3,721 results match your criteria Actinic Keratosis


Ingenol mebutate for mycosis fungoides.

Br J Dermatol 2019 Apr 20. Epub 2019 Apr 20.

Department of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Ingenol mebutate is a macrocyclic diterpene ester, naturally found in the sap of the Australian plant Euphorbia peplus, which proved efficacious for actinic keratosis. In clinical routine, we observed local improvement of MF upon application of ingenol mebutate in MF patients treated for coincidental actinic keratosis within direct proximity of/overlapping with MF skin lesions. Hence, the objective of this study was to assess the effect of topical ingenol mebutate on MF skin lesions. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.18018
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http://dx.doi.org/10.1111/bjd.18018DOI Listing
April 2019
5 Reads

Safety and Efficacy of Aminolevulinic Acid 10% Topical Gel versus Aminolevulinic Acid 20% Topical Solution Followed by Blue-light Photodynamic Therapy for the Treatment of Actinic Keratosis on the Face and Scalp: A Randomized, Double-blind Study.

J Clin Aesthet Dermatol 2019 Mar 1;12(3):32-38. Epub 2019 Mar 1.

Drs. Nestor and Berman and Messrs. Patel and Lawson are with the Center for Clinical and Cosmetic Research in Aventura, Florida.

Photodynamic therapy (PDT) using 10% 5-aminolevulinic acid (ALA) gel (GEL) has been shown to be highly effective for treating actinic keratosis (AK) but has only been studied using red-light activation. The goal of this study was to compare GEL and a 20% ALA solution (SOL) using blue-light activation under typical clinical conditions. This double-blind, split-face study randomized subjects to GEL or SOL application to contiguous 25cm fields containing 4 to 8 AK lesions on either side of the face or scalp (no curettage, 1-hour incubation, no occlusion) followed by blue light exposure (1,000 seconds, 417nm, 10J/cm). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440706PMC

Prevalence, Discontinuation Rate, and Risk Factors for Severe Local Site Reactions with Topical Field Treatment Options for Actinic Keratosis of the Face and Scalp.

Medicina (Kaunas) 2019 Apr 4;55(4). Epub 2019 Apr 4.

Department of Infectiology and Dermatology, Riga Stradiņš University, Riga, LV-1006, Latvia.

Actinic keratoses (AKs) are common lesions on chronically sun damaged skin, which are morphologically characterized by lower third to full thickness atypia of epidermal keratinocytes. These lesions carry a risk of progression towards invasive squamous cell carcinoma (SCC); therefore, treatment of visible lesions and the field in case of field cancerization is recommended. Treatment of AK includes the destruction of atypical keratinocytes that clinically presents with various degrees of erythema, scaling, crusting, erosion, and other visible and subjective symptoms. Read More

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http://dx.doi.org/10.3390/medicina55040092DOI Listing
April 2019
1 Read

5-aminolevulinic acid photodynamic therapy with and without Er:YAG laser for actinic keratosis: changes in immune infiltration.

Photodiagnosis Photodyn Ther 2019 Apr 12. Epub 2019 Apr 12.

Department of Dermatology, Faculty of Medicine University of Debrecen, Hungary.

Introduction: Ultraviolet light induced DNA damage, combined with immunosuppression and inflammation are involved in the pathogenesis of actinic keratosis. Photodynamic therapy not only destroys dysplastic cells via tissue destruction and vascular shutdown, but also induces an acute local inflammatory response and activates both the innate and adaptive immune system. In our current work we aimed to compare immunohistochemistry features of inflammatory infiltrate of actinic keratoses after 5-aminolevulinic acid photodynamic therapy with or without Er:YAG laser resurfacing. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.04.010DOI Listing

A diagnostic challenge: inflamed and pigmented seborrheic keratosis. Clinical, dermoscopic, and histopathological correlation.

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

Baskent University Istanbul Hospital Dermatology Clinic, Istanbul.

Pigmented and irritated types of seborrheic keratosis (SK) can be confused with melanoma, basal cell carcinoma, or pigmented actinic keratosis. Dermoscopic examination may give many clues for the diagnosis of SK, but in equivocal cases the accurate diagnosis can only be made by microscopic features. Herein, we report a striking, isolated pigmented and inflamed SK, located on the waist in an elderly man. Read More

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March 2019
3 Reads

Integrating the concept of field cancerization in the classification and risk assessment of cutaneous squamous cell carcinoma: proposal for a new classification and terminology of keratinocyte skin cancer.

