Detroit, MI 48202, USA. Electronic address:

Ultraviolet light (UV) and visible light are important components in the diagnosis of photodermatoses, and UV has the unique ability to also be used to manage photodermatoses. Phototesting, provocative light testing, and photopatch testing can provide important information in diagnosing patients with photodermatoses; phototesting can be used to determine the starting dose for phototherapy in these patients. Once photosensitivity is established, narrowband UVB and UVA1 therapy have helped to improve the quality of life of photosensitive patients, such as those with polymorphous light eruption, chronic actinic dermatitis, and solar urticaria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.det.2019.08.007DOI Listing
January 2020

Epidermal Langerhans cells resistance to solar-simulated radiation in actinic prurigo patients with low minimal erythema dose.

Photodermatol Photoimmunol Photomed 2020 Mar 22;36(2):105-110. Epub 2019 Oct 22.

Pathology Department, Hospital Universitario de la Fundacion Santafe de Bogotá, Bogotá, Colombia.

Background: Actinic prurigo is a chronic photodermatosis of unclear pathogenesis. Epidermal Langerhans cell resistance to migration after ultraviolet radiation exposure has been proposed as a possible mechanism, as occurs in polymorphic light eruption patients. The purpose of this study was to evaluate the effect of solar-simulated radiation (SSR) on epidermal Langerhans cells in the uninvolved skin of actinic prurigo patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/phpp.12514DOI Listing
March 2020
2 Reads

Actinic prurigo: a condition that affects the Latin American population.

Int J Dermatol 2019 Nov 27;58(11):e220-e221. Epub 2019 Jul 27.

Department of Dermatology, General Hospital "Dr. Manuel Gea González, Mexico City, Mexico.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijd.14600DOI Listing
November 2019
2 Reads

Serum cytokine profiling in patients with actinic prurigo.

Eur J Dermatol 2018 Dec;28(6):850-851

Department of Dermatology, General Hospital "Dr. Manuel Gea González", Mexico City, Mexico.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/ejd.2018.3435DOI Listing
December 2018
42 Reads

Papular Eruption on Sun-Exposed Skin.

Actas Dermosifiliogr 2019 May 25;110(4):309-310. Epub 2018 Oct 25.

Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, España.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ad.2017.11.024DOI Listing
May 2019
1 Read

Photocontact Dermatitis and Its Clinical Mimics: an Overview for the Allergist.

Clin Rev Allergy Immunol 2019 Feb;56(1):32-40

Department of Dermatology, The University of Texas Southwestern, 5323 Harry Hines Blvd, Dallas, TX, 75390-9069, USA.

Photo-contact dermatitis (PCD) describes the adverse cutaneous reaction that occurs in some patients as a result of simultaneous exposure to a contactant and to light. PCD can be subdivided into photo-allergic and photo-irritant dermatitis depending on whether the contactant respectively invokes an allergic or irritant reaction. Photo-irritant reactions are commonly caused by plants, psoralens, and medications taken internally, whereas photo-allergic reactions are commonly caused by sunscreens and topical nonsteroidal anti-inflammatory medications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12016-018-8696-xDOI Listing
February 2019
39 Reads

Expression of E-cadherin, syndecan 1, Ki-67, and maintenance minichromosome 3 in tissue lesions of actinic prurigo obtained by incisional biopsy.

Indian J Pathol Microbiol 2018 Apr-Jun;61(2):225-227

Department of Stomatology, Institute of Biomedical Sciences, Autonomous University of Ciudad Juarez, Chihuahua, Mexico.

Actinic prurigo (AP) is an idiopathic photodermatosis; the initial manifestations usually occur during the first decades of life but can appear at any age. Cases are usually diagnosed late once the lesions have exacerbated; due to the extensive involvement of the vermilion border and the etiology, it has been confused with and related to a potentially malignant process. Syndecan-1 and E-cadherin were positive in the epidermis, with moderate-to-intense staining in 100% of samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/IJPM.IJPM_574_17DOI Listing
October 2018
29 Reads

A review of photodiagnostic investigations over 26 years: experience of the National Scottish Photobiology Service (1989-2015).

