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    3213 results match your criteria Actinic Keratosis

    1 OF 65

    [New approaches for the prevention of actinic keratosis].
    Hautarzt 2017 Apr 25. Epub 2017 Apr 25.
    IUF - Leibniz-Institut für umweltmedizinische Forschung, Auf'm Hennekamp 50, 40225, Düsseldorf, Deutschland.
    Actinic keratosis is one of the most common skin diseases. Because of the ongoing demographic changes, it is anticipated that the incidence will further increase. Prevention of actinic keratoses is thus of great importance. Read More

    [Actinic keratosis: New concept and therapeutic update].
    Aten Primaria 2017 Apr 17. Epub 2017 Apr 17.
    Servicio de Dermatología, Hospital Arnau de Vilanova, Valencia, España.
    Actinic keratosis (AK) is a common reason for consultation in both Primary Care and Specialised Care. It is the third or fourth most common reason for consultation in dermatology, accounting for up to 5-6% of patients attended. It has also been observed that its prevalence has been increasing in the last 10years, compared to other dermatoses. Read More

    Ingenol mebutate in low amounts for the treatment of actinic keratosis in Korean patients.
    Clin Cosmet Investig Dermatol 2017 30;10:93-98. Epub 2017 Mar 30.
    Department of Dermatology, Keimyung University, College of Medicine, Daegu, Republic of Korea.
    Background: Ingenol mebutate (IM), a novel agent for field therapy of actinic keratosis (AK), has a drawback of inducing local skin reactions (LSRs), which may cause discomfort in patients. To reduce the LSRs, we tried the application of IM in low amounts.

    Objective: The purpose of this study was to review Korean patients with AK being treated with IM and evaluate the LSRs and therapeutic outcomes of low amounts of IM. Read More

    Structured Expert Consensus on Actinic Keratosis: Treatment Algorithm Focusing on Daylight PDT.
    J Cutan Med Surg 2017 Apr 1:1203475417702994. Epub 2017 Apr 1.
    18 Department of Dermatology and Allergology, Vest Hospital, Academic Teaching Hospital University of Bochum, Recklinghausen, Germany.
    Background: A practical and up-to-date consensus among experts is paramount to further improve patient care in actinic keratosis (AK).

    Objectives: To develop a structured consensus statement on the diagnosis, classification, and practical management of AK based on up-to-date information.

    Methods: A systematic review of AK clinical guidelines was conducted. Read More

    A Proposed Scoring System for Assessing the Severity of Actinic Keratosis on the Head: Actinic Keratosis Area and Severity Index (AKASI).
    J Eur Acad Dermatol Venereol 2017 Apr 12. Epub 2017 Apr 12.
    Department of Dermatology, Monklands Hospital, Lanarkshire, University of Glasgow, UK.
    Background: Actinic keratosis (AK) severity is currently evaluated by subjective assessment of patients.

    Objective: To develop and perform an initial pilot validation of a new easy-to-use quantitative tool for assessing AK severity on the head.

    Methods: The actinic keratosis area and severity index (AKASI) for the head was developed based on a review of other severity scoring systems in dermatology, in particular the psoriasis area and severity index (PASI). Read More

    Disseminated superficial actinic porokeratosis treated with ingenol mebutate gel 0.05.
    Cutis 2017 Mar;99(3):E36-E39
    Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
    Disseminated superficial actinic porokeratosis (DSAP) is a chronic condition characterized by numerous atrophic papules and patches with a distinctive peripheral keratotic ridge, typically found on sun-exposed areas. Treatment of DSAP is warranted not only for cosmetic and symptomatic benefits but also to prevent malignant transformation. Successful treatment of DSAP often is difficult and frequently requires the use of multiple modalities. Read More

    Randomized, Controlled Trial of Fractional Carbon Dioxide Laser Resurfacing Followed by Ultrashort Incubation Aminolevulinic Acid Blue Light Photodynamic Therapy for Actinic Keratosis.
    Dermatol Surg 2017 Apr 6. Epub 2017 Apr 6.
    *Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut; †Dermatology and Laser Surgery Center, New York, New York.
    Background: Aminolevulinic acid (ALA) photodynamic therapy (PDT) is an established treatment option for actinic keratosis (AK), and recently fractional carbon dioxide (CO2) laser was shown to improve outcomes; but studies of short incubation photosensitizer are lacking.