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Dermatology Clinic, Maggiore Hospital, University of Trieste, Trieste, Italy.

The term keratinocyte skin cancer (KC) stands as an umbrella for different stages within the progression of cutaneous squamous cell carcinoma (cSCC). Its earliest form is named actinic keratosis (AK), while for the in-situ form different synonyms, namely intraepidermal carcinoma (IEC), Bowen's Diseases (BD) and cutaneous squamous cell carcinoma in situ [cSCC(Tis)] or intraepithelial squamous cell carcinoma (iSCC) are used. Instead, cSCC is histopathologically classified into well, moderately and poorly differentiated subtypes. Read More

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http://dx.doi.org/10.1111/jdv.15624DOI Listing
April 2019
1 Read

Somatic mutations in kinetochore gene KNSTRN are associated with basal proliferating actinic keratoses and cutaneous squamous cell carcinoma.

J Eur Acad Dermatol Venereol 2019 Apr 11. Epub 2019 Apr 11.

CentroDerm GmbH, Heinz-Fangman-Straße 57, Wuppertal, Germany.

Background: Mutations in kinetochore gene KNSTRN accelerate the development of cutaneous squamous cell carcinoma (SCC) and may correlate with different histological classifications of actinic keratosis (AKs).

Objective: To determine KNSTRN gene mutation frequency in healthy skin (HS), actinically damaged skin (ADS), in AKs with different histomorphological gradings, and invasive SCCs.

Methods: All samples were histologically evaluated. Read More

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http://dx.doi.org/10.1111/jdv.15615DOI Listing
April 2019
2 Reads

Low-irradiance red light compared to conventional red light in photodynamic therapy of actinic keratosis: a way to reduce pain during treatment.

Dermatol Ther 2019 Apr 9:e12913. Epub 2019 Apr 9.

INSERM, Univ. Lille, CHU Lille, U1189-OncoThAI - Image Assisted Laser Therapy for Oncology, Lille, France.

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http://dx.doi.org/10.1111/dth.12913DOI Listing

Basal cell carcinomas treated with 0.5% 5-fluorouracil and 10% salicylic acid topical solution.

Dermatol Ther 2019 Apr 9:e12908. Epub 2019 Apr 9.

Dermatologic Unit, University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.

Basal cell carcinomas are the most common non-melanoma skin cancers. Dermoscopy is an indispensable tool to differentiate superficial basal cell carcinoma from other subtypes and between pigmented and not pigmented ones. Although surgery is considered the gold-standard therapy, new current pharmacological options are available and focus on tumor eradication, increasing cosmetic results and functionality. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dth.12908
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http://dx.doi.org/10.1111/dth.12908DOI Listing
April 2019
5 Reads

Review of Clinical Evidence over 10 Years on Prevention and Treatment of a Film-Forming Medical Device Containing Photolyase in the Management of Field Cancerization in Actinic Keratosis.

Dermatol Ther (Heidelb) 2019 Apr 9. Epub 2019 Apr 9.

Dermatology Unit, Second University of Naples, Nuovo Policlinico (Edificio 9C), Via Pansini 5, 80131, Naples, Italy.

Actinic keratosis (AK) is a common pathology that afflicts sun-exposed areas of the skin. It predominantly affects older and fair-skinned individuals suggesting an accumulative damage attributable to chronic sun exposure. The prevalence of AK has risen in the past decades and is expected to continue to rise. Read More

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http://link.springer.com/10.1007/s13555-019-0294-1
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http://dx.doi.org/10.1007/s13555-019-0294-1DOI Listing
April 2019
3 Reads

Atrophic and Hypertrophic Photoaging: Clinical, Histological, and Molecular Features of Two Distinct Phenotypes of Photoaged Skin.

J Am Acad Dermatol 2019 Apr 4. Epub 2019 Apr 4.

University of Michigan, Department of Dermatology, 1910 Taubman Center, Ann Arbor, MI 48109.

Background: Exposure to the sun causes premature skin aging, known as photoaging. Clinical features of photoaging vary widely among individuals. In one form, skin appears thin with telangiectasia, while in another form, skin appears thickened with coarse wrinkles. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.03.081DOI Listing
April 2019
2 Reads

Treatment of the facial basal cell carcinoma with the use of photodynamic therapy: A case report.

