3,506 results match your criteria Actinic Keratosis


Physician-Patient Communication and Patient-Reported Outcomes in the Actinic Keratosis TReatment-Adherence INitiative (AK-TRAIN): A Multicenter, Prospective, Real-Life study of Treatment Satisfaction, Quality of Life and Adherence to topical field-directed therapy for the treatment of Actinic Keratosis in Italy.

J Eur Acad Dermatol Venereol 2018 Jun 19. Epub 2018 Jun 19.

Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.

Background: Patients with multiple actinic keratoses (AK) should be treated with field-directed therapy. Such treatments challenge patients' adherence due out-of-pocket costs, length of treatment and severity of Local Skin Reactions (LSRs). Effective physician-patient communication (PPC) may buffer therapy-related distress thus improving quality of life, treatment satisfaction and adherence. Read More

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A tuneable approach to uniform light distribution for artificial daylight photodynamic therapy.

Photodiagnosis Photodyn Ther 2018 Jun 16. Epub 2018 Jun 16.

(a)Photobiology Unit, NHS Tayside, Ninewells Hospital, Dundee, UK; (b)The Scottish Photodynamic Therapy Centre, Dundee, UK.

Objectives: Implementation of daylight photodynamic therapy (dPDT) is somewhat limited by variable weather conditions. Light sources have been employed to provide artificial dPDT indoors, with low irradiances and longer treatment times. Uniform light distribution across the target area is key to ensuring effective treatment, particularly for large areas. Read More

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Efficacy Endpoints in Clinical Trials in Actinic Keratosis.

Dermatol Ther (Heidelb) 2018 Jun 18. Epub 2018 Jun 18.

Department of Dermatology, University of Miami Miller School of Medicine, Miami, USA.

Introduction: Actinic keratosis is regarded as a chronic disease of the skin and, although fluctuating, is chronically progressive. Approval of new products for the treatment of actinic keratosis requires the use of a standard methodology in clinical trials which emphasize complete clearance of all actinic keratoses in a treatment field in a defined time span and the evaluation of long-term efficacy in terms of recurrence rate among completely cleared patients.

Methods: Analysis of data from six previously published clinical trials in patients with actinic keratosis. Read More

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Validity and Reliability of the Dutch Adaptation of the Actinic Keratosis Quality of Life Questionnaire (AKQoL).

Dermatology 2018 Jun 15:1-6. Epub 2018 Jun 15.

Department of Dermatology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.

Background: The Actinic Keratosis Quality of Life Questionnaire (AKQoL) is a disease-specific instrument to measure the impact of actinic keratosis (AK) on patients' lives.

Objective: To validate and test the psychometric properties of the AKQoL translated into the Dutch language (AKQoL-NL).

Methods: All new patients ≥50 years of age with untreated AK in a university medical center and a general hospital between August 2014 and August 2015 were eligible. Read More

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Are actinic keratoses really squamous cell cancer? How do we know if they would become malignant?

Clin Dermatol 2018 May - Jun;36(3):430-432. Epub 2017 Aug 31.

Institute of Dermatology, Campus Bio-Medico University, Rome, Italy.

Actinic keratosis (AK) is a very common skin disease caused by chronic sun exposure. AKs have historically been characterized as being "precancerous" or "premalignant." It is true that these lesions do not possess metastatic potential, because they are confined to the epidermis, but it is not accurate to deem them "premalignant. Read More

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Herbal sun protection agents: Human studies.

Clin Dermatol 2018 May - Jun;36(3):369-375. Epub 2018 Mar 21.

Department of Dermatology, SUNY Downstate Medical Center, Brooklyn, NY.

Topical sunscreens are the mainstay for protection from ultraviolet (UV) radiation. With skin cancer rates on the rise and great interest in reversing or preventing the effects of photoaging, new molecules with potential to defend against UV damage have received a great deal of attention. Specifically, there is a growing interest in herbal substances that offer protection against the damaging effects of UV rays. Read More

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Topical application of 5-fluorouracil 5 percent cream associated with severe neutropenia: discussion of a case and review of systemic reactions after topical treatment with 5-fluorouracil.