    Objective: Assess the efficacy of short incubation ALA followed by blue light PDT with and without previous fractional CO2 treatment for the treatment of AK.

    Methods: Randomized, paired split-design, controlled trial of fractional CO2 followed by ultrashort 15-minute versus 30-minute incubation ALA and blue light PDT for the treatment of AK on the face. Read More

    [Skin carcinogenesis in renal transplant recipients].
    Rev Med Liege 2017 Mar;72(3):146-150
    Service de Dermatopathologie, CHU de Liège, Site du Sart Tilman, Liège, Belgique.
    Organ transplants are bound to the induction and upkeep of immunosuppression. The immunomodulatory regimen modalities have changed over time with an improvement of the overage graft survival. The effects are also present on the skin and its cancerogenesis which is particularly activated for the squamous cell carcinoma. Read More

    Photodynamic Therapy Effective for the Treatment of Actinic Keratosis and Basal Cell Carcinoma in Bullous Pemphigoid Patients.
    Photodiagnosis Photodyn Ther 2017 Mar 31. Epub 2017 Mar 31.
    Department of Dermatology, University of Alabama at Birmingham, United States. Electronic address:
    Treating skin cancers and extensive actinic keratosis in patients with bullous pemphigoid (BP) can be challenging. Treatment options pose unique risks in these patients as surgical wounds can have delayed wound healing and photodynamic therapy (PDT) may exacerbate their blistering disease. We report the successful use of PDT to treat actinic keratosis and skin cancers in two patients with BP, both of whom had excellent response to PDT and tolerated treatment without any bullous disease flares. Read More

    Analysis of Apoptosis-associated Molecules Erythroid Differentiation Regulator 1, bcl-2, and p53 in Actinic Keratosis after Treatment with Ingenol Mebutate.
    Exp Dermatol 2017 Mar 31. Epub 2017 Mar 31.
    Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea.
    AK is the most common cutaneous premalignant neoplasm precursor of malignant skin tumors. The aberrant apoptotic pathway is thought to be associated with pathogenesis of AK. Ingenol mebutate has been shown to be effective and safe for treatment of AK. Read More

    Red light photodynamic therapy for actinic keratosis using 37 J/cm(2) : Fractionated irradiation with 12.3 mW/cm(2) after 30 minutes incubation time compared to standard continuous irradiation with 75 mW/cm(2) after 3 hours incubation time using a mathematical modeling.
    Lasers Surg Med 2017 Apr 2. Epub 2017 Apr 2.
    Univ. Lille, INSERM, CHU Lille, U1189-ONCO-THAI-Image Assisted Laser Therapy for Oncology, F-59000 Lille, France.
    Objective And Study Design: Photodynamic therapy (PDT) is an emerging treatment modality for various diseases, especially for dermatological conditions. Although, the standard PDT protocol for the treatment of actinic keratoses in Europe has shown to be effective, treatment-associated pain is often observed in patients. Different modifications to this protocol attempted to decrease pain have been investigated. Read More

    Efficacy of ultra short sub-30 minute incubation of 5-aminolevulinic acid photodynamic therapy in vitro.
    Lasers Surg Med 2017 Mar 29. Epub 2017 Mar 29.
    Dermatology Service, Sacramento VA Medical Center, Mather, California.
    Background And Objective: The estimated incidence of cutaneous squamous cell carcinoma (SCC) is 700,000 cases per year. In the US, SCC incidence is highest among fair skinned adults older than 50 years of age. Thus, as the population ages, the reported number of SCCs will likely increase in the future. Read More

    United States Food and Drug Administration Product Label Changes.
    J Clin Aesthet Dermatol 2017 Feb 1;10(2):20-29. Epub 2017 Feb 1.
    The Icahn School of Medicine at Mount Sinai, Department of Dermatology, New York, New York.
    Once a drug has been approved by the United States Food and Drug Administration and is on the market, the Food and Drug Administration communicates new safety information through product label changes. Most of these label changes occur after a spontaneous report to either the drug manufacturing companies or the Food and Drug Administration MedWatch program. As a result, 400 to 500 label changes occur every year. Read More

    Cellulitis Secondary to Liquid Nitrogen Cryotherapy: Case Report and Literature Review.
    J Cutan Med Surg 2017 Mar 1:1203475417702152. Epub 2017 Mar 1.
    2 Division of Dermatology, Department of Medicine, Queen's University, Kingston, ON, Canada.
    Background: Liquid nitrogen cryotherapy is a commonly used technique to treat a wide variety of dermatologic conditions including actinic keratoses, non-melanoma skin cancers, verrucae, and seborrheic keratoses. The risks associated with liquid nitrogen cryotherapy are important to know and discuss with patients prior to treatment.

