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    Swiss (German) Version of the Actinic Keratosis Quality of Life questionnaire.
    Dermatology 2018 Apr 18. Epub 2018 Apr 18.
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    Background: Actinic keratosis (AK) is a sun-induced skin lesion that may progress to invasive squamous cell carcinoma of the skin. Recently, the Actinic Keratosis Quality of Life questionnaire (AKQoL) was designed for patients with AK in Denmark as a specific quality of life instrument for AK patients.

    Objective: The objective of this study was to adapt the AKQoL for the German language region of Switzerland and to evaluate its psychometric properties (validity, reliability). Read More

    Comparison of 10 efficient protocols for photodynamic therapy of actinic keratosis: How relevant are effective light dose and local damage in predicting the complete response rate at 3 months?
    Lasers Surg Med 2018 Apr 18. Epub 2018 Apr 18.
    Univ. Lille, INSERM, CHU Lille, U1189-ONCO-THAI-Image Assisted Laser Therapy for Oncology, Lille, F-59000, France.
    Background: Topical photodynamic therapy is an established treatment modality for various dermatological conditions, including actinic keratosis. In Europe, the approved protocols for photodynamic therapy of actinic keratosis involve irradiation with either an Aktilite CL 128 lamp or daylight, whereas irradiation with the Blu-U illuminator is approved in the United States. Many other protocols using irradiation by a variety of light sources are also clinically efficient. Read More

    Differential proteomic analysis of actinic keratosis, Bowen's disease and cutaneous squamous cell carcinoma by label-free LC-MS/MS.
    J Dermatol Sci 2018 Apr 10. Epub 2018 Apr 10.
    Centre for Translational Skin Research, The University of Sydney, Westmead, New South Wales, 2145, Australia; Department of Dermatology, Westmead Hospital, Westmead, New South Wales, 2145, Australia. Electronic address:
    Background: The boundaries between actinic keratosis (AK), Bowen's disease (BD), and cutaneous squamous cell carcinoma (cSCC) are sometimes not clear. Large-scale proteomic profiling studies of these lesions are also non-existent.

    Objective: To evaluate proteomic changes between normal epidermis, AK, BD and cSCC that could support a molecular classification and improve our understanding of disease progression. Read More

    Comparison of Blue and White Lamp Light with Sunlight for Daylight-Mediated, 5-ALA Photodynamic Therapy, in vivo.
    Photochem Photobiol 2018 Apr 16. Epub 2018 Apr 16.
    Thayer School of Engineering, Dartmouth College, Hanover, NH, 03755.
    Daylight-mediated photodynamic therapy (d-PDT) as a treatment for actinic keratosis (AK) is an increasingly common technique due to a significant reduction in pain, leading to better patient tolerability. While past studies have looked at different light sources and delivery methods, this study strives to provide equivalent PpIX-weighted light doses with the hypothesis that artificial light sources could be equally as effective as natural sunlight if their PpIX-weighted fluences were equalized. Normal mouse skin was used as the model to compare blue LED light, metal halide white light, and natural sunlight, with minimal incubation time between topical ALA application and the onset of light delivery. Read More

    Conjunctival Lesions: When Should We Perform Biopsy?
    Nepal J Ophthalmol 2017 Jul;9(18):160-169
    Introduction: The conjunctiva is a thin and flexible mucus membrane that provides a protective barrier for the eye. Very few histopathologic studies have been conducted on biopsies from conjunctival lesions (CL) in central India.

    Objective: To study the spectrum of CL and define those lesions that need attention with regard to need of biopsy in order to prevent grave sequelae and ocular morbidity. Read More

    A new dermoscopic algorithm for the differential diagnosis of facial lentigo maligna and pigmented actinic keratosis.
    Eur J Dermatol 2018 Apr 5. Epub 2018 Apr 5.
    Institute of Dermatology, Catholic University of Rome, Rome, Italy.
    The clinical and dermoscopic diagnosis of facial lentigo maligna (LM) and pigmented actinic keratosis (PAK) remains challenging, particularly at the early disease stages. To identify dermoscopic criteria that might be useful to differentiate LM from PAK, and to elaborate and validate an automated diagnostic algorithm for facial LM/PAK. We performed a retrospective multicentre study to evaluate dermoscopic images of histologically-proven LM and PAK, and assess previously described dermoscopic criteria. Read More