J R Coll Physicians Edinb 2017 Dec;47(4):345-350

H Naasan, Dermatology Department, Ninewells Hospital and Medical School, Dundee, UK. Email:

Background The Scottish Photobiology Service is the national referral pathway for patients with cutaneous photosensitivity diseases in Scotland. We reviewed the pattern of diagnosis of photosensitivity diseases and investigations performed between 1989 and 2015. Methods and Results Data were collected from the Photodiagnostic Database, annual reports and paper records. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4997/JRCPE.2017.408DOI Listing
December 2017

Risk factors associated with actinic prurigo: a case control study.

An Bras Dermatol 2017 Nov-Dec;92(6):774-778

Dermatology Department, Hospital General Dr. Manuel Gea González, Mexico City, Mexico.

Background: Actinic prurigo (AP) is an idiopathic photodermatosis. Although its initial manifestations can appear in 6 to 8-year-old children, cases are diagnosed later, between the second and fourth decades of life, when the injuries are exacerbated.

Objective: To identify risk factors associated with clinical manifestations of AP such as skin and mucosal lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/abd1806-4841.20175105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786389PMC
April 2018
11 Reads

Actinic Prurigo in Scandinavian Adolescent Successfully Treated with Cyclosporine A.

Authors:
Jan C Sitek

Dermatol Reports 2017 Mar 1;9(1):7050. Epub 2017 Jun 1.

Department of Dermatology, Oslo University Hospital, Norway.

Actinic prurigo is a pruritic sun-induced dermatosis classified among the immunologically mediated photodermatoses. The disease is a well-known entity among Native Americans and in Central and South America, however rare in Caucasians with only a few reports from Australia, Britain and France. We report the first case of actinic prurigo in a Scandinavian patient, responding favorably to systemic treatment with cyclosporine A. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4081/dr.2017.7050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661244PMC
March 2017
6 Reads

Polymorphic light eruption and IL-1 family members: any difference with allergic contact dermatitis?

Photochem Photobiol Sci 2017 Sep;16(9):1471-1479

Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana" University of Salerno, Italy.

Polymorphic light eruption (PLE) is described as a delayed-type hypersensitivity reaction (DTHR) toward a de novo light-induced antigen, yet to be identified. In effect, the inflammatory pathways of PLE and allergic contact dermatitis (ACD) share common patterns in terms of the mediators involved from the innate and adaptive immune system participating in the DTHR. As we have previously highlighted the role of interleukin (IL)-1 family members in ACD, we hypothesised that the same mediators could have similar functions in PLE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c7pp00142hDOI Listing
September 2017
19 Reads

Efficacy of a Daily Protective Moisturizer with High UVB and UVA Photoprotection in Decreasing Ultraviolet Damage: Evaluation by Reflectance Confocal Microscopy.

Acta Derm Venereol 2017 Nov;97(10):1196-1201

Melanoma Unit, Dermatology Department, Hospital Clínic and IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain.

Patients with photodermatoses or actinic keratosis benefit from very high ultraviolet B-ultraviolet A (UVB-UVA) photoprotection. However, poor compliance is an issue that jeopardizes adequate protection, leading to disease recurrence. This study evaluated the efficacy of a daily protective moisturizer with high UVB and UVA photoprotection applied 8 h before irradiation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-2736DOI Listing
November 2017
51 Reads

Successful Short Desensitization Treatment Protocol with Narrowband UVB Phototherapy (TL-01) in Polymorphic Light Eruption.

Actas Dermosifiliogr 2017 Oct 23;108(8):752-757. Epub 2017 May 23.

Dermatology Department, Hospital Clínic de Barcelona, Barcelona, Spain.

Introduction: Polymorphic light eruption (PLE) is a common idiopathic photodermatosis that typically presents with pruritic papular or papulovesicular lesions on sun-exposed skin between spring and autumn. In many subjects PLE is mild, and can usually be prevented by the use of broad-spectrum topical sunscreens and a gradual increase in sunlight exposure. However, in some individuals, sunlight exposure results in florid PLE and they often benefit from prophylactic desensitization treatment using phototherapy in early spring, an artificial method that induces a "hardening" phenomenon. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ad.2017.04.004DOI Listing
October 2017
45 Reads

Actinic prurigo as a hypersensitivity reaction type 4.

