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    Daylight-Mediated Photodynamic Therapy With Methyl Aminolevulinate in Actinic Keratosis Treatment.
    J Cutan Med Surg 2018 Jan 1:1203475417752367. Epub 2018 Jan 1.
    1 Institute of Cosmetic and Laser Surgery, Oakville, ON, Canada.
    Background: Research has shown daylight-mediated photodynamic therapy (PDT) for the treatment of actinic keratosis (AK) to be effective, tolerable, and convenient, with excellent patient satisfaction and cosmesis. Although success has been demonstrated in areas with similar latitudes to Switzerland and Scandinavia, this treatment has not been studied in a Canadian population.

    Objectives: The purpose of this study is to investigate the effectiveness, safety, and patient satisfaction of daylight-mediated methyl 5-aminolevulinate (MAL)-PDT to make recommendations for its use in Canadian practice. Read More

    Histological findings after argon plasma coagulation: an ex-vivo study revealing a possible role in superficial ablative treatment of the skin.
    Arch Dermatol Res 2018 Jan 19. Epub 2018 Jan 19.
    Department of Dermatology, Venereology and Allergology, Dermatologic Surgery Unit, Ruhr-University Bochum, Gudrunstr. 56, 44791, Bochum, Germany.
    Argon plasma coagulation (APC) is an electrosurgical technique which can be used to ablate skin lesions with limited invasion depth into dermal tissue. Hence, APC might be well suited for the removal of epithelial tumours. However, there are no data on the effects of APC on human skin tissue. Read More

    Noninvasive Long-term Monitoring of Actinic Keratosis and Field Cancerization Following Treatment with Ingenol Mebutate Gel 0.015.
    J Clin Aesthet Dermatol 2017 Oct 1;10(10):28-33. Epub 2017 Oct 1.
    Drs. Markowitz, Wang, Levine; Ms. Minhas; and Ms. Schwartz and Ms. Feldman are associated with the Department of Dermatology, SUNY Downstate Medical Center, New York, New York; the Department of Dermatology, Brooklyn VA Harbor Healthcare System, Brooklyn, New York; and the Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York. Dr. Siegel is associated with the Department of Dermatology, SUNY Downstate Medical Center, New York, New York and the Department of Dermatology, Brooklyn VA Harbor Healthcare System, Brooklyn, New York.
    OBJECTIVE: To determine whether actinic keratosis and photodamaged perilesional areas (field cancerization) treated successfully with topical ingenol mebutate gel 0.015% remained clear one year later, and to treat actinic keratosis and perilesional skin not treated one year earlier. DESIGN: Single-center, single-arm, open-label extension of an original clinical study completed one year earlier. Read More

    Dermatologic Lesions Submitted to an Oral and Maxillofacial Pathology Biopsy Service: An Analysis of 2487 Cases.
    Head Neck Pathol 2018 Jan 16. Epub 2018 Jan 16.
    Oral and Maxillofacial Pathology, University of Florida College of Dentistry, 1395 Center Drive, Room D8-6, Gainesville, FL, 32610, USA.
    Skin lesions are often submitted to oral and maxillofacial pathology practices. The purpose of this study is to evaluate the frequency, distribution, variability, and composition of dermatologic lesions within a large oral and maxillofacial pathology biopsy service. An IRB-approved retrospective search of skin lesions diagnosed at University of Florida oral and maxillofacial pathology biopsy service between 1994 and 2015 was performed. Read More

    Noninvasive optical spectroscopy for identification of non-melanoma skin cancer: Pilot study.
    Lasers Surg Med 2018 Jan 13. Epub 2018 Jan 13.
    Division of Head and Neck Surgery and Communication Sciences, Department of Surgery, Duke University Medical Center, Durham, North Carolina.
    Objective: Optical spectroscopy offers a noninvasive alternative to biopsy as a first-line screening tool for suspicious skin lesions. This study sought to define several optical parameters across malignant and benign tissue types.