Dent Med Probl 2019 Jan-Mar;56(1):105-110

Department of Oral Surgery, Faculty of Dentistry, Wrocław Medical University, Poland.

Basal cell carcinoma (BCC) is the most common skin cancer. It accounts for approx. 80% of human skin cancers and belongs to the group of non-melanoma skin cancers (NMSC). Read More

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http://dx.doi.org/10.17219/dmp/100507DOI Listing
April 2019
1 Read

Photodynamic therapy: A hot topic in dermato-oncology.

Oncol Lett 2019 May 16;17(5):4085-4093. Epub 2019 Jan 16.

Department of Dermatology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Photodynamic therapy (PDT) is a modern, non-invasive therapeutic method used for the destruction of various cells and tissues. It requires the simultaneous presence of three components: a photosensitizer (PS), a light source and oxygen. Precancerous skin lesions are conditions associated with a high likelihood of malignant transformation to squamous cell carcinoma. Read More

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http://www.spandidos-publications.com/10.3892/ol.2019.9939
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http://dx.doi.org/10.3892/ol.2019.9939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444307PMC
May 2019
3 Reads

Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate.

JCI Insight 2019 Apr 4;4(7). Epub 2019 Apr 4.

Department of Medical Microbiology and Immunology and.

Actinic keratosis (AK) is a precancerous skin lesion that is common in HIV-positive patients. Without effective treatment, AKs can progress to squamous cell carcinoma. Ingenol mebutate, a PKC agonist, is a US Food and Drug Administration-approved (FDA-approved) topical treatment for AKs. Read More

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http://dx.doi.org/10.1172/jci.insight.126027DOI Listing
April 2019
2 Reads

5-fluorouracil-induced erythema and transepidermal water loss associated with complete actinic keratosis resolution.

Dermatol Ther 2019 Apr 3:e12890. Epub 2019 Apr 3.

Department of Medicine, Division of Dermatology, University of Arizona, Tucson, Arizona.

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http://dx.doi.org/10.1111/dth.12890DOI Listing

Radiotherapy in Periocular Cutaneous Malignancies: A Retrospective Study.

Dermatology 2019 Apr 2:1-6. Epub 2019 Apr 2.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland,

Background: Due to the importance of function and cosmetics, periocular skin malignancies represent a therapeutic challenge.

Objective: To evaluate the safety and efficacy of radiotherapy (RT) treating periocular skin tumors.

Methods: Data of patients with periocular tumors treated with grenz or soft X-rays at the University Hospital Zurich, Switzerland, between 2009 and 2014 were reviewed. Read More

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http://dx.doi.org/10.1159/000496539DOI Listing
April 2019
4 Reads

Reflectance confocal microscopy in the diagnosis of pigmented macules of the face: differential diagnosis and margin definition.

Photochem Photobiol Sci 2019 Apr 2. Epub 2019 Apr 2.

Department of Surgical, Medical, Dental & Morphological Sciences with Interest Transplant, Oncological & Regenerative Medicine, Dermatology Unit, University of Modena & Reggio Emilia, Modena, Italy.

In vivo reflectance confocal microscopy (RCM) is a noninvasive high-resolution skin imaging tool that has become an important adjunct to clinical exam, dermoscopy and histopathology assessment, in the diagnosis and management of pigmented macules of the face. The diagnosis of early stage lentigo maligna (LM) and lentigo maligna melanoma (LMM) is challenging and RCM improves the diagnostic accuracy in the differential diagnosis of LM with other macules of the face such as solar lentigo (SL), pigmented actinic keratosis (PAK), seborrheic keratosis (SK) and lichen planus-like keratosis (LPLK). Here we review the state-of-the-art of RCM morphologic descriptors, standardized terminology, and diagnostic algorithms for the RCM assessment of pigmented macules of the face including melanocytic, and nonmelanocytic lesions. Read More

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http://dx.doi.org/10.1039/c8pp00525gDOI Listing
April 2019
2 Reads

From actinic keratosis to squamous cell carcinoma - answers to some open questions.

Authors:
J Welzel

Br J Dermatol 2019 Apr;180(4):699-700

Department of Dermatology, University Hospital Augsburg, Sauerbruchstrasse 6, 86179, Augsburg, Germany.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.17637
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http://dx.doi.org/10.1111/bjd.17637DOI Listing
April 2019
4 Reads

A discrete-choice experiment and actinic keratosis: what is the answer?