Authors:
Philip R Cohen

Dermatol Online J 2018 Apr 15;24(4). Epub 2018 Apr 15.

Department of Dermatology, University of California San Diego, La Jolla, California.

5-fluorouracil, a fluoropyrimidine antineoplastic drug, is used to topically treat actinic keratoses. Local skin reactions to the medication are common and anticipated. However, severe adverse events from topical 5-fluorouracil are rare and unexpected. Read More

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April 2018
4 Reads

Lentigo Maligna - Not Always a Face and Neck Disease of the Elderly.

Dermatology 2018 Jun 12:1-6. Epub 2018 Jun 12.

Centro de Dermatologia Epidermis, Instituto CUF, Porto, Portugal.

Introduction: Lentigo maligna (LM) is a rare form of in situ melanoma, frequently seen as a large patch in elderly patients. The aim of this study was to assess clinical and dermoscopic features of LM.

Material And Methods: A retrospective study of LM patients presenting to our center between July 2007 and July 2017 was performed. Read More

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Differentiation of Different Nonmelanoma Skin Cancer Types Using OCT.

Skin Pharmacol Physiol 2018 Jun 12;31(5):238-245. Epub 2018 Jun 12.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Background: Early detection of various types of nonmelanoma skin cancer has been a challenge in dermatology. Noninvasive examination procedures such as optical coherence tomography (OCT) play an increasingly important role, besides the established gold standard of histological tissue sample analysis. OCT is a noninvasive, cross-sectional, real-time technique that allows conclusions to be drawn with regard to the presence of pathologies. Read More

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Energy-based devices for actinic keratosis field therapy.

Cutis 2018 May;101(5):355-360

Goldenberg Dermatology, PC, New York, USA.

Cutaneous field cancerization arises due to UV-induced carcinogenesis of a "field" of subclinically transformed skin and actinic keratoses (AKs) with a tendency to progress and recur. Commonly used treatment methods for multiple AKs include imiquimod, fluorouracil, ingenol mebutate, and photodynamic therapy; however, new options in field-directed therapy with superior efficacy, cosmesis, and convenience may appeal to patients. Ablative and nonablative lasers may fulfill these advantages and have been investigated as monotherapies and combination therapies for field cancerization. Read More

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Argon plasma coagulation of actinic keratoses imaged by optical coherence tomography: an in-vivo study indicating a possible lesion-directed treatment.

J Biophotonics 2018 Jun 12:e201800075. Epub 2018 Jun 12.

Department of Dermatology, Surgery Unit, Ruhr-University Bochum, Bochum, Germany.

Actinic keratoses (AKs) can progress into invasive squamous cell carcinoma and thus may become a life threatening disease. Argon plasma coagulation (APC) might complement the therapeutic armamentarium in particular for AK lesions. However, there is no data on APC induced micromorphological changes following the treatment of AKs. Read More

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[Gout or squamous cell cancer of the ear in a 91-year-old man - diagnostic and therapeutic problems: a case report].

Wiad Lek 2018 ;71(1 pt 1):88-92

Zakład Onkologii, Uniwersytet Medyczny w Lublinie, Lublin, Polska.

Gout tophi around auricular area are common in old men. The differential diagnosis of papules or nodules on the ear includes tophaceous gout, rheumatoid nodules, basal or squamous cell cancer, melanoma, verruca vulgaris or actinic keratosis. The presence of the skin cancer, most commonly located on the head and neck, is often related to the long exposure of the skin to sunlight. Read More

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January 2018
4 Reads

Impact of red versus blue light on tolerability and efficacy of PDT: a randomized controlled trial.

J Dtsch Dermatol Ges 2018 Jun;16(6):711-717

Department of Dermatology, University of Heidelberg, Germany.

Various light sources may be used for photodynamic therapy of actinic keratosis since photosensitizing agents are activated by different wavelengths. However, the relative impact of red and blue light irradiation on the efficacy and tolerability of therapy is controversial.