    A Rare Presentation of Actinic Keratosis Affecting the Tarsal Conjunctiva and Review of the Literature.
    Case Rep Ophthalmol Med 2018 12;2018:4375354. Epub 2018 Feb 12.
    Ophthalmology Department, Great Western Hospital, Swindon, UK.
    We report an unusual case of actinic keratosis (AK) of the tarsal conjunctiva in a 63-year-old man. Examination revealed a crusty, leukoplakic lesion prone to bleeding on the tarsal conjunctiva of the right upper eyelid. This was treated by surgical excisional biopsy. Read More

    Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361).
    J Med Chem 2018 Apr 17. Epub 2018 Apr 17.
    Athenex Inc. , Conventus Building, 1001 Main Street, Suite 600 , Buffalo , New York 14203 , United States.
    The discovery of potent, peptide site directed, tyrosine kinase inhibitors has remained an elusive goal. Herein we describe the discovery of two such clinical candidates that inhibit the tyrosine kinase Src. Compound 1 is a phase 3 clinical trial candidate that is likely to provide a first in class topical treatment for actinic keratosis (AK) with good efficacy and dramatically less toxicity compared to existing standard therapy. Read More

    Commentary on the "Evidence- and Consensus-Based (S3) Guidelines for the Treatment of Actinic Keratosis" Published by the International League of Dermatological Societies in Cooperation with the European Dermatology Forum.
    Skin Pharmacol Physiol 2018 Apr 3;31(3):144-146. Epub 2018 Apr 3.
    Department of Dermatology and Allergology, Clinic Vest, Recklinghausen, Germany.
    In 2015, the International League of Dermatological Societies and the European Dermatology Forum published a guideline for the treatment of actinic keratosis, which is classified as an evidence- and consensus-based S3 guideline. From the point of view of the GD Task Force "Licht.Hautkrebs. Read More

    Protoporphyrin IX formation after application of methyl aminolevulinate on the face and scalp with and without prior curettage.
    Photodiagnosis Photodyn Ther 2018 Mar 27. Epub 2018 Mar 27.
    Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Denmark.
    Background: Pulse photodynamic therapy (PDT) is carried out as classical PDT except that methyl aminolaevulinate (MAL) is removed after 30 min. Protoporphyrin IX (PpIX) accumulation becomes lower after 3 h in pulse-PDT than in classical PDT, but pulse-PDT still has full treatment effect on actinic keratosis (AK). The present study aimed to investigate when PpIX formation in classical PDT without curettage reaches the PpIX level in pulse-PDT with curettage in the skin of the face and scalp. Read More

    Photodynamic therapy for esthetic-cosmetic indications.
    G Ital Dermatol Venereol 2018 Mar 29. Epub 2018 Mar 29.
    Hautzentrum Köln (Cologne Dermatology), Cologne, Germany -
    Photodynamic therapy (PDT) is a well-established, non-invasive treatment for a variety of dermatologic disorders, including actinic keratosis. Furthermore, PDT results in marked improvements in the signs of skin aging, although currently there are no standardized guidelines for PDT in skin rejuvenation. Two types of PDT are available: conventional-PDT (c-PDT) and the newly introduced daylight-PDT (DL-PDT). Read More

    Field Cancerization Therapies for Management of Actinic Keratosis: A Narrative Review.
    Am J Clin Dermatol 2018 Mar 26. Epub 2018 Mar 26.
    Department of Dermatology, University of Illinois College of Medicine, 808 S. Wood St., Suite 380, Chicago, IL, 60612, USA.
    Actinic keratoses (AKs) are atypical, precancerous proliferations of keratinocytes that develop because of chronic exposure to ultraviolet (UV) radiation. Treatment of AK can be lesion-directed or field-directed. Field cancerization theory postulates that the skin surrounding AK is also at increased risk for possible malignant transformation since it has been exposed to the same chronic UV light. Read More

    Various Cold Plasma Devices for the Treatment of Actinic Keratosis.
    J Eur Acad Dermatol Venereol 2018 Mar 26. Epub 2018 Mar 26.
    C&J Nyheim Plasma Institute, Drexel University, 200 Federal Street, Suite 500, Camden, NJ, 08103.
    We have read with interest the letter entitled "Actinic keratoses treated with cold atmospheric plasma" by Wirtz et al. and we are glad to see that other dermatologists are corroborating our February, 2017 report on the use of cold plasma to treat actinic keratoses. We hope this will encourage the use of plasma for other clinical indications. Read More