    Study Design: Prospective pilot trial utilizing the Zenalux IM1 optical spectroscopy device from April 2016 to February 2017. Read More

    Life-Threatening Reaction with Topical 5-Fluorouracil.
    Drug Saf Case Rep 2018 Jan 12;5(1). Epub 2018 Jan 12.
    Linder Dermatology and Skin Cancer Center, 6710 E. Camelback Rd., Suite 220, Scottsdale, AZ, 85251, USA.
    A 67-year-old man developed a suspected adverse drug reaction during treatment with topical 5-fluorouracil (5-FU) for multiple actinic keratosis of the face, neck, and forearms. The man received topical 5-FU at a dosage of 0.5% for the actinic keratoses. Read More

    Daylight Photodynamic Therapy Versus 5-Fluorouracil for the Treatment of Actinic Keratosis: A Case Series.
    Dermatol Ther (Heidelb) 2018 Jan 10. Epub 2018 Jan 10.
    Department of Dermatology, School of Medicine, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
    Introduction: The incidence of actinic keratosis (AK) continues to increase worldwide. Currently available options for the treatment of AK include topical 5-fluorouracil (5-FU) and daylight-mediated photodynamic therapy (DL-PDT). This split-face pilot study compared DL-PDT using 16% methyl aminolevulinate (MAL) cream versus 5-FU cream in patients with AK on the face/scalp. Read More

    Actinic Keratosis and Non-Invasive Diagnostic Techniques: An Update.
    Biomedicines 2018 Jan 8;6(1). Epub 2018 Jan 8.
    Clinica Dermatologica, Policlinico di Modena, Via del Pozzo 70, 41124 Modena, Italy.
    Actinic keratosis represents the earliest manifestation of non-melanoma skin cancer. Because of their risk of progression to invasive squamous cell carcinoma, an earlier diagnosis and treatment are mandatory. Their diagnosis sometimes could represent a challenge even for expert dermatologists. Read More

    5-fluorouracil chemowraps for the treatment of multiple actinic keratoses.
    Eur J Dermatol 2017 Dec;27(6):635-640
    Department of Dermatology, Nantes University Hospital; INSERM U1232, CIC Biothérapie, Nantes, France.
    Few satisfactory treatment options are available for widespread areas affected by multiple actinic keratoses (AKs). Our primary objective was to assess the response rate to weekly 5-fluorouracil (5-FU) chemowraps on widespread AK lesions, and secondarily to assess tolerability, the percentage of patients with recurrence and time to recurrence, the response rate for patients with associated Bowen's disease (BD), and the percentage of squamous cell carcinomas (SCCs) identified after treatment. We conducted an open study which included all the patients who had been treated with weekly 5-FU chemowraps in our department over the course of five years for areas of widespread AKs. Read More

    Prevalence and risk factors of actinic keratosis in patients attending Italian dermatology clinics.
    Eur J Dermatol 2017 Dec;27(6):599-608
    Department of Dermatology, Catholic University of the Sacred Heart, Rome, Italy.
    Actinic keratosis (AK) is a common keratinocyte intra-epidermal neoplasia. To assess AK prevalence and potential risk factors in patients attending Italian general dermatology clinics. This retrospective study was conducted on clinical data from consecutive white outpatients aged ≥30 years, attending 24 general dermatology clinics between December 2014 and February 2015. Read More

    Non Melanoma Skin Cancer Pathogenesis Overview.
    Biomedicines 2018 Jan 2;6(1). Epub 2018 Jan 2.
    Department of Dermatology, Sapienza Università di Roma, Rome 00100, Italy.
    (1) Background: Non-melanoma skin cancer is the most frequently diagnosed cancer in humans. The process of skin carcinogenesis is still not fully understood. However, several studies have been conducted to better explain the mechanisms that lead to malignancy; (2) Methods: We reviewed the more recent literature about the pathogenesis of non-melanoma skin cancer focusing on basal cell carcinomas, squamous cell carcinoma and actinic keratosis; (3) Results: Several papers reported genetic and molecular alterations leading to non-melanoma skin cancer. Read More