Objective: The aim of this study is to compare the efficacy and tolerability of therapy with red versus blue light sources, as well as the patients' evaluation of cosmetic results, clinical response, painfulness and preferred light source for future photodynamic treatments. Read More

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June 2018
1 Read

Effectiveness and safety of 0.5% colchicine cream versus photodynamic therapy with methyl aminolevulinate in the treatment of actinic keratosis and skin field cancerisation of the forearms: a randomized controlled trial.

Br J Dermatol 2018 Jun 3. Epub 2018 Jun 3.

Department of Dermatology and Radiotherapy, FMB-UNESP, Botucatu, SP, Brazil.

Background: Skin field cancerisation (SFC) is an area with UVR induced genomic alterations. Actinic keratosis (AK) is a sign of its activity.

Objective: Evaluate effectiveness and safety of 0. Read More

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June 2018
2 Reads

Assessment of the Effect of 3% Diclofenac Sodium on Photodamaged Skin by Means of Reflectance Confocal Microscopy.

Acta Derm Venereol 2018 Jun 1. Epub 2018 Jun 1.

Dermatology Department, Ramon y Cajal Hospital. Carretera Colmenar Viejo km 9.100, ES-28034 Madrid, Spain.

Treatment of actinic keratosis with 3% Diclofenac sodium w/w in hyaluronic acid is associated with a concomitant improvement in signs of photodamaged skin. However this effect has not yet been examined in depth. Twenty patients with actinic keratosis and signs of photodamaged skin were studied. Read More

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Treatment of Grade II and III Actinic Keratosis Lesions with a Film-Forming Medical Device Containing Sunscreen/Piroxicam 0.8% and a Retinoic Acid/Glycolic Gel: A Pilot Trial.

Dermatol Ther (Heidelb) 2018 May 31. Epub 2018 May 31.

Dermatology Division, Sassuolo Hospital, Sassuolo, Italy.

Introduction: Lesion and field-targeted treatments of actinic keratosis (AK) are commonly indicated for grade I and II type lesions. Grade III lesions are in general more difficult to treat. A film-forming medical device containing piroxicam 0. Read More

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May 2018
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Reflectance confocal microscopy: a crucial role for actinic keratosis treatment monitoring.

Authors:
G Pellacani C Longo

J Eur Acad Dermatol Venereol 2018 May 30. Epub 2018 May 30.

Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.

The article by Ishioka et al . indicates a very important role for reflectance confocal microscopy (RCM) as a non-invasive method that can be successfully used for monitoring actinic keratosis therapeutic response to 5-fluorouracil, with an efficacy similar to histological examination. Furthermore, the results suggest that 5-fluorouracil may be a satisfactory option for therapeutic control of this condition. Read More

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Different outdoor professions have different risks - a cross-sectional study comparing non-melanoma skin cancer risk among farmers, gardeners and mountain guides.

J Eur Acad Dermatol Venereol 2018 May 27. Epub 2018 May 27.

Bavarian Health and Food Safety Authority, Munich, Germany.

Background: One of the main risk factors for non-melanoma skin cancer (NMSC), the most common cancer worldwide, is solar ultraviolet radiation (UVR). This has led to the recognition of NMSC as occupational disease for outdoor workers in several countries. However, outdoor professions are a very heterogeneous group with diverse daily activities and associated UVR exposure. Read More

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Teledermatology-driven topical therapy of actinic keratosis: a comparative study of clinical effectiveness and compliance.

J Eur Acad Dermatol Venereol 2018 May 24. Epub 2018 May 24.

Dermatology Unit & Teledermatology Network, Hospital Universitario Virgen, Macarena, Sevilla, Spain.

Background: Teledermatology (TD) provides efficient care for skin cancer patients.

Objective: To compare the clinical effectiveness of imiquimod 5% for the treatment of AK with in-person care and through TD.

Methods: Longitudinal prospective controlled study including patients with single AK diagnosed and treated at face-to-face visits (FTF group) or through teledermatology (TD group) with imiquimod 5% cream. Read More

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The challenge of diagnosing seborrheic keratosis by reflectance confocal microscopy.