    Actinic keratosis area severity index (AKASI): Reproducibility study and comparison with total lesion count.
    Br J Dermatol 2018 Mar 23. Epub 2018 Mar 23.
    Centroderm Clinic, Wuppertal, and Faculty of Health, University Witten-Herdecke, Witten, Germany.
    Actinic keratosis (AK) is caused by ultraviolet radiation exposure and is more likely to be subclinical than visible. AK can potentially progress to invasive squamous cell carcinoma (SCC). All stages of AK and sometimes, invasive SCC coexist in the "cancerization field" where further neoplastic changes can occur. Read More

    Outpatient Dermatological Diagnoses in Spain: Results From the National DIADERM Random Sampling Project.
    Actas Dermosifiliogr 2018 Mar 20. Epub 2018 Mar 20.
    Servicio de Dermatología, Complejo Hospitalario de Vigo, Vigo, España; Unidad de Investigación, Fundación Piel Sana AEDV, Madrid, España.
    Introduction: Dermatologists perform most of their work in outpatient or private clinics. Data on the diagnoses made by dermatologists in these settings are lacking, however, as outpatient activity, unlike hospital activity, is difficult to code. The aim of this study was to analyze the diagnoses made by members of the Spanish Academy of Dermatology and Venereology (AEDV) at dermatology clinics in Spain. Read More

    Epidemiology of skin cancer in the mature patient.
    Clin Dermatol 2018 Mar - Apr;36(2):167-176. Epub 2017 Oct 13.
    Sinclair Dermatology, East Melbourne, VIC Australia; Faculty of Medicine, The University of Melbourne, Parkville, VIC Australia. Electronic address:
    Epidermal cancers include keratinocyte cancer, melanocyte cancer, and Merkel cell carcinoma. These cancers account for the vast majority of new cancers diagnosed in Australia, North America, and Europe. Keratinocyte cancer is the most common epidermal cancer and accounts for 7 out of 8 new cancers diagnosed in Australia. Read More

    Parkinson's Disease, Melanoma, and Keratinocyte Carcinoma: A Population-Based Study.
    Neuroepidemiology 2018 Mar 22;50(3-4):168-173. Epub 2018 Mar 22.
    Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
    Background: The association between Parkinson's disease (PD) and melanoma is well recognized, but its relationship with non-melanoma skin cancers has not been studied in depth.

    Objective: To assess the relationship between PD, and risk of melanoma and keratinocyte carcinoma: squamous cell carcinoma (SCC) and basal cell carcinoma (BCC).

    Methods: This historical cohort study used the data of 1. Read More

    [Gout or squamous cell cancer of the ear in a 91-year-old man - diagnostic and therapeutic problems: a case report].
    Wiad Lek 2018 ;71(1 pt 1):88-92
    Zakład Onkologii, Uniwersytet Medyczny w Lublinie, Lublin, Polska.
    Gout tophi around auricular area are common in old men. The differential diagnosis of papules or nodules on the ear includes tophaceous gout, rheumatoid nodules, basal or squamous cell cancer, melanoma, verruca vulgaris or actinic keratosis. The presence of the skin cancer, most commonly located on the head and neck, is often related to the long exposure of the skin to sunlight. Read More

    Prolonged voriconazole treatment in a patient with chronic lymphocytic leukemia resulting in a litany of chronic overlapping toxicities.
    J Oncol Pharm Pract 2018 Jan 1:1078155218762624. Epub 2018 Jan 1.
    2 Department of Infectious Diseases Infection Control and Employee Heath, MD Anderson Cancer Center, The University of Texas Houston, TX, USA.
    Voriconazole is a triazole antifungal with activity against a number of yeast and mold species including Candida, Aspergillosis, Fusarium, and Coccidioides. Invasive fungal infections are associated with high morbidity and mortality, prolonged treatment courses, and occasionally lifelong suppressive therapy. Voriconazole therapy can result in a number of acute toxicities that clinicians are frequently aware of including hepatotoxicity, visual disturbances, and hallucinations; however, there is limited experience with extended durations of voriconazole therapy. Read More