    Astragalin attenuates UVB radiation-induced Actinic Keratosis formation.
    Anticancer Agents Med Chem 2017 Dec 29. Epub 2017 Dec 29.
    Affiliated Hospital of Yan'an University Yan'an. China.
    Actinic keratosis (AK), is the most common precancerous skin lesion induced by the excessive ultraviolet B (UVB) and is a significant threat to the public health. UVB exposure causes oxidative DNA damage and is considered to be a significant contributor to AK and subsequent development of skin cancer. Besides, activation of p38 MAPK also plays a significant role in the development of AK. Read More

    Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs.
    ACS Cent Sci 2017 Dec 6;3(12):1276-1285. Epub 2017 Dec 6.
    Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, United States.
    The diterpenoid ester ingenol mebutate (IngMeb) is the active ingredient in the topical drug Picato, a first-in-class treatment for the precancerous skin condition actinic keratosis. IngMeb is proposed to exert its therapeutic effects through a dual mode of action involving (i) induction of cell death that is associated with mitochondrial dysfunction followed by (ii) stimulation of a local inflammatory response, at least partially driven by protein kinase C (PKC) activation. Although this therapeutic model has been well characterized, the complete set of molecular targets responsible for mediating IngMeb activity remains ill-defined. Read More

    Correlation of telomere length to malignancy potential in non-melanoma skin cancers.
    Oncol Lett 2018 Jan 26;15(1):393-399. Epub 2017 Oct 26.
    Department of Dermatology, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
    Telomeres are associated with cell fate and aging through their role in the cellular response to stress and growth stimulation resulting from previous cell divisions and DNA damage. Telomere shortening has been observed in most human cancers, and is known to be a feature of malignancy. The aim of this study is to clarify whether telomere length is related to the malignant potential of non-melanoma skin cancers. Read More

    Treatment of Multiple Actinic Keratosis and Field of Cancerization with Topical Piroxicam 0.8% and Sunscreen 50+ in Organ Transplant Recipients: A Series of 10 Cases.
    Case Rep Dermatol 2017 Sep-Dec;9(3):211-216. Epub 2017 Oct 20.
    Department of Systems Medicine, Division of Dermatology, University of Rome Tor Vergata, Rome, Italy.
    Organ transplant recipient (OTR) subjects are at high risk of skin cancer such as squamous cell carcinoma and basal cell carcinoma. Actinic keratosis (AK) is considered the precursor of these non-melanoma skin cancers. Sun protection is mandatory in subjects with AK and this preventive strategy is very important in OTR. Read More

    A real-world, community-based cohort study comparing the effectiveness of topical fluoruracil vs. topical imiquimod for the treatment of actinic keratosis.
    J Am Acad Dermatol 2017 Dec 22. Epub 2017 Dec 22.
    Division of Research, Kaiser Permanente Northern California, Oakland, CA; Department of Dermatology, Massachusetts General Hospital, and Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA. Electronic address:
    Background: The most widely used topical agents for the field-based treatment of multiple actinic keratoses (AKs) are 5-fluorouracil and imiquimod, but their comparative effectiveness has not been assessed in a real-world setting.

    Objective: We compared the effectiveness of 5-fluorouracil and imiquimod in reducing risk of subsequent AKs in a large, integrated healthcare delivery system in Northern California.

    Methods: In this cohort study, we identified adult health plan members that had an AK diagnosed in 2007 and subsequently filled a prescription for 5-fluorouracil or imiquimod (n=5,700). Read More

    Folliculotropism in pigmented facial macules: Differential diagnosis with Reflectance confocal microscopy.
    Exp Dermatol 2017 Dec 22. Epub 2017 Dec 22.
    Dermatology Department, University of Modena and Reggio Emilia, Italy.
    Pigmented facial macules are common on sun damage skin. The diagnosis of early stage lentigo maligna (LM) and lentigo maligna melanoma (LMM) is challenging. Reflectance confocal microscopy (RCM) has been proven to increase diagnostic accuracy of facial lesions. Read More

    Association between the clinical and histopathological classifications of actinic keratosis and the efficacy of topical imiquimod treatment.
    J Dermatol 2017 Dec 19. Epub 2017 Dec 19.
    Department of Dermatology, Osaka Medical College, Takatsuki, Japan.
    We investigated the association between the clinical and histopathological classifications of actinic keratosis (AK) and the efficacy of topical imiquimod treatment. Forty patients (55 lesions) with AK were treated with topical 5% imiquimod and the efficacy of imiquimod for AK was evaluated based on the clinical/histopathological changes. The complete remission (CR) rates in patients with the different clinical classifications of AK were 85. Read More