Skin Res Technol 2018 May 24. Epub 2018 May 24.

Department of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, China.

Background: Seborrheic keratosis (SK) is one of the most common skin tumors seen by dermatologists. It should be differentiated with many diseases, especially skin tumors. Reflectance confocal microscopy (RCM) has been applied for evaluation of SK. Read More

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Diclofenac Sodium 3% in Hyaluronic Acid 2.5% Gel Significantly Diminishes the Actinic Keratosis Area and Severity Index.

Skin Pharmacol Physiol 2018 23;31(4):206-211. Epub 2018 May 23.

CentroDerm Clinic, Wuppertal, Germany.

Background/aims: Actinic keratosis area and severity index (AKASI) is a new assessment tool to quantify the severity of actinic damage on the head. Thus far, it has not been evaluated in monitoring the efficacy of field-directed topical treatments in actinic keratosis (AK) in routine clinical practice. Thus, the aim of this study was to determine treatment outcomes by using AKASI 3 months after the initiation of topical application of diclofenac sodium 3% in hyaluronic acid 2. Read More

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Clinical efficiency of dynamic observation of patients with epidermal dysplasia of the skin.

Wiad Lek 2018 ;71(3 pt 2):635-639

State Scientific Institution "Research And Practical Centre Of Preventive And Clinical Medicine" Of The State Administration, Kyiv, Ukraine, Shupyk National Medical Academy Of Postgraduate Education, Kyiv, Ukraine.

Objective: Introduction: Non-melanoma skin cancer is the most common type of cancer among the population of Ukraine. The aim: The study of clinical efficacy of dynamic observation of patients with epidermal dysplasia of the skin.

Patients And Methods: Materials and methods: To study epidermal dysplasia of the skin there was used identifying information of patients, who were under dynamic observation of dermatologists of the State Scientific Institution "Research and Practical Centre of Preventive and Clinical Medicine" of the State Administration in 2013-2017. Read More

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January 2018

Role of In Vivo Reflectance Confocal Microscopy in the Analysis of Melanocytic Lesions.

Acta Dermatovenerol Croat 2018 Apr;26(1):64-67

Elena-Daniela Serban, MD, Department of Medical Oncology, University of Bologna, 40138 Bologna; Italy.

Worldwide melanoma incidence and mortality are increasing (1). Despite the ongoing research, advanced melanoma is still incurable; therefore, the most appropriate solution seems to be early detection combined with complete surgical excision (2). Since the diagnostic protocol of suspicious lesions includes a complete excision with safety margins (2), the problem of unnecessary scarring is significant. Read More

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April 2018
1 Read

Confocal Microscopy in Skin Cancer.

Curr Dermatol Rep 2018 25;7(2):105-118. Epub 2018 Apr 25.

6Medical Screening Unit, Sheba Medical Center, Ramat Gan 5262000, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose Of Review: Reflectance confocal microscopy (RCM) enables imaging of skin lesions at cellular level resolution at the bedside (in vivo) or in freshly excised tissue (ex vivo). This article provides an overview of strengths and limitations of non-invasive RCM in skin cancer diagnosis.

Recent Findings: RCM features of common melanocytic and non-melanocytic skin neoplasms such as melanoma, actinic keratosis/squamous cell carcinoma, basal cell carcinoma, and nevi have been well defined and show good correlation with dermoscopic and histopathologic findings. Read More

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Photodynamic therapy corrects abnormal cancer-associated gene expression observed in actinic keratosis lesions and induces a remodeling effect in photodamaged skin.

J Dermatol Sci 2018 May 17. Epub 2018 May 17.