Authors:
D de Berker

Br J Dermatol 2019 Apr;180(4):691-692

Bristol Dermatology Centre, Bristol Royal Infirmary, Bristol, BS2 8HW, U.K.

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http://dx.doi.org/10.1111/bjd.17184DOI Listing

Regardless of How Risks Are Framed, Patients Seem Hesitant to Use Topical Steroids for Atopic Dermatitis.

Br J Dermatol 2019 Mar 27. Epub 2019 Mar 27.

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Topical corticosteroids are highly effective in treating atopic dermatitis (AD); however, patients often fear their potential adverse events. This fear may be exacerbated by risk aversion. Risk aversion is the tendency to avoid unknown risks in favor of more certain, but less advantageous outcomes. Read More

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http://dx.doi.org/10.1111/bjd.17929DOI Listing
March 2019
1 Read

Geographic variability of pricing and insurance coverage of topical actinic keratosis therapy - a survey-based study.

J Am Acad Dermatol 2019 Mar 22. Epub 2019 Mar 22.

Department of Dermatology, Tufts Medical Center, Boston, MA; Tufts University School of Medicine, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.03.046DOI Listing

0.5% 5-Fluorouracil/10% Salicylic Acid for the Treatment of Distal Actinic Keratoses Under Daily Practice Conditions

J Drugs Dermatol 2019 Mar;18(3):285-288

Background: Actinic keratosis (AKs) are sun-induced skin lesions that are at risk to progress to invasive squamous cell carcinoma (SCC). Treatments have shown to be effective on face or balding scalp area but limited data support their efficacy on distal extremities. Objective: To describe the efficacy of 0. Read More

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Skin cancer precursor immunotherapy for squamous cell carcinoma prevention.

JCI Insight 2019 Mar 21;4(6). Epub 2019 Mar 21.

Center for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Background: Topical calcipotriol plus 5-fluorouracil (5-FU) combination is an effective immunotherapy against actinic keratosis (AK), which is a precursor to squamous cell carcinoma (SCC). However, the long-term effectiveness of calcipotriol plus 5-FU treatment for SCC prevention is unknown.

Methods: We performed a blinded prospective cohort study on participants of a randomized double-blind clinical trial in which a 4-day course of topical calcipotriol plus 5-FU combination was compared to Vaseline plus 5-FU (control) for AK treatment. Read More

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http://dx.doi.org/10.1172/jci.insight.125476DOI Listing
March 2019
2 Reads

Skin diseases are more common than we think: screening results of an unreferred population at the Munich Oktoberfest.

J Eur Acad Dermatol Venereol 2019 Mar 19. Epub 2019 Mar 19.

Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany.

Background: Skin diseases are ranked as the fourth most common cause of human illness, resulting in an enormous non-fatal burden. Despite this, many affected people do not consult a physician. Accordingly, the actual skin disease burden might be even higher since reported prevalence rates are typically based on secondary data that exclude individuals who do not seek medical care. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15494
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http://dx.doi.org/10.1111/jdv.15494DOI Listing
March 2019
3 Reads

Telomeres and Telomerase in Cutaneous Squamous Cell Carcinoma.

Int J Mol Sci 2019 Mar 16;20(6). Epub 2019 Mar 16.

Department of Dermatology, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, 67100 L'Aquila, Italy.

The role of telomere biology and telomerase activation in skin cancers has been investigated in melanoma and basal cell carcinoma but limited evidence is available for cutaneous squamous cell carcinoma (cSCC). We will review the current knowledge on the role of telomere and telomerase pathway in cSCC pathogenesis. At the somatic level, both long and short telomere lengths have been described in cSCC. Read More

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http://dx.doi.org/10.3390/ijms20061333DOI Listing
March 2019
1 Read

Helical Rim Reconstruction With Chondrocutaneous Hatchet Flap-Z Plasty.

Ann Plast Surg 2019 May;82(5):533-536

Department of Plastic, Reconstructive and Aesthetic Surgery, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Background: Helical rim reconstruction is relatively difficult because of the unique anatomical structure of the ear. The aesthetic and functional characteristics of the ear make such reconstruction even more important. This article presents the newly defined chondrocutaneous hatchet flap-Z plasty (HFZP) method in helical rim defects and evaluates the results. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001774DOI Listing
May 2019
1 Read

Split-face study comparing conventional MAL photodynamic therapy in multiple actinic keratosis with complete time vs. half-time red light LED conventional illumination.