    Neoplastic Multifocal Skin Lesions: Biology, Etiology, and Targeted Therapies for Nonmelanoma Skin Cancers.
    Skin Pharmacol Physiol 2017 Dec 21;31(2):59-73. Epub 2017 Dec 21.
    Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Coimbra, Portugal.
    Neoplastic skin lesions are multifocal, diffuse skin infiltrations of particular relevance in the differential diagnosis of ulcerative, nodular, or crusting skin lesions. Nonmelanoma skin cancers (NMSCs), namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and also actinic keratosis (AK), are the most common malignant tumors in humans. BCCs do not proliferate rapidly and most of the times do not metastasize, while SCCs are more infiltrative, metastatic, and destructive. Read More

    Histology of Non-Melanoma Skin Cancers: An Update.
    Biomedicines 2017 Dec 20;5(4). Epub 2017 Dec 20.
    Department of Dermatology, Dipartimento di Medicina Interna e Specialità Mediche, La Sapienza University of Rome, 00161 Rome, Italy.
    Non-melanoma skin cancer (NMSC) is the most frequently diagnosed cancer in humans. Several different non-melanoma skin cancers have been reported in the literature, with several histologic variants that frequently cause important differential diagnoses with other cutaneous tumors basal cell carcinoma (BCC) is the most common malignant skin tumor, with different histologic variants that are associated with a greater or less aggressive behavior and that usually may be confused with other primitive skin tumors. Actinic keratosis, Bowen's disease, keratoacanthoma, and invasive squamous cell carcinoma (SCC) correspond to the other line of NMSC, that may have only local tumoral behavior, easy to treat and with local management (as in the case of actinic keratosis (AK), Bowen's disease, and keratoacanthoma) or a more aggressive behavior with a potential metastatic spread, as in case of invasive SCC. Read More

    Actinic keratosis and diabetes complications: A nationwide population-based study in South Korea (2009-2015).
    Diabetes Metab 2017 Nov 29. Epub 2017 Nov 29.
    Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:
    Aim: As the associations between actinic keratosis (AK) and diabetes complications in patients with diabetes mellitus (DM) have never been investigated, this study aimed to evaluate any such associations in patients with DM.

    Methods: This retrospective cohort study analyzed clinical data for DM patients aged>40 years who had undergone the health examination recommended by the South Korea National Health Insurance Program between 2009 and 2012 (n=2,056,580). All of these patients were classified according to the presence of diabetic retinopathy (DR), end-stage renal disease (ESRD) and history of DVD; myocardial infarction, stroke, transient ischaemic attacks. Read More

    A 12-Day Course of Imiquimod 5% for the Treatment of Actinic Keratosis: Effectiveness and Local Reactions.
    Actas Dermosifiliogr 2017 Dec 12. Epub 2017 Dec 12.
    Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España; Departamento de Piel y Órganos de los Sentidos, Facultad de Medicina, Universidad CEU Cardenal Herrera, Valencia, España.
    Introduction And Objectives: Imiquimod is an excellent option for patients with actinic keratosis, although its use may be limited by the long course of treatment required (4 weeks) and the likelihood of local skin reactions. The objectives of the present study were to demonstrate the effectiveness of a 12-day course of imiquimod 5% for the treatment of actinic keratosis and to examine the association between treatment effectiveness and severity of local reactions.