GALDERMA R&D, 06902 Sophia Antipolis Cedex, France. Electronic address:

Background: Actinic keratoses (AK) are proliferations of neoplastic keratinocytes in the epidermis resulting from cumulative exposure to ultraviolet radiation (UVR), which are liable to transform into squamous cell carcinoma (SCC). Organ Transplant Recipients (OTR) have an increased risk of developing SCC as a consequence of long-term immunosuppressive therapy. The aim of this study was to determine the molecular signature of AKs from OTR prior to treatment with methyl aminolevulinate-photodynamic therapy (MAL-PDT), and to assess what impact the treatment has on promoting remodeling of the photo-damaged skin. Read More

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[Rapidly growing squamous cell carcinoma after ingenol mebutate treatment].

Ann Dermatol Venereol 2018 May 17. Epub 2018 May 17.

Faculté de médecine, clinique dermatologique, université de Strasbourg, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France.

Introduction: Ingenol mebutate is an actinic keratosis treatment, which has a dual action mechanism. It allows a rapid cellular death and a severe inflammation.

Observation: We report the case of a 75 years old patient with a rapidly growing tumor 5 weeks after application of ingenol mebutate on typical actinic keratosis. Read More

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Hyaluronic acid, an efficient biomacromolecule for treatment of inflammatory skin and joint diseases: A review of recent developments and critical appraisal of preclinical and clinical investigations.

Int J Biol Macromol 2018 May 18;116:572-584. Epub 2018 May 18.

Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alma Campus, Bandar Puncak Alam 42300, Selangor, Malaysia. Electronic address:

Hyaluronic acid (HA) plays multifaceted role in regulating various biological processes and maintaining homeostasis into the body. Numerous researches evidenced the biomedical implications of HA in skin repairmen, cancer prognosis, wound healing, tissue regeneration, anti-inflammatory, immunomodulation. The present review was aimed to summarize and critically appraise the recent developments and efficacy of HA for treatment of inflammatory skin and joint diseases. Read More

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May 2018
4 Reads

A Rare Syndrome Resembling Scleroderma: Huriez Syndrome.

Skin Appendage Disord 2018 Apr 12;4(2):82-85. Epub 2017 Aug 12.

Department of Pathology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.

Huriez syndrome, also referred to as "sclerotylosis," is a rare autosomal dominant genodermatosis characterized by the triad of congenital scleroatrophy of the distal extremities, palmoplantar keratoderma, and hypoplastic nails. The development of aggressive squamous cell carcinoma (SCC) arising in the scleroatrophic area is also a distinctive feature of the syndrome. Early diagnosis is important due to the early onset, mostly in the third to fourth decades of life, and aggressive progress of SCC, which occurs in around 15% of affected individuals. Read More

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April 2018
3 Reads

A prospective, randomized, within-subject study of ALA-PDT for actinic keratoses using different irradiation regimes.

Photodermatol Photoimmunol Photomed 2018 May 12. Epub 2018 May 12.

Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Photodynamic therapy (PDT) can be used to treat large fields of actinic keratoses (AKs) with high clearance rates. A notable downside is the amount of pain that accompany the treatment. This study aimed to optimize the illumination protocol during conventional PDT in order to reduce pain without compromising treatment effectiveness. Read More

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May 2018
2 Reads

Raman biophysical markers in skin cancer diagnosis.

J Biomed Opt 2018 May;23(5):1-10

University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas, Unites States.

Raman spectroscopy (RS) has demonstrated great potential for in vivo cancer screening; however, the biophysical changes that occur for specific diagnoses remain unclear. We recently developed an inverse biophysical skin cancer model to address this issue. Here, we presented the first demonstration of in vivo melanoma and nonmelanoma skin cancer (NMSC) detection based on this model. Read More

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Features of vascular dermatoscopic component in various morphological types of epidermal dysplasia.

Wiad Lek 2018 ;71(2 pt 1):265-268

State Scientific Institution "Scientific and Practical Centre of Preventive and Clinical Medicine" of the State Administration, Kyiv, Ukraine. Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine.