Int J Dermatol 2017 Jun 27;56(6):e135-e136. Epub 2017 Feb 27.

Dermatology, Dr. Manuel Gea González, General Hospital, Mexico City, Mexico.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijd.13550DOI Listing
June 2017
31 Reads

Photodermatoses: Kids are not just little people.

Clin Dermatol 2016 Nov - Dec;34(6):724-735. Epub 2016 Jul 12.

University of Connecticut School of Medicine, Department of Dermatology, Farmington, CT.

Photodermatoses are a group of skin disorders caused by abnormal reaction to ultraviolet radiation. Photodermatoses are divided into four groups: (1) immunologically mediated photodermatoses; (2) chemical- and drug-induced photodermatoses; (3) photoaggravated dermatoses; and (4) hereditary photodermatoses. This contribution discusses differences in the approach and diagnosis of pediatric and adult patients with suspected photodermatoses, focusing on immunologically mediated photodermatoses and chemical- and drug-induced photodermatoses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clindermatol.2016.07.007DOI Listing
June 2017
25 Reads

Adult-onset actinic prurigo: report of 19 patients from Taiwan.

J Eur Acad Dermatol Venereol 2016 Nov 4;30(11):e140-e142. Epub 2015 Nov 4.

Department of Dermatology and Allergy, Technische Universität München, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.13450DOI Listing
November 2016
13 Reads

Microbial elements as the initial triggers in the pathogenesis of polymorphic light eruption?

Exp Dermatol 2016 12;25(12):999-1001

Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria.

The primary trigger of polymorphic light eruption (PLE) remains to be uncovered. We hypothesize that PLE may be initiated by elements resulting from UV-induced damage to microbial communities of the skin, leading to a cascade of events eventually resulting in the skin rash of the disease. One mechanism by which epidermal injury by UV radiation could trigger PLE are danger signals such as damage or pathogen associated molecular patterns DAMP/PAMPs or commensal-associated molecular patterns (CAMPs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396279PMC
December 2016
6 Reads

Polymorphous light eruption under the Mediterranean sun: a clinico-epidemiological and photobiological study.

Eur J Dermatol 2016 Jun;26(3):304-6

Photobiology Unit, "Andreas Sygros" Hospital for Skin, Venereal Diseases, First Department of Dermatology, University of Athens Medical School, Greece - 5 I Dragoumi Str, 16121 Athens.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/ejd.2016.2751DOI Listing
June 2016
50 Reads

Correlation of serum IgE levels and clinical manifestations in patients with actinic prurigo.

An Bras Dermatol 2016 Jan-Feb;91(1):23-6

Dr. Manuel Gea González General Hospital, Mexico City, Mexico.

Background: Actinic prurigo is an idiopathic photodermatosis, the pathophysiology of which has been hypothesized to involve subtype IV type b (Th2) hypersensitive response, whereby IL4, IL5, and IL13 are secreted and mediate the production of B cells, IgE, and IgG4.

Objectives: To examine the association of serum IgE levels and the clinical severity of injuries.

Methods: This case-control study comprised patients with a clinical and histopathological diagnosis of actinic prurigo, as well as clinically healthy subjects, from whom 3cc of peripheral blood was taken for immunoassay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/abd1806-4841.20163941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782642PMC
October 2016
51 Reads

Actinic Prurigo Cheilitis: A Clinicopathologic Review of 75 Cases.

Am J Dermatopathol 2016 Jun;38(6):418-22

*Department of Pathology, Division of Dermatopathology, Medical College of Wisconsin, Milwaukee, WI; †Hospital General Dr. Manuel Gea Gonzalez, Mexico City, Mexico; Departments of ‡Pathology, and §Dermatology, MD Anderson Cancer Center, Houston TX; ¶Hospital General De Mexico, Mexico City, Mexico; ‖Division of Dermatology and Pathology, Hospital Obrero, La Paz, Bolivia; and **Department of Pathology, Dental School, University of Sao Paulo, Sao Paulo, Brazil.