    Patients And Methods: We included patients with at least 8 actinic keratoses treated with imiquimod 5% cream for 12 consecutive days. Read More

    Management of actinic keratosis at specific body sites in patients at high risk of carcinoma lesions: expert consensus from the AKTeam™ of expert clinicians.
    J Eur Acad Dermatol Venereol 2017 Dec 13. Epub 2017 Dec 13.
    Department of Dermato cancerology, University Hospital Hotel Dieu, Nantes, France.
    Actinic keratoses (AK) arise on sun-exposed regions of the skin. If left untreated, AK may progress to invasive squamous cell carcinoma (SCC), although the rate of progression is low. A practical treatment algorithm for the treatment of AK in standard situations has been published by the AKTeam™ expert panel. Read More

    Two-Step Irradiance Treatment Can Achieve Excellent Pain Control During Red Light 5-Aminolevulinic Acid Photodynamic Therapy for Actinic Keratoses.
    Photomed Laser Surg 2017 Dec 11. Epub 2017 Dec 11.
    3 University of Arizona Cancer Center at Dignity Health St. Joseph's Hospital & Medical Center, Phoenix, Arizona.
    Objective: To evaluate the ability of two-step irradiance to maintain pain control during red light 5-aminolevulinic acid (ALA) photodynamic therapy (PDT) for actinic keratoses (AK) and assess factors influencing pain.

    Background: PDT provides excellent clinical and cosmetic results in the treatment AK and early basal cell carcinomas (BCC). Widespread use of PDT is limited, in part, by pain. Read More

    Opportunities for laser-assisted drug delivery in the treatment of cutaneous disorders.
    Semin Cutan Med Surg 2017 Dec;36(4):192-201
    Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
    Fractional laser-assisted drug delivery (LADD) is increasingly finding its way into clinical practice as a new means to enhance topical drug uptake and improve treatment of cutaneous disorders. To date, LADD has been used for a wide range of conditions, including photodamaged skin, neoplastic lesions, scars, cutaneous infections, and vitiligo as well as for topical anesthetic and aesthetic procedures. Substantiated by randomized controlled clinical trials, strong evidence is available for LADD's usefulness for photodynamic therapy (PDT), for which improved efficacy using laser-assisted photosensitizer treatment is established for actinic keratosis compared with conventional PDT. Read More

    Revisiting lip shave: a solution for disorders of the vermilion border.
    Br J Oral Maxillofac Surg 2018 Jan 6;56(1):60-63. Epub 2017 Dec 6.
    Maxillofacial Unit, Poole Hospital NHS Trust, Dorset BH15 2JB, UK.
    Actinic keratosis, leukoplakia, carcinoma in situ, and superficially invasive carcinomas of the lower lip are caused mainly by the cumulative effects of exposure of the vermilion of the lower lip to ultraviolet radiation. Current treatments all have limitations: cryosurgery or electrosurgery is suitable to treat only focal lesions; topical chemotherapy, which is an option for diffuse actinic damage, yields unreliable results; and laser treatment fails to rejuvenate the vermilion. However, "lip shave", which involves full-thickness excision of the damaged vermilion and reconstruction with an advancement labial mucosal flap, will produce a fresh mucosal lining to the vermilion border. Read More

    White rosettes in discoid lupus erythematosus: a new dermoscopic observation.
    Dermatol Pract Concept 2017 Oct 31;7(4):9-11. Epub 2017 Oct 31.
    BLDE University's Shri M B Patil Medical College, Vijayapura, India.
    White rosettes are shiny white structures seen as four oval-shaped points that come together in the center. They resemble four-leaf clover [1]. Earlier it was thought they were specific for actinic keratosis and squamous cell carcinoma, but they are noted in many other conditions [2]. Read More

    Response to "Phase IV head-to-head randomised controlled trial comparing ingenol mebutate 0.015% gel with diclofenac sodium 3% gel for the treatment of actinic keratosis on the face or scalp" - reply from authors.
    Br J Dermatol 2017 Dec 5. Epub 2017 Dec 5.
    LEO Pharma A/S, Ballerup, Denmark.
    We thank Drs Malvehy and Puig for their comments on the article; our responses follow. Drs Malvehy and Puig correctly note that the primary endpoint is complete clearance at the end of the first treatment course. Here, the rates are 34. Read More

    Response to "Phase IV head-to-head randomised controlled trial comparing ingenol mebutate 0.015% gel with diclofenac sodium 3% gel for the treatment of actinic keratosis on the face or scalp".
    Br J Dermatol 2017 Dec 5. Epub 2017 Dec 5.
    Hospital Clínic Barcelona, Barcelona, Spain& Institud d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.
    We read with attention the recent paper by Stockfleth et al1 on the efficacy and safety of Ingenol Mebutate 0.015% gel (IngMb) vs. diclofenac sodium 3% gel (DS) for the treatment of actinic keratosis (AK). Read More