J Eur Acad Dermatol Venereol 2019 Mar 13. Epub 2019 Mar 13.

Dermatology Department, Hospital Ramón y Cajal, Madrid, Spain.

Background: Conventional photodynamic therapy (PDT) with methylaminolevulinic acid (MAL) and daylight PDT have demonstrated similar efficacy in the treatment of actinic keratosis (AK). The reason for the use of daylight is to reduce pain during illumination but daylight has the limitation of the weather conditions. The difference in the doses of red light applied between these two methods suggests that an intermediate dose with red light conventional illumination could be effective in PDT of AK. Read More

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http://dx.doi.org/10.1111/jdv.15566DOI Listing
March 2019
1 Read

Randomized Trial of Four Treatment Approaches for Actinic Keratosis.

N Engl J Med 2019 03;380(10):935-946

From the Departments of Dermatology (M.H.E.J., J.P.H.M.K., N.K., A.H.M.M.A., P.M.S., N.W.J.K.-S., K.M.) and Clinical Epidemiology and Medical Technology Assessment (B.A.B.E.), Maastricht University Medical Center, and the GROW School for Oncology and Developmental Biology (M.H.E.J., J.P.H.M.K., A.H.M.M.A., P.M.S., N.W.J.K.-S., K.M.) and the Department of Epidemiology (P.J.N.), Maastricht University, Maastricht, the Department of Dermatology, Zuyderland Medical Center, Heerlen (J.P.H.M.K., P.J.F.Q.), the Department of Dermatology, Catharina Hospital, Eindhoven (A.H.M.M.A., P.M.S.), and the Department of Dermatology, VieCuri Medical Center, Venlo (H.P.A.P.) - all in the Netherlands.

Background: Actinic keratosis is the most frequent premalignant skin disease in the white population. In current guidelines, no clear recommendations are made about which treatment is preferred.

Methods: We investigated the effectiveness of four frequently used field-directed treatments (for multiple lesions in a continuous area). Read More

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http://dx.doi.org/10.1056/NEJMoa1811850DOI Listing
March 2019
2 Reads

The 308-nm excimer laser treatment does not increase the risk of skin cancer in patients with vitiligo: A population-based retrospective cohort study.

Pigment Cell Melanoma Res 2019 Mar 8. Epub 2019 Mar 8.

Department of Dermatology, Chungnam National University Hospital, Daejeon, Korea.

A 308-nm excimer laser (EL) has been widely used to treat patients with localized vitiligo. However, data are rare on the influence of EL treatment on the risks of skin cancer. To evaluate the skin cancer risks after long-term EL treatment, we performed a nationwide population-based retrospective cohort study using the Korean National Health Insurance Claims Database. Read More

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http://dx.doi.org/10.1111/pcmr.12781DOI Listing
March 2019
3 Reads

Comparative study between conventional camera images and smartphone images for eyelid tumor telediagnosis.

Rev Col Bras Cir 2019 Mar 7;46(1):e2083. Epub 2019 Mar 7.

Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Clínica Oftalmológica, São Paulo, SP, Brasil.

Objective: to compare the accuracy of eyelid tumor diagnosis obtained by evaluating conventional camera images with the ones obtained by evaluating smartphone images.

Methods: from January 2016 to July 2017, 36 patients underwent face-to-face external assessments and biomicroscopic examinations to establish clinical diagnoses. The lesions were photographed using Canon PowerShot SX530 HS Digital Camera (16. Read More

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http://dx.doi.org/10.1590/0100-6991e-20192083DOI Listing
March 2019
1 Read

Common skin bacteria protect their host from oxidative stress through secreted antioxidant RoxP.

Sci Rep 2019 Mar 5;9(1):3596. Epub 2019 Mar 5.

Division of Infection Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Cutibacterium acnes is an abundant skin commensal with several proposed mutualistic functions. A protein with strong antioxidant activity was recently identified from the C. acnes secretome. Read More

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http://dx.doi.org/10.1038/s41598-019-40471-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401081PMC
March 2019
4 Reads

What is the most relevent factor during ALA-PDT? A multi-center, open clinical pain score research about actinic keratosis, acne and condylomatata acuminata.