Actinic prurigo (AP) is a chronic idiopathic photodermatosis that primarily affects American Indians in the United States and Mestizos in Latin American countries. Clinically, the onset of the disease is usually in the first decade of life but may appear initially in adult life, and it is characterized by symmetric involvement of sun-exposed areas of the skin, particularly areas of the face, resulting in polymorphic erythematous papules, macules, and plaques in different stages of evolution. Lower lip involvement includes swelling, scaling, fissures, hyperpigmentation, and ulcerations of the vermilion border. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/DAD.0000000000000459DOI Listing
June 2016
41 Reads

Actinic Prurigo.

Skinmed 2015 Jul-Aug;13(4):287-95; quiz 296. Epub 2015 Aug 1.

Dermatology Department, Hospital General Dr. Manuel Gea González, México DF, Mexico.

Actinic prurigo is an idiopathic photodermatosis that affects the skin, as well as the labial and conjunctival mucosa in indigenous and mestizo populations of Latin America. It starts predominantly in childhood, has a chronic course, and is exacerbated with solar exposure. Little is known of its pathophysiology, including the known mechanisms of the participation of HLA-DR4 and an abnormal immunologic response with increase of T CD4+ lymphocytes. Read More

View Article

Download full-text PDF

Source
March 2016
82 Reads

Characteristics of actinic prurigo in Scotland: 24 cases seen between 2001 and 2015.

Br J Dermatol 2016 Jun 30;174(6):1411-4. Epub 2016 Mar 30.

Photobiology Unit, Department of Dermatology, University of Dundee, Ninewells Hospital & Medical School, Dundee, DD1 9SY, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjd.14444DOI Listing
June 2016
22 Reads

Actinic Prurigo in Singaporean Chinese: A Positive Association with HLA-DRB1*03:01.

Photochem Photobiol 2016 03 11;92(2):355-359. Epub 2016 Feb 11.

National Skin Center, Singapore, Singapore.

Studies have reported the association of human leukocyte antigen (HLA) genes with susceptibility to develop actinic prurigo (AP) in Caucasians, but there were no studies in Asian populations, including the Chinese. Our study was performed to determine if AP is associated with susceptibility or protective HLA alleles or haplotypes in Singaporean Chinese. All Chinese patients diagnosed with AP at National Skin Center, Singapore, from January 2002 to April 2015 were invited to participate in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/php.12569DOI Listing
March 2016
16 Reads

Inmunohistochemical detection of mastocytes in tissue from patients with actinic prurigo.

J Clin Exp Dent 2015 Dec 1;7(5):e656-9. Epub 2015 Dec 1.

Dr. Manuel Gea Gonzalez General Hospital, Dermatology, Mexico City.

Background: Actinic prurigo (AP) is a type of photodermatosis, the pathophysiology of which has not been determined. AP has been suggested to be a hypersensitivity reaction to the presence of eosinophils and the local production of IgE.

Material And Methods: Descriptive study, using paraffin blocks of tissue that have been diagnosed with AP from the Dermopathology department, Hospital General Dr. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4317/jced.52823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663070PMC
December 2015
71 Reads

Apoptosis and apoptotic pathway in actinic prurigo by immunohistochemistry.

Med Oral Patol Oral Cir Bucal 2016 Jan 1;21(1):e53-8. Epub 2016 Jan 1.

Department of Dermatology, Dr. Manuel Gea González General Hospital, Calzada de Tlalpan 4800, Sección XVI Delegación Tlalpan, México, D.F. C.P 14080,

Background: Actinic prurigo (AP) is an idiopathic photodermatosis, this entity requires exposure to UV-B and -A to develop lesions. Apoptosis is a physiological death program that can be initiated by a permanently active mechanism (extrinsic pathway) or irreparable damage (intrinsic pathway).