Objective: Introduction: Dermatologists of many foreign countries have been successfully using and developing dermatoscopy as a method of early diagnosis of skin tumors for three decades. It is believed that the vascular dermatoscopiccomponent is a promising criterion for the diagnosis of epidermal dysplasia of the skin and can be used for differential diagnosis. The aim of the work was to study the features of the vascular dermatoscopic component in actinic keratosis (AK), non-invasive (squamous cell carcinoma in situ-SCCis) and invasive forms of squamous cell carcinoma (cSCC). Read More

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January 2018

Photosensitizing Antihypertensive Drug Use and Risk of Cutaneous Squamous Cell Carcinoma.

Br J Dermatol 2018 May 3. Epub 2018 May 3.

Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Background: Many antihypertensive drugs (ADs) are photosensitizing, heightening reactivity of the skin to sunlight. Photosensitizing ADs have been associated with lip cancer, but whether they impact cutaneous squamous cell carcinoma (cSCC) risk is unknown.

Objectives: To examine the association between AD use and cSCC risk among a cohort of non-Hispanic whites with hypertension enrolled in a comprehensive integrated healthcare delivery system in northern California (n=28,357). Read More

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Tretinoin (0.05% cream vs. 5% peel) for photoaging and field cancerization of the forearms: randomized, evaluator-blinded, clinical trial.

J Eur Acad Dermatol Venereol 2018 Apr 28. Epub 2018 Apr 28.

Universidade Federal de São Paulo (UNIFESP) - Campus São Paulo, São Paulo, Brazil.

Background: Topical tretinoin cream is the gold standard treatment for skin ageing, particularly photoaging. The purpose of tretinoin peel was to obtain similar results, but in a shorter time, however, there have been few controlled trials on its effectiveness.

Objective: To compare efficacy and safety of tretinoin 0. Read More

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April 2018
1 Read

[Occupational skin cancer : Prevention and recommendations for UV protection as part of the treatment approved by the public statutory employers' liability insurance].

Hautarzt 2018 Jun;69(6):462-470

Abteilung Dermatologie, Umweltmedizin und Gesundheitstheorie, Universität Osnabrück, Am Finkenhügel 7a, 49076, Osnabrück, Deutschland.

In Germany, approximately 2 to 3 million employees work in outdoor professions. They are exceptionally exposed to solar ultraviolet (UV) radiation for a large part of their daily working time. Cumulative UV exposure is associated with a significantly increased risk of skin cancer for outdoor workers from various occupational groups (e. Read More

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Using Stratum Corneum Thickness and Configuration to Distinguish Lichenoid Dermatoses.

Authors:
Amanda F Marsch

Am J Dermatopathol 2018 Apr 24. Epub 2018 Apr 24.

Department of Dermatology, UCSD, La Jolla, San Diego, CA.

Background: Clues in the stratum corneum (SC) can aide in histopathologic diagnosis of many conditions.

Objective: To determine if SC configuration and thickness could help differentiate the lichenoid dermatoses.

Methods: A retrospective study was performed. Read More

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[Early detection of occupational skin diseases in sewer workers].

Hautarzt 2018 Apr 25. Epub 2018 Apr 25.

Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, Biedersteiner Str. 29, 80802, München, Deutschland.

Background: Skin diseases affect 30-70% of the world population, and globally, skin cancer rates are continuously increasing. In this respect, prevention programs and early detection of skin diseases are of particular importance.

Objectives: To screen sewer workers for skin diseases with regard to their work-related risk. Read More

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Photodynamic therapy with the use of superluminescent diodes (sLED) in the treatment of actinic keratosis.

Photodiagnosis Photodyn Ther 2018 Jun 22;22:187-190. Epub 2018 Apr 22.

Departament of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Poland, Radziwiłłowska 13 St., 20-080 Lublin, Poland.

Background: Superluminescent diodes (sLED) appear to be an innovative and promising light source in photodynamic therapy (PDT), especially in actinic keratosis (AK) lesions treatment.

Aim: Assessment of tolerability and efficacy of sLED in topical 5-aminolevulinic acid (ALA) PDT of AK lesions.

Methods: 27 patients received ALA PDT with the use of sLED with "soft starter". Read More

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June 2018
1 Read

Lentigo maligna: diagnosis and treatment.