Photodiagnosis Photodyn Ther 2019 Mar 2. Epub 2019 Mar 2.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University, School of Medicine, Shanghai, China. Electronic address:

Background: To date, it has been reported that the intrinsic factors(lesions location, lesions area, disease types) and extrinsic factors(fluence rate) contribute to the pain during 5-aminolevulinic acid photodynamic therapy (ALA-PDT). But there are few studies on pain during ALA-PDT and lack of sufficient clinical evidence related to the pain intensity.

Objective: To investigate pain intensity and its relative factors during ALA-PDT and to provide clinical implication. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.03.001DOI Listing
March 2019
2 Reads

Efficacy of topical imiquimod 3.75% in the treatment of actinic keratosis of the scalp in immunosuppressed patients: our case series.

J Dermatolog Treat 2019 Mar 5:1-5. Epub 2019 Mar 5.

b Department of Health Science , University of Eastern Piedmont , Novara , Italy.

Background: Actinic keratoses (AK) represent common cutaneous lesions, appearing in 'Field cancerization areas' and potentially evolving toward invasive neoplasm. Immunosuppressed patients frequently develop numerous and aggressive AKs.

Aim: In this observational study, we report our experience with topical Imiquimod 3. Read More

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http://dx.doi.org/10.1080/09546634.2019.1590524DOI Listing

Distribution of high-risk α-genus human papillomavirus genotypes impacts cutaneous neoplasms.

J Eur Acad Dermatol Venereol 2019 Mar 5. Epub 2019 Mar 5.

Department of Dermatology and Allergology, University Hospital of Munich LMU, Munich, Germany.

Background: High-risk α-genus human papillomaviruses (α-HPVs) are linked to cervical and genital carcinomas; however, their correlation with cutaneous squamous cell carcinoma (cuSCC) or premalignant skin lesions remains controversial.

Objective: We evaluated the contribution of high-risk α-HPV to the occurrence of cuSCC, Bowen's disease and actinic keratosis (AK), and the distribution of high-risk α-HPV genotypes in these cutaneous tumours.

Methods: HPV genotypes were determined using a commercial PCR-based microarray on skin tissue samples collected from 76 [38 young (<60 years) and 38 elderly (>60 years)] cuSCC, 34 Bowen's disease, 48 AK patients and 10 young controls. Read More

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http://dx.doi.org/10.1111/jdv.15547DOI Listing
March 2019
4 Reads

Daylight photodynamic therapy for severe facial and scalp actinic keratosis: a prospective non-sponsored single-centre study employing the actinic keratosis area and severity index (AKASI).

Eur J Dermatol 2019 Feb;29(1):67-74

Department of Dermatology, Eberhard Karls University, Liebermeisterstr. 25, D-72076 Tübingen, Germany.

Daylight photodynamic therapy (DL-PDT) is an effective and convenient treatment for multiple actinic keratosis (AKs). There are limited tools to evaluate the outcome of AK treatment. Recently, the actinic keratosis area and severity index (AKASI) has been proposed as a quantitative tool for assessing AK severity. Read More

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http://dx.doi.org/10.1684/ejd.2018.3492DOI Listing
February 2019

Comprehensive analysis of β and γ Human Papillomaviruses in actinic keratosis and apparently healthy skin of elderly patients.

Br J Dermatol 2019 Mar 1. Epub 2019 Mar 1.

Department of Infectious Diseases, EVOR Unit, Istituto Superiore di Sanità, Rome, Italy.

DEAR EDITOR, many findings support the role of β human papillomaviruses (HPVs) in cutaneous squamous cell carcinoma (cSCC) and its precursor Actinic Keratosis (AK), in cooperation with UV radiation [1]. Differently from the mucosal high-risk types, which are required throughout the entire carcinogenic process, β-HPVs appear to play a role only at an early stage of skin carcinogenesis. Indeed, β-HPV DNA is not present in all cancer cells and cutaneous HPV prevalence and/or viral load is higher in AK than in cSCC [2, 3, 4]. Read More

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http://dx.doi.org/10.1111/bjd.17836DOI Listing

Reducing unpleasant side effects of topical 5-Fluorouracil treatment for actinic keratosis: a randomized controlled trial.

J Dermatolog Treat 2019 Mar 1:1-5. Epub 2019 Mar 1.

c Department of Medicine, Division of Dermatology , University of Arizona , Tucson , AZ , USA.