    Phototherapy with Light Emitting Diodes: Treating a Broad Range of Medical and Aesthetic Conditions in Dermatology.
    J Clin Aesthet Dermatol 2018 Feb 1;11(2):21-27. Epub 2018 Feb 1.
    Dr. Ablon is with the Ablon Skin Institute and Research Center in Manhattan Beach, California.
    Within the field of dermatology, advances in the use of light emitting diodes (LEDs) have led to their clinical application for a variety of medical and cosmetic uses. Of note, one phototherapy device has demonstrated beneficial effects over a range of clinical applications (Omnilux™; GlobalMed Technologies, Glen Ellen, California). The study included a literature review of published studies. Read More

    [Chronic ulceration of the hand in a mechanic: epidermoid carcinoma should be suspected].
    Pan Afr Med J 2017 14;28:141. Epub 2017 Oct 14.
    Service de Dermatologie et Vénérologie, Centre Hospitalier Universitaire IBN Sina, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.
    Cutaneous squamous cell carcinoma is a malignant tumor developed from the epidermis or the squamous mucosa. It may occur de novo or, most often, on precancerous lesions, including actinic keratoses. This tumor can sometimes be secondary to physical or chemical hazardous conditions encountered during the professional activity. Read More

    Efficacy and safety of topical SR-T100 gel in treating actinic keratosis in Taiwan: A Phase III randomized double-blind vehicle-controlled parallel trial.
    J Dermatol Sci 2018 Mar 2. Epub 2018 Mar 2.
    Department of Dermatology, Kaohsiung Medical University Hospital and College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:
    Background: Currently available topical treatments for actinic keratosis (AK) are associated with substantial side-effects.

    Objectives: To evaluate the efficacy and safety of topical SR-T100 gel in treating AK.

    Methods: A multicenter, randomized, double-blinded phase III trial was conducted. Read More

    Cutaneous squamous cell carcinomas are associated with basal proliferating actinic keratoses.
    Br J Dermatol 2018 Mar 11. Epub 2018 Mar 11.
    CentroDerm Clinic, Heinz-Fangman-Straße 57, Wuppertal, Germany.
    Background: In addition to the extent of atypical keratinocytes throughout the epidermis, actinic keratoses (AKs) are histologically characterized by downward directed basal layer expansion. It is not known if this growth pattern correlates with the risk of developing invasive squamous cell carcinoma (iSCC).

    Objective: To characterize the prevalence of downward directed basal layer expansion of AKs adjacent to iSCC. Read More

    Impact of topical fluorouracil cream on costs of treating keratinocyte carcinoma (nonmelanoma skin cancer) and actinic keratosis.
    J Am Acad Dermatol 2018 Mar 2. Epub 2018 Mar 2.
    Center for Dermatoepidemiology, Department of Veterans Affair Medical Center, Providence, Rhode Island; Department of Dermatology, Brown University, Providence, Rhode Island; Department of Epidemiology, Brown University, Providence, Rhode Island; Department of Dermatology, Rhode Island Hospital, Providence, Rhode Island.
    Background: It is unknown whether treatment costs for keratinocyte carcinoma (KC) and actinic keratosis (AK) can be lowered by spending more on chemoprevention.

    Objective: To examine the impact of 1-course treatment with topical fluorouracil (5-FU) on the face and ears on KC and AK treatment costs over 3 years.

    Methods: The Veterans Affairs Keratinocyte Carcinoma Chemoprevention trial compared the efficacy of topical 5-FU 5% with that of vehicle control cream for reducing KC risk. Read More

    The depth of follicular extension in actinic keratosis correlates with the depth of invasion in squamous cell carcinoma: implication for clinical treatment.
    J Eur Acad Dermatol Venereol 2018 Feb 28. Epub 2018 Feb 28.
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
    Background: Actinic keratosis (AK) may show extension down follicles, not only in cases with full-thickness epidermal atypia ('bowenoid' AK), but also in cases with atypia limited to the epidermal basalis. Previous studies have demonstrated that, in bowenoid AK, follicular extension is usually superficial, being limited to the upper follicular segment. Little is known about the depth of follicular involvement in cases of invasive squamous cell carcinoma of the skin (iSCC) arising from AK and the role of the follicle in iSCC pathogenesis. Read More