    Objective: We report a case of cellulitis secondary to liquid nitrogen cryotherapy for actinic keratosis. Read More

    Efficacy of a film-forming medical device containing sunscreen (50+) and piroxicam 0.8% in actinic keratosis and field cancerization: a multicenter, assessor-blinded, 3 month trial.
    Curr Med Res Opin 2017 Apr 20:1-5. Epub 2017 Apr 20.
    g Solo Practice , Milan , Italy.
    Introduction: Sunscreen protection in subjects with actinic keratosis (AK) is highly recommended to prevent clinical evolution of this in situ skin cancer condition. Use of topical anti-cyclooxygenase drugs such as diclofenac and piroxicam reduces the number of lesions and improves the cancerization field. A film-forming medical device in a cream formulation containing organic and inorganic sun-filters (50+ SPF) and piroxicam 0. Read More

    Increased number of mast cells in the dermis in actinic keratosis lesions effectively treated with imiquimod.
    J Dermatol 2017 Mar 24. Epub 2017 Mar 24.
    Department of Dermatology, Nippon Medical School, Tokyo, Japan.
    Actinic keratosis (AK) is a cutaneous cancer in situ which develops as a result of excessive exposure to ultraviolet (UV). Toll-like receptor (TLR)7 agonist imiquimod is a topical immune response modifier and is effective for the treatment of non-melanoma skin cancers. Recently, the diagnostic role of the dermatoscope has been reported in the course of treatment of AK. Read More

    Significant Role of Collagen XVII And Integrin β4 in Migration and Invasion of The Less Aggressive Squamous Cell Carcinoma Cells.
    Sci Rep 2017 Mar 22;7:45057. Epub 2017 Mar 22.
    Department of Dermatology, PEDEGO Research Unit, Oulu Center for Cell-Matrix Research, MRC Oulu, University of Oulu and Oulu University Hospital, Finland.
    Collagen XVII and integrin α6β4 have well-established roles as epithelial adhesion molecules. Their binding partner laminin 332 as well as integrin α6β4 are largely recognized to promote invasion and metastasis in various cancers, and collagen XVII is essential for the survival of colon and lung cancer stem cells. We have studied the expression of laminin γ2, collagen XVII and integrin β4 in tissue microarray samples of squamous cell carcinoma (SCC) and its precursors, actinic keratosis and Bowen's disease. Read More

    Expert Consensus on Cosmetic Outcomes After Treatment of Actinic Keratosis.
    J Drugs Dermatol 2017 Mar;16(3):260-264

    Dermatologists treat actinic keratosis (AK) primarily because these lesions have the potential to progress to invasive squamous cell carcinoma. Patients, on the other hand, generally seek treatment to remove the lesions and achieve an improved appearance of their skin following treatment. In selecting a treatment option for AK, dermatologists should consider post-treatment cosmesis, because cosmetic outcomes differ across AK treatments. Read More

    Regression Analysis of Local Skin Reactions to Predict Clearance of Actinic Keratosis on the Face in Patients Treated With Ingenol Mebutate Gel: Experience from Randomized Controlled Trials.
    J Drugs Dermatol 2017 Feb;16(2):112-114

    Ingenol mebutate gel, a topical field treatment for actinic keratosis (AK), elicits inflammatory application-site reactions in most patients. This analysis explored the relationship between the intensity of local skin reactions (LSRs) and AK clearance, measured by the reduction in AK count from baseline in 218 patients who were treated for AK on the face in the pivotal Phase 3 studies. The analysis modeled the AK count at week 8, adjusted for baseline count, with the composite LSR score at 1 day after the last treatment application for each patient as a predictor to estimate the mean and 90% prediction interval for the percent reduction in AK count. Read More

    Association between Cataract and Keratinocytic Skin Cancers or Melanoma: Speculating on the Common Role of Sun and Ultraviolet Radiation Exposures.
    Ophthalmic Epidemiol 2017 Mar 13:1-5. Epub 2017 Mar 13.
    b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.
    Purpose: Cataract and sun-related skin conditions are proxies to lifetime UV exposure. We examined the association between them using real-world data from an unselected Israeli population.