Material And Methods: Descriptive study, the sample size comprised 64 paraffin blocks of tissue with a diagnosis of AP. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765747PMC
http://dx.doi.org/10.4317/medoral.20765DOI Listing
January 2016
12 Reads

Thalidomide for the treatment of chronic refractory pruritus.

J Am Acad Dermatol 2016 Feb 11;74(2):363-9. Epub 2015 Nov 11.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

Pruritus is a common and often times difficult to treat symptom in many dermatologic and systemic diseases. For pruritus with an inflammatory or autoimmune origin, therapies such as topical corticosteroids and antihistamines are often initiated. However, in the case that these and additional systemic therapies are ineffective, thalidomide, an immunomodulator and neuromodulator, may be a useful alternative treatment. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01909622150223
Publisher Site
http://dx.doi.org/10.1016/j.jaad.2015.09.039DOI Listing
February 2016
53 Reads
4.449 Impact Factor

Oral and Maxillofacial Pathology. Case of the Month. Actinic prurigo.

Tex Dent J 2015 Mar;132(3):168-9, 212-3

View Article

Download full-text PDF

Source
March 2015
7 Reads

The mastocyte: the off switch of UV itch.

Exp Dermatol 2015 Jul;24(7):489-90

Dermatology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/exd.12742
Publisher Site
http://dx.doi.org/10.1111/exd.12742DOI Listing
July 2015
16 Reads

[Interstitial lung disease induced by hydroxychloroquine].

Med Clin (Barc) 2015 Nov 3;145(9):415-6. Epub 2015 Mar 3.

Sección de Neumología, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Tarragona, España.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.medcli.2014.12.022DOI Listing
November 2015
16 Reads

Review of thalidomide use in the pediatric population.

J Am Acad Dermatol 2015 Apr 21;72(4):703-11. Epub 2015 Jan 21.

Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut; Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut.

Thalidomide is resurging in the management of adult rheumatologic skin conditions, especially lupus erythematosus. Although use in pediatric patients is reported since the 1990s, there are no systematic reviews describing treatment in children. Thalidomide has immunomodulatory and anti-tumor necrosis factor-α effects as well as antiangiogenic properties, making it useful for a broad spectrum of inflammatory disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2015.01.002DOI Listing
April 2015
13 Reads

Allergic contact dermatitis to Parthenium hysterophorus mimicking actinic prurigo.

Indian J Dermatol Venereol Leprol 2015 Jan-Feb;81(1):82-4

Department of Dermatology and Venereology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/0378-6323.148594DOI Listing
September 2015
11 Reads

Determination of apoptosis in actinic prurigo by TUNEL technique.

Photodermatol Photoimmunol Photomed 2015 Mar 2;31(2):115-7. Epub 2014 Dec 2.

Oral Pathology Laboratory, National Autonomous University of Mexico, Mexico City, Mexico; Department of Dermatology, Dr. Manuel Gea González General Hospital, Mexico City, Mexico.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/phpp.12153DOI Listing
March 2015
31 Reads

Actinic prurigo of the lip: Two case reports.

World J Clin Cases 2014 Aug;2(8):385-90

Ana MO Miranda, Thiago M Ferrari, Juliana T Werneck, Arley Silva Junior, Karin SG Cunha, Eliane P Dias, Department of Pathology, Federal Fluminense University, Niteroi, Rio de Janeiro 24220-008, Brazil.

Actinic prurigo is a photodermatosis that can affect the skin, conjunctiva and lips. It is caused by an abnormal reaction to sunlight and is more common in high-altitude living people, mainly in indigenous descendants. The diagnosis of actinic prurigo can be challenging, mainly when lip lesions are the only manifestation, which is not a common clinical presentation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12998/wjcc.v2.i8.385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133432PMC
August 2014
23 Reads

Actinic prurigo.

Dermatol Clin 2014 Jul;32(3):335-44, viii

Department of Dermatology, Henry Ford Health System, Henry Ford Medical Center - New Center One, 3031 West Grand Boulevard, Detroit, MI 48202, USA.