    Human Papillomavirus as a Potential Risk Factor for Oral Premalignant Lesions.
    Acta Clin Croat 2017 Sep;56(3):369-374
    Institute of Public Health, Skopje, Republic of Macedonia.
    Oral premalignant lesions (OPLs) and numerous alterations of oral mucosa remain unsolved due to their complex etiopathogenesis. Human papillomaviruses (HPVs), in particular, have been reported as the possible risk factors or cofactors. The aim of the study was to determine the association of different HPV types with oral premalignant lesions, and the potential role of smoking and alcohol use. Read More

    Clinical forms of actinic keratosis and levels of dysplasia of the epidermis.
    Wiad Lek 2017 ;70(6 pt 1):1072-1078
    State Scientific Institution "Research and Practical Centre of Preventive and Clinical Medicine" of the State Administration, Kyiv, Ukraine, Oleksandrivska City Clinical Hospital, Kyiv, Ukraine.
    Objective: Introduction: Actinic keratosis (AK) is precancerous skin lesion that occurs in the sun-exposedskin areas characterized by local intraepidermal dysplasia of different severity (KIN I, KIN II and KIN III). The aim of this research was to study distribution patterns and morphological features of AK histological types.

    Patients And Methods: Materials and Methods: The study included skin biopsy material from 68 patients with different clinical forms of AK. Read More

    Quality of Life, Behaviour and Attitudes towards Actinic Keratosis in Spain: The PIQA Study.
    Actas Dermosifiliogr 2018 Feb 21. Epub 2018 Feb 21.
    Instituto Valenciano de Oncología, Valencia, España. Electronic address:
    Objective: This study was aimed to examine patients' knowledge, behaviours and attitudes regarding actinic keratosis (AK) lesions and the impact of the disease on patients' quality of life (QoL).

    Methods: Observational study of patients with AK lesions in Spain. QoL was evaluated with the validated version of Spanish AKQoL questionnaire. Read More

    A randomized split-scalp study comparing Calcipotriol assisted MAL-PDT with Conventional MAL-PDT for the treatment of Actinic Keratosis.
    Br J Dermatol 2018 Feb 24. Epub 2018 Feb 24.
    Department of Dermatology and Allergology, Klinikum Vest GmbH, Recklinghausen, Germany.
    Background: Topical photodynamic therapy (PDT) is an approved treatment for actinic keratosis (AK). To enhance the efficacy of PDT for AKs, physical (ablative lasers and microneedling) and chemical (pro-differentiating drugs) pretreatments have been suggested.

    Objectives: To compare the efficacy and safety of the combination of topical calcipotriol (CAL) before methylaminolevulinate (MAL)-PDT for AKs of the scalp versus conventional MAL-PDT in a randomized controlled-clinical trial. Read More

    Optical coherence tomography for the diagnosis of malignant skin tumors: a meta-analysis.
    J Biomed Opt 2018 Feb;23(2):1-10
    Southern Medical University, School of Public Health, Guangdong Provincial Key Laboratory of Tropica, China.
    Optical coherence tomography (OCT) is an emergent imaging tool used for noninvasive diagnosis of skin diseases. The present meta-analysis was carried out to assess the accuracy of OCT for the diagnosis of skin cancer. We conducted a systematic literature search though EMBASE, Medline, PubMed, the Cochrane Library, and Web of Science database for relevant articles published up to June 6, 2017. Read More

    Inflamed actinic keratoses associated with pemetrexed and carboplatin therapy.
    Dermatol Online J 2017 Oct 15;23(10). Epub 2017 Oct 15.
    Boston University School of Medicine, Boston, Massachusetts.
    Eruptive actinic keratosis (AK) consequent to systemic chemotherapy can be confused with drug allergies. We present the first case of inflamed AKs in one patient after receiving combination therapy with pemetrexed and carboplatin.A 68-year-old woman with non-small cell lung adenocarcinoma (NSCLC) presented with numerous pruritic ill-defined, gritty, erythematous papules consistent with AKs on her upper chest, upper back, and arms two weeks after completing the first cycle of combination therapy with carboplatin and pemetrexed. Read More

    Local skin reactions following the administration of topical ingenol mebutate for actinic keratosis.
    Dermatol Online J 2017 Sep 15;23(9). Epub 2017 Sep 15.
    Dermatology Department, Hospital Clínico San Carlos, Madrid, Spain.
    Actinic keratoses are cutaneous lesions that appear as the result of the proliferation of atypical keratinocytes. These lesions are considered pre-malignant and they can progress to squamous cell carcinoma. Ingenol mebutate has been approved as an effective treatment for AK on the face and trunk. Read More