Introduction: 5-Fluorouracil (5-FU) for prophylactic treatment of diffuse actinic keratosis results in an exuberant inflammatory reaction, contributing to patient noncompliance and dissatisfaction.

Design: This 5-week split-faced, double-blind, randomized controlled trial involved 30 subjects with diffuse facial AK who received twice daily 5-FU treatment for 2 weeks. This was followed by pre-randomized twice daily use of one of three topical interventions on one half of the face. Read More

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http://dx.doi.org/10.1080/09546634.2019.1589638DOI Listing
March 2019
1 Read

Monitoring sequential treatment of actinic keratosis using post-processed images: ingenol mebutate and cryosurgery.

Photodermatol Photoimmunol Photomed 2019 Feb 27. Epub 2019 Feb 27.

Dermatology Department, Hospital Ramón y Cajal, Madrid, Spain.

Actinic keratoses (AKs) are atypical proliferations of epithelial skin cells. The risk of progression from AK lesions to SCC is well documented. Ingenol Mebutate (IM), a derivative of the plant Euphorbia Peplus, has been used in AK treatment both for lesion-directed and field treatment. Read More

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http://dx.doi.org/10.1111/phpp.12460DOI Listing
February 2019

Ingenol mebutate-mediated reduction in p53-positive keratinocytes in skin cancerization field directly correlates with clinical response in patients with multiple actinic keratoses.

J Eur Acad Dermatol Venereol 2019 Feb 23. Epub 2019 Feb 23.

Department of Surgery and Translational Medicine, Division of Dermatology, University of Florence School of Human Health Sciences, Florence, Italy.

Background: UV radiation represents the main risk factor for non-melanoma skin cancers. Chronic UV exposure induces 'p53 patches', i.e. Read More

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http://doi.wiley.com/10.1111/jdv.15528
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http://dx.doi.org/10.1111/jdv.15528DOI Listing
February 2019
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Insight into the management of actinic keratosis: a qualitative interview study among general practitioners and dermatologists.

Br J Dermatol 2019 Feb 22. Epub 2019 Feb 22.

Department of Dermatology, Erasmus University Medical Centre, 3000 CA, Rotterdam, the Netherlands.

Background: The increasing incidence of actinic keratosis (AK) is causing a large burden on healthcare systems. The current management of patients with AK seems to vary within and between primary and secondary care; however, an in-depth understanding of healthcare providers' management of AK is currently lacking.

Objectives: To gain insight into the management of AK by exploring the underlying motives of current practices among general practitioners (GPs) and dermatologists in the Netherlands. Read More

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http://dx.doi.org/10.1111/bjd.17818DOI Listing
February 2019
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Clinical purpura and elastosis and their correlation with skin tears in an aged population.

Arch Dermatol Res 2019 Apr 20;311(3):231-247. Epub 2019 Feb 20.

School of Public Health, Curtin University, Kent St, Bentley, WA, 6102, Australia.

The previous research reported the results of a prospect cohort study that used logistic regression analysis to construct a risk prediction model for skin tears in individuals aged over 65 years. The model identified three baseline individual characteristics (male gender, history of STs, and history of falls) and two baseline skin manifestations (purpura and elastosis) that predicted the risk of dorsal forearm skin tears. This paper outlines the relationships between baseline skin manifestations and the risk of skin tears. Read More

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http://link.springer.com/10.1007/s00403-019-01899-9
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http://dx.doi.org/10.1007/s00403-019-01899-9DOI Listing
April 2019
5 Reads

Imiquimod 3.75% for field-directed therapy of actinic keratosis: results of a prospective case-series study in Greece.

Int J Dermatol 2019 Feb 19. Epub 2019 Feb 19.

1st Department of Dermatology-Venereology, National and Kapodistrian University of Athens and State Department of Dermatology-Venereology, Andreas Sygros Hospital, Athens, Greece.

Background: Imiquimod 3.75% is a field-directed treatment for actinic keratosis that can detect and treat clinical and subclinical lesions across an entire sun-exposed field. The detection of subclinical lesions is evidenced by an increase in lesions to the maximum lesion count during treatment (L ). Read More

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http://dx.doi.org/10.1111/ijd.14397DOI Listing
February 2019
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Conceptual, Statistical and Clinical interpretation of results from A Systematic Review and Meta-Analysis of Cryosurgery combined with Topical interventions for Actinic Keratosis.