    Methods: Computerized data was obtained from an Israeli health maintenance organization regarding cases of sun-related skin pathologies and cataract diagnosed between 2006 and 2011 in 686,260 members aged 40 or above. Read More

    Topical ingenol mebutate: a new treatment modality for multiple actinic keratoses and field cancerization.
    Anticancer Agents Med Chem 2017 Feb 13. Epub 2017 Feb 13.
    Department of Dermatovenereology, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia.
    Background: Ingenol mebutate gel is a recent stirring weapon recommended for the treatment of multiple actinic keratoses (AKs) and field cancerization. This review brings a summary of recent data on the treatment of AKs with ingenol mebutate (IM) providing critical commentary with regard to drug's characteristics, drug's safety profile, treatment regimen, treatment outcome, patient compliance, AK recurrence, cost-effectiveness and cost-utility, as well as guidelines for the management of the treatment of AK.

    Method: We undertook a structured search of bibliographic databases for peer-reviewed scientific articles, including review articles, original research articles as well as case report articles based on inclusion/exclusion criteria. Read More

    CD40 Ligand Is Increased in Mast Cells in Psoriasis and Actinic Keratosis but Less So in Epithelial Skin Carcinomas.
    Cancer Invest 2017 Mar 7;35(3):143-151. Epub 2017 Mar 7.
    a Department of Dermatology , Kuopio University Hospital and University of Eastern Finland , Kuopio , Finland.
    The expression of CD40 ligand (CD40L) in mast cells was investigated in biopsies from lesional and non-lesional skin samples of patients with psoriasis, actinic keratosis (AK), basal cell carcinoma, and squamous cell carcinoma using a sequential double-staining technique. The percentage of CD40L(+) mast cells was higher in the lesional than in the non-lesional skin (p < .003). Read More

    Follicular Porokeratosis, a Porokeratosis Variant.
    Am J Dermatopathol 2017 Feb 27. Epub 2017 Feb 27.
    *Department of Dermatopathology, Pathlab Bay of Plenty, Tauranga, New Zealand; †Skin Dermatology Institute, Tauranga, New Zealand; and ‡Department of Pathology and Molecular Medicine, University of Auckland.
    Porokeratosis derives from a process of abnormal keratinization, resulting in clinical and histologic variants. Follicular involvement is infrequently described, with previous suggestions that it may represent a distinct condition. We describe a case of typical disseminated superficial actinic porokeratosis with additional clinically prominent folliculocentric keratosis. Read More

    A dose-finding trial with a novel ingenol derivative (ingenol disoxate: LEO 43204) for field treatment of actinic keratosis on full face or 250 cm(2) on the chest.
    J Dermatolog Treat 2017 Apr 4:1-7. Epub 2017 Apr 4.
    e Department of Dermatology , Icahn School of Medicine at Mount Sinai , New York , NY , USA.
    Purpose: Actinic keratoses (AKs) may progress to squamous cell carcinoma and can occur in cancerized fields as sub-clinical and clinically visible lesions. Ingenol disoxate gel is a topical field therapy for AK. This Phase I/II trial aimed to assess the safety and efficacy of ingenol disoxate on full face or chest in patients with AKs. Read More

    The importance of patient-centred care to overcome barriers in the management of actinic keratosis.
    J Eur Acad Dermatol Venereol 2017 Mar;31 Suppl 2:17-20
    Department of Cutaneous Medicine & Surgery, The Royal London Hospital & QMUL, Bart's Health NHS Trust, Whitechapel, London, UK.
    Visible actinic keratosis (AK) lesions and subclinical (non-visible) sun damage in the field of cancerization are associated with risk of both non-melanoma skin cancer, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), and, more rarely, melanoma. As the incidences of AK and skin cancer are increasing, effective prevention and treatment of AK is essential to minimize disease burden and improve patient quality of life. Currently, AK lesions are often left untreated and field therapies are underused. Read More