    PHOTODYNAMIC TREATMENT WITH NANOEMULSIFIED 5-AMINOLEVULINIC ACID AND NARROW BAND RED LIGHT FOR FIELD CANCERIZATION DUE TO OCCUPATIONAL EXPOSURE TO ULTRAVIOLET LIGHT IRRADIATION.
    Georgian Med News 2018 Jan(274):138-143
    Department of Dermatology and Allergology, Academic Teaching Hospital Dresden, Dresden, Germany.
    Actinic keratosis (AK) is a premalignant epithelial disease that develops on skin chronically exposed to ultraviolet-light. For outdoor workers, AK is an occupational hazard with a potential for malignant transformation into squamous cell carcinoma. Various topical treatments are used to treat AK's. Read More

    A patient case highlighting the myriad of cutaneous adverse effects of prolonged use of hydroxyurea.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    Division of Dermatology, University of Kansas Medical Center, Kansas City, Kansas.
    Background: Hydroxyurea is an antimetabolite primarily used to treat myeloproliferative disorders, and chronic treatment is associated with many cutaneous adverse effects ranging in severity from ichthyosis to aggressive nonmelanoma skin cancer.

    Case Presentation: We report a 67-year-oldman with a history of polycythemia vera who was referred for management of progressively worsening dorsal hand lesions. The patient presented withhyperpigmentation, ichthyosis, plantar keratoderma, dermatomyositis-like eruptions, two squamous cell carcinomas, and actinic keratoses. Read More

    Cost-efficacy analysis of 3% diclofenac sodium, ingenol mebutate, and 3.75% imiquimod in the treatment of actinic keratosis.
    Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418757925
    3 School of Pharmacy and Nutraceuticals, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
    Actinic keratosis (AK) is a clinical condition characterized by keratinocytic dysplastic lesions of the epidermis, affecting individuals chronically exposed to sunlight. Topical therapies allow the treatment of a whole area of affected skin and currently include diclofenac sodium gel, 5-fluorouracil cream, 5-fluorouracil and acetylsalicylic acid solution, imiquimod cream, and ingenol mebutate gel. Due to the comparable efficacy of 3% diclofenac, ingenol mebutate, and 3. Read More

    Tobacco Pouch Keratosis in a young individual: A brief description.
    J Indian Soc Periodontol 2017 May-Jun;21(3):249-251
    Department of Pedodontics, Melaka-Manipal Medical College, Malacca, Malaysia.
    Smokeless tobacco is used orally or nasally without burning tobacco. This is equally harmful as smokers due to the tobacco content and can cause oral cancer as well as systemic effects such as nicotinic dependence. Many other oral conditions have also been reported in association with smokeless tobacco. Read More

    Classification of the Clinical Images for Benign and Malignant Cutaneous Tumors Using a Deep Learning Algorithm.
    J Invest Dermatol 2018 Feb 8. Epub 2018 Feb 8.
    Department of Dermatology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. Electronic address:
    We tested the use of a deep learning algorithm to classify the clinical images of 12 skin diseases-basal cell carcinoma, squamous cell carcinoma, intraepithelial carcinoma, actinic keratosis, seborrheic keratosis, malignant melanoma, melanocytic nevus, lentigo, pyogenic granuloma, hemangioma, dermatofibroma, and wart. The convolutional neural network (Microsoft ResNet-152 model; Microsoft Research Asia, Beijing, China) was fine-tuned with images from the training portion of the Asan dataset, MED-NODE dataset, and atlas site images (19,398 images in total). The trained model was validated with the testing portion of the Asan, Hallym and Edinburgh datasets. Read More

    Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin.
    Nat Commun 2018 02 8;9(1):577. Epub 2018 Feb 8.
    Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, 69120, Heidelberg, Germany.
    Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and usually progresses from a UV-induced precancerous lesion termed actinic keratosis (AK). Despite various efforts to characterize these lesions molecularly, the etiology of AK and its progression to cSCC remain partially understood. Here, we use Infinium MethylationEPIC BeadChips to interrogate the DNA methylation status in healthy, AK and cSCC epidermis samples. Read More