Br J Dermatol 2019 Feb 14. Epub 2019 Feb 14.

The University of Adelaide, North Terrace Campus, Adelaide, South Australia, 5005, Australia.

Furthermore, when conducting meta-analysis by pooling studies, the studies should be analysing the outcome of the same input effect (for ex. in a meta-analysis regarding efficacy of two treatments A & B, you cannot pool the results of a cohort that received treatment A with one that received treatment B, even though the outcome of both cohorts is measured in terms of Risk Ratio). Heppt et al. Read More

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http://dx.doi.org/10.1111/bjd.17772DOI Listing
February 2019

Late fusion of deep and shallow features to improve discrimination of actinic keratosis from normal skin using clinical photography.

Skin Res Technol 2019 Feb 14. Epub 2019 Feb 14.

Department of Skin and Venereal Diseases, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.

Background: Actinic keratosis (AK) is a common premalignant skin lesion that can potentially progress to squamous cell carcinoma. Appropriate long-term management of AK requires close patient monitoring in addition to therapeutic interventions. Computer-aided diagnostic systems based on clinical photography might evolve in the future into valuable adjuncts to AK patient management. Read More

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http://dx.doi.org/10.1111/srt.12684DOI Listing
February 2019
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Photodynamic therapy for actinic keratosis of the forehead and scalp with the Aktilite CL 128: Is there a cut-off value for PpIX-weighted irradiance for effective treatment?

Photodermatol Photoimmunol Photomed 2019 Feb 14. Epub 2019 Feb 14.

Univ. Lille, INSERM, CHU Lille, U1189 - ONCO-THAI - Image Assisted Laser Therapy for Oncology, Lille, France.

Background/purpose: Photodynamic therapy (PDT) is an established treatment for actinic keratosis (AK). Among the approved protocols in Europe, the most widely used involves irradiation with the Aktilite CL 128 (C-PDT). We aimed to assess the heterogeneity of irradiance over the treatment area when using C-PDT. Read More

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http://dx.doi.org/10.1111/phpp.12457DOI Listing
February 2019
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Bundled payment for actinic keratosis management: Pilot evaluation of developed models.

J Am Acad Dermatol 2019 Mar;80(3):679-684

Department of Dermatology, Penn State Health, Hershey, Pennsylvania.

Background: There is an opportunity to explore alternate payment models in dermatology.

Objective: To pilot 2 bundled payment models for actinic keratosis (AK) management.

Methods: A prospective cohort study was conducted during September 2013-June 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183258
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http://dx.doi.org/10.1016/j.jaad.2018.09.012DOI Listing
March 2019
4 Reads

Iceberg sign as a dermoscopic clue of actinic keratosis neglecta.

J Eur Acad Dermatol Venereol 2019 Feb 11. Epub 2019 Feb 11.

Dermatology Department, Hospital de la Santa Creu i Sant Pau, Carrer de Sant Quintí, 89, 08041, Barcelona, Spain.

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http://doi.wiley.com/10.1111/jdv.15484
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http://dx.doi.org/10.1111/jdv.15484DOI Listing
February 2019
6 Reads

Daylight photodynamic therapy in 25 patients with actinic keratosis and evaluation of efficacy by confocal microscopy.

Photodiagnosis Photodyn Ther 2019 Mar 2;25:414-416. Epub 2019 Feb 2.

Dermatology Department, Centro Hospitalar Vila Nova de Gaia/Espinho EPE, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal.

Background: Daylight photodynamic therapy (PDT) has been reported as having similar efficacy to conventional photodynamic therapy in actinic keratosis treatment.

Methods: 25 patients with actinic keratosis of the scalp and/or face were submitted to a daylight photodynamic therapy session. Adverse reactions were evaluated after one week and efficacy after 3 months. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.001DOI Listing
March 2019
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About "Anti-aging effects of ingenol mebutate for patients with actinic keratosis" and phenol-croton oil peelings.

J Am Acad Dermatol 2019 Feb 1. Epub 2019 Feb 1.

Laboratory of Phytotherapy, Phytotherapy Technology and Chemistry of Natural Products, Department of Pharmaceutical Sciences, State University of Ponta Grossa, Brazil.

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http://dx.doi.org/10.1016/j.jaad.2019.01.065DOI Listing
February 2019
2 Reads