    Pharmacokinetics and Safety of Ingenol Disoxate Gel Administered Under Maximum-Use Conditions to Patients With Actinic Keratosis.
    Clin Drug Investig 2017 Dec 4. Epub 2017 Dec 4.
    LEO Pharma A/S, Ballerup, Denmark.
    Background And Objectives: Ingenol disoxate (LEO 43204) is a field therapy in development for the treatment of actinic keratosis (AK) on areas between 25 and 250 cm2. We evaluated the systemic exposure and safety of ingenol disoxate under maximum-use conditions.

    Methods: This was a phase I, open-label, non-randomized, multicenter trial. Read More

    Calcipotriol as pretreatment prior to daylight-mediated photodynamic therapy in patients with actinic keratosis: A case series.
    Photodiagnosis Photodyn Ther 2017 Dec 1. Epub 2017 Dec 1.
    Department of Dermatology, School of Medicine, Hospital Italiano de Buenos Aires, Peron 4230, Buenos Aires, 1181, Argentina. Electronic address:
    This split-face design study evaluated the effect of pretreatment with calcipotriol prior to daylight-mediated photodynamic therapy (DL-PDT) in patients with actinic keratosis (AK). The study included 11 subjects with grade I-III AK (mean age: 55 years). Subjects used once-daily calcipotriol 50 mcg/g ointment on half the face/scalp for 15days prior to DL-PDT. Read More

    Clinical and prognostic factors in the development of basal cell carcinoma.
    Clin Dermatol 2017 Nov - Dec;35(6):616-623. Epub 2017 Jul 12.
    Istanbul Training and Research Hospital, Department of Dermatology, Artvin State Hospital, Artvin, Turkey Istanbul, Turkey.
    We investigated the environmental and personal risk factors associated with the development of basal cell carcinoma (BCC). This retrospective cohort study included a total of 997 patients whose diagnosis was confirmed by histopathologic examination between 2007 and 2014. A control examination was performed in 363 of these patients, who were accessed via telephone. Read More

    In vivo Confocal Laser Microscopy for monitoring of actinic keratosis treatment: a comparison with histopathologic assessment after treatment with topical 5% 5-fluorouracil.
    J Eur Acad Dermatol Venereol 2017 Nov 24. Epub 2017 Nov 24.
    Universidade Federal de São Paulo, São Paulo, SP, Brazil.
    Background: Histological examination is the gold standard for actinic keratosis diagnosis; however, it is not always a feasible approach. Reflectance confocal microscopy (RCM) is a non-invasive technique that may be an alternative for monitoring actinic keratoses treatment response. Topical 5-fluorouracil is indicated for actinic keratosis multiple lesions and for field cancerization treatment. Read More

    Induction of Tyrosine Phosphorylation of UV-Activated EGFR by the Beta-Human Papillomavirus Type 8 E6 Leads to Papillomatosis.
    Front Microbiol 2017 10;8:2197. Epub 2017 Nov 10.
    Institute of Virology, University of Cologne, Cologne, Germany.
    Epidemiological evidence is accumulating that beta-human papillomaviruses (HPV) synergize with UV-light in the development of precancerous actinic keratosis, and cutaneous squamous cell carcinomas (cSCC), one of the most common cancers in the Caucasian population. We previously demonstrated the tumorigenic activity of beta-HPV type 8 (HPV8) in the skin of transgenic mice and its cooperation with UV-light. Analysis of underlying mechanisms now showed that in keratinocytes expressing the HPV8E6 protein a transient increase of tyrosine phosphorylated epidermal growth factor receptor (EGFR) in response to UV-irradiation occurred, while EGFR tyrosine phosphorylation, i. Read More