    Evaluation of T-lymphocyte subpopulations in actinic keratosis, in situ and invasive squamous cell carcinoma of the skin.
    J Cutan Pathol 2018 May 14;45(5):337-347. Epub 2018 Mar 14.
    Department of Pathology, School of Medicine, University of Patras, Patras, Greece.
    Background: Tumor infiltrating lymphocytes (TILs) represent important regulators of carcinogenesis. Cutaneous invasive squamous cell carcinoma (inSCC) develops through precursor lesions, namely in situ squamous cell carcinoma (isSCC) and actinic keratosis (AK), representing a natural model of carcinogenesis. The study evaluates TIL subpopulations in inSCC and its precursors by comparing 2 semiquantitative scoring systems, and assesses the presence of regulatory T-cells (Tregs) in these lesions. Read More

    Can daylight-PDT be performed indoor?
    G Ital Dermatol Venereol 2018 Feb 7. Epub 2018 Feb 7.
    Université de Lille, Inserm, CHU Lille, U1189, ONCO-THAI, Image Assisted Laser Therapy for Oncology, Lille, France.
    Natural DayLight-mediated PhotoDynamic Therapy (NDL-PDT) is an efficacious treatment option for thin actinic keratosis that offers advantages over conventional PDT in terms of tolerability, treatment duration, and cost. It is now accepted that the minimum criteria required for effective NDL-PDT is a dose of 4 J/cm2 with a treatment time of 2 h and a minimum temperature of 10°C, corresponding to a minimum illuminance of 11 000 lux. This value is easily achievable: 20 000 lux can be obtained during a typical overcast day at midday. Read More

    Photodynamic Therapy Activated by Intense Pulsed Light in the Treatment of Nonmelanoma Skin Cancer.
    Biomedicines 2018 Feb 7;6(1). Epub 2018 Feb 7.
    Skin Center, Dermo-Aesthetic Lasers Centers, 67051 Avezzano, Italy.
    Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) has proven to be a highly effective conservative method for the treatment of actinic keratosis (AK), Bowen's disease (BD), and superficial basal cell carcinoma (sBCC). PDT is traditionally performed in association with broad-spectrum continuous-wave light sources, such as red or blue light. Recently, intense pulsed light (IPL) devices have been investigated as an alternative light source for PDT in the treatment of nonmelanoma skin cancers (NMSC). Read More

    Topical formulations of delta-aminolevulinic acid for the treatment of actinic keratosis: Characterization and efficacy evaluation.
    Eur J Pharm Sci 2018 Mar 31;115:345-351. Epub 2018 Jan 31.
    Department of Chemistry, University of Florence, via U. Schiff 6, 50019 Sesto Fiorentino, (FI), Italy. Electronic address:
    Actinic keratosis (AK) is a pre-cancerous disease, with worldwide increasing incidence, which consists in squamous cutaneous lesion caused by excessive exposure to ultraviolet radiation. An established treatment option is photodynamic therapy (PDT), based on light, oxygen and a photosensitizer. The most widely used is 5-aminolevulinic acid (ALA) which however, being a hydrophilic molecule, has difficultly penetrating the skin to achieve the desired therapeutic effect. Read More

    Three-day Field Treatment with Ingenol Disoxate (LEO 43204) for Actinic Keratosis: A Phase II Trial.
    J Clin Aesthet Dermatol 2017 Dec 1;10(12):19-26. Epub 2017 Dec 1.
    Dr. Siegel is with Long Island Skin Cancer and Dermatologic Surgery in New York, New York.
    The purpose of this study was to evaluate the safety and efficacy of ingenol disoxate gel using a once-daily, three-day field treatment regimen in patients with actinic keratosis. This was a Phase II, multicenter, open-label trial (clinicaltrials.gov: NCT02305888). Read More

    Three-Day Field Treatment with Ingenol Disoxate (LEO 43204) for Actinic Keratosis: Cosmetic Outcomes and Patient Satisfaction from a Phase II Trial.
    J Clin Aesthet Dermatol 2017 Nov 1;10(11):26-32. Epub 2017 Nov 1.
    Dr. Berman is Co-Director at Center for Clinical and Cosmetic Research in Aventura, Florida.
    To report cosmetic outcomes and patient satisfaction with ingenol disoxate (LEO 43204) used in a once-daily, three-day field treatment regimen in patients with actinic keratosis. This was a phase II, multicenter, open-label trial (ClinicalTrials.gov: NCT02305888) involving 20 trial sites in the United States. Read More

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