    The importance of treating the field in actinic keratosis.
    J Eur Acad Dermatol Venereol 2017 Mar;31 Suppl 2:8-11
    Klinik für Dermatologie, Venerologie und Allergologie, St. Josef-Hospital, Ruhr-Universität Bochum, Bochum, Germany.
    Actinic keratoses (AKs) are intraepithelial atypical proliferations of keratinocytes that develop in skin that has undergone long-term exposure to ultraviolet radiation. Given the ageing population and an increasing prevalence of AK, the socio-economic burden of AK is likely to rise over the coming years. Areas of subclinical (non-visible) sun damage in the periphery of visible AK lesions contain the same genetic changes as those found in the lesions themselves, and are known as areas of field cancerization. Read More

    From actinic keratosis to squamous cell carcinoma: pathophysiology revisited.
    J Eur Acad Dermatol Venereol 2017 Mar;31 Suppl 2:5-7
    Hospital Universitari General de Catalunya-Grupo Quirón Salud, Universitat Autònoma de Barcelona, Barcelona, Spain.
    The precursor of most cutaneous invasive squamous cell carcinomas (iSCCs) is intraepithelial UV-induced damage, known as field cancerization, which can eventually transform into actinic keratosis (AK). Although AK is the most common precursor of iSCC, many AKs will either persist in the same stage or regress, while only a few will progress into iSCC. Nevertheless, because the progression of individual AKs cannot be predicted, it has been proposed that all AKs, regardless of the grade, should be carefully monitored and appropriately treated in clinical practice. Read More

    Treatment considerations in actinic keratosis.
    J Eur Acad Dermatol Venereol 2017 Mar;31 Suppl 2:12-16
    Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA.
    The chronic skin condition actinic keratosis (AK) is characterized by the formation of keratotic lesions of variable thickness that are poorly delimited. AK occurs on areas of the skin that have had long-term exposure to the sun or UV radiation. Although AKs may regress, they usually persist and can progress to squamous cell carcinoma (SCC). Read More

    A Quantitative Study of In Vivo Protoporphyrin IX Fluorescence Build Up During Occlusive Treatment Phases.
    Photodiagnosis Photodyn Ther 2017 Feb 28. Epub 2017 Feb 28.
    Photobiology Unit, Ninewells Hospital and Medical School, UK. Electronic address:
    Background: Topical photodynamic therapy (PDT) is a non-invasive light based therapy used to treat non-melanoma skin cancer (NMSC) and dysplasia. During PDT, the light sensitive molecule protoporphyrin IX (PpIX) is activated, resulting in the production of singlet oxygen, which subsequently leads to cell death. PpIX is metabolised from a topically applied pro-drug and the strong fluorescence signal associated with PpIX can be utilised as an indicator of the amount of PpIX present within the tumour tissue. Read More

    Topics in histopathology of sweat gland and sebaceous neoplasms.
    J Dermatol 2017 Mar;44(3):315-326
    Division of Dermatology and Dermatopathology, Nippon Medical School Musashi Kosugi Hospital, Kawasaki City, Japan.
    This article reviews several topics regarding sweat gland and sebaceous neoplasms. First, the clinicopathological characteristics of poroid neoplasms are summarized. It was recently reported that one-fourth of poroid neoplasms are composite tumors and one-fourth are apocrine type lesions. Read More

    Variation in the Cost of Managing Actinic Keratosis.
    JAMA Dermatol 2017 Apr;153(4):264-269
    Department of Dermatology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania.
    Importance: Actinic keratosis (AK), a skin growth induced by ultraviolet light exposure, requires chronic management because a small proportion can progress into squamous cell skin cancer. Spending for AK management was more than $1 billion in 2004. Investigating geographic variation in AK spending presents an opportunity to decrease waste or recoup excess spending. Read More

    Photodynamic Therapy and Skin Appendage Disorders: A Review.
    Skin Appendage Disord 2017 Jan 8;2(3-4):166-176. Epub 2016 Dec 8.
    Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
    Photodynamic therapy (PDT) is a noninvasive treatment that utilizes light treatment along with application of a photosensitizing agent. In dermatology, PDT is commonly used and approved for the treatment of oncological conditions such as actinic keratosis, Bowen disease and superficial basal cell carcinoma. In the last 2 decades however, PDT has also been used for the treatment of several nonneoplastic dermatological diseases. Read More