    Application of dynamic thermal imaging in a photocarcinogenesis mouse model.
    Int J Hyperthermia 2017 Dec 5:1-8. Epub 2017 Dec 5.
    a Department of Dermatology , College of Medicine, Korea University , Seoul , Republic of Korea.
    Introduction: In clinical practice and experimental settings, cutaneous premalignant and malignant lesions are commonly diagnosed by histopathological biopsy. However, this technique is invasive and results in functional or cosmetic defects. Dynamic thermal imaging is a non-invasive technique that quantifies the infra-red (IR) radiation emitted by a subject after the introduction of external thermal stimuli (such as heat or cold). Read More

    Immunoreactivity to CYP24A1, but not vitamin D receptor, is increased in mast cells of keratinocyte skin cancers.
    Eur J Dermatol 2017 Dec;27(6):590-598
    Department of Dermatology, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
    In mouse skin models, mast cells have been shown to express vitamin D receptor (VDR) that can mediate the immunosuppressive effects of ultraviolet B radiation and vitamin D3. However, VDR activation leads to the expression of CYP24A1, a hydroxylase that can inactivate vitamin D3 metabolites. To examine immunoreactivity to VDR and CYP24A1 in mast cells from normal human skin, keratinocyte skin cancers, and disorders of chronic inflammation. Read More

    Patient-reported health outcomes in patients with non-melanoma skin cancer and actinic keratosis: results from a large-scale observational study analysing effects of diagnoses and disease progression.
    J Eur Acad Dermatol Venereol 2017 Nov 17. Epub 2017 Nov 17.
    Department of Dermatology and Allergology, Vest Clinic, Recklinghausen, Germany.
    Background: Non-melanoma skin cancer (NMSC) and actinic keratosis (AK) are very common among fair-skinned individuals. A disease continuum from AK to squamous cell carcinoma (SCC) has been frequently postulated. AK and NMSC may influence quality of life (QL) of patients, and it can be suspected that disease progression entails a QL reduction. Read More

    Actinic keratosis area and severity index (AKASI) is associated with the incidence of squamous cell carcinoma.
    J Eur Acad Dermatol Venereol 2017 Nov 8. Epub 2017 Nov 8.
    CentroDerm Clinic, Wuppertal, Germany.
    Background: Actinic keratoses (AKs) are commonly diagnosed clinically. Actinic keratosis area and severity index (AKASI) is a new easy-to-use tool to assess the severity of AKs on the head.

    Objectives: To determine the association between chronically UV-induced tumours such as basal cell carcinomas (BCC) or squamous cell carcinomas (SCC) and AKASI. Read More

    Exploring the use of ingenol mebutate to prevent non-melanoma skin cancer.
    Dan Med J 2017 Nov;64(11)
    Non-melanoma skin cancer is the most frequently occurring cancer in Caucasians today. Incidence rates in Europe have increased steadily since the 1960s and more than tripled over the last 50 years. Despite primary preventative efforts, incidences of non-melanoma skin cancer continue to rise and development of effective chemopreventative strategies is needed. Read More

    Effects of photodynamic therapy on dermal fibroblasts from xeroderma pigmentosum and Gorlin-Goltz syndrome patients.
    Oncotarget 2017 Sep 24;8(44):77385-77399. Epub 2017 Aug 24.
    Department of Biology, Faculty of Sciences, Autónoma University of Madrid, IRYCIS, Madrid, Spain.
    PDT is widely applied for the treatment of non-melanoma skin cancer pre-malignant and malignant lesions (actinic keratosis, basal cell carcinoma and in situ squamous cell carcinoma). In photodynamic therapy (PDT) the interaction of a photosensitizer (PS), light and oxygen leads to the formation of reactive oxygen species (ROS) and thus the selective tumor cells eradication. Xeroderma pigmentosum (XP) and Gorlin-Goltz Syndrome (GS) patients are at high risk of developing skin cancer in sun-exposed areas. Read More

    Nonsyndromic Multiple Basal Cell Carcinomas.
    Arch Craniofac Surg 2017 Sep 26;18(3):191-196. Epub 2017 Sep 26.
    Department of Plastic and Reconstructive Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    Basal cell carcinoma (BCC) comprising several lesions is not uncommon, but nonsyndromic multiple BCCs with parotid invasion are rare entities. We present two cases of multiple sporadic, nonsyndromic BCCs, and one of these cases is a unique case of parotid invasion associated purely with actinic keratosis. In Case 1, a 79-year-old female presented with multiple skin lesions on the face and left hand. Read More