Actinic prurigo is a chronic photodermatosis with onset in childhood or before 20 years of age. It is most prevalent in Amerindians and Latin American mestizos, although it has been reported worldwide. Patients present with photodistributed, erythematous excoriated papules, cheilitis, and conjunctivitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.det.2014.03.010DOI Listing
July 2014
9 Reads

Evaluation of patients with photodermatoses.

Dermatol Clin 2014 Jul 5;32(3):267-75, vii. Epub 2014 May 5.

Department of Dermatology, Henry Ford Health System, Henry Ford Hospital, 3031 West Grand Boulevard, Suite 800, Detroit, MI 48202, USA. Electronic address:

The systematic evaluation of photosensitive patients involves a comprehensive history, physical examination, phototesting, and, if necessary, photopatch testing and laboratory evaluation. Polymorphous light eruption, chronic actinic dermatitis, solar urticaria, and photosensitivity secondary to systemic medications are the most commonly encountered photodermatoses in dermatology clinics worldwide. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.det.2014.03.006DOI Listing
July 2014
36 Reads

Photohardening of polymorphic light eruption patients decreases baseline epidermal Langerhans cell density while increasing mast cell numbers in the papillary dermis.

Exp Dermatol 2014 Jun;23(6):428-30

Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria.

The pathogenesis of polymorphic light eruption (PLE) has been linked to a lack of UV-induced immune suppression. To determine the role of Langerhans cells (LC), mast cells and regulatory T cells, biopsies from PLE patients were taken from exposed sites in spring before and after photohardening with 311 nm or PUVA as well as again in summer. Skin sections were assessed for the presence of Langerin/CD1a+ LC and CD3+, CD4+, CD25+ or FoxP3+ T cells and mast cells. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/exd.12427
Publisher Site
http://dx.doi.org/10.1111/exd.12427DOI Listing
June 2014
47 Reads
3 Citations
3.762 Impact Factor

Polymorphous light eruption presenting as pinhead papular eruption on the face.

J Drugs Dermatol 2013 Nov;12(11):1285-6

Polymorphic light eruption (PMLE) is the most common of the immunologically mediated photodermatoses. Onset is typically within the first three decades of life and affects females two to three times more than males. It occurs 30 minutes to 1-3 days after sun exposure and usually resolves in 7 to 10 days. Read More

View Article

Download full-text PDF

Source
November 2013
17 Reads

Clinical characteristics of adult-onset actinic prurigo in Asians: a case series.

Indian J Dermatol Venereol Leprol 2013 Nov-Dec;79(6):783-8

Department of Dermatology, National Skin Centre, Singapore.

Background: Actinic prurigo (AP) is a chronic, pruritic skin condition caused by an abnormal reaction to sunlight.

Aims: The aim of this study is to determine the clinical characteristics of AP in patients attending the National Skin Centre, Singapore, from 1 st January 1999 to 30 th June 2008.

Methods: Cases of AP diagnosed from 1 st January 1999 to 30 th June 2008 were retrieved from the center's electronic medical records and analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/0378-6323.120726DOI Listing
June 2014
23 Reads

Actinic prurigo: a case-control study of risk factors.

Int J Dermatol 2014 Sep 22;53(9):1080-5. Epub 2013 Aug 22.

Department of Dermatology, Dr Manuel Gea González General Hospital, Mexico City, Mexico.

Background: Actinic prurigo (AP) is an idiopathic photodermatosis that usually onsets during childhood and predominates in women. It is characterized by the symmetrical involvement of sun-exposed areas of the skin, lips, and conjunctiva.

Objectives: This study aimed to analyze the risk factors associated with AP using a case-control design. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijd.12168DOI Listing
September 2014
56 Reads

[Current therapeutic indications of thalidomide and lenalidomide].

Med Clin (Barc) 2014 Apr 3;142(8):360-4. Epub 2013 Jul 3.

Servicio de Clínica Médica, Hospital Provincial del Centenario, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Argentina.

Thalidomide is a synthetic glutamic acid derivative first introduced in 1956 in Germany as an over the counter medications. It was thought to be one of the safest sedatives ever produced as it was effective in small doses, was not addictive, and did not have acute side-effects such as motor impairment, but was quickly removed from market after it was linked to cases of severe birth defects. The Food and Drug Administration approved use in the treatment of erythema nodosum leprosum. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.medcli.2013.04.038DOI Listing
April 2014
16 Reads

Update on pediatric photosensitivity disorders.