G Ital Dermatol Venereol 2018 Apr 19. Epub 2018 Apr 19.

Institute of Dermatology, Catholic University of Rome, Fondazione Policlinico Universitario A. Gemelli, Rome, Italy.

Lentigo maligna (LM) is an in situ subtype of melanoma, clinically presenting as a pigmented, asymmetric macule that originates mostly on the head and neck and spreads slowly. The diagnosis may be challenging both for clinicians and pathologists. Dermatoscopy and reflectance confocal microscopy represent a useful tool in the differentiation of LM from other pigmented lesions, such as pigmented actinic keratosis, solar lentigines, seborrheic keratosis and lichen planus-like keratosis. Read More

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Medical comorbidities in patients with lichen planopilaris, a retrospective case-control study.

Int J Dermatol 2018 Jul 16;57(7):804-809. Epub 2018 Apr 16.

Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.

Background: Lichen planopilaris (LPP) is a rare inflammatory lymphocyte-mediated disease of the scalp considered to have an autoimmune pathogenesis.

Objectives: To identify the prevalence of medical comorbidities in patients with classic LPP (CLPP) and frontal fibrosing alopecia (FFA).

Methods: The medical records of 206 LPP patients and 323 control patients were retrospectively reviewed for existing comorbidities. Read More

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July 2018
1 Read

Correlations between histopathologic and dermoscopic findings in Korean actinic keratosis.

Microsc Res Tech 2018 Apr 20. Epub 2018 Apr 20.

Department of Dermatology, Korea University College of Medicine, Seoul, Korea.

Skin biopsy for AK diagnosis is usually performed on only a limited part of the whole lesion. Therefore, a clinical diagnosis is important. According to a study, there is no significant correlation between histopathological and clinical classification system. Read More

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April 2018
2 Reads

Epigenetically Enhanced PDT Induces Significantly Higher Levels of Multiple Extrinsic Pathway Apoptotic Factors than Standard PDT, Resulting in Greater Extrinsic and Overall Apoptosis of Cutaneous T-cell Lymphoma.

Photochem Photobiol 2018 Apr 20. Epub 2018 Apr 20.

Department of Dermatology, University of Wisconsin, Madison, WI.

Aminolevulinate-based photodynamic therapy (ALA-PDT) selectively eliminates diseased tissues primarily through the induction of intrinsic apoptotic pathway. ALA-PDT is a first-line therapy for actinic keratosis, however, it is less effective for cutaneous T-cell lymphoma (CTCL). We have previously demonstrated that the resistance of CTCL to apoptosis correlates with decreased expression of death receptors such as FAS, and that methotrexate functions as an epigenetic regulator that reestablishes the susceptibility of CTCL to extrinsic pathway apoptosis. Read More

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Swiss (German) Version of the Actinic Keratosis Quality of Life questionnaire.

Dermatology 2018 Apr 18. Epub 2018 Apr 18.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Background: Actinic keratosis (AK) is a sun-induced skin lesion that may progress to invasive squamous cell carcinoma of the skin. Recently, the Actinic Keratosis Quality of Life questionnaire (AKQoL) was designed for patients with AK in Denmark as a specific quality of life instrument for AK patients.

Objective: The objective of this study was to adapt the AKQoL for the German language region of Switzerland and to evaluate its psychometric properties (validity, reliability). Read More

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April 2018
1 Read

Field-change actinic keratosis and immunosuppression: therapeutic options.

Authors:
S H Ibbotson

Br J Dermatol 2018 Apr;178(4):829-830

Photobiology Unit, Ninewells Hospital & Medical School, University of Dundee, Dundee, DD1 9SY, U.K.

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April 2018
1 Read

Comparison of 10 efficient protocols for photodynamic therapy of actinic keratosis: How relevant are effective light dose and local damage in predicting the complete response rate at 3 months?

Lasers Surg Med 2018 Jul 18;50(5):576-589. Epub 2018 Apr 18.

Univ. Lille, INSERM, CHU Lille, U1189-ONCO-THAI-Image Assisted Laser Therapy for Oncology, Lille, F-59000, France.