    Ingenol Mebutate Topical Gel A Status Report On Clinical Use Beyond Actinic Keratosis.
    J Clin Aesthet Dermatol 2016 Nov;9(11 Suppl 1):S3-S11
    Adjunct Clinical Professor (Dermatology), Touro University Nevada, Henderson, Nevada; Research Director, Del Rosso Dermatology Research Center, Las Vegas, Nevada.
    Ingenol mebutate is available as a topical gel formulation approved for the treatment of actinic keratosis. Two different concentrations are available for treatment of actinic keratoses at specific anatomic sites with the advantages of short durations of therapy and limited "down time" related to visible inflammation as compared to other topical agents. Due to the various modes of action of ingenol mebutate, it has also been used for treatment of disease states other than actinic keratosis. Read More

    Daylight photodynamic therapy vs. Conventional photodynamic therapy as skin cancer preventive treatment in patients with face and scalp cancerization: an intra-individual comparison study.
    J Eur Acad Dermatol Venereol 2017 Feb 21. Epub 2017 Feb 21.
    First Dermatology Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    Background: Individuals with medical history of non-melanoma skin cancers (NMSCs) usually develop multiple and/or recurrent malignant lesions around the site of the primary neoplasm. The latter represents the clinical expression of the 'field cancerization' theory; supporting the presence of multiple malignant clones of dysplastic keratinocytes over the entire epithelium that potentially can progress into clinical lesions. Taking into consideration that the burden of NMSCs on public health and health-care cost is high, adequate control of recurrences and management of field change is challenging. Read More

    A Rare Case of CK20/CK7 Double Negative Merkel Cell Carcinoma.
    Am J Dermatopathol 2017 Mar;39(3):208-211
    *Department of Pathology, University of California Los Angeles, Los Angeles, CA; †Southern California Permanente Medical Group, Department of Dermatology, Sunset Medical Center, Los Angeles, CA; and ‡Department of Pathology, Kaiser Southern California Permanente Medical Group, Los Angeles, CA.
    The authors present a case of Merkel cell carcinoma (MCC) with unique immunohistochemical staining characteristics. A 57-year-old woman presented with a firm 0.3 cm tan papule on her left nasal-labial fold that was reportedly increasing in size and bleeding. Read More

    The value of reflectance confocal microscopy in diagnosis of flat pigmented facial lesions: a prospective study.
    J Eur Acad Dermatol Venereol 2017 Feb 18. Epub 2017 Feb 18.
    Department of General Dermatology, Medical University of Vienna, Vienna General Hospital (AKH), Vienna, Austria.
    Background: Flat pigmented facial lesions are difficult to diagnose even with dermatoscopy. It is controversial how additional information obtained by in vivo reflectance confocal microscopy (RCM) impacts the diagnosis and management.

    Objective: To examine what in vivo reflectance confocal microscopy of flat pigmented facial lesions adds to clinical examination using dermatoscopy including digital dermatoscopic monitoring. Read More

    Filaggrin loss-of-function mutations, atopic dermatitis and risk of actinic keratosis: results from two cross-sectional studies.
    J Eur Acad Dermatol Venereol 2017 Feb 18. Epub 2017 Feb 18.
    Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
    Background: Common loss-of-function mutations in filaggrin gene (FLG) represent a strong genetic risk factor for atopic dermatitis (AD). Homozygous mutation carriers typically display ichthyosis vulgaris (IV) and many have concomitant AD. Previously, homozygous, but not heterozygous, filaggrin gene mutations have been associated with squamous cell carcinomas. Read More

    Optical coherence tomography in the diagnosis of actinic keratosis - A systematic review.
    Photodiagnosis Photodyn Ther 2017 Feb 7. Epub 2017 Feb 7.
    Department of Dermatology, Zealand University Hospital, Roskilde, Denmark; Health Sciences Faculty, University of Copenhagen, Denmark.
    Background: Optical coherence tomography (OCT) is a real-time non-invasive imaging tool, introduced in dermatology in the late 1990s. OCT uses near-infrared light impulses to produce images which can be displayed in cross-sectional and en-face mode. The technique has been used to image skin diseases especially non-melanoma skin cancer including actinic keratosis (AK). Read More