    Daylight photodynamic therapy versus cryosurgery for the treatment and prophylaxis of actinic keratoses of the face - protocol of a multicenter, prospective, randomized, controlled, two-armed study.
    BMC Dermatol 2017 Oct 25;17(1):12. Epub 2017 Oct 25.
    Department of Dermatology, University Hospital Regensburg, 93042, Regensburg, Germany.
    Background: Photodynamic therapy with daylight (DL-PDT) is efficacious in treating actinic keratosis (AK), but the efficacy of field-directed, repetitive DL-PDT for the treatment and prophylaxis of AK in photodamaged facial skin has not yet been investigated.

    Methods/design: In this multicenter, prospective, randomized, controlled, two-armed, observer-blinded trial, patients with a minimum of 5 mild-to-moderate AK lesions on photodamaged facial skin are randomly allocated to two treatment groups: DL-PDT with methyl aminolevulinate (MAL) and cryosurgery. In the DL-PDT group (experimental group), 5 treatments of the entire face are conducted over the course of 18 months. Read More

    Factors influencing response to ingenol mebutate therapy for actinic keratosis of face and scalp.
    World J Clin Oncol 2017 Oct;8(5):405-411
    Dermatology Unit "Daniele Innocenzi", Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04019 Terracina, Italy.
    Aim: To determine factors independently influencing response to ingenol mebutate therapy and assess efficacy on clinical setting of non-hypertrophic non-hyperkeratotic actinic keratosis (AK).

    Methods: Consecutive patients affected by non-hypertrophic non-hyperkeratotic AKs of the face or scalp were enrolled to receive ingenol mebutate 0.015% gel on a selected skin area of 25 cm2 for 3 consecutive days. Read More

    Defining the actinic keratosis field: a literature review and discussion.
    J Eur Acad Dermatol Venereol 2017 Oct 21. Epub 2017 Oct 21.
    Dermatology Unit, Virgen Macarena University Hospital, Seville, Spain.
    Despite the chronic and increasingly prevalent nature of actinic keratosis (AK) and existing evidence supporting assessment of the entire cancerization field during clinical management, a standardized definition of the AK field to aid in the understanding and characterization of the disease is lacking. The objective of this review was to present and appraise the available evidence describing the AK cancerization field, with the aim of determining a precise definition of the AK field in terms of its molecular (including genetic and immunological), histological and clinical characteristics. Eight European dermatologists collaborated to conduct a review and expert appraisal of articles detailing the characteristics of the AK field. Read More

    Topical ALA-PDT as alternative therapeutic option in treatment-recalcitrant dermatosis: Report of 4 cases.
    Photodiagnosis Photodyn Ther 2017 Dec 18;20:189-192. Epub 2017 Oct 18.
    Department of Dermatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address:
    Background: Topical Photodynamic therapy (PDT) is widely acknowledged for its safety and effectiveness in treating oncologic skin diseases such as basal cell carcinoma, actinic keratosis and squamous cell carcinoma in situ. Despite its broad applications in dermatology, this method is a relatively new therapeutic option for treating inflammatory/infectious skin diseases.

    Objectives: To determine whether topical PDT is a safe and effective treatment option in treating treatment-recalcitrant dermatosis. Read More

    Photodynamic therapy leads to significant improvement of actinic keratosis area and severity index (AKASI).
    Photodiagnosis Photodyn Ther 2017 Oct 16. Epub 2017 Oct 16.
    CentroDerm Clinic, Heinz-Fangman-Straße 57, Wuppertal, Germany; Faculty of Health, University Witten-Herdecke, Alfred-Herrhausen-Straße 50, Witten, Germany.
    Background: Actinic keratosis area and severity index (AKASI) is a new quantitative tool for assessing AK severity on the head and can be used to monitor outcomes of different therapies. The aim of this study was to determine treatment outcomes of AK applying AKASI three months after conventional photodynamic therapy (PDT).

    Methods: We performed a retrospective analysis of patients who have undergone PDT on the head and had a documented AKASI evaluation prior to PDT and at follow-up visits. Read More

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