Background: Topical photodynamic therapy is an established treatment modality for various dermatological conditions, including actinic keratosis. In Europe, the approved protocols for photodynamic therapy of actinic keratosis involve irradiation with either an Aktilite CL 128 lamp or daylight, whereas irradiation with the Blu-U illuminator is approved in the United States. Many other protocols using irradiation by a variety of light sources are also clinically efficient. Read More

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July 2018
4 Reads

Differential proteomic analysis of actinic keratosis, Bowen's disease and cutaneous squamous cell carcinoma by label-free LC-MS/MS.

J Dermatol Sci 2018 Apr 10. Epub 2018 Apr 10.

Centre for Translational Skin Research, The University of Sydney, Westmead, New South Wales, 2145, Australia; Department of Dermatology, Westmead Hospital, Westmead, New South Wales, 2145, Australia. Electronic address:

Background: The boundaries between actinic keratosis (AK), Bowen's disease (BD), and cutaneous squamous cell carcinoma (cSCC) are sometimes not clear. Large-scale proteomic profiling studies of these lesions are also non-existent.

Objective: To evaluate proteomic changes between normal epidermis, AK, BD and cSCC that could support a molecular classification and improve our understanding of disease progression. Read More

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April 2018
2 Reads

Comparison of Blue and White Lamp Light with Sunlight for Daylight-Mediated, 5-ALA Photodynamic Therapy, in vivo.

Photochem Photobiol 2018 Apr 16. Epub 2018 Apr 16.

Thayer School of Engineering, Dartmouth College, Hanover, NH.

Daylight-mediated photodynamic therapy (d-PDT) as a treatment for actinic keratosis (AK) is an increasingly common technique due to a significant reduction in pain, leading to better patient tolerability. While past studies have looked at different light sources and delivery methods, this study strives to provide equivalent PpIX-weighted light doses with the hypothesis that artificial light sources could be equally as effective as natural sunlight if their PpIX-weighted fluences were equalized. Normal mouse skin was used as the model to compare blue LED light, metal halide white light and natural sunlight, with minimal incubation time between topical ALA application and the onset of light delivery. Read More

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Conjunctival Lesions: When Should We Perform Biopsy?

Nepal J Ophthalmol 2017 Jul;9(18):160-169

Introduction: The conjunctiva is a thin and flexible mucus membrane that provides a protective barrier for the eye. Very few histopathologic studies have been conducted on biopsies from conjunctival lesions (CL) in central India.

Objective: To study the spectrum of CL and define those lesions that need attention with regard to need of biopsy in order to prevent grave sequelae and ocular morbidity. Read More

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July 2017
2 Reads

A new dermoscopic algorithm for the differential diagnosis of facial lentigo maligna and pigmented actinic keratosis.

Eur J Dermatol 2018 Apr;28(2):162-168

Institute of Dermatology, Catholic University of Rome, Rome, Italy.

The clinical and dermoscopic diagnosis of facial lentigo maligna (LM) and pigmented actinic keratosis (PAK) remains challenging, particularly at the early disease stages. To identify dermoscopic criteria that might be useful to differentiate LM from PAK, and to elaborate and validate an automated diagnostic algorithm for facial LM/PAK. We performed a retrospective multicentre study to evaluate dermoscopic images of histologically-proven LM and PAK, and assess previously described dermoscopic criteria. Read More

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April 2018
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A Rare Presentation of Actinic Keratosis Affecting the Tarsal Conjunctiva and Review of the Literature.

Case Rep Ophthalmol Med 2018 12;2018:4375354. Epub 2018 Feb 12.

Ophthalmology Department, Great Western Hospital, Swindon, UK.

We report an unusual case of actinic keratosis (AK) of the tarsal conjunctiva in a 63-year-old man. Examination revealed a crusty, leukoplakic lesion prone to bleeding on the tarsal conjunctiva of the right upper eyelid. This was treated by surgical excisional biopsy. Read More

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February 2018
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