Authors:
Anna L Grossberg

Curr Opin Pediatr 2013 Aug;25(4):474-9

Department of Dermatology, Johns Hopkins University, Baltimore, Maryland 21287, USA.

Purpose Of Review: Although rare in the pediatric population, photosensitive dermatoses may begin prior to adulthood. The causes of photosensitivity are diverse, ranging from primary, immunologically mediated disorders of photosensitivity to inherited genetic or metabolic disorders. This review will highlight the key features of these disorders to familiarize the pediatric practitioner with their symptoms and any associated extracutaneous clinical or laboratory findings that may accompany them. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOP.0b013e328362c2c3DOI Listing
August 2013
8 Reads

Energy-saving lamps and their impact on photosensitive and normal individuals.

Br J Dermatol 2013 Oct;169(4):910-5

Photobiology Unit, University of Dundee, Ninewells Hospital, Dundee, DD1 9SY, U.K.

Background: A preliminary investigation showed that ultraviolet radiation (UVR) emissions from compact fluorescent lamps (CFLs) can pose a risk to the skin of photosensitive individuals.

Objectives: To carry out a larger-scale study, in patients with a range of photodermatoses, to assess this risk. To determine a safe alternative light source for photosensitive individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjd.12457DOI Listing
October 2013
9 Reads

Impact of photosensitivity disorders on the life quality of children.

Photodermatol Photoimmunol Photomed 2012 Dec;28(6):290-2

Photobiology Unit, Dermatology Centre, School of Translational Medicine, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Manchester, UK.

Background/purpose: Abnormal cutaneous sensitivity to the ultraviolet and/or visible radiation in sunlight characterizes photosensitivity disorders. Little is known regarding their impact in childhood. Our objective was to characterize childhood photosensitivity disorders presenting to a photoinvestigation unit, evaluating their impact on quality of life (QoL). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1600-0781.2012.00691.xDOI Listing
December 2012
18 Reads

Photodermatoses in pigmented skin.

Photochem Photobiol Sci 2013 Jan;12(1):65-77

Department of Dermatology and Venereology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India.

Photodermatoses are a group of skin diseases primarily caused by, or exacerbated by exposure to ultraviolet and or visible radiation. The effect of sunlight on skin depends on a number of factors including skin colour, skin phototype and the content and type of melanin in the skin. There are only a few studies describing photodermatoses in populations with dark skin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c2pp25182eDOI Listing
January 2013
24 Reads

Current knowledge in inflammatory dermatopathology.

Dermatol Clin 2012 Oct 28;30(4):667-84, vii. Epub 2012 Jul 28.

UC Davis Dermatopathology Service, Department of Dermatology, University of California Davis School of Medicine, 3301 C Street, Suite 1400, Sacramento, CA 95816, USA.

The complex and fascinating spectrum of inflammatory skin disease, and the comprehension of it, is ever expanding and evolving. During the first decade of the 21st century, numerous advances in the understanding of inflammatory disease mechanisms have occurred, particularly in psoriasis and atopic dermatitis. Continuation of this trend will assure a future in which molecular tests for biomarkers of immediate clinical relevance are used in routine patient care, not only for diagnosis but also for prognosis and management. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.det.2012.06.004DOI Listing
October 2012
7 Reads

Patients with polymorphic light eruption have decreased serum levels of 25-hydroxyvitamin-D3 that increase upon 311 nm UVB photohardening.

Photochem Photobiol Sci 2012 Dec;11(12):1831-6

Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria.

Background: Polymorphic light eruption (PLE) is a very common condition whose pathogenesis may involve immunological abnormalities. Vitamin D sufficiency is thought to be important for normal immune function.

Objective: To determine whether PLE patients are vitamin D deficient and to study how photohardening with 311 nm UVB affects the vitamin D status of PLE patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c2pp25188dDOI Listing
December 2012
25 Reads