    Efficacy of iontophoresis-assisted ablative fractional laser photodynamic therapy with short incubation time for the treatment of actinic keratosis: 12-month follow-up results of a prospective, randomised, comparative trial.
    Photodiagnosis Photodyn Ther 2017 Feb 3. Epub 2017 Feb 3.
    Department of Dermatology, College of Medicine, Dong-A University, Busan, Republic of Korea. Electronic address:
    Background: Iontophoresis is a transdermal drug-delivery technique that enhances the transport of ionic species across membranes and may have significant benefit for the treatment of actinic keratosis (AK) by ablative fractional laser-primed photodynamic therapy (AFL-PDT). The aim of this study were to compare the efficacy, recurrence rate, cosmetic outcome and safety of iontophoresis-assisted AFL-PDT with 2hours of incubation vs. those of conventional AFL-PDT with 2- and 3-hour incubation in patients with facial and scalp AK. Read More

    9th Skin Academy Symposium: Building Bridges in Dermatology Chair's Introduction.
    Dermatol Ther (Heidelb) 2017 Jan 1;7(Suppl 1):1-3. Epub 2017 Feb 1.
    Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    An introduction to the proceedings sharing an overview of presentations given as part of the 9th Skin Academy Symposium, held in Barcelona, Spain, April 9-10, 2016. The Skin Academy is an international and interdisciplinary dermatology initiative created to contribute to the growth in scientific knowledge of those dealing with skin diseases. This year's meeting aimed to 'build bridges' between the latest research and everyday clinical practice, providing dermatologists with important updates on some of the most common skin diseases, as well as current 'hot' topics. Read More

    Cyclooxygenase in Cancer Prevention and Treatments for Actinic Keratosis.
    Dermatol Ther (Heidelb) 2017 Jan 1;7(Suppl 1):21-29. Epub 2017 Feb 1.
    NHS Forth Valley, Stirling, Scotland, UK.
    Non-steroidal anti-inflammatory drugs (NSAIDs) are a chemically diverse class of drugs that target the cyclooxygenase (COX) pathway and have anti-inflammatory, analgesic, and antipyretic properties. Elevated expression of COX-2 has been associated with tumor progression in skin cancer through multiple mechanisms. We present evidence for a chemoprotective effect of NSAIDs and discuss potential mechanisms of action of COX-2 in cancer. Read More

    [Immunohistochemical study of the specific features of expression of matrix metalloproteinases 1, 9 in the photoaged skin, the foci of actinic keratosis and basal cell carcinoma].
    Arkh Patol 2016;78(6):17-22
    I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.
    Matrix metalloproteinases (MMPs) mediate the degradation of all types of collagens and other extracellular matrix components (elastin, proteoglycans, and laminin), their synthesis and accumulation play a key role in the hydrolysis of basement membrane. MMPs are involved in a wide range of proteolytic processes in the presence of different physiological and pathological changes, including inflammation, wound healing, angiogenesis, and carcinogenesis.

    Aim: to study the specific features of MMP-1 and MMP-9 expression in different stages of skin photoaging, in the foci of actinic keratosis and basal cell carcinoma by immunohistochemical examination. Read More

    TRAF1 Is Critical for DMBA/Solar UVR-Induced Skin Carcinogenesis.
    J Invest Dermatol 2017 Jan 25. Epub 2017 Jan 25.
    The Hormel Institute, University of Minnesota, Austin, Minnesota, USA. Electronic address:
    TRAF1 is a member of the TRAF protein family, which regulates the canonical and noncanonical NF-κB signaling cascades. Although aberrant TRAF1 expression in tumors has been reported, the role of TRAF1 remains elusive. Here, we report that TRAF1 is required for solar UV-induced skin carcinogenesis. Read More

    Influence of demographic and clinical characteristics of actinic keratosis patients on illness perceptions and readiness to increase sun protection behaviours: an exploratory study.
    Photodermatol Photoimmunol Photomed 2017 Jan 28. Epub 2017 Jan 28.
    Department of Dermatology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
    Background/purpose: There are no data comprehensively investigating the key beliefs and sun protection behaviours in patients with actinic keratosis (AK). Our aim was to determine and correlate the AK perceptions and readiness to increase sun protection (RISP) behaviours.

    Methods: AK patients' (n = 200) demographics and clinical findings were recorded. Read More

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